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NPAS3 Gene

protein-coding   GIFtS: 53
GCID: GC14P033408

Neuronal PAS Domain Protein 3

  See NPAS3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal PAS Domain Protein 31 2     PASD62 3
MOP62 3 5     bHLHe122 3
Basic-Helix-Loop-Helix-PAS Protein MOP62 3     PAS Domain-Containing Protein 62 3
Class E Basic Helix-Loop-Helix Protein 122 3     Neuronal PAS Domain-Containing Protein 32
Member Of PAS Protein 62 3     BHLHE123
Neuronal PAS32 3     

External Ids:    HGNC: 193111   Entrez Gene: 640672   Ensembl: ENSG000001513227   OMIM: 6094305   UniProtKB: Q8IXF03   

Export aliases for NPAS3 gene to outside databases

Previous GC identifers: GC14P030785 GC14P027195 GC14P031398 GC14P032478 GC14P013641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NPAS3 Gene:
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription
factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis.
Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and
mental retardation. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for NPAS3 Gene:
NPAS3 (neuronal PAS domain protein 3) is a protein-coding gene. Diseases associated with NPAS3 include esotropia, and learning disability. GO annotations related to this gene include protein dimerization activity and signal transducer activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: NPAS3_HUMAN, Q8IXF0
Function: May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to
psychotic illness (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NPAS3 gene promoter:
         GATA-3   NRSF form 1   MyoD   CUTL1   Tal-1beta   NRSF form 2   E47   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPAS3 promoter sequence
   Search Chromatin IP Primers for NPAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NPAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.1   Ensembl cytogenetic band:  14q13.1   HGNC cytogenetic band: 14q13.1

NPAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAS3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P033408:  view genomic region     (about GC identifiers)

Start:
33,404,139 bp from pter      End:
34,273,382 bp from pter
Size:
869,244 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NPAS3_HUMAN, Q8IXF0 (See protein sequence)
Recommended Name: Neuronal PAS domain-containing protein 3  
Size: 933 amino acids; 100805 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein
Secondary accessions: Q86US6 Q86US7 Q8IXF2 Q9BY81 Q9H323 Q9Y4L8
Alternative splicing: 6 isoforms:  Q8IXF0-1   Q8IXF0-2   Q8IXF0-3   Q8IXF0-4   Q8IXF0-5   Q8IXF0-6   

Explore the universe of human proteins at neXtProt for NPAS3: NX_Q8IXF0

Explore proteomics data for NPAS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NPAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001158221.1  NP_001159365.1  NP_071406.1  NP_775182.1  

    ENSEMBL proteins: 
     ENSP00000448373   ENSP00000450392   ENSP00000319610   ENSP00000448916   ENSP00000348460  
     ENSP00000350446   ENSP00000449542   ENSP00000447213   ENSP00000446700   ENSP00000447858  
     ENSP00000448450   ENSP00000344158  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    5 InterPro protein domains:
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom
     IPR013655 PAS_fold_3

    Graphical View of Domain Structure for InterPro Entry Q8IXF0

    ProtoNet protein and cluster: Q8IXF0

    4 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013655 PAS fold-3
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: NPAS3_HUMAN, Q8IXF0
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    Find genes that share domains with NPAS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPAS3_HUMAN, Q8IXF0
    Function: May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to
    psychotic illness (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with NPAS3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Npas3):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  respiratory system 

    Find genes that share phenotypes with NPAS3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NPAS3: Npas3tm1Slm Npas3tm1Ewb Npas3tm1Mesu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NPAS3
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    Selected qRT-PCR Assays for microRNAs that regulate NPAS3 (see all 169):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-3921 hsa-miR-342-3p hsa-miR-3916 hsa-miR-1273d hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNPAS3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NPAS3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NPAS3_HUMAN, Q8IXF0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NPAS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NPAS3
    Interactions:

