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Aliases for NPBWR1 Gene

Aliases for NPBWR1 Gene

  • Neuropeptides B And W Receptor 1 2 3 5
  • Neuropeptides B/W Receptor 1 2 3
  • G-Protein Coupled Receptor 7 3 4
  • GPR7 3 4
  • Opioid-Somatostatin-Like Receptor 7 3
  • Neuropeptides B/W Receptor Type 1 3
  • G Protein-Coupled Receptor 7 2
  • Neuropeptide B/W Receptor 1 3

External Ids for NPBWR1 Gene

Previous HGNC Symbols for NPBWR1 Gene

  • GPR7

Previous GeneCards Identifiers for NPBWR1 Gene

  • GC08P054014
  • GC08P053850
  • GC08P049319

Summaries for NPBWR1 Gene

GeneCards Summary for NPBWR1 Gene

NPBWR1 (Neuropeptides B And W Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPBWR2.

UniProtKB/Swiss-Prot for NPBWR1 Gene

  • Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Gene Wiki entry for NPBWR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPBWR1 Gene

Genomics for NPBWR1 Gene

Regulatory Elements for NPBWR1 Gene

Enhancers for NPBWR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G052693 1.6 FANTOM5 Ensembl ENCODE 5.5 -243.3 -243284 2.7 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS RB1CC1 ST18 NPBWR1 LOC105375835 ALKAL1
GH08G052824 0.7 ENCODE 9.9 -112.9 -112889 1.5 JUN CEBPB RAD21 EP300 RFX5 JUND MAFF RCOR1 FOS NFE2 NPBWR1 RB1CC1
GH08G052817 1 ENCODE 5.9 -119.4 -119387 2.6 ATF1 FOXA2 ARID4B TCF12 ZNF766 FOS KAT8 MEF2D NFIL3 SMARCA4 NPBWR1 RB1CC1
GH08G052763 1 Ensembl ENCODE 4.8 -174.0 -173966 1.6 GTF2F1 TAF1 JUN MAX GATA2 FOSL2 FOS NFE2L2 CHD2 TCF7L2 NPBWR1 RB1CC1
GH08G052793 0.5 ENCODE 5.6 -145.1 -145096 0.2 PKNOX1 RAD51 USF1 FOS NPBWR1 RB1CC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPBWR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NPBWR1 Gene

Chromosome:
8
Start:
52,938,431 bp from pter
End:
52,941,117 bp from pter
Size:
2,687 bases
Orientation:
Plus strand

Genomic View for NPBWR1 Gene

Genes around NPBWR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPBWR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPBWR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPBWR1 Gene

Proteins for NPBWR1 Gene

  • Protein details for NPBWR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48145-NPBW1_HUMAN
    Recommended name:
    Neuropeptides B/W receptor type 1
    Protein Accession:
    P48145
    Secondary Accessions:
    • Q6NTC7

    Protein attributes for NPBWR1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPBWR1 Gene

Post-translational modifications for NPBWR1 Gene

  • Glycosylation at Asn3, Asn13, and Asn25
  • Modification sites at PhosphoSitePlus

Other Protein References for NPBWR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPBWR1 Gene

Domains & Families for NPBWR1 Gene

Gene Families for NPBWR1 Gene

Protein Domains for NPBWR1 Gene

Suggested Antigen Peptide Sequences for NPBWR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48145

UniProtKB/Swiss-Prot:

NPBW1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPBWR1: view

Function for NPBWR1 Gene

Molecular function for NPBWR1 Gene

UniProtKB/Swiss-Prot Function:
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Gene Ontology (GO) - Molecular Function for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004985 opioid receptor activity TAS 7590751
GO:0005515 protein binding IPI 12401809
GO:0008188 neuropeptide receptor activity IEA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with NPBWR1: view
genes like me logo Genes that share phenotypes with NPBWR1: view

Animal Models for NPBWR1 Gene

MGI Knock Outs for NPBWR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPBWR1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPBWR1 Gene

Localization for NPBWR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPBWR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPBWR1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC 12401809
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with NPBWR1: view

Pathways & Interactions for NPBWR1 Gene

genes like me logo Genes that share pathways with NPBWR1: view

Pathways by source for NPBWR1 Gene

Gene Ontology (GO) - Biological Process for NPBWR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 12401809
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission TAS 7590751
genes like me logo Genes that share ontologies with NPBWR1: view

No data available for SIGNOR curated interactions for NPBWR1 Gene

Drugs & Compounds for NPBWR1 Gene

(10) Drugs for NPBWR1 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I][Tyr<sup>11</sup>]des-Br-NPB-23 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]NPW-23 (human) Pharma Agonist 0
Ava3 Pharma Full agonist, Agonist 0
Ava5 Pharma Full agonist, Agonist 0
des-Br-neuropeptide B-23 Pharma Full agonist, Agonist 0

