NPHP4 Gene
protein-coding GIFtS: 55
GCID: GC01M005922
|
|
nephronophthisis 4
| |
Aliases
for NPHP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nephronophthisis 41 2 | | Nephrocystin-41 | | SLSN41 2 5 | | Nephroretinin3 | | POC101 2 | | POC10 Centriolar Protein Homolog2 | | KIAA06731 3 | | Nephroretinin3 |
Export aliases for NPHP4 gene to outside databasesPrevious GC identifers: GC01U990494 GC01M005731 GC01M005519 GC01M005632 GC01M005858 GC01M005071 |
Summaries
for NPHP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NPHP4:
This gene encodes a protein involved in renal tubular development and function. This protein interacts withnephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures.Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrometype 4, a combination of nephronophthisis and retinitis pigmentosa. (provided by RefSeq, Feb 2010)
UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161Function: Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (Bysimilarity). Does not seem to be strictly required for ciliogenesis (By similarity)
Gene Wiki entry for NPHP4
|
Genomic Views
for NPHP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPHP4 gene promoter:
Max1 AP-1 NRSF form 1 NRSF form 2 HEN1 Cart-1 TGIF RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPHP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPHP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36NPHP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M005922: view genomic region
(about GC identifiers)
Start:
|
5,922,870 bp from pter |
End:
|
6,052,533 bp from pter |
Size:
|
129,664 bases |
Orientation:
|
minus strand |
|
Proteins
for NPHP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161 (See
protein sequence)Recommended Name: Nephrocystin-4 Size: 1426 amino acids; 157598 Da
Subunit: Interacts with NPHP1 and RPGRIP1L/NPHP8, and can bridge the interaction between those two proteins. Interactswith IQCB1; the interaction likely requires additional interactors. Interacts with RPGRIP1. Weakly interacts withCEP164
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, centrosome. Cell junction,tight junction. Note=In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approachconfluence, it accumulates to basolateral tight junctionsExplore the universe of human proteins at neXtProt for NPHP4: NX_O75161
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75161
NPHP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055917.1
ENSEMBL proteins: ENSP00000423747 ENSP00000367398 ENSP00000367411 ENSP00000425745 Reactome Protein details: O75161
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
NPHP4 for ontologies About GeneDecksing
NPHP4 Antibody Products:
Assay Products for NPHP4: |
Protein
Domains /
Families
for NPHP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O75161 UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161Similarity: Belongs to the NPHP4 family |
Function
for NPHP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161Function: Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (Bysimilarity). Does not seem to be strictly required for ciliogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPHP4 (NM_015102) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPHP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPHP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPHP4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NPHP4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NPHP4:
Animal Models:
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nphp4):
NPHP4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NPHP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by Hippo | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for NPHP4
NPHP4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPHP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for NPHP4 (O751613 ENSP000003673984) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
NPHP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for NPHP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPHP4
Search CenterWatch for drugs/clinical trials and news about NPHP4
|
Transcripts
for NPHP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPHP4 gene: NM_015102.3 Unigene Cluster for NPHP4: Nephronophthisis 4 Hs.462348 [show with all ESTs]Unigene Representative Sequence: NM_01510210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460696 ENST00000378161(uc001alr.1) ENST00000478423 ENST00000489180(uc001alq.2 uc001als.2 uc009vlt.2)
ENST00000378156(uc001alt.2) ENST00000378169 ENST00000468253 ENST00000506941
ENST00000470763 ENST00000466897(uc009vlu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPHP4 (NM_015102) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPHP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPHP4 |
Additional cDNA sequence: AB014573.1 AF537130.1 AK124074.1 AK314326.1 AL117405.1 AY118228.1 13 DOTS entries: DT.75101759 DT.95241364 DT.97841747 DT.95370268 DT.100778179 DT.95076155 DT.101982051 DT.92419507 DT.121349976 DT.40246923 DT.101969066 DT.452418 DT.95261886 24/100 AceView cDNA sequences (see all 100): AK127333 BM803649 BU629376 BM756854 R13139 BM742505 CA308202 BM770843 Z38915 AW189665 AW338245 BM744331 AW136203 BU621804 BM756774 BQ223937 CB145636 BM741440 AK124074 AF537130 BX642079 BC050076 BM757055 AY118228
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NPHP4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NPHP4
|
Expression
for NPHP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPHP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NPHP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPHP4
SOURCE GeneReport for Unigene cluster: Hs.462348
UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161Tissue specificity: Expressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung
