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Aliases for NOXA1 Gene

Aliases for NOXA1 Gene

  • NADPH Oxidase Activator 1 2 3
  • Serologically Defined Colon Cancer Antigen 31 2 3
  • P67phox-Like Factor 3 4
  • NCF2-Like Protein 3 4
  • Antigen NY-CO-31 3 4
  • P51-Nox 3 4
  • P51NOX 3 4
  • Inhibitory NADPH Oxidase Activator 1 3
  • Nox Activator 1 3
  • NOX Activator 1 4
  • NY-CO-31 3
  • SDCCAG31 3

External Ids for NOXA1 Gene

Previous Symbols for NOXA1 Gene

  • SDCCAG31

Summaries for NOXA1 Gene

Entrez Gene Summary for NOXA1 Gene

  • This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for NOXA1 Gene

NOXA1 (NADPH Oxidase Activator 1) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and CDC42 signaling events. GO annotations related to this gene include enzyme binding and Rac GTPase binding. An important paralog of this gene is NCF2.

UniProtKB/Swiss-Prot for NOXA1 Gene

  • Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Gene Wiki entry for NOXA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXA1 Gene

Genomics for NOXA1 Gene

Genomic Location for NOXA1 Gene

137,423,350 bp from pter
137,434,467 bp from pter
11,118 bases
Plus strand

Genomic View for NOXA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOXA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXA1 Gene

Regulatory Elements for NOXA1 Gene

Proteins for NOXA1 Gene

  • Protein details for NOXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADPH oxidase activator 1
    Protein Accession:
    Secondary Accessions:
    • O60533
    • Q29VU9
    • Q29VV0
    • Q2TAM1
    • Q8IUS3

    Protein attributes for NOXA1 Gene

    476 amino acids
    Molecular mass:
    50933 Da
    Quaternary structure:
    • NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.
    • Sequence=AAY16126.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305};

    Alternative splice isoforms for NOXA1 Gene


neXtProt entry for NOXA1 Gene

Proteomics data for NOXA1 Gene at MOPED

Post-translational modifications for NOXA1 Gene

Other Protein References for NOXA1 Gene

No data available for DME Specific Peptides for NOXA1 Gene

Domains for NOXA1 Gene

Protein Domains for NOXA1 Gene


  • The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function:
    • Q86UR1
  • The TPR repeats mediate interaction with RAC1:
    • Q86UR1
  • Contains 1 PB1 domain.:
    • Q86UR1
  • Contains 1 SH3 domain.:
    • Q86UR1
  • Belongs to the NCF2/NOXA1 family.:
    • Q86UR1
  • Contains 4 TPR repeats.:
    • Q86UR1
genes like me logo Genes that share domains with NOXA1: view

No data available for Gene Families for NOXA1 Gene

Function for NOXA1 Gene

Molecular function for NOXA1 Gene

UniProtKB/Swiss-Prot Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Gene Ontology (GO) - Molecular Function for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16636067
GO:0016176 superoxide-generating NADPH oxidase activator activity IMP 16636067
GO:0017124 SH3 domain binding IPI 19755710
GO:0019899 enzyme binding IPI 16636067
GO:0048365 Rac GTPase binding IPI 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Phenotypes for NOXA1 Gene

genes like me logo Genes that share phenotypes with NOXA1: view

Animal Models for NOXA1 Gene

MGI Knock Outs for NOXA1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NOXA1 Gene

Localization for NOXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOXA1 Gene

Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Subcellular locations from

Jensen Localization Image for NOXA1 Gene COMPARTMENTS Subcellular localization image for NOXA1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0043020 NADPH oxidase complex IDA 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Pathways for NOXA1 Gene

genes like me logo Genes that share pathways with NOXA1: view

Pathways by source for NOXA1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for NOXA1 Gene

Gene Ontology (GO) - Biological Process for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IMP 20609497
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0010310 regulation of hydrogen peroxide metabolic process IMP 16636067
GO:0043085 positive regulation of catalytic activity IEA --
GO:0060263 regulation of respiratory burst IMP 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Compounds for NOXA1 Gene

(2) HMDB Compounds for NOXA1 Gene

Compound Synonyms Cas Number PubMed IDs
Hydrogen peroxide
  • Hydrogen peroxide
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide

