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Aliases for NPFFR1 Gene

Aliases for NPFFR1 Gene

  • Neuropeptide FF Receptor 1 2 3 5
  • RFamide-Related Peptide Receptor OT7T022 3 4
  • G-Protein Coupled Receptor 147 3 4
  • Neuropeptide FF 1 2 3
  • GPR147 3 4
  • NPFF1 3 4
  • G Protein-Coupled Receptor 147 2
  • NPFF1R1 3
  • OT7T022 3

External Ids for NPFFR1 Gene

Previous HGNC Symbols for NPFFR1 Gene

  • GPR147

Previous GeneCards Identifiers for NPFFR1 Gene

  • GC10M071685
  • GC10M072014
  • GC10M066007

Summaries for NPFFR1 Gene

GeneCards Summary for NPFFR1 Gene

NPFFR1 (Neuropeptide FF Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPFFR2.

UniProtKB/Swiss-Prot for NPFFR1 Gene

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NPFFR1 Gene

  • Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.

Gene Wiki entry for NPFFR1 Gene

Additional gene information for NPFFR1 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPFFR1 Gene

Genomics for NPFFR1 Gene

GeneHancer (GH) Regulatory Elements for NPFFR1 Gene

Promoters and enhancers for NPFFR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I070231 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 11.1 +50.0 49963 4.1 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PPA1 AIFM2 SAR1A NPFFR1 GC10M070217
GH10I070322 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -40.9 -40897 4.1 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 RXRA SP5 ZHX2 MXD4 PPA1 NPFFR1 NODAL LRRC20
GH10I070575 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 -294.5 -294452 5.2 HDGF PKNOX1 SMAD1 FEZF1 YBX1 IRF4 ZNF766 CBX5 ZNF213 ZNF207 ADAMTS14 PRF1 NPFFR1 PCBD1 YY1P1
GH10I070331 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.3 -48.2 -48156 1.5 PKNOX1 ATF1 SMAD1 ARNT ZNF48 NCOA2 ZNF766 E2F8 FOS ATF7 NPFFR1 PPA1 CALM2P2 SAR1A TYSND1 LRRC20
GH10I070089 Enhancer 1.1 Ensembl ENCODE 15.5 +191.7 191718 4.1 MLX ARID4B DMAP1 RAD21 THRB RARA ETS1 TCF12 CREM THAP11 NPFFR1 TYSND1 CALM2P2 SAR1A LRRC20 PIR45222 H2AFY2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPFFR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPFFR1 gene promoter:

Genomic Locations for NPFFR1 Gene

Genomic Locations for NPFFR1 Gene
chr10:70,247,329-70,283,694
(GRCh38/hg38)
Size:
36,366 bases
Orientation:
Minus strand
chr10:72,007,085-72,043,450
(GRCh37/hg19)

Genomic View for NPFFR1 Gene

Genes around NPFFR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPFFR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPFFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFFR1 Gene

Proteins for NPFFR1 Gene

  • Protein details for NPFFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ6-NPFF1_HUMAN
    Recommended name:
    Neuropeptide FF receptor 1
    Protein Accession:
    Q9GZQ6
    Secondary Accessions:
    • A2RRF0
    • Q8NGR0
    • Q96RN3

    Protein attributes for NPFFR1 Gene

    Size:
    430 amino acids
    Molecular mass:
    47819 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPFFR1 Gene

Post-translational modifications for NPFFR1 Gene

  • Glycosylation at isoforms=10, Asn18, isoforms=29, Asn113, and Asn195

Other Protein References for NPFFR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPFFR1 Gene

Domains & Families for NPFFR1 Gene

Gene Families for NPFFR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NPFFR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZQ6

UniProtKB/Swiss-Prot:

NPFF1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPFFR1: view

Function for NPFFR1 Gene

Molecular function for NPFFR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for NPFFR1 Gene

Gene Ontology (GO) - Molecular Function for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA,NAS 11024015
GO:0008188 neuropeptide receptor activity NAS 11024015
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with NPFFR1: view
genes like me logo Genes that share phenotypes with NPFFR1: view

Animal Models for NPFFR1 Gene

MGI Knock Outs for NPFFR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for NPFFR1 (Neuropeptide FF R1/NPFFR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPFFR1 Gene

Localization for NPFFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFFR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPFFR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPFFR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPFFR1 Gene

Pathways & Interactions for NPFFR1 Gene

genes like me logo Genes that share pathways with NPFFR1: view

SIGNOR curated interactions for NPFFR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with NPFFR1: view

