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Aliases for NOVA1 Gene

Aliases for NOVA1 Gene

  • Neuro-Oncological Ventral Antigen 1 2 3 4 5
  • Ventral Neuron-Specific Protein 1 3 4
  • Onconeural Ventral Antigen 1 3 4
  • Paraneoplastic Ri Antigen 3 4
  • Nova-1 3

External Ids for NOVA1 Gene

Previous GeneCards Identifiers for NOVA1 Gene

  • GC14M024286
  • GC14M020702
  • GC14M024905
  • GC14M025984
  • GC14M026915
  • GC14M007031

Summaries for NOVA1 Gene

Entrez Gene Summary for NOVA1 Gene

  • This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOVA1 Gene

NOVA1 (Neuro-Oncological Ventral Antigen 1) is a Protein Coding gene. Diseases associated with NOVA1 include Partial Fetal Alcohol Syndrome. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for NOVA1 Gene

  • May regulate RNA splicing or metabolism in a specific subset of developing neurons.

Gene Wiki entry for NOVA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOVA1 Gene

Genomics for NOVA1 Gene

Regulatory Elements for NOVA1 Gene

Enhancers for NOVA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOVA1 on UCSC Golden Path with GeneCards custom track

Promoters for NOVA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOVA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOVA1 Gene

26,443,093 bp from pter
26,597,754 bp from pter
154,662 bases
Minus strand

Genomic View for NOVA1 Gene

Genes around NOVA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOVA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOVA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOVA1 Gene

Proteins for NOVA1 Gene

  • Protein details for NOVA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein Nova-1
    Protein Accession:
    Secondary Accessions:
    • A8K0S4
    • A8K4Q7
    • D3DS81
    • D3DS82
    • Q6B004

    Protein attributes for NOVA1 Gene

    510 amino acids
    Molecular mass:
    52056 Da
    Quaternary structure:
    • Interacts with PTBP2; the interaction is direct.

    Three dimensional structures from OCA and Proteopedia for NOVA1 Gene

    Alternative splice isoforms for NOVA1 Gene


neXtProt entry for NOVA1 Gene

Proteomics data for NOVA1 Gene at MOPED

Post-translational modifications for NOVA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOVA1 Gene

Domains & Families for NOVA1 Gene

Protein Domains for NOVA1 Gene


Suggested Antigen Peptide Sequences for NOVA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 KH domains.
  • Contains 3 KH domains.
genes like me logo Genes that share domains with NOVA1: view

No data available for Gene Families for NOVA1 Gene

Function for NOVA1 Gene

Molecular function for NOVA1 Gene

GENATLAS Biochemistry:
neuro-oncological ventral antigen 1 identified using antisera from patients with breast,and with a paraneoplastic neurologic disorder cancer,involving subcortical motor system characterized by paraneoplastic opsoclonus myoclonus ataxia
UniProtKB/Swiss-Prot Function:
May regulate RNA splicing or metabolism in a specific subset of developing neurons.
genes like me logo Genes that share phenotypes with NOVA1: view

Animal Models for NOVA1 Gene

MGI Knock Outs for NOVA1:

Animal Model Products

miRNA for NOVA1 Gene

miRTarBase miRNAs that target NOVA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOVA1 Gene

Localization for NOVA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOVA1 Gene

Subcellular locations from

Jensen Localization Image for NOVA1 Gene COMPARTMENTS Subcellular localization image for NOVA1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NOVA1 Gene

Pathways & Interactions for NOVA1 Gene

SuperPathways for NOVA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006396 RNA processing TAS 8398153
genes like me logo Genes that share ontologies with NOVA1: view

No data available for Pathways by source and SIGNOR curated interactions for NOVA1 Gene

Drugs & Compounds for NOVA1 Gene

No Compound Related Data Available

Transcripts for NOVA1 Gene

Unigene Clusters for NOVA1 Gene

Neuro-oncological ventral antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOVA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for NOVA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOVA1 Gene

mRNA expression in normal human tissues for NOVA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOVA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6) and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for NOVA1 Gene

