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Aliases for NOXO1 Gene

Aliases for NOXO1 Gene

  • NADPH Oxidase Organizer 1 2 3
  • SH3 And PX Domain-Containing Protein 5 3 4
  • NADPH Oxidase Regulatory Protein 3 4
  • Nox-Organizing Protein 1 3 4
  • Nox Organizer 1 3 4
  • SH3PXD5 3 4
  • P41NOX 3 4
  • Regulatory Protein P41NOX 3
  • P41NOXA 3
  • P41NOXB 3
  • P41NOXC 3
  • SNX28 3

External Ids for NOXO1 Gene

Summaries for NOXO1 Gene

Entrez Gene Summary for NOXO1 Gene

  • This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for NOXO1 Gene

NOXO1 (NADPH Oxidase Organizer 1) is a Protein Coding gene. Among its related pathways are CDC42 signaling events. GO annotations related to this gene include phospholipid binding and phosphatidylinositol binding. An important paralog of this gene is SH3PXD2B.

UniProtKB/Swiss-Prot for NOXO1 Gene

  • Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

Gene Wiki entry for NOXO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXO1 Gene

Genomics for NOXO1 Gene

Genomic Location for NOXO1 Gene

Start:
1,978,917 bp from pter
End:
1,984,192 bp from pter
Size:
5,276 bases
Orientation:
Minus strand

Genomic View for NOXO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXO1 Gene

Regulatory Elements for NOXO1 Gene

Transcription factor binding sites by QIAGEN in the NOXO1 gene promoter:

Proteins for NOXO1 Gene

  • Protein details for NOXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFA2-NOXO1_HUMAN
    Recommended name:
    NADPH oxidase organizer 1
    Protein Accession:
    Q8NFA2
    Secondary Accessions:
    • Q86YM1
    • Q8NFA3
    • Q96B73

    Protein attributes for NOXO1 Gene

    Size:
    376 amino acids
    Molecular mass:
    41253 Da
    Quaternary structure:
    • Interacts with NOX1, NOXA1, CYBA/p22phox and NCF2/p67phox. Interacts with SH3PXD2A and SH3PXD2B.

    Three dimensional structures from OCA and Proteopedia for NOXO1 Gene

    Alternative splice isoforms for NOXO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXO1 Gene

Proteomics data for NOXO1 Gene at MOPED

Post-translational modifications for NOXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXO1 Gene

No data available for DME Specific Peptides for NOXO1 Gene

Domains for NOXO1 Gene

Protein Domains for NOXO1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NOXO1_HUMAN
Domain:
  • The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation:
    • Q8NFA2
  • The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region:
    • Q8NFA2
  • Contains 1 PX (phox homology) domain.:
    • Q8NFA2
  • Contains 2 SH3 domains.:
    • Q8NFA2
genes like me logo Genes that share domains with NOXO1: view

No data available for Gene Families for NOXO1 Gene

Function for NOXO1 Gene

Molecular function for NOXO1 Gene

UniProtKB/Swiss-Prot Function: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

Gene Ontology (GO) - Molecular Function for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16460309
GO:0005543 phospholipid binding TAS 16636067
GO:0016176 superoxide-generating NADPH oxidase activator activity TAS 16636067
GO:0019899 enzyme binding IPI 16636067
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with NOXO1: view

Phenotypes for NOXO1 Gene

genes like me logo Genes that share phenotypes with NOXO1: view

miRNA for NOXO1 Gene

miRTarBase miRNAs that target NOXO1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOXO1 Gene

Localization for NOXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOXO1 Gene

Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOXO1 Gene COMPARTMENTS Subcellular localization image for NOXO1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
peroxisome 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0043020 NADPH oxidase complex IDA 16636067
genes like me logo Genes that share ontologies with NOXO1: view

Pathways for NOXO1 Gene

SuperPathways for NOXO1 Gene

Superpath Contained pathways
1 CDC42 signaling events
genes like me logo Genes that share pathways with NOXO1: view

