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Aliases for NPIPA1 Gene

Aliases for NPIPA1 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A1 2 3 5
  • Nuclear Pore Complex Interacting Protein Family, Member A1 2 3
  • NPIP 3 4
  • Nuclear Pore Complex-Interacting Protein A Type 3
  • Nuclear Pore Complex Interacting Protein 2
  • Nuclear Pore Complex-Interacting Protein 4
  • Morpheus 3
  • NPIPA 3

External Ids for NPIPA1 Gene

Previous HGNC Symbols for NPIPA1 Gene

  • NPIP

Previous GeneCards Identifiers for NPIPA1 Gene

  • GC16P015024
  • GC16P015029

Summaries for NPIPA1 Gene

GeneCards Summary for NPIPA1 Gene

NPIPA1 (Nuclear Pore Complex Interacting Protein Family Member A1) is a Protein Coding gene. An important paralog of this gene is NPIPB11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA1 Gene

Genomics for NPIPA1 Gene

Regulatory Elements for NPIPA1 Gene

Enhancers for NPIPA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPIPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPA1 Gene

14,750,813 bp from pter
14,952,074 bp from pter
201,262 bases
Plus strand

Genomic View for NPIPA1 Gene

Genes around NPIPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA1 Gene

Proteins for NPIPA1 Gene

  • Protein details for NPIPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex-interacting protein family member A1
    Protein Accession:
    Secondary Accessions:
    • O15102

    Protein attributes for NPIPA1 Gene

    350 amino acids
    Molecular mass:
    40133 Da
    Quaternary structure:
    • May associate with the nuclear pore complex.

neXtProt entry for NPIPA1 Gene

Proteomics data for NPIPA1 Gene at MOPED

Post-translational modifications for NPIPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPIPA1 Gene

No data available for DME Specific Peptides for NPIPA1 Gene

Domains & Families for NPIPA1 Gene

Protein Domains for NPIPA1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NPIP family.
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NPIPA1 Gene

Function for NPIPA1 Gene

genes like me logo Genes that share phenotypes with NPIPA1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA1 Gene

Localization for NPIPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPA1 Gene

Nucleus, nuclear pore complex. Nucleus membrane. Note=Colocalizes with nuclear pore complex protein NUP62.

Gene Ontology (GO) - Cellular Components for NPIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPIPA1: view

No data available for Subcellular locations from COMPARTMENTS for NPIPA1 Gene

Pathways & Interactions for NPIPA1 Gene

SuperPathways for NPIPA1 Gene

No Data Available

Interacting Proteins for NPIPA1 Gene

Gene Ontology (GO) - Biological Process for NPIPA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NPIPA1 Gene

Drugs & Compounds for NPIPA1 Gene

No Compound Related Data Available

Transcripts for NPIPA1 Gene

mRNA/cDNA for NPIPA1 Gene

(7) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA1 Gene

No ASD Table

Relevant External Links for NPIPA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPIPA1 Gene

mRNA expression in normal human tissues for NPIPA1 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.8).

mRNA Expression by UniProt/SwissProt for NPIPA1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NPIPA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPIPA1 Gene

Orthologs for NPIPA1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 83 (a)
Species with no ortholog for NPIPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA1 Gene

Gene Tree for NPIPA1 (if available)
Gene Tree for NPIPA1 (if available)

Paralogs for NPIPA1 Gene

genes like me logo Genes that share paralogs with NPIPA1: view

Variants for NPIPA1 Gene

Sequence variations from dbSNP and Humsavar for NPIPA1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_034141 -
rs62038518 -- 14,934,286(+) CGTCT(A/C)CAAAA upstream-variant-2KB
rs62038519 -- 14,934,537(+) TAAGC(C/T)GCGAC upstream-variant-2KB
rs62038520 -- 14,935,324(+) GACTC(A/C)AGACC utr-variant-5-prime
rs62038521 -- 14,935,329(+) AAGAC(A/C)CTGTG utr-variant-5-prime

Variation tolerance for NPIPA1 Gene

Gene Damage Index Score: 0.72; 15.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NPIPA1 Gene

Disorders for NPIPA1 Gene

Relevant External Links for NPIPA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NPIPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA1 Gene

Publications for NPIPA1 Gene

  1. Positive selection of a gene family during the emergence of humans and African apes. (PMID: 11586358) Johnson M.E. … Eichler E.E. (Nature 2001) 2 3 4 67
  2. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PMID: 18055785) Hornan D.M. … Webster A.R. (Invest. Ophthalmol. Vis. Sci. 2007) 2 3 23
  3. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NPIPA1 Gene

Sources for NPIPA1 Gene