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Aliases for NPBWR2 Gene

Aliases for NPBWR2 Gene

  • Neuropeptides B/W Receptor 2 2 3
  • GPR8 3 4 6
  • G Protein-Coupled Receptor 8 2 3
  • G-Protein Coupled Receptor 8 3 4
  • Opioid-Somatostatin-Like Receptor 8 3
  • Neuropeptides B/W Receptor Type 2 3

External Ids for NPBWR2 Gene

Previous Symbols for NPBWR2 Gene

  • GPR8

Summaries for NPBWR2 Gene

Entrez Gene Summary for NPBWR2 Gene

  • The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPBWR2 Gene

NPBWR2 (Neuropeptides B/W Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide receptor activity and opioid receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for NPBWR2 Gene

  • Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals

Gene Wiki entry for NPBWR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPBWR2 Gene

Genomics for NPBWR2 Gene

Genomic Location for NPBWR2 Gene

64,105,820 bp from pter
64,107,171 bp from pter
1,352 bases
Minus strand

Genomic View for NPBWR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPBWR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPBWR2 Gene

Regulatory Elements for NPBWR2 Gene

Proteins for NPBWR2 Gene

  • Protein details for NPBWR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptides B/W receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q6NWQ6
    • Q9H4K3

    Protein attributes for NPBWR2 Gene

    333 amino acids
    Molecular mass:
    36861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPBWR2 Gene

Proteomics data for NPBWR2 Gene at MOPED

Post-translational modifications for NPBWR2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn24, Asn29, and Asn34

Other Protein References for NPBWR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPBWR2 Gene

Domains for NPBWR2 Gene

Gene Families for NPBWR2 Gene

  • NPBWR :GPCR / Class A : Neuropeptide receptors : W/B

Protein Domains for NPBWR2 Gene


  • Belongs to the G-protein coupled receptor 1 family.:
    • P48146
genes like me logo Genes that share domains with NPBWR2: view

Function for NPBWR2 Gene

Molecular function for NPBWR2 Gene

UniProtKB/Swiss-Prot Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals

Gene Ontology (GO) - Molecular Function for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004985 opioid receptor activity TAS 7590751
GO:0005515 protein binding IPI 12401809
GO:0008188 neuropeptide receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with NPBWR2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPBWR2 Gene

Localization for NPBWR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPBWR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPBWR2 Gene COMPARTMENTS Subcellular localization image for NPBWR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 12401809
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with NPBWR2: view

Pathways for NPBWR2 Gene

genes like me logo Genes that share pathways with NPBWR2: view

Pathways by source for NPBWR2 Gene

Gene Ontology (GO) - Biological Process for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
GO:0038003 opioid receptor signaling pathway TAS 7590751
genes like me logo Genes that share ontologies with NPBWR2: view

Compounds for NPBWR2 Gene

(5) IUPHAR Ligand for NPBWR2 Gene

Ligand Type Action Affinity Pubmed IDs
neuropeptide W-30 Agonist Full agonist 10.6
neuropeptide W-23 Agonist Full agonist 10
neuropeptide B-29 Agonist Full agonist 9.5
[125I]NPW-23 (human) Agonist Agonist 9.4
neuropeptide B-23 Agonist Full agonist 8.4
genes like me logo Genes that share compounds with NPBWR2: view

Transcripts for NPBWR2 Gene

mRNA/cDNA for NPBWR2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPBWR2 Gene

Neuropeptides B/W receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPBWR2 Gene

No ASD Table

Relevant External Links for NPBWR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPBWR2 Gene

mRNA expression in normal human tissues for NPBWR2 Gene

mRNA differential expression in normal tissues according to GTEx for NPBWR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (18.7), Brain - Cortex (10.5), Pituitary (5.6), and Brain - Anterior cingulate cortex (BA24) (4.8).

SOURCE GeneReport for Unigene cluster for NPBWR2 Gene Hs.248118

mRNA Expression by UniProt/SwissProt for NPBWR2 Gene

Tissue specificity: Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes.
genes like me logo Genes that share expressions with NPBWR2: view

Orthologs for NPBWR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPBWR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPBWR2 36
  • 98.88 (n)
  • 99.39 (a)
(Bos Taurus)
Mammalia NPBWR2 36
  • 82.33 (n)
  • 77.41 (a)
  • 76 (a)
(Monodelphis domestica)
Mammalia NPBWR2 37
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia NPBWR2 37
  • 71 (a)
(Gallus gallus)
Aves LOC771598 36
  • 70.73 (n)
  • 69.87 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia NPBWR2 37
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487226 36
  • 69.89 (n)
  • 68.39 (a)
(Danio rerio)
Actinopterygii LOC571123 36
  • 70.11 (n)
  • 72.66 (a)
NPBWR2 (1 of 2) 37
  • 63 (a)
npbwr2a 37
  • 29 (a)
Species with no ortholog for NPBWR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPBWR2 Gene

Gene Tree for NPBWR2 (if available)
Gene Tree for NPBWR2 (if available)

Paralogs for NPBWR2 Gene

genes like me logo Genes that share paralogs with NPBWR2: view

Variants for NPBWR2 Gene

Sequence variations from dbSNP and Humsavar for NPBWR2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs910883 -- 64,108,214(-) TGTGA(C/T)GCTCA upstream-variant-2KB
rs3003153 -- 64,108,700(+) GGTTA(C/T)AGCCA upstream-variant-2KB
rs3076936 -- 64,107,923(+) gtgtg(-/TG)ccagt upstream-variant-2KB
rs4809400 -- 64,106,184(+) ACCAA(A/C)GTGTA reference, synonymous-codon
rs4809401 - 64,106,215(+) AGACC(C/T)GCTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NPBWR2 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4662n71 CNV Loss 21882294
dgv4663n71 CNV Loss 21882294

Relevant External Links for NPBWR2 Gene

HapMap Linkage Disequilibrium report

Disorders for NPBWR2 Gene

(1) University of Copenhagen DISEASES for NPBWR2 Gene

genes like me logo Genes that share disorders with NPBWR2: view

No data available for UniProtKB/Swiss-Prot for NPBWR2 Gene

Publications for NPBWR2 Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H. … Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  3. The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PMID: 7590751) O'Dowd B.F. … George S.R. (Genomics 1995) 3 4 23
  4. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. (PMID: 12130646) Shimomura Y. … Fujino M. (J. Biol. Chem. 2002) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for NPBWR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NPBWR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NPBWR2
    • Block miRNA regulation of NPBWR2 using miScript Target Protectors
    • antibodies-online peptides for NPBWR2
    • antibodies-online antibodies for NPBWR2
    • antibodies-online kits for NPBWR2

    Sources for NPBWR2 Gene

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