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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOX1 Gene

protein-coding   GIFtS: 57
GCID: GC0XM100098

NADPH oxidase 1
 Explore 26 diseases affiliated with
NOX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NOX1    

Aliases
for NOX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NADPH Oxidase 11 2     Mitogenic Oxidase (Pyridine Nucleotide-Dependent Superoxide-Generating)2
MOX11 2 3 5     NADPH Oxidase Homolog-12
NOH11 2 3 5     EC 1.-.-.-3
NOH-11 2 3     MOX-13
GP91-21 2     NOX-13
Mitogenic Oxidase 12 3     EC 1.6.38
NADH/NADPH Mitogenic Oxidase Subunit P65-MOX2 3     

External Ids:    HGNC: 78891   Entrez Gene: 270352   Ensembl: ENSG000000079527   OMIM: 3002255   UniProtKB: Q9Y5S83   

Export aliases for NOX1 gene to outside databases

Previous GC identifers: GC0XM095379 GC0XM097059 GC0XM098134 GC0XM098870 GC0XM099904 GC0XM089897


Summaries
for NOX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NOX1:
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer
of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other
tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine
nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron
transport mechanism, whereas NOH-1S does not contain an electron transport chain

Gene Wiki entry for NOX1


Genomic Views
for NOX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOX1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

NOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100098:  view genomic region     (about GC identifiers)

Start:
 100,098,313 bp from pter      End:
 100,129,334 bp from pter
Size:
 31,022 bases      Orientation:
 minus strand

Proteins
for NOX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8 (See protein sequence)
Recommended Name: NADPH oxidase 1  
Size: 564 amino acids; 64871 Da
Cofactor: NADP (Potential)
Cofactor: FAD (Potential)
Subunit: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts
with NOXA1 and NOXO1
Subcellular location: Cell projection, invadopodium membrane; Multi-pass membrane protein
Secondary accessions: A8K836 O95691 Q2PP02
Alternative splicing: 3 isoforms:  Q9Y5S8-1   Q9Y5S8-2   Q9Y5S8-3   

Explore the universe of human proteins at neXtProt for NOX1: NX_Q9Y5S8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5S8

    • 3 DME Specific Peptides for NOX1 (Q9Y5S8)
     GIGVTPF  ARASALCLNFN  LEWHPFTLTSAP 

    NOX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258744.1  NP_008983.2  NP_039249.1  

    ENSEMBL proteins: 
     ENSP00000362057   ENSP00000362055   ENSP00000396992   ENSP00000217885   ENSP00000362051  

    Human Recombinant Protein Products: 
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    Uscn Proteins for NOX1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005768endosome ----
    GO:0005769early endosome IDA17673675
    GO:0016020membrane ----
    GO:0016021integral to membrane IC10615049


    NOX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NOX1

    Protein Domains /
    Families
    for NOX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOX1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR000778 Cyt_b245_heavy_chain
     IPR013130 Fe3_Rdtase_TM_dom
     IPR013121 Fe_red_NAD-bd_6
     IPR013112 FAD-bd_8

    Graphical View of Domain Structure for InterPro Entry Q9Y5S8

    ProtoNet protein and cluster: Q9Y5S8

    2 Blocks protein families:
    IPB000778 Cytochrome B-245 heavy chain signature
    IPB013130 Ferric reductase-like transmembrane component


    UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 ferric oxidoreductase domain


    Function
    for NOX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
    Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other
    tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine
    nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron
    transport mechanism, whereas NOH-1S does not contain an electron transport chain
    Enzyme regulation: The oxidase activity is potentiated by NOXA1 and NOXO1

    Enzyme Numbers (IUBMB): EC 1.6.32 EC 1.-.-.-1

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOX1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NOX1 (see all 10):
    hsa-miR-548p hsa-miR-4307 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-500a hsa-miR-129-5p hsa-miR-1243 hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmid: NOX1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOX1 (see all 7)
    OriGene shRNA RFP: NOX1
    OriGene siRNA: NOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NOX1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOX1 (see all 4)
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    Search LifeMap BioReagents cell lines for NOX1

    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16636067
    GO:0016175superoxide-generating NADPH oxidase activity TAS18347018
    GO:0016491oxidoreductase activity ----
    GO:0030171voltage-gated proton channel activity IDA10615049
    GO:0046872metal ion binding IEA--


    NOX1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NOX1:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-outs for NOX1: Nox1tm1Kkr Nox1tm1Cyn
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nox1):
     cardiovascular system  homeostasis/metabolism  muscle 

    NOX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NOX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00
    2Osteoclast differentiation
    		Osteoclast differentiation1.00
    3Phagosome
    		Phagosome1.00
    4Apoptotic Pathways in Synovial Fibroblasts
    		Rac1 Pathway0.58
    5PAK Pathway
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NOX1
        Rac1 Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes

