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Aliases for NOTO Gene

Aliases for NOTO Gene

  • Notochord Homeobox 2 3
  • Notochord Homolog (Xenopus Laevis) 2

External Ids for NOTO Gene

Previous GeneCards Identifiers for NOTO Gene

  • GC02P073341
  • GC02P073283
  • GC02P073429
  • GC02P073165

Summaries for NOTO Gene

GeneCards Summary for NOTO Gene

NOTO (Notochord Homeobox) is a Protein Coding gene. Diseases associated with NOTO include diphyllobothriasis and central sleep apnea. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EN2.

UniProtKB/Swiss-Prot for NOTO Gene

  • Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOTO Gene

Genomics for NOTO Gene

Regulatory Elements for NOTO Gene

Genomic Location for NOTO Gene

Start:
73,202,258 bp from pter
End:
73,212,513 bp from pter
Size:
10,256 bases
Orientation:
Plus strand

Genomic View for NOTO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOTO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTO Gene

Proteins for NOTO Gene

  • Protein details for NOTO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTQ0-NOTO_HUMAN
    Recommended name:
    Homeobox protein notochord
    Protein Accession:
    A8MTQ0
    Secondary Accessions:
    • B4DJ59
    • B7ZAU5

    Protein attributes for NOTO Gene

    Size:
    251 amino acids
    Molecular mass:
    27003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOTO Gene

Proteomics data for NOTO Gene at MOPED

Post-translational modifications for NOTO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOTO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOTO Gene

Domains for NOTO Gene

Gene Families for NOTO Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for NOTO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOTO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MTQ0

UniProtKB/Swiss-Prot:

NOTO_HUMAN :
  • A8MTQ0
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with NOTO: view

Function for NOTO Gene

Molecular function for NOTO Gene

UniProtKB/Swiss-Prot Function: Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).

Gene Ontology (GO) - Molecular Function for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NOTO: view
genes like me logo Genes that share phenotypes with NOTO: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NOTO Gene

Localization for NOTO Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTO Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOTO Gene COMPARTMENTS Subcellular localization image for NOTO gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NOTO: view

Pathways for NOTO Gene

SuperPathways for NOTO Gene

No Data Available

Interacting Proteins for NOTO Gene

Gene Ontology (GO) - Biological Process for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0009880 embryonic pattern specification IEA --
GO:0009953 dorsal/ventral pattern formation IEA --
genes like me logo Genes that share ontologies with NOTO: view

No data available for Pathways by source for NOTO Gene

Transcripts for NOTO Gene

mRNA/cDNA for NOTO Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOTO Gene

Notochord homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOTO Gene

No ASD Table

Relevant External Links for NOTO Gene

GeneLoc Exon Structure for
NOTO
ECgene alternative splicing isoforms for
NOTO

Expression for NOTO Gene

mRNA expression in normal human tissues for NOTO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOTO Gene

This gene is overexpressed in Testis (11.1), Small Intestine - Terminal Ileum (6.6), Brain - Hypothalamus (4.3), and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NOTO Gene

SOURCE GeneReport for Unigene cluster for NOTO Gene Hs.694384

genes like me logo Genes that share expressions with NOTO: view

No data available for mRNA Expression by UniProt/SwissProt for NOTO Gene

Orthologs for NOTO Gene

This gene was present in the common ancestor of animals.

Orthologs for NOTO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOTO 35
  • 99.2 (n)
  • 99.2 (a)
NOTO 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOTO 35
  • 76.93 (n)
  • 64.8 (a)
NOTO 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOTO 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noto 35
  • 68.9 (n)
  • 59.37 (a)
Noto 16
Noto 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noto 35
  • 69.96 (n)
  • 57.85 (a)
chicken
(Gallus gallus)
Aves GNOT1 36
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397961 35
zebrafish
(Danio rerio)
Actinopterygii flh 36
  • 24 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18599 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for NOTO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOTO Gene

ENSEMBL:
Gene Tree for NOTO (if available)
TreeFam:
Gene Tree for NOTO (if available)

Paralogs for NOTO Gene

Paralogs for NOTO Gene

Selected SIMAP similar genes for NOTO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NOTO: view

Variants for NOTO Gene

Sequence variations from dbSNP and Humsavar for NOTO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1864490 -- 73,208,259(-) AGTGC(A/C)AGAAG intron-variant
rs1864491 -- 73,208,091(-) TTCCT(C/T)TCCTT intron-variant
rs1864492 - 73,202,680(-) GCGGC(C/G)TGGGG missense, reference
rs2060003 -- 73,205,695(-) accac(C/T)gcact intron-variant
rs4852914 -- 73,207,437(+) TCCCT(C/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOTO Gene

Variant ID Type Subtype PubMed ID
esv2388236 CNV Deletion 18987734
esv2720204 CNV Deletion 23290073
esv2668838 CNV Deletion 23128226
nsv2776 CNV Loss 18451855

Relevant External Links for NOTO Gene

HapMap Linkage Disequilibrium report
NOTO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTO Gene

Disorders for NOTO Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NOTO Gene including...

Search for NOTO Gene in MalaCards »

(2) University of Copenhagen DISEASES for NOTO Gene

genes like me logo Genes that share disorders with NOTO: view

No data available for UniProtKB/Swiss-Prot for NOTO Gene

Publications for NOTO Gene

  1. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. (PMID: 15231714) Abdelkhalek H.B. … Gossler A. (Genes Dev. 2004) 2 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for NOTO Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NOTO
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NOTO
  • Block miRNA regulation of NOTO using miScript Target Protectors

Sources for NOTO Gene

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