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NOXRED1 Gene

protein-coding   GIFtS: 33
GCID: GC14M077861

NADP-Dependent Oxidoreductase Domain Containing 1

(Previous name: chromosome 14 open reading frame 148)
(Previous symbol: C14orf148)
  Search for NOXRED1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADP-Dependent Oxidoreductase Domain Containing 11 2
C14orf1481 2 3
Pyrroline-5-Carboxylate Reductase-Like Protein C14orf1482 3
Chromosome 14 Open Reading Frame 1481
NADP-Dependent Oxidoreductase Domain-Containing Protein 12
EC 1.-.-.-3

External Ids:    HGNC: 204871   Entrez Gene: 1229452   Ensembl: ENSG000001655557   UniProtKB: Q6NXP63   

Export aliases for NOXRED1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOXRED1 Gene:
NOXRED1 (NADP-dependent oxidoreductase domain containing 1) is a protein-coding gene. GO annotations related to this gene include pyrroline-5-carboxylate reductase activity.

UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6
Function: Probable oxidoreductase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NOXRED1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOXRED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

NOXRED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOXRED1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077861:  view genomic region     (about GC identifiers)

Start:
77,860,364 bp from pter      End:
77,889,860 bp from pter
Size:
29,497 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6 (See protein sequence)
Recommended Name: NADP-dependent oxidoreductase domain-containing protein 1  
Size: 359 amino acids; 39880 Da
Secondary accessions: B3KQ47 O95435
Alternative splicing: 2 isoforms:  Q6NXP6-1   Q6NXP6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NOXRED1: NX_Q6NXP6

Explore proteomics data for NOXRED1 at MOPED


See NOXRED1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001106946.1  
ENSEMBL proteins: 
 ENSP00000370215   ENSP00000450597   ENSP00000298358  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000304 Pyrroline-COOH_reductase
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q6NXP6

ProtoNet protein and cluster: Q6NXP6

UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6
Similarity: Belongs to the pyrroline-5-carboxylate reductase family


NOXRED1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NXRD1_HUMAN, Q6NXP6
Function: Probable oxidoreductase (By similarity)

     Enzyme Number (IUBMB): EC 1.-.-.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0004735pyrroline-5-carboxylate reductase activity IEA--
     
NOXRED1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for NOXRED1:
 Decreased viability with pacli 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

NOXRED1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOXRED1
Interactions:

    Search GeneGlobe Interaction Network for NOXRED1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NOXRED1 (ENSP000003702154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RPS6ENSP000003697574STRING: ENSP00000369757
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006561proline biosynthetic process IEA--
GO:0008150biological_process ND--

NOXRED1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NOXRED1 (NXRD1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NOXRED1 gene (2 alternative transcripts): 
NM_138791.1  NM_001113475.2  

Unigene Cluster for NOXRED1:

NADP-dependent oxidoreductase domain containing 1
Hs.97556  [show with all ESTs]
Unigene Representative Sequence: NM_001113475
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380835(uc001xtr.3) ENST00000555901(uc010tvi.2) ENST00000555603
ENST00000298358
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Additional mRNA sequence: BC066965.1 

3 DOTS entries:

DT.405238  DT.91810520  DT.91740673 

16 AceView cDNA sequences:

BX279687 NM_138791 AI638525 AA399545 BE466033 AK057371 BF980278 BI829015 
AW594240 AA397580 AI824915 BC066965 AI138314 AA868184 BF979635 BE463834 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NOXRED1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTATTTTGA
NOXRED1 Expression
About this image

NOXRED1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NOXRED1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.97556
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NOXRED1 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Noxred11 , 5 RIKEN cDNA 4933437F05 gene5
NADP+ dependent oxidoreductase domain containing 11
73.11(n)1
63.35(a)1
  12 (41.42 cM)5
712751  NM_027744.11  NP_082020.11 
 872212555 
chicken
(Gallus gallus)
Aves NOXRED11 NADP-dependent oxidoreductase domain containing 1 59.25(n)
50.18(a)
  772029  XM_001235230.3  XP_001235231.2 
lizard
(Anolis carolinensis)
Reptilia NOXRED16
NADP-dependent oxidoreductase domain containing 1
42(a)
1 ↔ 1
1(20719723-20727315)
tropical clawed frog
(Xenopus tropicalis)
Amphibia noxred11 NADP-dependent oxidoreductase domain containing 1 51.72(n)
46.67(a)
  780191  NM_001079266.1  NP_001072734.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1018849341 NADP-dependent oxidoreductase domain-containing protein more 50.46(n)
41.49(a)
  101884934  XM_005169872.1  XP_005169929.1 


ENSEMBL Gene Tree for NOXRED1 (if available)
TreeFam Gene Tree for NOXRED1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NOXRED1 (see all 659)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1821316211,2
--77859878(+) TTTACA/CGATTT 1 -- int10--------
rs1411204391,2
C--77860008(+) GTTTT-/TCTGTTT 1 -- int10--------
rs1889172491,2
--77860087(+) CCTAAC/TATTTT 1 -- int10--------
rs1414826931,2
--77860102(+) AATTGA/GACTAA 1 -- int10--------
rs1932431171,2
--77860273(+) AGTTAC/TGTTCT 1 -- int10--------
rs1853503671,2
--77860359(+) AATCAA/GCAAAT 1 -- int10--------
rs783844851,2
C,F--77860502(+) CAAGCC/TATAAT 1 -- ut311Minor allele frequency- T:0.13WA 118
rs1165995551,2
C,F--77860503(+) AAGCCA/GTAATT 1 -- ut311Minor allele frequency- G:0.02WA 118
rs45754691,2
C,F,A,H--77860543(+) TCTCTA/GTCCAA 1 -- ut31 ese332Minor allele frequency- N:0.00EA NA NS WA CSA 2986
rs1900558751,2
--77860620(+) ATTTAA/TTGGAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for NOXRED1 (77860364 - 77889860 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NOXRED1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NOXRED1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NOXRED1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NOXRED1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 122945 HGNC: 20487 AceView: C14orf148 Ensembl:ENSG00000165555 euGenes: HUgn122945
ECgene: NOXRED1 H-InvDB: NOXRED1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NOXRED1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NOXRED1 gene:
Search GeneIP for patents involving NOXRED1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOXRED1
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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