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Aliases for NOXA1 Gene

Aliases for NOXA1 Gene

  • NADPH Oxidase Activator 1 2 3 5
  • Serologically Defined Colon Cancer Antigen 31 2 3
  • P67phox-Like Factor 3 4
  • NCF2-Like Protein 3 4
  • Antigen NY-CO-31 3 4
  • P51-Nox 3 4
  • P51NOX 3 4
  • Inhibitory NADPH Oxidase Activator 1 3
  • Nox Activator 1 3
  • NOX Activator 1 4
  • NY-CO-31 3
  • SDCCAG31 3

External Ids for NOXA1 Gene

Previous HGNC Symbols for NOXA1 Gene

  • SDCCAG31

Previous GeneCards Identifiers for NOXA1 Gene

  • GC00U905127
  • GC09U900274
  • GC09P9B0117
  • GC09P137593
  • GC09P139437
  • GC09P140317
  • GC09P109781

Summaries for NOXA1 Gene

Entrez Gene Summary for NOXA1 Gene

  • This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for NOXA1 Gene

NOXA1 (NADPH Oxidase Activator 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include enzyme binding and Rac GTPase binding. An important paralog of this gene is NCF2.

UniProtKB/Swiss-Prot for NOXA1 Gene

  • Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Gene Wiki entry for NOXA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXA1 Gene

Genomics for NOXA1 Gene

Regulatory Elements for NOXA1 Gene

Enhancers for NOXA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOXA1 on UCSC Golden Path with GeneCards custom track

Promoters for NOXA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NOXA1 Gene

Chromosome:
9
Start:
137,423,350 bp from pter
End:
137,434,406 bp from pter
Size:
11,057 bases
Orientation:
Plus strand

Genomic View for NOXA1 Gene

Genes around NOXA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXA1 Gene

Proteins for NOXA1 Gene

  • Protein details for NOXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UR1-NOXA1_HUMAN
    Recommended name:
    NADPH oxidase activator 1
    Protein Accession:
    Q86UR1
    Secondary Accessions:
    • O60533
    • Q29VU9
    • Q29VV0
    • Q2TAM1
    • Q8IUS3

    Protein attributes for NOXA1 Gene

    Size:
    476 amino acids
    Molecular mass:
    50933 Da
    Quaternary structure:
    • NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.
    SequenceCaution:
    • Sequence=AAY16126.1; Type=Frameshift; Positions=305; Evidence={ECO:0000305};

    Alternative splice isoforms for NOXA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXA1 Gene

Post-translational modifications for NOXA1 Gene

Other Protein References for NOXA1 Gene

No data available for DME Specific Peptides for NOXA1 Gene

Domains & Families for NOXA1 Gene

Protein Domains for NOXA1 Gene

Suggested Antigen Peptide Sequences for NOXA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UR1

UniProtKB/Swiss-Prot:

NOXA1_HUMAN :
  • The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
  • Belongs to the NCF2/NOXA1 family.
  • Contains 4 TPR repeats.
Domain:
  • The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
  • The TPR repeats mediate interaction with RAC1.
  • Contains 1 PB1 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the NCF2/NOXA1 family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with NOXA1: view

No data available for Gene Families for NOXA1 Gene

Function for NOXA1 Gene

Molecular function for NOXA1 Gene

UniProtKB/Swiss-Prot Function:
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Gene Ontology (GO) - Molecular Function for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16636067
GO:0016176 superoxide-generating NADPH oxidase activator activity IMP 16636067
GO:0017124 SH3 domain binding IPI 19755710
GO:0019899 enzyme binding IPI 16636067
GO:0048365 Rac GTPase binding IPI 16636067
genes like me logo Genes that share ontologies with NOXA1: view
genes like me logo Genes that share phenotypes with NOXA1: view

Animal Models for NOXA1 Gene

MGI Knock Outs for NOXA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NOXA1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NOXA1 Gene

Localization for NOXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOXA1 Gene

Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOXA1 Gene COMPARTMENTS Subcellular localization image for NOXA1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043020 NADPH oxidase complex IDA 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Pathways & Interactions for NOXA1 Gene

genes like me logo Genes that share pathways with NOXA1: view

SIGNOR curated interactions for NOXA1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IMP 20609497
GO:0010310 regulation of hydrogen peroxide metabolic process IMP 16636067
GO:0043085 positive regulation of catalytic activity IEA --
GO:0060263 regulation of respiratory burst IMP 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Drugs & Compounds for NOXA1 Gene

