Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPEPPS Gene

protein-coding   GIFtS: 64
GCID: GC17P045608

Aminopeptidase Puromycin Sensitive

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aminopeptidase Puromycin Sensitive1 2     MP1002 5
PSA2 3 5     EC 3.4.11.143
Metalloproteinase MP1001 2     EC 3.4.118
Puromycin-Sensitive Aminopeptidase1 2     EC 3.4.11.28
Cytosol Alanyl Aminopeptidase2 3     EC 3.4.11.38
AAP-S2 3     

External Ids:    HGNC: 79001   Entrez Gene: 95202   Ensembl: ENSG000001412797   OMIM: 6067935   UniProtKB: P557863   

Export aliases for NPEPPS gene to outside databases

Previous GC identifers: GC17P035973 GC17P048089 GC17P045950 GC17P046083 GC17P042963 GC17P041029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPEPPS Gene:
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids
from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular
membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in
proteolytic events regulating the cell cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for NPEPPS Gene: 
NPEPPS (aminopeptidase puromycin sensitive) is a protein-coding gene. Diseases associated with NPEPPS include high pressure neurological syndrome, and tauopathy, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include aminopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: PSA_HUMAN, P55786
Function: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events
essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the
antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell
epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain
more efficiently than tau from Alzheimer disease brain

Gene Wiki entry for NPEPPS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPEPPS gene promoter:
         Sp1   Pax-5   Meis-1b   FOXL1   Egr-4   GATA-1   MEF-2A   Msx-1   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPEPPS promoter sequence
   Search SABiosciences Chromatin IP Primers for NPEPPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPEPPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q12-q21

NPEPPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPEPPS gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045608:  view genomic region     (about GC identifiers)

Start:
45,600,306 bp from pter      End:
45,700,642 bp from pter
Size:
100,337 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PSA_HUMAN, P55786 (See protein sequence)
Recommended Name: Puromycin-sensitive aminopeptidase  
Size: 919 amino acids; 103276 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Monomer
Subcellular location: Cytoplasm, cytosol. Nucleus (Potential)
Caution: It is uncertain whether Met-1 or Met-45 is the initiator. N-terminal sequencing in PubMed:10978616
suggests that Met-45 is used, followed by methionine initiator removal
Sequence caution: Sequence=AAH65294.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA68964.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6P145 Q9NP16 Q9UEM2

Explore the universe of human proteins at neXtProt for NPEPPS: NX_P55786

Explore proteomics data for NPEPPS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55786

  • 4/6 DME Specific Peptides for NPEPPS (P55786) (see all 6)
     WLNEGFA  STYLVAF  WFGNLVT  GAMENWG 

    NPEPPS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPEPPS Protein Expression
    REFSEQ proteins: NP_006301.3  
    ENSEMBL proteins: 
     ENSP00000437019   ENSP00000433287   ENSP00000433735   ENSP00000434554   ENSP00000320324  
     ENSP00000434585   ENSP00000433649   ENSP00000435639   ENSP00000436733   ENSP00000435966  
     ENSP00000432127   ENSP00000433549   ENSP00000442461  
    Reactome Protein details: P55786
    Human Recombinant Protein Products for NPEPPS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NPEPPS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPEPPS
    GenScript Custom Purified and Recombinant Proteins Services for NPEPPS
    Novus Biologicals NPEPPS Protein
    Novus Biologicals NPEPPS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    NPEPPS for ontologies           About GeneDecksing



    NPEPPS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NPEPPS
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NPEPPS
    OriGene Custom Antibody Services for NPEPPS
    GenScript Custom Superior Antibodies Services for NPEPPS
    Novus Biologicals NPEPPS Antibodies
    Abcam antibodies for NPEPPS
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for NPEPPS
    LSBio Antibodies in human, mouse, rat for NPEPPS 

    Assay Products for NPEPPS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPEPPS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPEPPS
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Puromycin-sensitive aminopeptidase 
    Aminopeptidases

    4 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 DUF3358
     IPR015568 Peptidase_M1_puromycin-sens
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry P55786

    ProtoNet protein and cluster: P55786

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: PSA_HUMAN, P55786
    Similarity: Belongs to the peptidase M1 family


