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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOV Gene

protein-coding   GIFtS: 62
GCID: GC08P120428

Nephroblastoma Overexpressed

(Previous name: nephroblastoma overexpressed gene)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nephroblastoma Overexpressed1 2     CCN Family Member 32 3
Insulin-Like Growth Factor-Binding Protein 92 3     IGF-Binding Protein 92 3
Nephroblastoma-Overexpressed Gene Protein Homolog2 3     Nephroblastoma Overexpressed Gene1
CCN32 3     NOVh2
IBP-92 3     Protein NOV Homolog2
IGFBP-92 3     NOVH3
IGFBP92 3     NovH3

External Ids:    HGNC: 78851   Entrez Gene: 48562   Ensembl: ENSG000001369997   OMIM: 1649585   UniProtKB: P487453   

Export aliases for NOV gene to outside databases

Previous GC identifers: GC08P119415 GC08P120434 GC08P120097 GC08P120385 GC08P120497 GC08P115749


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOV Gene:
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of
regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in
cardiovascular and skeletal development, fibrosis and cancer development. (provided by RefSeq, Feb 2009)

GeneCards Summary for NOV Gene: 
NOV (nephroblastoma overexpressed) is a protein-coding gene. Diseases associated with NOV include autism spectrum disorder, and nephroblastoma, and among its related super-pathways are Notch signaling pathway and Gap junction. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)

Gene Wiki entry for NOV Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOV gene promoter:
         c-Fos   AP-1   ATF-2   MyoD   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOV promoter sequence
   Search SABiosciences Chromatin IP Primers for NOV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.1   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

NOV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOV gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120428:  view genomic region     (about GC identifiers)

Start:
120,428,546 bp from pter      End:
120,436,678 bp from pter
Size:
8,133 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOV_HUMAN, P48745 (See protein sequence)
Recommended Name: Protein NOV homolog precursor  
Size: 357 amino acids; 39162 Da
Subunit: Interacts with FBLN1
Subcellular location: Secreted
Secondary accessions: B2R5X7 Q6I9S3 Q96BY5 Q9UDE4

Explore the universe of human proteins at neXtProt for NOV: NX_P48745

Explore proteomics data for NOV at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48745

  • NOV Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOV Protein Expression
    REFSEQ proteins: NP_002505.1  
    ENSEMBL proteins: 
     ENSP00000259526  

    Human Recombinant Protein Products for NOV: 
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    OriGene Protein Over-expression Lysate for NOV
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    Novus Biologicals NOV Proteins
    Novus Biologicals NOV Lysates
    Sino Biological Recombinant Protein for NOV
    Sino Biological Cell Lysate for NOV 
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    Cloud-Clone Corp. Proteins for NOV 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--
    GO:0031012extracellular matrix IEA--
    GO:0043025neuronal cell body IEA--

    NOV for ontologies           About GeneDecksing



    NOV Antibody Products: 
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    Cloud-Clone Corp. ELISAs for NOV 
    Cloud-Clone Corp. CLIAs for NOV


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P48745

    ProtoNet protein and cluster: P48745

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    NOV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOV_HUMAN, P48745
    Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)
    Induction: Expression is down-regulated by WT1

         Genatlas biochemistry entry for NOV:
    nephroblastoma overexpressed gene homolog (immediate early response gene),

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    NOV for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nov) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  renal/urinary system  skeleton 

    NOV for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOV: Novtm1Cabo Novtm1Hko

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOV 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOV 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOV 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOV
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidNOV 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOV About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    2Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    3Notch Signaling Pathways
    Notch Signaling Pathways
    4Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOV
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NOV
        Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for NOV
        Adhesion

    1 BioSystems Pathway for NOV
        Delta-Notch Signaling Pathway




    NOV for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for NOV (P487453 ENSP000002595264) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    GJA1P173023, ENSP000002825614I2D: score=1 STRING: ENSP00000282561
    IGF2P013443, ENSP000003382974I2D: score=1 STRING: ENSP00000338297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0010468regulation of gene expression IEA--

    NOV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOV for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOV

    2 DrugBank Compounds for NOV    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--8622864 12149257 17016423 17139284 10084601
    Insulin Regular -- 11061-68-0target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for NOV gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 32.7 1 12050162 (1)
    heparin 6.61 1 11584015 (1)

    Search CenterWatch for drugs/clinical trials and news about NOV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOV gene: 
    NM_002514.3  

    Unigene Cluster for NOV:

    Nephroblastoma overexpressed
    Hs.235935  [show with all ESTs]
    Unigene Representative Sequence: NM_002514
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259526(uc003yoq.2) ENST00000520082
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidNOV 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK294289.1 AK312355.1 AY082381.1 BC015028.1 CR457432.1 X96584.1 

    4 DOTS entries:

    DT.114995  DT.100814969  DT.95267727  DT.100829939 

    24/121 AceView cDNA sequences (see all 121):

    AA298840 BG105327 NM_002514 AI440024 CA447986 D63128 BC015028 BU188978 
    CR591257 CR623165 CA449602 AI923336 AI925049 BI850600 BI491099 CA449356 
    AW591335 CD107552 BX477828 BM984571 AV710966 BF440025 BQ774547 AI783828 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOV expression in normal human tissues (normalized intensities)      NOV embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGGTTT
    NOV Expression
    About this image


    NOV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Superior Cervical Ganglion   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             Adrenal Cortex   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Late Floor Plate Cells Mesencephalic Floor Plate

