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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NPAS2 Gene

protein-coding   GIFtS: 61
GCID: GC02P101436

Neuronal PAS Domain Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuronal PAS Domain Protein 21 2     PASD42 3
MOP42 3 5     bHLHe92 3
Basic-Helix-Loop-Helix-PAS Protein MOP42 3     PAS Domain-Containing Protein 42 3
Class E Basic Helix-Loop-Helix Protein 92 3     Member Of PAS Superfamily 42
Member Of PAS Protein 42 3     Neuronal PAS Domain-Containing Protein 22
Neuronal PAS22 3     BHLHE93

External Ids:    HGNC: 78951   Entrez Gene: 48622   Ensembl: ENSG000001704857   OMIM: 6033475   UniProtKB: Q997433   

Export aliases for NPAS2 gene to outside databases

Previous GC identifers: GC02P099300 GC02P099889 GC02P101041 GC02P101058 GC02P100895 GC02P100803 GC02P095284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPAS2 Gene:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription
factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It
also may function as a part of a molecular clock operative in the mammalian forebrain. (provided by RefSeq, Jul
2008)

GeneCards Summary for NPAS2 Gene: 
NPAS2 (neuronal PAS domain protein 2) is a protein-coding gene. Diseases associated with NPAS2 include seasonal affective disorder, and autistic disorder, and among its related super-pathways are Circadian Clock and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
Function: BMAL1-NPAS2 heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of
the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By
similarity)

Gene Wiki entry for NPAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPAS2 gene promoter:
         AML1a   C/EBPalpha   Evi-1   HNF-1A   CP2   HNF-1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNPAS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NPAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NPAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

NPAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAS2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P101436:  view genomic region     (about GC identifiers)

Start:
101,436,613 bp from pter      End:
101,613,291 bp from pter
Size:
176,679 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743 (See protein sequence)
Recommended Name: Neuronal PAS domain-containing protein 2  
Size: 824 amino acids; 91791 Da
Subunit: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or
BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with
another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4ZFV9 Q53SQ3 Q86V96 Q99629

Explore the universe of human proteins at neXtProt for NPAS2: NX_Q99743

Explore proteomics data for NPAS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99743

  • NPAS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NPAS2 Protein Expression
    REFSEQ proteins: NP_002509.2  
    ENSEMBL proteins: 
     ENSP00000338283   ENSP00000397595   ENSP00000388528   ENSP00000395265   ENSP00000392125  
     ENSP00000393396   ENSP00000438428  
    Reactome Protein details: Q99743
    Human Recombinant Protein Products for NPAS2: 
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    Cloud-Clone Corp. Proteins for NPAS2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IPI9576906
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    NPAS2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    5/6 InterPro protein domains (see all 6):
     IPR013655 PAS_fold_3
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q99743

    ProtoNet protein and cluster: Q99743

    5 Blocks protein domains:
    IPB000014 PAS domain
    IPB001067 Nuclear translocator signature
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013655 PAS fold-3


    UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    NPAS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPAS2_HUMAN, Q99743
    Function: BMAL1-NPAS2 heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of
    the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By
    similarity)

         Genatlas biochemistry entry for NPAS2:
    neuronal PAS domain protein 2,expressed in the central nervous system

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IPI9576906
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    NPAS2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Npas2):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    NPAS2 for phenotypes           About GeneDecksing

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    SwitchGear 3'UTR luciferase reporter plasmidNPAS2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NPAS2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4RORA Activates Circadian Expression
    RORA Activates Circadian Expression
    5Metabolic States and Circadian Oscillators
    Metabolic States and Circadian Oscillators

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NPAS2
        Metabolic States and Circadian Oscillators

    1 BioSystems Pathway for NPAS2
        Circadian rhythm pathway

    5/8        Reactome Pathways for NPAS2 (see all 8)
        Circadian Clock
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    PPARA Activates Gene Expression


    1         Kegg Pathway  (Kegg details for NPAS2):
        Circadian rhythm


    NPAS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for NPAS2 (Q997433 ENSP000003382834) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    RARAP102763, ENSP000002540664I2D: score=2 STRING: ENSP00000254066
    TRAF4Q9BUZ43, ENSP000002623954I2D: score=1 STRING: ENSP00000262395
    ZSCAN1Q8NBB43, ENSP000002823264I2D: score=1 STRING: ENSP00000282326
    ARNTLO003273, ENSP000003743574I2D: score=2 STRING: ENSP00000374357
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction ----
    GO:0007417central nervous system development TAS9012850
    GO:0042745circadian sleep/wake cycle IEA--

    NPAS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NPAS2 gene: 
    NM_002518.3  

    Unigene Clusters for NPAS2:

    Neuronal PAS domain protein 2
    Hs.156832  [show with all ESTs], Hs.705895  [show with all ESTs]
    Unigene Representative Sequences: NM_002518, BC035412
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335681(uc002tap.1 uc010yvt.1 uc010fit.1) ENST00000427413
    ENST00000486017 ENST00000448812 ENST00000451740 ENST00000492373 ENST00000474550
    ENST00000471974 ENST00000450763 ENST00000433408 ENST00000495559 ENST00000490052
    ENST00000542504
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    Additional mRNA sequence: 

    AK091665.1 BC035412.1 

    15 DOTS entries:

    DT.436335  DT.100026680  DT.85102881  DT.95277739  DT.100786389  DT.40214010  DT.92431921  DT.121029483 
    DT.92431922  DT.121029652  DT.121029381  DT.65285512  DT.95221441  DT.95277736  DT.95277740 

