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Aliases for NOXRED1 Gene

Aliases for NOXRED1 Gene

  • NADP-Dependent Oxidoreductase Domain Containing 1 2 3 5
  • Pyrroline-5-Carboxylate Reductase-Like Protein C14orf148 3 4
  • C14orf148 3 4
  • Chromosome 14 Open Reading Frame 148 2
  • EC 1.-.-.- 4

External Ids for NOXRED1 Gene

Previous HGNC Symbols for NOXRED1 Gene

  • C14orf148

Previous GeneCards Identifiers for NOXRED1 Gene

  • GC14M077861

Summaries for NOXRED1 Gene

GeneCards Summary for NOXRED1 Gene

NOXRED1 (NADP-Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include pyrroline-5-carboxylate reductase activity.

UniProtKB/Swiss-Prot for NOXRED1 Gene

  • Probable oxidoreductase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXRED1 Gene

Genomics for NOXRED1 Gene

Regulatory Elements for NOXRED1 Gene

Enhancers for NOXRED1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOXRED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOXRED1 Gene

77,394,021 bp from pter
77,426,011 bp from pter
31,991 bases
Minus strand

Genomic View for NOXRED1 Gene

Genes around NOXRED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXRED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXRED1 Gene

Proteins for NOXRED1 Gene

  • Protein details for NOXRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADP-dependent oxidoreductase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KQ47
    • O95435

    Protein attributes for NOXRED1 Gene

    359 amino acids
    Molecular mass:
    39880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOXRED1 Gene


neXtProt entry for NOXRED1 Gene

Proteomics data for NOXRED1 Gene at MOPED

Post-translational modifications for NOXRED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXRED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOXRED1 Gene

Domains & Families for NOXRED1 Gene

Protein Domains for NOXRED1 Gene

Suggested Antigen Peptide Sequences for NOXRED1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pyrroline-5-carboxylate reductase family.
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with NOXRED1: view

No data available for Gene Families for NOXRED1 Gene

Function for NOXRED1 Gene

Molecular function for NOXRED1 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for NOXRED1 Gene

genes like me logo Genes that share phenotypes with NOXRED1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NOXRED1 Gene

Localization for NOXRED1 Gene

Subcellular locations from

Jensen Localization Image for NOXRED1 Gene COMPARTMENTS Subcellular localization image for NOXRED1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NOXRED1 Gene

Pathways & Interactions for NOXRED1 Gene

SuperPathways for NOXRED1 Gene

No Data Available

Interacting Proteins for NOXRED1 Gene

Gene Ontology (GO) - Biological Process for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006561 proline biosynthetic process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Pathways by source and SIGNOR curated interactions for NOXRED1 Gene

Drugs & Compounds for NOXRED1 Gene

No Compound Related Data Available

Transcripts for NOXRED1 Gene

mRNA/cDNA for NOXRED1 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOXRED1 Gene

NADP-dependent oxidoreductase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOXRED1 Gene

No ASD Table

Relevant External Links for NOXRED1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOXRED1 Gene

mRNA expression in normal human tissues for NOXRED1 Gene

mRNA differential expression in normal tissues according to GTEx for NOXRED1 Gene

This gene is overexpressed in Testis (x12.1).

Protein differential expression in normal tissues from HIPED for NOXRED1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOXRED1 Gene

SOURCE GeneReport for Unigene cluster for NOXRED1 Gene Hs.97556

genes like me logo Genes that share expression patterns with NOXRED1: view

Protein tissue co-expression partners for NOXRED1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NOXRED1 Gene

Orthologs for NOXRED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXRED1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOXRED1 35
  • 77.37 (n)
  • 70.67 (a)
  • 69 (a)
(Canis familiaris)
Mammalia NOXRED1 35
  • 82.4 (n)
  • 74.02 (a)
  • 64 (a)
(Mus musculus)
Mammalia Noxred1 35
  • 73.11 (n)
  • 63.35 (a)
Noxred1 16
Noxred1 36
  • 60 (a)
(Pan troglodytes)
Mammalia NOXRED1 35
  • 99.26 (n)
  • 98.89 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Noxred1 35
  • 72.98 (n)
  • 59.32 (a)
(Monodelphis domestica)
Mammalia NOXRED1 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia NOXRED1 36
  • 54 (a)
(Gallus gallus)
Aves NOXRED1 35
  • 59.25 (n)
  • 50.18 (a)
  • 41 (a)
(Anolis carolinensis)
Reptilia NOXRED1 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia noxred1 35
  • 51.72 (n)
  • 46.67 (a)
(Danio rerio)
Actinopterygii LOC101884934 35
  • 50.46 (n)
  • 41.49 (a)
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for NOXRED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXRED1 Gene

Gene Tree for NOXRED1 (if available)
Gene Tree for NOXRED1 (if available)

Paralogs for NOXRED1 Gene

No data available for Paralogs for NOXRED1 Gene

Variants for NOXRED1 Gene

Sequence variations from dbSNP and Humsavar for NOXRED1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs147316 -- 77,422,321(-) TACCC(A/G)GGACT intron-variant
rs176766 -- 77,399,024(+) atcat(A/G)tctga intron-variant
rs176767 -- 77,399,271(+) aacaa(A/G)gtgag intron-variant
rs176768 -- 77,402,974(+) agatc(A/G)cagtg intron-variant
rs176769 -- 77,404,339(+) aatac(A/G)aaaga intron-variant

Variation tolerance for NOXRED1 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NOXRED1 Gene

Disorders for NOXRED1 Gene

Relevant External Links for NOXRED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOXRED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOXRED1 Gene

Publications for NOXRED1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NOXRED1 Gene

Sources for NOXRED1 Gene