NPEPL1 Gene
protein-coding GIFtS: 48
GCID: GC20P057267
|
|
aminopeptidase-like 1
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Aliases
for NPEPL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aminopeptidase-Like 11 2 3 | | KIAA19743 | | BA261P9.21 | | R5 | | FLJ115831 | | EC 3.4.118 | | Probable Aminopeptidase NPEPL12 | | EC 3.4.11.18 | | EC 3.4.11.-3 | | |
Export aliases for NPEPL1 gene to outside databasesPrevious GC identifers: GC20P056995 GC20P057905 GC20P057952 GC20P057953 GC20P056700 GC20P054059 |
Summaries
for NPEPL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PEPL1_HUMAN, Q8NDH3Function: Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
|
Genomic Views
for NPEPL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPEPL1 gene promoter:
c-Fos NF-1 AP-1 FOXO3 FOXO3b CREB POU2F1 POU2F1a Chx10 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPEPL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPEPL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.32NPEPL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P057267: view genomic region
(about GC identifiers)
Start:
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57,264,187 bp from pter |
End:
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57,294,294 bp from pter |
Size:
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30,108 bases |
Orientation:
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plus strand |
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Proteins
for NPEPL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PEPL1_HUMAN, Q8NDH3 (See
protein sequence)Recommended Name: Probable aminopeptidase NPEPL1 Size: 523 amino acids; 55861 Da
Cofactor: Zinc or manganese
Sequence caution: Sequence=AK307771; Type=Frameshift; Positions=35; Sequence=BAB13861.1; Type=Frameshift; Positions=71;
Secondary accessions: A6NGZ0 B4DMW7 B7ZBN0 E9PN47 G5EA34 Q53G37 Q5W083 Q8TF28 Q8WUI2 Q9H1T6 Q9HAI5Alternative splicing: 5 isoforms: Q8NDH3-1 Q8NDH3-2 Q8NDH3-3 Q8NDH3-4 Q8NDH3-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NPEPL1: NX_Q8NDH3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDH3
2 DME Specific Peptides for NPEPL1 (Q8NDH3)
NPEPL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001191801.1 NP_001191802.1 NP_078939.3
ENSEMBL proteins: ENSP00000434810 ENSP00000437112 ENSP00000348395 ENSP00000436265
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NPEPL1 for ontologies About GeneDecksing
NPEPL1 Antibody Products:
Assay Products for NPEPL1: |
Protein
Domains /
Families
for NPEPL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPEPL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NDH3ProtoNet protein and cluster: Q8NDH3 2 Blocks protein families: IPB000408 Regulator of chromosome condensation IPB000819 Cytosol aminopeptidase
UniProtKB/Swiss-Prot: PEPL1_HUMAN, Q8NDH3Similarity: Belongs to the peptidase M17 family |
Function
for NPEPL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PEPL1_HUMAN, Q8NDH3Function: Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptidesEnzyme Numbers (IUBMB): EC 3.4.11.-1 EC 3.4.11.12 EC 3.4.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPEPL1 (NM_018226) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPEPL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPL1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004177 | aminopeptidase activity |
IEA | -- | | GO:0008235 | metalloexopeptidase activity |
IEA | -- | | GO:0030145 | manganese ion binding |
IEA | -- |
NPEPL1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for NPEPL1:
|
Pathways & Interactions
for NPEPL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPEPL1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for NPEPL1 (Q8NDH33 ENSP000003483954) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
NPEPL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NPEPL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPEPL1
1 HMDB Compound for NPEPL1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Manganese | manganese | 7439-96-5 | -- |
Search CenterWatch for drugs/clinical trials and news about NPEPL1 / PEPL1
|
Transcripts
for NPEPL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPEPL1 gene (3 alternative transcripts): NM_001204872.1 NM_001204873.1 NM_024663.3 Unigene Cluster for NPEPL1: Aminopeptidase-like 1 Hs.654868 [show with all ESTs]Unigene Representative Sequence: NR_0379459 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525967 ENST00000525817 ENST00000356091 ENST00000529976(uc002xzp.3)
ENST00000527587(uc010zzr.2 uc010gjo.2 uc010zzs.1) ENST00000533788
ENST00000527081 ENST00000525068 ENST00000532531
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPEPL1 (NM_018226) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPEPL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPL1 |
Additional cDNA sequence: AK021645.1 AK096873.1 AK124479.1 AK126390.1 AK223094.1 AK297667.1 AK307771.1 AK315684.1 BC020507.1 BC068074.1 NR_037945.1 16 DOTS entries: DT.95173595 DT.101979526 DT.95173597 DT.91871691 DT.100775145 DT.95173596 DT.120836141 DT.433571 DT.100775146 DT.412976 DT.120836094 DT.100810187 DT.102822900 DT.95092713 DT.95173599 DT.97814099 24/484 AceView cDNA sequences (see all 484): BM993587 AV728943 NM_003763 AW301582 CK824087 AI288570 CR607400 AI423904 CB127946 BG113954 AA167528 AW874573 AA682368 AI890882 CR617956 AL047428 AW027820 BM718417 AW262844 NM_024663 BQ723000 AI040458 BF871535 W42622
GeneLoc Exon Structure
|
Expression
for NPEPL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPEPL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTCGCCTG
About this image
See NPEPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPEPL1
SOURCE GeneReport for Unigene cluster: Hs.654868
UniProtKB/Swiss-Prot: PEPL1_HUMAN, Q8NDH3Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for NPEPL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPEPL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPEPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPL1 |
Orthologs
for NPEPL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for NPEPL1 gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for NPEPL1 (if available)
TreeFam Gene Tree for NPEPL1 (if available) |
Paralogs
for NPEPL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NPEPL1 gene
- LAP32
NPEPL1 for paralogs About GeneDecksing
|
Genomic Variants
for NPEPL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPEPL1 (57264187 - 57294294 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NPEPL1
1 Indel: 103003 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPEPL1 |
|
Disorders
/ Diseases
for NPEPL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPEPL1 for disorders About GeneDecksing
OMIM gene information: 605287
OMIM disorders: --
2  diseases for NPEPL1: About MalaCardstuberculosis mycobacterium tuberculosis
Export disorders for NPEPL1 gene to outside databases
|
Publications
for NPEPL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPEPL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NPEPL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for NPEPL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPEPL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPEPL1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NPEPL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPEPL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPEPL1 gene:
Search GeneIP for patents involving NPEPL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPEPL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPEPL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPEPL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPEPL1 | | | OriGene Protein Over-expression Lysate for NPEPL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPEPL1 | | OriGene 3'-UTR Clone for NPEPL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPEPL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NPEPL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPEPL1 | | OriGene Custom Protein Services for NPEPL1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPEPL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPEPL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPEPL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPEPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPEPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPEPL1 |
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 |  |  |  | |
| | | | Search Tocris compounds for NPEPL1 |
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 | | | NPEPL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPEPL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NPEPL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPEPL1 |
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