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Aliases for NPBWR2 Gene

Aliases for NPBWR2 Gene

  • Neuropeptides B/W Receptor 2 2 3
  • G Protein-Coupled Receptor 8 2 3
  • G-Protein Coupled Receptor 8 3 4
  • GPR8 3 4
  • Opioid-Somatostatin-Like Receptor 8 3

External Ids for NPBWR2 Gene

Previous HGNC Symbols for NPBWR2 Gene

  • GPR8

Previous GeneCards Identifiers for NPBWR2 Gene

  • GC20M062209
  • GC20M062737
  • GC20M059465

Summaries for NPBWR2 Gene

Entrez Gene Summary for NPBWR2 Gene

  • The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPBWR2 Gene

NPBWR2 (Neuropeptides B/W Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for NPBWR2 Gene

  • Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals

Gene Wiki entry for NPBWR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPBWR2 Gene

Genomics for NPBWR2 Gene

Regulatory Elements for NPBWR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NPBWR2 Gene

Chromosome:
20
Start:
64,105,820 bp from pter
End:
64,107,171 bp from pter
Size:
1,352 bases
Orientation:
Minus strand

Genomic View for NPBWR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NPBWR2 Gene

Proteins for NPBWR2 Gene

  • Protein details for NPBWR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48146-NPBW2_HUMAN
    Recommended name:
    Neuropeptides B/W receptor type 2
    Protein Accession:
    P48146
    Secondary Accessions:
    • Q6NWQ6
    • Q9H4K3

    Protein attributes for NPBWR2 Gene

    Size:
    333 amino acids
    Molecular mass:
    36861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPBWR2 Gene

Proteomics data for NPBWR2 Gene at MOPED

Post-translational modifications for NPBWR2 Gene

  • Glycosylation at Asn 24, Asn 29, and Asn 34
  • Modification sites at PhosphoSitePlus

Other Protein References for NPBWR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPBWR2 Gene

Domains & Families for NPBWR2 Gene

Gene Families for NPBWR2 Gene

Protein Domains for NPBWR2 Gene

Suggested Antigen Peptide Sequences for NPBWR2 Gene

Graphical View of Domain Structure for InterPro Entry

P48146

UniProtKB/Swiss-Prot:

NPBW2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPBWR2: view

Function for NPBWR2 Gene

Molecular function for NPBWR2 Gene

UniProtKB/Swiss-Prot Function:
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals

Gene Ontology (GO) - Molecular Function for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004985 opioid receptor activity TAS 7590751
GO:0005515 protein binding IPI 12401809
GO:0008188 neuropeptide receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with NPBWR2: view

Phenotypes for NPBWR2 Gene

GenomeRNAi human phenotypes for NPBWR2:
genes like me logo Genes that share phenotypes with NPBWR2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPBWR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPBWR2 Gene

Localization for NPBWR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPBWR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPBWR2 Gene COMPARTMENTS Subcellular localization image for NPBWR2 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 12401809
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with NPBWR2: view

Pathways & Interactions for NPBWR2 Gene

genes like me logo Genes that share pathways with NPBWR2: view

Pathways by source for NPBWR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for NPBWR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
GO:0038003 opioid receptor signaling pathway TAS 7590751
genes like me logo Genes that share ontologies with NPBWR2: view

No data available for SIGNOR curated interactions for NPBWR2 Gene

Drugs & Compounds for NPBWR2 Gene

(5) Drugs for NPBWR2 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]NPW-23 (human) Pharma Agonist 0
neuropeptide B-23 Pharma Full agonist, Agonist 0
neuropeptide B-29 Pharma Full agonist, Agonist 0
neuropeptide W-23 Pharma Full agonist, Agonist 0
neuropeptide W-30 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with NPBWR2: view

Transcripts for NPBWR2 Gene

mRNA/cDNA for NPBWR2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPBWR2 Gene

Neuropeptides B/W receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NPBWR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPBWR2 Gene

No ASD Table

Relevant External Links for NPBWR2 Gene

GeneLoc Exon Structure for
NPBWR2
ECgene alternative splicing isoforms for
NPBWR2

Expression for NPBWR2 Gene

mRNA expression in normal human tissues for NPBWR2 Gene

mRNA differential expression in normal tissues according to GTEx for NPBWR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x18.7), Brain - Cortex (x10.5), Pituitary (x5.6), and Brain - Anterior cingulate cortex (BA24) (x4.8).

SOURCE GeneReport for Unigene cluster for NPBWR2 Gene Hs.248118

mRNA Expression by UniProt/SwissProt for NPBWR2 Gene

P48146-NPBW2_HUMAN
Tissue specificity: Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes.
genes like me logo Genes that share expression patterns with NPBWR2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NPBWR2 Gene

Orthologs for NPBWR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPBWR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPBWR2 35
  • 82.33 (n)
  • 77.41 (a)
NPBWR2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NPBWR2 35
  • 98.88 (n)
  • 99.39 (a)
oppossum
(Monodelphis domestica)
Mammalia NPBWR2 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NPBWR2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC771598 35
  • 70.73 (n)
  • 69.87 (a)
NPBWR2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPBWR2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487226 35
  • 69.89 (n)
  • 68.39 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC571123 35
  • 70.11 (n)
  • 72.66 (a)
NPBWR2 (1 of 2) 36
  • 63 (a)
OneToMany
npbwr2a 36
  • 29 (a)
OneToMany
Species with no ortholog for NPBWR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPBWR2 Gene

ENSEMBL:
Gene Tree for NPBWR2 (if available)
TreeFam:
Gene Tree for NPBWR2 (if available)

Paralogs for NPBWR2 Gene

genes like me logo Genes that share paralogs with NPBWR2: view

Variants for NPBWR2 Gene

Sequence variations from dbSNP and Humsavar for NPBWR2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_035766 A colorectal cancer sample
VAR_003579 -

Structural Variations from Database of Genomic Variants (DGV) for NPBWR2 Gene

Variant ID Type Subtype PubMed ID
nsv913190 CNV Loss 21882294
nsv428381 CNV Gain+Loss 18775914
nsv913270 CNV Loss 21882294
dgv4654n71 CNV Loss 21882294
nsv509785 CNV Insertion 20534489
dgv1346e1 CNV Complex 17122850
dgv1347e1 CNV Complex 17122850
dgv4658n71 CNV Loss 21882294
nsv913304 CNV Loss 21882294
nsv470564 CNV Gain 18288195
dgv4662n71 CNV Loss 21882294
dgv4663n71 CNV Loss 21882294

Variation tolerance for NPBWR2 Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPBWR2 Gene

HapMap Linkage Disequilibrium report
NPBWR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPBWR2 Gene

Disorders for NPBWR2 Gene

Relevant External Links for NPBWR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPBWR2
genes like me logo Genes that share disorders with NPBWR2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPBWR2 Gene

Publications for NPBWR2 Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 23 67
  2. Ontogeny of a new enteric peptide, neuropeptide W (NPW), in the developing rat stomach. (PMID: 17959264) Mondal M.S. … Nakazato M. (Regul. Pept. 2008) 23 67
  3. Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus. (PMID: 17067739) Schulz S. … HAPllt V. (Neurosci. Lett. 2007) 23 67
  4. Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PMID: 17486669) Kanesaka M. … Tokita S. (J. Pept. Sci. 2007) 23 67
  5. Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. (PMID: 16394174) Mondal M.S. … Nakazato M. (J. Endocrinol. 2006) 23 67

Products for NPBWR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NPBWR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NPBWR2
    • Block miRNA regulation of NPBWR2 using miScript Target Protectors

    Sources for NPBWR2 Gene

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