NPB Gene
protein-coding GIFtS: 49
GCID: GC17P079860
|
|
neuropeptide B
| |
Aliases
for NPB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuropeptide B1 2 | | L72 | | PPL71 2 3 | | Preproneuropeptide B2 | | PPNPB1 2 3 | | HPPL71 | | Preproprotein L72 3 | | |
Export aliases for NPB gene to outside databasesPrevious GC identifers: GC17P079351 GC17P9I0163 GC17P080395 GC17P077453 GC17P075261 |
Summaries
for NPB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NPB:
Neuropeptide B (NPB) is an endogenous peptide ligand for G protein-coupled receptor-7 (GPR7; MIM 600730).(supplied byOMIM, Apr 2004)
UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferentpain pathway (By similarity)
|
Genomic Views
for NPB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NPB gene promoter:
ATF-2 MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for NPB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3NPB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079860: view genomic region
(about GC identifiers)
Start:
|
79,858,621 bp from pter |
End:
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79,860,781 bp from pter |
Size:
|
2,161 bases |
Orientation:
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plus strand |
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Proteins
for NPB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41 (See
protein sequence)Recommended Name: Neuropeptide B precursor Size: 125 amino acids; 13097 Da
Subcellular location: Secreted
Secondary accessions: A0AUX9 A6NJD6 B9EJC3Explore the universe of human proteins at neXtProt for NPB: NX_Q8NG41
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NG41
NPB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_683694.1
ENSEMBL proteins: ENSP00000461824 ENSP00000332766 Reactome Protein details: Q8NG41
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
NPB for ontologies About GeneDecksing
NPB Antibody Products:
Assay Products for NPB: |
Protein
Domains /
Families
for NPB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NPB for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NG41ProtoNet protein and cluster: Q8NG41 UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41Similarity: Belongs to the neuropeptide B/W family |
Function
for NPB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferentpain pathway (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NPB (NM_001810) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NPB for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Npbtm1Ywa for NPB
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Npb):
NPB for phenotypes About GeneDecksing
|
Pathways & Interactions
for NPB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NPB
5/7 
Reactome Pathways for NPB (see all 7)
NPB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/143 Interacting proteins for NPB (Q8NG413 ENSP000003327664) via UniProtKB, MINT, STRING, and/or I2D (see all 143)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
IDA | 12118011 | | GO:0007218 | neuropeptide signaling pathway |
IEA | -- |
NPB for ontologies About GeneDecksing
|
Drugs & Compounds
for NPB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NPB
Search CenterWatch for drugs/clinical trials and news about NPB
|
Transcripts
for NPB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NPB gene: NM_148896.3 Unigene Cluster for NPB: Neuropeptide B Hs.708916 Unigene Representative Sequence: BC0331732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000573081 ENST00000333383(uc002kcd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NPB (NM_001810) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NPB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB |
Additional cDNA sequence: AB085942.1 AF525737.1 BC033173.1 BC126128.1 BC126485.1 BC146875.1 BC146890.1 2 DOTS entries: DT.70101052 DT.100800423 6 AceView cDNA sequences: AB085942 NM_148896 AW517217 AI394669 AW166253 AF525737
GeneLoc Exon Structure
|
Expression
for NPB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCGGTCCG
About this image
See NPB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPB
SOURCE GeneReport for Unigene cluster: Hs.708916
UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra,hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary.Also detected at high levels in colorectal adenocarcinoma
SABiosciences Custom PCR Arrays for NPB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPB
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NPB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPB |
Orthologs
for NPB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NPB gene from 4/8 species (see all 8) About this table
ENSEMBL Gene Tree for NPB (if available)
TreeFam Gene Tree for NPB (if available) |
Paralogs
for NPB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NPB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NPB (79858621 - 79860781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for NPB
5 CNVs: 23319 30036 7175 73078 5041 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPB |
|
Disorders
/ Diseases
for NPB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NPB for disorders About GeneDecksing
OMIM gene information: 607996
OMIM disorders: --
8  diseases for NPB: About MalaCardsniemann-pick disease pick's disease eating disorder adrenocortical carcinoma
obesity adenocarcinoma carcinoma neuronitis
1 disease from the University of Copenhagen DISEASES database for NPB:Niemann-Pick disease 1 Novoseek disease relationship for NPB gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| obesity |
26.9 |
1 |
16847439 (1) |
Export disorders for NPB gene to outside databases
|
Publications
for NPB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NPB gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with NPB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3, 9 Brezillon S.... Parmentier M. (2003)
- Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PubMed id 12118011)1, 2, 3 Fujii R....Fujino M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PubMed id 17486669)9 Kanesaka M....Tokita S. (2007)
- NMR conformational analyses on (des-bromo) neuropeptide B [1-23] and neuropeptide W [1-23]: the importance of alpha-helices, a cation-pi interaction and a beta-turn. (PubMed id 15918679)9 Lucyk S....Kotovych G. (2005)
|
External Searches for NPB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NPB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NPB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NPB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NPB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NPB gene:
Search GeneIP for patents involving NPB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NPB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NPB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NPB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NPB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NPB | | OriGene Custom Protein Services for NPB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NPB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPB |
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 |  |  |  | |
| | | | Search Tocris compounds for NPB |
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 | | | NPB Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for NPB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB |
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