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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOVA1 Gene

protein-coding   GIFtS: 60
GCID: GC14M026915

Neuro-Oncological Ventral Antigen 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuro-Oncological Ventral Antigen 11 2 3
Onconeural Ventral Antigen 12 3
Paraneoplastic Ri Antigen2 3
Ventral Neuron-Specific Protein 12 3
Nova-12
RNA-Binding Protein Nova-12

External Ids:    HGNC: 78861   Entrez Gene: 48572   Ensembl: ENSG000001399107   OMIM: 6021575   UniProtKB: P515133   

Export aliases for NOVA1 gene to outside databases

Previous GC identifers: GC14M024286 GC14M020702 GC14M024905 GC14M025984 GC14M007031


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOVA1 Gene:
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease
antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera
of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively
spliced transcripts encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for NOVA1 Gene: 
NOVA1 (neuro-oncological ventral antigen 1) is a protein-coding gene. Diseases associated with NOVA1 include paraneoplastic neurologic disorders, and neuronitis. GO annotations related to this gene include mRNA binding and RNA binding. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot: NOVA1_HUMAN, P51513
Function: May regulate RNA splicing or metabolism in a specific subset of developing neurons

Gene Wiki entry for NOVA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOVA1 gene promoter:
         LHX3b/Lhx3b   FAC1   NRSF form 1   LHX3a/Lhx3a   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOVA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOVA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOVA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

NOVA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOVA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M026915:  view genomic region     (about GC identifiers)

Start:
26,912,299 bp from pter      End:
27,066,960 bp from pter
Size:
154,662 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOVA1_HUMAN, P51513 (See protein sequence)
Recommended Name: RNA-binding protein Nova-1  
Size: 510 amino acids; 52056 Da
Subunit: Interacts with PTBP2; the interaction is direct (By similarity)
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for NOVA1:
1DT4 (3D)        2ANN (3D)        2ANR (3D)    
Secondary accessions: A8K0S4 A8K4Q7 D3DS81 D3DS82 Q6B004
Alternative splicing: 5 isoforms:  P51513-1   P51513-2   P51513-3   P51513-4   P51513-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for NOVA1: NX_P51513

Explore proteomics data for NOVA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51513

  • NOVA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOVA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002506.2  NP_006480.2  NP_006482.1  

    ENSEMBL proteins: 
     ENSP00000448956   ENSP00000447391   ENSP00000438875   ENSP00000408914   ENSP00000299472  
     ENSP00000448144   ENSP00000449113   ENSP00000449185   ENSP00000342387   ENSP00000448157  
     ENSP00000459545   ENSP00000267422  

    Human Recombinant Protein Products for NOVA1: 
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    OriGene Purified Proteins for NOVA1
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    Novus Biologicals NOVA1 Proteins
    Novus Biologicals NOVA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOVA1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NOVA1 for ontologies           About GeneDecksing



    NOVA1 Antibody Products: 
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    Assay Products for NOVA1: 
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    Cloud-Clone Corp. ELISAs for NOVA1 
    Cloud-Clone Corp. CLIAs for NOVA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry P51513

    ProtoNet protein and cluster: P51513

    1 Blocks protein domain: IPB004087 KH domain

    UniProtKB/Swiss-Prot: NOVA1_HUMAN, P51513
    Similarity: Contains 3 KH domains


    NOVA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOVA1_HUMAN, P51513
    Function: May regulate RNA splicing or metabolism in a specific subset of developing neurons

         Genatlas biochemistry entry for NOVA1:
    neuro-oncological ventral antigen 1 identified using antisera from patients with breast,and with a paraneoplastic
    neurologic disorder cancer,involving subcortical motor system characterized by paraneoplastic opsoclonus
    myoclonus ataxia

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS8558240
    GO:0003729mRNA binding IEA--
         
    NOVA1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nova1):
     behavior/neurological  cellular  growth/size  mortality/aging  nervous system 

