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NOX5 Gene

protein-coding   GIFtS: 48
GCID: GC15P069222

NADPH Oxidase, EF-Hand Calcium Binding Domain 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADPH Oxidase, EF-Hand Calcium Binding Domain 51 2
NADPH Oxidase 52
EC 1.6.3.-3

External Ids:    HGNC: 148741   Entrez Gene: 794002   Ensembl: ENSG000002553467   OMIM: 6065725   UniProtKB: Q96PH13   

Export aliases for NOX5 gene to outside databases

Previous GC identifers: GC15P065065 GC15P062322 GC15P066801 GC15P066939 GC15P066940 GC15P067009 GC15P046055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOX5 Gene:
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes
a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel
that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for NOX5 Gene:
NOX5 (NADPH oxidase, EF-hand calcium binding domain 5) is a protein-coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and calcium ion binding. An important paralog of this gene is CYBB.

UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
Function: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton
channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth
and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS),
proliferation and angiogenesis and contribute to endothelial response to thrombin

Gene Wiki entry for NOX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOX5 gene promoter:
         RFX1   MIF-1   HNF-4alpha2   Evi-1   HNF-4alpha1   POU2F1   POU2F1b   POU2F1a   HOXA5   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOX5 promoter sequence
   Search Chromatin IP Primers for NOX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.31

NOX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P069222:  view genomic region     (about GC identifiers)

Start:
69,222,839 bp from pter      End:
69,355,083 bp from pter
Size:
132,245 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1 (See protein sequence)
Recommended Name: NADPH oxidase 5  
Size: 765 amino acids; 86439 Da
Cofactor: FAD
Cofactor: Magnesium
Developmental stage: Expressed in fetal tissues
Sequence caution: Sequence=AAG33638.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15319.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB84897.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RBJ4 Q08AN2 Q08AN3 Q8TEQ1 Q8TER4 Q96PH2 Q96PJ8 Q96PJ9 Q9H6E0 Q9HAM8
Alternative splicing: 6 isoforms:  Q96PH1-1   Q96PH1-3   Q96PH1-4   Q96PH1-2   Q96PH1-5   Q96PH1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOX5: NX_Q96PH1

Explore proteomics data for NOX5 at MOPED


See NOX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001171708.1  NP_001171709.1  NP_078781.3  

ENSEMBL proteins: 
 ENSP00000410887   ENSP00000454143   ENSP00000416828   ENSP00000373518   ENSP00000432440  
 ENSP00000455703  

NOX5 Human Recombinant Protein Products:

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Novus Biologicals NOX5 Lysate
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Cloud-Clone Corp. Proteins for NOX5

 
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antibodies-online peptides for NOX5

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antibodies-online antibodies for NOX5 (46 products) 

NOX5 Assay Products:

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antibodies-online kits for NOX5 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
EFHAND: EF-hand domain containing

Selected InterPro protein domains (see all 8):
 IPR017927 Fd_Rdtase_FAD-bd
 IPR018247 EF_Hand_1_Ca_BS
 IPR011992 EF-hand-dom_pair
 IPR002048 EF_hand_dom
 IPR013130 Fe3_Rdtase_TM_dom

Graphical View of Domain Structure for InterPro Entry Q96PH1

ProtoNet protein and cluster: Q96PH1

1 Blocks protein domain: IPB013130 Ferric reductase-like transmembrane component

UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
Domain: Isoform v1 and isoform v2 of this protein have four functional EF-hand calcium-binding domains. Isoform v3
and isoform v4 have the third EF-hand domain interrupted by an insert
Similarity: Contains 4 EF-hand domains
Similarity: Contains 1 FAD-binding FR-type domain
Similarity: Contains 1 ferric oxidoreductase domain


Find genes that share domains with NOX5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NOX5_HUMAN, Q96PH1
Function: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton
channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth
and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS),
proliferation and angiogenesis and contribute to endothelial response to thrombin
Enzyme regulation: Activated by calcium which induces conformational changes and interaction between the
N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium
Biophysicochemical properties: Kinetic parameters: KM=1.06 uM for calcium;
Induction: Down-regulated by TGFB1

     Enzyme Number (IUBMB): EC 1.6.3.-1

     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005509calcium ion binding IEA--
GO:0005515protein binding IPI17346712
GO:0015252hydrogen ion channel activity IDA11483596
GO:0016175superoxide-generating NADPH oxidase activity IDA11483596
GO:0016491oxidoreductase activity ----
     
Find genes that share ontologies with NOX5           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for NOX5:
 G0/1 arrest  Increased G1 DNA content 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NOX5

miRNA
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Block miRNA regulation of human, mouse, rat NOX5 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate NOX5:
hsa-miR-485-5p hsa-miR-765
SwitchGear 3'UTR luciferase reporter plasmidNOX5 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NOX5
Predesigned siRNA for gene silencing in human, mouse, rat NOX5

