Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NOV Gene

protein-coding   GIFtS: 61
GCID: GC08P120428

Nephroblastoma Overexpressed

(Previous name: nephroblastoma overexpressed gene)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nephroblastoma Overexpressed1 2     CCN Family Member 32 3
Insulin-Like Growth Factor-Binding Protein 92 3     IGF-Binding Protein 92 3
Nephroblastoma-Overexpressed Gene Protein Homolog2 3     Nephroblastoma Overexpressed Gene1
CCN32 3     NOVh2
IBP-92 3     Protein NOV Homolog2
IGFBP-92 3     NOVH3
IGFBP92 3     NovH3

External Ids:    HGNC: 78851   Entrez Gene: 48562   Ensembl: ENSG000001369997   OMIM: 1649585   UniProtKB: P487453   

Export aliases for NOV gene to outside databases

Previous GC identifers: GC08P119415 GC08P120434 GC08P120097 GC08P120385 GC08P120497 GC08P115749


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOV Gene:
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of
regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in
cardiovascular and skeletal development, fibrosis and cancer development. (provided by RefSeq, Feb 2009)

GeneCards Summary for NOV Gene:
NOV (nephroblastoma overexpressed) is a protein-coding gene. Diseases associated with NOV include nephroblastoma, and alveolar rhabdomyosarcoma. GO annotations related to this gene include growth factor activity and insulin-like growth factor binding. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)

Gene Wiki entry for NOV Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOV gene promoter:
         c-Fos   AP-1   ATF-2   MyoD   IRF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOV promoter sequence
   Search Chromatin IP Primers for NOV

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.1   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.12

NOV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOV gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120428:  view genomic region     (about GC identifiers)

Start:
120,428,546 bp from pter      End:
120,436,678 bp from pter
Size:
8,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOV_HUMAN, P48745 (See protein sequence)
Recommended Name: Protein NOV homolog precursor  
Size: 357 amino acids; 39162 Da
Subunit: Interacts with FBLN1
Secondary accessions: B2R5X7 Q6I9S3 Q96BY5 Q9UDE4

Explore the universe of human proteins at neXtProt for NOV: NX_P48745

Explore proteomics data for NOV at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr46, Thr49, Asn97, Asn280, Thr352, Thr353
  • Modification sites at PhosphoSitePlus

  • See NOV Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002505.1  
    ENSEMBL proteins: 
     ENSP00000259526  

    NOV Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NOV (NOV/CCN3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NOV
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NOV
    GenScript Custom Purified and Recombinant Proteins Services for NOV
    Novus Biologicals NOV Proteins
    Novus Biologicals NOV Lysates
    Sino Biological Recombinant Protein for NOV
    Sino Biological Cell Lysate for NOV
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOV

    NOV Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NOV (NOV/CCN3)
    Cell Signaling Technology (CST) Antibodies for NOV 
    OriGene Antibodies for NOV
    OriGene Custom Antibody Services for NOV
    Novus Biologicals NOV Antibodies
    Search for Antibodies for NOV at Abcam
    Cloud-Clone Corp. Antibodies for NOV
    ThermoFisher Antibody for NOV
    LSBio Antibodies in human, mouse, rat for NOV

    NOV Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOV
    R&D Systems ELISAs for NOV (NOV/CCN3)
    GenScript Custom Assay Services for NOV
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOV
    Cloud-Clone Corp. CLIAs for NOV


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR017891 Insulin_GF-bd_Cys-rich_CS
     IPR009030 Growth_fac_rcpt_N_dom
     IPR006207 Cys_knot_C
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry P48745

    ProtoNet protein and cluster: P48745

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    NOV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOV_HUMAN, P48745
    Function: Immediate-early protein likely to play a role in cell growth regulation (By similarity)
    Induction: Expression is down-regulated by WT1

         Genatlas biochemistry entry for NOV:
    nephroblastoma overexpressed gene homolog (immediate early response gene),

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    NOV for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nov) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  renal/urinary system  skeleton 

    NOV for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOV: Novtm1Cabo Novtm1Hko

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOV
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOV
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOV

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NOV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidNOV 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOV
    Predesigned siRNA for gene silencing in human, mouse, rat NOV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOV

    Clone
    Products:
         
    OriGene clones in human, mouse for NOV (see all 7)
    OriGene ORF clones in mouse, rat for NOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOV (NM_002514)
    Sino Biological Human cDNA Clone for NOV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOV

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOV
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOV 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOV_HUMAN, P48745: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--
    GO:0031012extracellular matrix IEA--
    GO:0043025neuronal cell body IEA--

    NOV for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NOV About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    2Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    3Notch Signaling Pathways
    Notch Signaling Pathways
    4Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOV
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NOV
        Signaling in Gap Junctions

    1 Cell Signaling Technology (CST) Pathway for NOV
        Adhesion

    1 BioSystems Pathway for NOV
        Delta-Notch Signaling Pathway




    NOV for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOV: 
              Estrogen Receptor Signaling in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for NOV (P487453 ENSP000002595264) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    IGF1P050193, ENSP000003026654I2D: score=2 STRING: ENSP00000302665
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    GJA1P173023, ENSP000002825614I2D: score=1 STRING: ENSP00000282561
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0010468regulation of gene expression IEA--

