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Aliases for NOVA2 Gene

Aliases for NOVA2 Gene

  • Neuro-Oncological Ventral Antigen 2 2 3 4
  • NOVA3 3 4 6
  • ANOVA 3 4 6
  • Astrocytic NOVA1-Like RNA-Binding Protein 3 4
  • Neuro-Oncological Ventral Antigen 3 2 3
  • RNA-Binding Protein Nova-2 3

External Ids for NOVA2 Gene

Previous HGNC Symbols for NOVA2 Gene

  • NOVA3

Previous GeneCards Identifiers for NOVA2 Gene

  • GC19M047086
  • GC19M046833
  • GC19M051118
  • GC19M051134
  • GC19M046442
  • GC19M042871

Summaries for NOVA2 Gene

GeneCards Summary for NOVA2 Gene

NOVA2 (Neuro-Oncological Ventral Antigen 2) is a Protein Coding gene. Diseases associated with NOVA2 include paraneoplastic neurologic disorders. GO annotations related to this gene include RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for NOVA2 Gene

  • May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOVA2 Gene

Genomics for NOVA2 Gene

Regulatory Elements for NOVA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOVA2 Gene

Start:
45,933,734 bp from pter
End:
45,973,546 bp from pter
Size:
39,813 bases
Orientation:
Minus strand

Genomic View for NOVA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOVA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOVA2 Gene

Proteins for NOVA2 Gene

  • Protein details for NOVA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNW9-NOVA2_HUMAN
    Recommended name:
    RNA-binding protein Nova-2
    Protein Accession:
    Q9UNW9
    Secondary Accessions:
    • O43267
    • Q9UEA1

    Protein attributes for NOVA2 Gene

    Size:
    492 amino acids
    Molecular mass:
    49009 Da
    Quaternary structure:
    • Interacts with PTBP2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAB88661.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOVA2 Gene

neXtProt entry for NOVA2 Gene

Proteomics data for NOVA2 Gene at MOPED

Post-translational modifications for NOVA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOVA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOVA2 Gene

Domains for NOVA2 Gene

Protein Domains for NOVA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOVA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNW9

UniProtKB/Swiss-Prot:

NOVA2_HUMAN :
  • Q9UNW9
Domain:
  • The third KH domain (KH3) recognizes specifically 5-UCAY-3
  • Contains 3 KH domains.
genes like me logo Genes that share domains with NOVA2: view

No data available for Gene Families for NOVA2 Gene

Function for NOVA2 Gene

Molecular function for NOVA2 Gene

GENATLAS Biochemistry: neuro-oncological ventral antigen 2
UniProtKB/Swiss-Prot Function: May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.

Gene Ontology (GO) - Molecular Function for NOVA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 10735272
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NOVA2: view

Phenotypes for NOVA2 Gene

genes like me logo Genes that share phenotypes with NOVA2: view

Animal Models for NOVA2 Gene

MGI Knock Outs for NOVA2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NOVA2 Gene

Localization for NOVA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOVA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOVA2 Gene COMPARTMENTS Subcellular localization image for NOVA2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOVA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NOVA2: view

Pathways for NOVA2 Gene

SuperPathways for NOVA2 Gene

No Data Available

Interacting Proteins for NOVA2 Gene

Gene Ontology (GO) - Biological Process for NOVA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051252 regulation of RNA metabolic process IEA --
genes like me logo Genes that share ontologies with NOVA2: view

No data available for Pathways by source for NOVA2 Gene

Transcripts for NOVA2 Gene

Unigene Clusters for NOVA2 Gene

Neuro-oncological ventral antigen 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOVA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NOVA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOVA2 Gene

No ASD Table

Relevant External Links for NOVA2 Gene

GeneLoc Exon Structure for
NOVA2
ECgene alternative splicing isoforms for
NOVA2

Expression for NOVA2 Gene

mRNA expression in normal human tissues for NOVA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOVA2 Gene

This gene is overexpressed in Brain - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOVA2 Gene

SOURCE GeneReport for Unigene cluster for NOVA2 Gene Hs.375439

mRNA Expression by UniProt/SwissProt for NOVA2 Gene

Q9UNW9-NOVA2_HUMAN
Tissue specificity: Brain. Expression restricted to astrocytes
genes like me logo Genes that share expressions with NOVA2: view

In Situ Assay Products

Orthologs for NOVA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOVA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOVA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOVA2 35
  • 93.56 (n)
  • 99.8 (a)
NOVA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOVA2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nova2 35
  • 90.99 (n)
  • 98.58 (a)
Nova2 16
Nova2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOVA2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nova2 35
  • 89.05 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nova2 35
  • 68.1 (n)
  • 77.75 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6502 35
nova1 36
  • 77 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta ps 36
  • 28 (a)
OneToMany
ps 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea Y59A8B.10 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for NOVA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOVA2 Gene

ENSEMBL:
Gene Tree for NOVA2 (if available)
TreeFam:
Gene Tree for NOVA2 (if available)

Paralogs for NOVA2 Gene

Paralogs for NOVA2 Gene

Selected SIMAP similar genes for NOVA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NOVA2: view

Variants for NOVA2 Gene

Sequence variations from dbSNP and Humsavar for NOVA2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs590130 -- 45,939,223(+) TTCCC(A/C)CCTAG intron-variant, utr-variant-3-prime
rs590187 -- 45,939,275(+) GGGAA(A/C)TTTGG intron-variant, utr-variant-3-prime
rs590189 -- 45,939,277(+) GAAAT(C/T)TGGGG intron-variant, utr-variant-3-prime
rs606451 -- 45,955,585(-) ACCGC(A/T)CCCGG intron-variant
rs646805 -- 45,940,440(+) CGAGA(A/T)GAGGC frameshift-variant, reference

Structural Variations from Database of Genomic Variants (DGV) for NOVA2 Gene

Variant ID Type Subtype PubMed ID
esv2674835 CNV Deletion 23128226

Relevant External Links for NOVA2 Gene

HapMap Linkage Disequilibrium report
NOVA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOVA2 Gene

Disorders for NOVA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NOVA2 Gene including...

Search for NOVA2 Gene in MalaCards »

Relevant External Links for NOVA2

Genetic Association Database (GAD)
NOVA2
genes like me logo Genes that share disorders with NOVA2: view

No data available for UniProtKB/Swiss-Prot for NOVA2 Gene

Publications for NOVA2 Gene

  1. Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. (PMID: 10368286) Lewis H.A. … Burley S.K. (Structure 1999) 2 3 4
  2. The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. (PMID: 9789075) Yang Y.Y. … Darnell R.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. ANOVA, a putative astrocytic RNA binding protein gene that maps to chromosome 19q13.3. (PMID: 10735272) Ueki K. … Louis D.N. (Neurogenetics 1997) 3 4 23
  4. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (PMID: 9344654) Fletcher C.F. … Darnell R.B. (Genomics 1997) 2 3
  5. Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. (PMID: 10676814) Lewis H.A. … Burley S.K. (Cell 2000) 3 4

Products for NOVA2 Gene

Sources for NOVA2 Gene

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