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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOXRED1 Gene

protein-coding   GIFtS: 36
GCID: GC14M077861

NADP-dependent oxidoreductase domain containing 1

(Previous name: chromosome 14 open reading frame 148 )
(Previous symbol: C14orf148)
  Search for NOXRED1
in
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Biological research products
for NOXRED1    

Aliases
for NOXRED1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NADP-Dependent Oxidoreductase Domain Containing 11 2     Chromosome 14 Open Reading Frame 1481
C14orf1481 2 3     NADP-Dependent Oxidoreductase Domain-Containing Protein 12
Pyrroline-5-Carboxylate Reductase-Like Protein C14orf1482 3     EC 1.-.-.-3
FLJ328091     

External Ids:    HGNC: 204871   Entrez Gene: 1229452   Ensembl: ENSG000001655557   UniProtKB: Q6NXP63   

Export aliases for NOXRED1 gene to outside databases


Summaries
for NOXRED1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6
Function: Probable oxidoreductase (By similarity)




Genomic Views
for NOXRED1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NOXRED1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NOXRED1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOXRED1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

NOXRED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOXRED1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077861:  view genomic region     (about GC identifiers)

Start:
 77,860,364 bp from pter      End:
 77,889,860 bp from pter
Size:
 29,497 bases      Orientation:
 minus strand

Proteins
for NOXRED1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6 (See protein sequence)
Recommended Name: NADP-dependent oxidoreductase domain-containing protein 1  
Size: 359 amino acids; 39880 Da
Secondary accessions: B3KQ47 O95435
Alternative splicing: 2 isoforms:  Q6NXP6-1   Q6NXP6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NOXRED1: NX_Q6NXP6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NXP6

    • NOXRED1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001106946.1  
    ENSEMBL proteins: 
     ENSP00000370215   ENSP00000450597   ENSP00000298358  

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    Uscn Proteins for NOXRED1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    NOXRED1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NOXRED1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOXRED1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004455 NADP_OxRdtase_F420
     IPR000304 Pyrroline-COOH_reductase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q6NXP6

    ProtoNet protein and cluster: Q6NXP6

    UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6
    Similarity: Belongs to the pyrroline-5-carboxylate reductase family


    Function
    for NOXRED1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NXRD1_HUMAN, Q6NXP6
    Function: Probable oxidoreductase (By similarity)

    Enzyme Number (IUBMB): EC 1.-.-.-1

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003674molecular_function ND--
    GO:0004735pyrroline-5-carboxylate reductase activity IEA--


    NOXRED1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NOXRED1:
     Decreased viability with pacli 


    Pathways & Interactions
    for NOXRED1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOXRED1

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006561proline biosynthetic process IEA--
    GO:0008150biological_process ND--


    NOXRED1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOXRED1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Transcripts
    for NOXRED1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for NOXRED1 gene (2 alternative transcripts): 
    NM_138791.1  NM_001113475.2  

    Unigene Cluster for NOXRED1:

    NADP-dependent oxidoreductase domain containing 1
    Hs.97556  [show with all ESTs]
    Unigene Representative Sequence: NM_001113475
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380835(uc001xtr.3) ENST00000555901(uc010tvi.2) ENST00000555603
    ENST00000298358

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    Inhib. RNA
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    Additional cDNA sequence: BC066965.1 

    3 DOTS entries:

    DT.405238  DT.91810520  DT.91740673 

    16 AceView cDNA sequences:

    BX279687 BE466033 AA399545 NM_138791 AI638525 AK057371 BC066965 AA397580 
    AI824915 BI829015 AW594240 AI138314 BF980278 AA868184 BF979635 BE463834 

    GeneLoc Exon Structure


    Expression
    for NOXRED1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOXRED1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTATTTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NOXRED1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOXRED1

    SOURCE GeneReport for Unigene cluster: Hs.97556
        SABiosciences Custom PCR Arrays for NOXRED1
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    In Situ
    Assay Products:     
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    Orthologs
    for NOXRED1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NOXRED1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Noxred11 , 5 RIKEN cDNA 4933437F05 gene5
    NADP+ dependent oxidoreductase domain containing 11    		 73.11(n)1
    63.35(a)1    		   12 (41.42 cM)5
    712751  NM_027744.11  NP_082020.11 
     872212555 
    chicken
    (Gallus gallus)    		 Aves NOXRED11 NADP-dependent oxidoreductase domain containing 1 59.25(n)
    50.18(a)    		   772029  XM_001235230.2  XP_001235231.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NOXRED16
    		 --
    		 42(a)
    		 1 ↔ 1
    		 1(20719723-20727315)
    zebrafish
    (Danio rerio)    		 Actinopterygii CU695222.16
    		 --
    		 38(a)
    		 1 ↔ 1
    		 17(45321802-45331093)


    ENSEMBL Gene Tree for NOXRED1 (if available)
    TreeFam Gene Tree for NOXRED1 (if available) 

    Paralogs
    for NOXRED1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NOXRED1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/546 NCBI SNPs in NOXRED1 are shown (see all 546)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1821316211,2
    		--77859878(+) TTTACA/CGATTT 1 -- int10--------
    rs1411204391,2
    		C,--77860008(+) GTTTT-/TCTGTTT 1 -- int10--------
    rs1889172491,2
    		--77860087(+) CCTAAC/TATTTT 1 -- int10--------
    rs1414826931,2
    		--77860102(+) AATTGA/GACTAA 1 -- int10--------
    rs1932431171,2
    		--77860273(+) AGTTAC/TGTTCT 1 -- int10--------
    rs1853503671,2
    		--77860359(+) AATCAA/GCAAAT 1 -- int10--------
    rs783844851,2
    		F,--77860502(+) CAAGCC/TATAAT 1 -- ut311Minor allele frequency- T:0.13WA 118
    rs1165995551,2
    		F,--77860503(+) AAGCCA/GTAATT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs45754691,2
    		C,F,A,H,--77860543(+) TCTCTA/GTCCAA 1 -- ut31 ese332Minor allele frequency- N:0.00EA NA NS WA CSA 2986
    rs1900558751,2
    		--77860620(+) ATTTAA/TTGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NOXRED1 (77860364 - 77889860 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NOXRED1: --

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    Disorders / Diseases
    for NOXRED1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for NOXRED1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOXRED1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NOXRED1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NOXRED1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOXRED1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 122945 HGNC: 20487 AceView: C14orf148 Ensembl:ENSG00000165555 euGenes: HUgn122945
    ECgene: NOXRED1 H-InvDB: NOXRED1

    Other Databases showing NOXRED1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOXRED1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOXRED1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NOXRED1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOXRED1 gene:
    Search GeneIP for patents involving NOXRED1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NOXRED1 gene

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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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