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Aliases for NPBWR1 Gene

Aliases for NPBWR1 Gene

  • Neuropeptides B/W Receptor 1 2 3
  • GPR7 3 4 6
  • G Protein-Coupled Receptor 7 2 3
  • G-Protein Coupled Receptor 7 3 4
  • Opioid-Somatostatin-Like Receptor 7 3
  • Neuropeptides B/W Receptor Type 1 3
  • Neuropeptide B/W Receptor 1 3

External Ids for NPBWR1 Gene

Previous Symbols for NPBWR1 Gene

  • GPR7

Summaries for NPBWR1 Gene

GeneCards Summary for NPBWR1 Gene

NPBWR1 (Neuropeptides B/W Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide receptor activity and opioid receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for NPBWR1 Gene

  • Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B

Gene Wiki entry for NPBWR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPBWR1 Gene

Genomics for NPBWR1 Gene

Genomic Location for NPBWR1 Gene

52,938,431 bp from pter
52,941,117 bp from pter
2,687 bases
Plus strand

Genomic View for NPBWR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPBWR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPBWR1 Gene

Regulatory Elements for NPBWR1 Gene

Proteins for NPBWR1 Gene

  • Protein details for NPBWR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptides B/W receptor type 1
    Protein Accession:
    Secondary Accessions:
    • Q6NTC7

    Protein attributes for NPBWR1 Gene

    328 amino acids
    Molecular mass:
    36103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPBWR1 Gene

Proteomics data for NPBWR1 Gene at MOPED

Post-translational modifications for NPBWR1 Gene

  • Glycosylation at Asn3, Asn13, and Asn25

Other Protein References for NPBWR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPBWR1 Gene

Domains for NPBWR1 Gene

Gene Families for NPBWR1 Gene

  • NPBWR :GPCR / Class A : Neuropeptide receptors : W/B

Protein Domains for NPBWR1 Gene


  • Belongs to the G-protein coupled receptor 1 family.:
    • P48145
genes like me logo Genes that share domains with NPBWR1: view

Function for NPBWR1 Gene

Molecular function for NPBWR1 Gene

UniProtKB/Swiss-Prot Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B

Gene Ontology (GO) - Molecular Function for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004985 opioid receptor activity TAS 7590751
GO:0005515 protein binding IPI 12401809
GO:0008188 neuropeptide receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with NPBWR1: view
genes like me logo Genes that share phenotypes with NPBWR1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NPBWR1 Gene

Localization for NPBWR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPBWR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NPBWR1 Gene COMPARTMENTS Subcellular localization image for NPBWR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 12401809
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with NPBWR1: view

Pathways for NPBWR1 Gene

genes like me logo Genes that share pathways with NPBWR1: view

Pathways by source for NPBWR1 Gene

Gene Ontology (GO) - Biological Process for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission TAS 7590751
GO:0019222 regulation of metabolic process IEA --
genes like me logo Genes that share ontologies with NPBWR1: view

Compounds for NPBWR1 Gene

(9) IUPHAR Ligand for NPBWR1 Gene

Ligand Type Action Affinity Pubmed IDs
neuropeptide W-30 Agonist Full agonist 10.6
[125I][Tyr11]des-Br-NPB-23 Agonist Full agonist 10.4
neuropeptide W-23 Agonist Full agonist 10
des-Br-neuropeptide B-29 Agonist Full agonist 9.5
neuropeptide B-29 Agonist Full agonist 9.5
Ava3 Agonist Full agonist 9.43
[125I]NPW-23 (human) Agonist Agonist 9.4
Ava5 Agonist Full agonist 9
des-Br-neuropeptide B-23 Agonist Full agonist 8.8
genes like me logo Genes that share compounds with NPBWR1: view

Transcripts for NPBWR1 Gene

mRNA/cDNA for NPBWR1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPBWR1 Gene

Neuropeptides B/W receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPBWR1 Gene

No ASD Table

Relevant External Links for NPBWR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPBWR1 Gene

mRNA expression in normal human tissues for NPBWR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPBWR1 Gene

This gene is overexpressed in Liver (7.9), Skin - Not Sun Exposed (Suprapubic) (5.4), Brain - Hypothalamus (4.6), Brain - Anterior cingulate cortex (BA24) (4.4), and Pituitary (4.2).

