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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOX3 Gene

protein-coding   GIFtS: 55
GCID: GC06M155716

NADPH oxidase 3

 Explore 5 diseases affiliated with
NOX3 via our new
 Human Malady Compendium 
Biological research products
for NOX3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NADPH Oxidase 31 2     NADPH Oxidase Catalytic Subunit-Like 32
GP91-31 2 3     EC 1.6.3.-3
Mitogenic Oxidase 22 3     MOX23
MOX-22 3     EC 1.6.38
Gp91phox Homolog 32 3     

External Ids:    HGNC: 78901   Entrez Gene: 505082   Ensembl: ENSG000000747717   OMIM: 6071055   UniProtKB: Q9HBY03   

Export aliases for NOX3 gene to outside databases

Previous GC identifers: GC06M155277 GC06M155611 GC06M155747 GC06M155808 GC06M153278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOX3:
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide
and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by
family members have been implicated in numerous biological functions including host defense, posttranlational
processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein
encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of
otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.(provided by
RefSeq, May 2009)

UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0
Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a
role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the
perception of gravity

Gene Wiki entry for NOX3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOX3 gene promoter:
         Oct-B1   TBP   oct-B3   oct-B2   POU2F2   RORalpha1   POU2F1   POU2F1a   TFIID   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

NOX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M155716:  view genomic region     (about GC identifiers)

Start:
155,716,502 bp from pter      End:
155,777,037 bp from pter
Size:
60,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0 (See protein sequence)
Recommended Name: NADPH oxidase 3  
Size: 568 amino acids; 64935 Da
Subunit: Interacts with and stabilizes CYBA/p22phox
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed in fetal kidney and to a lower extent in liver, lung and spleen
Secondary accessions: Q9HBJ9

Explore the universe of human proteins at neXtProt for NOX3: NX_Q9HBY0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBY0

  • 4/5 DME Specific Peptides for NOX3 (Q9HBY0) (see all 5)
     GIGVTPF  AFEWFADLL  CLNFNCMLIL  ARASALCLNFN 

    NOX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056533.1  
    ENSEMBL proteins: 
     ENSP00000159060  

    Human Recombinant Protein Products: 
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    Novus Biologicals NOX3 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NOX3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043020NADPH oxidase complex IEA--


    NOX3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NOX3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NOX3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR000778 Cyt_b245_heavy_chain
     IPR013130 Fe3_Rdtase_TM_dom
     IPR013121 Fe_red_NAD-bd_6
     IPR013112 FAD-bd_8

    Graphical View of Domain Structure for InterPro Entry Q9HBY0

    ProtoNet protein and cluster: Q9HBY0

    2 Blocks protein families:
    IPB000778 Cytochrome B-245 heavy chain signature
    IPB013130 Ferric reductase-like transmembrane component


    UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 ferric oxidoreductase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NOX3_HUMAN, Q9HBY0
    Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a
    role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the
    perception of gravity
    Enzyme regulation: Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively
    activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by
    diphenyleneiodonium chloride

    Enzyme Numbers (IUBMB): EC 1.6.32 EC 1.6.3.-1

    miRNA
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    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNOX3 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016175superoxide-generating NADPH oxidase activity IEA--


    NOX3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NOX3:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Nox3):
     adipose tissue  behavior/neurological  growth/size  hearing/vestibular/ear  homeostasis/metabolism 

    NOX3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Leukocyte transendothelial migration
    Leukocyte transendothelial migration1.00
    2Osteoclast differentiation
    Osteoclast differentiation1.00
    3Phagosome
    Phagosome1.00
    4Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.58
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NOX3
        Rac1 Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes


    3         Kegg Pathways  (Kegg details for NOX3):
        Phagosome
    Osteoclast differentiation
    Leukocyte transendothelial migration


    NOX3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for NOX3 (ENSP000001590604) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MMP9ENSP000003614054STRING: ENSP00000361405
    VCAM1ENSP000002947284STRING: ENSP00000294728
    MAPK11ENSP000003336854STRING: ENSP00000333685
    MAPK12ENSP000002156594STRING: ENSP00000215659
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0009590detection of gravity IEA--
    GO:0009629response to gravity ----
    GO:0042554superoxide anion generation IEA--
    GO:0048840otolith development IEA--


    NOX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOX3

    3 HMDB Compounds for NOX3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    1 Novoseek chemical compound relationship for NOX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 59.3 3 17140397 (1), 19534724 (1), 17583407 (1)

    Search CenterWatch for drugs/clinical trials and news about NOX3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOX3 gene: 
    NM_015718.2  

