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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPIPB5 Gene

protein-coding   GIFtS: 21
GCID: GC16P022504

Nuclear Pore Complex Interacting Protein Family, Member...

  Search for NPIPB5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Pore Complex Interacting Protein Family, Member B51 2
Nuclear Pore Complex Interacting Protein Family Member2
Nuclear Pore Complex Interacting Protein Related2

External Ids:    HGNC: 372331   Entrez Gene: 1001322472   Ensembl: ENSG000002437167   UniProtKB: A8MRT53   

Export aliases for NPIPB5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPIPB5 Gene: 
NPIPB5 (nuclear pore complex interacting protein family, member B5) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPIPB5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NPIPB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIPB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

NPIPB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPB5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P022504:  view genomic region     (about GC identifiers)

Start:
22,490,442 bp from pter      End:
22,547,842 bp from pter
Size:
57,401 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: K220L_HUMAN, A8MRT5 (See protein sequence)
Recommended Name: Putative NPIP-like protein LOC100132247  
Size: 1133 amino acids; 126459 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Caution: Could be the product of a pseudogene
Secondary accessions: B4DK13

Explore the universe of human proteins at neXtProt for NPIPB5: NX_A8MRT5

Explore proteomics data for NPIPB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MRT5

  • NPIPB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPIPB5 Protein Expression
    REFSEQ proteins: NP_001129337.1  
    ENSEMBL proteins: 
     ENSP00000445388   ENSP00000442912   ENSP00000440137   ENSP00000441303   ENSP00000440316  
     ENSP00000444299   ENSP00000445754   ENSP00000429898   ENSP00000442935   ENSP00000439898  
     ENSP00000430633   ENSP00000441759   ENSP00000431553   ENSP00000428548   ENSP00000449628  
     ENSP00000440703  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane ----

    NPIPB5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009443 NPIP

    Graphical View of Domain Structure for InterPro Entry A8MRT5

    ProtoNet protein and cluster: A8MRT5

    UniProtKB/Swiss-Prot: K220L_HUMAN, A8MRT5
    Similarity: Belongs to the NPIP family


    NPIPB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPIPB5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about NPIPB5 / K220L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for NPIPB5 gene: 
    NM_001135865.1  

    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000415654(uc010bxg.3) ENST00000415833 ENST00000546168 ENST00000543407
    ENST00000356156 ENST00000541154 ENST00000545375 ENST00000536620 ENST00000544308
    ENST00000538509 ENST00000521555(uc021tew.1 uc010bxi.3 uc010bxk.3)
    ENST00000538606 ENST00000542518 ENST00000540704 ENST00000517539 ENST00000541664
    ENST00000528249 ENST00000517347
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPIPB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NPIPB5 Expression
    About this image


    See NPIPB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPIPB5
        SABiosciences Custom PCR Arrays for NPIPB5
    Primer
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NPIPB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for NPIPB5 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC7510041 putative NPIP-like protein LOC613037-like 84.93(n)
    77.67(a)
      751004  XM_001175412.2  XP_001175412.2 


    ENSEMBL Gene Tree for NPIPB5 (if available)
    TreeFam Gene Tree for NPIPB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPIPB5 gene
    61E3.4  NPIPL3  LOC728888  LOC4403532  NPIPA12  ENSG000001980642  NPIPA52  NPIPA22  
    NPIPB92  ENSG000002330242  NPIPB152  NPIPB32  ENSG000002347192  NPIPA32  ENSG000002262322  NPIPA72  
    LOC7301532  NPIPB112  NPIPB82  NPIPB42  NPIPB72  NPIPB62  NPIPA82  

    NPIPB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 SNPs in NPIPB5 are shown (see all 62)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018084821,2
    C--22541272(+) ACCACA/CCACTC 1 -- int10--------
    rs1911538261,2
    --22541431(+) GTGAGA/GTCCTT 1 -- int10--------
    rs1832896631,2
    --22541463(+) GTGGTA/GTGAGG 1 -- int10--------
    rs174008871,2
    F--22543417(+) CGGCGG/AGCAGA 2 /R syn11Minor allele frequency- A:0.13MN 184
    rs2019227671,2
    F--22545104(+) ACCTCC/TCGAGT 2 P L mis11Minor allele frequency- T:0.04EU 257
    rs2002578571,2
    F--22545109(+) CCGAGT/CGTCTG 2 /R /C mis11Minor allele frequency- C:0.04EU 187
    rs2011613161,2
    F--22545112(+) AGTGTC/GTGCTC 2 L V mis11Minor allele frequency- G:0.10EU 201
    rs2018956421,2
    F--22545118(+) TGCTCA/TCTCCC 2 T S mis11Minor allele frequency- T:0.19EU 197
    rs2002487051,2
    F--22545119(+) GCTCAC/ATCCCC 2 /N /T mis11Minor allele frequency- A:0.17EU 200
    rs2014398411,2
    F--22545169(+) AGTGTG/CTGCTC 2 /L /V mis11Minor allele frequency- C:0.15EU 223

    HapMap Linkage Disequilibrium report for NPIPB5 (22490442 - 22547842 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPIPB5: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPIPB5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPIPB5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NPIPB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PubMed id 11948212)1 Eichler E.E.... Rocchi M. (2001)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100132247 HGNC: 37233 Ensembl:ENSG00000243716 euGenes: HUgn100132247 ECgene: NPIPB5
    H-InvDB: NPIPB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPIPB5 gene:
    Search GeneIP for patents involving NPIPB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NPIPB5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NPIPB5
     Browse SwitchGear Promoter luciferase reporter plasmids for NPIPB5
     Search ThermoFisher Antibodies for NPIPB5
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NPIPB5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPIPB5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPIPB5
    Customized:
     lentivirus for stable overexpression of NPIPB5
     lentivirus expression plasmids for stable overexpression of NPIPB5
     adenovirus for overexpression of NPIPB5
     Search LSBio for Antibodies for NPIPB5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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