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NOX1 Gene

protein-coding   GIFtS: 61
GCID: GC0XM100098

NADPH Oxidase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADPH Oxidase 11 2     NADH/NADPH Mitogenic Oxidase Subunit P65-MOX2 3
MOX12 3 5     NADPH Oxidase 1 Variant NOH-1L1
NOH12 3 5     GP91-22
Mitogenic Oxidase (Pyridine Nucleotide-Dependent Superoxide-Generating)1 2     EC 1.-.-.-3
NADPH Oxidase Homolog-11 2     MOX-13
Mitogenic Oxidase 12 3     NOX-13
NOH-12 3     EC 1.6.38

External Ids:    HGNC: 78891   Entrez Gene: 270352   Ensembl: ENSG000000079527   OMIM: 3002255   UniProtKB: Q9Y5S83   

Export aliases for NOX1 gene to outside databases

Previous GC identifers: GC0XM095379 GC0XM097059 GC0XM098134 GC0XM098870 GC0XM099904 GC0XM089897


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOX1 Gene:
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron
transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for NOX1 Gene:
NOX1 (NADPH oxidase 1) is a protein-coding gene. Diseases associated with NOX1 include hepatopulmonary syndrome, and chronic granulomatous disease. GO annotations related to this gene include NADP binding and superoxide-generating NADPH oxidase activity. An important paralog of this gene is CYBB.

UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other
tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine
nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron
transport mechanism, whereas NOH-1S does not contain an electron transport chain

summary for NOX1 Gene:
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that
transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS).
NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion
radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of
responses, including cell growth and apoptosis, angiogenesis, innate immunity, regulation of the
extracellular matrix, and thyroid hormone biosynthesis.

Gene Wiki entry for NOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOX1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOX1 promoter sequence
   Search Chromatin IP Primers for NOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

NOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOX1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100098:  view genomic region     (about GC identifiers)

Start:
100,098,313 bp from pter      End:
100,129,334 bp from pter
Size:
31,022 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8 (See protein sequence)
Recommended Name: NADPH oxidase 1  
Size: 564 amino acids; 64871 Da
Cofactor: NADP (Potential)
Cofactor: FAD (Potential)
Subunit: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production.
Interacts with NOXA1 and NOXO1
Secondary accessions: A8K836 O95691 Q2PP02
Alternative splicing: 3 isoforms:  Q9Y5S8-1   Q9Y5S8-2   Q9Y5S8-3   

Explore the universe of human proteins at neXtProt for NOX1: NX_Q9Y5S8

Explore proteomics data for NOX1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn162, Asn236
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NOX1 (Q9Y5S8)
     GIGVTPF  ARASALCLNFN  LEWHPFTLTSAP 


    See NOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258744.1  NP_008983.2  NP_039249.1  

    ENSEMBL proteins: 
     ENSP00000362057   ENSP00000362055   ENSP00000396992   ENSP00000217885   ENSP00000362051  

    NOX1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NOX1
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    Novus Biologicals NOX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOX1

    NOX1 Antibody Products:

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    Novus Biologicals NOX1 Antibodies
    Abcam antibodies for NOX1
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    LSBio Antibodies in human, mouse, rat for NOX1

    NOX1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NOX1
    Cloud-Clone Corp. CLIAs for NOX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR000778 Cyt_b245_heavy_chain
     IPR013130 Fe3_Rdtase_TM_dom
     IPR013121 Fe_red_NAD-bd_6
     IPR013112 FAD-bd_8

    Graphical View of Domain Structure for InterPro Entry Q9Y5S8

    ProtoNet protein and cluster: Q9Y5S8

    2 Blocks protein domains:
    IPB000778 Cytochrome B-245 heavy chain signature
    IPB013130 Ferric reductase-like transmembrane component


    UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 ferric oxidoreductase domain


