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Aliases for NOVA1 Gene

Aliases for NOVA1 Gene

  • Neuro-Oncological Ventral Antigen 1 2 3 4
  • Ventral Neuron-Specific Protein 1 3 4
  • Onconeural Ventral Antigen 1 3 4
  • Paraneoplastic Ri Antigen 3 4
  • RNA-Binding Protein Nova-1 3
  • Nova-1 3

External Ids for NOVA1 Gene

Previous GeneCards Identifiers for NOVA1 Gene

  • GC14M024286
  • GC14M020702
  • GC14M024905
  • GC14M025984
  • GC14M026915
  • GC14M007031

Summaries for NOVA1 Gene

Entrez Gene Summary for NOVA1 Gene

  • This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOVA1 Gene

NOVA1 (Neuro-Oncological Ventral Antigen 1) is a Protein Coding gene. Diseases associated with NOVA1 include paraneoplastic neurologic disorders and lung cancer. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is PCBP3.

UniProtKB/Swiss-Prot for NOVA1 Gene

  • May regulate RNA splicing or metabolism in a specific subset of developing neurons

Gene Wiki entry for NOVA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOVA1 Gene

Genomics for NOVA1 Gene

Regulatory Elements for NOVA1 Gene

Genomic Location for NOVA1 Gene

Start:
26,443,093 bp from pter
End:
26,598,027 bp from pter
Size:
154,935 bases
Orientation:
Minus strand

Genomic View for NOVA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOVA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOVA1 Gene

Proteins for NOVA1 Gene

  • Protein details for NOVA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51513-NOVA1_HUMAN
    Recommended name:
    RNA-binding protein Nova-1
    Protein Accession:
    P51513
    Secondary Accessions:
    • A8K0S4
    • A8K4Q7
    • D3DS81
    • D3DS82
    • Q6B004

    Protein attributes for NOVA1 Gene

    Size:
    510 amino acids
    Molecular mass:
    52056 Da
    Quaternary structure:
    • Interacts with PTBP2; the interaction is direct.

    Three dimensional structures from OCA and Proteopedia for NOVA1 Gene

    Alternative splice isoforms for NOVA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOVA1 Gene

Proteomics data for NOVA1 Gene at MOPED

Post-translational modifications for NOVA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NOVA1 Gene

Domains for NOVA1 Gene

Protein Domains for NOVA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOVA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51513

UniProtKB/Swiss-Prot:

NOVA1_HUMAN :
  • P51513
Domain:
  • Contains 3 KH domains.
genes like me logo Genes that share domains with NOVA1: view

No data available for Gene Families for NOVA1 Gene

Function for NOVA1 Gene

Molecular function for NOVA1 Gene

GENATLAS Biochemistry:
neuro-oncological ventral antigen 1 identified using antisera from patients with breast,and with a paraneoplastic neurologic disorder cancer,involving subcortical motor system characterized by paraneoplastic opsoclonus myoclonus ataxia
UniProtKB/Swiss-Prot Function:
May regulate RNA splicing or metabolism in a specific subset of developing neurons

Gene Ontology (GO) - Molecular Function for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 8558240
GO:0003729 mRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NOVA1: view
genes like me logo Genes that share phenotypes with NOVA1: view

Animal Model Products

miRNA for NOVA1 Gene

miRTarBase miRNAs that target NOVA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOVA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOVA1 Gene

Localization for NOVA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOVA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOVA1 Gene COMPARTMENTS Subcellular localization image for NOVA1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOVA1: view

Pathways for NOVA1 Gene

SuperPathways for NOVA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006396 RNA processing TAS 8398153
GO:0007268 synaptic transmission TAS 8558240
GO:0007626 locomotory behavior TAS 8558240
GO:0008380 RNA splicing TAS 8398153
genes like me logo Genes that share ontologies with NOVA1: view

No data available for Pathways by source for NOVA1 Gene

Transcripts for NOVA1 Gene

Unigene Clusters for NOVA1 Gene

Neuro-oncological ventral antigen 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOVA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOVA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for NOVA1 Gene

GeneLoc Exon Structure for
NOVA1
ECgene alternative splicing isoforms for
NOVA1

Expression for NOVA1 Gene

mRNA expression in normal human tissues for NOVA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOVA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.6) and Brain - Cerebellum (4.1).

