NPBWR1 Gene
protein-coding GIFtS: 55
GCID: GC08P053850
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|
neuropeptides B/W receptor 1(Previous name: G protein-coupled receptor 7 )
(Previous symbol: GPR7)
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Aliases
for NPBWR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuropeptides B/W Receptor 11 2 | | Neuropeptide B/W Receptor 12 | | GPR71 2 3 5 | | Neuropeptides B/W Receptor Type 12 | | G Protein-Coupled Receptor 71 2 | | Opioid-Somatostatin-Like Receptor 72 | | G-Protein Coupled Receptor 72 3 | | |
Export aliases for NPBWR1 gene to outside databasesPrevious GC identifers: GC08P054014 GC08P049319 |
Summaries
for NPBWR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may beinvolved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinityfor neuropeptide B
Gene Wiki entry for NPBWR1 (Neuropeptides B/W receptor 1)
|
Genomic Views
for NPBWR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPBWR1 gene promoter:
Oct-B1 oct-B3 oct-B2 SREBP-1c E47 SREBP-1b POU2F1 SREBP-1a Cart-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPBWR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPBWR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p22-q21.13 Ensembl cytogenetic band: 8q11.23 HGNC cytogenetic band: 8p22-q21.13NPBWR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P053850: view genomic region
(about GC identifiers)
Start:
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53,850,991 bp from pter |
End:
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53,853,677 bp from pter |
Size:
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2,687 bases |
Orientation:
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plus strand |
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Proteins
for NPBWR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145 (See
protein sequence)Recommended Name: Neuropeptides B/W receptor type 1 Size: 328 amino acids; 36103 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6NTC7Explore the universe of human proteins at neXtProt for NPBWR1: NX_P48145
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48145
NPBWR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005276.2
ENSEMBL proteins: ENSP00000330284 Reactome Protein details: P48145
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NPBWR1 for ontologies About GeneDecksing
NPBWR1 Antibody Products:
Assay Products for NPBWR1: |
Protein
Domains /
Families
for NPBWR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPBWR1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48145ProtoNet protein and cluster: P48145 1 Blocks protein family: IPB000611 Neuropeptide Y receptor signature
UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for NPBWR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145Function: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may beinvolved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinityfor neuropeptide B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPBWR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPBWR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NPBWR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPBWR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPBWR1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NPBWR1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for NPBWR1:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Npbwr1):
NPBWR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NPBWR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NPBWR1
1  BioSystems Pathway for NPBWR1
5/7 
Reactome Pathways for NPBWR1 (see all 7)
1 
Kegg Pathway (Kegg details for NPBWR1):
NPBWR1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPBWR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/143 Interacting proteins for NPBWR1 (P481453 ENSP000003302844) via UniProtKB, MINT, STRING, and/or I2D (see all 143)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
NPBWR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NPBWR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPBWR1
Search CenterWatch for drugs/clinical trials and news about NPBWR1 / NPBW1
|
Transcripts
for NPBWR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPBWR1 gene: NM_005285.3 Unigene Cluster for NPBWR1: Neuropeptides B/W receptor 1 Hs.248117 [show with all ESTs]Unigene Representative Sequence: NM_0052851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000331251(uc011ldu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPBWR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPBWR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPBWR1 (NM_005285) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPBWR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPBWR1 |
Additional cDNA sequence: BC069117.1 BC107101.2 1 DOTS entry: DT.91874599 2 AceView cDNA sequences: NM_005285 BC069117
GeneLoc Exon Structure
|
Expression
for NPBWR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPBWR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGCTGGACA
About this image
See NPBWR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPBWR1
SOURCE GeneReport for Unigene cluster: Hs.248117
UniProtKB/Swiss-Prot: NPBW1_HUMAN, P48145Tissue specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala andtrachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver.Also detected at high levels in lung carcinoma
SABiosciences Expression via Pathway-Focused PCR Array including NPBWR1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPBWR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPBWR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPBWR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPBWR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPBWR1 |
Orthologs
for NPBWR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NPBWR1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for NPBWR1 (if available)
TreeFam Gene Tree for NPBWR1 (if available) |
Paralogs
for NPBWR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NPBWR1 gene
- SSTR32 OPRL12 OPRK12 OPRD12 KISS1R2 GALR12 SSTR42 SSTR52
- GALR22 MCHR22 SSTR12 GALR32 SSTR22 NPBWR22 MCHR12 OPRM12
18/38 SIMAP similar genes for NPBWR1 using alignment to 1 protein entry: NPBW1_HUMAN(see all similar genes):NPBWR2 OPRD1 SSTR1 OPRL1 SSTR3 OPRK1
OPRM1 SSTR2 SSTR4 SSTR5 BLR1 CCR1
CCR7 CCR8 CXCR5 GPR24 MCHR2 APLNR
NPBWR1 for paralogs About GeneDecksing
|
Genomic Variants
for NPBWR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPBWR1 (53850991 - 53853677 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NPBWR1
3 CNVs: 2754 3733 33037
Human Gene Mutation Database (HGMD): NPBWR1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPBWR1 |
|
Disorders
/ Diseases
for NPBWR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPBWR1 for disorders About GeneDecksing
OMIM gene information: 600730
OMIM disorders: --
11  diseases for NPBWR1: About MalaCardsprostate cancer, progression of prostate cancer hermaphroditism lung carcinoma
neuropathy pancreatic cancer prostatitis pancreatitis
immunodeficiency carcinoma neuronitis
1 Novoseek disease relationship for NPBWR1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
2 |
17363522 (1) |
Export disorders for NPBWR1 gene to outside databases
|
Publications
for NPBWR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPBWR1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NPBWR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PubMed id 7590751)1, 2, 3, 9 O'Dowd B.F.... George S.R. (1995)
- Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3 Brezillon S.... Parmentier M. (2003)
- Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PubMed id 12719537)1, 2 Tanaka H.... Yanagisawa M. (2003)
- G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PubMed id 15797961)1, 9 Mazzocchi G....Nussdorfer G.G. (2005)
- A single nucleotide polymorphism of the neuropeptide B /W receptor-1 gene influences the evaluation of facial expressions. (PubMed id 22545105)1 Watanabe N....Yamamoto M. (2012)
- Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. (PubMed id 17437806)1 Cottrell S....Weiss G. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. (PubMed id 15607941)1 Zaratin P.F....Scheideler M.A. (2005)
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External Searches for NPBWR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPBWR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPBWR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPBWR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPBWR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPBWR1 gene:
Search GeneIP for patents involving NPBWR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPBWR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPBWR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPBWR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPBWR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPBWR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPBWR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPBWR1 |
| |
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| |  |  |  |  | | | | |
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 | | | NPBWR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPBWR1 |
|  |  |  | | | | ThermoFisher Antibodies for NPBWR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPBWR1 |
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