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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOXA1 Gene

protein-coding   GIFtS: 56
GCID: GC09P140317

NADPH Oxidase Activator 1

(Previous name: serologically defined colon cancer antigen 31)
(Previous symbol: SDCCAG31)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADPH Oxidase Activator 11 2     NCF2-Like Protein2 3
SDCCAG311 2     p51-nox2 3
Serologically Defined Colon Cancer Antigen 311 2     NY-CO-312
Antigen NY-CO-312 3     Inhibitory NADPH Oxidase Activator 12
NOX Activator 12 3     p51NOX2
P67phox-Like Factor2 3     P51NOX3

External Ids:    HGNC: 106681   Entrez Gene: 108112   Ensembl: ENSG000001887477   OMIM: 6112555   UniProtKB: Q86UR13   

Export aliases for NOXA1 gene to outside databases

Previous GC identifers: GC00U905127 GC09U900274 GC09P9B0117 GC09P137593 GC09P139437 GC09P109781


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOXA1 Gene:
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive
oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src
homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur
via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for NOXA1 Gene: 
NOXA1 (NADPH oxidase activator 1) is a protein-coding gene. Diseases associated with NOXA1 include colon cancer, and macular degeneration, and among its related super-pathways are Integrated Cancer pathway and G-protein signaling Rac2 regulation pathway. GO annotations related to this gene include Rac GTPase binding and enzyme binding. An important paralog of this gene is NCF2.

UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of
reactive oxygen species (ROS) which participate in a variety of biological processes including host defense,
hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3

Gene Wiki entry for NOXA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOXA1 gene promoter:
         c-Fos   AP-1   ATF-2   AP-4   E47   c-Myb   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOXA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOXA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOXA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NOXA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOXA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140317:  view genomic region     (about GC identifiers)

Start:
140,317,802 bp from pter      End:
140,328,858 bp from pter
Size:
11,057 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1 (See protein sequence)
Recommended Name: NADPH oxidase activator 1  
Size: 476 amino acids; 50933 Da
Subunit: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production.
Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes,
hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the
interaction is direct
Subcellular location: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe
RAC1
Developmental stage: Expressed in fetal kidney
Sequence caution: Sequence=AAY16126.1; Type=Frameshift; Positions=305;
Secondary accessions: O60533 Q29VU9 Q29VV0 Q2TAM1 Q8IUS3
Alternative splicing: 3 isoforms:  Q86UR1-1   Q86UR1-2   Q86UR1-3   (Inactive for NOX1 activation. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOXA1: NX_Q86UR1

Explore proteomics data for NOXA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Interaction with YWHAZ depends on phosphorylation by PKA
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UR1

  • NOXA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOXA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001242996.1  NP_001242997.1  NP_006638.1  

    ENSEMBL proteins: 
     ENSP00000342848   ENSP00000376562  

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    Cloud-Clone Corp. Proteins for NOXA1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043020NADPH oxidase complex IDA16636067

    NOXA1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for NOXA1 
    Cloud-Clone Corp. CLIAs for NOXA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR000108 p67phox
     IPR001452 SH3_domain
     IPR000270 OPR_PB1
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q86UR1

    ProtoNet protein and cluster: Q86UR1

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
    Domain: The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function
    Domain: The TPR repeats mediate interaction with RAC1
    Similarity: Belongs to the NCF2/NOXA1 family
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 4 TPR repeats


    NOXA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOXA1_HUMAN, Q86UR1
    Function: Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of
    reactive oxygen species (ROS) which participate in a variety of biological processes including host defense,
    hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16636067
    GO:0016176superoxide-generating NADPH oxidase activator activity IMP16636067
    GO:0017124SH3 domain binding IPI19755710
    GO:0019899enzyme binding IPI16636067
    GO:0048365Rac GTPase binding IPI16636067
         
    NOXA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOXA1:
     Decreased number of cells in m 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Noxa1):
     no phenotypic analysis  normal 

