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NPFFR2 Gene

protein-coding   GIFtS: 61
GCID: GC04P072897

Neuropeptide FF Receptor 2

(Previous name: G protein-coupled receptor 74)
(Previous symbol: GPR74)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide FF Receptor 21 2     Neuropeptide FF 21 2
GPR741 2 3 5     Neuropeptide G-Protein Coupled Receptor2 3
NPFF22 3 5     G-Protein Coupled Receptor 742 3
NPGPR2 3 5     G-Protein Coupled Receptor HLWAR772 3
G Protein-Coupled Receptor 741 2     HLWAR772

External Ids:    HGNC: 45251   Entrez Gene: 108862   Ensembl: ENSG000000562917   OMIM: 6074495   UniProtKB: Q9Y5X53   

Export aliases for NPFFR2 gene to outside databases

Previous GC identifers: GC04P073116 GC04P068702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPFFR2 Gene:
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated
by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of
the opioid system. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2009)

GeneCards Summary for NPFFR2 Gene:
NPFFR2 (neuropeptide FF receptor 2) is a protein-coding gene. Diseases associated with NPFFR2 include neuroblastoma, and alzheimer's disease. GO annotations related to this gene include G-protein coupled receptor activity and opioid receptor binding. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPFF2_HUMAN, Q9Y5X5
Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating
peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This
receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second
messenger system

summary for NPFFR2 Gene:
Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein coupled receptors that are divided into two
subtypes; NPFF1 and NPFF2. NPFF receptors act through inhibition of adenylyl cyclase and activation of
phospholipase C and are coupled to voltage-gated N-type calcium channels. NPFF receptors have been
implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception through
modulation of the opioid system. NPFF receptors are distributed across the central nervous system, but each
subtype has specific localizations. NPFF1 are found in their highest concentrations in the septum, nucleus
of the tractus solitarius and hypothalamus, suggesting their participation in neuroendocrine functions.
NPFF2 are found in their highest concentrations in the diencephalon and superficial layers of the spinal
cord, suggesting their participation in the modulation of pain. The human genes encoding NPFF1 and NPFF2
receptors are located on chromosomes 4q21 and 10q21-22 respectively.

Gene Wiki entry for NPFFR2 (Neuropeptide FF receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPFFR2 gene promoter:
         AREB6   AML1a   FOXO3a   FOXO3   Cart-1   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPFFR2 promoter sequence
   Search Chromatin IP Primers for NPFFR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPFFR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21

NPFFR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPFFR2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P072897:  view genomic region     (about GC identifiers)

Start:
72,897,521 bp from pter      End:
73,013,918 bp from pter
Size:
116,398 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPFF2_HUMAN, Q9Y5X5 (See protein sequence)
Recommended Name: Neuropeptide FF receptor 2  
Size: 522 amino acids; 60270 Da
Sequence caution: Sequence=AAK58513.1; Type=Frameshift; Positions=503;
Secondary accessions: Q96RV1 Q9NR49
Alternative splicing: 4 isoforms:  Q9Y5X5-1   Q9Y5X5-2   Q9Y5X5-3   Q9Y5X5-4   

Explore the universe of human proteins at neXtProt for NPFFR2: NX_Q9Y5X5

Explore proteomics data for NPFFR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn110, Asn122, Asn133, Asn300

  • See NPFFR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138228.1  NP_004876.2  NP_444264.1  

    ENSEMBL proteins: 
     ENSP00000307822   ENSP00000340789   ENSP00000379321   ENSP00000351599  
    Reactome Protein details: Q9Y5X5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RFAPR: GPCR / Class A : RF amide peptide receptors
    NPFFR: GPCR / Class A : Neuropeptide receptors : FF/AF

    IUPHAR Guide to PHARMACOLOGY protein family classification: NPFF2 receptor
    Neuropeptide FF/neuropeptide AF receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005397 NPFF_rcpt_2
     IPR005395 NPFF_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y5X5

    ProtoNet protein and cluster: Q9Y5X5

    2 Blocks protein domains:
    IPB005395 Neuropeptide FF receptor family signature
    IPB005397 Type 2 neuropeptide FF receptor signature


    UniProtKB/Swiss-Prot: NPFF2_HUMAN, Q9Y5X5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NPFFR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPFF2_HUMAN, Q9Y5X5
    Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating
    peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This
    receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second
    messenger system

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10851242
    GO:0008188neuropeptide receptor activity IEA--
    GO:0031628opioid receptor binding IEA--
         
    NPFFR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NPFFR2:
     Decreased viability of wild-ty  High actin ratio cells 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPFF2_HUMAN, Q9Y5X5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10079187
    GO:0015629actin cytoskeleton IDA--
    GO:0016021integral component of membrane ----