        Search GeneGlobe Interaction Network for NPAS3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for NPAS3 (ENSP000003196104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARNTENSP000003514074STRING: ENSP00000351407
    ARNT2ENSP000003074794STRING: ENSP00000307479
    ARNTLENSP000003743574STRING: ENSP00000374357
    PTENENSP000003610214STRING: ENSP00000361021
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001964startle response IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction ----
    GO:0007626locomotory behavior IEA--

    Find genes that share ontologies with NPAS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NPAS3

    1 Novoseek inferred chemical compound relationship for NPAS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 0 1 17284606 (1)



    Find genes that share compounds with NPAS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NPAS3 gene (4 alternative transcripts): 
    NM_001164749.1  NM_001165893.1  NM_022123.2  NM_173159.2  

    Unigene Cluster for NPAS3:

    Neuronal PAS domain protein 3
    Hs.657892  [show with all ESTs]
    Unigene Representative Sequence: NM_001164749
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551634 ENST00000551492 ENST00000346562(uc001wru.3 uc001wrs.3 uc001wrv.3 uc001wrt.3)
    ENST00000548645 ENST00000356141 ENST00000357798 ENST00000547068(uc001wrw.3)
    ENST00000549770 ENST00000551008 ENST00000546849 ENST00000552696 ENST00000550662
    ENST00000552874 ENST00000341321
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    Selected qRT-PCR Assays for microRNAs that regulate NPAS3 (see all 169):
    hsa-miR-579 hsa-miR-106a hsa-miR-128 hsa-miR-3921 hsa-miR-342-3p hsa-miR-3916 hsa-miR-1273d hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidNPAS3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB054575.1 AB054576.1 AB055962.1 AF164438.1 AL079281.1 AY157302.1 AY157303.1 BC035075.1 

    8 DOTS entries:

    DT.75101499  DT.95261986  DT.100013827  DT.92045352  DT.100013826  DT.95329791  DT.100801938  DT.403509 

    Selected AceView cDNA sequences (see all 50):

    AW449952 AI089752 AI401348 AI619782 AB055962 CR597514 BE858756 AI652851 
    BX103395 BX431661 BF515828 AI769664 BX411361 BF196935 AI858643 AW188989 
    AI150583 AI085808 AI809984 BV205688 AI683866 AI885047 BX408489 BF111444 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NPAS3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                          -                 -                       -                                       
    SP2:                    -     -                                         -                                       
    SP3:                    -     -                 -                       -                                       
    SP4:                    -     -                 -                       -                                       
    SP5:                                            -                                                               


    ECgene alternative splicing isoforms for NPAS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NPAS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAAGACA
    NPAS3 Expression
    About this image


    NPAS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    NPAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NPAS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657892

    UniProtKB/Swiss-Prot: NPAS3_HUMAN, Q8IXF0
    Tissue specificity: Ubiquitously expressed in the adult brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NPAS3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npas31 , 5 neuronal PAS domain protein 31, 5 90.8(n)1
    96.36(a)1
      12 (22.31 cM)5
    273861  NM_013780.21  NP_038808.21 
     532486775 
    chicken
    (Gallus gallus)
    Aves NPAS31 neuronal PAS domain protein 3 82.88(n)
    93.61(a)
      423315  XM_421232.4  XP_421232.4 
    lizard
    (Anolis carolinensis)
    Reptilia NPAS36
    neuronal PAS domain protein 3
    91(a)
    1 ↔ 1
    2(55155095-55401980)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia npas31 neuronal PAS domain protein 3 72.96(n)
    81.34(a)
      780104  NM_001079179.1  NP_001072647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii npas31 neuronal PAS domain protein 3 72.72(n)
    77.73(a)
      570491  XM_003200316.2  XP_003200364.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta trh3 salivary gland morphogenesis
    transcription factor
    45(a)   3 61C1   --