    NOVA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOVA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOVA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOVA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOVA1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOVA1:
    hsa-mir-338-3p (MIRT003039)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOVA1
    8/243 QIAGEN miScript miRNA Assays for microRNAs that regulate NOVA1 (see all 243):
    hsa-miR-579 hsa-miR-3938 hsa-miR-640 hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-520f hsa-miR-1914* hsa-miR-146a
    SwitchGear 3'UTR luciferase reporter plasmidNOVA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOVA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOVA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOVA1
    Sirion Biotech Customized adenovirus for overexpression of NOVA1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NOVA1 (see all 17)
    OriGene ORF clones in mouse, rat for NOVA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NOVA1 (NM_006489)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOVA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOVA1
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                         Customized lentivirus expression plasmids for stable overexpression of NOVA1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NOVA1
    Search LifeMap BioReagents cell lines for NOVA1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOVA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOVA1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for NOVA1 (P515132, 3 ENSP000002674224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2861259 MINT-2861278 I2D: score=3 STRING: ENSP00000305556
    SMARCC2Q8TAQ22, 3, ENSP000002670644MINT-64584 I2D: score=4 STRING: ENSP00000267064
    RPP14O950592, 3, ENSP000002959594MINT-8269175 I2D: score=2 STRING: ENSP00000295959
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IEA--
    GO:0006396RNA processing TAS8398153
    GO:0007268synaptic transmission TAS8558240
    GO:0007626locomotory behavior TAS8558240
    GO:0008380RNA splicing TAS8398153

    NOVA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOVA1

    Search CenterWatch for drugs/clinical trials and news about NOVA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOVA1 gene (3 alternative transcripts): 
    NM_002515.2  NM_006489.2  NM_006491.2  

    Unigene Cluster for NOVA1:

    Neuro-oncological ventral antigen 1
    Hs.31588  [show with all ESTs]
    Unigene Representative Sequence: AK226114
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483536 ENST00000465357 ENST00000539517(uc001wpy.3 uc001wpz.3 uc001wqa.3)
    ENST00000449198 ENST00000347476 ENST00000546546 ENST00000549146 ENST00000549571
    ENST00000344429(uc001wqb.3) ENST00000547619 ENST00000574031 ENST00000551754
    ENST00000547415 ENST00000267422

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOVA1
    8/243 QIAGEN miScript miRNA Assays for microRNAs that regulate NOVA1 (see all 243):
    hsa-miR-579 hsa-miR-3938 hsa-miR-640 hsa-miR-361-5p hsa-miR-193a-3p hsa-miR-520f hsa-miR-1914* hsa-miR-146a
    SwitchGear 3'UTR luciferase reporter plasmidNOVA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOVA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOVA1
    Clone
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    OriGene clones in human, mouse for NOVA1 (see all 17)
    OriGene ORF clones in mouse, rat for NOVA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NOVA1 (NM_006489)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOVA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOVA1
    Sirion Biotech Customized lentivirus for stable overexpression of NOVA1 
                         Customized lentivirus expression plasmids for stable overexpression of NOVA1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOVA1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOVA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOVA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOVA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOVA1

    Additional mRNA sequence: 

    AK226114.1 AK289639.1 AK291022.1 AK291468.1 AK301526.1 BC075038.2 BC075039.2 Z70771.1 

    13 DOTS entries:

    DT.207263  DT.408887  DT.100814119  DT.75100057  DT.75158701  DT.97820989  DT.120766333  DT.40264833 
    DT.91746131  DT.99937460  DT.120766304  DT.91676743  DT.99995194 

    24/79 AceView cDNA sequences (see all 79):

    AI082708 BE217956 BF343687 BG056123 AI690262 BC075039 AI569678 BQ694998 
    CR616714 AA861182 AW748796 AI479443 BC075038 BM665241 AI379154 AI339189 
    BF939842 H88536 BX648083 NM_006491 BG150129 BF594200 AW020883 BF196139 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NOVA1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:        -     -                             -     -     -     -     -                                 
    SP2:                                            -     -     -     -     -                                 
    SP3:                                            -           -     -     -           -                     
    SP4:                                            -     -           -     -           -                     
    SP5:                                                  -     -     -                                       


    ECgene alternative splicing isoforms for NOVA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOVA1 expression in normal human tissues (normalized intensities)      NOVA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAGGGCA
    NOVA1 Expression
    About this image


