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Aliases for NOXRED1 Gene

Aliases for NOXRED1 Gene

  • NADP Dependent Oxidoreductase Domain Containing 1 2 3 5
  • Pyrroline-5-Carboxylate Reductase-Like Protein C14orf148 3 4
  • C14orf148 3 4
  • NADP-Dependent Oxidoreductase Domain-Containing Protein 1 3
  • Chromosome 14 Open Reading Frame 148 2
  • EC 1.-.-.- 4

External Ids for NOXRED1 Gene

Previous HGNC Symbols for NOXRED1 Gene

  • C14orf148

Previous GeneCards Identifiers for NOXRED1 Gene

  • GC14M077861

Summaries for NOXRED1 Gene

GeneCards Summary for NOXRED1 Gene

NOXRED1 (NADP Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include pyrroline-5-carboxylate reductase activity.

UniProtKB/Swiss-Prot for NOXRED1 Gene

  • Probable oxidoreductase.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXRED1 Gene

Genomics for NOXRED1 Gene

Regulatory Elements for NOXRED1 Gene

Enhancers for NOXRED1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G077561 0.8 ENCODE dbSUPER 4.6 -137.1 -137068 2.4 CTCF POLR2A BHLHE40 FOS RAD21 ZIC2 EZH2 GSTZ1 POMT2 SPTLC2 NOXRED1 RN7SL587P
GH14G077558 0.2 dbSUPER 4.6 -133.6 -133639 1.9 SPTLC2 NOXRED1 RN7SL587P
GH14G077406 1 Ensembl ENCODE 0.4 +18.7 18711 1.4 HDAC1 CTCF LEF1 TAL1 CEBPG TCF12 ZFHX2 ZNF766 GATA3 NCOR1 SAMD15 TMED8 AHSA1 VIPAS39 POMT2 GSTZ1 GC14M077403 NOXRED1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOXRED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOXRED1 Gene

Chromosome:
14
Start:
77,394,021 bp from pter
End:
77,426,011 bp from pter
Size:
31,991 bases
Orientation:
Minus strand

Genomic View for NOXRED1 Gene

Genes around NOXRED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXRED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXRED1 Gene

Proteins for NOXRED1 Gene

  • Protein details for NOXRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXP6-NXRD1_HUMAN
    Recommended name:
    NADP-dependent oxidoreductase domain-containing protein 1
    Protein Accession:
    Q6NXP6
    Secondary Accessions:
    • B3KQ47
    • O95435

    Protein attributes for NOXRED1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOXRED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXRED1 Gene

Post-translational modifications for NOXRED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXRED1 Gene

No data available for DME Specific Peptides for NOXRED1 Gene

Domains & Families for NOXRED1 Gene

Protein Domains for NOXRED1 Gene

Suggested Antigen Peptide Sequences for NOXRED1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NXP6

UniProtKB/Swiss-Prot:

NXRD1_HUMAN :
  • Belongs to the pyrroline-5-carboxylate reductase family.
Family:
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with NOXRED1: view

No data available for Gene Families for NOXRED1 Gene

Function for NOXRED1 Gene

Molecular function for NOXRED1 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for NOXRED1 Gene

Gene Ontology (GO) - Molecular Function for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004735 pyrroline-5-carboxylate reductase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with NOXRED1: view
genes like me logo Genes that share phenotypes with NOXRED1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NOXRED1 Gene

Localization for NOXRED1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOXRED1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NOXRED1 Gene

Pathways & Interactions for NOXRED1 Gene

SuperPathways for NOXRED1 Gene

No Data Available

Interacting Proteins for NOXRED1 Gene

Gene Ontology (GO) - Biological Process for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006561 proline biosynthetic process IEA --
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Pathways by source and SIGNOR curated interactions for NOXRED1 Gene

Drugs & Compounds for NOXRED1 Gene

No Compound Related Data Available

Transcripts for NOXRED1 Gene

mRNA/cDNA for NOXRED1 Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOXRED1 Gene

NADP-dependent oxidoreductase domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOXRED1 Gene

No ASD Table

Relevant External Links for NOXRED1 Gene

GeneLoc Exon Structure for
NOXRED1
ECgene alternative splicing isoforms for
NOXRED1

Expression for NOXRED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOXRED1 Gene

mRNA differential expression in normal tissues according to GTEx for NOXRED1 Gene

This gene is overexpressed in Testis (x12.1).

Protein differential expression in normal tissues from HIPED for NOXRED1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOXRED1 Gene



Protein tissue co-expression partners for NOXRED1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOXRED1 Gene:

NOXRED1

SOURCE GeneReport for Unigene cluster for NOXRED1 Gene:

Hs.97556
genes like me logo Genes that share expression patterns with NOXRED1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOXRED1 Gene

Orthologs for NOXRED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXRED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOXRED1 34 35
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia NOXRED1 34 35
  • 82.4 (n)
cow
(Bos Taurus)
Mammalia NOXRED1 34 35
  • 77.37 (n)
mouse
(Mus musculus)
Mammalia Noxred1 34 16 35
  • 73.11 (n)
rat
(Rattus norvegicus)
Mammalia Noxred1 34
  • 72.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOXRED1 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOXRED1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOXRED1 34 35
  • 59.25 (n)
lizard
(Anolis carolinensis)
Reptilia NOXRED1 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noxred1 34
  • 51.72 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884934 34
  • 50.46 (n)
NOXRED1 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for NOXRED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXRED1 Gene

ENSEMBL:
Gene Tree for NOXRED1 (if available)
TreeFam:
Gene Tree for NOXRED1 (if available)

Paralogs for NOXRED1 Gene

No data available for Paralogs for NOXRED1 Gene

Variants for NOXRED1 Gene

Sequence variations from dbSNP and Humsavar for NOXRED1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000003882 -- 77,424,840(+) TGCAA(C/G)ATCAG intron-variant, upstream-variant-2KB
rs1000067040 -- 77,401,625(+) TGCTT(A/G)AGCCC intron-variant
rs1000086100 -- 77,417,214(+) CCTAA(A/C)GTGAT intron-variant
rs1000333577 -- 77,401,273(+) AGGCT(C/G)AGGCA intron-variant
rs1000493967 -- 77,398,636(+) GACTA(C/T)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOXRED1 Gene

Variant ID Type Subtype PubMed ID
nsv1041985 CNV loss 25217958
nsv1362 CNV deletion 18451855
nsv85801 CNV deletion 16902084

Variation tolerance for NOXRED1 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOXRED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOXRED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOXRED1 Gene

Disorders for NOXRED1 Gene

Relevant External Links for NOXRED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOXRED1

No disorders were found for NOXRED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOXRED1 Gene

Publications for NOXRED1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for NOXRED1 Gene

Sources for NOXRED1 Gene

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