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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOX5 Gene

protein-coding   GIFtS: 49
GCID: GC15P069222

NADPH Oxidase, EF-Hand Calcium Binding Domain 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADPH Oxidase, EF-Hand Calcium Binding Domain 51 2
NADPH Oxidase 52
EC 1.6.3.-3
NOX5A5
NOX5B5

External Ids:    HGNC: 148741   Entrez Gene: 794002   Ensembl: ENSG000002553467   OMIM: 6065725   UniProtKB: Q96PH13   

Export aliases for NOX5 gene to outside databases

Previous GC identifers: GC15P065065 GC15P062322 GC15P066801 GC15P066939 GC15P066940 GC15P067009 GC15P046055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOX5 Gene:
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes
a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel
that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for NOX5 Gene: 
NOX5 (NADPH oxidase, EF-hand calcium binding domain 5) is a protein-coding gene. Diseases associated with NOX5 include esophageal adenocarcinoma, and chronic granulomatous disease, and among its related super-pathways are PPAR Pathway and PAK Pathway. GO annotations related to this gene include flavin adenine dinucleotide binding and calcium ion binding. An important paralog of this gene is CYBB.

UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
Function: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton
channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth
and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS),
proliferation and angiogenesis and contribute to endothelial response to thrombin

Gene Wiki entry for NOX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOX5 gene promoter:
         RFX1   MIF-1   HNF-4alpha2   Evi-1   HNF-4alpha1   POU2F1   POU2F1b   POU2F1a   HOXA5   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.31

NOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P069222:  view genomic region     (about GC identifiers)

Start:
69,222,839 bp from pter      End:
69,355,083 bp from pter
Size:
132,245 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1 (See protein sequence)
Recommended Name: NADPH oxidase 5  
Size: 765 amino acids; 86439 Da
Cofactor: FAD
Cofactor: Magnesium
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform v2: Endoplasmic reticulum
Subcellular location: Isoform v5: Endoplasmic reticulum
Developmental stage: Expressed in fetal tissues
Sequence caution: Sequence=AAG33638.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15319.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB84897.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RBJ4 Q08AN2 Q08AN3 Q8TEQ1 Q8TER4 Q96PH2 Q96PJ8 Q96PJ9 Q9H6E0 Q9HAM8
Alternative splicing: 6 isoforms:  Q96PH1-1   Q96PH1-3   Q96PH1-4   Q96PH1-2   Q96PH1-5   Q96PH1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOX5: NX_Q96PH1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PH1

  • NOX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171708.1  NP_001171709.1  NP_078781.3  

    ENSEMBL proteins: 
     ENSP00000410887   ENSP00000454143   ENSP00000416828   ENSP00000373518   ENSP00000432440  
     ENSP00000455703  

    Human Recombinant Protein Products for NOX5: 
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    OriGene Protein Over-expression Lysate for NOX5
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    Novus Biologicals NOX5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOX5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral to membrane IEA--

    NOX5 for ontologies           About GeneDecksing



    NOX5 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for NOX5 

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    Cloud-Clone Corp. ELISAs for NOX5 
    Cloud-Clone Corp. CLIAs for NOX5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/8 InterPro protein domains (see all 8):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR013121 Fe_red_NAD-bd_6
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96PH1

    ProtoNet protein and cluster: Q96PH1

    1 Blocks protein domain: IPB013130 Ferric reductase-like transmembrane component

    UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
    Domain: Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3
    and isoform v4 have the third EF-hand domain interrupted by an insert
    Similarity: Contains 4 EF-hand domains
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 ferric oxidoreductase domain


    NOX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOX5_HUMAN, Q96PH1
    Function: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton
    channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth
    and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS),
    proliferation and angiogenesis and contribute to endothelial response to thrombin
    Enzyme regulation: Activated by calcium which induces conformational changes and interaction between the
    N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium
    Biophysicochemical properties: Kinetic parameters: KM=1.06 uM for calcium;
    Induction: Down-regulated by TGFB1

