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NPFFR1 Gene

protein-coding   GIFtS: 60
GCID: GC10M072014

Neuropeptide FF Receptor 1

(Previous name: G protein-coupled receptor 147)
(Previous symbol: GPR147)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptide FF Receptor 11 2     G-Protein Coupled Receptor 1472 3
GPR1471 2 3     RFamide-Related Peptide Receptor OT7T0222 3
NPFF12 3 5     NPFF1R12
G Protein-Coupled Receptor 1471 2     OT7T0222
Neuropeptide FF 11 2     

External Ids:    HGNC: 174251   Entrez Gene: 641062   Ensembl: ENSG000001487347   OMIM: 6074485   UniProtKB: Q9GZQ63   

Export aliases for NPFFR1 gene to outside databases

Previous GC identifers: GC10M071685 GC10M066007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPFFR1 Gene:
NPFFR1 (neuropeptide FF receptor 1) is a protein-coding gene. Diseases associated with NPFFR1 include neuroblastoma, and lymphoblastic leukemia. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NPFF1_HUMAN, Q9GZQ6
Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating
peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This
receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second
messenger system

summary for NPFFR1 Gene:
Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein coupled receptors that are divided into two
subtypes; NPFF1 and NPFF2. NPFF receptors act through inhibition of adenylyl cyclase and activation of
phospholipase C and are coupled to voltage-gated N-type calcium channels. NPFF receptors have been
implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception through
modulation of the opioid system. NPFF receptors are distributed across the central nervous system, but each
subtype has specific localizations. NPFF1 are found in their highest concentrations in the septum, nucleus
of the tractus solitarius and hypothalamus, suggesting their participation in neuroendocrine functions.
NPFF2 are found in their highest concentrations in the diencephalon and superficial layers of the spinal
cord, suggesting their participation in the modulation of pain. The human genes encoding NPFF1 and NPFF2
receptors are located on chromosomes 4q21 and 10q21-22 respectively.

Gene Wiki entry for NPFFR1 (Neuropeptide FF receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPFFR1 gene promoter:
         p53   Pax-5   Bach2   GATA-1   YY1   AREB6   MZF-1   SRY   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPFFR1 promoter sequence
   Search Chromatin IP Primers for NPFFR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPFFR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q22   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21-q22

NPFFR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPFFR1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M072014:  view genomic region     (about GC identifiers)

Start:
72,007,085 bp from pter      End:
72,043,450 bp from pter
Size:
36,366 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPFF1_HUMAN, Q9GZQ6 (See protein sequence)
Recommended Name: Neuropeptide FF receptor 1  
Size: 430 amino acids; 47819 Da
Sequence caution: Sequence=BAC05950.1; Type=Erroneous gene model prediction;
Secondary accessions: A2RRF0 Q8NGR0 Q96RN3

Explore the universe of human proteins at neXtProt for NPFFR1: NX_Q9GZQ6

Explore proteomics data for NPFFR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn18, Asn29, Asn113, Asn195
  • Modification sites at PhosphoSitePlus

  • See NPFFR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071429.1  
    ENSEMBL proteins: 
     ENSP00000277942  
    Reactome Protein details: Q9GZQ6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RFAPR: GPCR / Class A : RF amide peptide receptors
    NPFFR: GPCR / Class A : Neuropeptide receptors : FF/AF

    IUPHAR Guide to PHARMACOLOGY protein family classification: NPFF1 receptor
    Neuropeptide FF/neuropeptide AF receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005396 NPFF_rcpt_1
     IPR005395 NPFF_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9GZQ6

    ProtoNet protein and cluster: Q9GZQ6

    2 Blocks protein domains:
    IPB005395 Neuropeptide FF receptor family signature
    IPB005396 Type 1 neuropeptide FF receptor signature


    UniProtKB/Swiss-Prot: NPFF1_HUMAN, Q9GZQ6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NPFFR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPFF1_HUMAN, Q9GZQ6
    Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating
    peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This
    receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second
    messenger system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity NAS11024015
    GO:0008188neuropeptide receptor activity NAS11024015
         
    NPFFR1 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPFF1_HUMAN, Q9GZQ6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    NPFFR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPFFR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Orexin and neuropeptides FF and QRFP bind to their respective receptors0.00
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NPFFR1
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for NPFFR1
        Orexin and neuropeptides FF and QRFP bind to their respective receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for NPFFR1):
        Neuroactive ligand-receptor interaction


    NPFFR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NPFFR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPFFR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPFFR1 (Q9GZQ63 ENSP000002779424) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPFFO151303, ENSP000002670174I2D: score=1 STRING: ENSP00000267017
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    CCKENSP000003356574STRING: ENSP00000335657
    GNRH1ENSP000002764144STRING: ENSP00000276414
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007218neuropeptide signaling pathway NAS11024015
    GO:0008150biological_process ND--

    NPFFR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NPFFR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist[230960-31-3]
    RFRP 3 (human)NPFF1 agonist; GnIH homolog[311309-27-0]
    RF 9Selective NPFF1 and NPFF2 antagonist[876310-60-0]

    1 HMDB Compound for NPFFR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for NPFFR1 (NPFF1 receptor) (see all 14)    About this table
    LigandTypeActionAffinityPubmed IDs
    neuropeptide FF
    AgonistFull agonist8.5 - 9.912421602 12242085 17011599
    [125I]Y-RFRP-3
    AgonistFull agonist9.712421602
    Y-RFRP-3
    AgonistFull agonist9.412421602 12242085
    RFRP-3
    AgonistFull agonist9.2 - 9.312421602 12242085 17337079
    1DMe
    AgonistFull agonist8.1 - 912421602 11024015 17011599
    [125I]1DMe
    AgonistFull agonist8.911024015
    [3H]NPVF
    AgonistFull agonist8.619682524
    AC262970
    AntagonistAntagonist7.4 - 8.120354177
    AC262620
    AntagonistAntagonist7.7 - 8.120354177
    BIBP3226
    AntagonistAntagonist7 - 7.812421602 11024015 12242085

