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Aliases for NPFFR1 Gene

Aliases for NPFFR1 Gene

  • Neuropeptide FF Receptor 1 2 3
  • NPFF1 3 4 6
  • RFamide-Related Peptide Receptor OT7T022 3 4
  • G Protein-Coupled Receptor 147 2 3
  • G-Protein Coupled Receptor 147 3 4
  • Neuropeptide FF 1 2 3
  • GPR147 3 4
  • NPFF1R1 3
  • OT7T022 3

External Ids for NPFFR1 Gene

Previous Symbols for NPFFR1 Gene

  • GPR147

Summaries for NPFFR1 Gene

GeneCards Summary for NPFFR1 Gene

NPFFR1 (Neuropeptide FF Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for NPFFR1 Gene

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for NPFFR1 Gene

  • Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors act through inhibition of adenylyl cyclase and activation of phospholipase C and are coupled to voltage-gated N-type calcium channels. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception through modulation of the opioid system. NPFF receptors are distributed across the central nervous system, but each subtype has specific localizations. NPFF1 are found in their highest concentrations in the septum, nucleus of the tractus solitarius and hypothalamus, suggesting their participation in neuroendocrine functions. NPFF2 are found in their highest concentrations in the diencephalon and superficial layers of the spinal cord, suggesting their participation in the modulation of pain. The human genes encoding NPFF1 and NPFF2 receptors are located on chromosomes 4q21 and 10q21-22 respectively.

Gene Wiki entry for NPFFR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPFFR1 Gene

Genomics for NPFFR1 Gene

Genomic Location for NPFFR1 Gene

Start:
70,247,329 bp from pter
End:
70,283,694 bp from pter
Size:
36,366 bases
Orientation:
Minus strand

Genomic View for NPFFR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPFFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFFR1 Gene

Regulatory Elements for NPFFR1 Gene

Proteins for NPFFR1 Gene

  • Protein details for NPFFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ6-NPFF1_HUMAN
    Recommended name:
    Neuropeptide FF receptor 1
    Protein Accession:
    Q9GZQ6
    Secondary Accessions:
    • A2RRF0
    • Q8NGR0
    • Q96RN3

    Protein attributes for NPFFR1 Gene

    Size:
    430 amino acids
    Molecular mass:
    47819 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPFFR1 Gene

Proteomics data for NPFFR1 Gene at MOPED

Post-translational modifications for NPFFR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn10, Asn18, Asn29, Asn113, and Asn195

Other Protein References for NPFFR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPFFR1 Gene

Domains for NPFFR1 Gene

Gene Families for NPFFR1 Gene

HGNC:
  • RFAPR :GPCR / Class A : RF amide peptide receptors
  • NPFFR :GPCR / Class A : Neuropeptide receptors : FF/AF
IUPHAR :

Suggested Antigen Peptide Sequences for NPFFR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZQ6

UniProtKB/Swiss-Prot:

NPFF1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9GZQ6
genes like me logo Genes that share domains with NPFFR1: view

Function for NPFFR1 Gene

Molecular function for NPFFR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 11024015
GO:0008188 neuropeptide receptor activity NAS 11024015
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with NPFFR1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPFFR1 Gene

Localization for NPFFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFFR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPFFR1 Gene COMPARTMENTS Subcellular localization image for NPFFR1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NPFFR1: view

Pathways for NPFFR1 Gene

genes like me logo Genes that share pathways with NPFFR1: view

Pathways by source for NPFFR1 Gene

Gene Ontology (GO) - Biological Process for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
GO:0008150 biological_process ND --
GO:0032870 cellular response to hormone stimulus IBA --
genes like me logo Genes that share ontologies with NPFFR1: view

Compounds for NPFFR1 Gene

(3) Tocris Compounds for NPFFR1 Gene

Compound Action Cas Number
Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist [230960-31-3]
RF 9 Selective NPFF1 and NPFF2 antagonist [876310-60-0]
RFRP 3 (human) NPFF1 agonist; GnIH homolog [311309-27-0]

(1) HMDB Compounds for NPFFR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(14) IUPHAR Ligand for NPFFR1 Gene

