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Aliases for NOVA2 Gene

Aliases for NOVA2 Gene

  • Neuro-Oncological Ventral Antigen 2 2 3 4 5
  • Astrocytic NOVA1-Like RNA-Binding Protein 3 4
  • Neuro-Oncological Ventral Antigen 3 2 3
  • NOVA3 3 4
  • ANOVA 3 4

External Ids for NOVA2 Gene

Previous HGNC Symbols for NOVA2 Gene

  • NOVA3

Previous GeneCards Identifiers for NOVA2 Gene

  • GC19M047086
  • GC19M046833
  • GC19M051118
  • GC19M051134
  • GC19M046442
  • GC19M042871

Summaries for NOVA2 Gene

GeneCards Summary for NOVA2 Gene

NOVA2 (Neuro-Oncological Ventral Antigen 2) is a Protein Coding gene. Diseases associated with NOVA2 include Fragile X Syndrome and Partial Fetal Alcohol Syndrome. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for NOVA2 Gene

  • May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOVA2 Gene

Genomics for NOVA2 Gene

Regulatory Elements for NOVA2 Gene

Enhancers for NOVA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOVA2 on UCSC Golden Path with GeneCards custom track

Promoters for NOVA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOVA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOVA2 Gene

45,933,734 bp from pter
45,973,546 bp from pter
39,813 bases
Minus strand

Genomic View for NOVA2 Gene

Genes around NOVA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOVA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOVA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOVA2 Gene

Proteins for NOVA2 Gene

  • Protein details for NOVA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein Nova-2
    Protein Accession:
    Secondary Accessions:
    • O43267
    • Q9UEA1

    Protein attributes for NOVA2 Gene

    492 amino acids
    Molecular mass:
    49009 Da
    Quaternary structure:
    • Interacts with PTBP2; the interaction is direct.
    • Sequence=AAB88661.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOVA2 Gene

neXtProt entry for NOVA2 Gene

Proteomics data for NOVA2 Gene at MOPED

Post-translational modifications for NOVA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOVA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for Nova2

No data available for DME Specific Peptides for NOVA2 Gene

Domains & Families for NOVA2 Gene

Protein Domains for NOVA2 Gene


Suggested Antigen Peptide Sequences for NOVA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The third KH domain (KH3) recognizes specifically 5-UCAY-3.
  • The third KH domain (KH3) recognizes specifically 5-UCAY-3.
  • Contains 3 KH domains.
genes like me logo Genes that share domains with NOVA2: view

No data available for Gene Families for NOVA2 Gene

Function for NOVA2 Gene

Molecular function for NOVA2 Gene

GENATLAS Biochemistry:
neuro-oncological ventral antigen 2
UniProtKB/Swiss-Prot Function:
May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.

Gene Ontology (GO) - Molecular Function for NOVA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NOVA2: view

Phenotypes for NOVA2 Gene

genes like me logo Genes that share phenotypes with NOVA2: view

Animal Models for NOVA2 Gene

MGI Knock Outs for NOVA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOVA2 Gene

Localization for NOVA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOVA2 Gene

Subcellular locations from

Jensen Localization Image for NOVA2 Gene COMPARTMENTS Subcellular localization image for NOVA2 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NOVA2 Gene

Pathways & Interactions for NOVA2 Gene

SuperPathways for NOVA2 Gene

No Data Available

Interacting Proteins for NOVA2 Gene

Gene Ontology (GO) - Biological Process for NOVA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOVA2 Gene

Drugs & Compounds for NOVA2 Gene

No Compound Related Data Available

Transcripts for NOVA2 Gene

Unigene Clusters for NOVA2 Gene

Neuro-oncological ventral antigen 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOVA2 Gene

No ASD Table

Relevant External Links for NOVA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOVA2 Gene

mRNA expression in normal human tissues for NOVA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOVA2 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for NOVA2 Gene

This gene is overexpressed in Fetal Brain (17.5), Pancreas (10.0), Fetal gut (7.7), Plasma (7.6), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOVA2 Gene

SOURCE GeneReport for Unigene cluster for NOVA2 Gene Hs.375439

mRNA Expression by UniProt/SwissProt for NOVA2 Gene

Tissue specificity: Brain. Expression restricted to astrocytes.
genes like me logo Genes that share expression patterns with NOVA2: view

Protein tissue co-expression partners for NOVA2 Gene

- Elite partner

Primer Products

Orthologs for NOVA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOVA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOVA2 35
  • 93.56 (n)
  • 99.8 (a)
NOVA2 36
  • 100 (a)
(Mus musculus)
Mammalia Nova2 35
  • 90.99 (n)
  • 98.58 (a)
Nova2 16
Nova2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nova2 35
  • 89.05 (n)
  • 95.82 (a)
(Canis familiaris)
Mammalia NOVA2 36
  • 93 (a)
(Monodelphis domestica)
Mammalia NOVA2 36
  • 89 (a)
(Pan troglodytes)
Mammalia NOVA2 36
  • 100 (a)
(Gallus gallus)
Aves -- 36
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nova2 35
  • 68.1 (n)
  • 77.75 (a)
(Danio rerio)
Actinopterygii Dr.6502 35
nova1 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta ps 37
  • 50 (a)
ps 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y59A8B.10 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for NOVA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOVA2 Gene

Gene Tree for NOVA2 (if available)
Gene Tree for NOVA2 (if available)

Paralogs for NOVA2 Gene

Paralogs for NOVA2 Gene

(1) SIMAP similar genes for NOVA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NOVA2: view

Variants for NOVA2 Gene

Sequence variations from dbSNP and Humsavar for NOVA2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257625 -- 45,971,170(+) CCCAT(A/G)TCTCA intron-variant
rs8101795 -- 45,966,912(+) AAATC(A/C/G)TTGCT intron-variant
rs8103184 -- 45,945,841(+) ttatt(A/T)ttttt intron-variant
rs8103856 -- 45,954,867(+) gtgtg(C/T)gtgtg intron-variant, upstream-variant-2KB
rs67204699 -- 45,935,429(+) GTGTT(A/G)TCACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOVA2 Gene

Variant ID Type Subtype PubMed ID
esv2674835 CNV Deletion 23128226

Variation tolerance for NOVA2 Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOVA2 Gene

Disorders for NOVA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOVA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fragile x syndrome
  • fragile x mental retardation syndrome
partial fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NOVA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOVA2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NOVA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOVA2 Gene

Publications for NOVA2 Gene

  1. Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. (PMID: 10368286) Lewis H.A. … Burley S.K. (Structure 1999) 2 3 4 67
  2. The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. (PMID: 9789075) Yang Y.Y. … Darnell R.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 23
  3. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (PMID: 9344654) Fletcher C.F. … Darnell R.B. (Genomics 1997) 2 3
  4. ANOVA, a putative astrocytic RNA binding protein gene that maps to chromosome 19q13.3. (PMID: 10735272) Ueki K. … Louis D.N. (Neurogenetics 1997) 3 23
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for NOVA2 Gene

Sources for NOVA2 Gene