         Enzyme Number (IUBMB): EC 1.6.3.-1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17346712
    GO:0015252hydrogen ion channel activity IDA11483596
    GO:0016175superoxide-generating NADPH oxidase activity IDA11483596
    GO:0016491oxidoreductase activity ----
         
    NOX5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOX5:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOX5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOX5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOX5 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NOX5:
    hsa-miR-485-5p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidNOX5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOX5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NOX5
        Rac1 Pathway
    Antioxidant Action of Vitamin-C


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOX5

    1 Interacting protein for NOX5 (Q96PH12) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P621572MINT-4652029 MINT-4652013 MINT-4652046
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS11483596
    GO:0001525angiogenesis IEA--
    GO:0001935endothelial cell proliferation IDA17275676
    GO:0006915apoptotic process NAS11483596
    GO:0008283cell proliferation NAS11483596

    NOX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOX5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOX5

    5 HMDB Compounds for NOX5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    2 Novoseek inferred chemical compound relationships for NOX5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 66.3 13 14982937 (4), 17346712 (2), 11483596 (2), 18160052 (1) (see all 5)
    superoxide 49.8 6 17346712 (2), 14982937 (2), 18160052 (1), 11483596 (1)

    Search CenterWatch for drugs/clinical trials and news about NOX5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOX5 gene (3 alternative transcripts): 
    NM_001184779.1  NM_001184780.1  NM_024505.3  

    Unigene Cluster for NOX5:

    NADPH oxidase, EF-hand calcium binding domain 5
    Hs.657932  [show with all ESTs]
    Unigene Representative Sequence: NR_033671
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448182 ENST00000260364(uc002arq.2 uc002arp.2 uc010bid.2)
    ENST00000455873 ENST00000388866(uc002arr.2 uc002ars.2 uc010bif.2)
    ENST00000530406 ENST00000527315(uc010bie.2) ENST00000525143 ENST00000525163
    ENST00000529367
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOX5
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NOX5:
    hsa-miR-485-5p hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidNOX5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NOX5
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX5
    Sirion Biotech Customized lentivirus for stable overexpression of NOX5 
                         Customized lentivirus expression plasmids for stable overexpression of NOX5 
    Primer
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    OriGene qPCR primer pairs and template standards for NOX5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOX5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOX5

    Additional mRNA sequence: 

    AF275321.1 AF317889.1 AF325189.1 AF325190.1 AF353088.1 AF353089.1 AK026011.1 AK074058.1 
    AK314689.1 AY166601.1 AY358983.1 BC017998.1 BC125097.1 BC125098.1 DQ413001.1 NR_033671.2 
    NR_033672.1 

    10 DOTS entries:

    DT.452299  DT.99947465  DT.97838444  DT.97838445  DT.100682814  DT.97838442  DT.65288255  DT.100759159 
    DT.121049990  DT.75185674 

    24/94 AceView cDNA sequences (see all 94):

    BC017998 AW340601 AY166601 AY358983 BU625703 H52859 AF353088 NM_024505 
    CR610432 BI826643 BF434176 BQ215955 CD107927 AF325189 AF325190 AI797949 
    BM929516 BE045942 AF353089 AI990773 BM564110 NM_145658 BQ013471 AI652853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NOX5 Expression
    About this image


    Genevestigator expression for NOX5

    SOURCE GeneReport for Unigene cluster: Hs.657932

    UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
    Tissue specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen
    and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary,
    placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and
    isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed
    in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth
    muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOX5: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOX5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NOX5 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia NOX51 NADPH oxidase, EF-hand calcium binding domain 5 86.32(n)
    85.26(a)
      487620  NM_001103218.1  NP_001096688.1 
    chicken
    (Gallus gallus)
    Aves NOX51 NADPH oxidase, EF-hand calcium binding domain 5 69.96(n)
    63.56(a)
      415565  NM_001100285.1  NP_001093755.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOX56
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343330.1(812535-836179)
    zebrafish
    (Danio rerio)
    Actinopterygii nox51 NADPH oxidase, EF-hand calcium binding domain 5 69.23(n)
    68.85(a)
      100149800  XM_001921859.1  XP_001921894.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38963
    Nox1
    NADPH oxidase1 41(a)3
    56.43(n)1
    49.71(a)1
      53B23
    57403101  NM_001103866.11  NP_001097336.11 