    ENSEMBL Gene Tree for NPAS3 (if available)
    TreeFam Gene Tree for NPAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NPAS3 gene
    ARNT22  CLOCK2  NPAS22  AHR2  ARNT2  EPAS12  HIF1A2  SIM22  
    SIM12  HIF3A2  ARNTL2  NPAS12  ARNTL22  AHRR2  
    5 SIMAP similar genes for NPAS3 using alignment to 7 protein entries:     NPAS3_HUMAN (see all proteins):
    NPAS1    SIM2    EPAS1    HIF1A    HIF3A

    Find genes that share paralogs with NPAS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NPAS3 (see all 18468)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388422541,2
    --13523844(+) GTGACA/GTATCA 4 -- us2k10--------
    rs101305121,2
    C--13524000(+) GGGTGA/TCCTGG 4 -- us2k10--------
    rs1504539031,2
    C--13524180(+) ATTTAC/TGTGTT 4 -- us2k10--------
    rs1116633211,2
    C,F--13524297(+) CAGAAA/CCTCAC 4 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1171024701,2
    C,F--13524371(+) TTTCTA/GCTTGC 4 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1855974021,2
    --13524407(+) TCTCTC/GCGTAA 4 -- us2k10--------
    rs797899391,2
    C,F--13524555(+) GGTGCG/AGCTGG 4 -- us2k12Minor allele frequency- A:0.04CSA WA 119
    rs1895875471,2
    --13524620(+) GGGGCC/TTCTGT 4 -- us2k10--------
    rs65715741,2
    C,F,A,H--13524641(+) AAACGT/CGCGGG 4 -- us2k126Minor allele frequency- C:0.38NS EA NA WA CSA 2763
    rs1433759861,2
    C--13524745(+) CACAAA/GGTGCT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for NPAS3 (33404139 - 33654139 bp, first 250kb of NPAS3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NPAS3 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669699CNV Deletion23128226
    esv2748572CNV Deletion23290073
    esv1461660CNV Deletion17803354
    esv2268114CNV Deletion18987734
    esv2748575CNV Deletion23290073
    esv2748573CNV Deletion23290073
    esv2131914CNV Deletion18987734
    esv2748576CNV Deletion23290073
    esv2748577CNV Deletion23290073
    esv2662805CNV Deletion23128226

    Human Gene Mutation Database (HGMD): NPAS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NPAS3
    DNA2.0 Custom Variant and Variant Library Synthesis for NPAS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 609430    OMIM disorders: --

    UniProtKB/Swiss-Prot: NPAS3_HUMAN, Q8IXF0
  • Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation
    t(9;14)(q34;q13)

  • 3 diseases for NPAS3:    
    About MalaCards
    esotropia    learning disability    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for NPAS3:
    Schizophrenia

    Find genes that share disorders with NPAS3           About GenesLikeMe

    1 Novoseek inferred disease relationship for NPAS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 27.5 2 15924306 (1), 18521090 (1)

    Genetic Association Database (GAD): NPAS3
    Human Genome Epidemiology (HuGE) Navigator: NPAS3 (11 documents)

    Export disorders for NPAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NPAS3 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with NPAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. (PubMed id 12746393)1, 2, 9 Kamnasaran D.... Cox D.W. (J. Med. Genet. 2003)
    2. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. (PubMed id 18521090)1, 4, 9 Lavedan C....Polymeropoulos M.H. (Mol. Psychiatry 2009)
    3. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (Pharmacogenet. Genomics 2012)
    4. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PubMed id 20713499)1, 4 Huang J....Smoller J.W. (Am J Psychiatry 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. (PubMed id 19573479)1, 4 Volpi S....Lavedan C. (J Clin Psychiatry 2009)
    8. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    9. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1, 4 Ferreira M.A....Craddock N. (Nat. Genet. 2008)
    10. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. (PubMed id 18195134)1, 9 Byun E....Oksenberg J.R. (Arch. Neurol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64067 HGNC: 19311 AceView: NPAS3 Ensembl:ENSG00000151322 euGenes: HUgn64067
    ECgene: NPAS3 H-InvDB: NPAS3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NPAS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NPAS3 gene:
    Search GeneIP for patents involving NPAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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