Protein differential expression in normal tissues for NOVA1 Gene

This gene is overexpressed in Fetal Brain (43.1) and Frontal cortex (21.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOVA1 Gene

SOURCE GeneReport for Unigene cluster for NOVA1 Gene Hs.31588

mRNA Expression by UniProt/SwissProt for NOVA1 Gene

P51513-NOVA1_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with NOVA1: view

Expression partners for NOVA1 Gene

In Situ Assay Products

Orthologs for NOVA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOVA1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC490632 35
  • 98.76 (n)
  • 99.79 (a)
NOVA1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nova1 35
  • 96.55 (n)
  • 99.59 (a)
Nova1 16
Nova1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOVA1 35
  • 99.79 (n)
  • 99.79 (a)
NOVA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nova1 35
  • 96.13 (n)
  • 99.59 (a)
cow
(Bos Taurus)
Mammalia NOVA1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOVA1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOVA1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOVA1 35
  • 95.38 (n)
  • 99.79 (a)
NOVA1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOVA1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nova1 35
  • 80.19 (n)
  • 97.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53786 35
zebrafish
(Danio rerio)
Actinopterygii nova2 35
  • 70.67 (n)
  • 82.4 (a)
nova2 36
  • 78 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ps 37
  • 39 (a)
ps 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y59A8B.10 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BTR1L 35
  • 49.01 (n)
  • 38.15 (a)
rice
(Oryza sativa)
Liliopsida Os02g0822300 35
  • 51.78 (n)
  • 38.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for NOVA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOVA1 Gene

ENSEMBL:
Gene Tree for NOVA1 (if available)
TreeFam:
Gene Tree for NOVA1 (if available)

Paralogs for NOVA1 Gene

Paralogs for NOVA1 Gene

genes like me logo Genes that share paralogs with NOVA1: view

Variants for NOVA1 Gene

Sequence variations from dbSNP and Humsavar for NOVA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15844 -- 26,595,468(+) TGCAA(C/T)TGAAC synonymous-codon, reference, utr-variant-5-prime
rs178159 -- 26,567,912(-) TGACT(A/G)TAATA intron-variant
rs178160 -- 26,566,908(-) TGTTT(A/G)TCTAA intron-variant
rs178161 -- 26,566,598(-) GTAGG(C/G)TAATA intron-variant
rs178162 -- 26,564,807(-) ACATA(G/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOVA1 Gene

Variant ID Type Subtype PubMed ID
nsv901522 CNV Loss 21882294
nsv85659 CNV Loss 16902084
esv270930 CNV Insertion 20981092
esv273188 CNV Insertion 20981092

Relevant External Links for NOVA1 Gene

HapMap Linkage Disequilibrium report
NOVA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOVA1 Gene

Disorders for NOVA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NOVA1 Gene in MalaCards »

(3) Diseases for NOVA1 Gene including...

(2) Novoseek inferred disease relationships for NOVA1 Gene

Disease -log(P) Hits PubMed IDs
opsoclonus 90.6 1
tumors 0 1

Relevant External Links for NOVA1

Genetic Association Database (GAD)
NOVA1
Human Genome Epidemiology (HuGE) Navigator
NOVA1
genes like me logo Genes that share disorders with NOVA1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NOVA1 Gene

Publications for NOVA1 Gene

  1. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. (PMID: 8398153) Buckanovich R.J. … Darnell R.B. (Neuron 1993) 3 4 23
  2. The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. (PMID: 9154818) Buckanovich R.J. … Darnell R.B. (Mol. Cell. Biol. 1997) 3 23
  3. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PMID: 12808107) Dredge B.K. … Darnell R.B. (Mol. Cell. Biol. 2003) 3 23
  4. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PMID: 18218628) Ratti A. … Silani V. (J. Biol. Chem. 2008) 3 23
  5. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PMID: 8558240) Buckanovich R.J. … Darnell R.B. (J. Neurosci. 1996) 2 3

Products for NOVA1 Gene

  • Addgene plasmids for NOVA1

Sources for NOVA1 Gene

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