V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

NOTCH4 Gene

protein-coding GIFtS: 69

GC06M032270

Notch homolog 4 (Drosophila)
(Previous name: Notch (Drosophila) homolog 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: INT3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ16302 ^²
INT3 ^², ³, ⁵
MGC74442 ^²
NOTCH3 ^²
OTTHUMP00000062678 ^²
hNotch4 ^³
notch4 ^²

Descriptions
Notch (Drosophila) homolog 4 ^¹
Notch 4 ^³
Notch homolog 4 (Drosophila) ^²

External Ids
HGNC: 7884¹
Entrez Gene: 4855²
UniProtKB: Q99466³
Ensembl: ENSG00000204301⁷

Search outside databases for aliases for NOTCH4 gene

Previous GC identifers: GC06M032185 GC06M031933 GC06M032234 GC06M032231

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NOTCH4:

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family

share structural characteristics including an extracellular domain consisting of multiple

epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple,

different domain types. Notch family members play a role in a variety of developmental processes

by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved

intercellular signaling pathway which regulates interactions between physically adjacent cells. In

Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an

intercellular signaling pathway that plays a key role in development. Homologues of the

notch-ligands have also been identified in human, but precise interactions between these ligands

and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi

network, and presented on the cell surface as a heterodimer. This protein functions as a receptor

for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This

gene may be associated with susceptibility to schizophrenia in a small portion of cases. An

alternative splice variant has been described but its biological nature has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466

Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to

regulate cell-fate determination. Upon ligand activation through the released notch intracellular

domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of

the enhancer of split locus. Affects the implementation of differentiation, proliferation and

apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By

similarity)

Gene Wiki entry for NOTCH4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NOTCH4 gene

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3

NOTCH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M032270: (about GC identifiers)

Start:	32,270,598 bp from pter
End:	32,299,822 bp from pter
Size:	29,225 bases
Orientation:	minus strand

2 alternative locations:

Chr6-,c6_QBL 32,263,094-32,292,321

Chr6-,c6_COX 32,258,348-32,287,570

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113896.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466 (See protein sequence)

Recommended Name: Neurogenic locus notch homolog protein 4 precursor

Size: 2003 amino acids; 209622 Da

Subunit: Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are

probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which

act as transcriptional coactivators for NOTCH4

Subcellular location: Cell membrane; Single-pass type I membrane protein

Subcellular location: Notch 4 intracellular domain: Nucleus. Note=Following proteolytical

processing NICD is translocated to the nucleus

Sequence caution: Sequence=BAA09708.1; Type=Frameshift; Positions=1438, 1463;

Secondary accessions: B0V1X5 O00306 Q5SSY7 Q99458 Q99940 Q9H3S8 Q9UII9 Q9UIJ0

Alternative splicing: 3 isoforms: Q99466-1 Q99466-2 Q99466-3 (Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a

furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an

active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal

fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to

yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT).

This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived

peptide containing the intracellular domain (NICD) from the membrane (By similarity)¹

Phosphorylated (By similarity)¹

REFSEQ proteins: NP_004548.3

ENSEMBL proteins:

ENSP00000364163

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NOTCH4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	TAS	8681805
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	11823422
GO:0009925	basal plasma membrane	IEA	--

About this table

Antibodies for NOTCH4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NOTCH4
	Sigma-Aldrich Antibodies for NOTCH4
	R&D Systems Antibodies for NOTCH4 (Notch-4)
	Cell Signaling Technology (CST) Antibodies for NOTCH4
	Antibodies from Abcam (NOTCH4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NOTCH4)
	Novus Biologicals Antibody for NOTCH4

Assays for NOTCH4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99466

ProtoNet protein and cluster: Q99466

4 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000800 LIN-12/notch repeat (LNR) signature

IPB001881 EGF-like calcium-binding

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466

Similarity: Belongs to the NOTCH family

Similarity: Contains 5 ANK repeats

Similarity: Contains 28 EGF-like domains

Similarity: Contains 3 LNR (Lin/Notch) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOTCH4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NOTCH4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004557

Applied Biosystems Silencer® siRNAs for NOTCH4

Sigma-Aldrich siRNA and siRNA Panels for NOTCH4

Sigma-Aldrich shRNA for NOTCH4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004557
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004557
untagged cDNA clone in CMV expression vector: NM_004557

