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Aliases for NPIPB5 Gene

Aliases for NPIPB5 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B5 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member B5 2

External Ids for NPIPB5 Gene

Previous GeneCards Identifiers for NPIPB5 Gene

  • GC16P022504
  • GC16P022507

Summaries for NPIPB5 Gene

GeneCards Summary for NPIPB5 Gene

NPIPB5 (Nuclear Pore Complex Interacting Protein Family Member B5) is a Protein Coding gene. An important paralog of this gene is NPIPB4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB5 Gene

Genomics for NPIPB5 Gene

Regulatory Elements for NPIPB5 Gene

Enhancers for NPIPB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F021819 1 ENCODE 96.3 -658.9 -658862 1.6 HDGF ZFP64 ZNF493 SIN3A FEZF1 ZNF2 YY1 ZNF121 ZNF302 ZNF143 NPIPB5 ENSG00000260635 SMG1P1 SMG1P4 ENSG00000260905 MFSD13B RRN3P1 ENSG00000260306 EEF2K DCUN1D3
GH16F021501 1.2 ENCODE 72 -976.6 -976592 2.5 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 THUMPD1 NPIPB5 ENSG00000260635 SMG1P1 SMG1P4 MFSD13B RRN3P1 EEF2K ENSG00000260306 DCUN1D3
GH16F022187 1.9 FANTOM5 Ensembl ENCODE 22.2 -286.9 -286917 9.2 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MFSD13B SMG1P1 POLR3E NPIPB5 C16orf52 PDZD9 ENSG00000260635 SMG1P4 UQCRC2 ENSG00000260973
GH16F022006 1.3 FANTOM5 ENCODE 27 -470.9 -470864 2.8 ATF1 PKNOX1 ARID4B SIN3A ZNF48 YY1 ZNF548 SP3 ZHX2 MIER2 SMG1P4 SMG1P1 NPIPB5 ENSG00000260635 ENSG00000260905 EEF2K VWA3A ENSG00000260306 OTOA ENSG00000275445
GH16F021505 1.4 Ensembl ENCODE 21.3 -969.1 -969072 9.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC NPIPB5 THUMPD1 LOC646828 LOC342293 ENSG00000260306 LOC81691 C16orf52 RRN3P1 SMG1P1 PIR36552
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPB5 Gene

Chromosome:
16
Start:
22,479,121 bp from pter
End:
22,536,535 bp from pter
Size:
57,415 bases
Orientation:
Plus strand

Genomic View for NPIPB5 Gene

Genes around NPIPB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB5 Gene

Proteins for NPIPB5 Gene

  • Protein details for NPIPB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MRT5-NPIB5_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B5
    Protein Accession:
    A8MRT5
    Secondary Accessions:
    • B4DK13

    Protein attributes for NPIPB5 Gene

    Size:
    1133 amino acids
    Molecular mass:
    126459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB5 Gene

Post-translational modifications for NPIPB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NPIPB5 Gene

Domains & Families for NPIPB5 Gene

Protein Domains for NPIPB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8MRT5

UniProtKB/Swiss-Prot:

NPIB5_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NPIPB5 Gene

Function for NPIPB5 Gene

Phenotypes for NPIPB5 Gene

GenomeRNAi human phenotypes for NPIPB5:
genes like me logo Genes that share phenotypes with NPIPB5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB5 Gene

Localization for NPIPB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB5 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NPIPB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPB5: view

No data available for Subcellular locations from COMPARTMENTS for NPIPB5 Gene

Pathways & Interactions for NPIPB5 Gene

SuperPathways for NPIPB5 Gene

No Data Available

Interacting Proteins for NPIPB5 Gene

Gene Ontology (GO) - Biological Process for NPIPB5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB5 Gene

Transcripts for NPIPB5 Gene

mRNA/cDNA for NPIPB5 Gene

(1) REFSEQ mRNAs :
(27) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB5 Gene

No ASD Table

Relevant External Links for NPIPB5 Gene

GeneLoc Exon Structure for
NPIPB5
ECgene alternative splicing isoforms for
NPIPB5

Expression for NPIPB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPB5 Gene

NURSA nuclear receptor signaling pathways regulating expression of NPIPB5 Gene:

NPIPB5
genes like me logo Genes that share expression patterns with NPIPB5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NPIPB5 Gene

Orthologs for NPIPB5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750787 34
  • 88.33 (n)
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
Species where no ortholog for NPIPB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB5 Gene

ENSEMBL:
Gene Tree for NPIPB5 (if available)
TreeFam:
Gene Tree for NPIPB5 (if available)

Paralogs for NPIPB5 Gene

genes like me logo Genes that share paralogs with NPIPB5: view

Variants for NPIPB5 Gene

Sequence variations from dbSNP and Humsavar for NPIPB5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1020960 -- 22,535,893(-) CGCTC(A/G)GAAGG intron-variant, reference, synonymous-codon
rs111270574 -- 22,523,079(+) GGTTG(A/C)AGTGA intron-variant
rs111504279 -- 22,520,880(+) AGAGA(C/T)GGGGT intron-variant
rs111522977 -- 22,530,046(+) TTTCG(C/T)CCCTG intron-variant
rs111642101 -- 22,521,300(+) TGGTC(A/C)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPB5 Gene

Variant ID Type Subtype PubMed ID
dgv3n1 OTHER inversion 15895083
dgv47n16 OTHER inversion 17901297
esv25819 CNV gain 19812545
esv2758637 CNV gain+loss 17122850
esv32980 CNV loss 17666407
esv3368991 OTHER inversion 20981092
esv3407717 CNV duplication 20981092
esv998989 OTHER inversion 20482838
nsv1051649 CNV gain+loss 25217958
nsv1052004 CNV gain 25217958
nsv1077770 OTHER inversion 25765185
nsv1077819 CNV duplication 25765185
nsv1140248 OTHER inversion 24896259
nsv1148848 CNV duplication 26484159
nsv1160373 CNV duplication 26073780
nsv428324 CNV gain 18775914
nsv433439 CNV gain 18776910
nsv433440 CNV gain 18776910
nsv469882 CNV loss 16826518
nsv471386 CNV gain 19718026
nsv471691 CNV gain+loss 15918152
nsv499139 OTHER inversion 21111241
nsv7280 OTHER inversion 18451855
nsv820453 CNV duplication 20802225
nsv827593 CNV gain 20364138
nsv833168 CNV gain+loss 17160897
nsv833171 CNV gain+loss 17160897
nsv9405 CNV gain+loss 18304495
nsv9406 CNV gain+loss 18304495
nsv974882 CNV duplication 23825009
nsv977940 CNV duplication 23825009
nsv978043 CNV duplication 23825009
dgv33n68 CNV loss 17160897
dgv2813n100 CNV loss 25217958
dgv1318n106 CNV duplication 24896259
dgv115n111 CNV duplication 26073780
nsv978205 CNV duplication 23825009
nsv978206 CNV duplication 23825009
nsv984396 CNV duplication 23825009

Variation tolerance for NPIPB5 Gene

Gene Damage Index Score: 1.55; 30.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB5 Gene

Disorders for NPIPB5 Gene

Relevant External Links for NPIPB5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPB5

No disorders were found for NPIPB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB5 Gene

Publications for NPIPB5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PMID: 11948212) Eichler E.E. … Rocchi M. (J. Hered. 2001) 3 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for NPIPB5 Gene

Sources for NPIPB5 Gene

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