    NOXA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Noxa1tm1.2Brg for NOXA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOXA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOXA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOXA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOXA1 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOXA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Prostate Cancer
    Integrated Cancer pathway0.32
    Prostate Cancer0.32
    2G-protein signaling Rac2 regulation pathway
    G-protein signaling Rac2 regulation pathway1.00
    3CDC42 signaling events
    RAC1 signaling pathway0.34
    4Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NOXA1
        G-protein signaling Rac2 regulation pathway


    1 GeneGo (Thomson Reuters) Pathway for NOXA1
        G-protein signaling Rac2 regulation pathway

    5 BioSystems Pathways for NOXA1
        Integrated Breast Cancer Pathway
    Prostate Cancer
    Integrated Pancreatic Cancer Pathway
    RAC1 signaling pathway
    Integrated Cancer pathway



    NOXA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOXA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/22 Interacting proteins for NOXA1 (Q86UR12, 3 ENSP000003428484) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCGP051292, 3, ENSP000002634314MINT-2868748 I2D: score=3 STRING: ENSP00000263431
    YWHAZP631042, 3, ENSP000003095034MINT-8007978 MINT-8007971 I2D: score=1 STRING: ENSP00000309503
    NOXO1Q8NFA22, 3, ENSP000003804504MINT-8109369 I2D: score=3 STRING: ENSP00000380450
    NCF1P145983, ENSP000002894734I2D: score=1 STRING: ENSP00000289473
    NOX1Q9Y5S83, ENSP000003620574I2D: score=1 STRING: ENSP00000362057
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006801superoxide metabolic process IMP--
    GO:0010310regulation of hydrogen peroxide metabolic process IMP16636067
    GO:0060263regulation of respiratory burst IMP16636067

    NOXA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOXA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NOXA1

    2 HMDB Compounds for NOXA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    3 Novoseek inferred chemical compound relationships for NOXA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 76.5 19 20110267 (3), 18568954 (2), 17913709 (1), 20083677 (1) (see all 8)
    superoxide 52.7 5 20083677 (1), 16472678 (1), 15326186 (1), 12473664 (1)
    oxygen 39.8 5 20083677 (2), 17913709 (1), 14617635 (1), 18568954 (1)

    Search CenterWatch for drugs/clinical trials and news about NOXA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOXA1 gene (3 alternative transcripts): 
    NM_001256067.1  NM_001256068.1  NM_006647.1  

    Unigene Cluster for NOXA1:

    NADPH oxidase activator 1
    Hs.495554  [show with all ESTs]
    Unigene Representative Sequence: BC110840
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341349(uc004cmu.3 uc004cmv.3 uc010nch.3) ENST00000392815

    miRNA
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    Additional mRNA sequence: 

    AB095031.1 AF039697.1 AK098341.1 AY255769.1 AY927790.1 AY927791.1 BC041594.1 BC110840.1 

    6 DOTS entries:

    DT.100751185  DT.97804262  DT.100019568  DT.91788170  DT.65285887  DT.91796856 

    24/41 AceView cDNA sequences (see all 41):

    AB095031 BC041594 AY255769 AI951401 BQ066045 NM_006647 CA391336 BX116780 
    AW515052 CA391337 AW081128 BM927539 BU860557 BI547214 AK055812 BI261835 
    AI924807 AK098341 BQ216358 AA761660 BM544019 AW083532 R49969 BI763047 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NOXA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                      
    SP2:                    -                                                                                 


    ECgene alternative splicing isoforms for NOXA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOXA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTTTAA
    NOXA1 Expression
    About this image