    NPEPPS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PSA_HUMAN, P55786
    Function: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events
    essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the
    antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell
    epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain
    more efficiently than tau from Alzheimer disease brain
    Catalytic activity: Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides,
    amides and arylamides
    Enzyme regulation: Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP,
    PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly
    inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+)
    Biophysicochemical properties: Kinetic parameters: KM=2.20 mM for Lys-p-NA; KM=0.25 mM for Leu-p-NA; KM=0.27 mM
    for Ala-p-NA; KM=0.80 mM for Met-p-NA; KM=0.47 mM for Pro-p-NA; KM=0.21 mM for Val-p-NA; KM=182 uM for Ala-MCA;
    KM=189 uM for Met-MCA; KM=220 uM for Lys-MCA; KM=91 uM for Leu-MCA; KM=167 uM for Phe-MCA; pH dependence: Optimum
    pH is 7.5. Stable from pH 5.0 to 8.0; Temperature dependence: Stable up to 40 degrees Celsius;

         Genatlas biochemistry entry for NPEPPS:
    aminopeptidase puromycin sensitive,expressed in the brain (most abundant aminopeptidase),localized in cortical and
    cerebellar neurons,putatively contributing to the degradation of enkephalins

         Enzyme Numbers (IUBMB): EC 3.4.11.32 EC 3.4.11.141 EC 3.4.11.22 EC 3.4.112

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    NPEPPS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NPEPPS:
     Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Npepps):
     behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system 
     integument  mortality/aging  reproductive system 

    NPEPPS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPEPPS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPEPPS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPEPPS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPEPPS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPEPPS
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate NPEPPS (see all 56):
    hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4274 hsa-miR-489 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidNPEPPS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPEPPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPEPPS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPEPPS
    Sirion Biotech Customized adenovirus for overexpression of NPEPPS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NPEPPS (see all 9)
    OriGene ORF clones in mouse, rat for NPEPPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPEPPS (NM_006310)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPEPPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPPS
    Sirion Biotech Customized lentivirus for stable overexpression of NPEPPS 
                         Customized lentivirus expression plasmids for stable overexpression of NPEPPS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPEPPS
    Search LifeMap BioReagents cell lines for NPEPPS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPPS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPEPPS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Selected targets of GCR-alpha
    Selected targets of GCR-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NPEPPS
        Selected targets of GCR-alpha


    4        Reactome Pathways for NPEPPS
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System



    NPEPPS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPEPPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/117 Interacting proteins for NPEPPS (P557861, 3 ENSP000003203244) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006508proteolysis IEA--
    GO:0071456cellular response to hypoxia IDA--

    NPEPPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NPEPPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPEPPS (PSA)

    6 Novoseek inferred chemical compound relationships for NPEPPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thimet 76 2 14734113 (1)
    puromycin 74.8 21 17154549 (4), 9244402 (3), 11082703 (2), 20377816 (2) (see all 6)
    bestatin 72.5 2 11082703 (1)
    bleomycin 55.3 6 15187416 (1), 12200051 (1), 14734113 (1), 16455981 (1)
    leucine 35.1 3 15187416 (1), 16455981 (1)
    glutamine 12.4 4 17318184 (2), 12729622 (1)

    Search CenterWatch for drugs/clinical trials and news about NPEPPS / PSA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPEPPS gene: 
    NM_006310.3  

    Unigene Cluster for NPEPPS:

    Aminopeptidase puromycin sensitive
    Hs.443837  [show with all ESTs]
    Unigene Representative Sequence: NM_006310
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000527200 ENST00000525007 ENST00000525037(uc010dba.1) ENST00000528751
    ENST00000530173 ENST00000526247 ENST00000532729 ENST00000322157(uc010wkt.2 uc002ilr.4 uc010wku.2 uc010wkv.2)
    ENST00000533573 ENST00000527298 ENST00000534691 ENST00000602788 ENST00000527824
    ENST00000534727 ENST00000534814 ENST00000525401 ENST00000527964 ENST00000530514

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPEPPS
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate NPEPPS (see all 56):
    hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4274 hsa-miR-489 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidNPEPPS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPEPPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPEPPS
    Clone
    Products:
         
    OriGene clones in human, mouse for NPEPPS (see all 9)
    OriGene ORF clones in mouse, rat for NPEPPS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPEPPS (NM_006310)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPEPPS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPPS
    Sirion Biotech Customized lentivirus for stable overexpression of NPEPPS 
                         Customized lentivirus expression plasmids for stable overexpression of NPEPPS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NPEPPS
    OriGene qSTAR qPCR primer pairs in human, mouse for NPEPPS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPEPPS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPPS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPPS

