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Aliases for NPIPB6 Gene

Aliases for NPIPB6 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B6 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B6 2
  • Nuclear Pore Complex-Interacting Protein Family Member B6 3
  • Nuclear Pore Complex-Interacting Protein B Type 3
  • NPIPB 3

External Ids for NPIPB6 Gene

Summaries for NPIPB6 Gene

GeneCards Summary for NPIPB6 Gene

NPIPB6 (Nuclear Pore Complex Interacting Protein Family Member B6) is a Protein Coding gene. An important paralog of this gene is NPIPB8.

Additional gene information for NPIPB6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB6 Gene

Genomics for NPIPB6 Gene

GeneHancer (GH) Regulatory Elements for NPIPB6 Gene

Promoters and enhancers for NPIPB6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028364 Promoter 0.9 Ensembl 550.8 +0.2 228 1 L3MBTL2 ZIC2 ZNF316 ZNF600 ZBTB26 EMSY ZNF18 MGA ENSG00000271623 LOC105369182 NPIPB6 GC16P028319
GH16I028363 Promoter 0.5 EPDnew 550.8 +1.5 1474 0.1 NPIPB6 ENSG00000271623 LOC105369182 GC16P028347 GC16P028349 PIR44437 GC16P028348 GC16P028346 GC16P028319
GH16I028973 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 -609.8 -609793 2.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 SPNS1 ENSG00000261067 ENSG00000261766 ATXN2L NPIPB12 NFATC2IP ENSG00000260853 CDIPT SULT1A2 ENSG00000247735
GH16I029335 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.8 -970.7 -970718 0.7 ZNF121 GLIS1 IKZF1 DPF2 ZIC2 SPI1 EGR2 PIR48621 NPIPB6 CDC37P1 SNX29P2 ENSG00000198106 ENSG00000278078
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPIPB6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPB6 Gene

Genomic Locations for NPIPB6 Gene
chr16:28,342,512-28,364,929
(GRCh38/hg38)
Size:
22,418 bases
Orientation:
Minus strand
chr16:28,353,838-28,374,829
(GRCh37/hg19)

Genomic View for NPIPB6 Gene

Genes around NPIPB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB6 Gene

Proteins for NPIPB6 Gene

  • Protein details for NPIPB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PJ23-NPIB6_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B6
    Protein Accession:
    E9PJ23

    Protein attributes for NPIPB6 Gene

    Size:
    425 amino acids
    Molecular mass:
    49162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB6 Gene

Post-translational modifications for NPIPB6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB6 Gene

Domains & Families for NPIPB6 Gene

Gene Families for NPIPB6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPIPB6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PJ23

UniProtKB/Swiss-Prot:

NPIB6_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB6: view

No data available for Suggested Antigen Peptide Sequences for NPIPB6 Gene

Function for NPIPB6 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB6 Gene

Localization for NPIPB6 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NPIPB6 Gene

Pathways & Interactions for NPIPB6 Gene

SuperPathways for NPIPB6 Gene

No Data Available

Interacting Proteins for NPIPB6 Gene

Gene Ontology (GO) - Biological Process for NPIPB6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB6 Gene

Drugs & Compounds for NPIPB6 Gene

No Compound Related Data Available

Transcripts for NPIPB6 Gene

mRNA/cDNA for NPIPB6 Gene

(11) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB6 Gene

No ASD Table

Relevant External Links for NPIPB6 Gene

GeneLoc Exon Structure for
NPIPB6
ECgene alternative splicing isoforms for
NPIPB6

Expression for NPIPB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB6 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB6 Gene

This gene is overexpressed in Testis (x15.3).

NURSA nuclear receptor signaling pathways regulating expression of NPIPB6 Gene:

NPIPB6
genes like me logo Genes that share expression patterns with NPIPB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB6 Gene

Orthologs for NPIPB6 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 84 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 81 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
Species where no ortholog for NPIPB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB6 Gene

ENSEMBL:
Gene Tree for NPIPB6 (if available)
TreeFam:
Gene Tree for NPIPB6 (if available)

Paralogs for NPIPB6 Gene

genes like me logo Genes that share paralogs with NPIPB6: view

Variants for NPIPB6 Gene

Sequence variations from dbSNP and Humsavar for NPIPB6 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000154744 -- 28,356,150(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000235342 -- 28,355,464(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000835662 -- 28,347,607(-) A/G 5_prime_UTR_variant, intron_variant
rs1001391507 -- 28,350,216(-) G/T genic_upstream_transcript_variant, intron_variant
rs1001558142 -- 28,347,965(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPB6 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1124733 CNV duplication 24896259
nsv1152924 CNV duplication 26484159
nsv511572 CNV loss 21212237
nsv833180 CNV loss 17160897
nsv978047 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv984298 CNV duplication 23825009
nsv984399 CNV duplication 23825009

Variation tolerance for NPIPB6 Gene

Gene Damage Index Score: 4.04; 60.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPIPB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB6 Gene

Disorders for NPIPB6 Gene

Additional Disease Information for NPIPB6

No disorders were found for NPIPB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB6 Gene

Publications for NPIPB6 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NPIPB6 Gene

Sources for NPIPB6 Gene

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