Pathways by source for NOXO1 Gene

1 BioSystems pathway for NOXO1 Gene

Gene Ontology (GO) - Biological Process for NOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0010310 regulation of hydrogen peroxide metabolic process TAS 16636067
GO:0022617 extracellular matrix disassembly IMP 19755710
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with NOXO1: view

Compounds for NOXO1 Gene

(1) HMDB Compounds for NOXO1 Gene

Compound Synonyms Cas Number PubMed IDs
Hydrogen peroxide
  • Hydrogen peroxide
7722-84-1

(1) Drugbank Compounds for NOXO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ecabet
86408-72-2 target antagonist

(3) Novoseek inferred chemical compound relationships for NOXO1 Gene

Compound -log(P) Hits PubMed IDs
nadph 78.9 8
superoxide 62.2 9
oxygen 33.7 1
genes like me logo Genes that share compounds with NOXO1: view

Transcripts for NOXO1 Gene

mRNA/cDNA for NOXO1 Gene

Unigene Clusters for NOXO1 Gene

NADPH oxidase organizer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOXO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for NOXO1 Gene

GeneLoc Exon Structure for
NOXO1
ECgene alternative splicing isoforms for
NOXO1

Expression for NOXO1 Gene

mRNA expression in normal human tissues for NOXO1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOXO1 Gene

SOURCE GeneReport for Unigene cluster for NOXO1 Gene Hs.191762

mRNA Expression by UniProt/SwissProt for NOXO1 Gene

Q8NFA2-NOXO1_HUMAN
Tissue specificity: Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis.
genes like me logo Genes that share expressions with NOXO1: view

Orthologs for NOXO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOXO1 36
  • 99.2 (n)
  • 98.94 (a)
NOXO1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC516233 36
  • 75.02 (n)
  • 68.8 (a)
NOXO1 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOXO1 36
  • 77.34 (n)
  • 71.87 (a)
NOXO1 37
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noxo1 36
  • 72.37 (n)
  • 70.57 (a)
Noxo1 16
Noxo1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOXO1 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noxo1 36
  • 75.39 (n)
  • 72.53 (a)
chicken
(Gallus gallus)
Aves NOXO1 37
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii noxo1a 37
  • 24 (a)
OneToMany
noxo1b 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for NOXO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXO1 Gene

ENSEMBL:
Gene Tree for NOXO1 (if available)
TreeFam:
Gene Tree for NOXO1 (if available)

Paralogs for NOXO1 Gene

Paralogs for NOXO1 Gene

genes like me logo Genes that share paralogs with NOXO1: view

Variants for NOXO1 Gene

Sequence variations from dbSNP and Humsavar for NOXO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8050552 -- 1,980,330(+) CAAAC(A/G)CCGCT intron-variant
rs12928922 -- 1,979,411(+) CACGC(A/C)CGCTC intron-variant
rs12929367 -- 1,979,722(+) CGGTG(C/T)TTCTG intron-variant
rs12933767 -- 1,979,787(+) GCGCA(C/T)ACCGC intron-variant
rs34358073 -- 1,980,028(-) CAGGA(A/G)AGCCT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for NOXO1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
nsv905076 CNV Gain 21882294
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2554n71 CNV Loss 21882294
nsv905082 CNV Loss 21882294

Relevant External Links for NOXO1 Gene

HapMap Linkage Disequilibrium report
NOXO1

Disorders for NOXO1 Gene

No disorders were found for NOXO1 Gene.

No data available for UniProtKB/Swiss-Prot for NOXO1 Gene

Publications for NOXO1 Gene

  1. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PMID: 12716910) Takeya R. … Sumimoto H. (J. Biol. Chem. 2003) 3 4 23
  2. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. (PMID: 14617635) Cheng G. … Lambeth J.D. (J. Biol. Chem. 2004) 3 4 23
  3. Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3. (PMID: 15949904) Cheng G. … Lambeth J.D. (Gene 2005) 3 4 23
  4. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PMID: 16329988) Park H.S. … Bae Y.S. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  5. Nox3 regulation by NOXO1, p47phox, and p67phox. (PMID: 15181005) Cheng G. … Lambeth J.D. (J. Biol. Chem. 2004) 3 23

Products for NOXO1 Gene

Sources for NOXO1 Gene

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