Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NPFFR2 Gene

Aliases for NPFFR2 Gene

  • Neuropeptide FF Receptor 2 2 3 5
  • Neuropeptide G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor HLWAR77 3 4
  • G-Protein Coupled Receptor 74 3 4
  • Neuropeptide FF 2 2 3
  • GPR74 3 4
  • NPFF2 3 4
  • NPGPR 3 4
  • G Protein-Coupled Receptor 74 2
  • HLWAR77 3

External Ids for NPFFR2 Gene

Previous HGNC Symbols for NPFFR2 Gene

  • GPR74

Previous GeneCards Identifiers for NPFFR2 Gene

  • GC04P073116
  • GC04P072897
  • GC04P068702

Summaries for NPFFR2 Gene

Entrez Gene Summary for NPFFR2 Gene

  • This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for NPFFR2 Gene

NPFFR2 (Neuropeptide FF Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for NPFFR2 Gene

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NPFFR2 Gene

  • Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.

Gene Wiki entry for NPFFR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPFFR2 Gene

Genomics for NPFFR2 Gene

Regulatory Elements for NPFFR2 Gene

Enhancers for NPFFR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NPFFR2 on UCSC Golden Path with GeneCards custom track

Promoters for NPFFR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NPFFR2 Gene

Chromosome:
4
Start:
72,031,804 bp from pter
End:
72,148,201 bp from pter
Size:
116,398 bases
Orientation:
Plus strand

Genomic View for NPFFR2 Gene

Genes around NPFFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPFFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPFFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFFR2 Gene

Proteins for NPFFR2 Gene

  • Protein details for NPFFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X5-NPFF2_HUMAN
    Recommended name:
    Neuropeptide FF receptor 2
    Protein Accession:
    Q9Y5X5
    Secondary Accessions:
    • Q96RV1
    • Q9NR49

    Protein attributes for NPFFR2 Gene

    Size:
    522 amino acids
    Molecular mass:
    60270 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK58513.1; Type=Frameshift; Positions=503; Evidence={ECO:0000305};

    Alternative splice isoforms for NPFFR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPFFR2 Gene

Post-translational modifications for NPFFR2 Gene

  • Glycosylation at Asn 110, Asn 122, Asn 133, and Asn 300
  • Modification sites at PhosphoSitePlus

Other Protein References for NPFFR2 Gene

No data available for DME Specific Peptides for NPFFR2 Gene

Domains & Families for NPFFR2 Gene

Gene Families for NPFFR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5X5

UniProtKB/Swiss-Prot:

NPFF2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPFFR2: view

Function for NPFFR2 Gene

Molecular function for NPFFR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for NPFFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10851242
GO:0008188 neuropeptide receptor activity IBA --
GO:0031628 opioid receptor binding IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with NPFFR2: view

Phenotypes for NPFFR2 Gene

genes like me logo Genes that share phenotypes with NPFFR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NPFFR2

CRISPR Products

miRNA for NPFFR2 Gene

miRTarBase miRNAs that target NPFFR2

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NPFFR2 Gene

Localization for NPFFR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFFR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPFFR2 Gene COMPARTMENTS Subcellular localization image for NPFFR2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NPFFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10079187
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NPFFR2: view

Pathways & Interactions for NPFFR2 Gene

genes like me logo Genes that share pathways with NPFFR2: view

SIGNOR curated interactions for NPFFR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPFFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10079187
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 chemical synaptic transmission IBA --
GO:0009582 detection of abiotic stimulus TAS 10851242
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with NPFFR2: view

Drugs & Compounds for NPFFR2 Gene

(20) Drugs for NPFFR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide FF Pharma Full agonist, Agonist 0
BIBP3226 Pharma Antagonist 0
RF 9 Pharma neuropeptide FF receptors antagonist, Selective NPFF1 and NPFF2 antagonist 0
RFRP 3 (human) Pharma NPFF1 agonist; GnIH homolog 0
[<sup>125</sup>I]EYF Pharma Full agonist, Agonist 0

(2) Additional Compounds for NPFFR2 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
RFRP-1 (human)
311309-25-8

(3) Tocris Compounds for NPFFR2 Gene

Compound Action Cas Number
RF 9 Selective NPFF1 and NPFF2 antagonist 876310-60-0
RFRP 3 (human) NPFF1 agonist; GnIH homolog 311309-27-0
RFRP-1 (human) Potent NPFF receptor agonist 311309-25-8

(7) ApexBio Compounds for NPFFR2 Gene

Compound Action Cas Number
BIBP 3226 trifluoroacetate Mixed NPY1-R and NPFF receptor inhibitor 1068148-47-9
Neuropeptide AF (human) 192387-38-5
Neuropeptide FF 99566-27-5
Neuropeptide SF (human) 192387-39-6
Neuropeptide SF (mouse, rat) 230960-31-3
RF 9 neuropeptide FF receptors antagonist 876310-60-0
RFRP 3 (human) 311309-27-0
genes like me logo Genes that share compounds with NPFFR2: view