    Additional mRNA sequence: 

    AJ132583.1 AK095877.1 AK096491.1 AK096709.1 AK293450.1 AK293995.1 AK296887.1 AK297107.1 
    AK303037.1 BC065294.1 BC067792.1 NR_036750.1 XR_172201.1 

    24/37 DOTS entries (see all 37):

    DT.85104799  DT.91934981  DT.100810296  DT.100824478  DT.70101756  DT.91811703  DT.102843581  DT.100727004 
    DT.100824472  DT.40117560  DT.120896689  DT.91883443  DT.100640887  DT.120896634  DT.86835850  DT.120896722 
    DT.419664  DT.91982917  DT.97864464  DT.99987084  DT.100809252  DT.100824473  DT.120896643  DT.120896678 

    558 AceView cDNA sequences (see top 24):

    BM474975 BM678027 BM750492 BU618303 AW249850 AW572592 AL134687 BM676084 
    AW161660 F04707 BQ937998 BP375065 AI201527 AA379056 AU130524 AI922696 
    AA551216 BE467460 AW515849 NM_006310 AA527546 BU159521 AI371747 BG764490 
    CB151935 BQ948869 CB135450 H88733 AI819033 AI358780 AU131519 CD365956 
    CB055080 AU138954 BE901545 AA356510 AA477344 BQ773180 AA043325 AA719692 
    CB052405 BP380236 CB132321 AA775234 BE255877 AI417739 BQ637169 AW160904 
    W61096 BE745151 BF725638 AI362992 CB131887 N25833 CB134338 AU130809 
    AA716290 AA781991 AU124313 AW474894 AA700786 AU132025 AJ132583 AW382841 
    CF265037 AW262710 BU617836 BP357023 AI907616 CB140805 CF264918 AW662871 
    H92317 CA425164 BQ918409 AI174493 BM787396 BE859000 BE513530 BU789091 
    BE253168 Z46195 AL704975 AA962342 AA811175 AI874115 AA236597 BU146748 
    AW055008 BU164354 BC065294 BG396605 CA442789 Z45846 AW250513 CB134491 
    BM462940 AI923340 BQ427986 CB989477 AA235023 BG251111 BX328339 AI469313 
    AI086732 BU521772 AA583041 AI350198 BG153399 N29798 CB113327 AU143030 
    AW418772 AA243024 BU752283 BM990894 AI500415 AA680041 AA488024 AI093936 
    BU683295 BQ719524 CA440448 BE742650 BX456502 CD109455 CA407052 BM693061 
    BP358177 BE207218 CD675080 BQ962241 BM992634 AA281550 W63744 BE267830 
    AW672944 AK095877 BE795169 BX102891 BM563450 AU127507 CF994692 BQ310617 
    BM849758 AI273075 AA634383 AA278470 AA811730 CD559018 BM451833 W78070 
    BQ000550 AA335436 BQ441250 BM784932 BF672777 CF145382 D25741 BP356949 
    BQ900424 BM725920 BM832631 BE251429 BQ719994 BU855913 AA379160 CA314846 
    BM475550 BG706059 BG661294 AW075412 CF145628 AA043567 BM979526 BE275861 
    BU934427 BM476747 AA234379 BQ348046 BQ070094 BI599212 AI869693 T59824 
    W58047 AI139445 AW068750 AW084189 N46683 BQ188211 BE256005 AA495731 
    BE251921 CB147473 CK000284 AA480335 BQ941006 BE397119 AA628984 AA758107 
    BQ712415 BG762884 CB266556 AA631531 CB055081 BM313699 AV661605 CB218100 
    BM972238 CD511451 BX456503 CF595922 AI300613 BQ952951 AA448981 BF973367 
    BG057718 AU120035 BU855893 BE869805 BM968056 AI016872 BM313967 CB990789 
    BG394660 BE408743 CA450360 BQ001462 CB989405 BX359408 AK096491 AW250785 
    BG250615 BG505128 AI218271 BE396912 R37619 BE559914 BU542979 AI377963 
    BQ028600 AI001942 BM472257 BG117696 BE018888 AK096709 BU679613 AA086030 
    BP349898 BU679227 BM826470 BV197398 CB241315 AI018254 BM750714 AW845107 
    AW190703 BQ375649 BM836610 CB157712 BU160677 BX394931 AL691857 BU557086 
    BF570396 AL600621 BI668994 BE208326 BQ433868 BE255386 BM465967 BX372385 
    AI351223 BG282157 BQ003625 AA479773 AW173229 BU539936 AA430444 AI300615 
