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Aliases for NPFFR1 Gene

Aliases for NPFFR1 Gene

  • Neuropeptide FF Receptor 1 2 3 5
  • RFamide-Related Peptide Receptor OT7T022 3 4
  • G Protein-Coupled Receptor 147 2 3
  • G-Protein Coupled Receptor 147 3 4
  • Neuropeptide FF 1 2 3
  • GPR147 3 4
  • NPFF1 3 4
  • NPFF1R1 3
  • OT7T022 3

External Ids for NPFFR1 Gene

Previous HGNC Symbols for NPFFR1 Gene

  • GPR147

Previous GeneCards Identifiers for NPFFR1 Gene

  • GC10M071685
  • GC10M072014
  • GC10M066007

Summaries for NPFFR1 Gene

GeneCards Summary for NPFFR1 Gene

NPFFR1 (Neuropeptide FF Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for NPFFR1 Gene

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NPFFR1 Gene

  • Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.

Gene Wiki entry for NPFFR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPFFR1 Gene

Genomics for NPFFR1 Gene

Regulatory Elements for NPFFR1 Gene

Genomic Location for NPFFR1 Gene

Chromosome:
10
Start:
70,247,329 bp from pter
End:
70,283,694 bp from pter
Size:
36,366 bases
Orientation:
Minus strand

Genomic View for NPFFR1 Gene

Genes around NPFFR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPFFR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPFFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFFR1 Gene

Proteins for NPFFR1 Gene

  • Protein details for NPFFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ6-NPFF1_HUMAN
    Recommended name:
    Neuropeptide FF receptor 1
    Protein Accession:
    Q9GZQ6
    Secondary Accessions:
    • A2RRF0
    • Q8NGR0
    • Q96RN3

    Protein attributes for NPFFR1 Gene

    Size:
    430 amino acids
    Molecular mass:
    47819 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPFFR1 Gene

Proteomics data for NPFFR1 Gene at MOPED

Post-translational modifications for NPFFR1 Gene

  • Glycosylation at Asn 10, Asn 18, Asn 29, Asn 113, and Asn 195
  • Modification sites at PhosphoSitePlus

Other Protein References for NPFFR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NPFFR1 Gene

Domains & Families for NPFFR1 Gene

Gene Families for NPFFR1 Gene

Suggested Antigen Peptide Sequences for NPFFR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZQ6

UniProtKB/Swiss-Prot:

NPFF1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPFFR1: view

Function for NPFFR1 Gene

Molecular function for NPFFR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with NPFFR1: view
genes like me logo Genes that share phenotypes with NPFFR1: view

Animal Models for NPFFR1 Gene

MGI Knock Outs for NPFFR1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPFFR1 Gene

Localization for NPFFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFFR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPFFR1 Gene COMPARTMENTS Subcellular localization image for NPFFR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for NPFFR1 Gene

Pathways & Interactions for NPFFR1 Gene

genes like me logo Genes that share pathways with NPFFR1: view

Pathways by source for NPFFR1 Gene

SIGNOR curated interactions for NPFFR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:1901652 response to peptide IBA --
genes like me logo Genes that share ontologies with NPFFR1: view

Drugs & Compounds for NPFFR1 Gene

(15) Drugs for NPFFR1 Gene - From: Novoseek, IUPHAR, DGIdb, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
neuropeptide FF Pharma Full agonist, Agonist Endogenous NPFF1 and NPFF2 agonist 0
BIBP3226 Pharma Antagonist 0
[<sup>125</sup>I]1DMe Pharma Full agonist, Agonist 0
[<sup>125</sup>I]NPFF Pharma Full agonist, Agonist 0
[<sup>125</sup>I]Y-RFRP-3 Pharma Full agonist, Agonist 0

(5) Additional Compounds for NPFFR1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BIBP 3226 trifluoroacetate
1068148-47-9
Neuropeptide SF (mouse, rat)
230960-31-3
RFRP 3 (human)
311309-27-0
RFRP-1 (human)
311309-25-8

