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Aliases for NOV Gene

Aliases for NOV Gene

  • Nephroblastoma Overexpressed 2 3 5
  • Nephroblastoma-Overexpressed Gene Protein Homolog 3 4
  • Insulin-Like Growth Factor-Binding Protein 9 3 4
  • IGF-Binding Protein 9 3 4
  • CCN Family Member 3 3 4
  • IGFBP-9 3 4
  • IGFBP9 3 4
  • IBP-9 3 4
  • NOVh 3 4
  • CCN3 3 4
  • Nephroblastoma Overexpressed Gene 2
  • Protein NOV Homolog 3

External Ids for NOV Gene

Previous GeneCards Identifiers for NOV Gene

  • GC08P120434
  • GC08P120097
  • GC08P120385
  • GC08P120497
  • GC08P115749
  • GC08P120428

Summaries for NOV Gene

Entrez Gene Summary for NOV Gene

  • The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

GeneCards Summary for NOV Gene

NOV (Nephroblastoma Overexpressed) is a Protein Coding gene. Diseases associated with NOV include Wilms Tumor Susceptibility-5. Among its related pathways are Signaling in Gap Junctions and Adhesion. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is CTGF.

UniProtKB/Swiss-Prot for NOV Gene

  • Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).

Gene Wiki entry for NOV Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOV Gene

Genomics for NOV Gene

Regulatory Elements for NOV Gene

Enhancers for NOV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOV on UCSC Golden Path with GeneCards custom track

Promoters for NOV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NOV Gene

Chromosome:
8
Start:
119,416,306 bp from pter
End:
119,424,438 bp from pter
Size:
8,133 bases
Orientation:
Plus strand

Genomic View for NOV Gene

Genes around NOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOV Gene

Proteins for NOV Gene

  • Protein details for NOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48745-NOV_HUMAN
    Recommended name:
    Protein NOV homolog
    Protein Accession:
    P48745
    Secondary Accessions:
    • B2R5X7
    • Q6I9S3
    • Q96BY5
    • Q9UDE4

    Protein attributes for NOV Gene

    Size:
    357 amino acids
    Molecular mass:
    39162 Da
    Quaternary structure:
    • Interacts with FBLN1. Interacts (via CTCK domain) with NOTCH1 (via the EGF-like repeat region) (PubMed:12050162). Interacts with GJA1/CX43 (PubMed:15181016, PubMed:15213231). Interacts with ITGA5:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:12695522, PubMed:15611078).

neXtProt entry for NOV Gene

Post-translational modifications for NOV Gene

  • Glycosylation at Thr 46, Thr 49, Asn 97, Asn 280, and Thr 353
  • Modification sites at PhosphoSitePlus

Other Protein References for NOV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOV Gene

Domains & Families for NOV Gene

Gene Families for NOV Gene

Suggested Antigen Peptide Sequences for NOV Gene

Graphical View of Domain Structure for InterPro Entry

P48745

UniProtKB/Swiss-Prot:

NOV_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the CCN family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with NOV: view

Function for NOV Gene

Molecular function for NOV Gene

GENATLAS Biochemistry:
nephroblastoma overexpressed gene homolog (immediate early response gene),
UniProtKB/Swiss-Prot Function:
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891).
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by WT1. Expression is down-regulated by proinflammatory stimuli such as TNF or IL1B (PubMed:24722330, PubMed:21063504). Expression is induced by laminar shear stress and statins (PubMed:21063504).

Gene Ontology (GO) - Molecular Function for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 12050162
GO:0005178 integrin binding IPI 12695522
GO:0005515 protein binding IPI 9927660
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with NOV: view
genes like me logo Genes that share phenotypes with NOV: view

Animal Models for NOV Gene

MGI Knock Outs for NOV:

Animal Model Products

  • Taconic Biosciences Mouse Models for NOV

CRISPR Products

miRNA for NOV Gene

miRTarBase miRNAs that target NOV

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOV Gene

Localization for NOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOV Gene

Secreted. Cytoplasm. Cell junction, gap junction. Note=Localizes at the Gap junction in presence of GJA1/CX43. {ECO:0000250 UniProtKB:Q9QZQ5}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOV Gene COMPARTMENTS Subcellular localization image for NOV gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,ISS --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005737 cytoplasm IEA,ISS --
GO:0005921 gap junction IEA,ISS --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NOV: view

Pathways & Interactions for NOV Gene

genes like me logo Genes that share pathways with NOV: view

Pathways by source for NOV Gene

1 Cell Signaling Technology pathway for NOV Gene
1 BioSystems pathway for NOV Gene
1 R&D Systems pathway for NOV Gene
1 Qiagen pathway for NOV Gene