    AU129063 BE932162 AI979157 BG495510 BG723972 AA972560 AA887191 BQ422583 
    AI952713 BI823169 BG437888 BM744473 BV197397 AA953827 AA379057 CA445162 
    AA487910 AA053733 BE891170 BX101652 BV197399 AA281551 AI934766 BG481841 
    AA864462 AI241288 BM819607 F35993 AI910502 AI342805 AA503249 BQ189539 
    BX433818 AA076585 BE278478 BF037923 BM979078 BU567874 AA306767 AI290813 
    AA705351 BE207210 BI053090 CD519373 BQ005087 BG769951 BQ310628 AI721203 
    D53060 H02286 BQ220099 T35931 AU127167 BG419019 BF577064 BQ310625 
    AI911617 BQ349530 AW166905 BE739610 BF980621 T35932 AA889307 AI242109 
    W92575 AA043326 AW148960 BE730943 BQ694265 BG231987 AA707861 AA760940 
    BQ310627 AI129440 BX359409 BI598992 AA192252 AW183101 N39239 BM014569 
    BE267755 BE156288 BG395151 AA724245 BG876691 BU789353 BI870579 CF121316 
    BE813888 N29793 BG176950 AI219289 D60291 BE885612 CB135145 AU153244 
    AW305272 BP359050 BF211613 BQ314792 N42938 W88933 BE730014 W92574 
    BF982931 AA682926 AA514686 BF034725 BQ185665 BE813599 AW241819 AA884277 
    AA076640 BX394930 W60835 BG929397 BP340227 Y07701 BG434492 BE714597 
    BG661237 BM795942 BM512171 BF807669 AA235018 AW939491 BU625927 AU150077 
    C15614 AA883761 BI598439 AI191221 BI043274 BI094166 R81278 AU151245 
    AW246924 AA654057 AW996579 BE397120 BG828824 CA417374 AW014674 AA043238 
    BQ575372 BG718524 BI668398 AA572893 BG420243 AA026655 N26972 AI904679 
    BF665409 CD639761 AW939556 AW615663 AI362571 D55858 BF697066 BF350071 
    BE814026 R39082 AA076586 BQ310619 BM019716 BM051628 D52240 AW593091 
    BE245328 AW104219 AI922960 AA969976 BE269835 BF569910 BF940879 BM723238 
    BE268380 BQ334390 BQ310626 AU153648 AW408104 BX457343 W89190 BG705604 
    BE258771 AI500627 BM929389 AW131941 BP334098 BG480967 BE706782 AU160198 
    BM755023 BE153810 BQ325840 BQ348655 BF807670 AW958347 BX461945 AA194661 
    AU152439 H98949 AI907733 BQ310624 BE183523 BF836632 CB218099 BF093444 
    W60836 AA913019 AW963761 AA657509 R81001 AW170785 AV735613 H99098 
    AA079607 BF229139 H41942 N42944 BX401883 BQ351097 AW602555 AI468893 
    BE073976 AI251582 CD643130 H88732 AU151611 BF093410 T79910 AU149845 
    H00819 BI824218 AW606202 BF941265 BM557851 AW383460 BF834428 BP358664 
    AA216452 BG223461 BQ334568 BG541040 H02390 BG748343 AA053549 AW512435 
    BM013925 N87603 BE071437 BE706589 AW276194 BQ423674 CA503369 R43275 
    AI251220 AW382860 H01206 BF909118 BQ303196 AW382861 CB987369 BE154037 
    BG991658 BF834454 BF759390 R18906 BI601015 H41106 BE900701 BE153811 
    BQ027443 BU587176 BQ361767 AI054305 AA085988 AI054261 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NPEPPS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^
    SP1:                                                                          -                       -                                               -     -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  


    ECgene alternative splicing isoforms for NPEPPS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPEPPS expression in normal human tissues (normalized intensities)      NPEPPS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGGAAAGC
    NPEPPS Expression
    About this image


