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Aliases for NOX1 Gene

Aliases for NOX1 Gene

  • NADPH Oxidase 1 2 3
  • MOX1 3 4 6
  • NOH1 3 4 6
  • Mitogenic Oxidase (Pyridine Nucleotide-Dependent Superoxide-Generating) 2 3
  • NADH/NADPH Mitogenic Oxidase Subunit P65-MOX 3 4
  • NADPH Oxidase Homolog-1 2 3
  • Mitogenic Oxidase 1 3 4
  • NOH-1 3 4
  • NADPH Oxidase 1 Variant NOH-1L 2
  • EC 1.-.-.- 4
  • EC 1.6.3 64
  • GP91-2 3
  • MOX-1 4
  • NOX-1 4

External Ids for NOX1 Gene

Summaries for NOX1 Gene

Entrez Gene Summary for NOX1 Gene

  • This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for NOX1 Gene

NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include synucleinopathy and chronic granulomatous disease. Among its related pathways are PAK Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include NADP binding and superoxide-generating NADPH oxidase activity. An important paralog of this gene is NOX5.

UniProtKB/Swiss-Prot for NOX1 Gene

  • NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain

Tocris Summary for NOX1 Gene

  • Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS). NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of responses, including cell growth and apoptosis, angiogenesis, innate immunity, regulation of the extracellular matrix, and thyroid hormone biosynthesis.

Gene Wiki entry for NOX1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOX1 Gene

Genomics for NOX1 Gene

Genomic Location for NOX1 Gene

Start:
100,843,324 bp from pter
End:
100,874,345 bp from pter
Size:
31,022 bases
Orientation:
Minus strand

Genomic View for NOX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOX1 Gene

Regulatory Elements for NOX1 Gene

Proteins for NOX1 Gene

  • Protein details for NOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S8-NOX1_HUMAN
    Recommended name:
    NADPH oxidase 1
    Protein Accession:
    Q9Y5S8
    Secondary Accessions:
    • A8K836
    • O95691
    • Q2PP02

    Protein attributes for NOX1 Gene

    Size:
    564 amino acids
    Molecular mass:
    64871 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=NADP(+); Xref=ChEBI:CHEBI:58349;
    Quaternary structure:
    • NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.

    Alternative splice isoforms for NOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOX1 Gene

Proteomics data for NOX1 Gene at MOPED

Selected DME Specific Peptides for NOX1 Gene

Post-translational modifications for NOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn162 and Asn236

Other Protein References for NOX1 Gene

Domains for NOX1 Gene

UniProtKB/Swiss-Prot:

NOX1_HUMAN
Domain:
  • Contains 1 FAD-binding FR-type domain.:
    • Q9Y5S8
  • Contains 1 ferric oxidoreductase domain.:
    • Q9Y5S8
genes like me logo Genes that share domains with NOX1: view

No data available for Gene Families for NOX1 Gene

Function for NOX1 Gene

Molecular function for NOX1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: The oxidase activity is potentiated by NOXA1 and NOXO1.
UniProtKB/Swiss-Prot Function: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain

Enzyme Numbers (IUBMB) for NOX1 Gene

Gene Ontology (GO) - Molecular Function for NOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16636067
GO:0016175 superoxide-generating NADPH oxidase activity TAS 10485709
GO:0016491 oxidoreductase activity --
GO:0030171 voltage-gated proton channel activity IDA 10615049
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NOX1: view
genes like me logo Genes that share phenotypes with NOX1: view

Animal Models for NOX1 Gene

MGI Knock Outs for NOX1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for NOX1 Gene

Localization for NOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOX1 Gene

Cell projection, invadopodium membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOX1 Gene COMPARTMENTS Subcellular localization image for NOX1 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome --
GO:0005769 early endosome IDA 17673675
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with NOX1: view

Pathways for NOX1 Gene

genes like me logo Genes that share pathways with NOX1: view

Pathways by source for NOX1 Gene

Gene Ontology (GO) - Biological Process for NOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 11805326
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin IEA --
GO:0006739 NADP metabolic process IC 10485709
GO:0006801 superoxide metabolic process IMP 18023288
GO:0006954 inflammatory response TAS 18347018
genes like me logo Genes that share ontologies with NOX1: view

Compounds for NOX1 Gene

(2) Tocris Compounds for NOX1 Gene

Compound Action Cas Number
Apocynin NADPH-oxidase inhibitor [498-02-2]
ML 171 Selective NADPH oxidase 1 (NOX1) inhibitor [6631-94-3]

(4) HMDB Compounds for NOX1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
22594-61-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Heme
  • (protoporphyrinato)iron
14875-96-8
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8

