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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOTUM Gene

protein-coding   GIFtS: 45
GCID: GC17M079910

notum pectinacetylesterase homolog (Drosophila)
 Explore 3 diseases affiliated with
NOTUM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NOTUM    

Aliases
for NOTUM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Notum Pectinacetylesterase Homolog (Drosophila)1 2
Protein Notum Homolog2
EC 3.-.-.-3

External Ids:    HGNC: 271061   Entrez Gene: 1471112   Ensembl: ENSG000001852697   OMIM: 6098475   UniProtKB: Q6P9883   

Export aliases for NOTUM gene to outside databases

Previous GC identifers: GC17M077504 GC17M075311


Summaries
for NOTUM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NOTUM_HUMAN, Q6P988
Function: May deacetylate GlcNAc residues on cell surface glycans (Potential)




Genomic Views
for NOTUM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOTUM gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   E2F-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOTUM promoter sequence
   Search SABiosciences Chromatin IP Primers for NOTUM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOTUM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NOTUM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOTUM gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079910:  view genomic region     (about GC identifiers)

Start:
 79,910,383 bp from pter      End:
 79,919,716 bp from pter
Size:
 9,334 bases      Orientation:
 minus strand

Proteins
for NOTUM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NOTUM_HUMAN, Q6P988 (See protein sequence)
Recommended Name: Protein notum homolog precursor  
Size: 496 amino acids; 55699 Da
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=AAH36872.2; Type=Erroneous initiation; Sequence=AAH60882.1; Type=Erroneous initiation;
Sequence=BAB93501.1; Type=Erroneous initiation;
Secondary accessions: Q8N410 Q8NI82

Explore the universe of human proteins at neXtProt for NOTUM: NX_Q6P988

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P988

    • NOTUM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848588.3  
    ENSEMBL proteins: 
     ENSP00000387310   ENSP00000464734   ENSP00000407905  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NOTUM
    OriGene Protein Over-expression Lysate: NOTUM
    OriGene Custom Protein Services for NOTUM 
    GenScript Custom Purified and Recombinant Proteins Services for NOTUM
    Novus Biologicals NOTUM Proteins
    Novus Biologicals NOTUM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NOTUM

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    NOTUM for ontologies           About GeneDecksing



    NOTUM Antibody Products: 
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    Uscn Antibodies for NOTUM
    ThermoFisher Antibodies for NOTUM

    Assay Products for NOTUM: 
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for NOTUM
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NOTUM

    Protein Domains /
    Families
    for NOTUM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOTUM for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004963 Pec_acetylest

    Graphical View of Domain Structure for InterPro Entry Q6P988

    ProtoNet protein and cluster: Q6P988

    UniProtKB/Swiss-Prot: NOTUM_HUMAN, Q6P988
    Similarity: Belongs to the pectinacetylesterase family


    Function
    for NOTUM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NOTUM_HUMAN, Q6P988
    Function: May deacetylate GlcNAc residues on cell surface glycans (Potential)

    Enzyme Number (IUBMB): EC 3.-.-.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NOTUM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOTUM
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NOTUM (see all 22):
    hsa-miR-548j hsa-miR-520f hsa-miR-520d-5p hsa-miR-548i hsa-miR-548k hsa-miR-340 hsa-miR-548l hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NOTUM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTUM (see all 4)
    OriGene shRNA RFP: NOTUM
    OriGene siRNA: NOTUM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTUM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NOTUM

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NOTUM (NM_178493)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTUM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTUM 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NOTUM
    Search LifeMap BioReagents cell lines for NOTUM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTUM

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--


    NOTUM for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NOTUM:
     Increased S DNA content  Increased number of mitotic ce 


    Pathways & Interactions
    for NOTUM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOTUM

    Drugs & Compounds
    for NOTUM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOTUM
    Search CenterWatch for drugs/clinical trials and news about NOTUM 

    Transcripts
    for NOTUM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOTUM gene: 
    NM_178493.5  

    Unigene Cluster for NOTUM:

    Notum pectinacetylesterase homolog (Drosophila)
    Hs.106137  [show with all ESTs]
    Unigene Representative Sequence: NM_178493
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409678(uc010wvg.2) ENST00000477214 ENST00000425009 ENST00000489218


    miRNA
    Products:             		 OriGene 3'-UTR Clone: NOTUM
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOTUM
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NOTUM (see all 22):
    hsa-miR-548j hsa-miR-520f hsa-miR-520d-5p hsa-miR-548i hsa-miR-548k hsa-miR-340 hsa-miR-548l hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NOTUM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTUM (see all 4)
    OriGene shRNA RFP: NOTUM
    OriGene siRNA: NOTUM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTUM
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NOTUM (NM_178493)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTUM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTUM 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTUM
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOTUM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTUM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTUM

    Additional cDNA sequence: 

    AB062438.1 BC036872.1 BC060882.1 

    10 DOTS entries:

    DT.207674  DT.100779099  DT.100697273  DT.100776173  DT.100836237  DT.102844163  DT.75178757  DT.100697272 
    DT.92032324  DT.95362858 

    24/77 AceView cDNA sequences (see all 77):

    BX403266 CR622664 AA954284 BX339827 BU681461 BF055223 AW340232 CR596332 
    BX417867 BX952672 BM996484 AA700861 AB062438 BX365997 CR596699 BX380856 
    CA414282 AA133536 AI220017 AW340565 BC060882 BC036872 AI129973 AI089180 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOTUM    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                     
    SP2:              -                                                                     
    SP3:                                -                                                   