(2) Drugs for NOXA1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrogen peroxide Pharma 48

(2) Additional Compounds for NOXA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with NOXA1: view

Transcripts for NOXA1 Gene

Unigene Clusters for NOXA1 Gene

NADPH oxidase activator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NOXA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -

Relevant External Links for NOXA1 Gene

GeneLoc Exon Structure for
NOXA1
ECgene alternative splicing isoforms for
NOXA1

Expression for NOXA1 Gene

mRNA expression in normal human tissues for NOXA1 Gene

Protein differential expression in normal tissues from HIPED for NOXA1 Gene

This gene is overexpressed in Cerebrospinal fluid (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOXA1 Gene



Protein tissue co-expression partners for NOXA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOXA1 Gene:

NOXA1

SOURCE GeneReport for Unigene cluster for NOXA1 Gene:

Hs.495554

mRNA Expression by UniProt/SwissProt for NOXA1 Gene:

Q86UR1-NOXA1_HUMAN
Tissue specificity: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
genes like me logo Genes that share expression patterns with NOXA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOXA1 Gene

Orthologs for NOXA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOXA1 34
  • 82.47 (n)
  • 72.41 (a)
NOXA1 35
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOXA1 34
  • 83.93 (n)
  • 76.79 (a)
NOXA1 35
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noxa1 34
  • 72.28 (n)
  • 66.59 (a)
Noxa1 16
Noxa1 35
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOXA1 34
  • 99.16 (n)
  • 99.16 (a)
NOXA1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noxa1 34
  • 69.98 (n)
  • 62.53 (a)
oppossum
(Monodelphis domestica)
Mammalia NOXA1 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOXA1 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOXA1 34
  • 59.58 (n)
  • 49.14 (a)
NOXA1 35
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noxa1 34
  • 55.65 (n)
  • 44.09 (a)
zebrafish
(Danio rerio)
Actinopterygii noxa1 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NOXA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXA1 Gene

ENSEMBL:
Gene Tree for NOXA1 (if available)
TreeFam:
Gene Tree for NOXA1 (if available)

Paralogs for NOXA1 Gene

Paralogs for NOXA1 Gene

genes like me logo Genes that share paralogs with NOXA1: view

Variants for NOXA1 Gene

Sequence variations from dbSNP and Humsavar for NOXA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs34155071 - 137,433,211(+) GCTGC(C/T)GGCAA reference, missense
rs9414734 -- 137,426,165(-) ACAGG(A/G)CCACG intron-variant
rs9694983 -- 137,429,911(+) TGTGT(C/G)CCTGC intron-variant
rs9695429 -- 137,429,663(+) CTGGG(C/T)CATGG intron-variant
rs9697151 -- 137,429,454(+) GGATG(C/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOXA1 Gene

Variant ID Type Subtype PubMed ID
esv2675903 CNV deletion 23128226
esv2759721 CNV loss 17122850
esv3573431 CNV loss 25503493
esv3622034 CNV gain 21293372
nsv1049808 CNV gain 25217958
nsv1075290 CNV deletion 25765185
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv6771 CNV insertion 18451855
nsv951208 CNV deletion 24416366

Variation tolerance for NOXA1 Gene

Gene Damage Index Score: 5.35; 70.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOXA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOXA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOXA1 Gene

Disorders for NOXA1 Gene

Relevant External Links for NOXA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOXA1

No disorders were found for NOXA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOXA1 Gene

Publications for NOXA1 Gene

  1. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PMID: 17913709) Kim J.-S. … Bokoch G.M. (J. Biol. Chem. 2007) 3 4 22 65
  2. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PMID: 12716910) Takeya R. … Sumimoto H. (J. Biol. Chem. 2003) 3 4 22 65
  3. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4 65
  4. Direct interaction between Tks proteins and the N-terminal proline- rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PMID: 20609497) Gianni D. … Bokoch G.M. (Eur. J. Cell Biol. 2011) 3 4 65
  5. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. (PMID: 20083677) Niu X.L. … Runge M.S. (Circulation 2010) 3 22 65

Products for NOXA1 Gene

Sources for NOXA1 Gene

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