Aliases for NPEPPS Gene
Aliases for NPEPPS Gene
External Ids for NPEPPS Gene
- HGNC: 7900
- Entrez Gene: 9520
- Ensembl: ENSG00000141279
- OMIM: 606793
- UniProtKB: P55786
Previous GeneCards Identifiers for NPEPPS Gene
- GC17P035973
- GC17P048089
- GC17P045950
- GC17P046083
- GC17P042963
- GC17P045608
- GC17P041029
Summaries for NPEPPS Gene
-
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for NPEPPS Gene
NPEPPS (Aminopeptidase Puromycin Sensitive) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ENPEP.
UniProtKB/Swiss-Prot for NPEPPS Gene
-
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPEPPS Gene
Genomics for NPEPPS Gene
Regulatory Elements for NPEPPS Gene
Enhancers for NPEPPS Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NPEPPS on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NPEPPS Gene
- Chromosome:
- 17
- Start:
- 47,522,942 bp from pter
- End:
- 47,623,276 bp from pter
- Size:
- 100,335 bases
- Orientation:
- Plus strand
Genomic View for NPEPPS Gene
Genes around NPEPPS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
NPEPPS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NPEPPS Gene
Proteins for NPEPPS Gene
-
Protein details for NPEPPS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55786-PSA_HUMAN
- Recommended name:
- Puromycin-sensitive aminopeptidase
- Protein Accession:
- P55786
- B7Z463
- Q6P145
- Q9NP16
- Q9UEM2
Protein attributes for NPEPPS Gene
- Size:
- 919 amino acids
- Molecular mass:
- 103276 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=AAH65294.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for NPEPPS Gene
Selected DME Specific Peptides for NPEPPS Gene
- P55786:
-
- GAMENWG
- STYLVAF
- WFGNLVT
- HELAHQWFG
- WLNEGFA
- KGASVIRM
Post-translational modifications for NPEPPS Gene
Other Protein References for NPEPPS Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NPEPPS
- Novus Biologicals Antibodies for NPEPPS
-
Abcam antibodies for NPEPPS
-
Cloud-Clone Corp. Antibodies for NPEPPS
- Invitrogen Antibodies for NPEPPS
- antibodies-online Antibodies for NPEPPS: See all 66
- GeneTex NPEPPS antibody for NPEPPS
-
Santa Cruz Biotechnology (SCBT) Antibodies for NPEPPS
Protein Products
- R&D Systems Proteins and Enzymes for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
-
OriGene Purified Proteins for NPEPPS
- Search Origene for MassSpec and Protein Over-expression Lysates for NPEPPS
- Origene Custom Protein Services for NPEPPS
-
Cloud-Clone Corp. Proteins for NPEPPS
- antibodies-online Proteins for NPEPPS: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NPEPPS
-
Abcam proteins for NPEPPS
Domains & Families for NPEPPS Gene
Gene Families for NPEPPS Gene
- HGNC:
- IUPHAR :
Protein Domains for NPEPPS Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NPEPPS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55786- Family:
-
- Belongs to the peptidase M1 family.
Function for NPEPPS Gene
Molecular function for NPEPPS Gene
- GENATLAS Biochemistry:
- aminopeptidase puromycin sensitive,expressed in the brain (most abundant aminopeptidase),localized in cortical and cerebellar neurons,putatively contributing to the degradation of enkephalins
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.20 mM for Lys-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.25 mM for Leu-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.27 mM for Ala-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.80 mM for Met-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.47 mM for Pro-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.21 mM for Val-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=182 uM for Ala-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=189 uM for Met-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=220 uM for Lys-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=91 uM for Leu-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=167 uM for Phe-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; pH dependence: Optimum pH is 7.5. Stable from pH 5.0 to 8.0. {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; Temperature dependence: Stable up to 40 degrees Celsius. {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+).