Gene Editing
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DNA2.0 Custom Protein Engineering Service for NOX5

Clone
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OriGene clones in human, mouse for NOX5 (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): NOX5 (NM_024505)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX5

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX5


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NOX5_HUMAN, Q96PH1: Membrane; Multi-pass membrane protein (Potential)
NOX5_HUMAN, Q96PH1: Isoform v2: Endoplasmic reticulum
NOX5_HUMAN, Q96PH1: Isoform v5: Endoplasmic reticulum
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
peroxisome2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with NOX5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NOX5 About    
See pathways by source

SuperPathContained pathways About
1Apoptotic Pathways in Synovial Fibroblasts
Rac1 Pathway0.65
2PAK Pathway
Antioxidant Action of Vitamin-C0.56

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOX5
    Rac1 Pathway
Antioxidant Action of Vitamin-C


    Pathway & Disease-focused RT2 Profiler PCR Arrays including NOX5: 
          Oxidative Stress in human mouse rat
          Nitric Oxide Signaling Pathway in human mouse rat
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for NOX5

2 Interacting proteins for NOX5 (Q96PH11, 2) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CALMP621571, 2EBI-7305642,EBI-397403 MINT-4652029 MINT-4652013 MINT-4652046
--P621571, 2EBI-7305642,EBI-397403 MINT-4652029 MINT-4652013 MINT-4652046
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Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000910cytokinesis NAS11483596
GO:0001525angiogenesis IEA--
GO:0001935endothelial cell proliferation IDA17275676
GO:0006915apoptotic process NAS11483596
GO:0008283cell proliferation NAS11483596

Find genes that share ontologies with NOX5           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NOX5

5 HMDB Compounds for NOX5    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
Heme(protoporphyrinato)iron (see all 19)14875-96-8--
MagnesiumMagnesium (see all 2)7439-95-4--
NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

2 Novoseek inferred chemical compound relationships for NOX5 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadph 66.3 13 14982937 (4), 17346712 (2), 11483596 (2), 18160052 (1) (see all 5)
superoxide 49.8 6 17346712 (2), 14982937 (2), 18160052 (1), 11483596 (1)



Find genes that share compounds with NOX5           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NOX5 gene (3 alternative transcripts): 
NM_001184779.1  NM_001184780.1  NM_024505.3  

Unigene Cluster for NOX5:

NADPH oxidase, EF-hand calcium binding domain 5
Hs.657932  [show with all ESTs]
Unigene Representative Sequence: NR_033671
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000448182 ENST00000260364(uc002arq.2 uc002arp.2 uc010bid.2)
ENST00000455873 ENST00000388866(uc002arr.2 uc002ars.2 uc010bif.2)
ENST00000530406 ENST00000527315(uc010bie.2) ENST00000525143 ENST00000525163
ENST00000529367
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NOX5 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate NOX5:
hsa-miR-485-5p hsa-miR-765
SwitchGear 3'UTR luciferase reporter plasmidNOX5 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NOX5
Predesigned siRNA for gene silencing in human, mouse, rat NOX5
Clone
Products:
     
OriGene clones in human, mouse for NOX5 (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): NOX5 (NM_024505)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX5
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX5
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NOX5
OriGene qSTAR qPCR primer pairs in human, mouse for NOX5
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NOX5
  QuantiTect SYBR Green Assays in human, mouse, rat NOX5
  QuantiFast Probe-based Assays in human, mouse, rat NOX5

Additional mRNA sequence: 

AF275321.1 AF317889.1 AF325189.1 AF325190.1 AF353088.1 AF353089.1 AK026011.1 AK074058.1 
AK314689.1 AY166601.1 AY358983.1 BC017998.1 BC125097.1 BC125098.1 DQ413001.1 NR_033671.2 
NR_033672.1 

10 DOTS entries:

DT.452299  DT.99947465  DT.97838444  DT.97838445  DT.100682814  DT.97838442  DT.65288255  DT.100759159 
DT.121049990  DT.75185674 

Selected AceView cDNA sequences (see all 94):

BM929516 H52859 AF353089 AW340601 AI797949 BE045942 NM_024505 AF325190 
AF353088 BQ013471 BC017998 AI652853 BM564110 BQ215955 AY166601 AF325189 
BI826643 BU625703 AY358983 CR610432 AI990773 CD107927 BF434176 NM_145658 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NOX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NOX5 Expression
About this image

NOX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NOX5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.657932

UniProtKB/Swiss-Prot: NOX5_HUMAN, Q96PH1
Tissue specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen
and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary,
placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and
isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed
in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth
muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level)

