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NPBWR2 Gene

protein-coding   GIFtS: 54
GCID: GC20M062737

Neuropeptides B/W Receptor 2

(Previous name: G protein-coupled receptor 8)
(Previous symbol: GPR8)
  Search for NPBWR2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptides B/W Receptor 21 2
GPR81 2 3 5
G Protein-Coupled Receptor 81 2
G-Protein Coupled Receptor 82 3
Neuropeptides B/W Receptor Type 22
Opioid-Somatostatin-Like Receptor 82

External Ids:    HGNC: 45301   Entrez Gene: 28322   Ensembl: ENSG000001255227   OMIM: 6007315   UniProtKB: P481463   

Export aliases for NPBWR2 gene to outside databases

Previous GC identifers: GC20M062209 GC20M059465


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPBWR2 Gene:
The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded
protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to
opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is
expressed primarily in the frontal cortex of the brain. (provided by RefSeq, Jul 2008)

GeneCards Summary for NPBWR2 Gene:
NPBWR2 (neuropeptides B/W receptor 2) is a protein-coding gene. GO annotations related to this gene include opioid receptor activity and neuropeptide receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: NPBW2_HUMAN, P48146
Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be
involved in neuroendocrine system regulation, food intake and the organization of other signals

Gene Wiki entry for NPBWR2 (Neuropeptides B/W receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  NT_187624.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPBWR2 gene promoter:
         GATA-3   p53   SREBP-1c   E47   C/EBPalpha   GATA-2   RORalpha1   PPAR-gamma1   Hand1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPBWR2 promoter sequence
   Search Chromatin IP Primers for NPBWR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPBWR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

NPBWR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPBWR2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M062737:  view genomic region     (about GC identifiers)

Start:
62,737,173 bp from pter      End:
62,738,524 bp from pter
Size:
1,352 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPBW2_HUMAN, P48146 (See protein sequence)
Recommended Name: Neuropeptides B/W receptor type 2  
Size: 333 amino acids; 36861 Da
Secondary accessions: Q6NWQ6 Q9H4K3

Explore the universe of human proteins at neXtProt for NPBWR2: NX_P48146

Explore proteomics data for NPBWR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn24, Asn29, Asn34
  • Modification sites at PhosphoSitePlus

  • See NPBWR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005277.2  
    ENSEMBL proteins: 
     ENSP00000358783  
    Reactome Protein details: P48146

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPBWR: GPCR / Class A : Neuropeptide receptors : W/B

    IUPHAR Guide to PHARMACOLOGY protein family classification: NPBW2 receptor
    Neuropeptide W/neuropeptide B receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009150 Neuropept_B/W_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR027349 NPBW2

    Graphical View of Domain Structure for InterPro Entry P48146

    ProtoNet protein and cluster: P48146

    UniProtKB/Swiss-Prot: NPBW2_HUMAN, P48146
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NPBWR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPBW2_HUMAN, P48146
    Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be
    involved in neuroendocrine system regulation, food intake and the organization of other signals

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004985opioid receptor activity TAS7590751
    GO:0005515protein binding IPI12401809
    GO:0008188neuropeptide receptor activity IEA--
         
    Find genes that share ontologies with NPBWR2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPBWR2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPBW2_HUMAN, P48146: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC12401809

    Find genes that share ontologies with NPBWR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPBWR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with NPBWR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NPBWR2
        GPCRs, Class A Rhodopsin-like


    2 Reactome Pathways for NPBWR2
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for NPBWR2):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including NPBWR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NPBWR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPBWR2 (P481463 ENSP000003587834) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPBQ8NG413, ENSP000003327664I2D: score=1 STRING: ENSP00000332766
    NPWQ8N7293, ENSP000003300704I2D: score=1 STRING: ENSP00000330070
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    AGTR2ENSP000003609734STRING: ENSP00000360973
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA12401809
    GO:0038003opioid receptor signaling pathway TAS7590751

    Find genes that share ontologies with NPBWR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPBWR2 (NPBW2)

    5 IUPHAR Ligands for NPBWR2 (NPBW2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    neuropeptide W-23
    AgonistFull agonist9.612401809
    neuropeptide W-30
    AgonistFull agonist9.412401809
    neuropeptide B-29
    AgonistFull agonist912401809
    neuropeptide B-23
    AgonistFull agonist8.412401809
    [125I]NPW-23 (human)
    AgonistAgonist7.712130646



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPBWR2 gene: 
    NM_005286.2  

    Unigene Cluster for NPBWR2:

    Neuropeptides B/W receptor 2
    Hs.248118  [show with all ESTs]
    Unigene Representative Sequence: NM_005286
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369768(uc011abt.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NPBWR2
      QuantiFast Probe-based Assays in human, mouse, rat NPBWR2