(11) Novoseek inferred chemical compound relationships for NOX1 Gene

Compound -log(P) Hits PubMed IDs
nadph 89.7 97
diphenyleneiodonium 81.1 2
apocynin 76.5 2
superoxide 68.7 38
oxygen 67 15
genes like me logo Genes that share compounds with NOX1: view

Transcripts for NOX1 Gene

Unigene Clusters for NOX1 Gene

NADPH oxidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOX1 Gene

No ASD Table

Relevant External Links for NOX1 Gene

GeneLoc Exon Structure for
NOX1
ECgene alternative splicing isoforms for
NOX1

Expression for NOX1 Gene

mRNA expression in normal human tissues for NOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOX1 Gene

This gene is overexpressed in Colon - Transverse (39.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOX1 Gene

SOURCE GeneReport for Unigene cluster for NOX1 Gene Hs.592227

mRNA Expression by UniProt/SwissProt for NOX1 Gene

Q9Y5S8-NOX1_HUMAN
Tissue specificity: NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells
genes like me logo Genes that share expressions with NOX1: view

Orthologs for NOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOX1 36
  • 99.12 (n)
  • 98.9 (a)
cow
(Bos Taurus)
Mammalia NOX1 36
  • 88.83 (n)
  • 85.74 (a)
NOX1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOX1 36
  • 88.83 (n)
  • 87.59 (a)
NOX1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nox1 36
  • 86.26 (n)
  • 84.19 (a)
Nox1 16
Nox1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 1 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Nox1 36
  • 85.2 (n)
  • 82.95 (a)
chicken
(Gallus gallus)
Aves NOX1 36
  • 67.81 (n)
  • 69.68 (a)
NOX1 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24337 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nox1 36
  • 67.38 (n)
  • 69.29 (a)
Str.12356 36
zebrafish
(Danio rerio)
Actinopterygii LOC100538315 36
  • 62.56 (n)
  • 60.71 (a)
nox1 37
  • 59 (a)
OneToMany
nox1 37
  • 59 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RBOH F 36
  • 48.85 (n)
  • 39.02 (a)
rice
(Oryza sativa)
Liliopsida Os01g0734200 36
  • 50.85 (n)
  • 41.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for NOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOX1 Gene

ENSEMBL:
Gene Tree for NOX1 (if available)
TreeFam:
Gene Tree for NOX1 (if available)

Paralogs for NOX1 Gene

Paralogs for NOX1 Gene

Selected SIMAP similar genes for NOX1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NOX1: view

Variants for NOX1 Gene

Sequence variations from dbSNP and Humsavar for NOX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1073176 -- 100,871,439(-) ATAGG(C/T)GCTAA intron-variant
rs1476011 -- 100,850,019(+) TGTTC(C/T)CATGG intron-variant
rs2071756 - 100,850,340(+) AGCCA(C/T)GCTTG missense, reference
rs2266916 -- 100,865,506(-) ATCCA(C/T)AGTCA intron-variant
rs4827881 -- 100,874,684(+) GCATA(A/C)CAGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NOX1 Gene

Variant ID Type Subtype PubMed ID
esv1247987 CNV Insertion 17803354
esv2740355 CNV Deletion 23290073
nsv7011 CNV Insertion 18451855

Relevant External Links for NOX1 Gene

HapMap Linkage Disequilibrium report
NOX1
Locus Specific Mutation Databases (LSDB)
NOX1

Disorders for NOX1 Gene

(2) University of Copenhagen DISEASES for NOX1 Gene

(10) Novoseek inferred disease relationships for NOX1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 49.9 11
vascular diseases 37.1 2
granulomatous disease chronic 34.4 2
adenoma 22.6 7
epithelial tumor 21.5 2

Relevant External Links for NOX1

Genetic Association Database (GAD)
NOX1
Human Genome Epidemiology (HuGE) Navigator
NOX1
genes like me logo Genes that share disorders with NOX1: view

No data available for UniProtKB/Swiss-Prot for NOX1 Gene

Publications for NOX1 Gene

  1. A mammalian H+ channel, generated through alternative splicing of the NADPH oxidase homolog NOH-1. (PMID: 10615049) Banfi B. … Krause K.-H. (Science 2000) 2 3 4 23
  2. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PMID: 16329988) Park H.S. … Bae Y.S. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. (PMID: 19755710) Gianni D. … Bokoch G.M. (Sci. Signal. 2009) 3 4 23
  4. Cell transformation by the superoxide-generating oxidase Mox1. (PMID: 10485709) Suh Y.-A. … Lambeth J.D. (Nature 1999) 2 3 4
  5. Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis. (PMID: 20171273) Puca R. … D'Orazi G. (Free Radic. Biol. Med. 2010) 3 23

Products for NOX1 Gene

Sources for NOX1 Gene

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