    NOX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOX1_HUMAN, Q9Y5S8
    Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other
    tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine
    nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron
    transport mechanism, whereas NOH-1S does not contain an electron transport chain
    Enzyme regulation: The oxidase activity is potentiated by NOXA1 and NOXO1

         Enzyme Numbers (IUBMB): EC 1.6.32 EC 1.-.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16636067
    GO:0016175superoxide-generating NADPH oxidase activity TAS10485709
    GO:0016491oxidoreductase activity ----
    GO:0030171voltage-gated proton channel activity IDA10615049
    GO:0046872metal ion binding IEA--
         
    NOX1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOX1:
     Decreased Hepatitis C virus re 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nox1):
     cardiovascular system  cellular  digestive/alimentary  homeostasis/metabolism  immune system 
     muscle 

    NOX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOX1: Nox1tm1Kkr Nox1tm1Cyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOX1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOX1 (see all 10):
    hsa-miR-548p hsa-miR-4307 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-500a hsa-miR-129-5p hsa-miR-1243 hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidNOX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOX1
    Predesigned siRNA for gene silencing in human, mouse, rat NOX1

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for NOX1 (see all 12)
    OriGene ORF clones in mouse, rat for NOX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOX1 (NM_004571)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOX1_HUMAN, Q9Y5S8: Cell projection, invadopodium membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome4
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005768endosome ----
    GO:0005769early endosome IDA17673675
    GO:0016020membrane ----
    GO:0016021integral component of membrane IC10615049

    NOX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOX1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4CDC42 signaling events
    RAC1 signaling pathway0.34
    5Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOX1
        Rac1 Pathway
    Antioxidant Action of Vitamin-C
    Transendothelial Migration of Leukocytes

    1 BioSystems Pathway for NOX1
        RAC1 signaling pathway


    4 Kegg Pathways  (Kegg details for NOX1):
        HIF-1 signaling pathway
    Phagosome
    Osteoclast differentiation
    Leukocyte transendothelial migration


    NOX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOX1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for NOX1 (Q9Y5S83 ENSP000003620574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOXA1Q86UR13, ENSP000003428484I2D: score=1 STRING: ENSP00000342848
    CYBAP134983, ENSP000002616234I2D: score=2 STRING: ENSP00000261623
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MMP2ENSP000002190704STRING: ENSP00000219070
    MMP9ENSP000003614054STRING: ENSP00000361405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IMP11805326
    GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin IEA--
    GO:0006739NADP metabolic process IC10485709
    GO:0006746FADH2 metabolic process ----
    GO:0006801superoxide metabolic process IMP18023288

    NOX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NOX1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ApocyninNADPH-oxidase inhibitor[498-02-2]
    ML 171Selective NADPH oxidase 1 (NOX1) inhibitor[6631-94-3]

    4 HMDB Compounds for NOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid2-KDN (see all 18)22594-61-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--

    Selected Novoseek inferred chemical compound relationships for NOX1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 89.7 134 19402212 (3), 16329988 (3), 18287880 (3), 15322091 (3) (see all 71)
    diphenyleneiodonium 81.1 5 18454179 (1), 20042734 (1)
    apocynin 76.5 3 15780757 (1), 18660830 (1)
    superoxide 68.7 47 19671250 (4), 12817011 (3), 16762923 (2), 17460729 (2) (see all 27)
    oxygen 67 18 15817678 (1), 18454179 (1), 14633623 (1), 15110393 (1) (see all 15)
    h2o2 45 9 14638694 (2), 15121857 (1), 15110393 (1), 15389790 (1) (see all 8)
    nitric oxide 22.3 5 18508384 (2), 17462535 (1), 19074681 (1)
    phosphatidylinositol 10 1 15121857 (1)
    phosphoinositide 8.9 1 15913451 (1)
    tyrosine 0 5 18463161 (1), 16162660 (1)



    NOX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOX1 gene (4 alternative transcripts): 
    NM_001271815.1  NM_007052.4  NM_013955.2  NM_013954.1  

