Aliases for NPEPPS Gene
Aliases for NPEPPS Gene
External Ids for NPEPPS Gene
- HGNC: 7900
- Entrez Gene: 9520
- Ensembl: ENSG00000141279
- OMIM: 606793
- UniProtKB: P55786
Previous GeneCards Identifiers for NPEPPS Gene
- GC17P035973
- GC17P048089
- GC17P045950
- GC17P046083
- GC17P042963
- GC17P045608
- GC17P041029
Summaries for NPEPPS Gene
-
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for NPEPPS Gene
NPEPPS (Aminopeptidase Puromycin Sensitive) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ENPEP.
UniProtKB/Swiss-Prot for NPEPPS Gene
-
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Additional gene information for NPEPPS Gene
- Monarch Initiative
- Search for NPEPPS at DataMed
- Search for NPEPPS at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPEPPS Gene
Genomics for NPEPPS Gene
GeneHancer (GH) Regulatory Elements for NPEPPS Gene
Promoters and enhancers for NPEPPS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NPEPPS on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NPEPPS Gene
Genomic Locations for NPEPPS Gene
- chr17:47,522,942-47,623,276
- (GRCh38/hg38)
- Size:
- 100,335 bases
- Orientation:
- Plus strand
- chr17:45,600,308-45,700,642
- (GRCh37/hg19)
Genomic View for NPEPPS Gene
Genes around NPEPPS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
NPEPPS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NPEPPS Gene
Proteins for NPEPPS Gene
-
Protein details for NPEPPS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55786-PSA_HUMAN
- Recommended name:
- Puromycin-sensitive aminopeptidase
- Protein Accession:
- P55786
- B7Z463
- Q6P145
- Q9NP16
- Q9UEM2
Protein attributes for NPEPPS Gene
- Size:
- 919 amino acids
- Molecular mass:
- 103276 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=AAH65294.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA68964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for NPEPPS Gene
Selected DME Specific Peptides for NPEPPS Gene
- P55786:
-
- GAMENWG
- STYLVAF
- WFGNLVT
- HELAHQWFG
- WLNEGFA
- KGASVIRM
Post-translational modifications for NPEPPS Gene
No Post-translational modifications
Other Protein References for NPEPPS Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NPEPPS
- Novus Biologicals Antibodies for NPEPPS
-
Abcam antibodies for NPEPPS
-
Cloud-Clone Corp. Antibodies for NPEPPS
- Invitrogen Antibodies for NPEPPS
- antibodies-online: Search results for 71 available NPEPPS Antibodies ranked by validation data
- Compare Top NPEPPS Antibodies
-
Quality Products:
- ABIN2856994
- ABIN1176248
- ABIN1860331
- ABIN1176245
- ABIN932208
- ABIN2466539
- ABIN303887
- ABIN408680
- ABIN238593
- ABIN453303
- ABIN2856994
- ABIN1176248
- ABIN1860331
- ABIN1176245
- ABIN932208
- ABIN2466539
- ABIN303887
- ABIN408680
- ABIN238593
- ABIN453303
- ABIN2856994
- ABIN1176248
- ABIN1860331
- ABIN1176245
- ABIN932208
- ABIN2466539
- ABIN303887
- ABIN408680
- ABIN238593
- ABIN453303
- GeneTex NPEPPS antibody for NPEPPS
-
Santa Cruz Biotechnology (SCBT) Antibodies for NPEPPS
Protein Products
- R&D Systems Proteins and Enzymes for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
-
OriGene Purified Proteins for NPEPPS
- Search Origene for MassSpec and Protein Over-expression Lysates for NPEPPS
- Origene Custom Protein Services for NPEPPS
-
Cloud-Clone Corp. Proteins for NPEPPS
- Search GeneTex for Proteins for NPEPPS
-
Abcam proteins for NPEPPS
Assay Products
-
Cloud-Clone Corp. Assay Kits for NPEPPS
Domains & Families for NPEPPS Gene
Gene Families for NPEPPS Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NPEPPS Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NPEPPS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55786- Family:
-
- Belongs to the peptidase M1 family.
Function for NPEPPS Gene
Molecular function for NPEPPS Gene
- GENATLAS Biochemistry:
- aminopeptidase puromycin sensitive,expressed in the brain (most abundant aminopeptidase),localized in cortical and cerebellar neurons,putatively contributing to the degradation of enkephalins
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=2.20 mM for Lys-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.25 mM for Leu-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.27 mM for Ala-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.80 mM for Met-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.47 mM for Pro-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=0.21 mM for Val-p-NA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=182 uM for Ala-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=189 uM for Met-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=220 uM for Lys-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=91 uM for Leu-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; KM=167 uM for Phe-MCA {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; pH dependence: Optimum pH is 7.5. Stable from pH 5.0 to 8.0. {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549}; Temperature dependence: Stable up to 40 degrees Celsius. {ECO:0000269 PubMed:10978616, ECO:0000269 PubMed:17154549};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+).
