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Aliases for NOTUM Gene

Aliases for NOTUM Gene

  • Notum Pectinacetylesterase Homolog (Drosophila) 2 3
  • EC 3.1.1.- 4
  • HNOTUM 4

External Ids for NOTUM Gene

Previous GeneCards Identifiers for NOTUM Gene

  • GC17M077504
  • GC17M079910
  • GC17M075311

Summaries for NOTUM Gene

GeneCards Summary for NOTUM Gene

NOTUM (Notum Pectinacetylesterase Homolog (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for NOTUM Gene

  • Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOTUM Gene

Genomics for NOTUM Gene

Regulatory Elements for NOTUM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOTUM Gene

Start:
81,952,507 bp from pter
End:
81,961,840 bp from pter
Size:
9,334 bases
Orientation:
Minus strand

Genomic View for NOTUM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOTUM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTUM Gene

Proteins for NOTUM Gene

  • Protein details for NOTUM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P988-NOTUM_HUMAN
    Recommended name:
    Palmitoleoyl-protein carboxylesterase NOTUM
    Protein Accession:
    Q6P988
    Secondary Accessions:
    • Q8N410
    • Q8NI82

    Protein attributes for NOTUM Gene

    Size:
    496 amino acids
    Molecular mass:
    55699 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36872.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH60882.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB93501.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOTUM Gene

neXtProt entry for NOTUM Gene

Proteomics data for NOTUM Gene at MOPED

Post-translational modifications for NOTUM Gene

  • Glycosylation at Asn96
  • Modification sites at PhosphoSitePlus

Other Protein References for NOTUM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NOTUM

No data available for DME Specific Peptides for NOTUM Gene

Domains for NOTUM Gene

Protein Domains for NOTUM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOTUM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P988

UniProtKB/Swiss-Prot:

NOTUM_HUMAN :
  • Q6P988
Family:
  • Belongs to the pectinacetylesterase family. Notum subfamily.
genes like me logo Genes that share domains with NOTUM: view

No data available for Gene Families for NOTUM Gene

Function for NOTUM Gene

Molecular function for NOTUM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[Wnt]-O-(9Z)-hexadecenoyl-L-serine + H(2)O = [Wnt]-L-serine + (9Z)-hexadecenoate.
UniProtKB/Swiss-Prot Function:
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
UniProtKB/Swiss-Prot Induction:
Up-regulated in hepatocellular carcinoma (HCC) with high intracellular beta-catenin.

Enzyme Numbers (IUBMB) for NOTUM Gene

Gene Ontology (GO) - Molecular Function for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:1990699 palmitoleyl hydrolase activity IDA 25731175
genes like me logo Genes that share ontologies with NOTUM: view

Phenotypes for NOTUM Gene

GenomeRNAi human phenotypes for NOTUM:
genes like me logo Genes that share phenotypes with NOTUM: view

miRNA for NOTUM Gene

miRTarBase miRNAs that target NOTUM

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOTUM

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NOTUM Gene

Localization for NOTUM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTUM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOTUM Gene COMPARTMENTS Subcellular localization image for NOTUM gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NOTUM: view

Pathways for NOTUM Gene

SuperPathways for NOTUM Gene

No Data Available

Interacting Proteins for NOTUM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000387310%0d%0a9606.ENSP00000358554%0d%0a
Selected Interacting proteins: ENSP00000387310 for NOTUM Gene via STRING

Symbol External ID(s) Details
BCAS2

Gene Ontology (GO) - Biological Process for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0030178 negative regulation of Wnt signaling pathway IDA 25731175
GO:1990697 protein depalmitoleylation IDA 25731175
genes like me logo Genes that share ontologies with NOTUM: view

No data available for Pathways by source for NOTUM Gene

Transcripts for NOTUM Gene

mRNA/cDNA for NOTUM Gene

Unigene Clusters for NOTUM Gene

Notum pectinacetylesterase homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOTUM

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOTUM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -

Relevant External Links for NOTUM Gene

GeneLoc Exon Structure for
NOTUM
ECgene alternative splicing isoforms for
NOTUM

Expression for NOTUM Gene

mRNA expression in normal human tissues for NOTUM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOTUM Gene

This gene is overexpressed in Liver (10.6), Muscle - Skeletal (5.8), and Testis (4.4).

Protein differential expression in normal tissues for NOTUM Gene

This gene is overexpressed in Placenta (68.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOTUM Gene

SOURCE GeneReport for Unigene cluster for NOTUM Gene Hs.106137

mRNA Expression by UniProt/SwissProt for NOTUM Gene

Q6P988-NOTUM_HUMAN
Tissue specificity: Rarely expressed in adult normal tissues.
genes like me logo Genes that share expressions with NOTUM: view

Expression partners for NOTUM Gene

In Situ Assay Products

Orthologs for NOTUM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOTUM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOTUM 35
  • 91.29 (n)
  • 94.03 (a)
dog
(Canis familiaris)
Mammalia NOTUM 35
  • 90.34 (n)
  • 93.49 (a)
NOTUM 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Notum 35
  • 86.9 (n)
  • 90.73 (a)
Notum 16
Notum 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOTUM 35
  • 97.32 (n)
  • 96.88 (a)
NOTUM 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Notum 35
  • 87.16 (n)
  • 90.52 (a)
oppossum
(Monodelphis domestica)
Mammalia NOTUM 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOTUM 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOTUM 35
  • 79.19 (n)
  • 87.8 (a)
NOTUM 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOTUM 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia notum 35
  • 72.73 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii notum1a 35
  • 74.15 (n)
  • 78.44 (a)
NOTUM (3 of 3) 36
  • 67 (a)
OneToMany
notum1a 36
  • 72 (a)
OneToMany
notum2 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Notum 35
  • 55.47 (n)
  • 48.23 (a)
Notum 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45280 35
  • 39.86 (n)
  • 28.7 (a)
rice
(Oryza sativa)
Liliopsida Os04g0602500 35
  • 41.26 (n)
  • 31.71 (a)
Species with no ortholog for NOTUM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOTUM Gene

ENSEMBL:
Gene Tree for NOTUM (if available)
TreeFam:
Gene Tree for NOTUM (if available)

Paralogs for NOTUM Gene

No data available for Paralogs for NOTUM Gene

Variants for NOTUM Gene

Sequence variations from dbSNP and Humsavar for NOTUM Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs882810 -- 81,952,034(-) actcc(G/T)gggct downstream-variant-500B
rs1879567 -- 81,957,523(-) GGGAC(A/C)TAAGT intron-variant
rs2102988 -- 81,954,787(-) ATACA(A/G)AAATT intron-variant
rs4270220 -- 81,952,826(-) TATGC(C/T)CACTG utr-variant-3-prime
rs4456551 -- 81,952,909(-) GCTGC(A/C)CCAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOTUM Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897
nsv828137 CNV Loss 20364138
dgv3343n71 CNV Loss 21882294

Relevant External Links for NOTUM Gene

HapMap Linkage Disequilibrium report
NOTUM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTUM Gene

Disorders for NOTUM Gene

No disorders were found for NOTUM Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NOTUM Gene

Publications for NOTUM Gene

  1. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. (PMID: 18429952) Torisu Y. … Aburatani H. (Cancer Sci. 2008) 3 4
  2. Notum deacylates Wnt proteins to suppress signalling activity. (PMID: 25731175) Kakugawa S. … Vincent J.P. (Nature 2015) 3 4
  3. HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. (PMID: 12015973) Giraldez A.J. … Cohen S.M. (Dev. Cell 2002) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for NOTUM Gene

Sources for NOTUM Gene

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