SABiosciences Custom PCR Arrays for NPHP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPHP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPHP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPHP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPHP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPHP4 |
Orthologs
for NPHP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NPHP4 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for NPHP4 (if available)
TreeFam Gene Tree for NPHP4 (if available) |
Paralogs
for NPHP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NPHP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPHP4 (5922870 - 6052533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NPHP4
2 CNVs: 4199 4198
1 Indel: 11022
Human Gene Mutation Database (HGMD): NPHP4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPHP4 |
|
Disorders
/ Diseases
for NPHP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPHP4 for disorders About GeneDecksing
OMIM gene information: 607215
OMIM disorders: 606966 606996
UniProtKB/Swiss-Prot: NPHP4_HUMAN, O75161
Defects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4) [MIM:606966]; also known as familialjuvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease atage ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized bypolydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of thetubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts Note=Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlappingclinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of variousorgan, and a complex range of anatomical and functional defects of the central and peripheral nervous system. Theciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome,nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelismis insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion thatvariations across multiple sites of the ciliary proteome, including NPHP4, influence the clinical outcome Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4) [MIM:606996]. SLSN is a renal-retinaldisorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cysticrenal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life
20/32  diseases for NPHP4 (see all 32): About MalaCardssenior-loken syndrome nephronophthisis retinitis pigmentosa nephronophthisis 4
open-angle glaucoma senior-loken syndrome 4 cone-rod dystrophy familial juvenile hyperuricemic nephropathy
primary open angle glaucoma end stage renal failure bardet-biedl syndrome retinitis
asphyxiating thoracic dystrophy focal segmental glomerulosclerosis cogan's syndrome leber congenital amaurosis
situs inversus hyperuricemic nephropathy cystic kidney nephronopthisis
5 diseases from the University of Copenhagen DISEASES database for NPHP4:Nephronophthisis Cystic kidney End stage renal failure Familial juvenile hyperuricemic nephropathy
Retinitis pigmentosa 8 Novoseek disease relationships for NPHP4 gene About this table
Genetic Association Database (GAD): NPHP4
Human Genome Epidemiology (HuGE) Navigator: NPHP4 (4 documents)
Export disorders for NPHP4 gene to outside databases
|
Publications
for NPHP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPHP4 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with NPHP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutational analysis of the NPHP4 gene in 250 patients with nephronophthisis. (PubMed id 15776426)1, 2, 4, 9 Hoefele J....Hildebrandt F. (2005)
- A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution. (PubMed id 12205563)1, 2, 3, 9 Otto E.... Hildebrandt F. (2002)
- The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin. (PubMed id 12244321)1, 2, 9 Mollet G....Saunier S. (2002)
- Mapping of gene loci for nephronophthisis type 4 and Senior-Loken syndrome, to chromosome 1p36. (PubMed id 11920287)1, 3 Schuermann M.J....Hildebrandt F. (2002)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes. (PubMed id 15661758)1, 9 Mollet G....Saunier S. (2005)
- Novel mutations in NPHP4 in a consanguineous family with histological findings of focal segmental glomerulosclerosis. (PubMed id 17954299)1, 9 Mistry K....Pollak M.R. (2007)
- Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome. (PubMed id 17558407)2, 9 Arts H.H.... Roepman R. (2007)
- Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. (PubMed id 16339905)1, 9 Roepman R....Cremers F.P. (2005)
- Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. (PubMed id 18076122)1, 9 Otto E.A....Hildebrandt F. (2008)
|
External Searches for NPHP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPHP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPHP4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NPHP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPHP4 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NPHP4 |
|
| | |
About This Section
| Patent Information for NPHP4 gene:
Search GeneIP for patents involving NPHP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPHP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPHP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPHP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPHP4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPHP4 | | OriGene 3'-UTR Clone for NPHP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPHP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPHP4 | | OriGene Custom Protein Services for NPHP4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPHP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPHP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPHP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPHP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPHP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPHP4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NPHP4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NPHP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPHP4 |
|  |  |  | | | | Search ThermoFisher Antibodies for NPHP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPHP4 |
|
|
|
|
