Aliases for NOX1 Gene
External Ids for NOX1 Gene
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for NOX1 Gene
NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include synucleinopathy and chronic granulomatous disease. Among its related pathways are PAK Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include NADP binding and superoxide-generating NADPH oxidase activity. An important paralog of this gene is NOX5.
UniProtKB/Swiss-Prot for NOX1 Gene
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS). NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of responses, including cell growth and apoptosis, angiogenesis, innate immunity, regulation of the extracellular matrix, and thyroid hormone biosynthesis.