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Aliases for NPDC1 Gene

Aliases for NPDC1 Gene

  • Neural Proliferation, Differentiation And Control 1 2 3 5
  • NPDC-1 3 4
  • Neural Proliferation Differentiation And Control Protein 1 3
  • CAB-1 3
  • CAB1 3
  • CAB- 3
  • CAB 3

External Ids for NPDC1 Gene

Previous GeneCards Identifiers for NPDC1 Gene

  • GC09M131083
  • GC09M131623
  • GC09M133373
  • GC09M135291
  • GC09M137209
  • GC09M139053
  • GC09M139933
  • GC09M109393

Summaries for NPDC1 Gene

GeneCards Summary for NPDC1 Gene

NPDC1 (Neural Proliferation, Differentiation And Control 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NPDC1 Gene

  • Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Wiki entry for NPDC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPDC1 Gene

Genomics for NPDC1 Gene

Regulatory Elements for NPDC1 Gene

Enhancers for NPDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F137053 0.2 ENCODE 8 -9.0 -8973 2.6 MLX ARID4B DMAP1 ZNF48 YY1 GLIS2 FOS SP3 SP5 MIER2 MAN1B1 UAP1L1 DPP7 GRIN1 RABL6 CCDC183 NPDC1 ENSG00000229257 ENTPD2
GH09F137064 0.6 Ensembl ENCODE 7.9 -18.0 -17977 0.4 HDGF ELF3 KLF17 ARID4B ZNF48 ZNF2 RAD21 EGR1 ZNF143 CREM UAP1L1 NPDC1 ENSG00000231864 SAPCD2
GH09F137042 0.2 ENCODE 7.2 +1.2 1171 4.5 ARID4B SIN3A ZNF48 ZNF2 SLC30A9 GLIS2 ZNF143 KLF7 DEK ZNF263 UAP1L1 MAN1B1 NPDC1 FUT7 ENSG00000279073
GH09F137021 0.8 Ensembl ENCODE 5.7 +24.0 24049 1.3 TBP HDGF ATF1 KLF17 ARID4B THRB ZEB1 RFX5 SCRT2 RCOR1 LCNL1 NPDC1 C9orf139 PIR32105
GH09F137216 0.8 Ensembl ENCODE 4.6 -172.1 -172056 3.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 SLC30A9 FOS KLF13 SP3 SP5 FAM157B NDOR1 RNF208 CYSRT1 NPDC1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NPDC1 on UCSC Golden Path with GeneCards custom track

Promoters for NPDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001317875 424 2001 MLX ARID4B SIN3A ZNF48 ZNF2 SLC30A9 GLIS2 ZNF143 KLF7 DEK

Genomic Location for NPDC1 Gene

Chromosome:
9
Start:
137,039,457 bp from pter
End:
137,046,224 bp from pter
Size:
6,768 bases
Orientation:
Minus strand

Genomic View for NPDC1 Gene

Genes around NPDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPDC1 Gene

Proteins for NPDC1 Gene

  • Protein details for NPDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQX5-NPDC1_HUMAN
    Recommended name:
    Neural proliferation differentiation and control protein 1
    Protein Accession:
    Q9NQX5
    Secondary Accessions:
    • Q5SPY8
    • Q9BTD6
    • Q9BXT3
    • Q9NQS2
    • Q9Y434

    Protein attributes for NPDC1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPDC1 Gene

Post-translational modifications for NPDC1 Gene

  • Glycosylation at Thr 115, Thr 130, and Ser 134
  • Modification sites at PhosphoSitePlus

Other Protein References for NPDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPDC1 Gene

Domains & Families for NPDC1 Gene

Protein Domains for NPDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQX5

UniProtKB/Swiss-Prot:

NPDC1_HUMAN :
  • Belongs to the NPDC1/cab-1 family.
Family:
  • Belongs to the NPDC1/cab-1 family.
genes like me logo Genes that share domains with NPDC1: view

No data available for Gene Families for NPDC1 Gene

Function for NPDC1 Gene

Molecular function for NPDC1 Gene

UniProtKB/Swiss-Prot Function:
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Ontology (GO) - Molecular Function for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NPDC1: view

