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Aliases for NOX3 Gene

Aliases for NOX3 Gene

  • NADPH Oxidase 3 2 3
  • Mitogenic Oxidase 2 3 4
  • Gp91phox Homolog 3 3 4
  • GP91-3 3 4
  • MOX-2 3 4
  • NADPH Oxidase Catalytic Subunit-Like 3 3
  • EC 1.6.3.- 4
  • EC 1.6.3 63
  • MOX2 4

External Ids for NOX3 Gene

Previous GeneCards Identifiers for NOX3 Gene

  • GC06M155277
  • GC06M155611
  • GC06M155747
  • GC06M155808
  • GC06M153278
  • GC06M155716

Summaries for NOX3 Gene

Entrez Gene Summary for NOX3 Gene

  • This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]

GeneCards Summary for NOX3 Gene

NOX3 (NADPH Oxidase 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include oxidoreductase activity and superoxide-generating NADPH oxidase activity. An important paralog of this gene is NOX5.

UniProtKB/Swiss-Prot for NOX3 Gene

  • NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.

Gene Wiki entry for NOX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOX3 Gene

Genomics for NOX3 Gene

Regulatory Elements for NOX3 Gene

Genomic Location for NOX3 Gene

Chromosome:
6
Start:
155,395,368 bp from pter
End:
155,455,903 bp from pter
Size:
60,536 bases
Orientation:
Minus strand

Genomic View for NOX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOX3 Gene

Proteins for NOX3 Gene

  • Protein details for NOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY0-NOX3_HUMAN
    Recommended name:
    NADPH oxidase 3
    Protein Accession:
    Q9HBY0
    Secondary Accessions:
    • Q9HBJ9

    Protein attributes for NOX3 Gene

    Size:
    568 amino acids
    Molecular mass:
    64935 Da
    Quaternary structure:
    • Interacts with and stabilizes CYBA/p22phox.

neXtProt entry for NOX3 Gene

Proteomics data for NOX3 Gene at MOPED

Selected DME Specific Peptides for NOX3 Gene

Post-translational modifications for NOX3 Gene

  • Glycosylation at Asn 163 and Asn 238
  • Modification sites at PhosphoSitePlus

Other Protein References for NOX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for NOX3 Gene

Suggested Antigen Peptide Sequences for NOX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBY0

UniProtKB/Swiss-Prot:

NOX3_HUMAN :
  • Contains 1 FAD-binding FR-type domain.
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 ferric oxidoreductase domain.
genes like me logo Genes that share domains with NOX3: view

No data available for Gene Families for NOX3 Gene

Function for NOX3 Gene

Molecular function for NOX3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride.
UniProtKB/Swiss-Prot Function:
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.

Enzyme Numbers (IUBMB) for NOX3 Gene

Gene Ontology (GO) - Molecular Function for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016175 superoxide-generating NADPH oxidase activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with NOX3: view
genes like me logo Genes that share phenotypes with NOX3: view

Animal Model Products

miRNA for NOX3 Gene

miRTarBase miRNAs that target NOX3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOX3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NOX3 Gene

Localization for NOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOX3 Gene COMPARTMENTS Subcellular localization image for NOX3 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0043020 NADPH oxidase complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NOX3: view

Pathways & Interactions for NOX3 Gene

genes like me logo Genes that share pathways with NOX3: view

Interacting Proteins for NOX3 Gene

Gene Ontology (GO) - Biological Process for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0009590 detection of gravity IEA --
GO:0009629 response to gravity --
GO:0042554 superoxide anion generation IEA --
genes like me logo Genes that share ontologies with NOX3: view

No data available for SIGNOR curated interactions for NOX3 Gene

Drugs & Compounds for NOX3 Gene

(1) Drugs for NOX3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(2) Additional Compounds for NOX3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with NOX3: view

Transcripts for NOX3 Gene

mRNA/cDNA for NOX3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOX3 Gene

NADPH oxidase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOX3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOX3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2:

Relevant External Links for NOX3 Gene

GeneLoc Exon Structure for
NOX3
ECgene alternative splicing isoforms for
NOX3

Expression for NOX3 Gene

mRNA expression in normal human tissues for NOX3 Gene

mRNA differential expression in normal tissues according to GTEx for NOX3 Gene

This gene is overexpressed in Brain - Hippocampus (x10.7), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Frontal Cortex (BA9) (x4.9).

