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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPIPB4 Gene

protein-coding   GIFtS: 20
GCID: GC16M021848          (predicted)

Nuclear Pore Complex Interacting Protein Family, Member...

  Search for NPIPB4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Pore Complex Interacting Protein Family, Member B41 2
61E3.42
Nuclear Pore Complex Interacting Protein-Like2
NPIPL34
Protein 61E3.44
Uncharacterized Protein4

External Ids:    HGNC: 419851   Entrez Gene: 4403452   Ensembl: ENSG000001858647   UniProtKB: F5H6Z54   UniProtKB: A8MSJ34   
UniProtKB: F5GYP34   UniProtKB: F5H6Y64   UniProtKB: F5H5F24   UniProtKB: E5RHP94   UniProtKB: E7EUG24   
UniProtKB: F5H3D44   UniProtKB: C9JG804   UniProtKB: C9JB184   UniProtKB: H3BQU54   UniProtKB: F5H1084   
UniProtKB: F5GWQ44   UniProtKB: F5H3W24   UniProtKB: F5H8A14   UniProtKB: E7EQW14   

Export aliases for NPIPB4 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPIPB4 Gene: 
NPIPB4 (nuclear pore complex interacting protein family, member B4) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPIPB4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NPIPB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIPB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

NPIPB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPB4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021848:  view genomic region     (about GC identifiers)

Start:
21,845,884 bp from pter      End:
21,892,148 bp from pter
Size:
46,265 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: F5H6Z5 (See protein sequence)
Recommended Name: Protein 61E3.4  
Size: 104 amino acids; 11927 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: A8MSJ3 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 848 amino acids; 95926 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5GYP3 (See protein sequence)

Recommended Name: Protein 61E3.4  
Size: 78 amino acids; 8909 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H6Y6 (See protein sequence)

Recommended Name: Protein 61E3.4  
Size: 120 amino acids; 13965 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H5F2 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 27 amino acids; 3120 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: E5RHP9 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 49 amino acids; 5676 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data
Secondary accessions: E7EQ51

UniProtKB/TrEMBL: E7EUG2 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 992 amino acids; 108683 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H3D4 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 420 amino acids; 45823 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9JG80 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 1138 amino acids; 126699 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9JB18 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 163 amino acids; 19078 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H3BQU5 (See protein sequence)

Recommended Name: Protein 61E3.4  
Size: 84 amino acids; 9683 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H108 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 90 amino acids; 10463 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5GWQ4 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 40 amino acids; 4627 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H3W2 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 104 amino acids; 11927 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: F5H8A1 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 29 amino acids; 3347 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: E7EQW1 (See protein sequence)

Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 148 amino acids; 17284 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for NPIPB4 at MOPED 

NPIPB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NPIPB4 Protein Expression

ENSEMBL proteins: 
 ENSP00000442776   ENSP00000339196   ENSP00000429543   ENSP00000439732   ENSP00000429523  
 ENSP00000439720   ENSP00000433301   ENSP00000442065   ENSP00000443445   ENSP00000404439  
 ENSP00000349936   ENSP00000392155   ENSP00000439166  

Human Recombinant Protein Products for NPIPB4: 
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Browse Sino Biological Cell Lysates 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR009443 NPIP

Graphical View of Domain Structure for InterPro Entry F5H6Z5
Graphical View of Domain Structure for InterPro Entry A8MSJ3
Graphical View of Domain Structure for InterPro Entry F5GYP3
Graphical View of Domain Structure for InterPro Entry F5H6Y6
Graphical View of Domain Structure for InterPro Entry F5H5F2
Graphical View of Domain Structure for InterPro Entry E5RHP9
Graphical View of Domain Structure for InterPro Entry E7EUG2
Graphical View of Domain Structure for InterPro Entry F5H3D4
Graphical View of Domain Structure for InterPro Entry C9JG80
Graphical View of Domain Structure for InterPro Entry C9JB18
Graphical View of Domain Structure for InterPro Entry H3BQU5
Graphical View of Domain Structure for InterPro Entry F5H108
Graphical View of Domain Structure for InterPro Entry F5GWQ4
Graphical View of Domain Structure for InterPro Entry F5H3W2
Graphical View of Domain Structure for InterPro Entry F5H8A1
Graphical View of Domain Structure for InterPro Entry E7EQW1

