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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOV Gene

protein-coding   GIFtS: 60
GCID: GC08P120428

nephroblastoma overexpressed

(Previous name: nephroblastoma overexpressed gene )
 Explore 28 diseases affiliated with
NOV via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NOV    

Aliases
for NOV gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nephroblastoma Overexpressed1 2     CCN Family Member 32 3
CCN31 2 3     IGF-Binding Protein 92 3
IGFBP91 2 3     Nephroblastoma Overexpressed Gene1
Insulin-Like Growth Factor-Binding Protein 92 3     NOVh2
Nephroblastoma-Overexpressed Gene Protein Homolog2 3     Protein NOV Homolog2
IBP-92 3     NOVH3
IGFBP-92 3     NovH3

External Ids:    HGNC: 78851   Entrez Gene: 48562   Ensembl: ENSG000001369997   OMIM: 1649585   UniProtKB: P487453   

Export aliases for NOV gene to outside databases

Previous GC identifers: GC08P119415 GC08P120434 GC08P120097 GC08P120385 GC08P120497 GC08P115749


Summaries
for NOV gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NOV:
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory
proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and
skeletal development, fibrosis and cancer development. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)

Gene Wiki entry for NOV


Genomic Views
for NOV gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOV gene promoter:
         c-Fos   AP-1   ATF-2   MyoD   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOV promoter sequence
   Search SABiosciences Chromatin IP Primers for NOV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.1   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

NOV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOV gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120428:  view genomic region     (about GC identifiers)

Start:
 120,428,546 bp from pter      End:
 120,436,678 bp from pter
Size:
 8,133 bases      Orientation:
 plus strand

Proteins
for NOV gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NOV_HUMAN, P48745 (See protein sequence)
Recommended Name: Protein NOV homolog precursor  
Size: 357 amino acids; 39162 Da
Subunit: Interacts with FBLN1
Subcellular location: Secreted
Secondary accessions: B2R5X7 Q6I9S3 Q96BY5 Q9UDE4

Explore the universe of human proteins at neXtProt for NOV: NX_P48745

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48745

    • NOV Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002505.1  
    ENSEMBL proteins: 
     ENSP00000259526  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for NOV (NOV/CCN3)
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    OriGene Protein Over-expression Lysate: NOV
    OriGene Custom Protein Services for NOV 
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    Novus Biologicals NOV Proteins
    Novus Biologicals NOV Lysates
    Sino Biological Recombinant Protein for NOV
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NOV

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--
    GO:0031012extracellular matrix IEA--
    GO:0043025neuronal cell body IEA--


    NOV for ontologies           About GeneDecksing



    NOV Antibody Products: 
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    Uscn ELISAs and CLIAs for NOV

    Protein Domains /
    Families
    for NOV gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOV for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR017891 Insulin_GF-bd_Cys-rich_CS
     IPR006207 Cys_knot_C
     IPR001007 VWF_C
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P48745

    ProtoNet protein and cluster: P48745

    5 Blocks protein families:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    Function
    for NOV gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)
    Induction: Expression is down-regulated by WT1

         Genatlas biochemistry entry for NOV:
    nephroblastoma overexpressed gene homolog (immediate early response gene),

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NOV
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOV
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmid: NOV 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOV (see all 7)
    OriGene shRNA RFP: NOV
    OriGene siRNA: NOV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOV

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NOV

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOV (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOV (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NOV (NM_002514)
    Sino Biological Human cDNA Clone for NOV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOV 

    Cell Line
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    Search LifeMap BioReagents cell lines for NOV

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--


    NOV for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NOV: Novtm1Cabo Novtm1Hko
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nov) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  renal/urinary system  skeleton 

    NOV for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NOV gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adhesion
    		Adhesion1.00
    2Signaling in Gap Junctions
    		Signaling in Gap Junctions1.00
    3Notch Signaling Pathway
    		Delta-Notch Signaling Pathway0.27

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NOV
        Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for NOV
        Adhesion