- UniProtKB/Swiss-Prot Function:
- Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Enzyme Numbers (IUBMB) for NPEPPS Gene
Phenotypes From GWAS Catalog for NPEPPS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004177 | aminopeptidase activity | EXP | 9668046 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0008270 | zinc ion binding | IBA,IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for NPEPPS Gene
- MGI mutant phenotypes for NPEPPS:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NPEPPS:
Animal Models for NPEPPS Gene
- MGI Knock Outs for NPEPPS:
-
- Npepps tm1Klr
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
- Search ViGene Biosciences for NPEPPS
CRISPR Products
-
OriGene CRISPR knockouts for NPEPPS
- genomics-online: gRNA clones - Search results for 29 available NPEPPS gene related products
- Overview of 29 available NPEPPS gene related products
- Applied Biological Materials CRISPR for NPEPPS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- GenScript: Design CRISPR guide RNA sequences for NPEPPS
miRNA for NPEPPS Gene
- miRTarBase miRNAs that target NPEPPS
-
- hsa-mir-122-5p (MIRT023333)
- hsa-mir-484 (MIRT041818)
- hsa-mir-423-3p (MIRT042580)
- hsa-mir-320a (MIRT044392)
- hsa-mir-27b-3p (MIRT046171)
- hsa-mir-93-5p (MIRT048787)
- hsa-mir-27a-3p (MIRT116571)
- hsa-mir-491-3p (MIRT116575)
- hsa-mir-659-3p (MIRT287612)
- hsa-mir-873-5p (MIRT287613)
- hsa-mir-1277-5p (MIRT287614)
- hsa-mir-3942-3p (MIRT287615)
- hsa-mir-4424 (MIRT287616)
- hsa-mir-5100 (MIRT287618)
- hsa-mir-218-1-3p (MIRT472027)
- hsa-mir-4722-5p (MIRT472028)
- hsa-mir-1286 (MIRT472029)
- hsa-mir-3189-3p (MIRT472030)
- hsa-mir-10b-3p (MIRT472031)
- hsa-mir-141-5p (MIRT472032)
- hsa-mir-500a-5p (MIRT472033)
- hsa-mir-500b-5p (MIRT472034)
- hsa-mir-362-5p (MIRT472035)
- hsa-mir-212-5p (MIRT472036)
- hsa-mir-6807-5p (MIRT522249)
- hsa-mir-6862-3p (MIRT522250)
- hsa-mir-516a-5p (MIRT522251)
- hsa-mir-4267 (MIRT522252)
- hsa-mir-500b-3p (MIRT522253)
- hsa-mir-6739-5p (MIRT535636)
- hsa-mir-6733-5p (MIRT535637)
- hsa-mir-3153 (MIRT535638)
- hsa-mir-9500 (MIRT535639)
- hsa-mir-6822-5p (MIRT535640)
- hsa-mir-6750-5p (MIRT535641)
- hsa-mir-5584-5p (MIRT535642)
- hsa-mir-548m (MIRT535643)
miRNA Products
- Search ViGene Biosciences for NPEPPS
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NPEPPS
- Browse OriGene Inhibitory RNA Products For NPEPPS
- genomics-online: shRNA clones - Search results for 29 available NPEPPS gene related products
- Overview of 29 available NPEPPS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for NPEPPS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NPEPPS
-
ViGene Biosciences adenoviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPEPPS Gene
Localization for NPEPPS Gene
Subcellular locations from UniProtKB/Swiss-Prot for NPEPPS Gene
- Cytoplasm, cytosol. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA,IDA | 19056867 |
Pathways & Interactions for NPEPPS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for NPEPPS Gene
4 Reactome pathways for NPEPPS Gene
Interacting Proteins for NPEPPS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006508 | proteolysis | IBA,IEA | -- |
| GO:0043171 | peptide catabolic process | IBA | -- |
| GO:0071456 | cellular response to hypoxia | IDA | 21056661 |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | IMP | 24270810 |
No data available for SIGNOR curated interactions for NPEPPS Gene
Drugs & Compounds for NPEPPS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Tosedostat | Investigational | Pharma | Target | Others | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for NPEPPS Gene
mRNA/cDNA for NPEPPS Gene
- (5) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (558) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NPEPPS Gene
CRISPR Products
-
OriGene CRISPR knockouts for NPEPPS
- genomics-online: gRNA clones - Search results for 29 available NPEPPS gene related products
- Overview of 29 available NPEPPS gene related products
- Applied Biological Materials CRISPR for NPEPPS
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- GenScript: Design CRISPR guide RNA sequences for NPEPPS
miRNA Products
- Search ViGene Biosciences for NPEPPS
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NPEPPS
- Browse OriGene Inhibitory RNA Products For NPEPPS
- genomics-online: shRNA clones - Search results for 29 available NPEPPS gene related products
- Overview of 29 available NPEPPS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for NPEPPS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 23 | ^ | 24a | · | 24b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: |
Expression for NPEPPS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPEPPS Gene
NURSA nuclear receptor signaling pathways regulating expression of NPEPPS Gene:
NPEPPSSOURCE GeneReport for Unigene cluster for NPEPPS Gene:
Hs.443837mRNA Expression by UniProt/SwissProt for NPEPPS Gene:
P55786-PSA_HUMAN
Tissue specificity:
Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).