    Unigene Cluster for NOX3:

    NADPH oxidase 3
    Hs.247776  [show with all ESTs]
    Unigene Representative Sequence: AF190122
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000159060(uc003qqm.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NOX3:
    hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNOX3 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOX3

    Additional cDNA sequence: 

    AF190122.1 AF229177.1 

    1 DOTS entry:

    DT.91995284 

    3 AceView cDNA sequences:

    AF190122 NM_015718 AF229177 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NOX3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                              -     -     -                           
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for NOX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATATACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NOX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOX3

    SOURCE GeneReport for Unigene cluster: Hs.247776
        SABiosciences Custom PCR Arrays for NOX3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NOX3 gene from 2/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NOX31 NADPH oxidase 3 73.37(n)
    73.19(a)
      428609  XM_426166.3  XP_426166.3 
    lizard
    (Anolis carolinensis)
    Reptilia NOX36
    --
    69(a)
    1 ↔ 1
    1(214512350-214553700)


    ENSEMBL Gene Tree for NOX3 (if available)
    TreeFam Gene Tree for NOX3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOX3 gene
    NOX12  CYBB2  NOX42  DUOX22  NOX52  DUOX12  
    5 SIMAP similar genes for NOX3 using alignment to 1 protein entry:     NOX3_HUMAN:
    CYBB    NOX1    DUOX2    NOX4    DUOX1

    NOX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1239 NCBI SNPs in NOX3 are shown (see all 1239    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796728571,2
    --153278861(+) GTTCTG/TTTGTA 1 -- ut310--------
    rs795733521,2
    F,--153279720(+) AGAGGA/GTGAAC 1 -- int12Minor allele frequency- G:0.02WA NA 238
    rs170862451,2
    C,F,H,--153280472(+) AAGCCA/CAGACA 1 -- int17Minor allele frequency- C:0.01NA NS EA 560
    rs1629971,2
    F,H,--153281033(+) atctgC/Tgtggt 1 -- int18Minor allele frequency- T:0.04NS EA NA MN WA 716
    rs1137884251,2
    C,--153281034(+) TCTGCG/ATGGTC 1 -- int12Minor allele frequency- A:0.04NA 122
    rs802651581,2
    --153281103(+) GTATGT/ATTTAT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs126645891,2
    H--153281210(+) TAATGC/TTAAAG 1 -- int10--------
    rs800206541,2
    F,--153281683(+) GAATCC/AAAGGA 1 -- int12Minor allele frequency- A:0.01WA NA 238
    rs735842711,2
    C,--153281733(+) ATCGCC/TCTGTG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs762156061,2
    --153281957(+) GATGGC/TTCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOX3 (155716502 - 155777037 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NOX3
         1 CNV: 7532
    Locus Specific Mutation Databases (LSDB): NOX3

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NOX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NOX3 for disorders           About GeneDecksing

    OMIM gene information: 607105    OMIM disorders: --

    5 diseases for NOX3:    About MalaCards
    rabies    asthma    immunodeficiency    hepatitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NOX3 (6 documents)

    Export disorders for NOX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOX3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NOX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. (PubMed id 11376945)1, 2, 3 Cheng G.... Lambeth J.D. (2001)
    2. Nox3 regulation by NOXO1, p47phox, and p67phox. (PubMed id 15181005)1, 2, 9 Cheng G.... Lambeth J.D. (2004)
    3. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. (PubMed id 15824103)1, 2 Ueno N.... Sumimoto H. (2005)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells. (PubMed id 10974555)1, 2 Kikuchi H.... Fukumoto M. (2000)
    6. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. (PubMed id 17140397)1, 9 Nakano Y....Nauseef W.M. (2007)
    7. Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. (PubMed id 16507994)1, 9 Ueyama T....Leto T.L. (2006)
    8. Constitutive NADPH oxidase 4 activity resides in the c omposition of the B-loop and the penultimate C terminus. (PubMed id 22277655)1 von Lohneysen K....Knaus U.G. (2012)
    9. Impaired OXPHOS complex III in breast cancer. (PubMed id 21901141)1 Owens K.M....Singh K.K. (2011)
    10. A growth factor attenuates HIV-1 Tat and morphine indu ced damage to human neurons: implication in HIV/AIDS-drug abuse cases. (PubMed id 21483469)1 Malik S....Seth P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50508 HGNC: 7890 AceView: NOX3 Ensembl:ENSG00000074771 euGenes: HUgn50508
    ECgene: NOX3 Kegg: 50508 H-InvDB: NOX3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
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