    1 BioSystems Pathway for NOX1 
        RAC1 signaling pathway


    3         Kegg Pathways  (Kegg details for NOX1):
        Phagosome
    Osteoclast differentiation
    Leukocyte transendothelial migration


    NOX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for NOX1 (Q9Y5S83 ENSP000003620574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOXA1Q86UR13, ENSP000003428484I2D: score=1 STRING: ENSP00000342848
    CYBAP134983, ENSP000002616234I2D: score=2 STRING: ENSP00000261623
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MMP2ENSP000002190704STRING: ENSP00000219070
    MMP9ENSP000003614054STRING: ENSP00000361405
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IMP11805326
    GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin IEA--
    GO:0006739NADP metabolic process IC10485709
    GO:0006746FADH2 metabolic process NAS--
    GO:0006801superoxide metabolic process IMP18023288


    NOX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOX1

    4 HMDB Compounds for NOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid2-KDN (see all 18)22594-61-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    10/11 Novoseek chemical compound relationships for NOX1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 89.7 134 19402212 (3), 16329988 (3), 18287880 (3), 15322091 (3) (see all 71)
    diphenyleneiodonium 81.1 5 18454179 (1), 20042734 (1)
    apocynin 76.5 3 15780757 (1), 18660830 (1)
    superoxide 68.7 47 19671250 (4), 12817011 (3), 16762923 (2), 17460729 (2) (see all 27)
    oxygen 67 18 15817678 (1), 18454179 (1), 14633623 (1), 15110393 (1) (see all 15)
    h2o2 45 9 14638694 (2), 15121857 (1), 15110393 (1), 15389790 (1) (see all 8)
    nitric oxide 22.3 5 18508384 (2), 17462535 (1), 19074681 (1)
    phosphatidylinositol 10 1 15121857 (1)
    phosphoinositide 8.9 1 15913451 (1)
    tyrosine 0 5 18463161 (1), 16162660 (1)

    Search CenterWatch for drugs/clinical trials and news about NOX1 

    Transcripts
    for NOX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOX1 gene (4 alternative transcripts): 
    NM_001271815.1  NM_007052.4  NM_013955.2  NM_013954.1  

    Unigene Cluster for NOX1:

    NADPH oxidase 1
    Hs.592227  [show with all ESTs]
    Unigene Representative Sequence: AF127763
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372966(uc004egj.3 uc004egl.4 uc010nne.3) ENST00000372964
    ENST00000427768 ENST00000217885 ENST00000372960

    miRNA
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    hsa-miR-548p hsa-miR-4307 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-500a hsa-miR-129-5p hsa-miR-1243 hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmid: NOX1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF127763.2 AF166327.1 AF166328.1 AJ438989.1 AK292201.1 AK313678.1 BC075014.2 BC075015.2 
    DQ424904.1 

    7 DOTS entries:

    DT.100747154  DT.40286834  DT.95126426  DT.95126429  DT.40131986  DT.95126422  DT.95126428 

    24/62 AceView cDNA sequences (see all 62):

    BC075014 AI791894 BC075015 BX956931 BX281577 AF166327 AW376979 NM_013955 
    AF166328 AW604166 AW604206 AW450431 AA493362 AW376866 AF127763 AI693765 
    AW604210 AW604209 AW850625 AW850700 AW850622 AW850699 AW604284 AJ438989 

    GeneLoc Exon Structure


    Expression
    for NOX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTACTGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NOX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOX1

    SOURCE GeneReport for Unigene cluster: Hs.592227

    UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
    Tissue specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood
    leukocytes. NOH-1S is detected only in colon and colon carcinoma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOX1: 
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              Nitric Oxide Signaling Pathway in human mouse rat
              Necrosis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX1

    Orthologs
    for NOX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOX1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NOX11 NADPH oxidase 1 67.81(n)
    69.19(a)    		   422257  NM_001101830.1  NP_001095300.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.243372 Xenopus laevis transcribed sequence with moderate similarity more 75.83(n)    CB199147.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005383151 cytochrome b-245 heavy chain-like 62.56(n)
    60.71(a)    		   100538315  XM_003199946.1  XP_003199994.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RBOH F1 respiratory burst oxidase 48.48(n)
    39.35(a)    		   842710  NM_105079.2  NP_564821.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07342001 hypothetical protein 50.71(n)
    40.57(a)    		   4324163  NM_001050700.1  NP_001044165.1 


    ENSEMBL Gene Tree for NOX1 (if available)
    TreeFam Gene Tree for NOX1 (if available) 

    Paralogs
    for NOX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOX1 gene
    CYBB2  NOX32  NOX42  DUOX22  NOX52  DUOX12  
    4 SIMAP similar genes for NOX1 using alignment to 5 protein entries:     NOX1_HUMAN (see all proteins):
    CYBB    NOX3    NOX4    DUOX1

