NOVA1 Gene

Aliases
for NOVA1 gene

Previous GC identifers: GC14M024286 GC14M020702 GC14M024905 GC14M025984 GC14M007031

Summaries
for NOVA1 gene

Genomic Views
for NOVA1 gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOVA1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOVA1

NOVA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M026915:  view genomic region     (about GC identifiers)

Proteins
for NOVA1 gene

3 PDB 3D structures from and Proteopedia for NOVA1:

1DT4 (3D)        2ANN (3D)        2ANR (3D)    

Explore the universe of human proteins at neXtProt for NOVA1: NX_P51513

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): NOVA1 OriGene Protein Over-expression Lysate (see all 3): NOVA1 OriGene Custom Protein Services for NOVA1
	GenScript Custom Purified and Recombinant Proteins Services for NOVA1
	Novus Biologicals NOVA1 Proteins Novus Biologicals NOVA1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NOVA1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NOVA1
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): NOVA1 OriGene Custom Antibody Services for NOVA1
	GenScript Custom Superior Antibodies Services for NOVA1
	Novus Biologicals NOVA1 Antibodies
	Abcam antibodies for NOVA1
	Uscn Antibodies for NOVA1
	ThermoFisher Antibody for NOVA1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NOVA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NOVA1

Protein Domains /
Families
for NOVA1 gene

ProtoNet protein and cluster: P51513

Function
for NOVA1 gene

miRNA Products:		miRTarBase miRNAs that target NOVA1: hsa-mir-338-3p (MIRT003039)
		OriGene 3'-UTR Clone (see all 3): NOVA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOVA1
		8/243 QIAGEN miScript miRNA Assays for microRNAs that regulate NOVA1 (see all 243):
		hsa-miR-579 hsa-miR-3938 hsa-miR-640 hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-520f hsa-miR-1914* hsa-miR-146a
		SwitchGear 3'UTR luciferase reporter plasmid: NOVA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOVA1 OriGene shRNA RFP: NOVA1 OriGene siRNA: NOVA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOVA1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NOVA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOVA1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOVA1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NOVA1 (NM_006489)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOVA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOVA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOVA1
		Search LifeMap BioReagents cell lines for NOVA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOVA1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Nova1)

Pathways & Interactions
for NOVA1 gene

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for NOVA1 gene

Transcripts
for NOVA1 gene

Expression
for NOVA1 gene

NOVA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTAGGGCA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
	BrainThalamus			Brain
	Neural TubeDiencephalon			Neural Tube
	Neural TubeTelencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOVA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOVA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOVA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOVA1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOVA1

Orthologs
for NOVA1 gene

Paralogs
for NOVA1 gene

Paralogs for NOVA1 gene

FUBP1²  PCBP4²  HNRNPK²  KHSRP²  PCBP3²  PCBP2²  NOVA2²  PCBP1²  

FUBP3²  

13 SIMAP similar genes for NOVA1 using alignment to 11 protein entries:     NOVA1_HUMAN (see all proteins):

NOVA2    FUBP1    ANKRD17    ANKHD1    DKFZp586G1024    HNRPK

IGF2BP2    KHSRP    FUBP3    TDRKH    PCBP2    PCBP4

PCBP3

NOVA1 for paralogs           About GeneDecksing

Genomic Variants
for NOVA1 gene

10/2222 NCBI SNPs in NOVA1 are shown (see all 2222)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs736038191,2	C,	--	7183991(+)	GCATTC/GGAGTG	2	--	int1		2		WA	120
rs785840581,2	F,	--	7184873(+)	GTTACG/ACAGTT	2	--	int1		1		NA	120
rs761737261,2	C	--	26914721(+)	CATTTA/TCAGCA	2	--	ds5001		0	--	--	--	--
rs776510411,2	C	--	26914722(+)	ATTTTA/CAGCAA	2	--	ds5001		0	--	--	--	--
rs1906173921,2		--	26915034(+)	ATGTAC/TTATAA	2	--	ds5001		0	--	--	--	--
rs58073621,2	C	--	26915364(+)	AAAAA-/ATGAGT	2	--	ut31 trp3		0	--	--	--	--
rs1381372041,2		--	26915399(+)	TTTGAC/TAGAAA	2	--	ut31		0	--	--	--	--
rs1828465491,2		--	26915404(+)	CAGAAA/GTGAAT	2	--	ut31		0	--	--	--	--
rs1876949701,2		--	26915451(+)	TTCAAA/GTTCTC	2	--	ut31		0	--	--	--	--
rs1913627431,2		--	26915572(+)	CTGGAC/TGAAAT	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for NOVA1 (26912299 - 27066960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for NOVA1
     9 CNVs: 76605 76604 5730 87157 76606 87153 76607 87154 76603
     2 Indels: 87158 87156

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOVA1

DNA2.0 Custom Variant and Variant Library Synthesis for NOVA1

Disorders / Diseases
for NOVA1 gene

11 diseases for NOVA1

2 Novoseek disease relationships for NOVA1 gene    About this table

Publications
for NOVA1 gene

PubMed articles for NOVA1 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with NOVA1)

Utopia: connect your pdf to the dynamic world of online information

1. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. (PubMed id 8398153)^{1, 2, 9} Buckanovich R.J.... Darnell R.B. (1993)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. (PubMed id 10368286)^{1, 2} Lewis H.A....Burley S.K. (1999)
4. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PubMed id 8558240)^{1, 3} Buckanovich R.J....Darnell R.B. (1996)
5. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. (PubMed id 9154818)^{1, 9} Buckanovich R.J. and Darnell R.B. (1997)
6. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PubMed id 18218628)^{1, 9} Ratti A....Silani V. (2008)
7. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PubMed id 12808107)^{1, 9} Dredge B.K. and Darnell R.B. (2003)
8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)

External Searches for NOVA1 gene

Genome Databases showing NOVA1 gene

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Specialized Databases showing NOVA1 gene

Products
for NOVA1 gene