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Aliases for NPIPB6 Gene

Aliases for NPIPB6 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B6 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B6 2
  • Nuclear Pore Complex-Interacting Protein Family Member B6 3
  • Nuclear Pore Complex-Interacting Protein B Type 3
  • NPIPB 3

External Ids for NPIPB6 Gene

Summaries for NPIPB6 Gene

GeneCards Summary for NPIPB6 Gene

NPIPB6 (Nuclear Pore Complex Interacting Protein Family Member B6) is a Protein Coding gene. An important paralog of this gene is NPIPB8.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB6 Gene

Genomics for NPIPB6 Gene

Regulatory Elements for NPIPB6 Gene

Enhancers for NPIPB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G028292 1.1 ENCODE 10 +72.2 72165 2.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 NPIPB7 SULT1A2 NPIPB6 NPIPB9 EIF3C CDC37P1 ENSG00000246465 GC16P028319
GH16G027796 1.1 ENCODE dbSUPER 9.8 +568.8 568755 0.2 ELF3 ARID4B SIN3A DNMT3B ZSCAN9 RARA CHAMP1 ZNF766 ZNF143 MIXL1 NPIPB9 NPIPB7 NPIPB6 GC16M027762 GC16P027839
GH16G027783 0.9 dbSUPER 9.8 +580.5 580478 1.6 ELF3 ARID4B SIN3A ZSCAN9 DNMT3B ZNF48 CHAMP1 RARA ZNF766 THAP11 NPIPB9 NPIPB7 NPIPB6 GC16M027762 GC16P027839
GH16G029335 1.2 Ensembl ENCODE dbSUPER 5.8 -970.7 -970718 0.7 MTA2 BHLHE40 GATAD2B DPF2 TBX21 ZIC2 ZNF121 GLIS1 IKZF1 RELB NPIPB6 CDC37P1 PIR48621 ENSG00000278078
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPB6 on UCSC Golden Path with GeneCards custom track

Promoters for NPIPB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084883 229 1001 RNF2 L3MBTL2 ZNF394 ZIC2 ZNF316 ZNF600 EMSY ZNF18 MGA

Genomic Location for NPIPB6 Gene

Chromosome:
16
Start:
28,342,512 bp from pter
End:
28,364,929 bp from pter
Size:
22,418 bases
Orientation:
Minus strand

Genomic View for NPIPB6 Gene

Genes around NPIPB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB6 Gene

Proteins for NPIPB6 Gene

  • Protein details for NPIPB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PJ23-NPIB6_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B6
    Protein Accession:
    E9PJ23

    Protein attributes for NPIPB6 Gene

    Size:
    425 amino acids
    Molecular mass:
    49162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB6 Gene

Post-translational modifications for NPIPB6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NPIPB6 Gene

Domains & Families for NPIPB6 Gene

Protein Domains for NPIPB6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PJ23

UniProtKB/Swiss-Prot:

NPIB6_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB6: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NPIPB6 Gene

Function for NPIPB6 Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB6 Gene

Localization for NPIPB6 Gene

Gene Ontology (GO) - Cellular Components for NPIPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NPIPB6 Gene

Pathways & Interactions for NPIPB6 Gene

SuperPathways for NPIPB6 Gene

No Data Available

Interacting Proteins for NPIPB6 Gene

Gene Ontology (GO) - Biological Process for NPIPB6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB6 Gene

Transcripts for NPIPB6 Gene

mRNA/cDNA for NPIPB6 Gene

(11) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB6 Gene

No ASD Table

Relevant External Links for NPIPB6 Gene

GeneLoc Exon Structure for
NPIPB6
ECgene alternative splicing isoforms for
NPIPB6

Expression for NPIPB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB6 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB6 Gene

This gene is overexpressed in Testis (x15.3).

NURSA nuclear receptor signaling pathways regulating expression of NPIPB6 Gene:

NPIPB6
genes like me logo Genes that share expression patterns with NPIPB6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB6 Gene

Orthologs for NPIPB6 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
Species where no ortholog for NPIPB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB6 Gene

ENSEMBL:
Gene Tree for NPIPB6 (if available)
TreeFam:
Gene Tree for NPIPB6 (if available)

Paralogs for NPIPB6 Gene

Variants for NPIPB6 Gene

Sequence variations from dbSNP and Humsavar for NPIPB6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000154744 -- 28,356,150(+) AAAAA(A/T)GTCAT intron-variant
rs1000235342 -- 28,355,464(+) CATAA(C/T)AGTGT intron-variant
rs1000835662 -- 28,347,607(+) CAAAA(A/G)GAGCT intron-variant, utr-variant-5-prime
rs1001391507 -- 28,350,216(+) AAAAT(G/T)ACATG intron-variant
rs1001558142 -- 28,347,965(+) ATTAT(C/G)CGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPIPB6 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1124733 CNV duplication 24896259
nsv1152924 CNV duplication 26484159
nsv511572 CNV loss 21212237
nsv833180 CNV loss 17160897
nsv978047 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv984298 CNV duplication 23825009
nsv984399 CNV duplication 23825009

Variation tolerance for NPIPB6 Gene

Gene Damage Index Score: 4.04; 60.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB6 Gene

Disorders for NPIPB6 Gene

Relevant External Links for NPIPB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPB6

No disorders were found for NPIPB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB6 Gene

Publications for NPIPB6 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NPIPB6 Gene

Sources for NPIPB6 Gene

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