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Aliases for NPDC1 Gene

Aliases for NPDC1 Gene

  • Neural Proliferation, Differentiation And Control, 1 2 3 5
  • NPDC-1 3 4
  • CAB-1 3
  • CAB1 3
  • CAB- 3
  • CAB 3

External Ids for NPDC1 Gene

Previous GeneCards Identifiers for NPDC1 Gene

  • GC09M131083
  • GC09M131623
  • GC09M133373
  • GC09M135291
  • GC09M137209
  • GC09M139053
  • GC09M139933
  • GC09M109393

Summaries for NPDC1 Gene

GeneCards Summary for NPDC1 Gene

NPDC1 (Neural Proliferation, Differentiation And Control, 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NPDC1 Gene

  • Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Wiki entry for NPDC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPDC1 Gene

Genomics for NPDC1 Gene

Regulatory Elements for NPDC1 Gene

Enhancers for NPDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPDC1 on UCSC Golden Path with GeneCards custom track

Promoters for NPDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NPDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPDC1 Gene

Chromosome:
9
Start:
137,039,457 bp from pter
End:
137,046,224 bp from pter
Size:
6,768 bases
Orientation:
Minus strand

Genomic View for NPDC1 Gene

Genes around NPDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPDC1 Gene

Proteins for NPDC1 Gene

  • Protein details for NPDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQX5-NPDC1_HUMAN
    Recommended name:
    Neural proliferation differentiation and control protein 1
    Protein Accession:
    Q9NQX5
    Secondary Accessions:
    • Q5SPY8
    • Q9BTD6
    • Q9BXT3
    • Q9NQS2
    • Q9Y434

    Protein attributes for NPDC1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPDC1 Gene

Proteomics data for NPDC1 Gene at MOPED

Post-translational modifications for NPDC1 Gene

  • Glycosylation at Thr 115, Thr 130, and Ser 134
  • Modification sites at PhosphoSitePlus

Other Protein References for NPDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPDC1 Gene

Domains & Families for NPDC1 Gene

Protein Domains for NPDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQX5

UniProtKB/Swiss-Prot:

NPDC1_HUMAN :
  • Belongs to the NPDC1/cab-1 family.
Family:
  • Belongs to the NPDC1/cab-1 family.
genes like me logo Genes that share domains with NPDC1: view

No data available for Gene Families for NPDC1 Gene

Function for NPDC1 Gene

Molecular function for NPDC1 Gene

UniProtKB/Swiss-Prot Function:
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Phenotypes for NPDC1 Gene

MGI mutant phenotypes for NPDC1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NPDC1: view

Animal Models for NPDC1 Gene

MGI Knock Outs for NPDC1:

Animal Model Products

miRNA for NPDC1 Gene

miRTarBase miRNAs that target NPDC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPDC1 Gene

Localization for NPDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPDC1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPDC1 Gene COMPARTMENTS Subcellular localization image for NPDC1 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for NPDC1 Gene

Pathways & Interactions for NPDC1 Gene

SuperPathways for NPDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NPDC1 Gene

Drugs & Compounds for NPDC1 Gene

No Compound Related Data Available

Transcripts for NPDC1 Gene

Unigene Clusters for NPDC1 Gene

Neural proliferation, differentiation and control, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - -
SP8: -

Relevant External Links for NPDC1 Gene

GeneLoc Exon Structure for
NPDC1
ECgene alternative splicing isoforms for
NPDC1

Expression for NPDC1 Gene

mRNA expression in normal human tissues for NPDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NPDC1 Gene

This gene is overexpressed in Cerebrospinal fluid (45.9), Pancreas (8.2), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NPDC1 Gene



SOURCE GeneReport for Unigene cluster for NPDC1 Gene Hs.719906

mRNA Expression by UniProt/SwissProt for NPDC1 Gene

Q9NQX5-NPDC1_HUMAN
Tissue specificity: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.
genes like me logo Genes that share expression patterns with NPDC1: view

Protein tissue co-expression partners for NPDC1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for NPDC1 Gene

Orthologs for NPDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPDC1 35
  • 82.8 (n)
  • 81.85 (a)
NPDC1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPDC1 35
  • 80.1 (n)
  • 78.71 (a)
NPDC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npdc1 35
  • 79 (n)
  • 79.87 (a)
Npdc1 16
Npdc1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npdc1 35
  • 79.37 (n)
  • 79.48 (a)
chimpanzee
(Pan troglodytes)
Mammalia NPDC1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPDC1 35
  • 62.98 (n)
  • 54.94 (a)
NPDC1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPDC1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497919 35
  • 65.84 (n)
  • 59.5 (a)
Str.10620 35
zebrafish
(Danio rerio)
Actinopterygii npdc1a 35
  • 54.86 (n)
  • 50 (a)
sbcb1030 35
npdc1 36
  • 39 (a)
OneToMany
NPDC1 (1 of 2) 36
  • 40 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2189 35
fruit fly
(Drosophila melanogaster)
Insecta Atf-2 36
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cab-1 36
  • 15 (a)
OneToOne
Species with no ortholog for NPDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPDC1 Gene

ENSEMBL:
Gene Tree for NPDC1 (if available)
TreeFam:
Gene Tree for NPDC1 (if available)

Paralogs for NPDC1 Gene

Pseudogenes.org Pseudogenes for NPDC1 Gene

genes like me logo Genes that share paralogs with NPDC1: view

No data available for Paralogs for NPDC1 Gene

Variants for NPDC1 Gene

Sequence variations from dbSNP and Humsavar for NPDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113067039 -- 137,046,812(+) GCATC(-/T)TTTTT upstream-variant-2KB
rs113118194 -- 137,041,555(+) GGAGT(A/C/G)GGGGG intron-variant
rs113220860 -- 137,039,971(+) CTCAC(C/T)GGGGC reference, synonymous-codon
rs113531841 -- 137,043,542(+) TCCCC(A/T)GAACC intron-variant
rs113750077 -- 137,042,890(+) GCAGG(A/G)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPDC1 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8425n71 CNV Loss 21882294
nsv894514 CNV Loss 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8433n71 CNV Gain 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8438n71 CNV Loss 21882294
dgv8439n71 CNV Loss 21882294
dgv8440n71 CNV Loss 21882294
nsv894567 CNV Loss 21882294
nsv894570 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8443n71 CNV Loss 21882294
dgv8444n71 CNV Loss 21882294

Variation tolerance for NPDC1 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NPDC1 Gene

Disorders for NPDC1 Gene

Relevant External Links for NPDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPDC1

No disorders were found for NPDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPDC1 Gene

Publications for NPDC1 Gene

  1. Characterization and tissue expression of a novel human gene npdc1. (PMID: 11245976) Qu X. … He F. (Gene 2001) 2 3 4 67
  2. Functional analysis of the NPDC-1 gene. (PMID: 15563841) Evrard C. … Rouget P. (Gene 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NPDC1 Gene

Sources for NPDC1 Gene

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