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NPBWR1 Gene

protein-coding   GIFtS: 56
GCID: GC08P053850

Neuropeptides B/W Receptor 1

(Previous name: G protein-coupled receptor 7)
(Previous symbol: GPR7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropeptides B/W Receptor 11 2     Neuropeptide B/W Receptor 12
GPR71 2 3 5     Neuropeptides B/W Receptor Type 12
G Protein-Coupled Receptor 71 2     Opioid-Somatostatin-Like Receptor 72
G-Protein Coupled Receptor 72 3     

External Ids:    HGNC: 45221   Entrez Gene: 28312   Ensembl: ENSG000001837297   OMIM: 6007305   UniProtKB: P481453   

Export aliases for NPBWR1 gene to outside databases

Previous GC identifers: GC08P054014 GC08P049319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NPBWR1 Gene:
NPBWR1 (neuropeptides B/W receptor 1) is a protein-coding gene. GO annotations related to this gene include opioid receptor activity and neuropeptide receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145
Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be
involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher
affinity for neuropeptide B

Gene Wiki entry for NPBWR1 (Neuropeptides B/W receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPBWR1 gene promoter:
         Oct-B1   oct-B3   oct-B2   SREBP-1c   E47   SREBP-1b   POU2F1   SREBP-1a   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPBWR1 promoter sequence
   Search Chromatin IP Primers for NPBWR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPBWR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-q21.13   Ensembl cytogenetic band:  8q11.23   HGNC cytogenetic band: 8p22-q21.13

NPBWR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPBWR1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P053850:  view genomic region     (about GC identifiers)

Start:
53,850,991 bp from pter      End:
53,853,677 bp from pter
Size:
2,687 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145 (See protein sequence)
Recommended Name: Neuropeptides B/W receptor type 1  
Size: 328 amino acids; 36103 Da
Secondary accessions: Q6NTC7

Explore the universe of human proteins at neXtProt for NPBWR1: NX_P48145

Explore proteomics data for NPBWR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn13, Asn25

  • See NPBWR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005276.2  
    ENSEMBL proteins: 
     ENSP00000330284  
    Reactome Protein details: P48145

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NPBWR: GPCR / Class A : Neuropeptide receptors : W/B

    IUPHAR Guide to PHARMACOLOGY protein family classification: NPBW1 receptor
    Neuropeptide W/neuropeptide B receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009150 Neuropept_B/W_rcpt
     IPR027348 NPBW1
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P48145

    ProtoNet protein and cluster: P48145

    1 Blocks protein domain: IPB000611 Neuropeptide Y receptor signature

    UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NPBWR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPBW1_HUMAN, P48145
    Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be
    involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher
    affinity for neuropeptide B

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004985opioid receptor activity TAS7590751
    GO:0005515protein binding IPI12401809
    GO:0008188neuropeptide receptor activity IEA--
         
    Find genes that share ontologies with NPBWR1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NPBWR1:
     Decreased G3BP1 protein expres  Increased Salmonella enterica   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Npbwr1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  liver/biliary system 

    Find genes that share phenotypes with NPBWR1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NPBWR1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPBW1_HUMAN, P48145: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IC12401809

    Find genes that share ontologies with NPBWR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NPBWR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46


    Find genes that share SuperPaths with NPBWR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NPBWR1
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for NPBWR1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for NPBWR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including NPBWR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NPBWR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NPBWR1 (P481453 ENSP000003302844) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPBQ8NG413, ENSP000003327664I2D: score=2 STRING: ENSP00000332766
    NPWQ8N7293, ENSP000003300704I2D: score=2 STRING: ENSP00000330070
    ADCY2ENSP000003429524STRING: ENSP00000342952
    AGTR2ENSP000003609734STRING: ENSP00000360973
    CASRENSP000002961544STRING: ENSP00000296154
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA12401809
    GO:0007268synaptic transmission TAS7590751
    GO:0019222regulation of metabolic process IEA--
    GO:0038003opioid receptor signaling pathway TAS7590751

    Find genes that share ontologies with NPBWR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NPBWR1 (NPBW1)

    9 IUPHAR Ligands for NPBWR1 (NPBW1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    neuropeptide W-30
    AgonistFull agonist10.612130646
    [125I][Tyr11]des-Br-NPB-23
    AgonistFull agonist10.412118011
    neuropeptide W-23
    AgonistFull agonist1012130646
    des-Br-neuropeptide B-29
    AgonistFull agonist9.512401809 12118011
    neuropeptide B-29
    AgonistFull agonist9.512118011
    Ava3
    AgonistFull agonist9.37 - 9.4317486669
    [125I]NPW-23 (human)
    AgonistAgonist9.415261118
    Ava5
    AgonistFull agonist8.8 - 917486669
    des-Br-neuropeptide B-23
    AgonistFull agonist8.812401809 12118011



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPBWR1 gene: 
    NM_005285.3  

    Unigene Cluster for NPBWR1:

    Neuropeptides B/W receptor 1
    Hs.248117  [show with all ESTs]
    Unigene Representative Sequence: NM_005285
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331251(uc011ldu.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NPBWR1
      QuantiFast Probe-based Assays in human, mouse, rat NPBWR1

