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NPIPB5 Gene

protein-coding   GIFtS: 21
GCID: GC16P022507

Nuclear Pore Complex Interacting Protein Family, Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Pore Complex Interacting Protein Family, Member B51 2
Nuclear Pore Complex Interacting Protein Family Member2
Nuclear Pore Complex Interacting Protein Related2

External Ids:    HGNC: 372331   Entrez Gene: 1001322472   Ensembl: ENSG000002437167   UniProtKB: A8MRT53   

Export aliases for NPIPB5 gene to outside databases

Previous GC identifer: GC16P022504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPIPB5 Gene:
NPIPB5 (nuclear pore complex interacting protein family, member B5) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NPIPB5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NPIPB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPIPB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

NPIPB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPB5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P022507:  view genomic region     (about GC identifiers)

Start:
22,490,442 bp from pter      End:
22,547,842 bp from pter
Size:
57,401 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NPIB5_HUMAN, A8MRT5 (See protein sequence)
Recommended Name: Nuclear pore complex-interacting protein family member B5  
Size: 1133 amino acids; 126459 Da
Secondary accessions: B4DK13

Explore the universe of human proteins at neXtProt for NPIPB5: NX_A8MRT5

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001129337.1  
    ENSEMBL proteins: 
     ENSP00000445388   ENSP00000442912   ENSP00000440137   ENSP00000441303   ENSP00000440316  
     ENSP00000444299   ENSP00000445754   ENSP00000429898   ENSP00000442935   ENSP00000439898  
     ENSP00000430633   ENSP00000441759   ENSP00000431553   ENSP00000428548   ENSP00000449628  
     ENSP00000440703  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009443 NPIP

    Graphical View of Domain Structure for InterPro Entry A8MRT5

    ProtoNet protein and cluster: A8MRT5

    UniProtKB/Swiss-Prot: NPIB5_HUMAN, A8MRT5
    Similarity: Belongs to the NPIP family


    Find genes that share domains with NPIPB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NPIPB5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPIB5_HUMAN, A8MRT5: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NPIPB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPIPB5
    Interactions:

        Search GeneGlobe Interaction Network for NPIPB5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPIPB5 (NPIB5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPIPB5 gene: 
    NM_001135865.1  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000415654(uc010bxg.3) ENST00000415833 ENST00000546168 ENST00000543407
    ENST00000356156 ENST00000541154 ENST00000545375 ENST00000536620 ENST00000544308
    ENST00000538509 ENST00000521555(uc021tew.1 uc010bxi.3 uc010bxk.3)
    ENST00000538606 ENST00000542518 ENST00000540704 ENST00000517539 ENST00000541664
    ENST00000528249 ENST00000517347
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPIPB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NPIPB5 Expression
    About this image

    NPIPB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for NPIPB5 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC7507871 putative NPIP-like protein LOC613037-like 88.33(n)
    81.62(a)
      750787  XM_003317896.2  XP_003317944.2 


    ENSEMBL Gene Tree for NPIPB5 (if available)
    TreeFam Gene Tree for NPIPB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPIPB5 gene
    NPIPB31 2  NPIPB41 2  NPIPB111 2  LOC4403532  NPIPA12  NPIPA52  NPIPA22  NPIPB92  
    PKD1P12  ENSG000002330242  NPIPB152  NPIPA32  NPIPA72  LOC1019299102  LOC7299782  LOC7301532  
    NPIPB82  NPIPB72  NPIPB62  NPIPA82  
    Selected SIMAP similar genes for NPIPB5 using alignment to 11 protein entries:     NPIB5_HUMAN (see all proteins) (see all similar genes):
    A-575C2.4    LOC101929910    NPIPB11    NPIPB4    NPIPB3    ACSM1
    NPIPA2    NPIPB8    NPIPB6    NPIPA5    ACSM3    ACSM2A
    NPIPA3    ACSM2B    NPIPB9    A-761H5.4    Nbla00537    NPIPA7

    Find genes that share paralogs with NPIPB5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPIPB5 (see all 62)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018084821,2
    C--22541272(+) ACCACA/CCACTC 1 -- int10--------
    rs1911538261,2
    --22541431(+) GTGAGA/GTCCTT 1 -- int10--------
    rs1832896631,2
    --22541463(+) GTGGTA/GTGAGG 1 -- int10--------
    rs174008871,2
    F--22543417(+) CGGCGG/AGCAGA 2 /R syn11Minor allele frequency- A:0.13MN 184
    rs2019227671,2
    F--22545104(+) ACCTCC/TCGAGT 2 P L mis11Minor allele frequency- T:0.04EU 257
    rs2002578571,2
    F--22545109(+) CCGAGT/CGTCTG 2 /R /C mis11Minor allele frequency- C:0.04EU 187
    rs2011613161,2
    F--22545112(+) AGTGTC/GTGCTC 2 L V mis11Minor allele frequency- G:0.10EU 201
    rs2018956421,2
    F--22545118(+) TGCTCA/TCTCCC 2 T S mis11Minor allele frequency- T:0.19EU 197
    rs2002487051,2
    F--22545119(+) GCTCAC/ATCCCC 2 /N /T mis11Minor allele frequency- A:0.17EU 200
    rs2014398411,2
    F--22545169(+) AGTGTG/CTGCTC 2 /L /V mis11Minor allele frequency- C:0.15EU 223

    HapMap Linkage Disequilibrium report for NPIPB5 (22490442 - 22547842 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPIPB5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPIPB5
    DNA2.0 Custom Variant and Variant Library Synthesis for NPIPB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPIPB5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NPIPB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PubMed id 11948212)1 Eichler E.E.... Rocchi M. (J. Hered. 2001)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100132247 HGNC: 37233 Ensembl:ENSG00000243716 euGenes: HUgn100132247 ECgene: NPIPB5
    H-InvDB: NPIPB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPIPB5 gene:
    Search GeneIP for patents involving NPIPB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     genOway: Develop your customized and physiologically relevant rodent model for NPIPB5
      Search antibodies-online for antibodies for NPIPB5
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