    See NOXA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOXA1

    SOURCE GeneReport for Unigene cluster: Hs.495554

    UniProtKB/Swiss-Prot: NOXA1_HUMAN, Q86UR1
    Tissue specificity: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and
    colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOXA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NOXA1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noxa11 , 5 NADPH oxidase activator 11, 5 72.69(n)1
    65.73(a)1
      2 (16.97 cM)5
    2412751  NM_172204.41  NP_757341.31 
     250856675 
    chicken
    (Gallus gallus)
    Aves NOXA11 NADPH oxidase activator 1 55.71(n)
    43.92(a)
      417282  XM_415555.3  XP_415555.3 
    zebrafish
    (Danio rerio)
    Actinopterygii noxa16
    NADPH oxidase activator 1
    29(a)
    1 ↔ 1
    5(30781287-30790954)


    ENSEMBL Gene Tree for NOXA1 (if available)
    TreeFam Gene Tree for NOXA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOXA1 gene
    NCF22  

    NOXA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/279 SNPs in NOXA1 are shown (see all 279)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886495641,2
    --109779832(+) TCAATG/TAATCC 3 -- int10--------
    rs1928107861,2
    --109780010(+) TACCTA/GTCTGA 3 -- int10--------
    rs1152528861,2
    C,F--140319860(+) TGAGAC/TGGAAT 3 -- int11Minor allele frequency- T:0.05WA 118
    rs1177763271,2
    F--140319874(+) GCTCTG/ATCTTG 3 -- int11Minor allele frequency- A:0.01NA 120
    rs1493499441,2
    C--140319909(+) CTTGGC/TTCACT 3 -- int10--------
    rs1869834171,2
    C--140319941(+) CAAGCA/GATTCT 3 -- int10--------
    rs1923190061,2
    --140319951(+) TCCTGC/TCTCAA 3 -- int10--------
    rs1814299051,2
    --140319983(+) CAGGCA/GCGTGC 3 -- int10--------
    rs1859588301,2
    --140319984(+) AGGCGC/TGTGCC 3 -- int10--------
    rs1900295801,2
    C--140320118(+) CAGGCC/GTGAGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for NOXA1 (140317802 - 140328858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for NOXA1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675903CNV Deletion23128226
    nsv6771CNV Insertion18451855
    nsv894657CNV Loss21882294
    nsv894645CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8461n71CNV Loss21882294
    nsv894659CNV Loss21882294
    dgv8423n71CNV Loss21882294
    nsv894643CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611255    OMIM disorders: --

    8 diseases for NOXA1:    About MalaCards
    colon cancer    macular degeneration    ataxia    pancreatic cancer
    endotheliitis    pancreatitis    prostatitis    breast cancer


    NOXA1 for disorders           About GeneDecksing


    Export disorders for NOXA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOXA1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with NOXA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J....Old L.J. (1998)
    2. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PubMed id 17913709)1, 2, 9 Kim J.-S.... Bokoch G.M. (2007)
    3. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PubMed id 12716910)1, 2, 9 Takeya R....Sumimoto H. (2003)
    4. Direct interaction between Tks proteins and the N-terminal proline- rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PubMed id 20609497)1, 2 Gianni D.... Bokoch G.M. (2011)
    5. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2 Gianni D....Bokoch G.M. (2009)
    6. NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. (PubMed id 17602954)1, 2 Valente A.J....Clark R.A. (2007)
    7. Nox1-dependent reactive oxygen generation is regulated by Rac1. (PubMed id 16636067)1, 2 Cheng G.... Lambeth J.D. (2006)
    8. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. (PubMed id 12657628)1, 2 Geiszt M.... Leto T.L. (2003)
    9. Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells. (PubMed id 18568954)1, 9 Honjo T....Inoue N. (2008)
    10. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. (PubMed id 20083677)1, 9 Niu X.L....Runge M.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10811 HGNC: 10668 AceView: NOXA1 Ensembl:ENSG00000188747 euGenes: HUgn10811
    ECgene: NOXA1 H-InvDB: NOXA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOXA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOXA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOXA1 gene:
    Search GeneIP for patents involving NOXA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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