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Aliases for NPIPB15 Gene

Aliases for NPIPB15 Gene

  • Nuclear Pore Complex Interacting Protein Family Member B15 2 3 5
  • Nuclear Pore Complex Interacting Protein-Like 2 2 3
  • NPIPL2 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member B15 2
  • Nuclear Pore Complex-Interacting Protein Family Member B15 3
  • Nuclear Pore Complex-Interacting Protein-Like 2 4
  • A-761H5.4 3

External Ids for NPIPB15 Gene

Previous HGNC Symbols for NPIPB15 Gene

  • NPIPL2

Summaries for NPIPB15 Gene

GeneCards Summary for NPIPB15 Gene

NPIPB15 (Nuclear Pore Complex Interacting Protein Family Member B15) is a Protein Coding gene. An important paralog of this gene is NPIPB8.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPB15 Gene

Genomics for NPIPB15 Gene

Regulatory Elements for NPIPB15 Gene

Enhancers for NPIPB15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G074812 1.3 Ensembl ENCODE 9.7 +438.3 438292 0.6 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48 SLC30A9 ZNF143 FA2H NPIPB15 LOC105371343
GH16G075147 1.1 ENCODE 9.6 +773.7 773703 1.7 PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZFP1 NPIPB15 GC16P075140 RPS4Y1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPB15 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPB15 Gene

Chromosome:
16
Start:
74,375,001 bp from pter
End:
74,392,115 bp from pter
Size:
17,115 bases
Orientation:
Plus strand

Genomic View for NPIPB15 Gene

Genes around NPIPB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPB15 Gene

Proteins for NPIPB15 Gene

  • Protein details for NPIPB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHN6-NPB15_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member B15
    Protein Accession:
    A6NHN6
    Secondary Accessions:
    • C9J9U8

    Protein attributes for NPIPB15 Gene

    Size:
    443 amino acids
    Molecular mass:
    51267 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPB15 Gene

Post-translational modifications for NPIPB15 Gene

  • Glycosylation at posLast=111111
  • Modification sites at PhosphoSitePlus

Other Protein References for NPIPB15 Gene

No data available for DME Specific Peptides for NPIPB15 Gene

Domains & Families for NPIPB15 Gene

Protein Domains for NPIPB15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPIPB15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHN6

UniProtKB/Swiss-Prot:

NPB15_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPB15: view

No data available for Gene Families for NPIPB15 Gene

Function for NPIPB15 Gene

Phenotypes for NPIPB15 Gene

genes like me logo Genes that share phenotypes with NPIPB15: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPB15 Gene

Localization for NPIPB15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPB15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPB15 gene
Compartment Confidence
extracellular 4
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NPIPB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPB15: view

Pathways & Interactions for NPIPB15 Gene

SuperPathways for NPIPB15 Gene

No Data Available

Interacting Proteins for NPIPB15 Gene

Gene Ontology (GO) - Biological Process for NPIPB15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPB15 Gene

Drugs & Compounds for NPIPB15 Gene

No Compound Related Data Available

Transcripts for NPIPB15 Gene

mRNA/cDNA for NPIPB15 Gene

(7) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPB15 Gene

No ASD Table

Relevant External Links for NPIPB15 Gene

GeneLoc Exon Structure for
NPIPB15
ECgene alternative splicing isoforms for
NPIPB15

Expression for NPIPB15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPB15 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPB15 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for NPIPB15 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPIPB15 Gene



Protein tissue co-expression partners for NPIPB15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NPIPB15 Gene:

NPIPB15
genes like me logo Genes that share expression patterns with NPIPB15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPB15 Gene

Orthologs for NPIPB15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 89 (a)
ManyToMany
-- 35
  • 88 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 74 (a)
ManyToMany
Species where no ortholog for NPIPB15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPB15 Gene

ENSEMBL:
Gene Tree for NPIPB15 (if available)
TreeFam:
Gene Tree for NPIPB15 (if available)

Paralogs for NPIPB15 Gene

Pseudogenes.org Pseudogenes for NPIPB15 Gene

genes like me logo Genes that share paralogs with NPIPB15: view

Variants for NPIPB15 Gene

Sequence variations from dbSNP and Humsavar for NPIPB15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000204369 -- 74,390,575(+) TACAG(C/G)CATGC intron-variant
rs1000452530 -- 74,374,548(+) GTTTC(A/G)CCGTG upstream-variant-2KB
rs1000803634 -- 74,374,300(+) AAATA(A/G)ATGGC upstream-variant-2KB
rs1001177237 -- 74,383,769(+) AAATT(A/T)GCCAG intron-variant
rs1001186413 -- 74,373,668(+) TCCCT(C/T)CACCT upstream-variant-2KB

Variation tolerance for NPIPB15 Gene

Gene Damage Index Score: 5.47; 71.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPB15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPB15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NPIPB15 Gene

Disorders for NPIPB15 Gene

Relevant External Links for NPIPB15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPB15

No disorders were found for NPIPB15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPB15 Gene

Publications for NPIPB15 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 64

Products for NPIPB15 Gene

Sources for NPIPB15 Gene

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