Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NOXA1 Gene

protein-coding   GIFtS: 55
GCID: GC09P140317

NADPH Oxidase Activator 1

(Previous name: serologically defined colon cancer antigen 31)
(Previous symbol: SDCCAG31)
  See NOXA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NADPH Oxidase Activator 11 2     NCF2-Like Protein2 3
SDCCAG311 2     p51-nox2 3
Serologically Defined Colon Cancer Antigen 311 2     NY-CO-312
Antigen NY-CO-312 3     Inhibitory NADPH Oxidase Activator 12
NOX Activator 12 3     p51NOX2
P67phox-Like Factor2 3     P51NOX3

External Ids:    HGNC: 106681   Entrez Gene: 108112   Ensembl: ENSG000001887477   OMIM: 6112555   UniProtKB: Q86UR13   

Export aliases for NOXA1 gene to outside databases

Previous GC identifers: GC00U905127 GC09U900274 GC09P9B0117 GC09P137593 GC09P139437 GC09P109781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOXA1 Gene:
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive
oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src
homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur
via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for NOXA1 Gene:
NOXA1 (NADPH oxidase activator 1) is a protein-coding gene. Diseases associated with NOXA1 include colon cancer. GO annotations related to this gene include Rac GTPase binding and enzyme binding. An important paralog of this gene is NCF2.

UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of
reactive oxygen species (ROS) which participate in a variety of biological processes including host defense,
hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3

Gene Wiki entry for NOXA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOXA1 gene promoter:
         c-Fos   AP-1   ATF-2   AP-4   E47   c-Myb   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOXA1 promoter sequence
   Search Chromatin IP Primers for NOXA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NOXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140317:  view genomic region     (about GC identifiers)

Start:
140,317,802 bp from pter      End:
140,328,858 bp from pter
Size:
11,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1 (See protein sequence)
Recommended Name: NADPH oxidase activator 1  
Size: 476 amino acids; 50933 Da
Subunit: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production.
Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes,
hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the
interaction is direct
Developmental stage: Expressed in fetal kidney
Sequence caution: Sequence=AAY16126.1; Type=Frameshift; Positions=305;
Secondary accessions: O60533 Q29VU9 Q29VV0 Q2TAM1 Q8IUS3
Alternative splicing: 3 isoforms:  Q86UR1-1   Q86UR1-2   Q86UR1-3   (Inactive for NOX1 activation. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOXA1: NX_Q86UR1

Explore proteomics data for NOXA1 at MOPED

Post-translational modifications: 

  • Interaction with YWHAZ depends on phosphorylation by PKA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOXA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001242996.1  NP_001242997.1  NP_006638.1  

    ENSEMBL proteins: 
     ENSP00000342848   ENSP00000376562  

    NOXA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NOXA1
    OriGene Protein Over-expression Lysate for NOXA1
    OriGene MassSpec for NOXA1
    OriGene Custom Protein Services for NOXA1
    GenScript Custom Purified and Recombinant Proteins Services for NOXA1
    Novus Biologicals NOXA1 Protein
    Novus Biologicals NOXA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOXA1

     
    Search eBioscience for Proteins for NOXA1 

    NOXA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NOXA1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NOXA1
    Novus Biologicals NOXA1 Antibodies
    Abcam antibodies for NOXA1
    Cloud-Clone Corp. Antibodies for NOXA1
    ThermoFisher Antibodies for NOXA1
    LSBio Antibodies in human, mouse, rat for NOXA1

    NOXA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOXA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOXA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOXA1
    Cloud-Clone Corp. CLIAs for NOXA1
    Search eBioscience for ELISAs for NOXA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR000270 OPR_PB1
     IPR011990 TPR-like_helical
     IPR001452 SH3_domain
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q86UR1

    ProtoNet protein and cluster: Q86UR1

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
    Domain: The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function
    Domain: The TPR repeats mediate interaction with RAC1
    Similarity: Belongs to the NCF2/NOXA1 family
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 4 TPR repeats


    Find genes that share domains with NOXA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOXA1_HUMAN, Q86UR1
    Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of
    reactive oxygen species (ROS) which participate in a variety of biological processes including host defense,
    hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16636067
    GO:0016176superoxide-generating NADPH oxidase activator activity IMP16636067
    GO:0017124SH3 domain binding IPI19755710
    GO:0019899enzyme binding IPI16636067
    GO:0048365Rac GTPase binding IPI16636067
         
    Find genes that share ontologies with NOXA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NOXA1:
     Decreased number of cells in m 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Noxa1):
     no phenotypic analysis  normal 

    Find genes that share phenotypes with NOXA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Noxa1tm1.2Brg for NOXA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOXA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOXA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOXA1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NOXA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NOXA1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOXA1
    Predesigned siRNA for gene silencing in human, mouse, rat NOXA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOXA1

    Clone
    Products:
         
    OriGene clones in human, mouse for NOXA1 (see all 7)
    OriGene ORF clones in mouse, rat for NOXA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOXA1 (NM_006647)
    Sino Biological Human cDNA Clone for NOXA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOXA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOXA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOXA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOXA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOXA1_HUMAN, Q86UR1: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe
    RAC1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043020NADPH oxidase complex IDA16636067