Protein differential expression in normal tissues from HIPED for NOX3 Gene

This gene is overexpressed in Adipocyte (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOX3 Gene



SOURCE GeneReport for Unigene cluster for NOX3 Gene Hs.247776

genes like me logo Genes that share expression patterns with NOX3: view

Protein tissue co-expression partners for NOX3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NOX3 Gene

Orthologs for NOX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOX3 35
  • 86.1 (n)
  • 84.1 (a)
NOX3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOX3 35
  • 86.71 (n)
  • 87.13 (a)
NOX3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nox3 35
  • 80.93 (n)
  • 80.63 (a)
Nox3 16
Nox3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOX3 35
  • 99.06 (n)
  • 98.94 (a)
NOX3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nox3 35
  • 81.28 (n)
  • 81.34 (a)
oppossum
(Monodelphis domestica)
Mammalia NOX3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOX3 35
  • 73.37 (n)
  • 73.19 (a)
NOX3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOX3 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01082570.1 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for NOX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOX3 Gene

ENSEMBL:
Gene Tree for NOX3 (if available)
TreeFam:
Gene Tree for NOX3 (if available)

Paralogs for NOX3 Gene

Paralogs for NOX3 Gene

(5) SIMAP similar genes for NOX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NOX3: view

Variants for NOX3 Gene

Sequence variations from dbSNP and Humsavar for NOX3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs151223 -- 155,395,735(+) GAGGA(A/C)TACTT intron-variant
rs162997 -- 155,397,585(+) atctg(C/T)gtggt intron-variant
rs162998 -- 155,397,943(+) TAGTG(A/G)CTATC intron-variant
rs162999 -- 155,398,400(+) CTATA(G/T)AGCCT intron-variant
rs163000 -- 155,399,107(+) CAGGC(A/G)AGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOX3 Gene

Variant ID Type Subtype PubMed ID
nsv886791 CNV Gain 21882294
nsv886792 CNV Loss 21882294
esv33329 CNV Loss 17666407
nsv525807 CNV Loss 19592680
nsv5553 CNV Loss 18451855

Variation tolerance for NOX3 Gene

Residual Variation Intolerance Score: 40.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.54; 92.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOX3 Gene

HapMap Linkage Disequilibrium report
NOX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOX3 Gene

Disorders for NOX3 Gene

Relevant External Links for NOX3

Genetic Association Database (GAD)
NOX3
Human Genome Epidemiology (HuGE) Navigator
NOX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOX3
genes like me logo Genes that share disorders with NOX3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOX3 Gene

Publications for NOX3 Gene

  1. The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases. (PMID: 19534724) Miyano K. … Sumimoto H. (Biochem. J. 2009) 23 67
  2. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. (PMID: 17140397) Nakano Y. … Nauseef W.M. (Biochem. J. 2007) 23 67
  3. Role of the small GTPase Rac in p22phox-dependent NADPH oxidases. (PMID: 17583407) Miyano K. … Sumimoto H. (Biochimie 2007) 23 67
  4. Involvement of Rac1 in activation of multicomponent Nox1- and Nox3- based NADPH oxidases. (PMID: 16507994) Ueyama T. … Leto T.L. (Mol. Cell. Biol. 2006) 23 67
  5. Localizing NADPH oxidase-derived ROS. (PMID: 16926363) Ushio-Fukai M. (Sci. STKE 2006) 23 67

Products for NOX3 Gene

Sources for NOX3 Gene

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