Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NOTO Gene

Aliases for NOTO Gene

  • Notochord Homeobox 2 3 5
  • Notochord Homolog (Xenopus Laevis) 2

External Ids for NOTO Gene

Previous GeneCards Identifiers for NOTO Gene

  • GC02P073341
  • GC02P073283
  • GC02P073429
  • GC02P073165

Summaries for NOTO Gene

GeneCards Summary for NOTO Gene

NOTO (Notochord Homeobox) is a Protein Coding gene. Diseases associated with NOTO include Diphyllobothriasis. An important paralog of this gene is EMX1.

UniProtKB/Swiss-Prot for NOTO Gene

  • Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOTO Gene

Genomics for NOTO Gene

Regulatory Elements for NOTO Gene

Enhancers for NOTO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073175 1.3 FANTOM5 Ensembl ENCODE 11.6 -25.6 -25604 3.2 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SMYD5 SFXN5 DUSP11 PRADC1 ENSG00000273245 NOTO SPR EMX1 CCT7 EGR4
GH02F073202 0.2 Ensembl 0.8 +0.6 615 1.7 RNF2 SUZ12 POLR2A CTBP2 THRB RXRB EZH2 PRADC1 SMYD5 NOTO
GH02F073191 0.9 ENCODE 0.4 -10.4 -10392 1.5 ARID4B RAD21 DNMT3B RARA ZNF366 THAP11 NFYC CEBPB ETV4 CEBPA SMYD5 RAB11FIP5 PRADC1 SFXN5 SPR EMX1 CCT7 GC02P073186 NOTO
GH02F073212 0.7 ENCODE 0.4 +10.6 10601 0.7 ELF3 ARID4B DMAP1 ZNF48 RAD21 ZNF121 SLC30A9 SCRT2 ZNF143 THAP11 PRADC1 CCT7 RAB11FIP5 SFXN5 SPR SMYD5 NOTO
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NOTO on UCSC Golden Path with GeneCards custom track

Genomic Location for NOTO Gene

Chromosome:
2
Start:
73,202,258 bp from pter
End:
73,212,513 bp from pter
Size:
10,256 bases
Orientation:
Plus strand

Genomic View for NOTO Gene

Genes around NOTO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOTO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOTO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTO Gene

Proteins for NOTO Gene

  • Protein details for NOTO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTQ0-NOTO_HUMAN
    Recommended name:
    Homeobox protein notochord
    Protein Accession:
    A8MTQ0
    Secondary Accessions:
    • B4DJ59
    • B7ZAU5

    Protein attributes for NOTO Gene

    Size:
    251 amino acids
    Molecular mass:
    27003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOTO Gene

Post-translational modifications for NOTO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOTO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOTO Gene

Domains & Families for NOTO Gene

Gene Families for NOTO Gene

Protein Domains for NOTO Gene

Suggested Antigen Peptide Sequences for NOTO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MTQ0

UniProtKB/Swiss-Prot:

NOTO_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with NOTO: view

Function for NOTO Gene

Molecular function for NOTO Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity).

Gene Ontology (GO) - Molecular Function for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NOTO: view
genes like me logo Genes that share phenotypes with NOTO: view

Animal Models for NOTO Gene

MGI Knock Outs for NOTO:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOTO Gene

Localization for NOTO Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTO Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOTO Gene COMPARTMENTS Subcellular localization image for NOTO gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NOTO: view

Pathways & Interactions for NOTO Gene

SuperPathways for NOTO Gene

No Data Available

Interacting Proteins for NOTO Gene

Gene Ontology (GO) - Biological Process for NOTO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007368 determination of left/right symmetry IEA --
genes like me logo Genes that share ontologies with NOTO: view

No data available for Pathways by source and SIGNOR curated interactions for NOTO Gene

Transcripts for NOTO Gene

mRNA/cDNA for NOTO Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOTO Gene

Notochord homeobox:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOTO Gene

No ASD Table

Relevant External Links for NOTO Gene

GeneLoc Exon Structure for
NOTO
ECgene alternative splicing isoforms for
NOTO

Expression for NOTO Gene

mRNA expression in normal human tissues for NOTO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOTO Gene

This gene is overexpressed in Testis (x11.1), Small Intestine - Terminal Ileum (x6.6), Brain - Hypothalamus (x4.3), and Colon - Transverse (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOTO Gene



NURSA nuclear receptor signaling pathways regulating expression of NOTO Gene:

NOTO

SOURCE GeneReport for Unigene cluster for NOTO Gene:

Hs.694384
genes like me logo Genes that share expression patterns with NOTO: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NOTO Gene

Orthologs for NOTO Gene

This gene was present in the common ancestor of animals.

Orthologs for NOTO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOTO 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia NOTO 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOTO 34 35
  • 76.93 (n)
rat
(Rattus norvegicus)
Mammalia Noto 34
  • 69.96 (n)
mouse
(Mus musculus)
Mammalia Noto 34 16 35
  • 68.9 (n)
chicken
(Gallus gallus)
Aves GNOT1 35
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397961 34
zebrafish
(Danio rerio)
Actinopterygii flh 35
  • 24 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18599 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for NOTO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOTO Gene

ENSEMBL:
Gene Tree for NOTO (if available)
TreeFam:
Gene Tree for NOTO (if available)

Paralogs for NOTO Gene

Paralogs for NOTO Gene

(4) SIMAP similar genes for NOTO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NOTO: view

Variants for NOTO Gene

Sequence variations from dbSNP and Humsavar for NOTO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10164870 -- 73,203,835(+) gtggc(G/T)cacgc intron-variant
rs10171459 -- 73,207,600(+) CCAGG(A/C)TGGAG intron-variant
rs10175626 -- 73,203,413(+) CGCTT(A/G)GTGAC intron-variant
rs10184355 -- 73,211,145(+) GGCCA(A/T)CCTAT utr-variant-3-prime
rs10193012 -- 73,201,821(+) GAAAA(C/G)TGATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NOTO Gene

Variant ID Type Subtype PubMed ID
esv2388236 CNV deletion 18987734
esv2668838 CNV deletion 23128226
esv3558510 CNV deletion 23714750
nsv2776 CNV deletion 18451855
nsv954190 CNV deletion 24416366

Variation tolerance for NOTO Gene

Gene Damage Index Score: 5.55; 72.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOTO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOTO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTO Gene

Disorders for NOTO Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOTO Gene - From: DISEASES

Disorder Aliases PubMed IDs
diphyllobothriasis
  • diphyllobothrium infection
- elite association - COSMIC cancer census association via MalaCards
Search NOTO in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOTO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOTO
genes like me logo Genes that share disorders with NOTO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOTO Gene

Publications for NOTO Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. (PMID: 15231714) Abdelkhalek H.B. … Gossler A. (Genes Dev. 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for NOTO Gene

Sources for NOTO Gene

Content
Loading form....