    NOV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOV

    2 DrugBank Compounds for NOV    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--8622864 12149257 17016423 17139284 10084601
    Insulin Regular -- 11061-68-0target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for NOV gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 32.7 1 12050162 (1)
    heparin 6.61 1 11584015 (1)



    NOV for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NOV gene: 
    NM_002514.3  

    Unigene Cluster for NOV:

    Nephroblastoma overexpressed
    Hs.235935  [show with all ESTs]
    Unigene Representative Sequence: NM_002514
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259526(uc003yoq.2) ENST00000520082
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOV (see all 10):
    hsa-miR-3163 hsa-miR-4324 hsa-miR-520d-5p hsa-miR-3935 hsa-miR-27b* hsa-miR-582-5p hsa-miR-544b hsa-miR-4253
    SwitchGear 3'UTR luciferase reporter plasmidNOV 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOV
    Predesigned siRNA for gene silencing in human, mouse, rat NOV
    Clone
    Products:
         
    OriGene clones in human, mouse for NOV (see all 7)
    OriGene ORF clones in mouse, rat for NOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOV (NM_002514)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOV
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOV
    OriGene qSTAR qPCR primer pairs in human, mouse for NOV
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOV
      QuantiTect SYBR Green Assays in human, mouse, rat NOV
      QuantiFast Probe-based Assays in human, mouse, rat NOV

    Additional mRNA sequence: 

    AK294289.1 AK312355.1 AY082381.1 BC015028.1 CR457432.1 X96584.1 

    4 DOTS entries:

    DT.114995  DT.100814969  DT.95267727  DT.100829939 

    Selected AceView cDNA sequences (see all 121):

    AI925049 BQ774547 AI920781 BI850600 AI783828 BF440025 AA687861 BI491099 
    CR591257 CA449356 BM984571 AV710966 CR623165 AI440024 CD107552 CA447986 
    AL556435 BX477828 BG105327 NM_002514 CA449602 BU188978 BC015028 BQ006363 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NOV expression in normal human tissues (normalized intensities)      NOV embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTGGTTT
    NOV Expression
    About this image


    NOV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Chorion (Extraembryonic Tissues)
             Villous Stromal Cells Chorionic Villus
    NOV Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOV Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.235935

    UniProtKB/Swiss-Prot: NOV_HUMAN, P48745
    Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor
    of the stromal type

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOV: 
              Estrogen Receptor Signaling in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOV
    OriGene qSTAR qPCR primer pairs in human, mouse for NOV
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOV
    QuantiTect SYBR Green Assays in human, mouse, rat NOV
    QuantiFast Probe-based Assays in human, mouse, rat NOV
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NOV gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nov1 , 5 nephroblastoma overexpressed gene1, 5 82.57(n)1
    81.71(a)1
      15 (21.49 cM)5
    181331  NM_010930.41  NP_035060.11 
     547457025 
    chicken
    (Gallus gallus)
    Aves NOV1 nephroblastoma overexpressed gene 71.86(n)
    71.65(a)
      396204  NM_205268.1  NP_990599.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOV6
    nephroblastoma overexpressed
    62(a)
    1 ↔ 1
    GL343269.1(903327-926561)
    African clawed frog
    (Xenopus laevis)
    Amphibia nov-A2 nephroblastoma overexpressed gene 72.2(n)    U37063.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctgfb6
    connective tissue growth factor b
    47(a)
    many ↔ many
    19(30254599-30259809) ENSDARG00000070586


    ENSEMBL Gene Tree for NOV (if available)
    TreeFam Gene Tree for NOV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NOV gene
    WISP22  CTGF2  WISP32  WISP12  CYR612  
    6 SIMAP similar genes for NOV using alignment to 2 protein entries:     NOV_HUMAN (see all proteins):
    CTGF    WISP2    WISP1    CYR61    LIBC    WISP3

    NOV for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NOV (see all 267)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10577321,2
    C,F,Huntested1120707373(+) TCTGGT/CTTGTC 1 -- ut3190Minor allele frequency- C:0.06NS MN EA NA PA EU CA WA 4792
    rs20715261,2
    C,F,H--120697552(+) TCCCTG/ATCACC 1 -- us2k113Minor allele frequency- A:0.26EA NS NA WA CSA 2243
    rs585768061,2
    C,F--120697571(+) CCCACT/ACTTTC 1 -- us2k14Minor allele frequency- A:0.26WA NA 242
    rs105053551,2
    C,F,H--120697628(+) TATCTG/CAGTCT 1 -- us2k1106Minor allele frequency- C:0.11NS NA EA PA EU CA WA 6688
    rs761506321,2
    C,F--120697776(+) GGGCTC/GAGGAA 1 -- us2k11Minor allele frequency- G:0.05EA 120
    rs168925111,2
    C,F--120697857(+) TGGCTT/CACAAA 1 -- us2k17Minor allele frequency- C:0.22NA WA 376
    rs785020191,2
    C--120697920(+) AAGTTC/GAGGGG 1 -- us2k10--------
    rs1398913801,2
    --120698022(+) CATTAG/TTTATT 1 -- us2k10--------
    rs1848427851,2
    --120698143(+) AGTTTA/GAGTAC 1 -- us2k10--------
    rs168925121,2
    C,F,H--120698225(+) CTGCCG/AAGAGA 1 -- us2k121Minor allele frequency- A:0.06NA NS EA WA 2452

