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NOX3 Gene

protein-coding   GIFtS: 57
GCID: GC06M155716

NADPH Oxidase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADPH Oxidase 31 2     NADPH Oxidase Catalytic Subunit-Like 32
Mitogenic Oxidase 22 3     EC 1.6.3.-3
GP91-32 3     MOX23
MOX-22 3     EC 1.6.38
Gp91phox Homolog 32 3     

External Ids:    HGNC: 78901   Entrez Gene: 505082   Ensembl: ENSG000000747717   OMIM: 6071055   UniProtKB: Q9HBY03   

Export aliases for NOX3 gene to outside databases

Previous GC identifers: GC06M155277 GC06M155611 GC06M155747 GC06M155808 GC06M153278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOX3 Gene:
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate
superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS
generated by family members have been implicated in numerous biological functions including host defense,
posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell
differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in
the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception
of gravity.(provided by RefSeq, May 2009)

GeneCards Summary for NOX3 Gene:
NOX3 (NADPH oxidase 3) is a protein-coding gene. Diseases associated with NOX3 include hiv/aids, and rabies. GO annotations related to this gene include superoxide-generating NADPH oxidase activity. An important paralog of this gene is CYBB.

UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0
Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox.
Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in
the perception of gravity

Gene Wiki entry for NOX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOX3 gene promoter:
         Oct-B1   TBP   oct-B3   oct-B2   POU2F2   RORalpha1   POU2F1   POU2F1a   TFIID   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOX3 promoter sequence
   Search Chromatin IP Primers for NOX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

NOX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M155716:  view genomic region     (about GC identifiers)

Start:
155,716,502 bp from pter      End:
155,777,037 bp from pter
Size:
60,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0 (See protein sequence)
Recommended Name: NADPH oxidase 3  
Size: 568 amino acids; 64935 Da
Subunit: Interacts with and stabilizes CYBA/p22phox
Developmental stage: Expressed in fetal kidney and to a lower extent in liver, lung and spleen
Secondary accessions: Q9HBJ9

Explore the universe of human proteins at neXtProt for NOX3: NX_Q9HBY0

Explore proteomics data for NOX3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn163, Asn238
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NOX3 (Q9HBY0) (see all 5)
     GIGVTPF  AFEWFADLL  CLNFNCMLIL  ARASALCLNFN 


    See NOX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056533.1  
    ENSEMBL proteins: 
     ENSP00000159060  

    NOX3 Human Recombinant Protein Products:

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    Novus Biologicals NOX3 Protein
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    Cloud-Clone Corp. Proteins for NOX3

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    Cloud-Clone Corp. CLIAs for NOX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR000778 Cyt_b245_heavy_chain
     IPR013130 Fe3_Rdtase_TM_dom
     IPR013121 Fe_red_NAD-bd_6
     IPR013112 FAD-bd_8

    Graphical View of Domain Structure for InterPro Entry Q9HBY0

    ProtoNet protein and cluster: Q9HBY0

    2 Blocks protein domains:
    IPB000778 Cytochrome B-245 heavy chain signature
    IPB013130 Ferric reductase-like transmembrane component


    UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 ferric oxidoreductase domain


    NOX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOX3_HUMAN, Q9HBY0
    Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox.
    Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in
    the perception of gravity
    Enzyme regulation: Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively
    activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by
    diphenyleneiodonium chloride

         Enzyme Numbers (IUBMB): EC 1.6.32 EC 1.6.3.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016175superoxide-generating NADPH oxidase activity IEA--
    GO:0016491oxidoreductase activity ----
         
    NOX3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOX3:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Nox3):
     adipose tissue  behavior/neurological  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 

    NOX3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOX3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOX3:
    hsa-mir-26b-5p (MIRT029921)

    Block miRNA regulation of human, mouse, rat NOX3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOX3:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNOX3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NOX3
    Predesigned siRNA for gene silencing in human, mouse, rat NOX3

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOX3 (NM_015718)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX3

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOX3_HUMAN, Q9HBY0: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043020NADPH oxidase complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    NOX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOX3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Phagosome
    Phagosome
    5Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOX3
        Rac1 Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes


    4 Kegg Pathways  (Kegg details for NOX3):
        HIF-1 signaling pathway
    Phagosome
    Osteoclast differentiation
    Leukocyte transendothelial migration


    NOX3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOX3
    Interactions:

        GeneGlobe Interaction Network for NOX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for NOX3 (ENSP000001590604) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK11ENSP000003336854STRING: ENSP00000333685
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MMP9ENSP000003614054STRING: ENSP00000361405
    VCAM1ENSP000002947284STRING: ENSP00000294728
    MAPK12ENSP000002156594STRING: ENSP00000215659
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0009590detection of gravity IEA--
    GO:0009629response to gravity ----
    GO:0042554superoxide anion generation IEA--
    GO:0048840otolith development IEA--

    NOX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOX3

    3 HMDB Compounds for NOX3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 Novoseek inferred chemical compound relationship for NOX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 59.3 3 17140397 (1), 19534724 (1), 17583407 (1)



