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Aliases for NPIPA8 Gene

Aliases for NPIPA8 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A8 2 3 5
  • Morpheus Gene Family Member 9 2 3
  • Nuclear Pore Complex Interacting Protein Family, Member A8 2
  • Nuclear Pore Complex-Interacting Protein Family Member A8 3
  • LCR16a9 3

External Ids for NPIPA8 Gene

Previous GeneCards Identifiers for NPIPA8 Gene

  • GC16P016420
  • GC16M018413

Summaries for NPIPA8 Gene

GeneCards Summary for NPIPA8 Gene

NPIPA8 (Nuclear Pore Complex Interacting Protein Family Member A8) is a Protein Coding gene. An important paralog of this gene is NPIPA7.

Additional gene information for NPIPA8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA8 Gene

Genomics for NPIPA8 Gene

Regulatory Elements for NPIPA8 Gene

Enhancers for NPIPA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H019129 1.5 Ensembl ENCODE dbSUPER 13 -794.8 -794814 3 FOXA2 ATF1 FEZF1 FOS RUNX3 SP3 JUNB TSHZ1 REST ZNF518A PKD1P5 NPIPA8 SYT17 ENSG00000205746 COQ7 ENSG00000261759
GH16H018945 1.3 Ensembl ENCODE 13 -609.6 -609604 1 HDGF ATF1 ARNT DMAP1 ZNF143 ATF7 RUNX3 MXD4 JUNB TSHZ1 PKD1P5 NPIPA8 ENSG00000205746 TMC7 ARL6IP1 COQ7 ENSG00000260352
GH16H018867 0.4 ENCODE 13 -530.5 -530498 0 GTF3C2 POLR3A PKD1P5 NPIPA8 ENSG00000205746 RPS15A SMG1 LOC100996247 GC16M018804
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPA8 Gene

Chromosome:
16
Start:
18,317,919 bp from pter
End:
18,336,736 bp from pter
Size:
18,818 bases
Orientation:
Minus strand

Genomic View for NPIPA8 Gene

Genes around NPIPA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA8 Gene

Proteins for NPIPA8 Gene

  • Protein details for NPIPA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DM63-NPIA8_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member A8
    Protein Accession:
    P0DM63

    Protein attributes for NPIPA8 Gene

    Size:
    369 amino acids
    Molecular mass:
    42230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPIPA8 Gene

Post-translational modifications for NPIPA8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NPIPA8 Gene

Domains & Families for NPIPA8 Gene

Gene Families for NPIPA8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPIPA8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DM63

UniProtKB/Swiss-Prot:

NPIA8_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA8: view

No data available for Suggested Antigen Peptide Sequences for NPIPA8 Gene

Function for NPIPA8 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA8 Gene

Localization for NPIPA8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPA8 gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPIPA8 Gene

Pathways & Interactions for NPIPA8 Gene

SuperPathways for NPIPA8 Gene

No Data Available

Interacting Proteins for NPIPA8 Gene

Gene Ontology (GO) - Biological Process for NPIPA8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPA8 Gene

Drugs & Compounds for NPIPA8 Gene

No Compound Related Data Available

Transcripts for NPIPA8 Gene

mRNA/cDNA for NPIPA8 Gene

(13) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA8 Gene

No ASD Table

Relevant External Links for NPIPA8 Gene

GeneLoc Exon Structure for
NPIPA8
ECgene alternative splicing isoforms for
NPIPA8

Expression for NPIPA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPA8 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA8 Gene

This gene is overexpressed in Brain - Cerebellum (x5.3) and Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of NPIPA8 Gene:

NPIPA8
genes like me logo Genes that share expression patterns with NPIPA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPA8 Gene

Orthologs for NPIPA8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 84 (a)
OneToMany
Species where no ortholog for NPIPA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA8 Gene

ENSEMBL:
Gene Tree for NPIPA8 (if available)
TreeFam:
Gene Tree for NPIPA8 (if available)

Paralogs for NPIPA8 Gene

Variants for NPIPA8 Gene

Sequence variations from dbSNP and Humsavar for NPIPA8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000302561 -- 18,323,862(+) AAAAC(C/T)AATGC intron-variant
rs1006662207 -- 18,335,741(+) TGAAG(C/G)ATTGG upstream-variant-2KB
rs1007790182 -- 18,324,086(+) CACAT(A/C)TTACT intron-variant
rs1008173503 -- 18,329,912(+) GAAGC(C/T)GAGGT intron-variant
rs1014231090 -- 18,335,955(+) AGCTG(A/G)GACTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPIPA8 Gene

Variant ID Type Subtype PubMed ID
dgv2775n100 CNV gain 25217958
dgv2776n100 CNV gain+loss 25217958
dgv2777n100 CNV loss 25217958
dgv2781n100 CNV gain+loss 25217958
dgv2782n100 CNV loss 25217958
dgv2783n100 CNV gain 25217958
dgv2784n100 CNV gain 25217958
dgv4924n54 CNV gain 21841781
esv2714015 CNV deletion 23290073
esv2751550 CNV gain 17911159
esv2758633 CNV gain+loss 17122850
esv2758634 CNV gain+loss 17122850
esv2762276 CNV gain+loss 21179565
esv28069 CNV gain+loss 19812545
esv28183 CNV gain+loss 19812545
esv33614 CNV gain+loss 17666407
esv3382186 CNV duplication 20981092
esv3392452 CNV duplication 20981092
esv3409391 CNV duplication 20981092
esv34419 CNV gain 17911159
esv3449324 CNV duplication 20981092
esv3570398 CNV gain 25503493
esv3582069 CNV loss 25503493
esv3892799 CNV gain 25118596
nsv1043239 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1048002 CNV gain 25217958
nsv1049647 CNV gain+loss 25217958
nsv1115496 CNV duplication 24896259
nsv1124728 CNV duplication 24896259
nsv1125134 CNV deletion 24896259
nsv1139642 CNV duplication 24896259
nsv1139643 CNV duplication 24896259
nsv1147818 CNV duplication 26484159
nsv1151531 CNV duplication 26484159
nsv1160365 CNV duplication 26073780
nsv1746 CNV insertion 18451855
nsv1751 CNV deletion 18451855
nsv428319 CNV loss 18775914
nsv428320 CNV loss 18775914
nsv433436 CNV gain 18776910
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv509599 CNV insertion 20534489
nsv509601 CNV insertion 20534489
nsv7278 OTHER inversion 18451855
nsv820784 CNV deletion 20802225
nsv820818 CNV deletion 20802225
nsv952939 CNV deletion 24416366
nsv952942 CNV deletion 24416366
nsv974868 CNV duplication 23825009
nsv977920 CNV duplication 23825009
nsv977929 CNV duplication 23825009
nsv978034 CNV duplication 23825009
nsv984384 CNV duplication 23825009

Variation tolerance for NPIPA8 Gene

Gene Damage Index Score: 0.24; 5.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPA8 Gene

Disorders for NPIPA8 Gene

Relevant External Links for NPIPA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPA8

No disorders were found for NPIPA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA8 Gene

Publications for NPIPA8 Gene

  1. Positive selection of a gene family during the emergence of humans and African apes. (PMID: 11586358) Johnson ME … Eichler EE (Nature 2001) 2 3 60
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60

Products for NPIPA8 Gene

Sources for NPIPA8 Gene

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