    1 AceView cDNA sequence:

    BC035412 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPAS2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^
    SP1:                                -                                               -                                                     -                     
    SP2:                                                                                                                                -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:        -         


    ECgene alternative splicing isoforms for NPAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NPAS2 expression in normal human tissues (normalized intensities)      NPAS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATACTGA
    NPAS2 Expression
    About this image


    NPAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Fetal Liver Stromal Cells   
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Uncategorized (Uncategorized)
             PureStem Progenitor W10

    See NPAS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NPAS2

    SOURCE GeneReport for Unigene clusters: Hs.156832 Hs.705895
        SABiosciences Expression via Pathway-Focused PCR Array including NPAS2: 
              Circadian Rhythms in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NPAS2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Npas21 , 5 neuronal PAS domain protein 21, 5 86.9(n)1
    88.55(a)1
      1 (17.98 cM)5
    181431  NM_008719.21  NP_032745.21 
     391937315 
    chicken
    (Gallus gallus)
    Aves NPAS21 neuronal PAS domain protein 2 75.53(n)
    74.78(a)
      395433  NM_001030542.1  NP_001025713.1 
    lizard
    (Anolis carolinensis)
    Reptilia NPAS26
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343542.1(244589-337732)
    zebrafish
    (Danio rerio)
    Actinopterygii AB087255.12   -- 74.59(n)   352934  AB087255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Clk3 positive regulation of transcription,
    DNA-dependent more
    50(a)   3 66A12   --


    ENSEMBL Gene Tree for NPAS2 (if available)
    TreeFam Gene Tree for NPAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NPAS2 gene
    ARNT22  CLOCK2  ARNT2  EPAS12  NPAS32  HIF1A2  SIM22  SIM12  
    HIF3A2  ARNTL2  NPAS12  ARNTL22  
    8 SIMAP similar genes for NPAS2 using alignment to 10 protein entries:     NPAS2_HUMAN (see all proteins):
    clock    CLOCK    ARNTL2    ARNTL    ARNT    HIF3A
    NCOA2    AHRR

    NPAS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
    Polymorphism: Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a
    depressive condition resulting from seasonal changes, and with diurnal preference


    10/3891 SNPs in NPAS2 are shown (see all 3891)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389481671,2
    C--95292420(+) TTATT-/A/    
       TATTA
    ATTAT
    1 -- int10--------
    rs342763811,2
    C--95295361(+) GAACC-/CT/TC 
            
    TCTCT
    1 -- int10--------
    rs345733291,2
    C,F--95304890(+) GGCCA-/CCCCGT 1 -- int13Minor allele frequency- C:0.33NA CSA 6
    rs67054661,2
    C,F,A,H--95333929(+) AAAAAA/CAAAAA 1 -- int13Minor allele frequency- C:0.40NA 10
    rs1388291941,2
    C--95333929(+) AAAAA-/CAAAAA 1 -- int10--------
    rs118903711,2
    C,H--95339639(+) AAAAAA/CACAAA 1 -- int1 trp30--------
    rs2017055351,2
    --95360009(+) ATAAC-/TATATAT 1 -- int10--------
    rs134326241,2
    C--95360029(+) TATATA/TTTTTT 1 -- int10--------
    rs75588581,2
    C--95360031(+) TATATA/TTTTTT 1 -- int1 trp30--------
    rs772122221,2
    C--95361517(+) GTCGTGAA/-GAAGC 1 -- cds11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for NPAS2 (101436613 - 101613291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NPAS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720445CNV Deletion23290073
    esv2667827CNV Deletion23128226
    nsv834315CNV Gain17160897
    nsv834316CNV Gain17160897
    nsv829584CNV Gain20364138


    Human Gene Mutation Database (HGMD): NPAS2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NPAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for NPAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603347    OMIM disorders: --

    16 diseases for NPAS2:    About MalaCards
    seasonal affective disorder    autistic disorder    neuronitis    bipolar i disorder
    chronic fatigue syndrome    schizoaffective disorder    mood disorder    bipolar disorder
    hodgkin's lymphoma    non-hodgkin lymphoma    alcoholism    schizophrenia
    hypoxia    prostate cancer    prostatitis    breast cancer


    NPAS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NPAS2
    Human Genome Epidemiology (HuGE) Navigator: NPAS2 (22 documents)

    Export disorders for NPAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NPAS2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with NPAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PubMed id 9012850)1, 2, 3 Zhou Y.-D.... McKnight S.L. (1997)
    2. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)1, 2, 3 Hogenesch J.B.... Bradfield C.A. (1997)
    3. The circadian gene NPAS2 is a novel prognostic biomar ker for breast cancer. (PubMed id 19649706)1, 4, 9 Yi C....Katsaro D. (2009)
    4. Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. (PubMed id 17453337)1, 4, 9 Zhu Y....Zheng T. (2008)
    5. Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (PubMed id 17096334)1, 4, 9 Zhu Y....Zheng T. (2007)
    6. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (2010)
    7. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (2010)
    8. PER2 variantion is associated with depression vulnera bility. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (2010)
    9. Circadian clock gene polymorphisms in alcohol use dis orders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (2010)
    10. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CL OCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4862 HGNC: 7895 AceView: NPAS2.1 Ensembl:ENSG00000170485 euGenes: HUgn4862
    ECgene: NPAS2 Kegg: 4862 H-InvDB: NPAS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NPAS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NPAS2 gene:
    Search GeneIP for patents involving NPAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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