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Aliases for NPB Gene

Aliases for NPB Gene

  • Neuropeptide B 2 3
  • Preproprotein L7 3 4
  • Prepro-NPB 2 3
  • PPNPB 3 4
  • PPL7 3 4
  • Preproneuropeptide B 3
  • HPPL7 4
  • L7 3

External Ids for NPB Gene

Summaries for NPB Gene

Entrez Gene Summary for NPB Gene

  • Neuropeptide B (NPB) is an endogenous peptide ligand for G protein-coupled receptor-7 (GPR7; MIM 600730).[supplied by OMIM, Apr 2004]

GeneCards Summary for NPB Gene

NPB (Neuropeptide B) is a Protein Coding gene. Diseases associated with NPB include colorectal adenocarcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for NPB Gene

  • May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPB Gene

Genomics for NPB Gene

Genomic Location for NPB Gene

Start:
81,900,745 bp from pter
End:
81,902,905 bp from pter
Size:
2,161 bases
Orientation:
Plus strand

Genomic View for NPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPB Gene

Regulatory Elements for NPB Gene

Transcription factor binding sites by QIAGEN in the NPB gene promoter:

Proteins for NPB Gene

  • Protein details for NPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG41-NPB_HUMAN
    Recommended name:
    Neuropeptide B
    Protein Accession:
    Q8NG41
    Secondary Accessions:
    • A0AUX9
    • A6NJD6
    • B9EJC3

    Protein attributes for NPB Gene

    Size:
    125 amino acids
    Molecular mass:
    13097 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPB Gene

Proteomics data for NPB Gene at MOPED

Post-translational modifications for NPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NPB Gene

Domains for NPB Gene

Gene Families for NPB Gene

HGNC:

Protein Domains for NPB Gene

UniProtKB/Swiss-Prot:

NPB_HUMAN
Family:
  • Belongs to the neuropeptide B/W family.:
    • Q8NG41
genes like me logo Genes that share domains with NPB: view

Function for NPB Gene

Molecular function for NPB Gene

UniProtKB/Swiss-Prot Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Gene Ontology (GO) - Molecular Function for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005515 protein binding IPI 12118011
genes like me logo Genes that share ontologies with NPB: view
genes like me logo Genes that share phenotypes with NPB: view

Animal Models for NPB Gene

MGI Knock Outs for NPB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NPB Gene

Localization for NPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NPB Gene COMPARTMENTS Subcellular localization image for NPB gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPB: view

Pathways for NPB Gene

genes like me logo Genes that share pathways with NPB: view

Gene Ontology (GO) - Biological Process for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12118011
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPB: view

Transcripts for NPB Gene

mRNA/cDNA for NPB Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPB Gene

Neuropeptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPB Gene

No ASD Table

Relevant External Links for NPB Gene

GeneLoc Exon Structure for
NPB
ECgene alternative splicing isoforms for
NPB

Expression for NPB Gene

mRNA expression in normal human tissues for NPB Gene

mRNA expression in normal human tissues for NPB Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NPB Gene

SOURCE GeneReport for Unigene cluster for NPB Gene Hs.708916

mRNA Expression by UniProt/SwissProt for NPB Gene

Q8NG41-NPB_HUMAN
Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma
genes like me logo Genes that share expressions with NPB: view

Orthologs for NPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPB 36
  • 81.33 (n)
  • 70 (a)
NPB 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NPB 36
  • 83.89 (n)
  • 75 (a)
NPB 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Npb 36
  • 72.85 (n)
  • 61.86 (a)
Npb 16
Npb 37
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NPB 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npb 36
  • 70.67 (n)
  • 60 (a)
chicken
(Gallus gallus)
Aves NPB 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPB 37
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii npb 37
  • 44 (a)
OneToOne
Species with no ortholog for NPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPB Gene

ENSEMBL:
Gene Tree for NPB (if available)
TreeFam:
Gene Tree for NPB (if available)

Paralogs for NPB Gene

No data available for Paralogs for NPB Gene

Variants for NPB Gene

Sequence variations from dbSNP and Humsavar for NPB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs35108745 -- 81,902,079(+) CTCCA(-/GC)GCTCG upstream-variant-2KB
rs35175733 -- 81,901,403(+) AGTGA(C/T)AATAC upstream-variant-2KB
rs112561300 -- 81,901,442(+) CACTC(A/G)GCATT upstream-variant-2KB
rs113089705 -- 81,901,996(+) GCCGG(G/T)CCTGA upstream-variant-2KB
rs138813198 -- 81,901,979(+) CACTG(A/C)GGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPB Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407

Relevant External Links for NPB Gene

HapMap Linkage Disequilibrium report
NPB

Disorders for NPB Gene

(1) University of Copenhagen DISEASES for NPB Gene

(1) Novoseek inferred disease relationships for NPB Gene

Disease -log(P) Hits PubMed IDs
obesity 26.9 1
genes like me logo Genes that share disorders with NPB: view

No data available for UniProtKB/Swiss-Prot for NPB Gene

Publications for NPB Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PMID: 12118011) Fujii R. … Fujino M. (J. Biol. Chem. 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3
  5. Dissociation of heterotrimeric g proteins in cells. (PMID: 18577758) Lambert N.A. (Sci Signal 2008) 3

Products for NPB Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NPB
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NPB
    • Block miRNA regulation of NPB using miScript Target Protectors

    Sources for NPB Gene

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