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Aliases for NPDC1 Gene

Aliases for NPDC1 Gene

  • Neural Proliferation, Differentiation And Control, 1 2 3
  • NPDC-1 3 4
  • CAB1 3 6
  • Neural Proliferation Differentiation And Control Protein 1 3
  • CAB-1 3
  • CAB- 3
  • CAB 3

External Ids for NPDC1 Gene

Previous GeneCards Identifiers for NPDC1 Gene

  • GC09M131083
  • GC09M131623
  • GC09M133373
  • GC09M135291
  • GC09M137209
  • GC09M139053
  • GC09M139933
  • GC09M109393

Summaries for NPDC1 Gene

GeneCards Summary for NPDC1 Gene

NPDC1 (Neural Proliferation, Differentiation And Control, 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NPDC1 Gene

  • Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Wiki entry for NPDC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPDC1 Gene

Genomics for NPDC1 Gene

Regulatory Elements for NPDC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPDC1 Gene

137,039,457 bp from pter
137,046,224 bp from pter
6,768 bases
Minus strand

Genomic View for NPDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPDC1 Gene

Proteins for NPDC1 Gene

  • Protein details for NPDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neural proliferation differentiation and control protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5SPY8
    • Q9BTD6
    • Q9BXT3
    • Q9NQS2
    • Q9Y434

    Protein attributes for NPDC1 Gene

    325 amino acids
    Molecular mass:
    34516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPDC1 Gene

Proteomics data for NPDC1 Gene at MOPED

Post-translational modifications for NPDC1 Gene

  • Glycosylation at Ser114, Thr115, Thr130, and Ser134
  • Modification sites at PhosphoSitePlus

Other Protein References for NPDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPDC1 Gene

Domains for NPDC1 Gene

Protein Domains for NPDC1 Gene


Suggested Antigen Peptide Sequences for NPDC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NQX5
  • Belongs to the NPDC1/cab-1 family.
genes like me logo Genes that share domains with NPDC1: view

No data available for Gene Families for NPDC1 Gene

Function for NPDC1 Gene

Molecular function for NPDC1 Gene

UniProtKB/Swiss-Prot Function: Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Ontology (GO) - Molecular Function for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NPDC1: view

Phenotypes for NPDC1 Gene

MGI mutant phenotypes for NPDC1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPDC1: view

Animal Models for NPDC1 Gene

MGI Knock Outs for NPDC1:

Animal Model Products

CRISPR Products

miRNA for NPDC1 Gene

miRTarBase miRNAs that target NPDC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPDC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NPDC1 Gene

Localization for NPDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPDC1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPDC1 Gene COMPARTMENTS Subcellular localization image for NPDC1 gene
Compartment Confidence
extracellular 2
plasma membrane 2
chloroplast 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPDC1: view

Pathways for NPDC1 Gene

SuperPathways for NPDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPDC1 Gene


No data available for Pathways by source for NPDC1 Gene

Transcripts for NPDC1 Gene

Unigene Clusters for NPDC1 Gene

Neural proliferation, differentiation and control, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPDC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP7: - -
SP8: -

Relevant External Links for NPDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPDC1 Gene

mRNA expression in normal human tissues for NPDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPDC1 Gene

SOURCE GeneReport for Unigene cluster for NPDC1 Gene Hs.719906

mRNA Expression by UniProt/SwissProt for NPDC1 Gene

Tissue specificity: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe
genes like me logo Genes that share expressions with NPDC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NPDC1 Gene

Orthologs for NPDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPDC1 36
  • 65 (a)
(Bos Taurus)
Mammalia NPDC1 35
  • 82.8 (n)
  • 81.85 (a)
NPDC1 36
  • 64 (a)
(Canis familiaris)
Mammalia NPDC1 35
  • 80.1 (n)
  • 78.71 (a)
NPDC1 36
  • 78 (a)
(Mus musculus)
Mammalia Npdc1 35
  • 79 (n)
  • 79.87 (a)
Npdc1 16
Npdc1 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Npdc1 35
  • 79.37 (n)
  • 79.48 (a)
(Gallus gallus)
Aves NPDC1 35
  • 62.98 (n)
  • 54.94 (a)
NPDC1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia NPDC1 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497919 35
  • 65.84 (n)
  • 59.5 (a)
Str.10620 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2189 35
(Danio rerio)
Actinopterygii npdc1 36
  • 39 (a)
NPDC1 (1 of 2) 36
  • 40 (a)
npdc1a 35
  • 54.86 (n)
  • 50 (a)
sbcb1030 35
fruit fly
(Drosophila melanogaster)
Insecta Atf-2 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea cab-1 36
  • 15 (a)
Species with no ortholog for NPDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPDC1 Gene

Gene Tree for NPDC1 (if available)
Gene Tree for NPDC1 (if available)

Paralogs for NPDC1 Gene Pseudogenes for NPDC1 Gene

genes like me logo Genes that share paralogs with NPDC1: view

No data available for Paralogs for NPDC1 Gene

Variants for NPDC1 Gene

Sequence variations from dbSNP and Humsavar for NPDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6604 -- 137,039,655(-) GGCCT(C/T)GGGCT utr-variant-3-prime
rs6605 -- 137,039,568(-) CTGTT(C/T)GGTTT utr-variant-3-prime
rs11438 -- 137,039,654(+) GAGCC(C/G)AAGGC utr-variant-3-prime
rs2891950 -- 137,045,741(+) GGGCC(C/G)CCGCC intron-variant
rs3814504 -- 137,047,496(-) AGCCC(C/G)AGCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPDC1 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8425n71 CNV Loss 21882294
nsv894514 CNV Loss 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8433n71 CNV Gain 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8438n71 CNV Loss 21882294
dgv8439n71 CNV Loss 21882294
dgv8440n71 CNV Loss 21882294
nsv894567 CNV Loss 21882294
nsv894570 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8443n71 CNV Loss 21882294
dgv8444n71 CNV Loss 21882294

Relevant External Links for NPDC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPDC1 Gene

Disorders for NPDC1 Gene

No disorders were found for NPDC1 Gene.

No data available for UniProtKB/Swiss-Prot for NPDC1 Gene

Publications for NPDC1 Gene

  1. Characterization and tissue expression of a novel human gene npdc1. (PMID: 11245976) Qu X. … He F. (Gene 2001) 2 3 4
  2. Functional analysis of the NPDC-1 gene. (PMID: 15563841) Evrard C. … Rouget P. (Gene 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. (PMID: 17577209) Miele A. … Stein J.L. (J. Cell. Biochem. 2007) 3

Products for NPDC1 Gene

Sources for NPDC1 Gene

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