    NOVA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in glomeruli   

    See NOVA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOVA1

    SOURCE GeneReport for Unigene cluster: Hs.31588

    UniProtKB/Swiss-Prot: NOVA1_HUMAN, P51513
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for NOVA1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOVA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOVA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOVA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NOVA1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nova11 , 5 neuro-oncological ventral antigen 11, 5 96.58(n)1
    99.61(a)1
      12 (21.46 cM)5
    6648831  NM_021361.11  NP_067336.11 
     466945175 
    chicken
    (Gallus gallus)
    Aves NOVA11 neuro-oncological ventral antigen 1 95.38(n)
    99.79(a)
      423300  NM_001199713.1  NP_001186642.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOVA16
    Uncharacterized protein
    99(a)
    1 ↔ 1
    1(28875367-29032400)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537862 similar to neuro-oncological ventral antigen 1 74.92(n)    BC046731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nova21 neuro-oncological ventral antigen 2 71.22(n)
    83.44(a)
      553201  XM_003200054.1  XP_003200102.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ps1 , 3 RNA binding3
    pasilla1
    39(a)3
    52.22(n)1
    53.27(a)1
      442581  NM_169281.31  NP_731352.31 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y59A8B.101 Protein Y59A8B.10 46.54(n)
    35.53(a)
      180183  NM_075128.5  NP_507529.1 


    ENSEMBL Gene Tree for NOVA1 (if available)
    TreeFam Gene Tree for NOVA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOVA1 gene
    PCBP22  NOVA22  PCBP42  HNRNPK2  PCBP12  PCBP32  
    13 SIMAP similar genes for NOVA1 using alignment to 10 protein entries:     NOVA1_HUMAN (see all proteins):
    NOVA2    FUBP1    KHSRP    ANKRD17    ANKHD1    DKFZp586G1024
    HNRPK    IGF2BP2    FUBP3    PCBP2    TDRKH    PCBP4
    PCBP3

    NOVA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2714 SNPs in NOVA1 are shown (see all 2714)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877248171,2
    --7183838(+) GCCGTA/GCCAGC 2 -- int10--------
    rs1396729001,2
    --7183958(+) GGAGCC/GGCGAC 2 -- int10--------
    rs736038191,2
    C,F--7183991(+) GCATTC/GGAGTG 2 -- int12Minor allele frequency- G:0.03WA 120
    rs1443349681,2
    --7184083(+) TTAGTA/TTTTAT 2 -- int10--------
    rs1480475751,2
    C--7184290(+) CCCTT-/CACAAG 2 -- int10--------
    rs619880671,2
    C--7184298(+) AAGGCG/TCTGGT 2 -- int13Minor allele frequency- T:0.07NA EA 242
    rs1160901871,2
    C,F--7184332(+) GCTGAG/CTGTGC 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1907557491,2
    --7184345(+) ACAGAA/GCTAAA 2 -- int10--------
    rs1823648741,2
    --7184641(+) CATGGA/GATTCG 2 -- int10--------
    rs619880681,2
    C--7184686(+) AGGCTG/ATTTTA 2 -- int12Minor allele frequency- A:0.06NA 122

    HapMap Linkage Disequilibrium report for NOVA1 (26912299 - 27066960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NOVA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270930CNV Insertion20981092
    esv273188CNV Insertion20981092
    nsv901522CNV Loss21882294
    nsv85659CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602157    OMIM disorders: --

    8 diseases for NOVA1:    About MalaCards
    paraneoplastic neurologic disorders    neuronitis    lung cancer    myoclonus
    ataxia    breast cancer    dementia    schizophrenia


    NOVA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for NOVA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    opsoclonus 90.6 1 11784037 (1)
    tumors 0 1 10735272 (1)

    Genetic Association Database (GAD): NOVA1
    Human Genome Epidemiology (HuGE) Navigator: NOVA1 (2 documents)

    Export disorders for NOVA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOVA1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with NOVA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. (PubMed id 8398153)1, 2, 9 Buckanovich R.J.... Darnell R.B. (1993)
    2. Genome-wide association study of antipsychotic-induce d parkinsonism severity among schizophrenia patients. (PubMed id 19680635)1, 4 Alkelai A....Lerer B. (2009)
    3. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains. (PubMed id 10368286)1, 2 Lewis H.A....Burley S.K. (1999)
    6. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PubMed id 8558240)1, 3 Buckanovich R.J....Darnell R.B. (1996)
    7. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. (PubMed id 9154818)1, 9 Buckanovich R.J. and Darnell R.B. (1997)
    8. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PubMed id 18218628)1, 9 Ratti A....Silani V. (2008)
    9. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PubMed id 12808107)1, 9 Dredge B.K. and Darnell R.B. (2003)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4857 HGNC: 7886 AceView: NOVA1 Ensembl:ENSG00000139910 euGenes: HUgn4857
    ECgene: NOVA1 H-InvDB: NOVA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOVA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOVA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOVA1 gene:
    Search GeneIP for patents involving NOVA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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