Aliases for NOTUM Gene
External Ids for NOTUM Gene
Previous GeneCards Identifiers for NOTUM Gene
GeneCards Summary for NOTUM Gene
NOTUM (NOTUM, Palmitoleoyl-Protein Carboxylesterase) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and palmitoleyl hydrolase activity.
UniProtKB/Swiss-Prot for NOTUM Gene
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).