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Aliases for NOX1 Gene

Aliases for NOX1 Gene

  • NADPH Oxidase 1 2 3 5
  • Mitogenic Oxidase (Pyridine Nucleotide-Dependent Superoxide-Generating) 2 3
  • NADH/NADPH Mitogenic Oxidase Subunit P65-MOX 3 4
  • NADPH Oxidase Homolog-1 2 3
  • Mitogenic Oxidase 1 3 4
  • NOH-1 3 4
  • MOX1 3 4
  • NOH1 3 4
  • NADPH Oxidase 1 Variant NOH-1L 2
  • EC 1.-.-.- 4
  • EC 1.6.3 63
  • GP91-2 3
  • MOX-1 4
  • NOX-1 4

External Ids for NOX1 Gene

Previous GeneCards Identifiers for NOX1 Gene

  • GC0XM095379
  • GC0XM097059
  • GC0XM098134
  • GC0XM098870
  • GC0XM099904
  • GC0XM100098
  • GC0XM089897

Summaries for NOX1 Gene

Entrez Gene Summary for NOX1 Gene

  • This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for NOX1 Gene

NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include synucleinopathy and galactosemia. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include oxidoreductase activity and Rac GTPase binding. An important paralog of this gene is NOX5.

UniProtKB/Swiss-Prot for NOX1 Gene

  • NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.

Tocris Summary for NOX1 Gene

  • Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS).

Gene Wiki entry for NOX1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOX1 Gene

Genomics for NOX1 Gene

Regulatory Elements for NOX1 Gene

Genomic Location for NOX1 Gene

Chromosome:
X
Start:
100,843,324 bp from pter
End:
100,874,345 bp from pter
Size:
31,022 bases
Orientation:
Minus strand

Genomic View for NOX1 Gene

Genes around NOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOX1 Gene

Proteins for NOX1 Gene

  • Protein details for NOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S8-NOX1_HUMAN
    Recommended name:
    NADPH oxidase 1
    Protein Accession:
    Q9Y5S8
    Secondary Accessions:
    • A8K836
    • O95691
    • Q2PP02

    Protein attributes for NOX1 Gene

    Size:
    564 amino acids
    Molecular mass:
    64871 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting reactive oxygen species (ROS) production. Interacts with NOXA1 and NOXO1.

    Alternative splice isoforms for NOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOX1 Gene

Proteomics data for NOX1 Gene at MOPED

Selected DME Specific Peptides for NOX1 Gene

Post-translational modifications for NOX1 Gene

  • Glycosylation at Asn 162 and Asn 236
  • Modification sites at PhosphoSitePlus

Other Protein References for NOX1 Gene

Antibody Products

Domains & Families for NOX1 Gene

Suggested Antigen Peptide Sequences for NOX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5S8

UniProtKB/Swiss-Prot:

NOX1_HUMAN :
  • Contains 1 FAD-binding FR-type domain.
Domain:
  • Contains 1 FAD-binding FR-type domain.
  • Contains 1 ferric oxidoreductase domain.
genes like me logo Genes that share domains with NOX1: view

No data available for Gene Families for NOX1 Gene

Function for NOX1 Gene

Molecular function for NOX1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
The oxidase activity is potentiated by NOXA1 and NOXO1.
UniProtKB/Swiss-Prot Function:
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.

Enzyme Numbers (IUBMB) for NOX1 Gene

genes like me logo Genes that share phenotypes with NOX1: view

Animal Models for NOX1 Gene

MGI Knock Outs for NOX1:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NOX1 Gene

Localization for NOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOX1 Gene

Cell projection, invadopodium membrane; Multi-pass membrane protein. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOX1 Gene COMPARTMENTS Subcellular localization image for NOX1 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with NOX1: view

Pathways & Interactions for NOX1 Gene

genes like me logo Genes that share pathways with NOX1: view

Gene Ontology (GO) - Biological Process for NOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 11805326
GO:0006801 superoxide metabolic process IMP 18023288
GO:0006954 inflammatory response TAS 18347018
GO:0008217 regulation of blood pressure TAS 18347018
GO:0008284 positive regulation of cell proliferation IDA 10485709
genes like me logo Genes that share ontologies with NOX1: view

No data available for SIGNOR curated interactions for NOX1 Gene

Drugs & Compounds for NOX1 Gene

(6) Drugs for NOX1 Gene - From: Novoseek, HMDB, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Apocynin Pharma NADPH-oxidase inhibitor 0
heme Pharma Agonist 0
Diphenyleneiodonium chloride Pharma GPR3 agonist; also inhibits NOS and NADPH oxidases 0

(12) Additional Compounds for NOX1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononate
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonate
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonic acid
22594-61-2
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
ML 171
6631-94-3
NADPH reduced form tetrasodium salt
2646-71-1
genes like me logo Genes that share compounds with NOX1: view

Transcripts for NOX1 Gene

Unigene Clusters for NOX1 Gene

NADPH oxidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOX1 Gene

No ASD Table

Relevant External Links for NOX1 Gene

GeneLoc Exon Structure for
NOX1
ECgene alternative splicing isoforms for
NOX1

Expression for NOX1 Gene

mRNA expression in normal human tissues for NOX1 Gene

mRNA differential expression in normal tissues according to GTEx for NOX1 Gene

This gene is overexpressed in Colon - Transverse (x39.7).

