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Aliases for NPIPB3 Gene

Aliases for NPIPB3 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B3 2 3 5
  • Nuclear Pore Complex-Interacting Protein-Like 3 3 4
  • Protein Pps22-1 3 4
  • NPIPL3 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B3 2
  • Nuclear Pore Complex-Interacting Protein Family Member B3 3
  • PI-3-Kinase-Related Kinase SMG-1 Isoform 1 Homolog 3
  • Nuclear Pore Complex Interacting Protein-Like 3 2
  • Nuclear Pore Complex-Interacting Protein B Type 3
  • KIAA0220-Like Protein 3
  • KIAA0220L 3
  • KIAA0220 4
  • NPIPB5 3
  • NPIPB 3
  • NPIP 3

External Ids for NPIPB3 Gene

Previous HGNC Symbols for NPIPB3 Gene

  • NPIPL3

Summaries for NPIPB3 Gene

GeneCards Summary for NPIPB3 Gene

NPIPB3 (Nuclear Pore Complex Interacting Protein Family Member B3) is a Protein Coding gene. An important paralog of this gene is NPIPB5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB3 Gene

Genomics for NPIPB3 Gene

Regulatory Elements for NPIPB3 Gene

Enhancers for NPIPB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F022204 1.2 ENCODE 4.3 -758.1 -758054 3.8 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SMG1P1 ENSG00000260635 SMG1P4 NPIPB5 MFSD13B ENSG00000260306 NPIPB3 EEF2K ENSG00000261113
GH16F021501 1.2 ENCODE 0.2 -54.0 -53963 2.5 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 THUMPD1 NPIPB5 ENSG00000260635 SMG1P1 SMG1P4 MFSD13B RRN3P1 EEF2K ENSG00000260306 DCUN1D3
GH16F021488 0.4 Ensembl 0.2 -40.3 -40334 0.2 PKNOX1 MIR3680-1 NPIPB3
GH16F021485 0.2 Ensembl 0.3 -38.5 -38534 3.0 MIR3680-1 NPIPB3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPB3 Gene

Chromosome:
16
Start:
21,402,134 bp from pter
End:
21,448,567 bp from pter
Size:
46,434 bases
Orientation:
Minus strand

Genomic View for NPIPB3 Gene

Genes around NPIPB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB3 Gene

Proteins for NPIPB3 Gene

  • Protein details for NPIPB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92617-NPIB3_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B3
    Protein Accession:
    Q92617
    Secondary Accessions:
    • O43332
    • Q504Q6
    • Q59F29
    • Q6GMR1
    • Q6P7T2
    • Q6PIE2
    • Q6RH21

    Protein attributes for NPIPB3 Gene

    Size:
    1050 amino acids
    Molecular mass:
    116847 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13210.2; Type=Frameshift; Positions=203; Evidence={ECO:0000305}; Sequence=BAD92869.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NPIPB3 Gene

neXtProt entry for NPIPB3 Gene

Post-translational modifications for NPIPB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPIPB3 Gene

No data available for DME Specific Peptides for NPIPB3 Gene

Domains & Families for NPIPB3 Gene

Protein Domains for NPIPB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPIPB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92617

UniProtKB/Swiss-Prot:

NPIB3_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB3: view

No data available for Gene Families for NPIPB3 Gene

Function for NPIPB3 Gene

Gene Ontology (GO) - Molecular Function for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NPIPB3: view

Phenotypes for NPIPB3 Gene

GenomeRNAi human phenotypes for NPIPB3:
genes like me logo Genes that share phenotypes with NPIPB3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB3 Gene

Localization for NPIPB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPB3: view

Pathways & Interactions for NPIPB3 Gene

SuperPathways for NPIPB3 Gene

No Data Available

Interacting Proteins for NPIPB3 Gene

Gene Ontology (GO) - Biological Process for NPIPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NPIPB3: view

No data available for Pathways by source and SIGNOR curated interactions for NPIPB3 Gene

Transcripts for NPIPB3 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB3 Gene

No ASD Table

Relevant External Links for NPIPB3 Gene

GeneLoc Exon Structure for
NPIPB3
ECgene alternative splicing isoforms for
NPIPB3

Expression for NPIPB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPB3 Gene

Protein differential expression in normal tissues from HIPED for NPIPB3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPIPB3 Gene



Protein tissue co-expression partners for NPIPB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPIPB3 Gene:

NPIPB3
genes like me logo Genes that share expression patterns with NPIPB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NPIPB3 Gene

Orthologs for NPIPB3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC750787 34
  • 89.91 (n)
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for NPIPB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB3 Gene

ENSEMBL:
Gene Tree for NPIPB3 (if available)
TreeFam:
Gene Tree for NPIPB3 (if available)

Paralogs for NPIPB3 Gene

genes like me logo Genes that share paralogs with NPIPB3: view

Variants for NPIPB3 Gene

Sequence variations from dbSNP and Humsavar for NPIPB3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1061048 -- 21,425,151(-) TTTTT(A/T)AAATT intron-variant
rs112190881 -- 21,401,987(+) GCCTG(C/G)ATGAC downstream-variant-500B
rs112400165 -- 21,403,861(+) CAGGT(A/G)TCTTG reference, missense
rs112910249 -- 21,404,501(+) GGAAG(A/G)GGAGT reference, synonymous-codon
rs113440166 -- 21,404,502(+) GAAGG(A/G)GAGTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NPIPB3 Gene

Variant ID Type Subtype PubMed ID
nsv984394 CNV duplication 23825009
nsv984393 CNV duplication 23825009
nsv984291 CNV duplication 23825009
nsv978204 CNV duplication 23825009
nsv978107 CNV duplication 23825009
nsv9395 CNV gain 18304495
nsv9394 CNV gain 18304495
nsv827584 CNV gain 20364138
nsv436835 CNV insertion 17901297
nsv433438 CNV gain 18776910
nsv433437 CNV gain 18776910
nsv1160372 CNV duplication 26073780
nsv1150881 CNV duplication 26484159
nsv1139646 CNV duplication 24896259
nsv1110272 CNV duplication 24896259
esv3638167 CNV loss 21293372
esv34235 CNV gain 17911159
esv3382085 CNV duplication 20981092
esv3325121 CNV duplication 20981092
esv2758636 CNV gain+loss 17122850
esv25717 CNV gain+loss 19812545
dgv2801n100 CNV loss 25217958
dgv2800n100 CNV gain 25217958

Variation tolerance for NPIPB3 Gene

Gene Damage Index Score: 0.06; 1.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPB3 Gene

Disorders for NPIPB3 Gene

Relevant External Links for NPIPB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPB3

No disorders were found for NPIPB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB3 Gene

Publications for NPIPB3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  3. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PMID: 11948212) Eichler E.E. … Rocchi M. (J. Hered. 2001) 2 3 64
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for NPIPB3 Gene

Sources for NPIPB3 Gene

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