    1 BioSystems Pathway for NOV 
        Delta-Notch Signaling Pathway



    NOV for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for NOV (P487453 ENSP000002595264) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    GJA1P173023, ENSP000002825614I2D: score=1 STRING: ENSP00000282561
    IGF2P013443, ENSP000003382974I2D: score=1 STRING: ENSP00000338297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0010468regulation of gene expression IEA--


    NOV for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOV gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOV for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOV

    2 DrugBank Compounds for NOV    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--8622864 12149257 17016423 17139284 10084601
    Insulin recombinant-- 9004-10-8target--17139284 17016423

    2 Novoseek chemical compound relationships for NOV gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 32.7 1 12050162 (1)
    heparin 6.61 1 11584015 (1)

    Search CenterWatch for drugs/clinical trials and news about NOV 

    Transcripts
    for NOV gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOV gene: 
    NM_002514.3  

    Unigene Cluster for NOV:

    Nephroblastoma overexpressed
    Hs.235935  [show with all ESTs]
    Unigene Representative Sequence: NM_002514
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259526(uc003yoq.2) ENST00000520082

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOV
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmid: NOV 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOV (see all 7)
    OriGene shRNA RFP: NOV
    OriGene siRNA: NOV
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOV
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOV (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOV (see all 2)
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    GenScript: all cDNA clones in your preferred vector: NOV (NM_002514)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOV 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOV
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOV

    Additional cDNA sequence: 

    AK294289.1 AK312355.1 AY082381.1 BC015028.1 CR457432.1 X96584.1 

    4 DOTS entries:

    DT.114995  DT.100814969  DT.95267727  DT.100829939 

    24/121 AceView cDNA sequences (see all 121):

    AI440024 BQ774547 AA687861 BM984571 CR623165 CA449356 CA447986 BC015028 
    BF440025 D63128 BI850600 AI920781 AI925049 CA449602 AI783828 BX477828 
    CD107552 AW591335 BU188978 AY082381 AL556435 BI491099 BG105327 CR591257 

    GeneLoc Exon Structure


    Expression
    for NOV gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCTGGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NOV expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalic Floor PlateEarly Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Floor PlateLate Floor Plate CellsNeural Ectoderm
    PlacentaChorionic VillusVillous Stromal CellsExtraembryonic Tissues, Placenta
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See NOV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOV

    SOURCE GeneReport for Unigene cluster: Hs.235935

    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of
    the stromal type

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOV: 
              Estrogen Receptor Signaling in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOV
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV

    Orthologs
    for NOV gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NOV gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NOV1 nephroblastoma overexpressed gene 70.66(n)
    69.59(a)    		   396204  NM_205268.1  NP_990599.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NOV6
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343269.1(903375-926561)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nov-A2 nephroblastoma overexpressed gene 72.2(n)    U37063.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ccn6
    		 Ccn
    		 16(a)
    		 1 → many
    		 3L(17683115-17741939)


    ENSEMBL Gene Tree for NOV (if available)
    TreeFam Gene Tree for NOV (if available) 

    Paralogs
    for NOV gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOV gene
    WISP22  CTGF2  WISP32  CYR612  WISP12  
    6 SIMAP similar genes for NOV using alignment to 2 protein entries:     NOV_HUMAN (see all proteins):
    CTGF    WISP2    WISP1    CYR61    LIBC    WISP3