    ENSEMBL Gene Tree for NOX5 (if available)
    TreeFam Gene Tree for NOX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOX5 gene
    CYBB2  NOX12  NOX32  NOX42  DUOX22  DUOX12  

    NOX5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2432 SNPs in NOX5 are shown (see all 2432)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs560201131,2
    C--46147812(+) TATCT-/GGGAGA 5 -- int12Minor allele frequency- G:0.00NA CSA 4
    rs1444166801,2
    --49272673(+) GCCCAA/GAGTAA 3 -- us2k10--------
    rs2007055651,2
    C--49272688(+) CAGCA-/AGAGTTA 3 -- us2k10--------
    rs1479798671,2
    --49272706(+) AAAGCA/GAAAGA 3 -- us2k10--------
    rs1416500741,2
    --49272720(+) AACCTG/TCCACA 3 -- us2k10--------
    rs1506883001,2
    C--49272726(+) CCACAC/TGACAG 3 -- us2k10--------
    rs1410481181,2
    --49272727(+) CACACC/GACAGA 3 -- us2k10--------
    rs118576751,2
    C,F,H--49272740(+) gagacT/Cccata 3 -- us2k120Minor allele frequency- C:0.18NS EA NA WA CSA 2343
    rs1447948831,2
    --49272773(+) CAGCCC/TGCTTT 3 -- us2k10--------
    rs1853212561,2
    --49272794(+) TCTGGA/CCCCAC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NOX5 (69222839 - 69355083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NOX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669530CNV Deletion23128226
    nsv1584CNV Loss18451855
    nsv521203CNV Loss19592680
    esv33141CNV Gain17666407
    esv33369CNV Gain17666407
    esv33333CNV Gain17666407
    esv275002CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606572    OMIM disorders: --

    17 diseases for NOX5:    About MalaCards
    esophageal adenocarcinoma    chronic granulomatous disease    hairy cell leukemia    gastroesophageal reflux disease
    hiv/aids    barrett's esophagus    t-cell leukemia    acute myocardial infarction
    myocardial infarction    endotheliitis    esophagitis    adenocarcinoma
    leukemia    prostate cancer    prostatitis    neuronitis
    breast cancer


    NOX5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NOX5
    Human Genome Epidemiology (HuGE) Navigator: NOX5 (2 documents)

    Export disorders for NOX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOX5 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with NOX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. (PubMed id 11483596)1, 2, 3, 9 Banfi B....Krause K.-H. (2001)
    2. Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). (PubMed id 14982937)1, 2, 9 Banfi B.... Cox J.A. (2004)
    3. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    4. NOX5 variants are functionally active in endothelial cells. (PubMed id 17275676)1, 2 BelAiba R.S.... Gorlach A. (2007)
    5. Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. (PubMed id 16339585)1, 2 Kamiguti A.S.... Zuzel M. (2005)
    6. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. (PubMed id 16179589)1, 2 Cucoranu I.... Sorescu D. (2005)
    7. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. (PubMed id 15994299)1, 2 Kawahara T.... Lambeth J.D. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. (PubMed id 11376945)1, 2 Cheng G.... Lambeth J.D. (2001)
    10. NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. (PubMed id 17346712)1, 9 Tirone F. and Cox J.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79400 HGNC: 14874 AceView: NOX5 Ensembl:ENSG00000255346 euGenes: HUgn79400
    ECgene: NOX5 H-InvDB: NOX5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOX5 gene:
    Search GeneIP for patents involving NOX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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