    Unigene Cluster for NOX1:

    NADPH oxidase 1
    Hs.592227  [show with all ESTs]
    Unigene Representative Sequence: AF127763
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372966(uc004egj.3 uc004egl.4 uc010nne.3) ENST00000372964
    ENST00000427768 ENST00000217885 ENST00000372960
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NOX1 (see all 10):
    hsa-miR-548p hsa-miR-4307 hsa-miR-513a-3p hsa-miR-1261 hsa-miR-500a hsa-miR-129-5p hsa-miR-1243 hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidNOX1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NOX1 (NM_004571)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOX1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NOX1
      QuantiFast Probe-based Assays in human, mouse, rat NOX1

    Additional mRNA sequence: 

    AF127763.2 AF166327.1 AF166328.1 AJ438989.1 AK292201.1 AK313678.1 BC075014.2 BC075015.2 
    DQ424904.1 

    7 DOTS entries:

    DT.100747154  DT.40286834  DT.95126426  DT.95126429  DT.40131986  DT.95126422  DT.95126428 

    Selected AceView cDNA sequences (see all 62):

    AW376979 BX956931 AI791894 NM_013955 AW604166 AF166327 BX281577 BC075014 
    AF166328 BC075015 AA554138 AW850700 AW377061 AI285296 AW604208 AW604206 
    NM_013954 AW376980 AA493362 AF166326 AJ438989 AW604284 AF127763 AI693765 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACTGTCA
    NOX1 Expression
    About this image


    NOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    NOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592227

    UniProtKB/Swiss-Prot: NOX1_HUMAN, Q9Y5S8
    Tissue specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral
    blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOX1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Necrosis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOX1
    QuantiTect SYBR Green Assays in human, mouse, rat NOX1
    QuantiFast Probe-based Assays in human, mouse, rat NOX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nox11 , 5 NADPH oxidase 11, 5 86.26(n)1
    84.19(a)1
      X (55.69 cM)5
    2370381  NM_172203.21  NP_757340.11 
     1340864215 
    chicken
    (Gallus gallus)
    Aves NOX11 NADPH oxidase 1 67.81(n)
    69.68(a)
      422257  NM_001101830.1  NP_001095300.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243372 Xenopus laevis transcribed sequence with moderate similarity more 75.83(n)    CB199147.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005383151 cytochrome b-245 heavy chain-like 62.56(n)
    60.71(a)
      100538315  XM_003199946.2  XP_003199994.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RBOH F1 RBOH F 48.85(n)
    39.02(a)
      842710  NM_105079.2  NP_564821.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07342001 Os01g0734200 50.85(n)
    41.14(a)
      4324163  NM_001050700.1  NP_001044165.1 


    ENSEMBL Gene Tree for NOX1 (if available)
    TreeFam Gene Tree for NOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOX1 gene
    CYBB2  NOX32  NOX42  DUOX22  DUOX12  NOX52  
    3 SIMAP similar genes for NOX1 using alignment to 5 protein entries:     NOX1_HUMAN (see all proteins):
    CYBB    NOX3    NOX4

    NOX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOX1 (see all 578)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001578461,2
    C--100064183(+) TCTCT-/CTTTTCTA 2 -- ds50010--------
    rs343600951,2
    F--100064185(-) TCCCTAGA/-AGGAG 2 -- ds50012Minor allele frequency- -:0.04NS 94
    rs342626831,2
    C,F--100064576(-) GGGCTC/TTCCAT 2 -- ds50012Minor allele frequency- T:0.01NS 94
    rs1442724111,2
    --100064852(+) AGGGAC/GAAAAG 2 -- ut310--------
    rs1922578251,2
    --100064994(+) CAGTTA/GTTTTT 2 -- ut310--------
    rs341814511,2
    C,F--100065126(-) CCTCTC/TAAGCC 2 -- ut312Minor allele frequency- T:0.01NS 94
    rs1402892821,2
    --100065162(+) TCAAAA/CCTGAC 2 -- ut310--------
    rs340095921,2
    C,F--100065168(-) GGTCTC/TGTCAG 2 -- ut312Minor allele frequency- T:0.01NS 94
    rs1845928011,2
    --100065552(+) ACTCTC/GAGCAC 2 -- int10--------
    rs360816921,2
    F--100065584(-) GTCATC/GTGTGT 2 -- int12Minor allele frequency- G:0.01NS 94

