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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NPAS2 Gene

protein-coding GIFtS: 61
GCID: GC02P101436

neuronal PAS domain protein 2

Explore 16 diseases affiliated with
NPAS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuronal PAS Domain Protein 2¹ ²		Member Of PAS Protein 4² ³
MOP4¹ ² ³ ⁵		Neuronal PAS2² ³
PASD4¹ ² ³		PAS Domain-Containing Protein 4² ³
BHLHe9¹		Member Of PAS Superfamily 4²
Basic-Helix-Loop-Helix-PAS Protein MOP4² ³		Neuronal PAS Domain-Containing Protein 2²
Class E Basic Helix-Loop-Helix Protein 9² ³		BHLHE9³

External Ids:	HGNC: 7895¹	Entrez Gene: 4862²	Ensembl: ENSG00000170485⁷	OMIM: 603347⁵	UniProtKB: Q99743³

Export aliases for NPAS2 gene to outside databases

Previous GC identifers: GC02P099300 GC02P099889 GC02P101041 GC02P101058 GC02P100895 GC02P100803 GC02P095284

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPAS2:

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors.

A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may

function as a part of a molecular clock operative in the mammalian forebrain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Function: BMAL1-NPAS2 heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Gene Wiki entry for NPAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NPAS2 gene promoter:
AML1a C/EBPalpha Evi-1 HNF-1A CP2 HNF-1 POU2F1a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NPAS2 promoter sequence

Search SABiosciences Chromatin IP Primers for NPAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2

NPAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAS2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P101436: view genomic region (about GC identifiers)

Start:	101,436,613 bp from pter	End:	101,613,291 bp from pter
Size:	176,679 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743 (See protein sequence)

Recommended Name: Neuronal PAS domain-containing protein 2

Size: 824 amino acids; 91791 Da

Subunit: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2,

CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH

protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q4ZFV9 Q53SQ3 Q86V96 Q99629

Explore the universe of human proteins at neXtProt for NPAS2: NX_Q99743

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99743

NPAS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002509.2

ENSEMBL proteins:

ENSP00000338283 ENSP00000397595 ENSP00000388528 ENSP00000395265 ENSP00000392125

ENSP00000393396 ENSP00000438428

Reactome Protein details: Q99743
Human Recombinant Protein Products for NPAS2:

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	Novus Biologicals NPAS2 Proteins Novus Biologicals NPAS2 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NPAS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005667	transcription factor complex	IPI	9576906
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

NPAS2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NPAS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NPAS2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001610 PAC

IPR013767 PAS_fold

IPR000014 PAS

IPR011598 HLH_dom

IPR001067 Nuc_translocat

Graphical View of Domain Structure for InterPro Entry Q99743

ProtoNet protein and cluster: Q99743

5 Blocks protein families:

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NPAS2_HUMAN, Q99743

Function: BMAL1-NPAS2 heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Genatlas biochemistry entry for NPAS2:

neuronal PAS domain protein 2,expressed in the central nervous system

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IPI	9576906
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0046983	protein dimerization activity	IEA	--
GO:0051879	Hsp90 protein binding	IDA	9079689

NPAS2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Npas2):

behavior/neurological

cardiovascular system

homeostasis/metabolism

nervous system

NPAS2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NPAS2

miRNA Products:		OriGene 3'-UTR Clone: NPAS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPAS2
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate NPAS2 (see all 58):
		hsa-miR-106a hsa-miR-374a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-508-3p hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: NPAS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NPAS2 (see all 7) OriGene shRNA RFP: NPAS2 OriGene siRNA: NPAS2
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NPAS2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPAS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer	1.00	Expression of NPAS2	0.33
Circadian Repression of Expression by REV-ERBA	0.75	Metabolic States and Circadian Oscillators	0.30
RORA Activates Circadian Expression	0.33