Evidence on tissue expression from TISSUES for NPEPPS Gene
- Nervous system(5)
- Lung(4.6)
- Liver(4.5)
- Muscle(4.4)
- Kidney(3.4)
- Heart(2.8)
- Intestine(2.7)
- Blood(2.6)
- Eye(2.5)
- Skin(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for NPEPPS
-
OriGene qPCR primer pairs and template standards for NPEPPS
- genomics-online: primer clones - Search results for 29 available NPEPPS gene related products
- Overview of 29 available NPEPPS gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPEPPS Gene
Orthologs for NPEPPS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NPEPPS 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| NPEPPS 33 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| NPEPPS 33 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Npepps 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Npepps 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| NPEPPS 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | npepps 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | npepps 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Psa 35 33 34 |
|
||
| CG11951 35 |
|
|
|||
| CG5849 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005728 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pam-1 33 34 |
|
||
| F49E8.3 35 |
|
|
|||
| Y67D8C.9 35 |
|
|
|||
| T07F10.1 35 |
|
|
|||
| R03G8.6 35 |
|
|
|||
| R03G8.4 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | APE2 33 34 |
|
||
| AAP1 34 36 |
|
ManyToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL127W 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C11033g 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | APM1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0218200 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2808 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.5246 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.4333 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4553 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09228 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ape2 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4583 33 |
|
- Species where no ortholog for NPEPPS was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for NPEPPS Gene
(8) SIMAP similar genes for NPEPPS Gene using alignment to 13 proteins:
Pseudogenes.org Pseudogenes for NPEPPS Gene
Variants for NPEPPS Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008167 | -- | 47,607,161(+) | C/T | intron_variant | |
| rs1000013668 | -- | 47,599,684(+) | T/C | coding_sequence_variant, synonymous_variant | |
| rs1000087408 | -- | 47,616,531(+) | A/G | intron_variant | |
| rs1000096907 | -- | 47,556,741(+) | T/C | intron_variant | |
| rs1000163592 | -- | 47,543,213(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.42;
27.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NPEPPS Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPEPPS Gene
Disorders for NPEPPS Gene
Additional Disease Information for NPEPPS
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NPEPPS Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPEPPS Gene
Publications for NPEPPS Gene
- Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. (PMID: 10329370) Thompson MW … Hersh LB (Biochemical and biophysical research communications 1999) 2 3 4 22 58
- Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. (PMID: 9048733) Tobler AR … Fontana A (Journal of neurochemistry 1997) 2 3 4 22 58
- Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. (PMID: 11435692) Bauer WO … Jakob F (Cytogenetics and cell genetics 2001) 3 4 22 58
- Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells. (PMID: 19494703) Lee SH … Kim HG (Journal of microbiology and biotechnology 2009) 3 22 58
- Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau. (PMID: 20377816) Yanagi K … Takeda M (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2009) 3 22 58
Products for NPEPPS Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for NPEPPS (Puromycin-sensitive aminopeptidase/NPEPPS)
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for NPEPPS
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for NPEPPS in any vector
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- Find your target
- Browse Primary Antibodies
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- Cloud-Clone Corp. Antibodies for NPEPPS
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- Browse Knockouts at Cloud-Clone Corp.
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- Invitrogen Antibodies for NPEPPS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 71 available Prostate Specific Antigen Antibodies ranked by validation data
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- ABIN2466539
- ABIN932208
- ABIN1176245
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- ABIN1176248
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- antibodies-online: Search results for 8 available Prostate Specific Antigen Elisa Kits ranked by validation data
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- antibodies-online: Search results for 9 available Prostate Specific Antigen Proteins ranked by validation data
- Compare Top Prostate Specific Antigen Proteins
- GeneTex NPEPPS antibody for NPEPPS
- Search GeneTex for Proteins for NPEPPS
- ViGene Biosciences adenoviral particle packaged cDNA for NPEPPS gene
- ViGene Biosciences lentiviral particle packaged cDNA for NPEPPS gene
- ViGene Biosciences ready-to-package AAV shRNAs for NPEPPS gene
- Search ViGene Biosciences for NPEPPS
- Santa Cruz Biotechnology (SCBT) Antibodies for NPEPPS
- Search Santa Cruz Biotechnology (SCBT) for NPEPPS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NPEPPS
- Horizon Cell Lines for NPEPPS
- genomics-online: cdna clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
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- Overview of 29 available Prostate Specific Antigen gene related products
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- genomics-online: primer clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
- genomics-online: shRNA clones - Search results for 29 available Prostate Specific Antigen gene related products
- Overview of 29 available Prostate Specific Antigen gene related products
Sources for NPEPPS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew