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Aliases for NOXRED1 Gene

Aliases for NOXRED1 Gene

  • NADP-Dependent Oxidoreductase Domain Containing 1 2 3
  • Pyrroline-5-Carboxylate Reductase-Like Protein C14orf148 3 4
  • C14orf148 3 4
  • NADP-Dependent Oxidoreductase Domain-Containing Protein 1 3
  • Chromosome 14 Open Reading Frame 148 2
  • EC 1.-.-.- 4

External Ids for NOXRED1 Gene

Previous HGNC Symbols for NOXRED1 Gene

  • C14orf148

Previous GeneCards Identifiers for NOXRED1 Gene

  • GC14M077861

Summaries for NOXRED1 Gene

GeneCards Summary for NOXRED1 Gene

NOXRED1 (NADP-Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include pyrroline-5-carboxylate reductase activity.

UniProtKB/Swiss-Prot for NOXRED1 Gene

  • Probable oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXRED1 Gene

Genomics for NOXRED1 Gene

Genomic Location for NOXRED1 Gene

Start:
77,393,484 bp from pter
End:
77,423,882 bp from pter
Size:
30,399 bases
Orientation:
Minus strand

Genomic View for NOXRED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOXRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXRED1 Gene

No data available for Regulatory Elements for NOXRED1 Gene

Proteins for NOXRED1 Gene

  • Protein details for NOXRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXP6-NXRD1_HUMAN
    Recommended name:
    NADP-dependent oxidoreductase domain-containing protein 1
    Protein Accession:
    Q6NXP6
    Secondary Accessions:
    • B3KQ47
    • O95435

    Protein attributes for NOXRED1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOXRED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXRED1 Gene

Proteomics data for NOXRED1 Gene at MOPED

Post-translational modifications for NOXRED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXRED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOXRED1 Gene

Domains for NOXRED1 Gene

Protein Domains for NOXRED1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NXP6

UniProtKB/Swiss-Prot:

NXRD1_HUMAN :
  • Q6NXP6
Family:
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with NOXRED1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NOXRED1 Gene

Function for NOXRED1 Gene

Molecular function for NOXRED1 Gene

UniProtKB/Swiss-Prot Function: Probable oxidoreductase.

Enzyme Numbers (IUBMB) for NOXRED1 Gene

Gene Ontology (GO) - Molecular Function for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004735 pyrroline-5-carboxylate reductase activity IEA --
genes like me logo Genes that share ontologies with NOXRED1: view

Phenotypes for NOXRED1 Gene

GenomeRNAi human phenotypes for NOXRED1:
genes like me logo Genes that share phenotypes with NOXRED1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOXRED1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NOXRED1 Gene

Localization for NOXRED1 Gene

Gene Ontology (GO) - Cellular Components for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NOXRED1 Gene

Pathways for NOXRED1 Gene

SuperPathways for NOXRED1 Gene

No Data Available

Interacting Proteins for NOXRED1 Gene

Gene Ontology (GO) - Biological Process for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006561 proline biosynthetic process IEA --
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Pathways by source for NOXRED1 Gene

Transcripts for NOXRED1 Gene

mRNA/cDNA for NOXRED1 Gene

(16) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(7) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOXRED1 Gene

NADP-dependent oxidoreductase domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOXRED1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NOXRED1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOXRED1 Gene

No ASD Table

Relevant External Links for NOXRED1 Gene

GeneLoc Exon Structure for
NOXRED1
ECgene alternative splicing isoforms for
NOXRED1

Expression for NOXRED1 Gene

mRNA expression in normal human tissues for NOXRED1 Gene

mRNA differential expression in normal tissues according to GTEx for NOXRED1 Gene

This gene is overexpressed in Testis (12.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NOXRED1 Gene

SOURCE GeneReport for Unigene cluster for NOXRED1 Gene Hs.97556

genes like me logo Genes that share expressions with NOXRED1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NOXRED1 Gene

Orthologs for NOXRED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXRED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOXRED1 35
  • 99.26 (n)
  • 98.89 (a)
NOXRED1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOXRED1 35
  • 77.37 (n)
  • 70.67 (a)
NOXRED1 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOXRED1 35
  • 82.4 (n)
  • 74.02 (a)
NOXRED1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noxred1 35
  • 73.11 (n)
  • 63.35 (a)
Noxred1 16
Noxred1 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOXRED1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOXRED1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noxred1 35
  • 72.98 (n)
  • 59.32 (a)
chicken
(Gallus gallus)
Aves NOXRED1 35
  • 59.25 (n)
  • 50.18 (a)
NOXRED1 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOXRED1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noxred1 35
  • 51.72 (n)
  • 46.67 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884934 35
  • 50.46 (n)
  • 41.49 (a)
NOXRED1 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for NOXRED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXRED1 Gene

ENSEMBL:
Gene Tree for NOXRED1 (if available)
TreeFam:
Gene Tree for NOXRED1 (if available)

Paralogs for NOXRED1 Gene

No data available for Paralogs for NOXRED1 Gene

Variants for NOXRED1 Gene

Sequence variations from dbSNP and Humsavar for NOXRED1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs147316 -- 77,422,321(-) TACCC(A/G)GGACT intron-variant
rs176766 -- 77,399,024(+) atcat(A/G)tctga intron-variant
rs176767 -- 77,399,271(+) aacaa(A/G)gtgag intron-variant
rs176768 -- 77,402,974(+) agatc(A/G)cagtg intron-variant
rs176769 -- 77,404,339(+) aatac(A/G)aaaga intron-variant

Relevant External Links for NOXRED1 Gene

HapMap Linkage Disequilibrium report
NOXRED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOXRED1 Gene

Disorders for NOXRED1 Gene

No disorders were found for NOXRED1 Gene.

No data available for UniProtKB/Swiss-Prot for NOXRED1 Gene

Publications for NOXRED1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NOXRED1 Gene

Sources for NOXRED1 Gene

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