    HapMap Linkage Disequilibrium report for NOX1 (100098313 - 100129334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NOX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740355CNV Deletion23290073
    nsv7011CNV Insertion18451855
    esv1247987CNV Insertion17803354

    Locus Specific Mutation Databases (LSDB): NOX1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300225    OMIM disorders: --

    Selected diseases for NOX1 (see all 30):    
    About MalaCards
    hepatopulmonary syndrome    chronic granulomatous disease    hiv/aids    dyspepsia
    vascular disease    estrogen-receptor negative breast cancer    colon adenocarcinoma    hypoxia
    sickle cell disease    thyroiditis    inflammatory bowel disease    dementia
    endotheliitis    adenoma    liver disease    hiv-1
    atherosclerosis    adenocarcinoma    asthma    hypertension

    2 diseases from the University of Copenhagen DISEASES database for NOX1:
    Hypertension     Atherosclerosis

    NOX1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for NOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 49.9 12 18398843 (3), 16086438 (2), 18454179 (1), 15797632 (1) (see all 8)
    vascular diseases 37.1 2 11348997 (1), 14678249 (1)
    granulomatous disease chronic 34.4 3 12817011 (2)
    adenoma 22.6 8 15797632 (3), 16086438 (1), 18037128 (1), 16987012 (1) (see all 5)
    epithelial tumor 21.5 2 17460729 (1), 12817011 (1)
    tumors 19.4 27 18398843 (3), 15389790 (3), 19714290 (2), 17673675 (2) (see all 15)
    inflammation 13.9 6 19714290 (1), 17466292 (1), 19074681 (1), 16162660 (1) (see all 5)
    adenocarcinoma 7.99 11 18037128 (4), 15797632 (3), 16987012 (1)
    renal disease 2.3 1 19430333 (1)
    prostate cancer 0 13 15389790 (5), 18055552 (2)

    Genetic Association Database (GAD): NOX1
    Human Genome Epidemiology (HuGE) Navigator: NOX1 (4 documents)

    Export disorders for NOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOX1 gene, integrated from 10 sources (see all 219):
    (articles sorted by number of sources associating them with NOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1. (PubMed id 10615049)1, 2, 3, 9 Banfi B.... Krause K.-H. (Science 2000)
    2. Cell transformation by the superoxide-generating oxidase Mox1. (PubMed id 10485709)1, 2, 3 Suh Y.-A.... Lambeth J.D. (Nature 1999)
    3. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PubMed id 16329988)1, 2, 9 Park H.S.... Bae Y.S. (Biochem. Biophys. Res. Commun. 2006)
    4. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PubMed id 19755710)1, 2, 9 Gianni D....Bokoch G.M. (Sci. Signal. 2009)
    5. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals. (PubMed id 19415232)1, 4 Lim S.C....Chia K.S. (Diabetologia 2009)
    8. Nox1-dependent reactive oxygen generation is regulated by Rac1. (PubMed id 16636067)1, 2 Cheng G.... Lambeth J.D. (J. Biol. Chem. 2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. (PubMed id 14617635)1, 2 Cheng G. and Lambeth J.D. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27035 HGNC: 7889 AceView: NOX1 Ensembl:ENSG00000007952 euGenes: HUgn27035
    ECgene: NOX1 Kegg: 27035 H-InvDB: NOX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOX1 gene:
    Search GeneIP for patents involving NOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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