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NPIPA1 Gene

protein-coding   GIFtS: 34
GCID: GC16P015029

Nuclear Pore Complex Interacting Protein Family, Member...

(Previous name: nuclear pore complex interacting protein)
(Previous symbol: NPIP)
  Search for NPIPA1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Pore Complex Interacting Protein Family, Member A11 2
NPIP1 2 3 5
Nuclear Pore Complex Interacting Protein1
morpheus2
Nuclear Pore Complex-Interacting Protein Family Member A12
Nuclear Pore Complex-Interacting Protein3

External Ids:    HGNC: 79091   Entrez Gene: 92842   Ensembl: ENSG000001834267   OMIM: 6064065   UniProtKB: Q9UND33   

Export aliases for NPIPA1 gene to outside databases

Previous GC identifer: GC16P015024


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPIPA1 Gene:
NPIPA1 (nuclear pore complex interacting protein family, member A1) is a protein-coding gene. An important paralog of this gene is LOC440353.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NPIPA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPIPA1 promoter sequence
   Search Chromatin IP Primers for NPIPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPIPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.11   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.11

NPIPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPIPA1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P015029:  view genomic region     (about GC identifiers)

Start:
15,016,659 bp from pter      End:
15,045,931 bp from pter
Size:
29,273 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPIA1_HUMAN, Q9UND3 (See protein sequence)
Recommended Name: Nuclear pore complex-interacting protein family member A1  
Size: 350 amino acids; 40133 Da
Subunit: May associate with the nuclear pore complex
Secondary accessions: O15102

Explore the universe of human proteins at neXtProt for NPIPA1: NX_Q9UND3

Explore proteomics data for NPIPA1 at MOPED


See NPIPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008916.2  
ENSEMBL proteins: 
 ENSP00000331843   ENSP00000410814   ENSP00000445593  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR009443 NPIP

Graphical View of Domain Structure for InterPro Entry Q9UND3

ProtoNet protein and cluster: Q9UND3

UniProtKB/Swiss-Prot: NPIA1_HUMAN, Q9UND3
Similarity: Belongs to the NPIP family


Find genes that share domains with NPIPA1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for NPIPA1:
 Low eccentricity cells 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NPIA1_HUMAN, Q9UND3: Nucleus, nuclear pore complex. Nucleus membrane. Note=Colocalizes with nuclear pore complex
protein NUP62

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005643nuclear pore IEA--
GO:0031965nuclear membrane IEA--

Find genes that share ontologies with NPIPA1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPIPA1
Interactions:

    Search GeneGlobe Interaction Network for NPIPA1

1 Interacting protein for NPIPA1 (Q9UND33) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
FOSP011003I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015031protein transport IEA--
GO:0051028mRNA transport IEA--

Find genes that share ontologies with NPIPA1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NPIPA1 (NPIA1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NPIPA1 gene: 
NM_006985.2  

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000472413(uc010uzk.2 uc002dcx.4) ENST00000541836 ENST00000545831
ENST00000328085(uc002dcy.4) ENST00000424549 ENST00000545479 ENST00000534720
ENST00000537062
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3 AceView cDNA sequences:

BE699221 CB123100 NM_006985 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NPIPA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NPIPA1 Expression
About this image

NPIPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NPIPA1 Protein Expression

UniProtKB/Swiss-Prot: NPIA1_HUMAN, Q9UND3
Tissue specificity: Widely expressed

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for NPIPA1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia --
Uncharacterized protein
83(a)
1 → many
GL392393.1(966-7814)


ENSEMBL Gene Tree for NPIPA1 (if available)
TreeFam Gene Tree for NPIPA1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NPIPA1 gene
NPIPA31 2  NPIPA81 2  NPIPA71 2  NPIPA21 2  NPIPA51 2  LOC4403532  NPIPB92  PKD1P12  
ENSG000002330242  NPIPB152  NPIPB32  LOC1019299102  LOC7299782  NPIPB52  LOC7301532  NPIPB112  
NPIPB82  NPIPB42  NPIPB72  NPIPB62  
Selected SIMAP similar genes for NPIPA1 using alignment to 6 protein entries:     NPIA1_HUMAN (see all proteins) (see all similar genes):
Nbla00537    NPIPA3    NPIPA2    LOC339047    NPIPA5    A-589H1.1
NPIPA7    NPIPA8    A-575C2.4    LOC101929910    NPIPB5    NPIPB4
NPIPB3    NPIPB11    NPIPB15    NPIPB8    A-761H5.4    NPIPB7

Find genes that share paralogs with NPIPA1           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for NPIPA1 (see all 8)
PGOHUM00000257997 PGOHUM00000259019 PGOHUM00000261201 PGOHUM00000258006 PGOHUM00000261207


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NPIPA1 (see all 89)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1995145831,2
C--15034231(+) TGCATC/GCAATG 1 -- int10--------
rs1499805321,2
--15034279(+) GATAAC/TTACTG 1 -- int10--------
rs2005721401,2
C--15034435(+) GGCAGA/GCGCCT 1 -- int10--------
rs1930511861,2
C--15036308(+) GAGGGG/TAGAGG 1 -- int10--------
rs575602381,2
C--15039006(+) CAGGTG/TATCCG 1 -- int10--------
rs169546191,2
C--15041103(-) TTAAAT/CATTTT 1 -- int12Minor allele frequency- C:0.35MN NA 186
rs1831115171,2
--15044517(+) GACTTA/GTACAC 1 -- int10--------
rs1882003781,2
C--15044528(+) TTGAAA/GTGAAA 1 -- int10--------
rs1998427701,2
C--15045595(+) ATTCTA/GTAATT 2 I V mis11Minor allele frequency- G:0.00EU 1281
rs2010842061,2
C,F--15045628(+) CACCTT/CCGAGT 2 /P /S mis11Minor allele frequency- C:0.02EU 973

HapMap Linkage Disequilibrium report for NPIPA1 (15016659 - 15045931 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NPIPA1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NPIPA1
DNA2.0 Custom Variant and Variant Library Synthesis for NPIPA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606406    OMIM disorders: --


Find genes that share disorders with NPIPA1           About GenesLikeMe


Export disorders for NPIPA1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NPIPA1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NPIPA1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Positive selection of a gene family during the emergence of humans and African apes. (PubMed id 11586358)1, 2, 3 Johnson M.E.... Eichler E.E. (Nature 2001)
  2. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PubMed id 18055785)1, 3, 9 Hornan D.M....Webster A.R. (amp 2007)
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
  4. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
  6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Effects of lysophosphatidyl choline and phospholipase A on the lens. (PubMed id 1158635)1 Cotlier E....Kresca L. (Invest Ophthalmol 1975)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9284 HGNC: 7909 AceView: NPIP.1 Ensembl:ENSG00000183426 euGenes: HUgn9284
ECgene: NPIPA1 H-InvDB: NPIPA1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NPIPA1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NPIPA1 gene:
Search GeneIP for patents involving NPIPA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPIPA1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for NPIPA1
 SwitchGear Promoter luciferase reporter plasmids for NPIPA1
 ThermoFisher Antibodies for NPIPA1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIPA1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPIPA1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NPIPA1
 LSBio Antibodies in human, mouse, rat for NPIPA1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for NPIPA1
  Search eBioscience for proteins for NPIPA1
  Search eBioscience for elisas for NPIPA1
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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