    NPEPPS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Lung (Respiratory System)
             Trachea
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See NPEPPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPEPPS

    SOURCE GeneReport for Unigene cluster: Hs.443837

    UniProtKB/Swiss-Prot: PSA_HUMAN, P55786
    Tissue specificity: Detected in liver, epithelium of renal tubules, epithelium of small and large intestine,
    gastric epithelial cells, and alveoli of the lung (at protein level)

        SABiosciences Custom PCR Arrays for NPEPPS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NPEPPS
    OriGene qSTAR qPCR primer pairs in human, mouse for NPEPPS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPEPPS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPPS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPPS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NPEPPS gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npepps1 , 5 aminopeptidase puromycin sensitive1, 5 93.28(n)1
    97.71(a)1
      11 (60.95 cM)5
    191551  NM_008942.21  NP_032968.21 
     972058425 
    chicken
    (Gallus gallus)
    Aves NPEPPS1 aminopeptidase puromycin sensitive 84.31(n)
    91.84(a)
      426231  XM_001234985.2  XP_001234986.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    91(a)
    1 → many
    6(74082401-74177355)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA987419.12   -- 77.26(n)    CA987419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055665.12   -- 76.64(n)    BC055665.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psa1 , 3 cytosol alanyl aminopeptidase3
    Puromycin sensitive aminopeptidase1
    56(a)
    (best of 3)3
    56.59(n)1
    56.98(a)1
      381751  NM_167887.21  NP_728618.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F49E8.33
    pam-11
    Protein PAM-11 39(a)
    (best of 5)3
    49.84(n)1
    39.84(a)1
      IV(7544328-7547304)3
    1775281  NM_001028039.11  NP_001023210.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAP1(YHR047C)4
    APE21
    Arginine/alanine aminopeptidase, overproduction stimulates more4
    Ape2p1
    47.14(n)1
    36.75(a)1
      8(201310-198740)4
    8536991  NP_012765.31  8564434 
     NP_011913.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APM11 aminopeptidase M1 53.2(n)
    47.4(a)
      829446  NM_119463.4  NP_195035.2 
    rice
    (Oryza sativa)
    Liliopsida AK120068.12   -- 75.43(n)    AK120068.1 


    ENSEMBL Gene Tree for NPEPPS (if available)
    TreeFam Gene Tree for NPEPPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPEPPS gene
    LNPEP2  ENPEP2  ANPEP2  TRHDE2  ERAP12  AQPEP2  ERAP22  
    8 SIMAP similar genes for NPEPPS using alignment to 13 protein entries:     PSA_HUMAN (see all proteins):
    NPEPPSL1    TBC1D3    ANPEP    TRHDE    ENPEP    LNPEP
    ERAP2    ERAP1

    NPEPPS for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NPEPPS
    PGOHUM00000258041 PGOHUM00000258042


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1709 SNPs in NPEPPS are shown (see all 1709)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814450841,2
    --45606581(+) ACTTTA/GAATAA 1 -- us2k10--------
    rs98911181,2
    C,A,H--45606584(+) TTAAAA/G/TAACAT 1 -- us2k15NA WA 14
    rs26119881,2
    C,H--45606594(-) AATTTA/TAAAAA 1 -- us2k10--------
    rs794814291,2
    F--45606809(+) GTTGTA/CGCCCA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs2000296081,2
    C--45607102(+) GTTACA/TTTATA 1 -- us2k10--------
    rs2011055901,2
    C--45607103(+) TTACAA/TTATAT 1 -- us2k10--------
    rs1865646531,2
    --45607167(+) AAGGTA/GTCTAC 1 -- us2k10--------
    rs2005383591,2
    C--45607285(+) CCCAT-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs1910746351,2
    --45607312(+) TATTTA/TTTTAT 1 -- us2k10--------
    rs1828670801,2
    --45607316(+) TATTTA/TTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPEPPS (45600306 - 45700642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for NPEPPS (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675559CNV Deletion23128226
    esv2716010CNV Deletion23290073
    nsv471513CNV Duplication19718026
    nsv471403CNV Duplication19718026
    nsv821341CNV Duplication20802225
    esv33689CNV Loss17666407
    nsv471701CNV Gain15918152
    nsv428344CNV Gain18775914
    nsv482203CNV Gain20164927
    nsv828034CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPEPPS
    DNA2.0 Custom Variant and Variant Library Synthesis for NPEPPS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606793    OMIM disorders: --