(3) Novoseek inferred chemical compound relationships for NOXA1 Gene

Compound -log(P) Hits PubMed IDs
nadph 76.5 11
superoxide 52.7 4
oxygen 39.8 5
genes like me logo Genes that share compounds with NOXA1: view

Transcripts for NOXA1 Gene

Unigene Clusters for NOXA1 Gene

NADPH oxidase activator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP2: -

Relevant External Links for NOXA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOXA1 Gene

mRNA expression in normal human tissues for NOXA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NOXA1 Gene

SOURCE GeneReport for Unigene cluster for NOXA1 Gene Hs.495554

mRNA Expression by UniProt/SwissProt for NOXA1 Gene

Tissue specificity: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
genes like me logo Genes that share expressions with NOXA1: view

Orthologs for NOXA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOXA1 36
  • 99.16 (n)
  • 99.16 (a)
NOXA1 37
  • 99 (a)
(Bos Taurus)
Mammalia NOXA1 36
  • 82.47 (n)
  • 72.41 (a)
NOXA1 37
  • 64 (a)
(Canis familiaris)
Mammalia NOXA1 36
  • 83.93 (n)
  • 76.79 (a)
NOXA1 37
  • 65 (a)
(Mus musculus)
Mammalia Noxa1 36
  • 72.28 (n)
  • 66.59 (a)
Noxa1 16
Noxa1 37
  • 61 (a)
(Monodelphis domestica)
Mammalia NOXA1 37
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia NOXA1 37
  • 41 (a)
(Rattus norvegicus)
Mammalia Noxa1 36
  • 69.98 (n)
  • 62.53 (a)
(Gallus gallus)
Aves NOXA1 36
  • 59.58 (n)
  • 49.14 (a)
NOXA1 37
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia noxa1 36
  • 55.65 (n)
  • 44.09 (a)
(Danio rerio)
Actinopterygii noxa1 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
Species with no ortholog for NOXA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXA1 Gene

Gene Tree for NOXA1 (if available)
Gene Tree for NOXA1 (if available)

Paralogs for NOXA1 Gene

Paralogs for NOXA1 Gene

genes like me logo Genes that share paralogs with NOXA1: view

Variants for NOXA1 Gene

Sequence variations from dbSNP and Humsavar for NOXA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9414734 -- 137,426,165(-) ACAGG(A/G)CCACG intron-variant, upstream-variant-2KB
rs9694983 -- 137,429,911(+) TGTGT(C/G)CCTGC intron-variant
rs9802418 -- 137,430,192(+) GGGGC(A/G)GGGGC intron-variant
rs9802473 -- 137,430,075(+) GCCTG(C/T)GTCCC intron-variant
rs11522284 -- 137,425,720(+) GGGAT(C/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOXA1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894643 CNV Loss 21882294
nsv894645 CNV Loss 21882294
dgv2428e1 CNV Complex 17122850
nsv894653 CNV Gain 21882294
dgv8460n71 CNV Loss 21882294
nsv894657 CNV Loss 21882294
nsv894658 CNV Loss 21882294
nsv894659 CNV Loss 21882294
nsv894660 CNV Loss 21882294
nsv6771 CNV Insertion 18451855
dgv8461n71 CNV Loss 21882294
esv2675903 CNV Deletion 23128226

Relevant External Links for NOXA1 Gene

HapMap Linkage Disequilibrium report

Disorders for NOXA1 Gene

No disorders were found for NOXA1 Gene.

No data available for UniProtKB/Swiss-Prot for NOXA1 Gene

Publications for NOXA1 Gene

  1. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PMID: 12716910) Takeya R. … Sumimoto H. (J. Biol. Chem. 2003) 3 4 23
  2. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PMID: 17913709) Kim J.-S. … Bokoch G.M. (J. Biol. Chem. 2007) 3 4 23
  3. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  4. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. (PMID: 20083677) Niu X.L. … Runge M.S. (Circulation 2010) 3 23
  5. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. (PMID: 20110267) Kroviarski Y. … Dang P.M. (FASEB J. 2010) 3 23

Products for NOXA1 Gene

Sources for NOXA1 Gene

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