    2 Novoseek inferred chemical compound relationships for NPFFR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    npff 96 12 19922753 (3), 12242085 (2), 11024015 (1)
    bibp3226 85.9 2 11024015 (1)



    NPFFR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NPFFR1 gene: 
    NM_022146.4  

    Unigene Cluster for NPFFR1:

    Neuropeptide FF receptor 1
    Hs.302026  [show with all ESTs]
    Unigene Representative Sequence: NM_022146
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000277942(uc021psj.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NPFFR1
      QuantiFast Probe-based Assays in human, mouse, rat NPFFR1

    Additional mRNA sequence: 

    AB040104.1 AF268898.1 AF330055.1 BC131580.1 EU432128.1 

    3 DOTS entries:

    DT.102825062  DT.92020022  DT.121271953 

    18 AceView cDNA sequences:

    AB040104 AF268898 NM_022146 CD631252 CD631268 CD631258 CD631262 CD631256 
    AF330055 CD631254 CD631250 CD631260 CD631266 CD631246 CD631264 CD631242 
    CD631247 CD631244 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPFFR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGCTGT
    NPFFR1 Expression
    About this image

    NPFFR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPFFR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302026
        Pathway & Disease-focused RT2 Profiler PCR Array including NPFFR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPFFR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPFFR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npffr11 , 5 neuropeptide FF receptor 11, 5 86.12(n)1
    86.98(a)1
      10 (32.24 cM)5
    2373621  NM_001177511.11  NP_001170982.11 
     615954845 
    chicken
    (Gallus gallus)
    Aves NPFFR11 neuropeptide FF receptor 1 75.77(n)
    74.48(a)
      378784  NM_204362.1  NP_989693.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPFFR16
    neuropeptide FF receptor 1
    65(a)
    1 ↔ 1
    3(51192354-51227204)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npffr11 neuropeptide FF receptor 1 65.8(n)
    69.97(a)
      101733377  XM_004915786.1  XP_004915843.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npffr1l31 neuropeptide FF receptor 1 like 3 68.04(n)
    65.51(a)
      561324  NM_001089389.1  NP_001082858.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SIFR6
    SIFamide receptor
    16(a)
    1 → many
    3R(17102386-17119720)


    ENSEMBL Gene Tree for NPFFR1 (if available)
    TreeFam Gene Tree for NPFFR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPFFR1 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPY2R2  QRFPR2  HCRTR12  TACR22  
    8 SIMAP similar genes for NPFFR1 using alignment to 1 protein entry:     NPFF1_HUMAN:
    NPFFR2    DRD3    NPY2R    NPY1R    GPR83    NPY4R
    PRLHR    NPY6R

    NPFFR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPFFR1 (see all 736)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118184391,2
    C,F,H--72014239(+) TTTTCG/ACTTCT 1 -- ds500113Minor allele frequency- A:0.08NS NA WA 1704
    rs1496185191,2
    --72014315(+) CAGCTA/GGAGAT 1 -- ds50010--------
    rs1433194361,2
    --72014379(+) TGAGAA/GACTTG 1 -- ds50010--------
    rs775878611,2
    C,F--72014387(+) TTGGGT/CGAGTC 1 -- ds50011Minor allele frequency- C:0.11WA 118
    rs1845110031,2
    --72014407(+) CAGGCC/TTCAGT 1 -- ds50010--------
    rs1480080071,2
    --72014443(+) GACAAC/TCTATC 1 -- ds50010--------
    rs773433851,2
    C,F--72014560(+) CAGCAG/AAGAAG 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs70762621,2
    C,F--72014656(+) CCTGCA/GTGTAT 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs123565131,2
    H--72014671(+) TGTCCA/GATCGG 1 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs19996241,2
    C,F,A--72014779(-) CACCAC/TGGCTT 2 H syn1 ese36Minor allele frequency- T:0.08NA NS WA EA 406

    HapMap Linkage Disequilibrium report for NPFFR1 (72007085 - 72043450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NPFFR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831908CNV Gain17160897
    esv32737CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607448    OMIM disorders: --

    5 diseases for NPFFR1:    
    About MalaCards
    neuroblastoma    lymphoblastic leukemia    alzheimer's disease    pancreatitis
    leukemia


    NPFFR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NPFFR1
    Human Genome Epidemiology (HuGE) Navigator: NPFFR1 (2 documents)

    Export disorders for NPFFR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPFFR1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NPFFR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PubMed id 11024015)1, 2, 3, 9 Bonini J.A....Borowsky B. (J. Biol. Chem. 2000)
    2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PubMed id 11025660)1, 2, 9 Hinuma S.... Fujino M. (Nat. Cell Biol. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus. (PubMed id 22064075)1 Iwasa T....Tsutsui K. (Int. J. Dev. Neurosci. 2012)
    6. The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells. (PubMed id 22691551)1 Oishi H....Leung P.C. (Endocrinology 2012)
    7. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. (PubMed id 23007406)1 Yang J.J....Relling M.V. (Blood 2012)
    8. Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. (PubMed id 20027225)1 Ubuka T.... Bentley G.E. (PLoS ONE 2009)
    9. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (J. Biol. Chem. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64106 HGNC: 17425 AceView: GPR147 Ensembl:ENSG00000148734 euGenes: HUgn64106
    ECgene: NPFFR1 Kegg: 64106 H-InvDB: NPFFR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPFFR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPFFR1 gene:
    Search GeneIP for patents involving NPFFR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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