Transcripts for NPFFR2 Gene

Unigene Clusters for NPFFR2 Gene

Neuropeptide FF receptor 2:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for NPFFR2 Gene

GeneLoc Exon Structure for
NPFFR2
ECgene alternative splicing isoforms for
NPFFR2

Expression for NPFFR2 Gene

mRNA expression in normal human tissues for NPFFR2 Gene

mRNA differential expression in normal tissues according to GTEx for NPFFR2 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.5) and Brain - Anterior cingulate cortex (BA24) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of NPFFR2 Gene:

NPFFR2

SOURCE GeneReport for Unigene cluster for NPFFR2 Gene:

Hs.99231

mRNA Expression by UniProt/SwissProt for NPFFR2 Gene:

Q9Y5X5-NPFF2_HUMAN
Tissue specificity: Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.
genes like me logo Genes that share expression patterns with NPFFR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPFFR2 Gene

Orthologs for NPFFR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPFFR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPFFR2 34
  • 87.99 (n)
  • 86.26 (a)
NPFFR2 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPFFR2 34
  • 86.26 (n)
  • 81.62 (a)
NPFFR2 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npffr2 34
  • 82.25 (n)
  • 79.76 (a)
Npffr2 16
Npffr2 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPFFR2 34
  • 99.23 (n)
  • 98.66 (a)
NPFFR2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npffr2 34
  • 81.57 (n)
  • 78.37 (a)
oppossum
(Monodelphis domestica)
Mammalia NPFFR2 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPFFR2 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPFFR2 34
  • 68.61 (n)
  • 67.4 (a)
NPFFR2 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPFFR2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npffr2 34
  • 65.54 (n)
  • 65.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19325 34
zebrafish
(Danio rerio)
Actinopterygii npffr2.1 34
  • 64.95 (n)
  • 65.2 (a)
NPFFR2.1 35
  • 61 (a)
OneToMany
npffr2.2 35
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA7 34
  • 46.44 (n)
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIFR 34
  • 48.15 (n)
  • 35 (a)
SIFR 35
  • 18 (a)
OneToMany
Species where no ortholog for NPFFR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPFFR2 Gene

ENSEMBL:
Gene Tree for NPFFR2 (if available)
TreeFam:
Gene Tree for NPFFR2 (if available)

Paralogs for NPFFR2 Gene

(13) SIMAP similar genes for NPFFR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NPFFR2: view

Variants for NPFFR2 Gene

Sequence variations from dbSNP and Humsavar for NPFFR2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs983345 -- 72,148,081(-) AAGTT(G/T)GGAAA downstream-variant-500B, utr-variant-3-prime
rs993280 -- 72,145,149(-) GATGA(A/G)TAAGA intron-variant
rs2102651 -- 72,132,313(+) gttcc(A/G)tcaaa intron-variant
rs2203304 -- 72,140,596(-) ccctg(G/T)gatgc intron-variant
rs3062262 -- 72,131,973(+) GATAA(-/AAA)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPFFR2 Gene

Variant ID Type Subtype PubMed ID
dgv9128n54 CNV loss 21841781
esv22388 CNV loss 19812545
esv2289844 CNV deletion 18987734
esv2663080 CNV deletion 23128226
esv3305821 CNV mobile element insertion 20981092
esv3393306 CNV insertion 20981092
esv3569516 CNV loss 25503493
nsv1114546 CNV deletion 24896259
nsv1119008 CNV deletion 24896259
nsv508287 CNV deletion 20534489
nsv518185 CNV loss 19592680
nsv829968 CNV gain 17160897

Variation tolerance for NPFFR2 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPFFR2 Gene

Human Gene Mutation Database (HGMD)
NPFFR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPFFR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFFR2 Gene

Disorders for NPFFR2 Gene

Relevant External Links for NPFFR2

Genetic Association Database (GAD)
NPFFR2
Human Genome Epidemiology (HuGE) Navigator
NPFFR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPFFR2

No disorders were found for NPFFR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPFFR2 Gene

Publications for NPFFR2 Gene

  1. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. (PMID: 10851242) Elshourbagy N.A. … Sarau H.M. (J. Biol. Chem. 2000) 2 3 4 65
  2. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PMID: 11024015) Bonini J.A. … Borowsky B. (J. Biol. Chem. 2000) 3 4 22 65
  3. Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta. (PMID: 10079187) Cikos S. … Koppel J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 65
  4. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. (PMID: 17503329) Dahlman I. … Arner P. (Am. J. Hum. Genet. 2007) 3 46 65
  5. Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors. (PMID: 12606605) EngstrAPm M. … Panula P. (J. Pharmacol. Exp. Ther. 2003) 3 22 65

Products for NPFFR2 Gene

Sources for NPFFR2 Gene

Content
Loading form....