    NPFFR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPFFR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Orexin and neuropeptides FF and QRFP bind to their respective receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NPFFR2
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for NPFFR2
        Orexin and neuropeptides FF and QRFP bind to their respective receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for NPFFR2):
        Neuroactive ligand-receptor interaction


    NPFFR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPFFR2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPFFR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPFFR2 (Q9Y5X53 ENSP000003078224) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPFFO151303, ENSP000002670174I2D: score=1 STRING: ENSP00000267017
    NPYP013033, ENSP000002421524I2D: score=1 STRING: ENSP00000242152
    HCRTO436123, ENSP000002933304I2D: score=1 STRING: ENSP00000293330
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS10079187
    GO:0009582detection of abiotic stimulus TAS10851242
    GO:0043408regulation of MAPK cascade IEA--
    GO:0045761regulation of adenylate cyclase activity IEA--
    GO:2000479regulation of cAMP-dependent protein kinase activity IEA--

    NPFFR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for NPFFR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist[230960-31-3]
    RFRP 3 (human)NPFF1 agonist; GnIH homolog[311309-27-0]
    RF 9Selective NPFF1 and NPFF2 antagonist[876310-60-0]

    1 HMDB Compound for NPFFR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for NPFFR2 (NPFF2 receptor) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    dNPA
    AgonistFull agonist10.615680260 16129413
    [125I]EYF
    AgonistFull agonist10.212242085
    neuropeptide FF
    AgonistFull agonist9.712421602 11325787
    1DMe
    AgonistFull agonist8.5 - 9.712421602 11024015 12242085
    EFWSLAAPQRF-NH2
    AgonistFull agonist9.612242085
    [3H]EYF
    AgonistFull agonist9.319682524
    pancreatic polypeptide
    AgonistFull agonist8.1 - 8.211325787 11024015
    Y-RFRP-3
    AgonistFull agonist812421602 12242085
    RFRP-3
    AgonistFull agonist7.812421602 12242085
    RF9
    AntagonistAntagonist7.116407169

    2 Novoseek inferred chemical compound relationships for NPFFR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    npff 96.1 13 12609745 (4), 12242085 (1), 19922753 (1), 15127947 (1) (see all 6)
    bibp3226 88 1 15127947 (1)



    NPFFR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPFFR2 gene (3 alternative transcripts): 
    NM_001144756.1  NM_004885.2  NM_053036.2  

    Unigene Cluster for NPFFR2:

    Neuropeptide FF receptor 2
    Hs.99231  [show with all ESTs]
    Unigene Representative Sequence: NM_004885
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308744(uc003hgg.2 uc010iig.2) ENST00000344413 ENST00000395999(uc003hgi.2 uc003hgh.2)
    ENST00000358749 ENST00000506359
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    Additional mRNA sequence: 

    AF119815.1 AF236083.1 AF257210.1 AF268899.1 AF330053.1 AJ311393.1 AK290937.1 AK308069.1 
    BC101636.1 BC113713.1 

    6 DOTS entries:

    DT.95263537  DT.100688119  DT.40119660  DT.95263535  DT.100739464  DT.97763577 

    Selected AceView cDNA sequences (see all 27):

    AF257210 CR592672 NM_053036 CF529515 AF268899 CF529755 BX283068 BX380900 
    BX280001 AF330053 CF529766 AA449920 AJ311393 AA449919 CA429142 AF119815 
    BX327238 AF236083 CB997199 BU194892 BM989177 NM_004885 CB997680 BG218742 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                 -                     
    SP2:              -     -                 -                     
    SP3:                                      -                     
    SP4:              -     -     -           -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for NPFFR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPFFR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAACCTT
    NPFFR2 Expression
    About this image

    NPFFR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPFFR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99231

    UniProtKB/Swiss-Prot: NPFF2_HUMAN, Q9Y5X5
    Tissue specificity: Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small
    intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon,
    kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is
    highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous
    tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower
    levels, in kidney, liver, lung and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NPFFR2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPFFR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npffr21 , 5 neuropeptide FF receptor 21, 5 82.25(n)1
    79.76(a)1
      5 (44.32 cM)5
    1044431  NM_133192.31  NP_573455.21 
     895274295 
    chicken
    (Gallus gallus)
    Aves NPFFR21 neuropeptide FF receptor 2 68.61(n)
    67.4(a)
      428759  NM_001034825.2  NP_001029997.2 
    lizard
    (Anolis carolinensis)
    Reptilia NPFFR26
    neuropeptide FF receptor 2
    61(a)
    1 ↔ 1
    5(147749957-147808953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193252 Xenopus laevis transcribed sequence with moderate similarity more 73.8(n)    BQ384810.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npffr2.11 neuropeptide FF receptor 2.1 64.95(n)
    65.2(a)
      560955  NM_001105109.1  NP_001098579.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SIFR1 SIFamide receptor 48.15(n)
    35(a)
      42530  NM_001170203.1  NP_001163674.1 