    13 diseases for NPEPPS:    About MalaCards
    high pressure neurological syndrome    tauopathy    clear cell renal cell carcinoma    renal cell carcinoma
    dementia    alzheimer's disease    pneumonia    prostate cancer
    prostatitis    hypoxia    tuberculosis    squamous cell carcinoma
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for NPEPPS:
    Schizophrenia     Bipolar disorder

    NPEPPS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for NPEPPS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tauopathies 64.1 2 16950154 (2)
    alzheimers disease 6.57 1 17476590 (1)
    tumors 0 4 16985214 (1), 12431818 (1)
    prostate cancer 0 2 12431818 (2)

    Human Genome Epidemiology (HuGE) Navigator: NPEPPS (1 document)

    Export disorders for NPEPPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPEPPS gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with NPEPPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. (PubMed id 9048733)1, 2, 3, 9 Tobler A.R.... Fontana A. (1997)
    2. Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (PubMed id 10329370)1, 2, 3, 9 Thompson M.W.... Hersh L.B. (1999)
    3. Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. (PubMed id 11435692)1, 2, 9 Bauer W.O.... Jakob F. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. (PubMed id 17154549)2, 9 Sengupta S....Binder L.I. (2006)
    6. cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate? (PubMed id 10037494)1, 9 Huber G....Malherbe P. (1999)
    7. Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of fro ntotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau. (PubMed id 20377816)1, 9 Yanagi K....Takeda M. (2009)
    8. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. (PubMed id 17318184)2, 9 Bhutani N....Goldberg A.L. (2007)
    9. Cobalt chloride-induced downregulation of puromycin-s ensitive aminopeptidase suppresses the migration and invasion of PC-3 cells. (PubMed id 19494703)1, 9 Lee S.H. and Kim H.G. (2009)
    10. Cytosolic aminopeptidases influence MHC class I-media ted antigen presentation in an allele-dependent manner. (PubMed id 19917696)2, 9 Kim E....Ahn K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9520 HGNC: 7900 AceView: NPEPPS Ensembl:ENSG00000141279 euGenes: HUgn9520
    ECgene: NPEPPS H-InvDB: NPEPPS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPEPPS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPEPPS gene:
    Search GeneIP for patents involving NPEPPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NPEPPS
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NPEPPS   OriGene RNAi products in human, mouse, rat for NPEPPS  
     OriGene qPCR primer pairs and template standards for NPEPPS   OriGene Protein Over-expression Lysate for NPEPPS  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPEPPS  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPEPPS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPEPPS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPEPPS   OriGene Custom Protein Services for NPEPPS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPEPPS
     QIAGEN SeqTarget long-range PCR primers for resequencing NPEPPS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPEPPS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPEPPS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPPS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPPS
     GenScript Custom Purified and Recombinant Proteins Services for NPEPPS GenScript cDNA clones with any tag delivered in your preferred vector for NPEPPS
     GenScript Custom Assay Services for NPEPPS GenScript Custom Superior Antibodies Services for NPEPPS
     GenScript Custom overexpressing Cell Line Services for NPEPPS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NPEPPS promoter
     Search Chromatin IP Primers for NPEPPS
     RT2 qPCR Primer Assay in human, mouse, rat NPEPPS
     Search GNC Networks for NPEPPS
     SABiosciences Custom PCR Arrays for NPEPPS
     Search Tocris compounds for NPEPPS (PSA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPEPPS antibodies
     NPEPPS proteins
     NPEPPS lysates
     Antibodies for NPEPPS
     See all of Abcam's Antibodies, Kits and Proteins for NPEPPS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NPEPPS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPPS
     SwitchGear 3'UTR luciferase reporter plasmids for NPEPPS
     SwitchGear Promoter luciferase reporter plasmids for NPEPPS
     ThermoFisher Antibody for NPEPPS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPPS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPEPPS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPEPPS
    Customized:
     lentivirus for stable overexpression of NPEPPS
     lentivirus expression plasmids for stable overexpression of NPEPPS
     adenovirus for overexpression of NPEPPS
     LSBio Antibodies in human, mouse, rat for NPEPPS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPEPPS gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4