    Pathway & Disease-focused RT2 Profiler PCR Arrays including NOX5: 
          Oxidative Stress in human mouse rat
          Nitric Oxide Signaling Pathway in human mouse rat
          Apoptosis 384HT in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for NOX5
OriGene qSTAR qPCR primer pairs in human, mouse for NOX5
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NOX5
QuantiTect SYBR Green Assays in human, mouse, rat NOX5
QuantiFast Probe-based Assays in human, mouse, rat NOX5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NOX5 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia NOX51 NADPH oxidase, EF-hand calcium binding domain 5 86.32(n)
85.26(a)
  487620  NM_001103218.1  NP_001096688.1 
chicken
(Gallus gallus)
Aves NOX51 NADPH oxidase, EF-hand calcium binding domain 5 69.84(n)
63.78(a)
  415565  NM_001100285.1  NP_001093755.1 
lizard
(Anolis carolinensis)
Reptilia NOX56
NADPH oxidase, EF-hand calcium binding domain 5
57(a)
1 ↔ 1
GL343330.1(812535-836179)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nox51 NADPH oxidase, EF-hand calcium binding domain 5 68.15(n)
68.71(a)
  100491600  XM_002932959.2  XP_002933005.2 
zebrafish
(Danio rerio)
Actinopterygii nox51 NADPH oxidase, EF-hand calcium binding domain 5 69.13(n)
68.58(a)
  100149800  XM_001921859.2  XP_001921894.1 
fruit fly
(Drosophila melanogaster)
Insecta CG38963
Nox1
NADPH oxidase1 41(a)3
56.89(n)1
50.07(a)1
  53B23
57403101  NM_001103866.11  NP_001097336.11 


ENSEMBL Gene Tree for NOX5 (if available)
TreeFam Gene Tree for NOX5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NOX5 gene
CYBB2  NOX12  NOX32  NOX42  DUOX22  DUOX12  

Find genes that share paralogs with NOX5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NOX5 (see all 2432)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs560201131,2
C--46147812(+) TATCT-/GGGAGA 5 -- int12Minor allele frequency- G:0.00NA CSA 4
rs1444166801,2
--49272673(+) GCCCAA/GAGTAA 3 -- us2k10--------
rs2007055651,2
C--49272688(+) CAGCA-/AGAGTTA 3 -- us2k10--------
rs1479798671,2
--49272706(+) AAAGCA/GAAAGA 3 -- us2k10--------
rs1416500741,2
--49272720(+) AACCTG/TCCACA 3 -- us2k10--------
rs1506883001,2
C--49272726(+) CCACAC/TGACAG 3 -- us2k10--------
rs1410481181,2
--49272727(+) CACACC/GACAGA 3 -- us2k10--------
rs118576751,2
C,F,H--49272740(+) gagacT/Cccata 3 -- us2k120Minor allele frequency- C:0.18NS EA NA WA CSA 2343
rs1447948831,2
--49272773(+) CAGCCC/TGCTTT 3 -- us2k10--------
rs1853212561,2
--49272794(+) TCTGGA/CCCCAC 3 -- us2k10--------

HapMap Linkage Disequilibrium report for NOX5 (69222839 - 69355083 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for NOX5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669530CNV Deletion23128226
nsv1584CNV Loss18451855
nsv521203CNV Loss19592680
esv33141CNV Gain17666407
esv33369CNV Gain17666407
esv33333CNV Gain17666407
esv275002CNV Gain+Loss21479260

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606572    OMIM disorders: --


Find genes that share disorders with NOX5           About GenesLikeMe

Genetic Association Database (GAD): NOX5
Human Genome Epidemiology (HuGE) Navigator: NOX5 (2 documents)

Export disorders for NOX5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NOX5 gene, integrated from 10 sources (see all 56):
(articles sorted by number of sources associating them with NOX5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. (PubMed id 11483596)1, 2, 3, 9 Banfi B....Krause K.-H. (J. Biol. Chem. 2001)
  2. Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). (PubMed id 14982937)1, 2, 9 Banfi B.... Cox J.A. (J. Biol. Chem. 2004)
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
  4. NOX5 variants are functionally active in endothelial cells. (PubMed id 17275676)1, 2 BelAiba R.S.... Gorlach A. (Free Radic. Biol. Med. 2007)
  5. Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. (PubMed id 16339585)1, 2 Kamiguti A.S.... Zuzel M. (J. Immunol. 2005)
  6. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. (PubMed id 16179589)1, 2 Cucoranu I.... Sorescu D. (Circ. Res. 2005)
  7. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. (PubMed id 15994299)1, 2 Kawahara T.... Lambeth J.D. (J. Biol. Chem. 2005)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. (PubMed id 11376945)1, 2 Cheng G.... Lambeth J.D. (Gene 2001)
  10. NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. (PubMed id 17346712)1, 9 Tirone F. and Cox J.A. (FEBS Lett. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79400 HGNC: 14874 AceView: NOX5 Ensembl:ENSG00000255346 euGenes: HUgn79400
ECgene: NOX5 H-InvDB: NOX5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NOX5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NOX5 gene:
Search GeneIP for patents involving NOX5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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