NPIP Gene
protein-coding GIFtS: 41
GCID: GC16P015017
|
|
nuclear pore complex interacting protein
| |
Aliases
for NPIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Pore Complex Interacting Protein1 2 | | Morpheus1 | | Nuclear Pore Complex-Interacting Protein2 |
Export aliases for NPIP gene to outside databasesPrevious GC identifers: GC16P014754 GC16P015695 GC16P014951 GC16P014997 GC16P016397 GC16P014930 GC16P014938 GC16M014840 GC16P014844 |
Summaries
for NPIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NPIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPIP gene promoter:
Max1 GATA-3 Arnt c-Ets-1 HEN1 Pax-3 PPAR-gamma1 SEF-1 (1) PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11NPIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P015017: view genomic region
(about GC identifiers)
Start:
|
15,016,659 bp from pter |
End:
|
15,045,931 bp from pter |
Size:
|
29,273 bases |
Orientation:
|
plus strand |
|
Proteins
for NPIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPIP_HUMAN, Q9UND3 (See
protein sequence)Recommended Name: Nuclear pore complex-interacting protein Size: 350 amino acids; 40133 Da
Subunit: May associate with the nuclear pore complex
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane. Note=Colocalizes with nuclear pore complexprotein NUP62
Secondary accessions: O15102Explore the universe of human proteins at neXtProt for NPIP: NX_Q9UND3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UND3
NPIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008916.2
ENSEMBL proteins: ENSP00000331843 ENSP00000410814 ENSP00000445593
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005643 | nuclear pore |
IEA | -- | | GO:0031965 | nuclear membrane |
IEA | -- |
NPIP for ontologies About GeneDecksing
NPIP Antibody Products:
Assay Products for NPIP: |
Protein
Domains /
Families
for NPIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UND3ProtoNet protein and cluster: Q9UND3 UniProtKB/Swiss-Prot: NPIP_HUMAN, Q9UND3Similarity: Belongs to the NPIP family |
Function
for NPIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPIP (NM_006985) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIP |
1 GenomeRNAi human phenotype for NPIP:
|
Pathways & Interactions
for NPIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPIP
1 Interacting protein for NPIP (Q9UND33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0051028 | mRNA transport |
IEA | -- |
NPIP for ontologies About GeneDecksing
|
Drugs & Compounds
for NPIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPIP
Search CenterWatch for drugs/clinical trials and news about NPIP
|
Transcripts
for NPIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPIP gene: NM_006985.2 Unigene Cluster for NPIP: Nuclear pore complex interacting protein Hs.676266 [show with all ESTs]Unigene Representative Sequence: BI5210148 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000472413(uc010uzk.2 uc002dcx.4) ENST00000541836 ENST00000545831
ENST00000328085(uc002dcy.4) ENST00000424549 ENST00000545479 ENST00000534720
ENST00000537062
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPIP (NM_006985) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIP |
Additional cDNA sequence: AF132984.1 AK294177.1 XR_158889.1 XR_172129.1 24/86 DOTS entries (see all 86): DT.100892057 DT.102841256 DT.120707777 DT.91970940 DT.95298390 DT.120663321 DT.87018122 DT.120707722 DT.100892055 DT.91912754 DT.120707718 DT.92010540 DT.95298351 DT.91948088 DT.95338839 DT.97856800 DT.102841880 DT.75150160 DT.100892098 DT.101985692 DT.120707771 DT.102841948 DT.120663250 DT.120692219 3 AceView cDNA sequences: CB123100 BE699221 NM_006985
GeneLoc Exon Structure
|
Expression
for NPIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NPIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPIP
SOURCE GeneReport for Unigene cluster: Hs.676266
UniProtKB/Swiss-Prot: NPIP_HUMAN, Q9UND3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for NPIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPIP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NPIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIP |
Orthologs
for NPIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NPIP (if available)
TreeFam Gene Tree for NPIP (if available) |
Paralogs
for NPIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NPIP gene
- LOC6427781 2 LOC6427991 2 LOC1002883321 2 LOC4403532 LOC7288882 ENSG000002149402 ENSG000001980642 LOC7287412
- NPIPL12 61E3.42 PKD1P12 NPIPL22 ENSG000002149672 LOC1005076072 ENSG000002262322 NPIPL32
- LOC7299782 LOC7301532 ENSG000001969932 LOC6130372
16 SIMAP similar genes for NPIP using alignment to 4 protein entries: NPIP_HUMAN (see all proteins):Nbla00537 PKD1 PKD1P1 LOC642778 A-589H1.1 LOC339047
NPIPP1 A-575C2.4 61E3.4 NPIPL3 LOC728888 NPIPL2
LOC728741 A-761H5.4 NPIPL1 LOC728734
NPIP for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for NPIP (see all 8)
PGOHUM00000257997 PGOHUM00000259019 PGOHUM00000261201 PGOHUM00000258006 PGOHUM00000261207
|
Genomic Variants
for NPIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPIP (15016659 - 15045931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for NPIP
14 CNVs: 3992 87981 30742 102217 58749 77203 7088 37572 87979 72476 87978 77200 37843 77199
5 Inversions: 0478 0477 37175 37176 0479 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPIP |
|
Disorders
/ Diseases
for NPIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPIP for disorders About GeneDecksing
OMIM gene information: 606406
OMIM disorders: --
5  diseases for NPIP: About MalaCardsnasopharynx carcinoma esophageal cancer esophagitis retinitis
carcinoma
Export disorders for NPIP gene to outside databases
|
Publications
for NPIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPIP gene integrated from 9 sources:
(articles sorted by number of sources associating them with NPIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Positive selection of a gene family during the emergence of humans and African apes. (PubMed id 11586358)1, 2, 3 Johnson M.E.... Eichler E.E. (2001)
- Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. (PubMed id 18055785)1, 3, 9 Hornan D.M....Webster A.R. (2007)
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Effects of lysophosphatidyl choline and phospholipase A on the lens. (PubMed id 1158635)1 Cotlier E....Kresca L. (1975)
|
External Searches for NPIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPIP gene:
Search GeneIP for patents involving NPIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPIP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPIP | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPIP | | OriGene Custom Protein Services for NPIP | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPIP |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NPIP |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NPIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for NPIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPIP |
|
|
|
|
