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Aliases for NOV Gene

Aliases for NOV Gene

  • Nephroblastoma Overexpressed 2 3
  • Nephroblastoma-Overexpressed Gene Protein Homolog 3 4
  • Insulin-Like Growth Factor-Binding Protein 9 3 4
  • IGF-Binding Protein 9 3 4
  • CCN Family Member 3 3 4
  • IGFBP-9 3 4
  • IGFBP9 3 4
  • IBP-9 3 4
  • NOVh 3 4
  • CCN3 3 4
  • Nephroblastoma Overexpressed Gene 2
  • Protein NOV Homolog 3

External Ids for NOV Gene

Previous GeneCards Identifiers for NOV Gene

  • GC08P120434
  • GC08P120097
  • GC08P120385
  • GC08P120497
  • GC08P115749
  • GC08P120428

Summaries for NOV Gene

Entrez Gene Summary for NOV Gene

  • The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]

GeneCards Summary for NOV Gene

NOV (Nephroblastoma Overexpressed) is a Protein Coding gene. Diseases associated with NOV include wilms tumor. Among its related pathways are Adhesion and Signaling in Gap Junctions. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is WISP3.

UniProtKB/Swiss-Prot for NOV Gene

  • Immediate-early protein likely to play a role in cell growth regulation.

Gene Wiki entry for NOV Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOV Gene

Genomics for NOV Gene

Regulatory Elements for NOV Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOV Gene

119,416,306 bp from pter
119,424,438 bp from pter
8,133 bases
Plus strand

Genomic View for NOV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOV Gene

Proteins for NOV Gene

  • Protein details for NOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NOV homolog
    Protein Accession:
    Secondary Accessions:
    • B2R5X7
    • Q6I9S3
    • Q96BY5
    • Q9UDE4

    Protein attributes for NOV Gene

    357 amino acids
    Molecular mass:
    39162 Da
    Quaternary structure:
    • Interacts with FBLN1.

neXtProt entry for NOV Gene

Proteomics data for NOV Gene at MOPED

Post-translational modifications for NOV Gene

  • Glycosylation at Thr46, Thr49, Asn97, Asn280, Thr352, and Thr353
  • Modification sites at PhosphoSitePlus

Other Protein References for NOV Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NOV (NOV)

No data available for DME Specific Peptides for NOV Gene

Domains for NOV Gene

Gene Families for NOV Gene

Suggested Antigen Peptide Sequences for NOV Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the CCN family.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
  • Belongs to the CCN family.
genes like me logo Genes that share domains with NOV: view

Function for NOV Gene

Molecular function for NOV Gene

GENATLAS Biochemistry:
nephroblastoma overexpressed gene homolog (immediate early response gene),
UniProtKB/Swiss-Prot Function:
Immediate-early protein likely to play a role in cell growth regulation.
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by WT1.

Gene Ontology (GO) - Molecular Function for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IBA --
genes like me logo Genes that share ontologies with NOV: view
genes like me logo Genes that share phenotypes with NOV: view

Animal Models for NOV Gene

MGI Knock Outs for NOV:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NOV Gene

Localization for NOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOV Gene


Subcellular locations from

Jensen Localization Image for NOV Gene COMPARTMENTS Subcellular localization image for NOV gene
Compartment Confidence
extracellular 5
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with NOV: view

Pathways for NOV Gene

genes like me logo Genes that share pathways with NOV: view

Pathways by source for NOV Gene

1 Qiagen pathway for NOV Gene
1 Cell Signaling Technology pathway for NOV Gene
1 BioSystems pathway for NOV Gene
1 R&D Systems pathway for NOV Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007155 cell adhesion IBA --
GO:0007165 signal transduction IBA --
GO:0007267 cell-cell signaling IBA --
GO:0010468 regulation of gene expression IEA --
genes like me logo Genes that share ontologies with NOV: view

Drugs for NOV Gene

(2) Drugbank Compounds for NOV Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Insulin Regular
  • Insulin human
11061-68-0 Target approved, experimental, investigational
Insulin, porcine
9004-14-2 Target approved

(2) Novoseek inferred chemical compound relationships for NOV Gene

Compound -log(P) Hits PubMed IDs
cysteine 32.7 1
heparin 6.61 1
genes like me logo Genes that share compounds with NOV: view

Transcripts for NOV Gene

mRNA/cDNA for NOV Gene

(121) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOV Gene

Nephroblastoma overexpressed:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOV

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOV Gene

No ASD Table

Relevant External Links for NOV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOV Gene

mRNA expression in normal human tissues for NOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOV Gene

This gene is overexpressed in Adrenal Gland (14.4), Artery - Aorta (12.4), Artery - Tibial (8.5), and Artery - Coronary (8.0).