    Additional mRNA sequence: 

    BC069117.1 BC107101.2 

    1 DOTS entry:

    DT.91874599 

    2 AceView cDNA sequences:

    BC069117 NM_005285 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPBWR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGGACA
    NPBWR1 Expression
    About this image

    NPBWR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPBWR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248117

    UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145
    Tissue specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and
    trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or
    liver. Also detected at high levels in lung carcinoma

        Pathway & Disease-focused RT2 Profiler PCR Array including NPBWR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NPBWR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npbwr11 , 5 neuropeptides B/W receptor 11, 5 82.98(n)1
    85.63(a)1
      1 (1.89 cM)5
    2263041  NM_010342.11  NP_034472.11 
     59137075 
    chicken
    (Gallus gallus)
    Aves NPBWR11 neuropeptides B/W receptor 1 65.65(n)
    65.85(a)
      421117  XM_004939856.1  XP_004939913.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPBWR16
    neuropeptides B/W receptor 1
    64(a)
    1 ↔ 1
    GL343244.1(1448454-1450444)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npbwr11 neuropeptides B/W receptor 1 67.14(n)
    71.17(a)
      100487994  XM_002934105.2  XP_002934151.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5564511 Gpr8 63.85(n)
    65(a)
      556451  NM_001130769.1  NP_001124241.1 


    ENSEMBL Gene Tree for NPBWR1 (if available)
    TreeFam Gene Tree for NPBWR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPBWR1 gene
    SSTR32  OPRL12  OPRK12  OPRD12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for NPBWR1 using alignment to 1 protein entry:     NPBW1_HUMAN(see all similar genes):
    NPBWR2    OPRD1    SSTR1    OPRL1    SSTR3    SSTR2
    OPRM1    OPRK1    SSTR4    SSTR5    BLR1    CCR1
    CCR7    CCR8    CXCR5    GPR24    MCHR2    APLNR

    Find genes that share paralogs with NPBWR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPBWR1 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357654
    A breast cancer sample4--see VAR_0357652 P Q mis40--------
    rs1177523101,2
    C,F--53850623(+) TGTGAA/GGAAGA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs616479321,2
    C,F--53850774(+) GGGGGG/ACTACT 1 -- us2k14Minor allele frequency- A:0.16WA NA 242
    rs787312181,2
    F--53850808(+) TACTGC/TCGACT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs736812551,2
    C,F--53850839(+) GGCCCC/TCTTCT 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1487217331,2
    --53850871(+) CAAAAA/CTACAC 1 -- us2k10--------
    rs3700922011,2
    C--53850973(+) AAAAA-/AGCAGA 1 -- us2k10--------
    rs119933171,2
    C,F,H--53851048(+) GAGGAG/CCCTAA 1 -- us2k12Minor allele frequency- C:0.05NA WA 120
    rs790127071,2
    F--53851114(+) GAGTTC/GAAGAC 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs755368361,2
    C,F--53851204(+) TGTGGA/GTAAGT 1 -- us2k11Minor allele frequency- G:0.08WA 118

    HapMap Linkage Disequilibrium report for NPBWR1 (53850991 - 53853677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NPBWR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890911CNV Loss21882294
    nsv890912CNV Loss21882294
    dgv7796n71CNV Loss21882294
    nsv8344CNV Loss18304495
    nsv824633CNV Gain20364138
    nsv890902CNV Gain21882294
    nsv890908CNV Gain21882294
    nsv525238CNV Gain19592680
    essv1561CNV CNV17122850
    essv1731CNV CNV17122850

    Human Gene Mutation Database (HGMD): NPBWR1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600730    OMIM disorders: --


    Find genes that share disorders with NPBWR1           About GenesLikeMe

    1 Novoseek inferred disease relationship for NPBWR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 17363522 (1)

    Genetic Association Database (GAD): NPBWR1

    Export disorders for NPBWR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NPBWR1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with NPBWR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PubMed id 7590751)1, 2, 3, 9 O'Dowd B.F.... George S.R. (Genomics 1995)
    2. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3 Brezillon S.... Parmentier M. (J. Biol. Chem. 2003)
    3. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PubMed id 12719537)1, 2 Tanaka H.... Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    4. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PubMed id 15797961)1, 9 Mazzocchi G....Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005)
    5. A prognostic DNA methylation signature for stage I non-small-cell lung cancer. (PubMed id 24081945)1 Sandoval J....Esteller M. (J. Clin. Oncol. 2013)
    6. A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions. (PubMed id 22545105)1 Watanabe N....Yamamoto M. (PLoS ONE 2012)
    7. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    8. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PubMed id 18057069)4 Cronin S....Hardiman O. (Hum. Mol. Genet. 2008)
    9. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    10. Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. (PubMed id 17437806)1 Cottrell S....Weiss G. (J. Urol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2831 HGNC: 4522 AceView: GPR7 Ensembl:ENSG00000183729 euGenes: HUgn2831
    ECgene: NPBWR1 Kegg: 2831 H-InvDB: NPBWR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NPBWR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NPBWR1 gene:
    Search GeneIP for patents involving NPBWR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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