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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPIPB3 Gene

protein-coding   GIFtS: 27
GCID: GC16M021414

Nuclear Pore Complex Interacting Protein Family, Member...

(Previous name: nuclear pore complex interacting protein-like 3)
(Previous symbol: NPIPL3)
  Search for NPIPB3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Pore Complex Interacting Protein Family, Member B31 2     KIAA0220-Like Protein2
NPIPL31 2     Nuclear Pore Complex-Interacting Protein-Like 32
Nuclear Pore Complex Interacting Protein-Like 31 2     PI-3-Kinase-Related Kinase SMG-1 Isoform 1 Homolog2
Protein Pps22-12 3     KIAA02203
KIAA0220L2     

External Ids:    HGNC: 289891   Entrez Gene: 231172   Ensembl: ENSG000001692467   UniProtKB: Q926173   

Export aliases for NPIPB3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NPIPB3 Gene: 
NPIPB3 (nuclear pore complex interacting protein family, member B3) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NPIPB3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NPIPB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIPB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

NPIPB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPB3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M021414:  view genomic region     (about GC identifiers)

Start:
21,413,455 bp from pter      End:
21,459,888 bp from pter
Size:
46,434 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPPL3_HUMAN, Q92617 (See protein sequence)
Recommended Name: Nuclear pore complex-interacting protein-like 3  
Size: 1050 amino acids; 116847 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA13210.2; Type=Frameshift; Positions=203; Sequence=BAD92869.1; Type=Erroneous
initiation;
Secondary accessions: O43332 Q504Q6 Q59F29 Q6GMR1 Q6P7T2 Q6PIE2 Q6RH21
Alternative splicing: 6 isoforms:  Q92617-1   Q92617-2   Q92617-3   Q92617-4   Q92617-5   Q92617-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NPIPB3: NX_Q92617

Explore proteomics data for NPIPB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92617

  • NPIPB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPIPB3 Protein Expression
    REFSEQ proteins: NP_569731.2  
    ENSEMBL proteins: 
     ENSP00000446048   ENSP00000413141   ENSP00000436028   ENSP00000439062   ENSP00000390496  
     ENSP00000399107   ENSP00000444096  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral to membrane IEA--

    NPIPB3 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009443 NPIP

    Graphical View of Domain Structure for InterPro Entry Q92617

    ProtoNet protein and cluster: Q92617

    UniProtKB/Swiss-Prot: NPPL3_HUMAN, Q92617
    Similarity: Belongs to the NPIP family


    NPIPB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    NPIPB3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPIPB3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    NPIPB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPIPB3 (NPPL3)

    Search CenterWatch for drugs/clinical trials and news about NPIPB3 / NPPL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPIPB3 gene: 
    NM_130464.2  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504841 ENST00000419180 ENST00000542953 ENST00000519305 ENST00000521589
    ENST00000534903 ENST00000538439 ENST00000545358 ENST00000535190 ENST00000537983
    ENST00000543368 ENST00000544154 ENST00000448012 ENST00000458643(uc021tem.1 uc002dix.1)
    ENST00000542817
    miRNA
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    24/164 AceView cDNA sequences (see all 164):

    AA564228 CA438242 AI277413 AI270541 BE328636 CA421282 AI399832 AA411774 
    AI075022 BM982433 BU732827 BM968355 AI741575 AW439743 BQ721066 AI470738 
    AA861882 BU688923 AA563993 AI566168 BF993004 CA412409 H01471 AA983637 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPIPB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NPIPB3 Expression
    About this image


    See NPIPB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPIPB3
        SABiosciences Custom PCR Arrays for NPIPB3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPIPB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for NPIPB3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC7510041 putative NPIP-like protein LOC613037-like 80.02(n)
    73.01(a)
      751004  XM_001175412.2  XP_001175412.2 


    ENSEMBL Gene Tree for NPIPB3 (if available)
    TreeFam Gene Tree for NPIPB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPIPB3 gene
    LOC728888  61E3.4  LOC100132247  LOC4403532  NPIPA12  ENSG000001980642  NPIPA52  NPIPA22  
    NPIPB92  ENSG000002330242  NPIPB152  ENSG000002347192  NPIPA32  NPIPA72  ENSG000002262322  NPIPB52  
    LOC7301532  NPIPB112  NPIPB82  NPIPB42  NPIPB72  NPIPB62  NPIPA82  

    NPIPB3 for paralogs           About GeneDecksing


    5/12 Pseudogenes.org Pseudogenes for NPIPB3 (see all 12)
    PGOHUM00000256603 PGOHUM00000259011 PGOHUM00000259013 PGOHUM00000259018 PGOHUM00000259030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/67 SNPs in NPIPB3 are shown (see all 67)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001875171,2
    F--21414377(+) CCGCTG/CAGGGT 1 -- int11Minor allele frequency- C:0.02EU 279
    rs2007110071,2
    F--21414415(+) GGTGTC/ATTGAT 1 -- int11Minor allele frequency- A:0.11EU 141
    rs2017081961,2
    F--21414503(+) CCGCTG/CAGGGT 1 -- int11Minor allele frequency- C:0.02EU 287
    rs1999801821,2
    F--21414541(+) GGTGTC/ATTGAT 1 -- int11Minor allele frequency- A:0.12EU 135
    rs2009174921,2
    F--21414768(+) CCGCTG/CAGGGT 2 /Q /E mis11Minor allele frequency- C:0.06EU 287
    rs2018678171,2
    F--21414806(+) GGTGTC/ATTGAT 2 /R /I mis11Minor allele frequency- A:0.11EU 147
    rs2008797051,2
    F--21414870(+) CGGAAG/AGTGTC 2 /L /F mis11Minor allele frequency- A:0.08EU 277
    rs2019507741,2
    F--21415020(+) CCGCTG/CAGGGT 2 /Q /E mis11Minor allele frequency- C:0.03EU 279
    rs2002704471,2
    F--21415058(+) GGTGTC/ATTGAT 2 /R /I mis11Minor allele frequency- A:0.10EU 145
    rs1998236281,2
    F--21415182(+) CAGGTG/ATCTTG 2 /H /Y mis11Minor allele frequency- A:0.01EU 227

    HapMap Linkage Disequilibrium report for NPIPB3 (21413455 - 21459888 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NPIPB3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPIPB3
    DNA2.0 Custom Variant and Variant Library Synthesis for NPIPB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPIPB3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NPIPB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Divergent origins and concerted expansion of two segmental duplications on chromosome 16. (PubMed id 11948212)1, 3 Eichler E.E.... Rocchi M. (2001)
    4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23117 HGNC: 28989 AceView: LOC23117.1 Ensembl:ENSG00000169246 euGenes: HUgn23117
    ECgene: NPIPB3 H-InvDB: NPIPB3

    (According to HUGE)
    About This Section
    HUGE: KIAA0220-like protein KIAA0220L KIAA0220

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPIPB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPIPB3 gene:
    Search GeneIP for patents involving NPIPB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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