SOURCE GeneReport for Unigene cluster for NPBWR1 Gene Hs.248117

mRNA Expression by UniProt/SwissProt for NPBWR1 Gene

Tissue specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
genes like me logo Genes that share expressions with NPBWR1: view

Orthologs for NPBWR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPBWR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPBWR1 36
  • 99.49 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia NPBWR1 36
  • 88.41 (n)
  • 87.69 (a)
  • 86 (a)
(Canis familiaris)
Mammalia NPBWR1 36
  • 88.52 (n)
  • 86.28 (a)
  • 89 (a)
(Mus musculus)
Mammalia Npbwr1 36
  • 82.98 (n)
  • 85.63 (a)
Npbwr1 16
Npbwr1 37
  • 84 (a)
(Monodelphis domestica)
Mammalia NPBWR1 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Npbwr1 36
  • 83.69 (n)
  • 86.54 (a)
(Gallus gallus)
Aves NPBWR1 36
  • 65.65 (n)
  • 65.85 (a)
  • 65 (a)
(Anolis carolinensis)
Reptilia NPBWR1 37
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia npbwr1 36
  • 67.14 (n)
  • 71.17 (a)
(Danio rerio)
Actinopterygii CABZ01043829.1 37
  • 35 (a)
LOC556451 36
  • 63.85 (n)
  • 65 (a)
Species with no ortholog for NPBWR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPBWR1 Gene

Gene Tree for NPBWR1 (if available)
Gene Tree for NPBWR1 (if available)

Paralogs for NPBWR1 Gene

genes like me logo Genes that share paralogs with NPBWR1: view

Variants for NPBWR1 Gene

Sequence variations from dbSNP and Humsavar for NPBWR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs545125 -- 52,938,902(+) TAGCC(C/T)ATTTG upstream-variant-2KB
rs545240 -- 52,938,946(+) CCACT(A/G)CATTG upstream-variant-2KB
rs648531 -- 52,939,110(+) TGTTC(C/T)AAGAC upstream-variant-2KB
rs6997767 -- 52,938,990(+) CTTTG(C/T)TTTCC upstream-variant-2KB
rs11993317 -- 52,938,488(+) GAGGA(C/G)CCTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPBWR1 Gene

Variant ID Type Subtype PubMed ID
nsv890902 CNV Gain 21882294
nsv890908 CNV Gain 21882294
essv1731 CNV CNV 17122850
essv1561 CNV CNV 17122850
nsv824633 CNV Gain 20364138
nsv890911 CNV Loss 21882294
nsv890912 CNV Loss 21882294
dgv7796n71 CNV Loss 21882294
nsv525238 CNV Gain 19592680
nsv8344 CNV Loss 18304495

Relevant External Links for NPBWR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NPBWR1 Gene

(1) Novoseek inferred disease relationships for NPBWR1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for NPBWR1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with NPBWR1: view

No data available for UniProtKB/Swiss-Prot for NPBWR1 Gene

Publications for NPBWR1 Gene

  1. The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PMID: 7590751) O'Dowd B.F. … George S.R. (Genomics 1995) 2 3 4 23
  2. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4
  3. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PMID: 15797961) Mazzocchi G. … Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005) 3 23
  4. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H. … Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  5. Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. (PMID: 15607941) Zaratin P.F. … Scheideler M.A. (Mol. Cell. Neurosci. 2005) 3

Products for NPBWR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NPBWR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NPBWR1
    • Block miRNA regulation of NPBWR1 using miScript Target Protectors
    • antibodies-online peptides for NPBWR1
    • antibodies-online antibodies for NPBWR1
    • antibodies-online kits for NPBWR1

    Sources for NPBWR1 Gene

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