Gene Ontology (GO) - Biological Process for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 12695522
GO:0002062 chondrocyte differentiation IEA,IMP 21871891
GO:0007267 cell-cell signaling IBA --
GO:0010468 regulation of gene expression IEA --
GO:0010761 fibroblast migration IDA 15611078
genes like me logo Genes that share ontologies with NOV: view

No data available for SIGNOR curated interactions for NOV Gene

Drugs & Compounds for NOV Gene

(4) Drugs for NOV Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Human Approved, Investigational Pharma Target 0
Insulin Pork Approved Pharma Target 0
genes like me logo Genes that share compounds with NOV: view

Transcripts for NOV Gene

mRNA/cDNA for NOV Gene

Unigene Clusters for NOV Gene

Nephroblastoma overexpressed:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOV Gene

No ASD Table

Relevant External Links for NOV Gene

GeneLoc Exon Structure for
NOV
ECgene alternative splicing isoforms for
NOV

Expression for NOV Gene

mRNA expression in normal human tissues for NOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOV Gene

This gene is overexpressed in Adrenal Gland (x14.4), Artery - Aorta (x12.4), Artery - Tibial (x8.5), and Artery - Coronary (x8.0).

Protein differential expression in normal tissues from HIPED for NOV Gene

This gene is overexpressed in Urine (23.2), Cerebral cortex (15.2), Amniocyte (11.9), Adrenal (10.9), and Cerebrospinal fluid (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOV Gene



Protein tissue co-expression partners for NOV Gene

NURSA nuclear receptor signaling pathways regulating expression of NOV Gene:

NOV

SOURCE GeneReport for Unigene cluster for NOV Gene:

Hs.235935

mRNA Expression by UniProt/SwissProt for NOV Gene:

P48745-NOV_HUMAN
Tissue specificity: Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
genes like me logo Genes that share expression patterns with NOV: view

Primer Products

Orthologs for NOV Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOV Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOV 34
  • 84.44 (n)
  • 80.87 (a)
NOV 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOV 34
  • 84.23 (n)
  • 81.3 (a)
NOV 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nov 34
  • 82.57 (n)
  • 81.71 (a)
Nov 16
Nov 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOV 34
  • 99.72 (n)
  • 99.16 (a)
NOV 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nov 34
  • 83.62 (n)
  • 81.71 (a)
oppossum
(Monodelphis domestica)
Mammalia NOV 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOV 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOV 34
  • 71.86 (n)
  • 71.65 (a)
NOV 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOV 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nov 34
  • 68.92 (n)
  • 63.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia nov-A 34
zebrafish
(Danio rerio)
Actinopterygii ctgfb 35
  • 47 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for NOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOV Gene

ENSEMBL:
Gene Tree for NOV (if available)
TreeFam:
Gene Tree for NOV (if available)

Paralogs for NOV Gene

Paralogs for NOV Gene

(6) SIMAP similar genes for NOV Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOV: view

Variants for NOV Gene

Sequence variations from dbSNP and Humsavar for NOV Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2279112 - 119,416,784(+) GGGCC(A/C/G)GTGCC reference, missense
rs11538929 - 119,419,266(+) GAACC(A/G)TCAAT reference, missense
rs1057722 -- 119,423,722(+) GTTGT(A/T)TCTAC utr-variant-3-prime
rs1057732 -- 119,424,178(+) TCTGG(C/T)TTGTC utr-variant-3-prime
rs1381333 -- 119,415,356(+) TGCTC(C/T)CTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NOV Gene

Variant ID Type Subtype PubMed ID
nsv1026655 CNV gain 25217958
nsv521624 CNV loss 19592680
nsv527032 CNV loss 19592680

Variation tolerance for NOV Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.45; 85.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOV Gene

Human Gene Mutation Database (HGMD)
NOV
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOV Gene

Disorders for NOV Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOV Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search NOV in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOV

Genetic Association Database (GAD)
NOV
Human Genome Epidemiology (HuGE) Navigator
NOV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOV
genes like me logo Genes that share disorders with NOV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOV Gene

Publications for NOV Gene

  1. NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. (PMID: 17463287) Gupta R. … Enver T. (Science 2007) 3 4 22 65
  2. Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. (PMID: 15181016) Gellhaus A. … Winterhager E. (J. Biol. Chem. 2004) 3 4 22 65
  3. CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. (PMID: 15213231) Fu C.T. … Naus C.C. (J. Biol. Chem. 2004) 3 4 22 65
  4. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. (PMID: 12050162) Sakamoto K. … Katsube K. (J. Biol. Chem. 2002) 3 4 22 65
  5. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PMID: 9927660) Perbal B. … Roizman B. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 22 65

Products for NOV Gene

Sources for NOV Gene

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