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Aliases for NPEPL1 Gene

Aliases for NPEPL1 Gene

  • Aminopeptidase-Like 1 2 3 4
  • Probable Aminopeptidase NPEPL1 3
  • EC 63
  • EC 3.4.11.- 4
  • BA261P9.2 3
  • EC 3.4.11 63
  • KIAA1974 4
  • R 6

External Ids for NPEPL1 Gene

Previous GeneCards Identifiers for NPEPL1 Gene

  • GC20P056995
  • GC20P057905
  • GC20P057952
  • GC20P057953
  • GC20P056700
  • GC20P057267
  • GC20P054059

Summaries for NPEPL1 Gene

GeneCards Summary for NPEPL1 Gene

NPEPL1 (Aminopeptidase-Like 1) is a Protein Coding gene. GO annotations related to this gene include manganese ion binding and metalloexopeptidase activity. An important paralog of this gene is LAP3.

UniProtKB/Swiss-Prot for NPEPL1 Gene

  • Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPEPL1 Gene

Genomics for NPEPL1 Gene

Regulatory Elements for NPEPL1 Gene

Genomic Location for NPEPL1 Gene

58,689,131 bp from pter
58,719,238 bp from pter
30,108 bases
Plus strand

Genomic View for NPEPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPEPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPEPL1 Gene

Proteins for NPEPL1 Gene

  • Protein details for NPEPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable aminopeptidase NPEPL1
    Protein Accession:
    Secondary Accessions:
    • A6NGZ0
    • B4DMW7
    • B7ZBN0
    • E9PN47
    • G5EA34
    • Q53G37
    • Q5W083
    • Q8TF28
    • Q8WUI2
    • Q9H1T6
    • Q9HAI5

    Protein attributes for NPEPL1 Gene

    523 amino acids
    Molecular mass:
    55861 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    • Sequence=AK307771; Type=Frameshift; Positions=35; Evidence={ECO:0000305}; Sequence=BAB13861.1; Type=Frameshift; Positions=71; Evidence={ECO:0000305};

    Alternative splice isoforms for NPEPL1 Gene


neXtProt entry for NPEPL1 Gene

Proteomics data for NPEPL1 Gene at MOPED

Selected DME Specific Peptides for NPEPL1 Gene

Post-translational modifications for NPEPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPEPL1 Gene

Antibody Products

Domains for NPEPL1 Gene

Gene Families for NPEPL1 Gene

Suggested Antigen Peptide Sequences for NPEPL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NDH3
  • Belongs to the peptidase M17 family.
genes like me logo Genes that share domains with NPEPL1: view

Function for NPEPL1 Gene

Molecular function for NPEPL1 Gene

UniProtKB/Swiss-Prot Function:
Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

Enzyme Numbers (IUBMB) for NPEPL1 Gene

Gene Ontology (GO) - Molecular Function for NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008235 metalloexopeptidase activity IEA --
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with NPEPL1: view
genes like me logo Genes that share phenotypes with NPEPL1: view

Animal Model Products

miRNA for NPEPL1 Gene

miRTarBase miRNAs that target NPEPL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPEPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NPEPL1 Gene

Localization for NPEPL1 Gene

Subcellular locations from

Jensen Localization Image for NPEPL1 Gene COMPARTMENTS Subcellular localization image for NPEPL1 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NPEPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NPEPL1 Gene

Pathways for NPEPL1 Gene

SuperPathways for NPEPL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NPEPL1: view

No data available for Pathways by source for NPEPL1 Gene

Compounds for NPEPL1 Gene

(1) HMDB Compounds for NPEPL1 Gene

Compound Synonyms Cas Number PubMed IDs
  • manganese
genes like me logo Genes that share compounds with NPEPL1: view

Transcripts for NPEPL1 Gene

Unigene Clusters for NPEPL1 Gene

Aminopeptidase-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPEPL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPEPL1 Gene

No ASD Table

Relevant External Links for NPEPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPEPL1 Gene

mRNA expression in normal human tissues for NPEPL1 Gene

Protein differential expression in normal tissues for NPEPL1 Gene

This gene is overexpressed in Uterus (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NPEPL1 Gene

SOURCE GeneReport for Unigene cluster for NPEPL1 Gene Hs.654868

mRNA Expression by UniProt/SwissProt for NPEPL1 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with NPEPL1: view

Expression partners for NPEPL1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NPEPL1 Gene

Orthologs for NPEPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPEPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPEPL1 35
  • 89.67 (n)
  • 94.84 (a)
  • 94 (a)
(Canis familiaris)
Mammalia NPEPL1 35
  • 89.17 (n)
  • 94.05 (a)
  • 94 (a)
(Mus musculus)
Mammalia Npepl1 35
  • 87.83 (n)
  • 94.84 (a)
Npepl1 16
Npepl1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Npepl1 35
  • 88 (n)
  • 94.65 (a)
(Monodelphis domestica)
Mammalia NPEPL1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia NPEPL1 36
  • 87 (a)
(Pan troglodytes)
Mammalia NPEPL1 36
  • 99 (a)
(Gallus gallus)
Aves NPEPL1 35
  • 76.29 (n)
  • 87.76 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia NPEPL1 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26107 35
(Danio rerio)
Actinopterygii npepl1 35
  • 73.68 (n)
  • 81.26 (a)
wufi27h09 35
npepl1 36
  • 81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10747 35
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD41548 37
  • 65 (a)
grsm 35
  • 62.76 (n)
  • 64.65 (a)
grsm 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007809 35
  • 62.58 (n)
  • 63.39 (a)
(Caenorhabditis elegans)
Secernentea lap-1 37
  • 49 (a)
lap-1 35
  • 50.83 (n)
  • 48.22 (a)
lap-1 36
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14240 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for NPEPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NPEPL1 Gene

Gene Tree for NPEPL1 (if available)
Gene Tree for NPEPL1 (if available)

Paralogs for NPEPL1 Gene

Paralogs for NPEPL1 Gene

genes like me logo Genes that share paralogs with NPEPL1: view

Variants for NPEPL1 Gene

Sequence variations from dbSNP and Humsavar for NPEPL1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_059756 -
VAR_059757 -

Structural Variations from Database of Genomic Variants (DGV) for NPEPL1 Gene

Variant ID Type Subtype PubMed ID
nsv828761 CNV Loss 20364138
nsv912963 CNV Gain 21882294
esv2558295 CNV Insertion 19546169
esv1198718 CNV Insertion 17803354
nsv513552 CNV Insertion 21212237
nsv828762 CNV Loss 20364138
esv2665738 CNV Deletion 23128226

Relevant External Links for NPEPL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPEPL1 Gene

Disorders for NPEPL1 Gene

No disorders were found for NPEPL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NPEPL1 Gene

Publications for NPEPL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for NPEPL1 Gene

Sources for NPEPL1 Gene

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