    Find genes that share ontologies with NOXA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NOXA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Prostate Cancer
    Prostate Cancer0.32
    Integrated Cancer pathway0.32
    2CDC42 signaling events
    RAC1 signaling pathway0.34
    3Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    4Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway
    5G protein signaling Rac2 regulation pathway
    G protein signaling Rac2 regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NOXA1
        G-protein signaling Rac2 regulation pathway

    5 BioSystems Pathways for NOXA1
        Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Prostate Cancer
    RAC1 signaling pathway
    Integrated Cancer pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOXA1
    Interactions:

        GeneGlobe Interaction Network for NOXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NOXA1 (Q86UR11, 2, 3 ENSP000003428484) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCGP051292, 3, ENSP000002634314MINT-2868748 I2D: score=3 STRING: ENSP00000263431
    NOXO1Q8NFA21, 2, 3, ENSP000003804504EBI-949814,EBI-7130806 MINT-8109369 I2D: score=3 STRING: ENSP00000380450
    YWHAZP631042, 3, ENSP000003095034MINT-8007978 MINT-8007971 I2D: score=1 STRING: ENSP00000309503
    NCF1P145983, ENSP000002894734I2D: score=1 STRING: ENSP00000289473
    NOX1Q9Y5S83, ENSP000003620574I2D: score=1 STRING: ENSP00000362057
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006801superoxide metabolic process IMP--
    GO:0010310regulation of hydrogen peroxide metabolic process IMP16636067
    GO:0043085positive regulation of catalytic activity IMP16636067
    GO:0060263regulation of respiratory burst IMP16636067

    Find genes that share ontologies with NOXA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOXA1

    2 HMDB Compounds for NOXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    3 Novoseek inferred chemical compound relationships for NOXA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 76.5 19 20110267 (3), 18568954 (2), 17913709 (1), 20083677 (1) (see all 8)
    superoxide 52.7 5 20083677 (1), 16472678 (1), 15326186 (1), 12473664 (1)
    oxygen 39.8 5 20083677 (2), 17913709 (1), 14617635 (1), 18568954 (1)



    Find genes that share compounds with NOXA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NOXA1 gene (3 alternative transcripts): 
    NM_001256067.1  NM_001256068.1  NM_006647.1  

    Unigene Cluster for NOXA1:

    NADPH oxidase activator 1
    Hs.495554  [show with all ESTs]
    Unigene Representative Sequence: BC110840
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341349(uc004cmu.3 uc004cmv.3 uc010nch.3) ENST00000392815

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOXA1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NOXA1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOXA1
    Predesigned siRNA for gene silencing in human, mouse, rat NOXA1
    Clone
    Products:
         
    OriGene clones in human, mouse for NOXA1 (see all 7)
    OriGene ORF clones in mouse, rat for NOXA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOXA1 (NM_006647)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOXA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOXA1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOXA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOXA1
      QuantiTect SYBR Green Assays in human, mouse, rat NOXA1
      QuantiFast Probe-based Assays in human, mouse, rat NOXA1

    Additional mRNA sequence: 

    AB095031.1 AF039697.1 AK098341.1 AY255769.1 AY927790.1 AY927791.1 BC041594.1 BC110840.1 

    6 DOTS entries:

    DT.100751185  DT.97804262  DT.100019568  DT.91788170  DT.65285887  DT.91796856 

    Selected AceView cDNA sequences (see all 41):

    CA391336 BX116780 BC041594 AY255769 AB095031 BQ066045 AI951401 AW515052 
    NM_006647 BU860557 AK055812 BQ216358 BI547214 CA391337 BI261835 BM927539 
    AI924807 AW081128 AK098341 BI753839 AA761660 AW081461 AF039697 BM544019 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NOXA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                      
    SP2:                    -                                                                                 


    ECgene alternative splicing isoforms for NOXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NOXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTTTAA
    NOXA1 Expression
    About this image

    NOXA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOXA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495554

    UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
    Tissue specificity: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and
    colon

        Custom PCR Arrays for NOXA1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOXA1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOXA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOXA1
    QuantiTect SYBR Green Assays in human, mouse, rat NOXA1
    QuantiFast Probe-based Assays in human, mouse, rat NOXA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NOXA1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noxa11 , 5 NADPH oxidase activator 11, 5 72.28(n)1
    66.59(a)1
      2 (16.97 cM)5
    2412751  NM_001163626.11  NP_001157098.11 
     250856675 
    chicken
    (Gallus gallus)
    Aves NOXA11 NADPH oxidase activator 1 59.58(n)
    49.14(a)
      417282  XM_004945755.1  XP_004945812.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia noxa11 NADPH oxidase activator 1 55.65(n)
    44.09(a)
      448279  NM_001005801.1  NP_001005801.1 
    zebrafish
    (Danio rerio)
    Actinopterygii noxa16
    NADPH oxidase activator 1
    32(a)
    1 ↔ 1
    5(30781287-30790954) ENSDARG00000056047


    ENSEMBL Gene Tree for NOXA1 (if available)
    TreeFam Gene Tree for NOXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NOXA1 gene
    NCF22  

