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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPAT Gene

protein-coding   GIFtS: 53
GCID: GC11M108062

nuclear protein, ataxia-telangiectasia locus
 Explore 7 diseases affiliated with
NPAT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NPAT    

Aliases
for NPAT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Protein, Ataxia-Telangiectasia Locus1 2     P2201
E141 2 3 5     E14/NPAT2
Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus2 3     Protein NPAT2
Nuclear Protein Of The ATM Locus2 3     CAND33

External Ids:    HGNC: 78961   Entrez Gene: 48632   Ensembl: ENSG000001493087   OMIM: 6014485   UniProtKB: Q142073   

Export aliases for NPAT gene to outside databases

Previous GC identifers: GC11M110222 GC11M109384 GC11M107565 GC11M107533 GC11M103953


Summaries
for NPAT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NPAT_HUMAN, Q14207
Function: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates
transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also
positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in
part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters

Gene Wiki entry for NPAT


Genomic Views
for NPAT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPAT gene promoter:
         c-Fos   TBP   RP58   AP-1   Sp1   GATA-3   CUTL1   MZF-1   TFIID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPAT promoter sequence
   Search SABiosciences Chromatin IP Primers for NPAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

NPAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M108062:  view genomic region     (about GC identifiers)

Start:
 108,027,942 bp from pter      End:
 108,093,369 bp from pter
Size:
 65,428 bases      Orientation:
 minus strand

Proteins
for NPAT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPAT_HUMAN, Q14207 (See protein sequence)
Recommended Name: Protein NPAT  
Size: 1427 amino acids; 154290 Da
Subunit: Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF
and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1,
NME2 and STIP1
Subcellular location: Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene
clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to
histone gene clusters at chromosome 1q21 specifically during S and G2 phases
Developmental stage: Expressed throughout the cell cycle. Expression peaks at the G1/S phase boundary and declines
during S phase
Sequence caution: Sequence=AAB02735.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating
from chromosomes 11 and 4; Sequence=AAH40356.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH50561.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
Secondary accessions: A8K1V5 A8K6M2 Q13632 Q14967 Q16580 Q86W55 Q8IWE9

Explore the universe of human proteins at neXtProt for NPAT: NX_Q14207

Post-translational modifications:

  • Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until
    • prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription.
    Also phosphorylated by CCNA1/CDK2 in vitro1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14207

    • NPAT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002510.2  
    ENSEMBL proteins: 
     ENSP00000278612   ENSP00000436510   ENSP00000433497  

    Human Recombinant Protein Products: 
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    Uscn Proteins for NPAT

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15988025
    GO:0015030Cajal body IDA15988025
    GO:0044428nuclear part IDA19170105


    NPAT for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NPAT

    Protein Domains /
    Families
    for NPAT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NPAT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006594 LisH_dimerisation

    Graphical View of Domain Structure for InterPro Entry Q14207

    ProtoNet protein and cluster: Q14207

    1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: NPAT_HUMAN, Q14207
    Domain: The LisH domain is required for the activation of histone gene transcription
    Similarity: Belongs to the NPAT family
    Similarity: Contains 1 LisH domain


    Function
    for NPAT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NPAT_HUMAN, Q14207
    Function: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates
    transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also
    positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in
    part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters
    Induction: By expression of E2F1, E2F2, E2F3 and E2F4. Expression is reduced in response to radiation-induced DNA
    damage

         Genatlas biochemistry entry for NPAT:
    nuclear protein,mapped upstream to the AT locus,in opposite orientation,likely transcribed from a bidirectional
    promoter,with homology

    miRNA
    Products:            		miRTarBase miRNAs that target NPAT:
    hsa-mir-17 (MIRT000261)

    OriGene 3'-UTR Clone: NPAT
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPAT
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate NPAT (see all 48):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-106a hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: NPAT 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPAT (see all 7)
    OriGene shRNA RFP: NPAT
    OriGene siRNA: NPAT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPAT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NPAT