- UniProtKB/Swiss-Prot Function:
- Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Enzyme Numbers (IUBMB) for NPEPPS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004177 | aminopeptidase activity | EXP | 9668046 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0008270 | zinc ion binding | IBA,IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for NPEPPS Gene
- MGI mutant phenotypes for NPEPPS:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NPEPPS:
Animal Models for NPEPPS Gene
- MGI Knock Outs for NPEPPS:
-
- Npepps tm1Klr
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NPEPPS
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
- Search ViGene Biosciences for NPEPPS
CRISPR Products
-
OriGene CRISPR knockouts for NPEPPS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- GenScript: Design CRISPR guide RNA sequences for NPEPPS
miRNA for NPEPPS Gene
- miRTarBase miRNAs that target NPEPPS
-
- hsa-mir-122-5p (MIRT023333)
- hsa-mir-484 (MIRT041818)
- hsa-mir-423-3p (MIRT042580)
- hsa-mir-320a (MIRT044392)
- hsa-mir-27b-3p (MIRT046171)
- hsa-mir-93-5p (MIRT048787)
- hsa-mir-27a-3p (MIRT116571)
- hsa-mir-491-3p (MIRT116575)
- hsa-mir-659-3p (MIRT287612)
- hsa-mir-873-5p (MIRT287613)
- hsa-mir-1277-5p (MIRT287614)
- hsa-mir-3942-3p (MIRT287615)
- hsa-mir-4424 (MIRT287616)
- hsa-mir-5100 (MIRT287618)
- hsa-mir-218-1-3p (MIRT472027)
- hsa-mir-4722-5p (MIRT472028)
- hsa-mir-1286 (MIRT472029)
- hsa-mir-3189-3p (MIRT472030)
- hsa-mir-10b-3p (MIRT472031)
- hsa-mir-141-5p (MIRT472032)
- hsa-mir-500a-5p (MIRT472033)
- hsa-mir-500b-5p (MIRT472034)
- hsa-mir-362-5p (MIRT472035)
- hsa-mir-212-5p (MIRT472036)
- hsa-mir-6807-5p (MIRT522249)
- hsa-mir-6862-3p (MIRT522250)
- hsa-mir-516a-5p (MIRT522251)
- hsa-mir-4267 (MIRT522252)
- hsa-mir-500b-3p (MIRT522253)
- hsa-mir-6739-5p (MIRT535636)
- hsa-mir-6733-5p (MIRT535637)
- hsa-mir-3153 (MIRT535638)
- hsa-mir-9500 (MIRT535639)
- hsa-mir-6822-5p (MIRT535640)
- hsa-mir-6750-5p (MIRT535641)
- hsa-mir-5584-5p (MIRT535642)
- hsa-mir-548m (MIRT535643)
miRNA Products
- Search ViGene Biosciences for NPEPPS
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NPEPPS
- Browse OriGene Inhibitory RNA Products For NPEPPS
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
Clone Products
-
OriGene ORF clones in human for NPEPPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPEPPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPEPPS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NPEPPS
-
ViGene Biosciences adenoviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPEPPS Gene
Localization for NPEPPS Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPEPPS Gene
- Cytoplasm, cytosol. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for NPEPPS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for NPEPPS Gene
4 Reactome pathways for NPEPPS Gene
Interacting Proteins for NPEPPS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006508 | proteolysis | IBA,IEA | -- |
| GO:0043171 | peptide catabolic process | IBA | -- |
| GO:0071456 | cellular response to hypoxia | IDA | 21056661 |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | IMP | 24270810 |
No data available for SIGNOR curated interactions for NPEPPS Gene
Drugs & Compounds for NPEPPS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CHR-2797 | Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NPEPPS Gene
mRNA/cDNA for NPEPPS Gene
- (5) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (558) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NPEPPS Gene
CRISPR Products
-
OriGene CRISPR knockouts for NPEPPS
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- GenScript: Design CRISPR guide RNA sequences for NPEPPS
miRNA Products
- Search ViGene Biosciences for NPEPPS
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NPEPPS
- Browse OriGene Inhibitory RNA Products For NPEPPS
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
Clone Products
-
OriGene ORF clones in human for NPEPPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NPEPPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPEPPS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 23 | ^ | 24a | · | 24b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: |
Expression for NPEPPS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPEPPS Gene
NURSA nuclear receptor signaling pathways regulating expression of NPEPPS Gene:
NPEPPSSOURCE GeneReport for Unigene cluster for NPEPPS Gene:
Hs.443837mRNA Expression by UniProt/SwissProt for NPEPPS Gene:
P55786-PSA_HUMAN
Tissue specificity:
Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).
