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Aliases for NPIPA5 Gene

Aliases for NPIPA5 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A5 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member A5 2
  • Nuclear Pore Complex-Interacting Protein Family Member A5 3
  • NPIP 3

External Ids for NPIPA5 Gene

Summaries for NPIPA5 Gene

GeneCards Summary for NPIPA5 Gene

NPIPA5 (Nuclear Pore Complex Interacting Protein Family Member A5) is a Protein Coding gene. An important paralog of this gene is NPIPA1.

Additional gene information for NPIPA5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA5 Gene

Genomics for NPIPA5 Gene

Regulatory Elements for NPIPA5 Gene

Enhancers for NPIPA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H014973 1.7 FANTOM5 ENCODE dbSUPER 12.2 +406.7 406651 2.8 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000183458 PARN LOC100505915 NPIPA2 NPIPA3 ENSG00000270734 LOC105371095 BFAR RRN3 NPIPA1
GH16H015958 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -581.2 -581243 9.8 PKNOX1 TBL1XR1 SIN3A DMAP1 RARA ZNF121 EGR1 ZSCAN5C ATF7 RCOR1 ABCC1 NDE1 FOPNL ENSG00000277920 MYH11 PKD1P1 NPIPA5 GC16P016010
GH16H015792 0.8 dbSUPER 21.8 -411.7 -411707 3.4 NFIB ZNF473 INSM2 ZNF195 ZBTB40 ZNF121 ZNF366 ZNF350 ZNF680 ZNF174 ENSG00000183458 PKD1P1 LOC100505915 ENSG00000277920 NPIPA1 PKD1P6 NPIPA5 NPIPP1 FOPNL ENSG00000261819
GH16H015034 0.9 ENCODE dbSUPER 16.9 +346.7 346734 2.1 CTCF ZNF687 JUN MNT KLF4 RFX5 FOXA1 ZNF217 GATA3 POLR2A LOC100505915 NPIPA5 NPIPA1 RRN3 NPIPA2 MKL2 PIR54636 NTAN1
GH16H015024 1.1 Ensembl ENCODE dbSUPER 11.5 +356.4 356425 1.4 ZNF132 JUN ZNF398 NR2F2 ZNF121 GATA3 GLIS1 PATZ1 ZNF600 FOS NPIPA3 NPIPA5 NPIPA1 NPIPA2 ENSG00000183458 LOC100505915 GC16P015030 GC16P015031 PIR43219 GC16M015019
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPA5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NPIPA5 Gene

Genomic Locations for NPIPA5 Gene
chr16:15,363,624-15,381,972
(GRCh38/hg38)
Size:
18,349 bases
Orientation:
Minus strand
chr16:15,457,516-15,474,904
(GRCh37/hg19)

Genomic View for NPIPA5 Gene

Genes around NPIPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA5 Gene

Proteins for NPIPA5 Gene

  • Protein details for NPIPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PKD4-NPIA5_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member A5
    Protein Accession:
    E9PKD4
    Secondary Accessions:
    • Q0P618

    Protein attributes for NPIPA5 Gene

    Size:
    350 amino acids
    Molecular mass:
    40105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NPIPA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPIPA5 Gene

Post-translational modifications for NPIPA5 Gene

No Post-translational modifications

Other Protein References for NPIPA5 Gene

No data available for DME Specific Peptides for NPIPA5 Gene

Domains & Families for NPIPA5 Gene

Gene Families for NPIPA5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NPIPA5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

E9PKD4

UniProtKB/Swiss-Prot:

NPIA5_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA5: view

No data available for Suggested Antigen Peptide Sequences for NPIPA5 Gene

Function for NPIPA5 Gene

Phenotypes From GWAS Catalog for NPIPA5 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA5 Gene

Localization for NPIPA5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPA5 gene
Compartment Confidence
nucleus 4
plasma membrane 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NPIPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NPIPA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPIPA5 Gene

Pathways & Interactions for NPIPA5 Gene

SuperPathways for NPIPA5 Gene

No Data Available

Interacting Proteins for NPIPA5 Gene

Gene Ontology (GO) - Biological Process for NPIPA5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPIPA5 Gene

Drugs & Compounds for NPIPA5 Gene

No Compound Related Data Available

Transcripts for NPIPA5 Gene

mRNA/cDNA for NPIPA5 Gene

(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA5 Gene

No ASD Table

Relevant External Links for NPIPA5 Gene

GeneLoc Exon Structure for
NPIPA5
ECgene alternative splicing isoforms for
NPIPA5

Expression for NPIPA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPIPA5 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA5 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of NPIPA5 Gene:

NPIPA5

Evidence on tissue expression from TISSUES for NPIPA5 Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with NPIPA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPIPA5 Gene

Orthologs for NPIPA5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 83 (a)
OneToMany
Species where no ortholog for NPIPA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA5 Gene

ENSEMBL:
Gene Tree for NPIPA5 (if available)
TreeFam:
Gene Tree for NPIPA5 (if available)

Paralogs for NPIPA5 Gene

Variants for NPIPA5 Gene

Sequence variations from dbSNP and Humsavar for NPIPA5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs886037884 Uncertain significance 15,363,750(-) AGCTC(C/T)ACCCT intron-variant, downstream-variant-500B, reference, missense
rs1000286020 -- 15,383,376(+) TTCCA(C/T)TGCGT upstream-variant-2KB
rs1000550905 -- 15,369,972(+) CCTTT(A/C)CAGGG intron-variant
rs1000876498 -- 15,382,139(+) GAGGG(C/T)CACAT upstream-variant-2KB
rs1000929824 -- 15,376,117(+) AAAAG(A/G)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPIPA5 Gene

Variant ID Type Subtype PubMed ID
nsv984269 CNV duplication 23825009
nsv974862 CNV duplication 23825009
nsv833146 CNV gain 17160897
nsv833145 CNV gain 17160897
nsv511045 OTHER complex 20534489
nsv435664 CNV deletion 17901297
nsv1148675 CNV duplication 26484159
nsv1125134 CNV deletion 24896259
nsv1120319 CNV tandem duplication 24896259
nsv1115493 CNV duplication 24896259
nsv1045440 CNV gain 25217958
nsv1038151 CNV loss 25217958
esv27929 CNV gain 19812545
esv2714015 CNV deletion 23290073
dgv2755n100 CNV gain 25217958

Variation tolerance for NPIPA5 Gene

Gene Damage Index Score: 4.84; 67.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPA5 Gene

Disorders for NPIPA5 Gene

Relevant External Links for NPIPA5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPA5

No disorders were found for NPIPA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA5 Gene

Publications for NPIPA5 Gene

  1. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  2. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PMID: 18055785) Hornan DM … Webster AR (Investigative ophthalmology & visual science 2007) 3 60
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang AG … Kim NS (Biochemical and biophysical research communications 2006) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60

Products for NPIPA5 Gene

Sources for NPIPA5 Gene

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