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Circadian rhythm - mammal

Circadian rhythm - mammal

1.00

Circadian Clock

0.41

Circadian rhythm pathway

Circadian rhythm pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NPAS2

Metabolic States and Circadian Oscillators

1 BioSystems Pathway for NPAS2

Circadian rhythm pathway

5/10 Reactome Pathways for NPAS2 (see all 10)

	Expression of NPAS2
	Circadian Clock
	Metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism
	Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer

1 Kegg Pathway (Kegg details for NPAS2):

Circadian rhythm - mammal

NPAS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NPAS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/48 Interacting proteins for NPAS2 (Q99743³ ENSP00000338283⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=2 STRING: ENSP00000262367
RARA	P10276³, ENSP00000254066⁴	I2D: score=2 STRING: ENSP00000254066
TRAF4	Q9BUZ4³, ENSP00000262395⁴	I2D: score=1 STRING: ENSP00000262395
ZSCAN1	Q8NBB4³, ENSP00000282326⁴	I2D: score=1 STRING: ENSP00000282326
ARNTL	O00327³, ENSP00000374357⁴	I2D: score=2 STRING: ENSP00000374357

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007417	central nervous system development	TAS	9012850
GO:0042745	circadian sleep/wake cycle	IEA	--
GO:0044255	cellular lipid metabolic process	TAS	--

NPAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPAS2
Search CenterWatch for drugs/clinical trials and news about NPAS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NPAS2 gene:

NM_002518.3

Unigene Clusters for NPAS2:

Neuronal PAS domain protein 2

Hs.156832 [show with all ESTs], Hs.705895 [show with all ESTs]

Unigene Representative Sequences: NM_002518, BC035412

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000335681(uc002tap.1 uc010yvt.1 uc010fit.1) ENST00000427413

ENST00000448812 ENST00000486017 ENST00000451740 ENST00000492373 ENST00000474550

ENST00000471974 ENST00000450763 ENST00000433408 ENST00000495559 ENST00000490052

ENST00000542504

miRNA Products:		OriGene 3'-UTR Clone: NPAS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NPAS2
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate NPAS2 (see all 58):
		hsa-miR-106a hsa-miR-374a hsa-miR-219-5p hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-508-3p hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: NPAS2 3' UTR sequence

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Additional cDNA sequence:

AK091665.1 BC035412.1

15 DOTS entries:

DT.436335 DT.100026680 DT.85102881 DT.95277739 DT.100786389 DT.40214010 DT.92431921 DT.121029483

DT.92431922 DT.121029652 DT.121029381 DT.65285512 DT.95221441 DT.95277736 DT.95277740

1 AceView cDNA sequence:

BC035412

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPAS2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18a	·	18b	·	18c	^	19	^
SP1:											-																-																		-
SP2:																																											-		-		-		-		-
SP3:
SP4:
SP5:

ExUns:	20	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:			-

ECgene alternative splicing isoforms for NPAS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NPAS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATACTGA

About this image

NPAS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NPAS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NPAS2

SOURCE GeneReport for Unigene clusters: Hs.156832 Hs.705895

SABiosciences Expression via Pathway-Focused PCR Array including NPAS2:

Circadian Rhythms in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NPAS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NPAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NPAS2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NPAS2¹	neuronal PAS domain protein 2	75.53(n) 74.78(a)		395433 NM_001030542.1 NP_001025713.1
lizard (Anolis carolinensis)	Reptilia	NPAS2⁶	--	63(a)	1 ↔ 1	GL343542.1(244589-290456)
zebrafish (Danio rerio)	Actinopterygii	AB087255.1²	--	74.59(n)		352934 AB087255.1
fruit fly (Drosophila melanogaster)	Insecta	Clk³	positive regulation of transcription, DNA-dependent more	50(a)		3 66A12 --

ENSEMBL Gene Tree for NPAS2 (if available)
TreeFam Gene Tree for NPAS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NPAS2 gene