Protein differential expression in normal tissues for NOV Gene

This gene is overexpressed in Urine (23.2), Cerebral cortex (15.2), Amniocyte (11.9), Adrenal (10.9), and Cerebrospinal fluid (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOV Gene

SOURCE GeneReport for Unigene cluster for NOV Gene Hs.235935

mRNA Expression by UniProt/SwissProt for NOV Gene

Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
genes like me logo Genes that share expressions with NOV: view

Expression partners for NOV Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for NOV Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOV Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOV 35
  • 84.44 (n)
  • 80.87 (a)
NOV 36
  • 80 (a)
(Canis familiaris)
Mammalia NOV 35
  • 84.23 (n)
  • 81.3 (a)
NOV 36
  • 81 (a)
(Mus musculus)
Mammalia Nov 35
  • 82.57 (n)
  • 81.71 (a)
Nov 16
Nov 36
  • 81 (a)
(Pan troglodytes)
Mammalia NOV 35
  • 99.72 (n)
  • 99.16 (a)
NOV 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nov 35
  • 83.62 (n)
  • 81.71 (a)
(Monodelphis domestica)
Mammalia NOV 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NOV 36
  • 59 (a)
(Gallus gallus)
Aves NOV 35
  • 71.86 (n)
  • 71.65 (a)
NOV 36
  • 68 (a)
(Anolis carolinensis)
Reptilia NOV 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nov 35
  • 68.92 (n)
  • 63.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia nov-A 35
(Danio rerio)
Actinopterygii ctgfb 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 36 (a)
Species with no ortholog for NOV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOV Gene

Gene Tree for NOV (if available)
Gene Tree for NOV (if available)

Paralogs for NOV Gene

Paralogs for NOV Gene

(6) SIMAP similar genes for NOV Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOV: view

Variants for NOV Gene

Sequence variations from dbSNP and Humsavar for NOV Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs191846263 -- 119,423,973(+) AAGCA(C/G)TTGCT utr-variant-3-prime
rs191228164 -- 119,419,506(+) CCTAT(C/T)TTCTT intron-variant
rs190942008 -- 119,421,593(+) AGAAA(A/T)ATAAG intron-variant
rs190432361 -- 119,422,491(+) CTCCT(C/T)AATGT intron-variant
rs190013233 -- 119,424,653(+) GTATA(C/T)TGAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NOV Gene

Variant ID Type Subtype PubMed ID
nsv521624 CNV Loss 19592680
nsv527032 CNV Loss 19592680

Relevant External Links for NOV Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOV Gene

Disorders for NOV Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NOV Gene in MalaCards »

(1) Disease for NOV Gene

(1) University of Copenhagen DISEASES for NOV Gene

(8) Novoseek inferred disease relationships for NOV Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 83.8 37
glioblastoma 29.4 5
rhabdomyosarcoma 26.3 2
glioma 25.2 11
tumors 24.5 15

Relevant External Links for NOV

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NOV: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for NOV Gene

Publications for NOV Gene

  1. Regulation of nov by WT1: a potential role for nov in nephrogenesis. (PMID: 8622864) Martinerie C. … Perbal B. (Oncogene 1996) 3 4 23 25
  2. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PMID: 9927660) Perbal B. … Roizman B. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. Structural analysis of the human nov proto-oncogene and expression in Wilms tumor. (PMID: 7520150) Martinerie C. … Perbal B. (Oncogene 1994) 3 4 23
  4. Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression. (PMID: 10474687) Perbal B. (MP, Mol. Pathol. 1999) 3 23
  5. Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. (PMID: 16675545) Gellhaus A. … Winterhager E. (Mol. Hum. Reprod. 2006) 3 23

Products for NOV Gene

Sources for NOV Gene

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