Drugs & Compounds for NPFFR1 Gene

(21) Drugs for NPFFR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Pancreatic Polypeptide Investigational Pharma Partial agonist, Agonist 21
neuropeptide FF Pharma Full agonist, Agonist 0
BIBP3226 Pharma Antagonist 0
Neuropeptide SF (mouse, rat) Pharma NPFF1 and NPFF2 agonist 0

(2) Additional Compounds for NPFFR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for NPFFR1 Gene

Compound Action Cas Number
Neuropeptide AF (human) Implicated in pain modulation, opioid function and metabolism 192387-38-5
Neuropeptide FF Endogenous NPFF1 and NPFF2 agonist 99566-27-5
Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist 230960-31-3

(7) ApexBio Compounds for NPFFR1 Gene

Compound Action Cas Number
BIBP 3226 trifluoroacetate Mixed NPY1-R and NPFF receptor inhibitor 1068148-47-9
Neuropeptide AF (human) 192387-38-5
Neuropeptide FF 99566-27-5
Neuropeptide SF (human) 192387-39-6
Neuropeptide SF (mouse, rat) 230960-31-3
RF 9 neuropeptide FF receptors antagonist 876310-60-0
RFRP 3 (human) 311309-27-0
genes like me logo Genes that share compounds with NPFFR1: view

Drug Products

Transcripts for NPFFR1 Gene

mRNA/cDNA for NPFFR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPFFR1 Gene

Neuropeptide FF receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for NPFFR1 (Neuropeptide FF R1/NPFFR1)

Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR1 Gene

No ASD Table

Relevant External Links for NPFFR1 Gene

GeneLoc Exon Structure for
NPFFR1
ECgene alternative splicing isoforms for
NPFFR1

Expression for NPFFR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPFFR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPFFR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.8), Brain - Cerebellum (x7.8), and Nerve - Tibial (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of NPFFR1 Gene:

NPFFR1

SOURCE GeneReport for Unigene cluster for NPFFR1 Gene:

Hs.302026

Evidence on tissue expression from TISSUES for NPFFR1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NPFFR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPFFR1 Gene

Orthologs for NPFFR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPFFR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPFFR1 33 34
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia NPFFR1 33 34
  • 89.67 (n)
dog
(Canis familiaris)
Mammalia NPFFR1 33
  • 89.2 (n)
mouse
(Mus musculus)
Mammalia Npffr1 33 16 34
  • 86.12 (n)
rat
(Rattus norvegicus)
Mammalia Npffr1 33
  • 86.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NPFFR1 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPFFR1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPFFR1 33
  • 75.77 (n)
NPFF1 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPFFR1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npffr1 33
  • 65.8 (n)
zebrafish
(Danio rerio)
Actinopterygii npffr1l3 33
  • 68.04 (n)
NPFFR1 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SIFR 34
  • 16 (a)
OneToMany
Species where no ortholog for NPFFR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPFFR1 Gene

ENSEMBL:
Gene Tree for NPFFR1 (if available)
TreeFam:
Gene Tree for NPFFR1 (if available)

Paralogs for NPFFR1 Gene

Paralogs for NPFFR1 Gene

(8) SIMAP similar genes for NPFFR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPFFR1: view

Variants for NPFFR1 Gene

Sequence variations from dbSNP and Humsavar for NPFFR1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000019110 -- 70,277,478(-) T/A intron_variant
rs1000065365 -- 70,280,815(-) A/G intron_variant
rs1000094295 -- 70,270,637(-) C/T intron_variant
rs1000145994 -- 70,266,633(-) C/A intron_variant
rs1000178556 -- 70,254,739(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPFFR1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
esv3578973 CNV loss 25503493
nsv1041698 CNV gain 25217958
nsv831908 CNV gain 17160897

Variation tolerance for NPFFR1 Gene

Gene Damage Index Score: 7.40; 81.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPFFR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPFFR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFFR1 Gene

Disorders for NPFFR1 Gene

Additional Disease Information for NPFFR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NPFFR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPFFR1 Gene

Publications for NPFFR1 Gene

  1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PMID: 11024015) Bonini JA … Borowsky B (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PMID: 11025660) Hinuma S … Fujino M (Nature cell biology 2000) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103. (PMID: 26211894) Rouméas L … Bihel F (Peptides 2015) 3 58

Products for NPFFR1 Gene

Sources for NPFFR1 Gene

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