ARNT2² CLOCK² ARNT² EPAS1² HIF1A² NPAS3² SIM2² SIM1²

HIF3A² ARNTL² ARNTL2² NPAS1²

8 SIMAP similar genes for NPAS2 using alignment to 10 protein entries: NPAS2_HUMAN (see all proteins):

clock CLOCK ARNTL2 ARNTL ARNT HIF3A

NCOA2 AHRR

NPAS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Polymorphism: Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a

depressive condition resulting from seasonal changes, and with diurnal preference

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77335327^1,2		--	95199646(+)	`GGGGAG/AGGAGA`	1	--	us2k¹		1		WA	118
rs115140840^1,2	C,F	--	95202024(+)	`CAAGCG/ACACAC`	1	--	int¹		1		WA	118
rs72968173^1,2	C	--	95203488(+)	`TGATTA/GATAGT`	1	--	int¹		2		WA	120
rs58427034^1,2		--	95203850(+)	`GGACAC/GCTGGG`	1	--	int¹		0	--	--	--	--
rs75289841^1,2		--	95203899(+)	`TGCACG/ACTGGC`	1	--	int¹		2		CSA WA	120
rs7587911^1,2	C	--	95204431(+)	`GAAGAA/GGTTAC`	1	--	int¹		0	--	--	--	--
rs72968178^1,2	C	--	95205615(+)	`AAAGAT/CAGAAA`	1	--	int¹		2		WA	120
rs72968180^1,2	C	--	95205783(+)	`AAATTC/TCCTTC`	1	--	int¹		2		WA	120
rs3914337^1,2	C,F	--	95205966(+)	`CATGCG/AGACCC`	1	--	int¹		3		WA CSA	122
rs10190559^1,2	C	--	95205997(+)	`gagggT/Cgggcc`	1	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for NPAS2 (101436613 - 101613291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NPAS2: --
Human Gene Mutation Database (HGMD): NPAS2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NPAS2 for disorders           About GeneDecksing

OMIM gene information: 603347    OMIM disorders: --

16 diseases for NPAS2:    About MalaCards

seasonal affective disorder neuronitis non-hodgkin lymphoma bipolar i disorder

chronic fatigue syndrome hodgkin's lymphoma autistic disorder schizoaffective disorder

mood disorder bipolar disorder prostate cancer breast cancer

hypoxia prostatitis schizophrenia alcoholism

Human Genome Epidemiology (HuGE) Navigator: NPAS2 (22 documents)

Export disorders for NPAS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NPAS2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with NPAS2)

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Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PubMed id 9012850)^{1, 2, 3} Zhou Y.-D.... McKnight S.L. (1997)
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)^{1, 2, 3} Hogenesch J.B.... Bradfield C.A. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. (PubMed id 12655319)^{1, 2} Johansson C.... Partonen T. (2003)
The circadian gene NPAS2 is a novel prognostic biomar ker for breast cancer. (PubMed id 19649706)^{1, 9} Yi C....Katsaro D. (2009)
The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. (PubMed id 18819933)^{1, 9} Hoffman A.E....Zhu Y. (2008)
Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. (PubMed id 17453337)^{1, 9} Zhu Y....Zheng T. (2008)
Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (PubMed id 17096334)^{1, 9} Zhu Y....Zheng T. (2007)
Genome-wide study links MTMR7 gene to variant Creutzfe ldt-Jakob risk. (PubMed id 22137330)¹ Sanchez-Juan P....van Duijn C.M. (2012)
Convergent genomic studies identify association of GR IK2 and NPAS2 with chronic fatigue syndrome. (PubMed id 21912186)¹ Smith A.K....Rajeevan M.S. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4862	HGNC: 7895	AceView: NPAS2.1	Ensembl:ENSG00000170485	euGenes: HUgn4862
ECgene: NPAS2	Kegg: 4862	H-InvDB: NPAS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NPAS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NPAS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NPAS2 gene:
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neuronal PAS domain protein 2

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NPAS2 Gene

neuronal PAS domain protein 2

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