    ECgene alternative splicing isoforms for NOTUM

    Expression
    for NOTUM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOTUM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGACGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NOTUM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    LiverLiver LobulePerivenous HepatocytesLiver
    LungTracheaLung
    Reproductive SystemVas DeferensReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NOTUM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOTUM

    SOURCE GeneReport for Unigene cluster: Hs.106137
        SABiosciences Custom PCR Arrays for NOTUM
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTUM
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOTUM
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTUM
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTUM
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTUM

    Orthologs
    for NOTUM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOTUM gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Notum1 , 5 notum pectinacetylesterase homolog (Drosophila)1, 5 86.96(n)1
    90.93(a)1    		   11 (84.38 cM)5
    775831  NM_175263.41  NP_780472.31 
     1206537885 
    chicken
    (Gallus gallus)    		 Aves NOTUM1 notum pectinacetylesterase homolog (Drosophila) 79.19(n)
    87.8(a)    		   417385  XM_415640.3  XP_415640.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NOTUM6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 2(118377762-118400345)
    zebrafish
    (Danio rerio)    		 Actinopterygii notum1a1 notum pectinacetylesterase 1a 72.7(n)
    76.3(a)    		   570510  NM_001161654.1  NP_001155126.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Notum1 CG13076-PA 55.64(n)
    48.23(a)    		   39751  NM_168643.2  NP_730096.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G194201 putative Pectinacetylesterase 40.07(n)
    34.2(a)    		   827683  NM_118062.6  NP_193677.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g07024001 hypothetical protein 43.03(n)
    33.64(a)    		   4330443  NM_001054385.1  NP_001047850.1 


    ENSEMBL Gene Tree for NOTUM (if available)
    TreeFam Gene Tree for NOTUM (if available) 

    Paralogs
    for NOTUM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NOTUM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/190 NCBI SNPs in NOTUM are shown (see all 190)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs8828101,2
    		C,F,A,H,--79909910(-) ACTCCT/GGGGCT 1 -- int115Minor allele frequency- G:0.46NS EA NA WA CSA 778
    rs1483224231,2
    		--79910072(+) GCAGGA/GCCCCT 1 -- int10--------
    rs97470741,2
    		C,F,H,--79910165(+) GCTGCC/TGTGGG 1 -- int17Minor allele frequency- T:0.01NS NA WA 812
    rs1851112381,2
    		--79910248(+) GAGGGC/GAGGGA 1 -- int10--------
    rs620786871,2
    		C,--79910313(+) GAGGAA/GGGGAG 1 -- int10--------
    rs1895757371,2
    		--79910346(+) AGGAGA/GAGGGG 1 -- int10--------
    rs1928514721,2
    		--79910375(+) CACGCA/GGGCAG 1 -- int10--------
    rs1836615661,2
    		--79910448(+) TCATAC/TATTCT 1 -- ut310--------
    rs1882853481,2
    		--79910468(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs1807624121,2
    		--79910763(+) TGCTGA/GTGGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NOTUM (79910383 - 79919716 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for NOTUM
         5 CNVs: 23319 30036 5042 73078 5041

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOTUM
    DNA2.0 Custom Variant and Variant Library Synthesis for NOTUM

    Disorders / Diseases
    for NOTUM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NOTUM for disorders           About GeneDecksing

    OMIM gene information: 609847    OMIM disorders: --

    3 diseases for NOTUM:    About MalaCards
    scabies    hepatocellular carcinoma    carcinoma


    Export disorders for NOTUM gene to outside databases

    Publications
    for NOTUM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOTUM gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NOTUM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. (PubMed id 18429952)1 Torisu Y....Aburatani H. (2008)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. (PubMed id 12015973)2 Giraldez A.J.... Cohen S.M. (2002)

    External Searches for NOTUM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOTUM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147111 HGNC: 27106 AceView: LOC147111 Ensembl:ENSG00000185269 euGenes: HUgn147111
    ECgene: NOTUM H-InvDB: NOTUM

    Other Databases showing NOTUM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOTUM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOTUM Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NOTUM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOTUM gene:
    Search GeneIP for patents involving NOTUM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NOTUM gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
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     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NOTUM   OriGene shRNA RFP for NOTUM  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTUM   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTUM  
     OriGene Protein Over-expression Lysate for NOTUM   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NOTUM   OriGene 3'-UTR Clone for NOTUM  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTUM  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NOTUM   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOTUM   OriGene Custom Protein Services for NOTUM  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOTUM
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOTUM
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOTUM
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTUM
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTUM
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTUM
     GenScript Custom Purified and Recombinant Proteins Services for NOTUM GenScript cDNA clones with any tag delivered in your preferred vector for NOTUM
     GenScript Custom Assay Services for NOTUM GenScript Custom Superior Antibodies Services for NOTUM
     GenScript Custom overexpressing Cell Line Services for NOTUM CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NOTUM promoter
     Search Chromatin IP Primers for NOTUM
     RT2 qPCR Primer Assay in human, mouse, rat NOTUM
     Search GNC Networks for NOTUM
     SABiosciences Custom PCR Arrays for NOTUM
     Search Tocris compounds for NOTUM
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NOTUM antibodies
     NOTUM proteins
     NOTUM lysates
     Search for Antibodies for NOTUM at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NOTUM
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NOTUM Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NOTUM
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTUM
     SwitchGear 3'UTR luciferase reporter plasmids for NOTUM
     SwitchGear Promoter luciferase reporter plasmids for NOTUM
     ThermoFisher Antibodies for NOTUM
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTUM
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

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