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Aliases for NPAS1 Gene

Aliases for NPAS1 Gene

  • Neuronal PAS Domain Protein 1 2 3
  • Neuronal PAS1 2 3 4
  • MOP5 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 11 3 4
  • Basic-Helix-Loop-Helix-PAS Protein MOP5 3 4
  • PAS Domain-Containing Protein 5 3 4
  • Member Of PAS Superfamily 5 2 3
  • Member Of PAS Protein 5 3 4
  • BHLHe11 3 4
  • PASD5 3 4
  • Neuronal PAS Domain-Containing Protein 1 3

External Ids for NPAS1 Gene

Summaries for NPAS1 Gene

Entrez Gene Summary for NPAS1 Gene

  • The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPAS1 Gene

NPAS1 (Neuronal PAS Domain Protein 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for NPAS1 Gene

  • May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPAS1 Gene

Genomics for NPAS1 Gene

Genomic Location for NPAS1 Gene

47,019,820 bp from pter
47,045,775 bp from pter
25,956 bases
Plus strand

Genomic View for NPAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NPAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPAS1 Gene

Regulatory Elements for NPAS1 Gene

Proteins for NPAS1 Gene

  • Protein details for NPAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal PAS domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DR69
    • Q99632
    • Q9BY83

    Protein attributes for NPAS1 Gene

    590 amino acids
    Molecular mass:
    62702 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT (By similarity).

    Alternative splice isoforms for NPAS1 Gene


neXtProt entry for NPAS1 Gene

Proteomics data for NPAS1 Gene at MOPED

Post-translational modifications for NPAS1 Gene

No Post-translational modifications

Other Protein References for NPAS1 Gene

No data available for DME Specific Peptides for NPAS1 Gene

Domains for NPAS1 Gene

Gene Families for NPAS1 Gene

  • bHLH :Basic helix-loop-helix proteins


  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • Q99742
  • Contains 1 PAC (PAS-associated C-terminal) domain.:
    • Q99742
  • Contains 2 PAS (PER-ARNT-SIM) domains.:
    • Q99742
genes like me logo Genes that share domains with NPAS1: view

Function for NPAS1 Gene

Molecular function for NPAS1 Gene

GENATLAS Biochemistry: neuronal PAS domain protein 1,expressed in the central nervous system
UniProtKB/Swiss-Prot Function: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity).

Gene Ontology (GO) - Molecular Function for NPAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9012850
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NPAS1: view

Phenotypes for NPAS1 Gene

genes like me logo Genes that share phenotypes with NPAS1: view

miRNA for NPAS1 Gene

miRTarBase miRNAs that target NPAS1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NPAS1 Gene

Localization for NPAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPAS1 Gene

Subcellular locations from

Jensen Localization Image for NPAS1 Gene COMPARTMENTS Subcellular localization image for NPAS1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NPAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NPAS1: view

Pathways for NPAS1 Gene

SuperPathways for NPAS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001964 startle response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with NPAS1: view

No data available for Pathways by source for NPAS1 Gene

Transcripts for NPAS1 Gene

Unigene Clusters for NPAS1 Gene

Neuronal PAS domain protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPAS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: -
SP10: - - -

Relevant External Links for NPAS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPAS1 Gene

mRNA expression in normal human tissues for NPAS1 Gene

mRNA differential expression in normal tissues according to GTEx for NPAS1 Gene

This gene is overexpressed in Brain - Cortex (5.7), Brain - Hippocampus (4.9), Brain - Frontal Cortex (BA9) (4.6), and Brain - Anterior cingulate cortex (BA24) (4.3).

SOURCE GeneReport for Unigene cluster for NPAS1 Gene Hs.79564

genes like me logo Genes that share expressions with NPAS1: view

Orthologs for NPAS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPAS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NPAS1 36
  • 99.55 (n)
  • 99.83 (a)
NPAS1 37
  • 100 (a)
(Bos Taurus)
Mammalia NPAS1 36
  • 87.76 (n)
  • 89.54 (a)
NPAS1 37
  • 89 (a)
(Canis familiaris)
Mammalia NPAS1 36
  • 88.19 (n)
  • 90.17 (a)
NPAS1 37
  • 90 (a)
(Mus musculus)
Mammalia Npas1 36
  • 83.84 (n)
  • 86.78 (a)
Npas1 16
Npas1 37
  • 87 (a)
(Monodelphis domestica)
Mammalia NPAS1 37
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia NPAS1 37
  • 46 (a)
(Rattus norvegicus)
Mammalia Npas1 36
  • 82.54 (n)
  • 86.78 (a)
(Danio rerio)
Actinopterygii npas3b 36
  • 63.08 (n)
  • 62.1 (a)
npas3b 37
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta trh 37
  • 25 (a)
trh 38
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3066 37
  • 24 (a)
Species with no ortholog for NPAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPAS1 Gene

Gene Tree for NPAS1 (if available)
Gene Tree for NPAS1 (if available)

Paralogs for NPAS1 Gene

Paralogs for NPAS1 Gene

Selected SIMAP similar genes for NPAS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NPAS1: view

Variants for NPAS1 Gene

Sequence variations from dbSNP and Humsavar for NPAS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1050741 -- 47,045,224(+) GGCTG(C/T)CCCAG reference, missense, utr-variant-3-prime
rs1050742 -- 47,045,300(+) AAAGG(C/T)TCCGA reference, synonymous-codon, utr-variant-3-prime
rs1131303 -- 47,036,072(+) CCCCG(C/T)cctcc reference, missense
rs1363760 -- 47,041,359(+) GGAAG(G/T)CAGGG intron-variant
rs1477340 -- 47,026,483(+) GGTGG(C/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPAS1 Gene

Variant ID Type Subtype PubMed ID
nsv912192 CNV Loss 21882294
esv33386 CNV Gain 17666407
nsv912193 CNV Loss 21882294
esv2560518 CNV Deletion 19546169
dgv15e24 CNV Gain 17666407
esv2718657 CNV Deletion 23290073
dgv649e199 CNV Deletion 23128226
esv1670372 CNV Deletion 17803354
esv2718658 CNV Deletion 23290073
esv2718659 CNV Deletion 23290073
esv2718660 CNV Deletion 23290073
nsv2512 CNV Insertion 18451855
dgv3962n71 CNV Loss 21882294

Relevant External Links for NPAS1 Gene

HapMap Linkage Disequilibrium report

Disorders for NPAS1 Gene

No disorders were found for NPAS1 Gene.

No data available for UniProtKB/Swiss-Prot for NPAS1 Gene

Publications for NPAS1 Gene

  1. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PMID: 9012850) Zhou Y.-D. … McKnight S.L. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PMID: 9079689) Hogenesch J.B. … Bradfield C.A. (J. Biol. Chem. 1997) 2 3 4
  3. Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells. (PMID: 15635607) Ohsawa S. … Miura M. (J. Neurosci. Res. 2005) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for NPAS1 Gene

Sources for NPAS1 Gene

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