    See NOV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOV

    SOURCE GeneReport for Unigene cluster: Hs.235935

    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor
    of the stromal type

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOV: 
              Estrogen Receptor Signaling in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NOV gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nov1 , 5 nephroblastoma overexpressed gene1, 5 82.57(n)1
    81.71(a)1
      15 (21.49 cM)5
    181331  NM_010930.41  NP_035060.11 
     547457025 
    chicken
    (Gallus gallus)
    Aves NOV1 nephroblastoma overexpressed gene 70.66(n)
    69.59(a)
      396204  NM_205268.1  NP_990599.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOV6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343269.1(903327-926561)
    African clawed frog
    (Xenopus laevis)
    Amphibia nov-A2 nephroblastoma overexpressed gene 72.2(n)    U37063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ccn6
    Ccn
    17(a)
    1 → many
    3L(17683115-17741939)


    ENSEMBL Gene Tree for NOV (if available)
    TreeFam Gene Tree for NOV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOV gene
    WISP22  CTGF2  WISP32  WISP12  CYR612  
    6 SIMAP similar genes for NOV using alignment to 2 protein entries:     NOV_HUMAN (see all proteins):
    CTGF    WISP2    WISP1    CYR61    LIBC    WISP3

    NOV for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/267 SNPs in NOV are shown (see all 267)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10577321,2
    C,F,Huntested1120707373(+) TCTGGT/CTTGTC 1 -- ut3190Minor allele frequency- C:0.06NS MN EA NA PA EU CA WA 4792
    rs20715261,2
    C,F,H--120697552(+) TCCCTG/ATCACC 1 -- us2k113Minor allele frequency- A:0.26EA NS NA WA CSA 2243
    rs585768061,2
    C,F--120697571(+) CCCACT/ACTTTC 1 -- us2k14Minor allele frequency- A:0.26WA NA 242
    rs105053551,2
    C,F,H--120697628(+) TATCTG/CAGTCT 1 -- us2k1106Minor allele frequency- C:0.11NS NA EA PA EU CA WA 6688
    rs761506321,2
    C,F--120697776(+) GGGCTC/GAGGAA 1 -- us2k11Minor allele frequency- G:0.05EA 120
    rs168925111,2
    C,F--120697857(+) TGGCTT/CACAAA 1 -- us2k17Minor allele frequency- C:0.22NA WA 376
    rs785020191,2
    C--120697920(+) AAGTTC/GAGGGG 1 -- us2k10--------
    rs1398913801,2
    --120698022(+) CATTAG/TTTATT 1 -- us2k10--------
    rs1848427851,2
    --120698143(+) AGTTTA/GAGTAC 1 -- us2k10--------
    rs168925121,2
    C,F,H--120698225(+) CTGCCG/AAGAGA 1 -- us2k121Minor allele frequency- A:0.06NA NS EA WA 2452

    HapMap Linkage Disequilibrium report for NOV (120428546 - 120436678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NOV:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527032CNV Loss19592680
    nsv521624CNV Loss19592680


    Human Gene Mutation Database (HGMD): NOV
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for NOV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164958    OMIM disorders: --

    20/29 diseases for NOV (see all 29):    About MalaCards
    autism spectrum disorder    nephroblastoma    alveolar rhabdomyosarcoma    marfan syndrome
    gastroenteritis    wilms tumor    hepatitis a    rhabdomyosarcoma
    eclampsia    pre-eclampsia    neurofibromatosis    diarrhea
    chondrosarcoma    glioblastoma    vitiligo    choriocarcinoma
    hypoxia    renal cell carcinoma    osteosarcoma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for NOV:
    Nephroblastoma

    NOV for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for NOV gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 83.8 60 9626060 (8), 7520150 (4), 9207876 (2), 15345329 (2) (see all 23)
    glioblastoma 29.4 9 14519668 (3), 12147716 (1), 9536281 (1)
    rhabdomyosarcoma 26.3 2 14996733 (1), 11891184 (1)
    glioma 25.2 27 11577170 (6), 18004727 (2), 15041728 (2), 15213231 (1)
    tumors 24.5 20 11891184 (3), 7520150 (2), 11751417 (2), 18418052 (2) (see all 10)
    breast cancer 0 4 19706598 (2)
    metastasis 0 4 11891184 (2), 15526358 (1)
    cancer 0 6 10474687 (2), 11477145 (1)

    Genetic Association Database (GAD): NOV
    Human Genome Epidemiology (HuGE) Navigator: NOV (8 documents)

    Export disorders for NOV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOV gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with NOV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of nov by WT1: a potential role for nov in nephrogenesis. (PubMed id 8622864)1, 2, 7, 9 Martinerie C.... Perbal B. (1996)
    2. Structural analysis of the human nov proto-oncogene and expression in Wilms tumor. (PubMed id 7520150)1, 2, 9 Martinerie C.... Perbal B. (1994)
    3. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PubMed id 9927660)1, 2, 9 Perbal B.... Roizman B. (1999)
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (2011)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily. (PubMed id 10084601)1, 7 Burren C.P....Rosenfeld R.G. (1999)
    10. Physical mapping of human loci homologous to the chicken nov proto-oncogene. (PubMed id 1334251)1, 3 Martinerie C....Perbal B. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4856 HGNC: 7885 AceView: NOV Ensembl:ENSG00000136999 euGenes: HUgn4856
    ECgene: NOV H-InvDB: NOV

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOV Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOV Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOV gene:
    Search GeneIP for patents involving NOV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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