Evidence on tissue expression from TISSUES for NPEPPS Gene
- Nervous system(5)
- Lung(4.6)
- Liver(4.5)
- Muscle(4.4)
- Kidney(3.4)
- Heart(2.8)
- Intestine(2.7)
- Blood(2.5)
- Eye(2.5)
- Skin(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for NPEPPS
-
OriGene qPCR primer pairs and template standards for NPEPPS
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPEPPS Gene
Orthologs for NPEPPS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NPEPPS 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| NPEPPS 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| NPEPPS 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Npepps 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Npepps 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| NPEPPS 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | npepps 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | npepps 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Psa 36 34 35 |
|
||
| CG11951 36 |
|
|
|||
| CG5849 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005728 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pam-1 35 34 |
|
OneToMany | |
| F49E8.3 36 |
|
|
|||
| Y67D8C.9 36 |
|
|
|||
| T07F10.1 36 |
|
|
|||
| R03G8.6 36 |
|
|
|||
| R03G8.4 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | APE2 34 35 |
|
||
| AAP1 35 37 |
|
ManyToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL127W 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C11033g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | APM1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0218200 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2808 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.5246 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.4333 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4553 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09228 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ape2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4583 34 |
|
- Species where no ortholog for NPEPPS was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for NPEPPS Gene
(8) SIMAP similar genes for NPEPPS Gene using alignment to 13 proteins:
Pseudogenes.org Pseudogenes for NPEPPS Gene
Variants for NPEPPS Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008167 | -- | 47,607,161(+) | CACTC(C/T)AGCCT | intron-variant | |
| rs1000013668 | -- | 47,599,684(+) | GAAGA(C/T)GACAG | reference, synonymous-codon | |
| rs1000087408 | -- | 47,616,531(+) | ATACA(A/G)AAATT | intron-variant | |
| rs1000096907 | -- | 47,556,741(+) | GCGGC(C/T)CAAGC | intron-variant | |
| rs1000163592 | -- | 47,543,213(+) | ACTTA(A/G)TGGCG | intron-variant |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.42;
27.93% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NPEPPS Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPEPPS Gene
Disorders for NPEPPS Gene
Relevant External Links for NPEPPS
No disorders were found for NPEPPS Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPEPPS Gene
Publications for NPEPPS Gene
- Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (PMID: 10329370) Thompson M.W. … Hersh L.B. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
- Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. (PMID: 9048733) Tobler A.R. … Fontana A. (J. Neurochem. 1997) 2 3 4 22 64
- Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. (PMID: 11435692) Bauer W.O. … Jakob F. (Cytogenet. Cell Genet. 2001) 3 4 22 64
- Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells. (PMID: 19494703) Lee S.H. … Kim H.G. (J. Microbiol. Biotechnol. 2009) 3 22 64
- Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner. (PMID: 19917696) Kim E. … Ahn K. (J. Immunol. 2009) 4 22 64
Products for NPEPPS Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NPEPPS
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NPEPPS
- Search Origene for MassSpec and Protein Over-expression Lysates for NPEPPS
- Origene Custom Protein Services for NPEPPS
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NPEPPS
- Browse OriGene Inhibitory RNA Products For NPEPPS
- OriGene qPCR primer pairs and template standards for NPEPPS
- OriGene qPCR primer pairs for NPEPPS
- OriGene CRISPR knockouts for NPEPPS
- OriGene ORF clones in human for NPEPPS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NPEPPS
- GenScript: Next-day shipping cDNA ORF clone for NPEPPS in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NPEPPS
- GenScript Custom Assay Services for NPEPPS
- GenScript Custom overexpressing Cell Line Services for NPEPPS
- GenScript: Design CRISPR guide RNA sequences for NPEPPS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NPEPPS
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for NPEPPS
- Novus Biologicals proteins and lysates for NPEPPS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NPEPPS
- Abcam proteins for NPEPPS
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for NPEPPS
- Cloud-Clone Corp. Proteins for NPEPPS
- Cloud-Clone Corp Assay Kits for NPEPPS
- Invitrogen Antibodies for NPEPPS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for NPEPPS: See all 66
- antibodies-online Kits for NPEPPS: See all 3
- antibodies-online Proteins for NPEPPS: See all 11
- Search antibodies-online for peptides
- GeneTex NPEPPS antibody for NPEPPS
- Search GeneTex for Proteins for NPEPPS
- ViGene Biosciences adenoviral particle packaged cDNA for NPEPPS gene
- ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
- Search ViGene Biosciences for NPEPPS
- Santa Cruz Biotechnology (SCBT) Antibodies for NPEPPS
- Search Santa Cruz Biotechnology (SCBT) for NPEPPS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- Horizon Cell Lines for NPEPPS
- Cyagen custom Knockout/knockin (KOKI) mouse models for NPEPPS
- VectorBuilder custom plasmid, inducible vectors for NPEPPS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NPEPPS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NPEPPS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer