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Aliases for NOXO1 Gene

Aliases for NOXO1 Gene

  • NADPH Oxidase Organizer 1 2 3 5
  • SH3 And PX Domain-Containing Protein 5 3 4
  • NADPH Oxidase Regulatory Protein 3 4
  • Nox-Organizing Protein 1 3 4
  • Nox Organizer 1 3 4
  • SH3PXD5 3 4
  • P41NOX 3 4
  • Regulatory Protein P41NOX 3
  • P41NOXA 3
  • P41NOXB 3
  • P41NOXC 3
  • SNX28 3

External Ids for NOXO1 Gene

Previous GeneCards Identifiers for NOXO1 Gene

  • GC16M002055
  • GC16M001968
  • GC16M002028
  • GC16M001979
  • GC16M001980
  • GC16M001996

Summaries for NOXO1 Gene

Entrez Gene Summary for NOXO1 Gene

  • This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for NOXO1 Gene

NOXO1 (NADPH Oxidase Organizer 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include identical protein binding and phospholipid binding. An important paralog of this gene is NCF1.

UniProtKB/Swiss-Prot for NOXO1 Gene

  • Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

Gene Wiki entry for NOXO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXO1 Gene

Genomics for NOXO1 Gene

Regulatory Elements for NOXO1 Gene

Enhancers for NOXO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOXO1 on UCSC Golden Path with GeneCards custom track

Promoters for NOXO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOXO1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NOXO1 gene promoter:

Genomic Location for NOXO1 Gene

Chromosome:
16
Start:
1,978,917 bp from pter
End:
1,984,192 bp from pter
Size:
5,276 bases
Orientation:
Minus strand

Genomic View for NOXO1 Gene

Genes around NOXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXO1 Gene

Proteins for NOXO1 Gene

  • Protein details for NOXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFA2-NOXO1_HUMAN
    Recommended name:
    NADPH oxidase organizer 1
    Protein Accession:
    Q8NFA2
    Secondary Accessions:
    • Q86YM1
    • Q8NFA3
    • Q96B73

    Protein attributes for NOXO1 Gene

    Size:
    376 amino acids
    Molecular mass:
    41253 Da
    Quaternary structure:
    • Interacts with NOX1, NOXA1, CYBA/p22phox and NCF2/p67phox. Interacts with SH3PXD2A and SH3PXD2B.

    Three dimensional structures from OCA and Proteopedia for NOXO1 Gene

    Alternative splice isoforms for NOXO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXO1 Gene

Post-translational modifications for NOXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXO1 Gene

No data available for DME Specific Peptides for NOXO1 Gene

Domains & Families for NOXO1 Gene

Protein Domains for NOXO1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOXO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFA2

UniProtKB/Swiss-Prot:

NOXO1_HUMAN :
  • The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
Domain:
  • The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation.
  • The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region.
  • Contains 1 PX (phox homology) domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with NOXO1: view

No data available for Gene Families for NOXO1 Gene

Function for NOXO1 Gene

Molecular function for NOXO1 Gene

UniProtKB/Swiss-Prot Function:
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

Gene Ontology (GO) - Molecular Function for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16460309
GO:0005543 phospholipid binding TAS 16636067
GO:0016176 superoxide-generating NADPH oxidase activator activity TAS 16636067
GO:0019899 enzyme binding IPI 16636067
GO:0035091 phosphatidylinositol binding IEA,IBA --
genes like me logo Genes that share ontologies with NOXO1: view
genes like me logo Genes that share phenotypes with NOXO1: view

Animal Model Products

CRISPR Products

miRNA for NOXO1 Gene

miRTarBase miRNAs that target NOXO1

Clone Products

  • Addgene plasmids for NOXO1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOXO1 Gene

Localization for NOXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOXO1 Gene

Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOXO1 Gene COMPARTMENTS Subcellular localization image for NOXO1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
peroxisome 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0043020 NADPH oxidase complex IDA 16636067
genes like me logo Genes that share ontologies with NOXO1: view

Pathways & Interactions for NOXO1 Gene

genes like me logo Genes that share pathways with NOXO1: view

Pathways by source for NOXO1 Gene

SIGNOR curated interactions for NOXO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IEA,IBA --
GO:0010310 regulation of hydrogen peroxide metabolic process TAS 16636067
GO:0022617 extracellular matrix disassembly IMP 19755710
GO:0043085 positive regulation of catalytic activity IEA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with NOXO1: view

Drugs & Compounds for NOXO1 Gene

(3) Drugs for NOXO1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ecabet Approved, Investigational Pharma Target, antagonist 5
Hydrogen peroxide Pharma 48

(2) Additional Compounds for NOXO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NOXO1: view

Transcripts for NOXO1 Gene

mRNA/cDNA for NOXO1 Gene

Unigene Clusters for NOXO1 Gene

NADPH oxidase organizer 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for NOXO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOXO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for NOXO1 Gene

GeneLoc Exon Structure for
NOXO1
ECgene alternative splicing isoforms for
NOXO1

Expression for NOXO1 Gene

mRNA expression in normal human tissues for NOXO1 Gene

Protein differential expression in normal tissues from HIPED for NOXO1 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOXO1 Gene



Protein tissue co-expression partners for NOXO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOXO1 Gene:

NOXO1

SOURCE GeneReport for Unigene cluster for NOXO1 Gene:

Hs.191762

mRNA Expression by UniProt/SwissProt for NOXO1 Gene:

Q8NFA2-NOXO1_HUMAN
Tissue specificity: Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
genes like me logo Genes that share expression patterns with NOXO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOXO1 Gene

Orthologs for NOXO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC516233 34
  • 75.02 (n)
  • 68.8 (a)
NOXO1 35
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOXO1 34
  • 77.34 (n)
  • 71.87 (a)
NOXO1 35
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noxo1 34
  • 72.37 (n)
  • 70.57 (a)
Noxo1 16
Noxo1 35
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOXO1 34
  • 99.2 (n)
  • 98.94 (a)
NOXO1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noxo1 34
  • 75.39 (n)
  • 72.53 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia NOXO1 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOXO1 35
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii noxo1a 35
  • 24 (a)
OneToMany
noxo1b 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NOXO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXO1 Gene

ENSEMBL:
Gene Tree for NOXO1 (if available)
TreeFam:
Gene Tree for NOXO1 (if available)

Paralogs for NOXO1 Gene

Paralogs for NOXO1 Gene

genes like me logo Genes that share paralogs with NOXO1: view

Variants for NOXO1 Gene

Sequence variations from dbSNP and Humsavar for NOXO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34358073 -- 1,980,028(-) CAGGA(A/G)AGCCT reference, synonymous-codon
rs34505807 -- 1,980,689(-) TGCTG(C/T)GGAGA reference, missense
rs34644340 -- 1,981,939(+) TCAGG(A/G/T)AAGTG upstream-variant-2KB
rs35651739 -- 1,980,097(-) CAGAG(C/T)CTGCG reference, synonymous-codon
rs35927775 -- 1,981,479(+) AAGGG(-/G)CGAAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NOXO1 Gene

Variant ID Type Subtype PubMed ID
dgv336n27 CNV loss 19166990
dgv4858n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781
dgv4860n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160329 CNV deletion 26073780
nsv471070 CNV gain 18288195
nsv471072 CNV loss 18288195
nsv521569 CNV loss 19592680
nsv523037 CNV loss 19592680
nsv571179 CNV loss 21841781
nsv833120 CNV loss 17160897
nsv952901 CNV deletion 24416366

Variation tolerance for NOXO1 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOXO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOXO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOXO1 Gene

Disorders for NOXO1 Gene

Relevant External Links for NOXO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOXO1

No disorders were found for NOXO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOXO1 Gene

Publications for NOXO1 Gene

  1. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PMID: 16329988) Park H.S. … Bae Y.S. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 65
  2. Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. (PMID: 15949904) Cheng G. … Lambeth J.D. (Gene 2005) 3 4 22 65
  3. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. (PMID: 14617635) Cheng G. … Lambeth J.D. (J. Biol. Chem. 2004) 3 4 22 65
  4. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PMID: 12716910) Takeya R. … Sumimoto H. (J. Biol. Chem. 2003) 3 4 22 65
  5. Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1. (PMID: 20454568) Dutta S. … Rittinger K. (PLoS ONE 2010) 3 22 65

Products for NOXO1 Gene

Sources for NOXO1 Gene

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