(5) Tocris Compounds for NPFFR1 Gene

Compound Action Cas Number
BIBP 3226 trifluoroacetate Mixed NPY Y1 and NPFF receptor antagonist 1068148-47-9
Neuropeptide FF Endogenous NPFF1 and NPFF2 agonist 99566-27-5
Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist 230960-31-3
RFRP 3 (human) NPFF1 agonist; GnIH homolog 311309-27-0
RFRP-1 (human) Potent NPFF receptor agonist 311309-25-8
genes like me logo Genes that share compounds with NPFFR1: view

Transcripts for NPFFR1 Gene

mRNA/cDNA for NPFFR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPFFR1 Gene

Neuropeptide FF receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR1 Gene

No ASD Table

Relevant External Links for NPFFR1 Gene

GeneLoc Exon Structure for
NPFFR1
ECgene alternative splicing isoforms for
NPFFR1

Expression for NPFFR1 Gene

mRNA expression in normal human tissues for NPFFR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPFFR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.8), Brain - Cerebellum (x7.8), and Nerve - Tibial (x4.3).

SOURCE GeneReport for Unigene cluster for NPFFR1 Gene Hs.302026

genes like me logo Genes that share expression patterns with NPFFR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NPFFR1 Gene

Orthologs for NPFFR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPFFR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPFFR1 35
  • 89.67 (n)
  • 89.04 (a)
NPFFR1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPFFR1 35
  • 89.2 (n)
  • 88.42 (a)
mouse
(Mus musculus)
Mammalia Npffr1 35
  • 86.12 (n)
  • 86.98 (a)
Npffr1 16
Npffr1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPFFR1 35
  • 99.15 (n)
  • 98.6 (a)
NPFFR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npffr1 35
  • 86.12 (n)
  • 86.51 (a)
oppossum
(Monodelphis domestica)
Mammalia NPFFR1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPFFR1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPFFR1 35
  • 75.77 (n)
  • 74.48 (a)
NPFF1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPFFR1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npffr1 35
  • 65.8 (n)
  • 69.97 (a)
zebrafish
(Danio rerio)
Actinopterygii npffr1l3 35
  • 68.04 (n)
  • 65.51 (a)
NPFFR1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SIFR 36
  • 16 (a)
OneToMany
Species with no ortholog for NPFFR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPFFR1 Gene

ENSEMBL:
Gene Tree for NPFFR1 (if available)
TreeFam:
Gene Tree for NPFFR1 (if available)

Paralogs for NPFFR1 Gene

(8) SIMAP similar genes for NPFFR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPFFR1: view

Variants for NPFFR1 Gene

Sequence variations from dbSNP and Humsavar for NPFFR1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3812694 - 70,255,817(+) CACGA(G/T)GCAGC reference, missense
rs883166 -- 70,283,274(-) GGGGT(G/T)CCTCT intron-variant
rs713382 -- 70,278,270(+) TCTCA(C/T)AGTCA intron-variant
rs958448 -- 70,279,079(+) TCCAT(C/T)AAATA intron-variant
rs868075 -- 70,278,643(-) GGATA(C/T)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPFFR1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831908 CNV Gain 17160897

Variation tolerance for NPFFR1 Gene

Gene Damage Index Score: 7.40; 81.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPFFR1 Gene

HapMap Linkage Disequilibrium report
NPFFR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFFR1 Gene

Disorders for NPFFR1 Gene

Relevant External Links for NPFFR1

Genetic Association Database (GAD)
NPFFR1
Human Genome Epidemiology (HuGE) Navigator
NPFFR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPFFR1

No disorders were found for NPFFR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPFFR1 Gene

Publications for NPFFR1 Gene

  1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PMID: 11024015) Bonini J.A. … Borowsky B. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PMID: 11025660) Hinuma S. … Fujino M. (Nat. Cell Biol. 2000) 3 23
  3. Mutational analysis of the genes encoding RFamide-related peptide-3, the human orthologue of gonadotrophin-inhibitory hormone, and its receptor (GPR147) in patients with gonadotrophin-releasing hormone-dependent pubertal disorders. (PMID: 25180599) Lima C.J. … Lofrano-Porto A. (J. Neuroendocrinol. 2014) 3
  4. Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus. (PMID: 22064075) Iwasa T. … Tsutsui K. (Int. J. Dev. Neurosci. 2012) 3
  5. The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells. (PMID: 22691551) Oishi H. … Leung P.C. (Endocrinology 2012) 3

Products for NPFFR1 Gene

Sources for NPFFR1 Gene

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