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Aliases for NPIPB8 Gene

Aliases for NPIPB8 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B8 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B8 2

External Ids for NPIPB8 Gene

Previous GeneCards Identifiers for NPIPB8 Gene

  • GC16P028649

Summaries for NPIPB8 Gene

GeneCards Summary for NPIPB8 Gene

NPIPB8 (Nuclear Pore Complex Interacting Protein Family Member B8) is a Protein Coding gene. An important paralog of this gene is NPIPB6.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB8 Gene

Genomics for NPIPB8 Gene

Regulatory Elements for NPIPB8 Gene

Enhancers for NPIPB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G029608 0.8 dbSUPER 20.2 +984.7 984681 1.4 CTCF ZNF140 ZNF266 FEZF1 RAD21 ZNF101 ZNF697 ZNF433 ZNF202 ZNF426 NPIPB8 NPIPB9 NPIPB10P FAM57B PIR61517 PIR60561
GH16G029011 1.4 Ensembl ENCODE dbSUPER 11.4 +388.7 388743 4.2 PKNOX1 TCF12 ZNF121 FOS EGR2 SMARCA5 ZBTB11 CEBPB ZNF426 ZNF623 LAT SPNS1 NPIPB9 NPIPB8 CDC37P1 ENSG00000251417 TUFM KIF22 GC16M028992 NPIPB10P
GH16G028490 1.4 ENCODE dbSUPER 10.8 -130.5 -130490 6.9 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 ZNF610 ENSG00000261766 SULT1A2 NPIPB9 RPS15AP33 ENSG00000260796 NPIPB8 ENSG00000251417 CDC37P1 APOBR TUFM
GH16G029026 0.7 dbSUPER 11.4 +402.2 402220 0.7 ZNF140 ZNF426 REST ZNF394 ZBTB8A ZNF623 ZNF781 ZNF518A ZNF101 ZNF697 NPIPB9 NPIPB8 NPIPB10P GC16M028992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPB8 on UCSC Golden Path with GeneCards custom track

Promoters for NPIPB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084918 -1217 1001 GATAD2A ZNF687 RFX1 NR2F1 MAX SIN3A MNT SMARCB1 RARA E2F1

Genomic Location for NPIPB8 Gene

Chromosome:
16
Start:
28,624,517 bp from pter
End:
28,658,725 bp from pter
Size:
34,209 bases
Orientation:
Plus strand

Genomic View for NPIPB8 Gene

Genes around NPIPB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB8 Gene

Proteins for NPIPB8 Gene

  • Protein details for NPIPB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PQR5-NPIB8_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B8
    Protein Accession:
    E9PQR5

    Protein attributes for NPIPB8 Gene

    Size:
    432 amino acids
    Molecular mass:
    49617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB8 Gene

Post-translational modifications for NPIPB8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB8 Gene

Domains & Families for NPIPB8 Gene

Protein Domains for NPIPB8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PQR5

UniProtKB/Swiss-Prot:

NPIB8_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB8: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NPIPB8 Gene

Function for NPIPB8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB8 Gene

Localization for NPIPB8 Gene

Gene Ontology (GO) - Cellular Components for NPIPB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NPIPB8 Gene

Pathways & Interactions for NPIPB8 Gene

SuperPathways for NPIPB8 Gene

No Data Available

Interacting Proteins for NPIPB8 Gene

Gene Ontology (GO) - Biological Process for NPIPB8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB8 Gene

Drugs & Compounds for NPIPB8 Gene

No Compound Related Data Available

Transcripts for NPIPB8 Gene

mRNA/cDNA for NPIPB8 Gene

(8) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB8 Gene

No ASD Table

Relevant External Links for NPIPB8 Gene

GeneLoc Exon Structure for
NPIPB8
ECgene alternative splicing isoforms for
NPIPB8

Expression for NPIPB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB8 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB8 Gene

This gene is overexpressed in Testis (x10.5).

NURSA nuclear receptor signaling pathways regulating expression of NPIPB8 Gene:

NPIPB8
genes like me logo Genes that share expression patterns with NPIPB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB8 Gene

Orthologs for NPIPB8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 91 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
Species where no ortholog for NPIPB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB8 Gene

ENSEMBL:
Gene Tree for NPIPB8 (if available)
TreeFam:
Gene Tree for NPIPB8 (if available)

Paralogs for NPIPB8 Gene

Pseudogenes.org Pseudogenes for NPIPB8 Gene

genes like me logo Genes that share paralogs with NPIPB8: view

Variants for NPIPB8 Gene

Sequence variations from dbSNP and Humsavar for NPIPB8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000022197 -- 28,652,979(+) TCTTG(C/G)CTCAC intron-variant
rs1000115233 -- 28,652,567(+) CGGGG(A/G)AAGAG intron-variant
rs1000290041 -- 28,636,703(+) TTATC(A/G)TGTAA upstream-variant-2KB
rs1000297066 -- 28,640,995(+) GATTG(C/T)ACAGG intron-variant
rs1000567276 -- 28,641,107(+) ACTCT(C/T)CCAAA intron-variant

Variation tolerance for NPIPB8 Gene

Gene Damage Index Score: 9.01; 87.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPIPB8 Gene

Disorders for NPIPB8 Gene

Relevant External Links for NPIPB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPB8

No disorders were found for NPIPB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB8 Gene

Publications for NPIPB8 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64

Products for NPIPB8 Gene

Sources for NPIPB8 Gene

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