    HapMap Linkage Disequilibrium report for NOV (120428546 - 120436678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NOV:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527032CNV Loss19592680
    nsv521624CNV Loss19592680

    Human Gene Mutation Database (HGMD): NOV
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOV
    DNA2.0 Custom Variant and Variant Library Synthesis for NOV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 164958    OMIM disorders: --

    Selected diseases for NOV (see all 30):    About MalaCards
    nephroblastoma    alveolar rhabdomyosarcoma    marfan syndrome    hepatitis a
    wilms tumor    gastroenteritis    rhabdomyosarcoma    vitiligo
    neurofibromatosis    eclampsia    diarrhea    pre-eclampsia
    autism spectrum disorder    chondrosarcoma    choriocarcinoma    osteosarcoma
    hypoxia    renal cell carcinoma    endotheliitis    kidney disease

    1 disease from the University of Copenhagen DISEASES database for NOV:
    Nephroblastoma

    NOV for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for NOV gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 83.8 60 9626060 (8), 7520150 (4), 9207876 (2), 15345329 (2) (see all 23)
    glioblastoma 29.4 9 14519668 (3), 12147716 (1), 9536281 (1)
    rhabdomyosarcoma 26.3 2 14996733 (1), 11891184 (1)
    glioma 25.2 27 11577170 (6), 18004727 (2), 15041728 (2), 15213231 (1)
    tumors 24.5 20 11891184 (3), 7520150 (2), 11751417 (2), 18418052 (2) (see all 10)
    breast cancer 0 4 19706598 (2)
    metastasis 0 4 11891184 (2), 15526358 (1)
    cancer 0 6 10474687 (2), 11477145 (1)

    Genetic Association Database (GAD): NOV
    Human Genome Epidemiology (HuGE) Navigator: NOV (8 documents)

    Export disorders for NOV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NOV gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with NOV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of nov by WT1: a potential role for nov in nephrogenesis. (PubMed id 8622864)1, 2, 7, 9 Martinerie C.... Perbal B. (Oncogene 1996)
    2. Structural analysis of the human nov proto-oncogene and expression in Wilms tumor. (PubMed id 7520150)1, 2, 9 Martinerie C.... Perbal B. (Oncogene 1994)
    3. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (PubMed id 9927660)1, 2, 9 Perbal B.... Roizman B. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily. (PubMed id 10084601)1, 7 Burren C.P....Rosenfeld R.G. (J. Clin. Endocrinol. Metab. 1999)
    10. Physical mapping of human loci homologous to the chicken nov proto-oncogene. (PubMed id 1334251)1, 3 Martinerie C....Perbal B. (Oncogene 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4856 HGNC: 7885 AceView: NOV Ensembl:ENSG00000136999 euGenes: HUgn4856
    ECgene: NOV H-InvDB: NOV

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NOV Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOV Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NOV gene:
    Search GeneIP for patents involving NOV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NOV (NOV/CCN3)   Browse Cell Culture Products  
     ELISAs for NOV (NOV/CCN3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NOV (NOV/CCN3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NOV   OriGene RNAi products in human, mouse, rat for NOV  
     OriGene qPCR primer pairs and template standards for NOV   OriGene Protein Over-expression Lysate for NOV  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NOV  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOV   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NOV   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOV   OriGene Custom Protein Services for NOV  

     
     
     Block miRNA regulation of human, mouse, rat NOV using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NOV
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOV Predesigned siRNA for gene silencing in human, mouse, rat NOV
     QuantiFast Probe-based Assays in human, mouse, rat NOV QuantiTect SYBR Green Assays in human, mouse, rat NOV
     PCR Arrays including human, mouse, rat NOV Search Chromatin IP Primers for NOV
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOV  GeneGlobe Interaction Network for NOV
     Regulatory tfbs in NOV promoter
     GenScript Custom Purified and Recombinant Proteins Services for NOV GenScript cDNA clones with any tag delivered in your preferred vector for NOV
     GenScript Custom Assay Services for NOV GenScript Custom overexpressing Cell Line Services for NOV
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NOV 

     Search Tocris compounds for NOV
     Proteins for NOV
     Cell Lysates for NOV
     cDNA Clones for NOV
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NOV antibodies
     NOV proteins
     NOV lysates
     Search for Antibodies for NOV at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NOV
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NOV
     Antibodies for NOV
     ELISAs for NOV
     CLIAs for NOV



     Browse ESI BIO Cell Lines and PureStem Progenitors for NOV
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOV
     SwitchGear 3'UTR luciferase reporter plasmids for NOV
     SwitchGear Promoter luciferase reporter plasmids for NOV
     ThermoFisher Antibody for NOV
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOV
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOV
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOV
     LSBio Antibodies in human, mouse, rat for NOV
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOV gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4