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Aliases for NPB Gene

Aliases for NPB Gene

  • Neuropeptide B 2 3 5
  • Preproprotein L7 3 4
  • Prepro-NPB 2 3
  • PPNPB 3 4
  • PPL7 3 4
  • Preproneuropeptide B 3
  • HPPL7 4
  • L7 3

External Ids for NPB Gene

Previous GeneCards Identifiers for NPB Gene

  • GC17P079351
  • GC17P9I0163
  • GC17P080395
  • GC17P077453
  • GC17P079860
  • GC17P075261

Summaries for NPB Gene

Entrez Gene Summary for NPB Gene

  • This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

GeneCards Summary for NPB Gene

NPB (Neuropeptide B) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for NPB Gene

  • May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPB Gene

Genomics for NPB Gene

Regulatory Elements for NPB Gene

Enhancers for NPB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G081682 1.1 ENCODE 11.3 -216.6 -216591 3.5 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS SP3 ARL16 ALYREF CCDC137 PDE6G NPLOC4 TSPAN10 P4HB GCGR MCRIP1 PPP1R27
GH17G081984 0.9 FANTOM5 11.7 +84.2 84164 0.2 MXI1 KLF1 ESRRA NFIB ZSCAN4 INSM2 GLI4 CDC5L ZNF2 ZFHX2 MYADML2 ENSG00000235296 PYCR1 MAFG SIRT7 PCYT2 NPB ANAPC11 ALYREF DCXR
GH17G082011 0.9 ENCODE 11.5 +112.7 112713 3.3 ELF3 ARID4B THRB RAD21 RARA GLIS2 ZNF143 PCBP1 PAF1 ZNF263 CENPX DCXR ASPSCR1 MYADML2 PYCR1 ENSG00000235296 MAFG SIRT7 PCYT2 NPB
GH17G081980 0.8 ENCODE 11.7 +80.2 80170 1.3 HDAC1 ESRRA TFAP4 FOXA2 ZIC2 HIC1 GATA3 FOS NR2F6 HES1 MYADML2 ENSG00000235296 PYCR1 MAFG SIRT7 PCYT2 NPB ALYREF ANAPC11 DCXR
GH17G081681 0.7 ENCODE 11.2 -219.1 -219110 0.9 HLF ZBTB8A ZIC2 OSR2 NFIL3 GLIS2 ZNF629 GLIS1 ZNF600 SP7 ARL16 NPLOC4 TSPAN10 GCGR MCRIP1 PPP1R27 ALYREF ANAPC11 NPB PCYT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NPB on UCSC Golden Path with GeneCards custom track

Promoters for NPB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099498 4 401 RB1 FUS AGO1 CCNT2 GLIS2 GATA4 EGR1 POLR2A KLF13 EZH2

Transcription factor binding sites by QIAGEN in the NPB gene promoter:

Genomic Location for NPB Gene

Chromosome:
17
Start:
81,900,745 bp from pter
End:
81,902,905 bp from pter
Size:
2,161 bases
Orientation:
Plus strand

Genomic View for NPB Gene

Genes around NPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPB Gene

Proteins for NPB Gene

  • Protein details for NPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG41-NPB_HUMAN
    Recommended name:
    Neuropeptide B
    Protein Accession:
    Q8NG41
    Secondary Accessions:
    • A0AUX9
    • A6NJD6
    • B9EJC3

    Protein attributes for NPB Gene

    Size:
    125 amino acids
    Molecular mass:
    13097 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPB Gene

Post-translational modifications for NPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPB Gene

Domains & Families for NPB Gene

Gene Families for NPB Gene

Protein Domains for NPB Gene

Suggested Antigen Peptide Sequences for NPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG41

UniProtKB/Swiss-Prot:

NPB_HUMAN :
  • Belongs to the neuropeptide B/W family.
Family:
  • Belongs to the neuropeptide B/W family.
genes like me logo Genes that share domains with NPB: view

Function for NPB Gene

Molecular function for NPB Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Gene Ontology (GO) - Molecular Function for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005515 protein binding IPI 12118011
genes like me logo Genes that share ontologies with NPB: view
genes like me logo Genes that share phenotypes with NPB: view

Animal Models for NPB Gene

MGI Knock Outs for NPB:

Animal Model Products

  • Taconic Biosciences Mouse Models for NPB

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPB Gene

Localization for NPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPB gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPB: view

Pathways & Interactions for NPB Gene

genes like me logo Genes that share pathways with NPB: view

Gene Ontology (GO) - Biological Process for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 12118011
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPB: view

No data available for SIGNOR curated interactions for NPB Gene

Transcripts for NPB Gene

mRNA/cDNA for NPB Gene

Unigene Clusters for NPB Gene

Neuropeptide B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPB Gene

No ASD Table

Relevant External Links for NPB Gene

GeneLoc Exon Structure for
NPB
ECgene alternative splicing isoforms for
NPB

Expression for NPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPB Gene

mRNA expression in normal human tissues for NPB Gene

Protein differential expression in normal tissues from HIPED for NPB Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPB Gene



Protein tissue co-expression partners for NPB Gene

NURSA nuclear receptor signaling pathways regulating expression of NPB Gene:

NPB

SOURCE GeneReport for Unigene cluster for NPB Gene:

Hs.708916

mRNA Expression by UniProt/SwissProt for NPB Gene:

Q8NG41-NPB_HUMAN
Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.
genes like me logo Genes that share expression patterns with NPB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPB Gene

Orthologs for NPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NPB 34 35
  • 83.89 (n)
cow
(Bos Taurus)
Mammalia NPB 34 35
  • 81.33 (n)
mouse
(Mus musculus)
Mammalia Npb 34 16 35
  • 72.85 (n)
rat
(Rattus norvegicus)
Mammalia Npb 34
  • 70.67 (n)
oppossum
(Monodelphis domestica)
Mammalia NPB 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPB 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPB 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii npb 35
  • 44 (a)
OneToOne
Species where no ortholog for NPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPB Gene

ENSEMBL:
Gene Tree for NPB (if available)
TreeFam:
Gene Tree for NPB (if available)

Paralogs for NPB Gene

No data available for Paralogs for NPB Gene

Variants for NPB Gene

Sequence variations from dbSNP and Humsavar for NPB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000430804 -- 81,902,767(+) CTGGC(A/G)CCGCT downstream-variant-500B, utr-variant-3-prime
rs1000839613 -- 81,901,539(+) AGACA(C/T)GACCA upstream-variant-2KB, utr-variant-3-prime
rs1001118847 -- 81,901,763(+) CCCTG(C/T)TGGTG upstream-variant-2KB, utr-variant-3-prime
rs1002197257 -- 81,902,296(+) CGACA(C/T)TGGCG reference, synonymous-codon, utr-variant-3-prime
rs1002247141 -- 81,901,879(+) GGCAC(-/TG)TGCAG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NPB Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for NPB Gene

Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPB Gene

Disorders for NPB Gene

Relevant External Links for NPB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NPB

No disorders were found for NPB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPB Gene

Publications for NPB Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S. … Parmentier M. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PMID: 12118011) Fujii R. … Fujino M. (J. Biol. Chem. 2002) 2 3 4 64
  3. Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PMID: 17486669) Kanesaka M. … Tokita S. (J. Pept. Sci. 2007) 3 22 64
  4. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G. … Davenport A.P. (Br. J. Pharmacol. 2006) 3 22 64
  5. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PMID: 15797961) Mazzocchi G. … Nussdorfer G.G. (J. Clin. Endocrinol. Metab. 2005) 3 22 64

Products for NPB Gene

Sources for NPB Gene

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