External Ids for NOTO Gene
Previous GeneCards Identifiers for NOTO Gene
GeneCards Summary for NOTO Gene
NOTO (Notochord Homeobox) is a Protein Coding gene. Diseases associated with NOTO include diphyllobothriasis and central sleep apnea. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EN2.
UniProtKB/Swiss-Prot for NOTO Gene
Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).