    ENSEMBL Gene Tree for NPFFR2 (if available)
    TreeFam Gene Tree for NPFFR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPFFR2 gene
    GPR832  HCRTR22  PRLHR2  NPY5R2  NPY4R2  TACR12  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    13 SIMAP similar genes for NPFFR2 using alignment to 2 protein entries:     NPFF2_HUMAN (see all proteins):
    NPFFR1    NPY2R    GPR83    PRLHR    hA2aR    QRFPR
    NPY6R    SSTR2    NPY1R    NPY4R    PPYR1    HCRTR1
    HCRTR2

    NPFFR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPFFR2 (see all 2771)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820092981,2
    C--72895535(+) GTAGCC/TAGAGA 1 -- us2k10--------
    rs798667521,2
    C,F--72895603(+) AACTGT/ATGCAG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs609945921,2
    --72895756(+) GTGGAC/TGGGAA 1 -- us2k10--------
    rs1415142101,2
    --72895784(+) ACAGAC/TTGGGC 1 -- us2k10--------
    rs1470395601,2
    --72895884(+) TGTTTC/TAAATG 1 -- us2k10--------
    rs1141127331,2
    C,F--72896015(+) TAGACA/GTGGGC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1448513171,2
    C--72896079(+) GAATG-/ATGA  
            
    ATGAA
    1 -- us2k10--------
    rs133402841,2
    C,F,H--72896193(+) CTTATG/TGATAT 1 -- us2k15Minor allele frequency- T:0.01NS EA WA 514
    rs64467951,2
    C,F,A,H--72896212(+) GTTTTC/TAGTGG 1 -- us2k127Minor allele frequency- T:0.45NA EA NS WA CSA 2596
    rs791932031,2
    F--72896293(+) AATCAT/CAGTTT 1 -- us2k12Minor allele frequency- C:0.02CSA WA 120

    HapMap Linkage Disequilibrium report for NPFFR2 (72897521 - 73013918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NPFFR2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2289844CNV Deletion18987734
    esv2663080CNV Deletion23128226
    esv269457CNV Insertion20981092
    esv270098CNV Insertion20981092
    esv273932CNV Insertion20981092
    nsv508287CNV Loss20534489
    nsv518185CNV Loss19592680
    esv22388CNV Loss19812545
    nsv879480CNV Loss21882294
    nsv879477CNV Gain21882294

    Human Gene Mutation Database (HGMD): NPFFR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPFFR2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPFFR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607449    OMIM disorders: --

    6 diseases for NPFFR2:    
    About MalaCards
    neuroblastoma    alzheimer's disease    lung cancer    pancreatitis
    prostatitis    malaria


    NPFFR2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NPFFR2
    Human Genome Epidemiology (HuGE) Navigator: NPFFR2 (1 document)

    Export disorders for NPFFR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPFFR2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with NPFFR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. (PubMed id 10851242)1, 2, 3 Elshourbagy N.A....Sarau H.M. (J. Biol. Chem. 2000)
    2. Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta. (PubMed id 10079187)1, 2, 3 Cikos S.... Koppel J. (Biochem. Biophys. Res. Commun. 1999)
    3. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PubMed id 11024015)1, 2, 9 Bonini J.A....Borowsky B. (J. Biol. Chem. 2000)
    4. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. (PubMed id 17503329)1, 4 Dahlman I....Arner P. (Am. J. Hum. Genet. 2007)
    5. Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family. (PubMed id 10837915)1, 2 Parker R.M.C.... Herzog H. (Brain Res. Mol. Brain Res. 2000)
    6. Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus. (PubMed id 12609745)1, 9 Laemmle B....Wieland H.A. (Regul. Pept. 2003)
    7. Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors. (PubMed id 15127947)1, 9 EngstrAPm M....Panula P. (Peptides 2003)
    8. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. (PubMed id 12606605)1, 9 EngstrAPm M....Panula P. (J. Pharmacol. Exp. Ther. 2003)
    9. GRK2 protein-mediated transphosphorylation contributes to loss of function of I1-opioid receptors induced by neuropeptide FF (NPFF2) receptors. (PubMed id 22375000)1 MoulAcdous L....Mollereau C. (J. Biol. Chem. 2012)
    10. Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. (PubMed id 21818152)1 Hunt S.C....Adams T.D. (Obesity (Silver Spring) 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10886 HGNC: 4525 AceView: GPR74 Ensembl:ENSG00000056291 euGenes: HUgn10886
    ECgene: NPFFR2 Kegg: 10886 H-InvDB: NPFFR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPFFR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPFFR2 gene:
    Search GeneIP for patents involving NPFFR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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