This gene is overexpressed in Fetal Brain (43.1) and Frontal cortex (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOVA1 Gene

SOURCE GeneReport for Unigene cluster for NOVA1 Gene Hs.31588

mRNA Expression by UniProt/SwissProt for NOVA1 Gene

Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with NOVA1: view

Protein tissue co-expression partners for NOVA1 Gene

- Elite partner

Orthologs for NOVA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOVA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC490632 35
  • 98.76 (n)
  • 99.79 (a)
NOVA1 36
  • 100 (a)
(Mus musculus)
Mammalia Nova1 35
  • 96.55 (n)
  • 99.59 (a)
Nova1 16
Nova1 36
  • 100 (a)
(Pan troglodytes)
Mammalia NOVA1 35
  • 99.79 (n)
  • 99.79 (a)
NOVA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nova1 35
  • 96.13 (n)
  • 99.59 (a)
(Bos Taurus)
Mammalia NOVA1 36
  • 100 (a)
(Monodelphis domestica)
Mammalia NOVA1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia NOVA1 36
  • 99 (a)
(Gallus gallus)
Aves NOVA1 35
  • 95.38 (n)
  • 99.79 (a)
NOVA1 36
  • 97 (a)
(Anolis carolinensis)
Reptilia NOVA1 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nova1 35
  • 80.19 (n)
  • 97.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53786 35
(Danio rerio)
Actinopterygii nova2 35
  • 70.67 (n)
  • 82.4 (a)
nova2 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta ps 37
  • 39 (a)
ps 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y59A8B.10 36
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BTR1L 35
  • 49.01 (n)
  • 38.15 (a)
(Oryza sativa)
Liliopsida Os02g0822300 35
  • 51.78 (n)
  • 38.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for NOVA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOVA1 Gene

Gene Tree for NOVA1 (if available)
Gene Tree for NOVA1 (if available)

Paralogs for NOVA1 Gene

Paralogs for NOVA1 Gene

genes like me logo Genes that share paralogs with NOVA1: view

Variants for NOVA1 Gene

Sequence variations from dbSNP and Humsavar for NOVA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs15844 -- 26,595,468(+) TGCAA(C/T)TGAAC reference, synonymous-codon, utr-variant-5-prime
rs1273045 -- 26,500,889(-) GATAT(A/C)TTTTT intron-variant
rs178159 -- 26,567,912(-) TGACT(A/G)TAATA intron-variant
rs178160 -- 26,566,908(-) TGTTT(A/G)TCTAA intron-variant
rs178161 -- 26,566,598(-) GTAGG(C/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOVA1 Gene

Variant ID Type Subtype PubMed ID
nsv901522 CNV Loss 21882294
nsv85659 CNV Loss 16902084
esv270930 CNV Insertion 20981092
esv273188 CNV Insertion 20981092

Variation tolerance for NOVA1 Gene

Residual Variation Intolerance Score: 9.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOVA1 Gene

Disorders for NOVA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOVA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NOVA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOVA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NOVA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOVA1 Gene

Publications for NOVA1 Gene

  1. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. (PMID: 8398153) Buckanovich R.J. … Darnell R.B. (Neuron 1993) 3 4 23 67
  2. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PMID: 18218628) Ratti A. … Silani V. (J. Biol. Chem. 2008) 3 23
  3. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PMID: 12808107) Dredge B.K. … Darnell R.B. (Mol. Cell. Biol. 2003) 3 23
  4. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. (PMID: 9154818) Buckanovich R.J. … Darnell R.B. (Mol. Cell. Biol. 1997) 3 23
  5. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PMID: 8558240) Buckanovich R.J. … Darnell R.B. (J. Neurosci. 1996) 2 3

Products for NOVA1 Gene

Sources for NOVA1 Gene