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NPAT (see all 3)
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    Search LifeMap BioReagents cell lines for NPAT

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA18850719
    GO:0003713transcription coactivator activity IMP15988025
    GO:0003714transcription corepressor activity IMP17163457
    GO:0005515protein binding IPI18850719
    GO:0008022protein C-terminus binding IPI15988025


    NPAT for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NPAT:
     Increased S DNA content, incre  Increased gamma-H2AX phosphory  S arrest 


    Pathways & Interactions
    for NPAT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for NPAT (Q142073 ENSP000002786124) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    POU2F1P148593, ENSP000002714114I2D: score=2 STRING: ENSP00000271411
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    TRRAPQ9Y4A53, ENSP000003477334I2D: score=1 STRING: ENSP00000347733
    STIP1P319483, ENSP000003059584I2D: score=1 STRING: ENSP00000305958
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000083regulation of transcription involved in G1/S phase of mitotic cell cycle IMP15988025
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010468regulation of gene expression IMP15988025
    GO:0045893positive regulation of transcription, DNA-dependent IDA18850719


    NPAT for ontologies           About GeneDecksing



    Drugs & Compounds
    for NPAT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NPAT
    Search CenterWatch for drugs/clinical trials and news about NPAT 

    Transcripts
    for NPAT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NPAT gene: 
    NM_002519.2  

    Unigene Cluster for NPAT:

    Nuclear protein, ataxia-telangiectasia locus
    Hs.171061  [show with all ESTs]
    Unigene Representative Sequence: NM_002519
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278612(uc010rvv.2 uc001pjz.4) ENST00000530926 ENST00000530859
    ENST00000527296 ENST00000533535(uc001pka.3) ENST00000525615 ENST00000531384


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPAT
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate NPAT (see all 48):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-106a hsa-miR-301a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: NPAT 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPAT (see all 7)
    OriGene shRNA RFP: NPAT
    OriGene siRNA: NPAT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NPAT
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NPAT (NM_002519)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NPAT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NPAT 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NPAT
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NPAT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NPAT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPAT

    Additional cDNA sequence: 

    AK290020.1 AK291687.1 AK301256.1 BC040356.1 BC050561.2 BC094769.1 BC136270.1 D83243.1 
    U58852.1 X97186.1 

    11 DOTS entries:

    DT.213329  DT.100750015  DT.100781743  DT.100781744  DT.100007970  DT.120760373  DT.75169744  DT.92050432 
    DT.95265556  DT.95265560  DT.95288015 

    24/86 AceView cDNA sequences (see all 86):

    AI961122 AA292597 AA305136 AU120202 AU118596 BF109016 BC050561 AA419560 
    AW118709 BU657468 AA969959 AA284172 AI572283 BC040356 BX484956 CD642621 
    CD655125 D83243 BM968537 AU133314 R57983 BP378752 BF224010 BE550089 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NPAT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:              -                                                                             -                                                   
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                                -               


    ECgene alternative splicing isoforms for NPAT

    Expression
    for NPAT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTCTTAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NPAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPAT

    SOURCE GeneReport for Unigene cluster: Hs.171061

    UniProtKB/Swiss-Prot: NPAT_HUMAN, Q14207
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for NPAT
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPAT

    Orthologs
    for NPAT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NPAT gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Npat1 , 5 nuclear protein in the AT region1, 5 81.76(n)1
    75.51(a)1    		   9 (29.12 cM)5
    2448791  NM_001081152.11  NP_001074621.11 
     535370475 
    chicken
    (Gallus gallus)    		 Aves NPAT1 nuclear protein, ataxia-telangiectasia locus 61.06(n)
    52.95(a)    		   418967  XM_417161.3  XP_417161.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NPAT6
    		 --
    		 45(a)
    		 1 ↔ 1
    		 GL343659.1(264386-288607)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.82062 Transcribed sequence with weak similarity to protein more 75.41(n)    142020219 
    zebrafish
    (Danio rerio)    		 Actinopterygii npat1 nuclear protein, ataxia-telangiectasia locus 49.81(n)
    40.83(a)    		   552973  XM_685884.3  XP_690976.3 


