Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPB Gene

protein-coding   GIFtS: 48
GCID: GC17P079860

Neuropeptide B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuropeptide B1 2     PPNPB2 3
prepro-NPB1 2     L72
Preproprotein L72 3     Preproneuropeptide B2
PPL72 3     hPPL73

External Ids:    HGNC: 300991   Entrez Gene: 2569332   Ensembl: ENSG000001839797   OMIM: 6079965   UniProtKB: Q8NG413   

Export aliases for NPB gene to outside databases

Previous GC identifers: GC17P079351 GC17P9I0163 GC17P080395 GC17P077453 GC17P075261


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPB Gene:
Neuropeptide B (NPB) is an endogenous peptide ligand for G protein-coupled receptor-7 (GPR7; MIM 600730).(supplied
by OMIM, Apr 2004)

GeneCards Summary for NPB Gene: 
NPB (neuropeptide B) is a protein-coding gene. Diseases associated with NPB include adrenocortical carcinoma, and niemann-pick disease, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include protein binding and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41
Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the
afferent pain pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPB gene promoter:
         ATF-2   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPB promoter sequence
   Search SABiosciences Chromatin IP Primers for NPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079860:  view genomic region     (about GC identifiers)

Start:
79,858,621 bp from pter      End:
79,860,781 bp from pter
Size:
2,161 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41 (See protein sequence)
Recommended Name: Neuropeptide B precursor  
Size: 125 amino acids; 13097 Da
Subcellular location: Secreted
Secondary accessions: A0AUX9 A6NJD6 B9EJC3

Explore the universe of human proteins at neXtProt for NPB: NX_Q8NG41

Explore proteomics data for NPB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NG41

  • NPB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPB Protein Expression
    REFSEQ proteins: NP_683694.1  
    ENSEMBL proteins: 
     ENSP00000461824   ENSP00000332766  
    Reactome Protein details: Q8NG41
    Human Recombinant Protein Products for NPB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NPB
    GenScript Custom Purified and Recombinant Proteins Services for NPB
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NPB 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    NPB for ontologies           About GeneDecksing



    NPB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NPB
    GenScript Custom Superior Antibodies Services for NPB
    Novus Biologicals NPB Antibody
    Search for Antibodies for NPB at Abcam
    Cloud-Clone Corp. Antibodies for NPB 
    ThermoFisher Antibody for NPB
    LSBio Antibodies in human, mouse, rat for NPB 

    Assay Products for NPB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NPB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NPB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NPB 
    Cloud-Clone Corp. CLIAs for NPB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR013297 Neuropept_BW_pre
     IPR013298 Neuropept_B_pre

    Graphical View of Domain Structure for InterPro Entry Q8NG41

    ProtoNet protein and cluster: Q8NG41

    UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41
    Similarity: Belongs to the neuropeptide B/W family


    NPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPB_HUMAN, Q8NG41
    Function: May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the
    afferent pain pathway (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IEA--
    GO:0005515protein binding IPI12118011
         
    NPB for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Npb):
     behavior/neurological  growth/size  integument 

    NPB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Npbtm1Ywa for NPB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NPB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NPB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NPB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NPB
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NPB
    Sirion Biotech Customized adenovirus for overexpression of NPB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NPB (see all 6)
    OriGene ORF clones in mouse, rat for NPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPB (NM_001810)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB
    Sirion Biotech Customized lentivirus for stable overexpression of NPB 
                         Customized lentivirus expression plasmids for stable overexpression of NPB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NPB
    Search LifeMap BioReagents cell lines for NPB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NPB
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    5/7        Reactome Pathways for NPB (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events



    NPB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for NPB (Q8NG413 ENSP000003327664) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NPBWR1P481453, ENSP000003302844I2D: score=2 STRING: ENSP00000330284
    NPBWR2P481463, ENSP000003587834I2D: score=1 STRING: ENSP00000358783
    ADCY2ENSP000003429524STRING: ENSP00000342952
    APLNRENSP000002572544STRING: ENSP00000257254
    GALENSP000002656434STRING: ENSP00000265643
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA12118011
    GO:0007218neuropeptide signaling pathway IEA--

    NPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPB

    Search CenterWatch for drugs/clinical trials and news about NPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPB gene: 
    NM_148896.3  

    Unigene Cluster for NPB:

    Neuropeptide B
    Hs.708916  [show with all ESTs]
    Unigene Representative Sequence: BC033173
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000573081 ENST00000333383(uc002kcd.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NPB
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPB
    Clone
    Products:
         
    OriGene clones in human, mouse for NPB (see all 6)
    OriGene ORF clones in mouse, rat for NPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NPB (NM_001810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB
    Sirion Biotech Customized lentivirus for stable overexpression of NPB 
                         Customized lentivirus expression plasmids for stable overexpression of NPB 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NPB
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NPB
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPB

    Additional mRNA sequence: 

    AB085942.1 AF525737.1 BC033173.1 BC126128.1 BC126485.1 BC146875.1 BC146890.1 

    2 DOTS entries:

    DT.70101052  DT.100800423 

    6 AceView cDNA sequences:

    AB085942 NM_148896 AI394669 AW517217 AW166253 AF525737 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCGGTCCG
    NPB Expression
    About this image