    Additional mRNA sequence: 

    BC067481.1 BC067482.1 BC067483.1 

    1 DOTS entry:

    DT.92021785 

    7 AceView cDNA sequences:

    NM_005286 BC067481 BC067482 BC067483 CD559647 CD559646 CD559648 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPBWR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGCGCA
    NPBWR2 Expression
    About this image

    NPBWR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPBWR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248118

    UniProtKB/Swiss-Prot: NPBW2_HUMAN, P48146
    Tissue specificity: Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in
    the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes

        Pathway & Disease-focused RT2 Profiler PCR Array including NPBWR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPBWR2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia NPBWR26
    neuropeptides B/W receptor 2
    63(a)
    1 ↔ 1
    1(472322030-472323100)
    chicken
    (Gallus gallus)
    Aves LOC7715981 neuropeptides B/W receptor type 2-like 70.73(n)
    69.87(a)
      771598  XM_003642485.2  XP_003642533.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPBWR26
    neuropeptides B/W receptor 2
    69(a)
    1 ↔ 1
    4(154963527-154964441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004872261 neuropeptides B/W receptor type 2-like 69.89(n)
    68.39(a)
      100487226  XM_004920116.1  XP_004920173.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5711231 Gpr7 70.11(n)
    72.66(a)
      571123  NM_001030258.1  NP_001025429.1 


    ENSEMBL Gene Tree for NPBWR2 (if available)
    TreeFam Gene Tree for NPBWR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPBWR2 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  SSTR52  MCHR22  SSTR12  GALR32  SSTR22  OPRM12  MCHR12  
    Selected SIMAP similar genes for NPBWR2 using alignment to 2 protein entries:     NPBW2_HUMAN (see all proteins) (see all similar genes):
    NPBWR1    CCR3    OPRD1    OPRK1    SSTR1    SSTR4
    OPRM1    OPRL1    SSTR2    CCR-5    CMKLR1    SSTR3
    SSTR5    CCR1    CCR5    CCR7    CCR8    GPR24

    Find genes that share paralogs with NPBWR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPBWR2 (see all 154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357664
    A colorectal cancer sample4--see VAR_0357662 G R mis40--------
    rs348969301,2
    C--62736713(-) CTTCCT/CGGACA 1 -- ds50014Minor allele frequency- C:0.14WA NA EA 360
    rs60626311,2
    H--62736723(+) GCAGAG/AACATG 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs340080751,2
    C,F--62736738(-) TGGGCA/GTATAC 1 -- ds50013Minor allele frequency- G:0.11WA NA EA 358
    rs789601521,2
    C--62736882(+) GATGGG/TGGTGA 1 -- ds50010--------
    rs1820687991,2
    --62736887(+) GGGTGA/GTGGTG 1 -- ds50010--------
    rs1401595141,2
    C--62736890(+) TGATGA/GTGGGG 1 -- ds50010--------
    rs1854235241,2
    --62736894(+) GGTGGG/TGGTGG 1 -- ds50010--------
    rs1905781661,2
    --62736924(+) GATGGG/TGGTGG 1 -- ds50010--------
    rs1822238401,2
    --62737022(+) TGATGA/GTGGGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NPBWR2 (62737173 - 62738524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NPBWR2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509785CNV Insertion20534489
    dgv4658n71CNV Loss21882294
    dgv4662n71CNV Loss21882294
    nsv913190CNV Loss21882294
    dgv4663n71CNV Loss21882294
    nsv913270CNV Loss21882294
    dgv4654n71CNV Loss21882294
    nsv913304CNV Loss21882294
    nsv470564CNV Gain18288195
    nsv428381CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPBWR2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600731    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NPBWR2:
    Cryptorchidism

    Find genes that share disorders with NPBWR2           About GenesLikeMe


    Export disorders for NPBWR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPBWR2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NPBWR2)
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    1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3, 9 Brezillon S.... Parmentier M. (J. Biol. Chem. 2003)
    2. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PubMed id 12719537)1, 2, 9 Tanaka H.... Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PubMed id 7590751)1, 2, 9 O'Dowd B.F.... George S.R. (Genomics 1995)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PubMed id 12130646)1, 9 Shimomura Y.... Fujino M. (J. Biol. Chem. 2002)
    6. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    7. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PubMed id 15797961)1 Mazzocchi G....Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2832 HGNC: 4530 AceView: GPR8 Ensembl:ENSG00000125522 euGenes: HUgn2832
    ECgene: NPBWR2 Kegg: 2832 H-InvDB: NPBWR2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPBWR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPBWR2 gene:
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    GeneCards and IP:
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