    NOX1 for paralogs           About GeneDecksing



    Genomic Variants
    for NOX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/456 NCBI SNPs in NOX1 are shown (see all 456)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2001578461,2
    		--100097887(+) CTCTC-/CTTCTAGG 2 -- ds50010--------
    rs343600951,2
    		F--100097889(-) TCCCTAGA/-AGGAG 2 -- ds50012Minor allele frequency- -:0.04NS 94
    rs342626831,2
    		C,F,--100098280(-) GGGCTC/TTCCAT 2 -- ds50012Minor allele frequency- T:0.01NS 94
    rs354775001,2
    		C,F--100098356(-) TTATT-/CTTATTTT 4 -- ut312Minor allele frequency- CTT:0.40NS 94
    rs1484489081,2
    		C,--100098356(+) AAAAT-/AAGAATAA 2 -- ut310--------
    rs413107271,2
    		C--100098358(+) AATAAG/TAATAA 2 -- ut310--------
    rs1442724111,2
    		--100098559(+) AGGGAC/GAAAAG 2 -- ut310--------
    rs1922578251,2
    		--100098701(+) CAGTTA/GTTTTT 2 -- ut310--------
    rs341814511,2
    		C,F,--100098833(-) CCTCTC/TAAGCC 2 -- ut312Minor allele frequency- T:0.01NS 94
    rs1402892821,2
    		--100098869(+) TCAAAA/CCTGAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NOX1 (100098313 - 100129334 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NOX1: --
    Locus Specific Mutation Databases (LSDB): NOX1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOX1

    Disorders / Diseases
    for NOX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NOX1 for disorders           About GeneDecksing

    OMIM gene information: 300225    OMIM disorders: --

    20/26 diseases for NOX1 (see all 26):    About MalaCards
    chronic granulomatous disease    muscle hypertrophy    inflammatory bowel disease    vascular disease
    hepatopulmonary syndrome    dyspepsia    colon cancer    colon adenocarcinoma
    prostate cancer    liver disease    adenoma    homocysteine
    colon carcinoma    adenocarcinoma    alzheimer's disease    nephropathy
    prostatitis    asthma    atherosclerosis    hypertension

    2 diseases from the University of Copenhagen DISEASES database for NOX1:
    Hypertension     Atherosclerosis

    10 Novoseek disease relationships for NOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 49.9 12 18398843 (3), 16086438 (2), 18454179 (1), 15797632 (1) (see all 8)
    vascular diseases 37.1 2 11348997 (1), 14678249 (1)
    granulomatous disease chronic 34.4 3 12817011 (2)
    adenoma 22.6 8 15797632 (3), 16086438 (1), 18037128 (1), 16987012 (1) (see all 5)
    epithelial tumor 21.5 2 17460729 (1), 12817011 (1)
    tumors 19.4 27 18398843 (3), 15389790 (3), 19714290 (2), 17673675 (2) (see all 15)
    inflammation 13.9 6 19714290 (1), 17466292 (1), 19074681 (1), 16162660 (1) (see all 5)
    adenocarcinoma 7.99 11 18037128 (4), 15797632 (3), 16987012 (1)
    renal disease 2.3 1 19430333 (1)
    prostate cancer 0 13 15389790 (5), 18055552 (2)

    Human Genome Epidemiology (HuGE) Navigator: NOX1 (4 documents)

    Export disorders for NOX1 gene to outside databases

    Publications
    for NOX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOX1 gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with NOX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1. (PubMed id 10615049)1, 2, 3, 9 Banfi B.... Krause K.-H. (2000)
    2. Cell transformation by the superoxide-generating oxidase Mox1. (PubMed id 10485709)1, 2, 3 Suh Y.-A.... Lambeth J.D. (1999)
    3. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PubMed id 16329988)1, 2, 9 Park H.S.... Bae Y.S. (2006)
    4. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2, 9 Gianni D....Bokoch G.M. (2009)
    5. Nox1-dependent reactive oxygen generation is regulated by Rac1. (PubMed id 16636067)1, 2 Cheng G.... Lambeth J.D. (2006)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. (PubMed id 14617635)1, 2 Cheng G. and Lambeth J.D. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. (PubMed id 18398843)1, 9 Laurent E....Lambeth J.D. (2008)
    10. Nox1 induces differentiation resistance in immortalized human keratinocytes generating cells that express simple epithelial keratins. (PubMed id 17460729)1, 9 Chamulitrat W....Stremmel W. (2007)

    External Searches for NOX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing NOX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27035 HGNC: 7889 AceView: NOX1 Ensembl:ENSG00000007952 euGenes: HUgn27035
    ECgene: NOX1 Kegg: 27035 H-InvDB: NOX1

    Other Databases showing NOX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NOX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOX1 gene:
    Search GeneIP for patents involving NOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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