Aliases for NOXA1 Gene
External Ids for NOXA1 Gene
Previous HGNC Symbols for NOXA1 Gene
Previous GeneCards Identifiers for NOXA1 Gene
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for NOXA1 Gene
NOXA1 (NADPH Oxidase Activator 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and G-protein signaling_Rac2 regulation pathway. GO annotations related to this gene include enzyme binding and Rac GTPase binding. An important paralog of this gene is NCF2.
UniProtKB/Swiss-Prot for NOXA1 Gene
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.