    NOV for paralogs           About GeneDecksing



    Genomic Variants
    for NOV gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/218 NCBI SNPs in NOV are shown (see all 218)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs585768061,2
    		C,F,--115747133(+) CCCACT/ACTTTC 1 -- us2k14Minor allele frequency- A:0.26WA NA 242
    rs105053551,2
    		C,F,H,--115747190(+) TATCTG/CAGTCT 1 -- us2k1106Minor allele frequency- C:0.11NS NA EA PA EU CA WA 6688
    rs168925111,2
    		C,F,--115747419(+) TGGCTT/CACAAA 1 -- us2k17Minor allele frequency- C:0.22NA WA 376
    rs168925121,2
    		C,F,H,--115747787(+) CTGCCG/AAGAGA 1 -- us2k121Minor allele frequency- A:0.06NA NS EA WA 2452
    rs13813331,2
    		C,F,A,H,--115748113(+) TGCTCC/TCTTTT 1 -- us2k1 trp37Minor allele frequency- T:0.20EA NS WA NA 536
    rs13813341,2
    		C,F,A,H,--115748120(+) TTTTTC/GCCATG 1 -- us2k1 trp38Minor allele frequency- G:0.18NS EA WA NA 660
    rs779771531,2
    		C,F,--115748142(+) GCATGC/TCCCAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs13813351,2
    		C,F,O,A,H,--115748165(+) GAAAGC/TGGATG 1 -- us2k1112Minor allele frequency- T:0.11EA NA NS PA EU CA WA 6998
    rs41238371,2
    		C,F,H,--115748373(+) TCTTCT/CGCCAA 1 -- us2k129Minor allele frequency- C:0.19NS EA NA WA 3036
    rs747812411,2
    		F,--115748680(+) CTCCCC/GTCCCT 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for NOV (120428546 - 120436678 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NOV: --

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    Disorders / Diseases
    for NOV gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NOV for disorders           About GeneDecksing

    OMIM gene information: 164958    OMIM disorders: --

    20/28 diseases for NOV (see all 28):    About MalaCards
    nephroblastoma    fibrosis    pre-eclampsia    gastroenteritis
    alveolar rhabdomyosarcoma    wilms tumor    marfan syndrome    rhabdomyosarcoma
    adrenocortical tumor    hepatitis a    renal cell carcinoma    eclampsia
    neurofibromatosis    diarrhea    chondrosarcoma    breast cancer
    glioblastoma    choriocarcinoma    hepatocellular carcinoma    ovarian carcinoma

    1 disease from the University of Copenhagen DISEASES database for NOV:
    Nephroblastoma

    8 Novoseek disease relationships for NOV gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 83.8 60 9626060 (8), 7520150 (4), 9207876 (2), 15345329 (2) (see all 23)
    glioblastoma 29.4 9 14519668 (3), 12147716 (1), 9536281 (1)
    rhabdomyosarcoma 26.3 2 14996733 (1), 11891184 (1)
    glioma 25.2 27 11577170 (6), 18004727 (2), 15041728 (2), 15213231 (1)
    tumors 24.5 20 11891184 (3), 7520150 (2), 11751417 (2), 18418052 (2) (see all 10)
    breast cancer 0 4 19706598 (2)
    metastasis 0 4 11891184 (2), 15526358 (1)
    cancer 0 6 10474687 (2), 11477145 (1)

    Human Genome Epidemiology (HuGE) Navigator: NOV (8 documents)

    Export disorders for NOV gene to outside databases

    Publications
    for NOV gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOV gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with NOV)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of nov by WT1: a potential role for nov in nephrogenesis. (PubMed id 8622864)1, 2, 7, 9 Martinerie C.... Perbal B. (1996)
    2. Structural analysis of the human nov proto-oncogene and expression in Wilms tumor. (PubMed id 7520150)1, 2, 9 Martinerie C.... Perbal B. (1994)
    3. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PubMed id 9927660)1, 2, 9 Perbal B.... Roizman B. (1999)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily. (PubMed id 10084601)1, 7 Burren C.P....Rosenfeld R.G. (1999)
    7. Physical mapping of human loci homologous to the chicken nov proto-oncogene. (PubMed id 1334251)1, 3 Martinerie C....Perbal B. (1992)
    8. Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression. (PubMed id 10474687)1, 9 Perbal B. (1999)
    9. Matricellular protein CCN3 (NOV) regulates actin cyto skeleton reorganization. (PubMed id 19706598)1, 9 Sin W.C....Naus C.C. (2009)
    10. A role for CCN3 (NOV) in calcium signalling. (PubMed id 12147716)1, 9 Li C.L....Perbal B. (2002)

    External Searches for NOV gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOV gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4856 HGNC: 7885 AceView: NOV Ensembl:ENSG00000136999 euGenes: HUgn4856
    ECgene: NOV H-InvDB: NOV

    Other Databases showing NOV gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOV gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOV Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOV Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NOV gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOV gene:
    Search GeneIP for patents involving NOV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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