Protein differential expression in normal tissues from HIPED for NOX1 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOX1 Gene



SOURCE GeneReport for Unigene cluster for NOX1 Gene Hs.592227

mRNA Expression by UniProt/SwissProt for NOX1 Gene

Q9Y5S8-NOX1_HUMAN
Tissue specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells.
genes like me logo Genes that share expression patterns with NOX1: view

Protein tissue co-expression partners for NOX1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NOX1 Gene

Orthologs for NOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOX1 35
  • 99.12 (n)
  • 98.9 (a)
cow
(Bos Taurus)
Mammalia NOX1 36
  • 86 (a)
OneToOne
NOX1 35
  • 88.83 (n)
  • 85.74 (a)
dog
(Canis familiaris)
Mammalia NOX1 35
  • 88.83 (n)
  • 87.59 (a)
NOX1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nox1 35
  • 86.26 (n)
  • 84.19 (a)
Nox1 36
  • 84 (a)
OneToOne
Nox1 16
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 1 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nox1 35
  • 85.2 (n)
  • 82.95 (a)
chicken
(Gallus gallus)
Aves NOX1 36
  • 72 (a)
OneToOne
NOX1 35
  • 67.81 (n)
  • 69.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24337 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nox1 35
  • 67.38 (n)
  • 69.29 (a)
Str.12356 35
zebrafish
(Danio rerio)
Actinopterygii nox1 36
  • 59 (a)
OneToMany
nox1 36
  • 59 (a)
OneToMany
LOC100538315 35
  • 62.56 (n)
  • 60.71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RBOH F 35
  • 48.85 (n)
  • 39.02 (a)
rice
(Oryza sativa)
Liliopsida Os01g0734200 35
  • 50.85 (n)
  • 41.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for NOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOX1 Gene

ENSEMBL:
Gene Tree for NOX1 (if available)
TreeFam:
Gene Tree for NOX1 (if available)

Paralogs for NOX1 Gene

Paralogs for NOX1 Gene

(3) SIMAP similar genes for NOX1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NOX1: view

Variants for NOX1 Gene

Sequence variations from dbSNP and Humsavar for NOX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2071756 - 100,850,340(+) AGCCA(C/T)GCTTG reference, missense
rs35404864 - 100,850,151(-) TCCCA(A/G)GTAGG reference, missense
rs34688635 - 100,850,206(+) CCAGT(C/T)CCCTG reference, missense
VAR_075548 -
rs1073176 -- 100,871,439(+) ATAGG(A/C/G/T)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOX1 Gene

Variant ID Type Subtype PubMed ID
esv1247987 CNV Insertion 17803354
esv2740355 CNV Deletion 23290073
nsv7011 CNV Insertion 18451855

Variation tolerance for NOX1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOX1 Gene

HapMap Linkage Disequilibrium report
NOX1
Human Gene Mutation Database (HGMD)
NOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOX1 Gene

Disorders for NOX1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOX1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
synucleinopathy
  • alpha synucleinopathies
galactosemia
  • galactose epimerase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search NOX1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NOX1_HUMAN
  • Note=Defects in NOX1 may play a role in the pathogenesis of very early onset inflammatory bowel disease (VEOIBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology diagnosed before 6 years of age. VEOIBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but the phenotype of children with onset of Crohn disease occurring younger than the age of 10 is predominantly colonic, with a lower risk of ileal disease. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:26301257}.

Relevant External Links for NOX1

Genetic Association Database (GAD)
NOX1
Human Genome Epidemiology (HuGE) Navigator
NOX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOX1
genes like me logo Genes that share disorders with NOX1: view

No data available for Genatlas for NOX1 Gene

Publications for NOX1 Gene

  1. A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1. (PMID: 10615049) Banfi B. … Krause K.-H. (Science 2000) 2 3 4 23 67
  2. Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells. (PMID: 19834108) Manea A. … Simionescu M. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 23
  3. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. (PMID: 20110267) Kroviarski Y. … Dang P.M. (FASEB J. 2010) 3 23
  4. Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis. (PMID: 20171273) Puca R. … D'Orazi G. (Free Radic. Biol. Med. 2010) 3 23
  5. Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation. (PMID: 20177149) Nam H.J. … Lee J.H. (Exp. Mol. Med. 2010) 3 23

Products for NOX1 Gene

Sources for NOX1 Gene

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