NPEPPS Gene

Aliases
for NPEPPS gene

Previous GC identifers: GC17P035973 GC17P048089 GC17P045950 GC17P046083 GC17P042963 GC17P041029

Summaries
for NPEPPS gene

Genomic Views
for NPEPPS gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmid: NPEPPS promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPEPPS

NPEPPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045608:  view genomic region     (about GC identifiers)

Proteins
for NPEPPS gene

Explore the universe of human proteins at neXtProt for NPEPPS: NX_P55786

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NPEPPS OriGene Custom Protein Services for NPEPPS
	GenScript Custom Purified and Recombinant Proteins Services for NPEPPS
	Novus Biologicals NPEPPS Protein Novus Biologicals NPEPPS Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NPEPPS

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NPEPPS
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): NPEPPS OriGene Custom Antibody Services for NPEPPS
	GenScript Custom Superior Antibodies Services for NPEPPS
	Novus Biologicals NPEPPS Antibodies
	Search for Antibodies for NPEPPS at Abcam
	Uscn Antibodies for NPEPPS
	ThermoFisher Antibody for NPEPPS

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NPEPPS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NPEPPS

Protein Domains /
Families
for NPEPPS gene

ProtoNet protein and cluster: P55786

Function
for NPEPPS gene

miRNA Products:		OriGene 3'-UTR Clone: NPEPPS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPEPPS
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate NPEPPS (see all 56):
		hsa-miR-1197 hsa-miR-513a-5p hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4274 hsa-miR-489 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: NPEPPS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPEPPS (see all 6) OriGene siRNA: NPEPPS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPEPPS

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NPEPPS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPPS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPPS (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NPEPPS (NM_006310)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPEPPS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPPS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NPEPPS
		Search LifeMap BioReagents cell lines for NPEPPS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPPS

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Npepps)

Pathways & Interactions
for NPEPPS gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation 1.00 Class I MHC mediated antigen processing & presentation 0.83
3	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases 1.00
4	Selected targets of GCR-alpha	Selected targets of GCR-alpha 1.00

1 EMD Millipore Pathway for NPEPPS

Selected targets of GCR-alpha

5        Reactome Pathways for NPEPPS

	Antigen processing: Ubiquitination & Proteasome degradation
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
	Immune System

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for NPEPPS gene

Transcripts
for NPEPPS gene

Expression
for NPEPPS gene

NPEPPS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAGGAAAGC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPEPPS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPEPPS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPPS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPPS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPPS

Orthologs
for NPEPPS gene

Paralogs
for NPEPPS gene

Paralogs for NPEPPS gene

LNPEP²  ENPEP²  ANPEP²  TRHDE²  ERAP1²  AQPEP²  ENSG00000174093²  ERAP2²  

8 SIMAP similar genes for NPEPPS using alignment to 13 protein entries:     PSA_HUMAN (see all proteins):

NPEPPSL1    TBC1D3    ANPEP    TRHDE    ENPEP    LNPEP

ERAP2    ERAP1

NPEPPS for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for NPEPPS
PGOHUM00000258041 PGOHUM00000258042

Genomic Variants
for NPEPPS gene

10/1575 NCBI SNPs in NPEPPS are shown (see all 1575)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1814450841,2		--	45606581(+)	ACTTTA/GAATAA	1	--	us2k1		0	--	--	--	--
rs98911181,2	C,A,H,	--	45606584(+)	TTAAAA/G/TAACAT	1	--	us2k1		5		NA WA	14
rs26119881,2	C,H,	--	45606594(-)	AATTTA/TAAAAA	1	--	us2k1		0	--	--	--	--
rs794814291,2		--	45606809(+)	GTTGTA/CGCCCA	1	--	us2k1		1		NA	2
rs1819154041,2		--	45607139(+)	CATTTA/GTATAT	1	--	us2k1		0	--	--	--	--
rs1865646531,2		--	45607167(+)	AAGGTA/GTCTAC	1	--	us2k1		0	--	--	--	--
rs1910746351,2		--	45607312(+)	TATTTA/TTTTAT	1	--	us2k1		0	--	--	--	--
rs1828670801,2		--	45607316(+)	TATTTA/TTTTTG	1	--	us2k1		0	--	--	--	--
rs29351841,2		--	45607528(-)	ttcaaG/Caccag	1	--	us2k1		1		NA	2
rs38749101,2	C,F,	--	45607563(+)	CTCGGC/TCTCCC	1	--	us2k1		2		NA	4

