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Aliases for NPIPA1 Gene

Aliases for NPIPA1 Gene

  • Nuclear Pore Complex Interacting Protein Family Member A1 2 3 5
  • NPIP 3 4
  • Nuclear Pore Complex Interacting Protein Family, Member A1 2
  • Nuclear Pore Complex-Interacting Protein Family Member A1 3
  • Nuclear Pore Complex-Interacting Protein A Type 3
  • Nuclear Pore Complex Interacting Protein 2
  • Nuclear Pore Complex-Interacting Protein 4
  • Morpheus 3
  • NPIPA 3

External Ids for NPIPA1 Gene

Previous HGNC Symbols for NPIPA1 Gene

  • NPIP

Previous GeneCards Identifiers for NPIPA1 Gene

  • GC16P015024
  • GC16P015029
  • GC16P014750

Summaries for NPIPA1 Gene

GeneCards Summary for NPIPA1 Gene

NPIPA1 (Nuclear Pore Complex Interacting Protein Family Member A1) is a Protein Coding gene. An important paralog of this gene is NPIPA2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPIPA1 Gene

Genomics for NPIPA1 Gene

Regulatory Elements for NPIPA1 Gene

Enhancers for NPIPA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F015588 1.9 FANTOM5 Ensembl ENCODE 5.8 +668.5 668521 5.4 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF548 ZNF263 SP3 TBX21 MEF2D BFAR ENSG00000263335 LOC100505915 RRN3 PKD1P6 RPL17P40 ENSG00000270734 LOC105371095 ENSG00000263029 NDE1
GH16F015517 1.7 FANTOM5 Ensembl ENCODE 5 +598.2 598150 6.5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 SLC30A9 SP5 MXD4 C16orf45 KIAA0430 RPL17P40 ENSG00000270734 LOC105371095 ENSG00000263029 BFAR LOC100505915 PKD1P6 RRN3
GH16F015575 1.4 FANTOM5 ENCODE 5 +653.8 653824 2.6 ARNT CREB3L1 MLX FEZF1 DMAP1 YY1 FOS SP5 NFYC ZHX2 ENSG00000263335 BFAR C16orf45 NPIPA1 PIR41816 PIR47709
GH16F015034 0.7 ENCODE 9.1 +112.4 112437 2.1 CTCF ZNF687 JUN MNT KLF4 GATA3 POLR2A KLF9 ZBTB33 MYC LOC100505915 NPIPA5 NPIPA1 RRN3 NPIPA2 MKL2 PIR54636 NTAN1
GH16F015501 1.2 Ensembl ENCODE 5.2 +579.5 579504 2.0 PKNOX1 ATF1 SIN3A ZNF2 FOS TSHZ1 ZNF518A SMARCA4 PBX2 GLIS1 C16orf45 MPV17L NPIPA1 LOC105371102
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPIPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPIPA1 Gene

Chromosome:
16
Start:
14,922,802 bp from pter
End:
14,952,074 bp from pter
Size:
29,273 bases
Orientation:
Plus strand

Genomic View for NPIPA1 Gene

Genes around NPIPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPIPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPIPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPIPA1 Gene

Proteins for NPIPA1 Gene

  • Protein details for NPIPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UND3-NPIA1_HUMAN
    Recommended name:
    Nuclear pore complex-interacting protein family member A1
    Protein Accession:
    Q9UND3
    Secondary Accessions:
    • O15102

    Protein attributes for NPIPA1 Gene

    Size:
    350 amino acids
    Molecular mass:
    40133 Da
    Quaternary structure:
    • May associate with the nuclear pore complex.

neXtProt entry for NPIPA1 Gene

Post-translational modifications for NPIPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPIPA1 Gene

No data available for DME Specific Peptides for NPIPA1 Gene

Domains & Families for NPIPA1 Gene

Protein Domains for NPIPA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPIPA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UND3

UniProtKB/Swiss-Prot:

NPIA1_HUMAN :
  • Belongs to the NPIP family.
Family:
  • Belongs to the NPIP family.
genes like me logo Genes that share domains with NPIPA1: view

No data available for Gene Families for NPIPA1 Gene

Function for NPIPA1 Gene

genes like me logo Genes that share phenotypes with NPIPA1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPIPA1 Gene

Localization for NPIPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPIPA1 Gene

Nucleus, nuclear pore complex. Nucleus membrane. Note=Colocalizes with nuclear pore complex protein NUP62.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPIPA1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NPIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NPIPA1: view

Pathways & Interactions for NPIPA1 Gene

SuperPathways for NPIPA1 Gene

No Data Available

Interacting Proteins for NPIPA1 Gene

Gene Ontology (GO) - Biological Process for NPIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NPIPA1: view

No data available for Pathways by source and SIGNOR curated interactions for NPIPA1 Gene

Transcripts for NPIPA1 Gene

mRNA/cDNA for NPIPA1 Gene

(6) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPIPA1 Gene

No ASD Table

Relevant External Links for NPIPA1 Gene

GeneLoc Exon Structure for
NPIPA1
ECgene alternative splicing isoforms for
NPIPA1

Expression for NPIPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPIPA1 Gene

mRNA differential expression in normal tissues according to GTEx for NPIPA1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of NPIPA1 Gene:

NPIPA1

mRNA Expression by UniProt/SwissProt for NPIPA1 Gene:

Q9UND3-NPIA1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NPIPA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPIPA1 Gene

Orthologs for NPIPA1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 83 (a)
OneToMany
Species where no ortholog for NPIPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPIPA1 Gene

ENSEMBL:
Gene Tree for NPIPA1 (if available)
TreeFam:
Gene Tree for NPIPA1 (if available)

Paralogs for NPIPA1 Gene

Variants for NPIPA1 Gene

Sequence variations from dbSNP and Humsavar for NPIPA1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1059233 -- 14,952,002(+) CTCAG(A/C/T)GGATG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense, utr-variant-3-prime
rs111795693 -- 14,938,776(+) TTCTG(C/T)CGCCC intron-variant
rs112252810 -- 14,936,867(+) TGGAC(A/G)TCCCT intron-variant, upstream-variant-2KB
rs113355765 -- 14,945,634(+) ATGTA(A/C)AGCAG nc-transcript-variant, reference, missense
rs1136474 -- 14,945,658(+) CCAAC(C/T)GCCGT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NPIPA1 Gene

Variant ID Type Subtype PubMed ID
esv2762254 CNV gain+loss 21179565
esv2760416 CNV gain+loss 21179565
esv2758633 CNV gain+loss 17122850
esv2758632 CNV gain+loss 17122850
esv2714015 CNV deletion 23290073
esv2631582 CNV gain 19546169
esv22206 CNV gain+loss 19812545
dgv791e212 CNV loss 25503493
dgv4924n54 CNV gain 21841781
dgv4920n54 CNV loss 21841781
dgv4919n54 CNV loss 21841781
dgv2n1 OTHER inversion 15895083
dgv2777n100 CNV loss 25217958
dgv2776n100 CNV gain+loss 25217958
dgv2775n100 CNV gain 25217958
dgv2757n100 CNV gain+loss 25217958
dgv2756n100 CNV loss 25217958
dgv2755n100 CNV gain 25217958
dgv2754n100 CNV loss 25217958
dgv2753n100 CNV loss 25217958
dgv2752n100 CNV gain+loss 25217958
dgv2751n100 CNV gain 25217958
dgv2750n100 CNV loss 25217958
dgv2749n100 CNV gain 25217958
dgv2747n100 CNV loss 25217958
dgv2746n100 CNV gain+loss 25217958
dgv2745n100 CNV gain 25217958
dgv2744n100 CNV loss 25217958
dgv2742n100 CNV gain 25217958
dgv2741n100 CNV gain+loss 25217958
dgv2740n100 CNV loss 25217958
dgv2738n100 CNV gain 25217958
dgv112n111 CNV duplication 26073780
dgv111n111 CNV duplication 26073780
nsv978034 CNV duplication 23825009
nsv977920 CNV duplication 23825009
nsv974762 CNV duplication 23825009
nsv952939 CNV deletion 24416366
nsv952931 CNV duplication 24416366
nsv952930 CNV deletion 24416366
nsv9356 CNV gain 18304495
nsv820818 CNV deletion 20802225
nsv819280 CNV loss 19587683
nsv7277 OTHER inversion 18451855
nsv511045 OTHER complex 20534489
nsv509599 CNV insertion 20534489
nsv499138 OTHER inversion 21111241
nsv499081 OTHER inversion 21111241
nsv471384 CNV gain 19718026
nsv457428 CNV gain 19166990
nsv442710 CNV gain 18776908
nsv435664 CNV deletion 17901297
nsv433435 CNV gain 18776910
nsv428319 CNV loss 18775914
nsv1746 CNV insertion 18451855
nsv136 OTHER inversion 15895083
nsv1160346 CNV duplication 26073780
nsv1160345 CNV duplication 26073780
nsv1160344 CNV deletion 26073780
nsv1151531 CNV duplication 26484159
nsv1146292 CNV duplication 26484159
nsv1141278 CNV duplication 24896259
nsv1139642 CNV duplication 24896259
nsv1125134 CNV deletion 24896259
nsv1110265 CNV duplication 24896259
nsv1076419 CNV duplication 25765185
nsv1049647 CNV gain+loss 25217958
nsv1048002 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1038955 CNV loss 25217958
esv3892799 CNV gain 25118596
esv3584701 CNV loss 24956385
esv3570398 CNV gain 25503493
esv3570331 CNV gain 25503493
esv3425948 CNV duplication 20981092
esv3392452 CNV duplication 20981092
esv33614 CNV gain+loss 17666407
esv32598 CNV gain 17666407
esv28069 CNV gain+loss 19812545
esv2762276 CNV gain+loss 21179565

Variation tolerance for NPIPA1 Gene

Gene Damage Index Score: 0.72; 15.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPIPA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPIPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPIPA1 Gene

Disorders for NPIPA1 Gene

Relevant External Links for NPIPA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPIPA1

No disorders were found for NPIPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPIPA1 Gene

Publications for NPIPA1 Gene

  1. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PMID: 18055785) Hornan D.M. … Webster A.R. (Invest. Ophthalmol. Vis. Sci. 2007) 2 3 22 64
  2. Positive selection of a gene family during the emergence of humans and African apes. (PMID: 11586358) Johnson M.E. … Eichler E.E. (Nature 2001) 2 3 4 64
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4 64
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3 64
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3 64

Products for NPIPA1 Gene

Sources for NPIPA1 Gene

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