    NOX3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOX3 gene: 
    NM_015718.2  

    Unigene Cluster for NOX3:

    NADPH oxidase 3
    Hs.247776  [show with all ESTs]
    Unigene Representative Sequence: AF190122
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000159060(uc003qqm.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat NOX3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOX3:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNOX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOX3
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    GenScript: all cDNA clones in your preferred vector: NOX3 (NM_015718)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOX3
      QuantiTect SYBR Green Assays in human, mouse, rat NOX3
      QuantiFast Probe-based Assays in human, mouse, rat NOX3

    Additional mRNA sequence: 

    AF190122.1 AF229177.1 

    1 DOTS entry:

    DT.91995284 

    3 AceView cDNA sequences:

    AF190122 NM_015718 AF229177 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NOX3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                              -     -     -                           
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for NOX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATATACAA
    NOX3 Expression
    About this image

    NOX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247776
        Custom PCR Arrays for NOX3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NOX3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nox31 , 5 NADPH oxidase 31, 5 80.93(n)1
    80.63(a)1
      17 (2.05 cM)5
    2244801  NM_198958.21  NP_945196.21 
     36352405 
    chicken
    (Gallus gallus)
    Aves NOX31 NADPH oxidase 3 73.37(n)
    73.19(a)
      428609  XM_004935646.1  XP_004935703.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOX36
    NADPH oxidase 3
    69(a)
    1 ↔ 1
    1(214512350-214554095)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01082570.16
    Uncharacterized protein
    33(a)
    many ↔ many
    15(42667695-42674013) ENSDARG00000086102


    ENSEMBL Gene Tree for NOX3 (if available)
    TreeFam Gene Tree for NOX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOX3 gene
    CYBB2  NOX12  NOX42  DUOX22  DUOX12  NOX52  
    5 SIMAP similar genes for NOX3 using alignment to 1 protein entry:     NOX3_HUMAN:
    CYBB    NOX1    DUOX2    NOX4    DUOX1

    NOX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOX3 (see all 1488)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2319411,2
    C--153298070(+) TTCTTC/TCTTTT 1 -- int1 trp30--------
    rs1898583121,2
    --153319008(+) TTTTTA/TAAACA 1 -- int10--------
    rs679751841,2
    C--153329371(+) TATAT-/A/AT  
            
    TTATA
    1 -- int11NA 2
    rs1886271101,2
    --155715197(+) AAAAGC/TAATAA 1 -- ds50010--------
    rs1408264661,2
    --155715246(+) TATCCA/TGCTAA 1 -- ds50010--------
    rs1923417121,2
    --155715297(+) AGCCTC/GAATTA 1 -- ds50010--------
    rs1163933261,2
    F--155715308(+) AACTTA/TAATGG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1845549321,2
    --155715414(+) GCAGAC/GATAGT 1 -- ds50010--------
    rs1447622661,2
    --155715632(+) ACAGTA/CCACAA 1 -- ds50010--------
    rs796728571,2
    --155715696(+) GTTCTG/TTTGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NOX3 (155716502 - 155777037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NOX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886792CNV Loss21882294
    nsv5553CNV Loss18451855
    esv33329CNV Loss17666407
    nsv525807CNV Loss19592680
    nsv886791CNV Gain21882294

    Locus Specific Mutation Databases (LSDB): NOX3

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOX3
    DNA2.0 Custom Variant and Variant Library Synthesis for NOX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607105    OMIM disorders: --

    15 diseases for NOX3:    
    About MalaCards
    hiv/aids    rabies    dementia    insulin resistance
    asthma    lymphoblastic leukemia    inflammatory bowel disease    pancreatic cancer
    hiv-1    endotheliitis    hepatitis    pancreatitis
    leukemia    breast cancer    neuronitis


    NOX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NOX3
    Human Genome Epidemiology (HuGE) Navigator: NOX3 (6 documents)

    Export disorders for NOX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOX3 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with NOX3)
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    1. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. (PubMed id 11376945)1, 2, 3 Cheng G.... Lambeth J.D. (Gene 2001)
    2. Nox3 regulation by NOXO1, p47phox, and p67phox. (PubMed id 15181005)1, 2, 9 Cheng G.... Lambeth J.D. (J. Biol. Chem. 2004)
    3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (PLoS ONE 2008)
    6. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. (PubMed id 15824103)1, 2 Ueno N.... Sumimoto H. (J. Biol. Chem. 2005)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells. (PubMed id 10974555)1, 2 Kikuchi H.... Fukumoto M. (Gene 2000)
    9. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. (PubMed id 17140397)1, 9 Nakano Y....Nauseef W.M. (Biochem. J. 2007)
    10. Involvement of Rac1 in activation of multicomponent Nox1- and Nox3- based NADPH oxidases. (PubMed id 16507994)1, 9 Ueyama T.... Leto T.L. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50508 HGNC: 7890 AceView: NOX3 Ensembl:ENSG00000074771 euGenes: HUgn50508
    ECgene: NOX3 Kegg: 50508 H-InvDB: NOX3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOX3 gene:
    Search GeneIP for patents involving NOX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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