HapMap Linkage Disequilibrium report for NPEPPS (45600306 - 45700642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for NPEPPS
     15/19 CNVs (see all 19): 77649 72970 77650 32186 77648 88514 2229 7163 77646 88512 4039 72969 0804 88513 0328

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPEPPS

DNA2.0 Custom Variant and Variant Library Synthesis for NPEPPS

Disorders / Diseases
for NPEPPS gene

16 diseases for NPEPPS

4 Novoseek disease relationships for NPEPPS gene    About this table

Publications
for NPEPPS gene

PubMed articles for NPEPPS gene, integrated from 9 sources (see all 72) (see top 10): (articles sorted by number of sources associating them with NPEPPS)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. (PubMed id 9048733)^{1, 2, 3, 9} Tobler A.R.... Fontana A. (1997)
2. Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (PubMed id 10329370)^{1, 2, 3, 9} Thompson M.W.... Hersh L.B. (1999)
3. Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. (PubMed id 11435692)^{1, 2, 9} Bauer W.O.... Jakob F. (2001)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. (PubMed id 17154549)^{2, 9} Sengupta S....Binder L.I. (2006)
6. cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate? (PubMed id 10037494)^{1, 9} Huber G....Malherbe P. (1999)
7. Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of fro ntotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau. (PubMed id 20377816)^{1, 9} Yanagi K....Takeda M. (2009)
8. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. (PubMed id 17318184)^{2, 9} Bhutani N....Goldberg A.L. (2007)
9. Cobalt chloride-induced downregulation of puromycin-s ensitive aminopeptidase suppresses the migration and invasion of PC-3 cells. (PubMed id 19494703)^{1, 9} Lee S.H. and Kim H.G. (2009)
10. Cytosolic aminopeptidases influence MHC class I-media ted antigen presentation in an allele-dependent manner. (PubMed id 19917696)^{2, 9} Kim E....Ahn K. (2009)
11. Analysis of conserved residues of the human puromycin-sensitive aminopeptidase. (PubMed id 14706550)^{1, 9} Thompson M.W. and Hersh L.B. (2003)
12. Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. (PubMed id 12729622)^{2, 9} Thompson M.W....Hersh L.B. (2003)
13. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
14. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
15. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
16. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
17. A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)¹ Impens F....Gevaert K. (2012)
18. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
19. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
20. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
21. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)¹ Berndt J.D....Moon R.T. (2011)
22. Puromycin-sensitive aminopeptidase (PSA/NPEPPS) imped es development of neuropathology in hPSA/TAU(P301L) double-transgenic mice. (PubMed id 21320871)¹ Kudo L.C....Karsten S.L. (2011)
23. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)
24. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)¹ Greco T.M....Cristea I.M. (2011)
25. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
26. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)¹ Teixeira F.R.... Gomes M.D. (2010)
27. Puromycin-sensitive aminopeptidase protects against a ggregation-prone proteins via autophagy. (PubMed id 20829225)¹ Menzies F.M....Rubinsztein D.C. (2010)
28. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
29. Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
30. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
31. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)¹ Meierhofer D.... Kaiser P. (2008)
32. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
33. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
34. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
35. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
36. Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain. (PubMed id 10582526)¹ de Gandarias J.M....Casis L. (1999)
37. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
38. Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. (PubMed id 7592939)¹ Constam D.B....Fontana A. (1995)
39. Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections. (PubMed id 8082751)¹ Cussenot O....Le Duc A. (1994)
40. Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases. (PubMed id 3171591)¹ McLellan S....Hersh L.B. (1988)
41. (PubMed id 10978616)² 
42. (PubMed id 11062501)² 
43. Puromycin-sensitive aminopeptidase: an antiviral prod rug activating enzyme. (PubMed id 19969024)⁹ Tehler U....Amidon G.L. (2010)
44. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. (PubMed id 16950154)⁹ Karsten S.L....Jackson G.R. (2006)
45. Changes in puromycin-sensitive aminopeptidases in postmortem schizophrenic brain regions. (PubMed id 8845744)⁹ Hui M....Hui K.S. (1995)
46. Three-dimensional QSAR of HPPD inhibitors, PSA inhibitors, and anxiolytic agents: effect of tautomerism on the CoMFA models. (PubMed id 17418602)⁹ Zou J.W....Yu Q.S. (2007)
47. Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. (PubMed id 12467622)⁹ Kakuta H....Hashimoto Y. (2003)
48. Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: identification of the target molecule and a structure-activity relationship study. (PubMed id 11197332)⁹ Komoda M....Hashimoto Y. (2001)
49. Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M. (PubMed id 7790884)⁹ Safavi A. and Hersh L.B. (1995)
50. Aminopeptidase activity in the postmortem brain of human heroin addicts. (PubMed id 15670637)⁹ Larrinaga G....Irazusta J. (2005)
51. [Preparation of novel specific aminopeptidase inhibitors with a cyclic imide skeleton] (PubMed id 11082703)⁹ Takahashi H....Hashimoto Y. (2000)
52. Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration. (PubMed id 17476590)⁹ Hui K.S. (2007)
53. Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain. (PubMed id 15936526)⁹ Larrinaga G....Gil J. (2005)
54. Revisiting the function of PSA-NCAM in the nervous system. (PubMed id 11831554)⁹ Durbec P. and Cremer H. (2001)
55. A novel mammalian high-molecular-weight aminopeptidase. (PubMed id 9244402)⁹ Erbeznik H. and Hersh L.B. (1997)
56. Expression of immunoreactive polysialylated neural cell adhesion molecule in the suprachiasmatic nucleus. (PubMed id 8090287)⁹ Glass J.D....Watanabe M. (1994)
57. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. (PubMed id 16985214)⁹ Varona A....Larrinaga G. (2007)
58. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. (PubMed id 14734113)⁹ Kloetzel P.M. and Ossendorp F. (2004)
59. A recyclable assay to analyze the NH(2)-terminal trimming of antigenic peptide precursors. (PubMed id 12356466)⁹ Burri L....Levy F. (2002)
60. Angiogenesis in prostate cancer: its role in disease progression and possible therapeutic approaches. (PubMed id 12431818)⁹ van Moorselaar R.J. and Voest E.E. (2002)
61. Beyond the proteasome: trimming, degradation and generation of MHC class I ligands by auxiliary proteases. (PubMed id 12200051)⁹ Saveanu L....van Endert P. (2002)
62. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. (PubMed id 11819115)⁹ Schulz C....Fuller M.T. (2001)
63. Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. (PubMed id 19373777)⁹ PAcrez I....Larrinaga G. (2009)
64. Re-evaluating the generation of a 'proteasome-independent' MHC class I-restricted CD8 T cell epitope. (PubMed id 16455981)⁹ Wherry E.J....Eisenlohr L.C. (2006)
65. Identification of differentially expressed genes in human pineal parenchymal tumors by microarray analysis. (PubMed id 15627204)⁹ Champier J....Fevre-Montange M. (2005)
66. Matrix metalloproteinases as diagnostic (MMP-13) and prognostic (MMP-2, MMP-9) markers of prostate cancer. (PubMed id 15517230)⁹ Morgia G....Mazzarino M.C. (2005)
67. Processing of antigenic peptides by aminopeptidases. (PubMed id 15187416)⁹ Hattori A. and Tsujimoto M. (2004)

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