    Find genes that share paralogs with NOXA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NOXA1 (see all 279)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886495641,2
    --109779832(+) TCAATG/TAATCC 3 -- int10--------
    rs1928107861,2
    --109780010(+) TACCTA/GTCTGA 3 -- int10--------
    rs1152528861,2
    C,F--140319860(+) TGAGAC/TGGAAT 3 -- int11Minor allele frequency- T:0.05WA 118
    rs1177763271,2
    F--140319874(+) GCTCTG/ATCTTG 3 -- int11Minor allele frequency- A:0.01NA 120
    rs1493499441,2
    C--140319909(+) CTTGGC/TTCACT 3 -- int10--------
    rs1869834171,2
    C--140319941(+) CAAGCA/GATTCT 3 -- int10--------
    rs1923190061,2
    --140319951(+) TCCTGC/TCTCAA 3 -- int10--------
    rs1814299051,2
    --140319983(+) CAGGCA/GCGTGC 3 -- int10--------
    rs1859588301,2
    --140319984(+) AGGCGC/TGTGCC 3 -- int10--------
    rs1900295801,2
    C--140320118(+) CAGGCC/GTGAGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for NOXA1 (140317802 - 140328858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NOXA1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675903CNV Deletion23128226
    nsv6771CNV Insertion18451855
    nsv894657CNV Loss21882294
    nsv894645CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8461n71CNV Loss21882294
    nsv894659CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894643CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOXA1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOXA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611255    OMIM disorders: --

    1 disease for NOXA1:    
    About MalaCards
    colon cancer


    Find genes that share disorders with NOXA1           About GenesLikeMe


    Export disorders for NOXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NOXA1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with NOXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J.... Old L.J. (Int. J. Cancer 1998)
    2. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PubMed id 17913709)1, 2, 9 Kim J.-S.... Bokoch G.M. (J. Biol. Chem. 2007)
    3. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PubMed id 12716910)1, 2, 9 Takeya R....Sumimoto H. (J. Biol. Chem. 2003)
    4. Direct interaction between Tks proteins and the N-terminal proline- rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PubMed id 20609497)1, 2 Gianni D.... Bokoch G.M. (Eur. J. Cell Biol. 2011)
    5. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2 Gianni D....Bokoch G.M. (Sci. Signal. 2009)
    6. NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. (PubMed id 17602954)1, 2 Valente A.J....Clark R.A. (Free Radic. Biol. Med. 2007)
    7. Nox1-dependent reactive oxygen generation is regulated by Rac1. (PubMed id 16636067)1, 2 Cheng G.... Lambeth J.D. (J. Biol. Chem. 2006)
    8. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. (PubMed id 12657628)1, 2 Geiszt M.... Leto T.L. (J. Biol. Chem. 2003)
    9. Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells. (PubMed id 18568954)1, 9 Honjo T....Inoue N. (Endothelium 2008)
    10. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. (PubMed id 20083677)1, 9 Niu X.L....Runge M.S. (Circulation 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10811 HGNC: 10668 AceView: NOXA1 Ensembl:ENSG00000188747 euGenes: HUgn10811
    ECgene: NOXA1 H-InvDB: NOXA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NOXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NOXA1 gene:
    Search GeneIP for patents involving NOXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NOXA1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NOXA1  
     OriGene qPCR primer pairs and template standards for NOXA1   OriGene Protein Over-expression Lysate for NOXA1  
     OriGene MassSpec something-or-other for NOXA1   OriGene clones in human, mouse for NOXA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOXA1   OriGene Purified Protein for NOXA1  
     OriGene ORF clones in mouse, rat for NOXA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOXA1   OriGene Custom Protein Services for NOXA1  

     
     
     Block miRNA regulation of human, mouse, rat NOXA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NOXA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOXA1 Predesigned siRNA for gene silencing in human, mouse, rat NOXA1
     QuantiFast Probe-based Assays in human, mouse, rat NOXA1 QuantiTect SYBR Green Assays in human, mouse, rat NOXA1
     Custom PCR Arrays for NOXA1 Search Chromatin IP Primers for NOXA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOXA1  GeneGlobe Interaction Network for NOXA1
     Regulatory tfbs in NOXA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NOXA1 GenScript cDNA clones with any tag delivered in your preferred vector for NOXA1
     GenScript Custom Assay Services for NOXA1 GenScript Custom overexpressing Cell Line Services for NOXA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NOXA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NOXA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NOXA1 antibodies
     NOXA1 proteins
     NOXA1 lysates
     Antibodies for NOXA1
     See all of Abcam's Antibodies, Kits and Proteins for NOXA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NOXA1
     Antibodies for NOXA1
     ELISAs for NOXA1
     CLIAs for NOXA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NOXA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOXA1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NOXA1
     SwitchGear Promoter luciferase reporter plasmids for NOXA1
     ThermoFisher Antibodies for NOXA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOXA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOXA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOXA1
     LSBio Antibodies in human, mouse, rat for NOXA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NOXA1
      Search eBioscience for proteins for NOXA1
      Search eBioscience for elisas for NOXA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOXA1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4