    ENSEMBL Gene Tree for NPAT (if available)
    TreeFam Gene Tree for NPAT (if available) 

    Paralogs
    for NPAT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NPAT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1057 NCBI SNPs in NPAT are shown (see all 1057)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1913615111,2
    		--108027912(+) TAGCAG/TTTCCT 1 -- int10--------
    rs1162587751,2
    		F,--108028056(+) AGAACT/CGACTT 1 -- int11Minor allele frequency- C:0.05WA 118
    rs1817150871,2
    		--108028281(+) AATTAA/GGAAGA 1 -- ut310--------
    rs1869044011,2
    		--108028320(+) TTAAAA/GTTGGA 1 -- ut310--------
    rs1907347721,2
    		--108028419(+) TAATAC/TACTGA 1 -- ut310--------
    rs1832262831,2
    		--108028578(+) CACCTC/TTCTCA 1 -- ut310--------
    rs1438097711,2
    		--108028581(+) CTCTCC/TCATCT 1 -- ut310--------
    rs37589101,2
    		C,F,H,--108028670(-) ACTATA/GTCTAT 1 -- ut3111Minor allele frequency- G:0.07EA NS 2360
    rs1472369901,2
    		--108028691(+) ACCCAC/TTGTAG 1 -- ut310--------
    rs1879393211,2
    		--108028730(+) CTCTTC/TTTACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NPAT (108027942 - 108093369 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NPAT: --
    Human Gene Mutation Database (HGMD): NPAT

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NPAT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NPAT for disorders           About GeneDecksing

    OMIM gene information: 601448    OMIM disorders: --

    7 diseases for NPAT:    About MalaCards
    ataxia telangiectasia    ataxia    hodgkin's lymphoma    lissencephaly
    conjunctivitis    cervical cancer    cervicitis

    1 disease from the University of Copenhagen DISEASES database for NPAT:
    Ataxia telangiectasia

    1 Novoseek disease relationship for NPAT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0.395 2 16861913 (2)

    Human Genome Epidemiology (HuGE) Navigator: NPAT (5 documents)

    Export disorders for NPAT gene to outside databases

    Publications
    for NPAT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPAT gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with NPAT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The structure and organization of the human NPAT gene. (PubMed id 9205109)1, 2, 3 Imai T.... Hori T. (1997)
    2. NPAT expression is regulated by E2F and is essential for cell cycle progression. (PubMed id 12665581)1, 2, 9 Gao G.... Zhao J. (2003)
    3. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S- phase entry. (PubMed id 9472014)1, 2, 9 Zhao J.... Harlow E. (1998)
    4. Identification and characterization of a new gene physically linked to the ATM gene. (PubMed id 8743993)1, 2, 9 Imai T.... Hori T. (1996)
    5. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (PubMed id 10995386)1, 2, 9 Zhao J.... Harlow E. (2000)
    6. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. (PubMed id 12887926)1, 2, 9 Zheng L.... Luo Y. (2003)
    7. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. (PubMed id 17967892)1, 2 DeRan M.... Zhao J. (2008)
    8. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. (PubMed id 17974976)1, 2 Medina R.... Stein G.S. (2007)
    9. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. (PubMed id 17163457)1, 2 Mitra P....van Wijnen A.J. (2007)
    10. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. (PubMed id 15988025)1, 2 Miele A....Stein G.S. (2005)

    External Searches for NPAT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    OMIM
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    Genome Databases showing NPAT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4863 HGNC: 7896 AceView: NPAT Ensembl:ENSG00000149308 euGenes: HUgn4863
    ECgene: NPAT H-InvDB: NPAT

    Other Databases showing NPAT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NPAT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPAT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NPAT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NPAT gene:
    Search GeneIP for patents involving NPAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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