    See NPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPB

    SOURCE GeneReport for Unigene cluster: Hs.708916

    UniProtKB/Swiss-Prot: NPB_HUMAN, Q8NG41
    Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra,
    hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and
    ovary. Also detected at high levels in colorectal adenocarcinoma

        SABiosciences Custom PCR Arrays for NPB
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NPB
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NPB
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NPB gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npb1 , 5 neuropeptide B1, 5 74.04(n)1
    63.72(a)1
      11 (84.33 cM)5
    2089901  NM_153288.31  NP_695020.11 
     1206084775 
    chicken
    (Gallus gallus)
    Aves NPB6
    Uncharacterized protein
    43(a)
    1 ↔ 1
    18(10219885-10220906)
    lizard
    (Anolis carolinensis)
    Reptilia NPB6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    2(118553556-118553693)
    zebrafish
    (Danio rerio)
    Actinopterygii npb1 neuropeptide B 56.8(n)
    48(a)
      563766  NM_001127369.1  NP_001120841.1 


    ENSEMBL Gene Tree for NPB (if available)
    TreeFam Gene Tree for NPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/21 SNPs in NPB are shown (see all 21)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811737611,2
    --79858875(+) ACTCAC/GGTGAT 1 -- us2k10--------
    rs1861455941,2
    --79858905(+) ATAAGC/GCATGT 1 -- us2k10--------
    rs1909162671,2
    --79858924(+) AGGAGA/CAAGGA 1 -- us2k10--------
    rs1821182921,2
    --79858966(+) AAGCCA/GATAGT 1 -- us2k10--------
    rs1864366471,2
    --79859139(+) ACGTTC/TCTCTG 1 -- us2k10--------
    rs351757331,2
    C,F--79859279(+) AGTGAC/TAATAC 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1125613001,2
    C,F--79859318(+) CACTCG/AGCATT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1420465331,2
    --79859347(+) GCATGA/GAACCC 1 -- us2k10--------
    rs1908460681,2
    --79859391(+) TGTCCC/TGGGAA 1 -- us2k10--------
    rs1500428771,2
    C--79859446(+) ATGGTC/GAGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPB (79858621 - 79860781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for NPB (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    esv29964CNV Loss17803354
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3342n71CNV Loss21882294
    dgv3338n71CNV Loss21882294
    esv33468CNV Loss17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPB
    DNA2.0 Custom Variant and Variant Library Synthesis for NPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607996    OMIM disorders: --

    7 diseases for NPB:    About MalaCards
    adrenocortical carcinoma    niemann-pick disease    pick's disease    eating disorder
    obesity    adenocarcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NPB:
    Niemann-Pick disease

    NPB for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NPB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 26.9 1 16847439 (1)


    Export disorders for NPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPB gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PubMed id 12401809)1, 2, 3, 9 Brezillon S.... Parmentier M. (2003)
    2. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PubMed id 12118011)1, 2, 3 Fujii R....Fujino M. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (2008)
    5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    9. Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PubMed id 17486669)9 Kanesaka M....Tokita S. (2007)
    10. NMR conformational analyses on (des-bromo) neuropeptide B [1-23] and neuropeptide W [1-23]: the importance of alpha-helices, a cation-pi interaction and a beta-turn. (PubMed id 15918679)9 Lucyk S....Kotovych G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256933 HGNC: 30099 AceView: NPB.1 Ensembl:ENSG00000183979 euGenes: HUgn256933
    ECgene: NPB H-InvDB: NPB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPB gene:
    Search GeneIP for patents involving NPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NPB  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NPB  
     OriGene qSTAR qPCR primer pairs in human, mouse for NPB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NPB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NPB   OriGene Custom Protein Services for NPB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NPB
     QIAGEN SeqTarget long-range PCR primers for resequencing NPB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPB
     Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPB
     GenScript Custom Purified and Recombinant Proteins Services for NPB GenScript cDNA clones with any tag delivered in your preferred vector for NPB
     GenScript Custom Assay Services for NPB GenScript Custom Superior Antibodies Services for NPB
     GenScript Custom overexpressing Cell Line Services for NPB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NPB promoter
     Search Chromatin IP Primers for NPB
     Search RT2 qPCR Primer Assays in human, mouse, rat NPB
     Search GNC Networks for NPB
     SABiosciences Custom PCR Arrays for NPB
     Search Tocris compounds for NPB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NPB antibodies
     Search for Antibodies for NPB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NPB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NPB
     Antibodies for NPB
     ELISAs for NPB
     CLIAs for NPB
     Search LifeMap BioReagents cell lines for NPB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NPB
     SwitchGear Promoter luciferase reporter plasmids for NPB
     ThermoFisher Antibody for NPB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NPB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NPB
    Customized:
     lentivirus for stable overexpression of NPB
     lentivirus expression plasmids for stable overexpression of NPB
     adenovirus for overexpression of NPB
     LSBio Antibodies in human, mouse, rat for NPB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NPB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4