Phenotypes for NPDC1 Gene

MGI mutant phenotypes for NPDC1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPDC1: view

Animal Models for NPDC1 Gene

MGI Knock Outs for NPDC1:

Animal Model Products

miRNA for NPDC1 Gene

miRTarBase miRNAs that target NPDC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPDC1 Gene

Localization for NPDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPDC1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPDC1 Gene COMPARTMENTS Subcellular localization image for NPDC1 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPDC1: view

Pathways & Interactions for NPDC1 Gene

SuperPathways for NPDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPDC1 Gene

Transcripts for NPDC1 Gene

Unigene Clusters for NPDC1 Gene

Neural proliferation, differentiation and control, 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - -
SP8: -

Relevant External Links for NPDC1 Gene

GeneLoc Exon Structure for
NPDC1
ECgene alternative splicing isoforms for
NPDC1

Expression for NPDC1 Gene

mRNA expression in normal human tissues for NPDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NPDC1 Gene

This gene is overexpressed in Cerebrospinal fluid (45.9), Pancreas (8.2), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NPDC1 Gene



Protein tissue co-expression partners for NPDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NPDC1 Gene:

NPDC1

SOURCE GeneReport for Unigene cluster for NPDC1 Gene:

Hs.719906

mRNA Expression by UniProt/SwissProt for NPDC1 Gene:

Q9NQX5-NPDC1_HUMAN
Tissue specificity: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.
genes like me logo Genes that share expression patterns with NPDC1: view

Primer Products

No data available for mRNA differential expression in normal tissues for NPDC1 Gene

Orthologs for NPDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPDC1 34 35
  • 82.8 (n)
dog
(Canis familiaris)
Mammalia NPDC1 34 35
  • 80.1 (n)
rat
(Rattus norvegicus)
Mammalia Npdc1 34
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Npdc1 34 16 35
  • 79 (n)
chimpanzee
(Pan troglodytes)
Mammalia NPDC1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPDC1 34 35
  • 62.98 (n)
lizard
(Anolis carolinensis)
Reptilia NPDC1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497919 34
  • 65.84 (n)
Str.10620 34
zebrafish
(Danio rerio)
Actinopterygii npdc1a 34
  • 54.86 (n)
NPDC1 (1 of 2) 35
  • 40 (a)
OneToMany
npdc1 35
  • 39 (a)
OneToMany
sbcb1030 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2189 34
fruit fly
(Drosophila melanogaster)
Insecta Atf-2 35
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cab-1 35
  • 15 (a)
OneToOne
Species where no ortholog for NPDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPDC1 Gene

ENSEMBL:
Gene Tree for NPDC1 (if available)
TreeFam:
Gene Tree for NPDC1 (if available)

Paralogs for NPDC1 Gene

Pseudogenes.org Pseudogenes for NPDC1 Gene

genes like me logo Genes that share paralogs with NPDC1: view

No data available for Paralogs for NPDC1 Gene

Variants for NPDC1 Gene

Sequence variations from dbSNP and Humsavar for NPDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10747042 -- 137,044,154(+) GCTGG(C/T)TTGGT intron-variant
rs10781534 -- 137,039,137(+) CAGCC(C/T)TCTTT downstream-variant-500B
rs10781535 -- 137,043,343(+) CTGAG(C/T)CTCGC intron-variant
rs10781536 -- 137,043,347(+) GTCTC(A/G)CCGTC intron-variant
rs111321259 -- 137,043,607(+) TGTCC(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPDC1 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616004 CNV loss 21841781
nsv616005 CNV loss 21841781
nsv951206 CNV deletion 24416366

Variation tolerance for NPDC1 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPDC1 Gene

Disorders for NPDC1 Gene

Relevant External Links for NPDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPDC1

No disorders were found for NPDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPDC1 Gene

Publications for NPDC1 Gene

  1. Characterization and tissue expression of a novel human gene npdc1. (PMID: 11245976) Qu X. … He F. (Gene 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Functional analysis of the NPDC-1 gene. (PMID: 15563841) Evrard C. … Rouget P. (Gene 2004) 3 22 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for NPDC1 Gene

Sources for NPDC1 Gene

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