ProtoNet protein and cluster: F5H6Z5


NPIPB4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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miRNA
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Gene Editing
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Clone
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                     Customized lentivirus expression plasmids for stable overexpression of NPIPB4 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPIPB4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPIPB4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPIPB4

Search CenterWatch for drugs/clinical trials and news about NPIPB4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
ENST00000165086 ENST00000545367 ENST00000542133 ENST00000543660 ENST00000541329
ENST00000539318 ENST00000341400 ENST00000518761 ENST00000543654 ENST00000520808
ENST00000542338 ENST00000539191 ENST00000536041 ENST00000529969 ENST00000540103
ENST00000543449 ENST00000541674 ENST00000544693
miRNA
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Inhib. RNA
Products:
     
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Browse OriGene RNAi
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPIPB4
Clone
Products:
     
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for NPIPB4
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Sirion Biotech Customized lentivirus for stable overexpression of NPIPB4 
                     Customized lentivirus expression plasmids for stable overexpression of NPIPB4 
Primer
Products:
    
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPIPB4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIPB4

2 AceView cDNA sequences:

AW849367 AW849175 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


See NPIPB4 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for NPIPB4
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIPB4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPIPB4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB4 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC7510041 putative NPIP-like protein LOC613037-like 84.8(n)
77.49(a)
  751004  XM_001175412.2  XP_001175412.2 


ENSEMBL Gene Tree for NPIPB4 (if available)
TreeFam Gene Tree for NPIPB4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NPIPB4 gene
LOC100132247  NPIPL3  LOC728888  LOC4403532  NPIPA12  ENSG000001980642  NPIPA52  NPIPA22  
NPIPB92  ENSG000002330242  NPIPB152  NPIPB32  ENSG000002347192  NPIPA32  NPIPA72  ENSG000002262322  
NPIPB52  LOC7301532  NPIPB112  NPIPB82  NPIPB72  NPIPB62  NPIPA82  

NPIPB4 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for NPIPB4
PGOHUM00000260907


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/101 SNPs in NPIPB4 are shown (see all 101)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2018857941,2
F--21847702(+) TCATCG/CGCTGA 2 /P /R mis11Minor allele frequency- C:0.00EU 505
rs1998680291,2
F--21847708(+) GCTGAT/GGGTGG 2 /H /P mis11Minor allele frequency- G:0.01EU 497
rs2020111551,2
F--21847857(+) TTGATG/ATTATC 2 /N syn11Minor allele frequency- A:0.09EU 304
rs8402761,2
F--21848602(+) CGGCAC/G/TGTGTC 3 H P R mis11NA 4
rs10639141,2
C,F--21848644(-) AGCTCC/TACCCT 2 P L mis13Minor allele frequency- T:0.50NA 6
rs749836991,2
F--21848670(-) TGTCTG/ACTCAC 2 /L syn12Minor allele frequency- A:0.33NA 6
rs760922341,2
C--21848694(+) TTGAGA/TTTATC 2 K N mis11Minor allele frequency- T:0.00NA 2
rs763480731,2
F--21848703(-) TCAGCG/AGATGA 2 /A syn13Minor allele frequency- A:0.50NA 8
rs786618231,2
C--21848727(+) GTGAGG/CAGACA 2 /L syn11Minor allele frequency- C:0.50NA 2
rs784858841,2
F--21848736(+) CACTCG/AGGAGG 2 /P syn13Minor allele frequency- A:0.50NA 6

HapMap Linkage Disequilibrium report for NPIPB4 (21845884 - 21892148 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NPIPB4: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing NPIPB4
DNA2.0 Custom Variant and Variant Library Synthesis for NPIPB4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NPIPB4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NPIPB4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1 Loftus B.J.... Adams M.D. (1999)
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1 Nagase T....Nomura N. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 440345 HGNC: 41985 AceView: LOC440345.2 Ensembl:ENSG00000185864 euGenes: HUgn440345
ECgene: NPIPB4 H-InvDB: NPIPB4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NPIPB4 gene:
Search GeneIP for patents involving NPIPB4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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