(1) ApexBio Compounds for NPBWR1 Gene

Compound Action Cas Number
Neuropeptide W-23 (human) 383415-79-0
genes like me logo Genes that share compounds with NPBWR1: view

Drug Products

Transcripts for NPBWR1 Gene

mRNA/cDNA for NPBWR1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPBWR1 Gene

Neuropeptides B/W receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPBWR1 Gene

No ASD Table

Relevant External Links for NPBWR1 Gene

GeneLoc Exon Structure for
NPBWR1
ECgene alternative splicing isoforms for
NPBWR1

Expression for NPBWR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPBWR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPBWR1 Gene

This gene is overexpressed in Liver (x7.9), Skin - Not Sun Exposed (Suprapubic) (x5.4), Brain - Hypothalamus (x4.6), Brain - Anterior cingulate cortex (BA24) (x4.4), and Pituitary (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of NPBWR1 Gene:

NPBWR1

SOURCE GeneReport for Unigene cluster for NPBWR1 Gene:

Hs.248117

mRNA Expression by UniProt/SwissProt for NPBWR1 Gene:

P48145-NPBW1_HUMAN
Tissue specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
genes like me logo Genes that share expression patterns with NPBWR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPBWR1 Gene

Orthologs for NPBWR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPBWR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPBWR1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia NPBWR1 34 35
  • 88.52 (n)
cow
(Bos Taurus)
Mammalia NPBWR1 34 35
  • 88.41 (n)
rat
(Rattus norvegicus)
Mammalia Npbwr1 34
  • 83.69 (n)
mouse
(Mus musculus)
Mammalia Npbwr1 34 16 35
  • 82.98 (n)
oppossum
(Monodelphis domestica)
Mammalia NPBWR1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPBWR1 34 35
  • 65.65 (n)
lizard
(Anolis carolinensis)
Reptilia NPBWR1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia npbwr1 34
  • 67.14 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC556451 34
  • 63.85 (n)
CABZ01043829.1 35
  • 35 (a)
ManyToMany
Species where no ortholog for NPBWR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPBWR1 Gene

ENSEMBL:
Gene Tree for NPBWR1 (if available)
TreeFam:
Gene Tree for NPBWR1 (if available)

Paralogs for NPBWR1 Gene

Paralogs for NPBWR1 Gene

genes like me logo Genes that share paralogs with NPBWR1: view

Variants for NPBWR1 Gene

Sequence variations from dbSNP and Humsavar for NPBWR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035765 A breast cancer sample
rs1000264288 -- 52,939,117(+) AGACC(A/G/T)TTTTA upstream-variant-2KB
rs1000614739 -- 52,938,846(+) GATTT(C/G)CATTA upstream-variant-2KB
rs1000792211 -- 52,940,343(+) CGCGC(C/G)GGGTG reference, missense
rs1001387605 -- 52,939,442(+) CACTG(A/C)GGGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPBWR1 Gene

Variant ID Type Subtype PubMed ID
dgv7218n100 CNV gain 25217958
dgv7222n100 CNV gain 25217958
esv2759615 CNV gain+loss 17122850
esv2764065 CNV gain 21179565
esv3576572 CNV gain 25503493
esv3617224 CNV gain 21293372
esv3617225 CNV gain 21293372
esv3891397 CNV gain 25118596
nsv1016224 CNV gain 25217958
nsv1016750 CNV gain 25217958
nsv1023316 CNV gain 25217958
nsv1032190 CNV gain 25217958
nsv525238 CNV gain 19592680
nsv824633 CNV gain 20364138
nsv8344 CNV loss 18304495

Variation tolerance for NPBWR1 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPBWR1 Gene

Human Gene Mutation Database (HGMD)
NPBWR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPBWR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPBWR1 Gene

Disorders for NPBWR1 Gene

Relevant External Links for NPBWR1

Genetic Association Database (GAD)
NPBWR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPBWR1

No disorders were found for NPBWR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPBWR1 Gene

Publications for NPBWR1 Gene

  1. The cloning and chromosomal mapping of two novel human opioid- somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. (PMID: 7590751) O'Dowd B.F. … George S.R. (Genomics 1995) 2 3 4 22 64
  2. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 64
  3. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PMID: 15797961) Mazzocchi G. … Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005) 3 22 64
  4. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. (PMID: 12719537) Tanaka H. … Yanagisawa M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3 64

Products for NPBWR1 Gene

Sources for NPBWR1 Gene

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