Ligand Type Action Affinity Pubmed IDs
neuropeptide FF Agonist Full agonist 9.9
[125I]Y-RFRP-3 Agonist Full agonist 9.7
Y-RFRP-3 Agonist Full agonist 9.4
RFRP-3 Agonist Full agonist 9.3
1DMe Agonist Full agonist 9
[125I]1DMe Agonist Full agonist 8.9
[3H]NPVF Agonist Full agonist 8.6
AC262970 Antagonist Antagonist 8.1
AC262620 Antagonist Antagonist 8.1
pancreatic polypeptide Agonist Full agonist 8
BIBP3226 Antagonist Antagonist 7.8
EFWSLAAPQRF-NH2 Agonist Full agonist 7.3
RF9 Antagonist Antagonist 7.2
[125I]NPFF Agonist Full agonist

(2) Novoseek inferred chemical compound relationships for NPFFR1 Gene

Compound -log(P) Hits PubMed IDs
npff 96 6
bibp3226 85.9 1
genes like me logo Genes that share compounds with NPFFR1: view

Transcripts for NPFFR1 Gene

mRNA/cDNA for NPFFR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPFFR1 Gene

Neuropeptide FF receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR1 Gene

No ASD Table

Relevant External Links for NPFFR1 Gene

GeneLoc Exon Structure for
NPFFR1
ECgene alternative splicing isoforms for
NPFFR1

Expression for NPFFR1 Gene

mRNA expression in normal human tissues for NPFFR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPFFR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.8), Brain - Cerebellum (7.8), and Nerve - Tibial (4.3).

SOURCE GeneReport for Unigene cluster for NPFFR1 Gene Hs.302026

genes like me logo Genes that share expressions with NPFFR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for NPFFR1 Gene

Orthologs for NPFFR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPFFR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPFFR1 35
  • 99.15 (n)
  • 98.6 (a)
NPFFR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NPFFR1 35
  • 89.67 (n)
  • 89.04 (a)
NPFFR1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPFFR1 35
  • 89.2 (n)
  • 88.42 (a)
mouse
(Mus musculus)
Mammalia Npffr1 35
  • 86.12 (n)
  • 86.98 (a)
Npffr1 16
Npffr1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPFFR1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPFFR1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npffr1 35
  • 86.12 (n)
  • 86.51 (a)
chicken
(Gallus gallus)
Aves NPFF1 36
  • 70 (a)
OneToOne
NPFFR1 35
  • 75.77 (n)
  • 74.48 (a)
lizard
(Anolis carolinensis)
Reptilia NPFFR1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npffr1 35
  • 65.8 (n)
  • 69.97 (a)
zebrafish
(Danio rerio)
Actinopterygii NPFFR1 36
  • 59 (a)
OneToOne
npffr1l3 35
  • 68.04 (n)
  • 65.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIFR 36
  • 16 (a)
OneToMany
Species with no ortholog for NPFFR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPFFR1 Gene

ENSEMBL:
Gene Tree for NPFFR1 (if available)
TreeFam:
Gene Tree for NPFFR1 (if available)

Paralogs for NPFFR1 Gene

Selected SIMAP similar genes for NPFFR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPFFR1: view

Variants for NPFFR1 Gene

Sequence variations from dbSNP and Humsavar for NPFFR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs713382 -- 70,278,270(+) TCTCA(C/T)AGTCA intron-variant
rs868075 -- 70,278,643(-) GGATA(C/T)TGGAG intron-variant
rs869812 -- 70,278,000(+) ATTAT(A/C)TTTTC intron-variant
rs883166 -- 70,283,274(-) GGGGT(G/T)CCTCT intron-variant
rs958448 -- 70,279,079(+) TCCAT(C/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPFFR1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831908 CNV Gain 17160897

Relevant External Links for NPFFR1 Gene

HapMap Linkage Disequilibrium report
NPFFR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFFR1 Gene

Disorders for NPFFR1 Gene

Relevant External Links for NPFFR1

Genetic Association Database (GAD)
NPFFR1
Human Genome Epidemiology (HuGE) Navigator
NPFFR1
genes like me logo Genes that share disorders with NPFFR1: view

No data available for UniProtKB/Swiss-Prot for NPFFR1 Gene

Publications for NPFFR1 Gene

  1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PMID: 11024015) Bonini J.A. … Borowsky B. (J. Biol. Chem. 2000) 2 3 4 23
  2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PMID: 11025660) Hinuma S. … Fujino M. (Nat. Cell Biol. 2000) 3 4 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PMID: 16754659) Dowal L. … Scarlata S. (J. Biol. Chem. 2006) 3

Products for NPFFR1 Gene

  • antibodies-online peptides for NPFFR1
  • antibodies-online antibodies for NPFFR1
  • antibodies-online kits for NPFFR1

Sources for NPFFR1 Gene

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