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004557

UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466

Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to

regulate cell-fate determination. Upon ligand activation through the released notch intracellular

domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of

the enhancer of split locus. Affects the implementation of differentiation, proliferation and

apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By

Drosophila Notch homolog 4,mediating cell-cell interactions that specify cell fate during

development,undergoing a first proteolytic cleavage by furin (PACE1) in the Golgi during

trafficking of Notch to the cell surface,undergoing further cleavage by gamma secretase (see

PSEN1) releasing an intracellular domain (NICD) which translocates to the nucleus and modulates

transcription of target genes,homologous to MMTV integration site int-3,containing a (CTG)n

repeats polymorphism,with 2 isoforms L and S

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Notch4):

	embryogenesis	growth/size	homeostasis/metabolism	nervous system
normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	TAS	11823422
GO:0005515	protein binding	IPI	7671825
GO:0046982	protein heterodimerization activity	TAS	8681805
GO:0050785	advanced glycation end-product receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for NOTCH4 (Your Favorite Gene powered by Ingenuity)

Notch Signaling

GeneDecks NOTCH4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NOTCH4

5/22 Interacting proteins for NOTCH4 (ENSP00000364163³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAML1	ENSP00000292599³	STRING (score=.986)
DLL4	ENSP00000249749³	STRING (score=.96)
PSEN1	ENSP00000326366³	STRING (score=.96)
PSEN2	ENSP00000355746³	STRING (score=.96)
RBPJ	ENSP00000354528³	STRING (score=.96)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	ISS	--
GO:0001709	cell fate determination	TAS	11823422
GO:0001763	morphogenesis of a branching structure	ISS	--
GO:0006350	transcription	IEA	--
GO:0007219	Notch signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for NOTCH4:

Inhibitor

Browse Tocris compounds for NOTCH4
1 Novoseek chemical compound relationship for NOTCH4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
snp 2	76.81	3	11239712 (2), 15653273 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOTCH4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NOTCH4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004557

Sigma-Aldrich siRNA and siRNA Panels for NOTCH4

Sigma-Aldrich shRNA for NOTCH4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004557

REFSEQ mRNAs for NOTCH4 gene:

NM_004557.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004557

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004557
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004557
                                 untagged cDNA clone in CMV expression vector: NM_004557

Additional cDNA sequence:

AK131314.1 AK290785.1 AK293692.1 AK294161.1 BC033869.1 BC063815.1 BC140782.1 BC144540.1

BC144541.1 D63395.1 U95299.1

6 DOTS entries:

DT.443558 DT.97785448 DT.40281802 DT.121378239 DT.99962397 DT.91906043

24/222 AceView cDNA sequences (see all 222 ):

AK131314 BU149977 AI244789 BG743359 AJ243938 CR623296 BU163550 BP368231

BQ183096 BU580994 BX089524 BQ023076 AA868548 CA307082 BM705319 CK821917

CD672916 BC018724 BM707893 BU172121 BQ057520 BQ933211 BU617696 CR604341

highest scoring ESTs for NOTCH4:

U95299 AL705835 AL705928 BU146559 CB960724 BF957194 BF994400 BP211398 DA043727 DA441071

Unigene Cluster for NOTCH4:

Notch homolog 4 (Drosophila)

Hs.436100 [show with all ESTs]

Unigene Representative Sequence: NM_004557

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000375023

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NOTCH4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NOTCH4

¹ / ² / ³

6 probe-sets matching NOTCH4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39048_at²^{, 3}	U95-A	1	1.00	1.00	0.86	1.06	U95299	1.00	0.70	0.86	1
57139_at²^{, 3}	U95-C	1	0.75	1.00	0.83	0.95	AI341271	0.60	0.83	0.73	1
205247_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI743713	0.60	0.83	0.73	1
240786_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AI341271	0.60	0.83	0.73	1
205247_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
240786_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks NOTCH4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAGGGAGGA

SOURCE GeneReport for Unigene cluster: Hs.436100
Expression variation in blood from EXPOLDB for NOTCH4
UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466
Tissue specificity: Highly expressed in the heart, moderately in the lung and placenta and at low
levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow
and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NOTCH4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NOTCH4¹	--	Notch homolog 4 (Drosophila)	88.31(n) 88.03(a)	481726 XM_538847.2 XP_538847.2
chimpanzee (Pan troglodytes)	NOTCH4¹	--	Notch homolog 4 (Drosophila)	99.4(n) 99.35(a)	462587 XM_518380.2 XP_518380.2
cow (Bos taurus)	NOTCH4¹	--	Notch homolog 4 (Drosophila)	87.37(n) 87.31(a)	537814 XM_617999.3 XP_617999.2
rat (Rattus norvegicus)	Notch4¹	--	Notch homolog 4 (Drosophila)	82.57(n) 81.24(a)	406162 NM_001002827.1 NP_001002827.1
mouse (Mus musculus)	Notch4^{1, 5}	17 (18.72 cM)⁵	Notch gene homolog 4 (Drosophila)^{1, 5}	83.13(n)¹ 82.29(a)¹	18132¹ NM_010929.2¹ NP_035059.2¹ AB016771⁵ AB016772⁵ (see all 14)

About this table Species with no ortholog for NOTCH4

ENSEMBL Gene Tree for NOTCH4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NOTCH4 gene

CRB2² CRB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: NOTC4_HUMAN, Q99466

Polymorphism: The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number

of Leu varies in the population (from 6 to 12)

10/334 NCBI SNPs in NOTCH4 are shown (see all 334 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 187)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs422951^1,2	A,C,F,H	32296361(-)	`GTGAGA/GCCCAG`	1	T/A	mis¹		26	NA EA MN EU WA NS	3852
	rs9267845^1,2	A,C,F,H	32301676(+)	`ACATTT/AGGAAG`	1	--	ng3¹		12	EU EA WA NA	1182
	rs3096702^1,2	A,C,F,H	32300309(-)	`CCATTC/TGCCAG`	1	--	ng3¹		13	EU EA WA NS	1424
	rs915894^1,2	A,C,F,H	32298368(-)	`AGGCCA/CAGCTT`	1	K/Q	mis¹		15	MN EU EA WA NA	1412
	rs520803^1,2	A,C,F,H	32296581(-)	`CACCAA/C/G/T TGTCA`	3	Q/Q Q/H	syn¹ mis¹		9	EA NA MN EU WA	2152
--	rs2395106^1,2	A,C,F,H	32301198(+)	`cctgcG/Attgca`	1	--	ng3¹		4	EU EA WA	406
	rs397081^1,2	C,F,H,O	32300595(+)	`CCTTCT/CTGAGT`	1	--	ng3¹		12	EA NA MN EU WA	882
	rs3134929^1,2	A,C,F,H	32300085(-)	`GCACAG/CGGCAG`	1	--	ng3¹ tfbs³		8	EU EA WA	832
--	rs520692^1,2	A,C,F,H	32296618(-)	`CCCGGA/GCTGTG`	1	D/G	mis¹ ese³		8	MN EU EA WA NA	842
	rs397596^1,2	C,F,H	32300462(-)	`AAGTGA/GAAACT`	1	--	ng3¹		5	MN EU EA WA	594

About this table

HapMap Linkage Disequilibrium images for NOTCH4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164951

10/13 Novoseek disease relationships for NOTCH4 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	56.74	83	12873802 (6), 12627456 (5), 16894623 (5), 11407996 (5) (see all 26)
mammary tumor	41.75	3	9243759 (1), 15288259 (1)
schizoaffective disorder	27.81	4	11239712 (4)
hepatocellular carcinoma	19.97	8	16951162 (2), 17696940 (1), 17920003 (1), 19304334 (1)
ovarian cancer	14.61	11	18974129 (2), 18632624 (2), 16778208 (1)
breast cancer	12.86	5	17158237 (2), 18339869 (2)
tumors	11.62	30	18339869 (3), 9243759 (3), 16778208 (3), 17675579 (2) (see all 14)
cancer	3.30	6	18184405 (2), 17158237 (1), 15867348 (1), 17804716 (1)
carcinoma	0.00	2	18632624 (1), 17948123 (1)
alzheimers disease	0.00	3	14966150 (2), 17452726 (1)

About this table

Human Gene Mutation Database: NOTCH4
Genetic Association Database: NOTCH4
Human Genome Epidemiology Navigator: NOTCH4 (28 documents)
Tumor Gene Database: NOTCH4

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/145 PubMed articles for NOTCH4 gene (see all 145 ):

Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3. (PubMed id 9168133)^{1, 3, 4} Sugaya K.... Mita K. (1997)
Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples. (PubMed id 12873802)^{1, 3, 6} Takahashi S....Tsuang M.T. (2003)
NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. (PubMed id 11239712)^{1, 3, 6} Ujike H....Kuroda S. (2001)
A NOTCH4 association with multiple sclerosis is secondary to HLA-DR*1501. (PubMed id 14651518)^{1, 3, 6} Duvefelt K....Hillert J. (2004)
NOTCH4 gene haplotype is associated with schizophrenia in African Americans. (PubMed id 14732589)^{1, 3, 6} Luo X....Gelernter J. (2004)
NOTCH4 and the frontal lobe in schizophrenia. (PubMed id 12627456)^{1, 3, 6} Wassink T.H....Andreasen N.C. (2003)
Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits. (PubMed id 12605097)^{1, 3, 6} Carmine A....Olson L. (2003)
The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals. (PubMed id 11407996)^{1, 3, 6} Imai K....Suzuki T. (2001)
Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses. (PubMed id 15653273)^{1, 3, 6} Glatt S.J....Faraone S.V. (2005)
[Association study of NOTCH4 gene polymorphisms with schizophrenia and mood disorders in mixed pedigrees] (PubMed id 16378929)^{1, 3, 6} Wang Z.W....Jing S.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4855	HGNC: 7884	AceView: NOTCH4	Ensembl:ENSG00000204301	euGenes: HUgn4855
ECgene: NOTCH4	H-InvDB: NOTCH4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NOTCH4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NOTCH4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NOTCH4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NOTCH4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NOTCH4		Antibodies for NOTCH4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NOTCH4		Small molecules for NOTCH4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (NOTCH4)
	Chimera RNAi (NOTCH4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NOTCH4

	Recombinant Proteins (NOTCH4)
	Antibodies (NOTCH4)

Search OriGene for NOTCH4

Search Tocris compounds for NOTCH4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NOTCH4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NOTCH4 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

NOTCH4 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for NOTCH4

Summaries
for NOTCH4

Genomic Location
for NOTCH4

Proteins
for NOTCH4

Protein Domains/
Families
for NOTCH4

Gene Function
for NOTCH4

Pathways & Interactions
for NOTCH4

Drugs & Compounds
for NOTCH4

Transcripts
for NOTCH4

Expression
for NOTCH4

Orthologs
for NOTCH4

Paralogs
for NOTCH4

SNPs/Variants
for NOTCH4

Disorders & Mutations
for NOTCH4

Medical News
for NOTCH4

Publications
for NOTCH4

Search for NOTCH4

Genome Databases showing NOTCH4

Other Databases showing NOTCH4

Specialized Databases showing NOTCH4

Licensable Technologies
for NOTCH4

Services
for NOTCH4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NOTCH4 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor NOTCH4

Summariesfor NOTCH4

Genomic Locationfor NOTCH4

Proteinsfor NOTCH4

Protein Domains/Familiesfor NOTCH4

Gene Functionfor NOTCH4

Pathways & Interactionsfor NOTCH4

Drugs & Compoundsfor NOTCH4

Transcriptsfor NOTCH4

Expression for NOTCH4

Orthologsfor NOTCH4

Paralogsfor NOTCH4

SNPs/Variantsfor NOTCH4

Disorders & Mutationsfor NOTCH4

Medical Newsfor NOTCH4

Publicationsfor NOTCH4

Search for NOTCH4

Genome Databases showing NOTCH4

Other Databases showing NOTCH4

Specialized Databases showing NOTCH4

Licensable Technologiesfor NOTCH4

Servicesfor NOTCH4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NOTCH4

Summaries
for NOTCH4

Genomic Location
for NOTCH4

Proteins
for NOTCH4

Protein Domains/
Families
for NOTCH4

Gene Function
for NOTCH4

Pathways & Interactions
for NOTCH4

Drugs & Compounds
for NOTCH4

Transcripts
for NOTCH4

Expression
for NOTCH4

Orthologs
for NOTCH4

Paralogs
for NOTCH4

SNPs/Variants
for NOTCH4

Disorders & Mutations
for NOTCH4

Medical News
for NOTCH4

Publications
for NOTCH4

Licensable Technologies
for NOTCH4

Services
for NOTCH4