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NOTCH3 Gene

protein-coding   GIFtS: 69
GCID: GC19M015270

Notch 3

(Previous names: Notch (Drosophila) homolog 3, Notch homolog 3 (Drosophila))
(Previous symbol: CADASIL)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Notch 31 2 3     Notch (Drosophila) Homolog 31
CADASIL1 2 5     Notch Homolog 3 (Drosophila)1
CASIL2 5     Neurogenic Locus Notch Homolog Protein 32
IMF22 5     Notch Homolog 32

External Ids:    HGNC: 78831   Entrez Gene: 48542   Ensembl: ENSG000000741817   OMIM: 6002765   UniProtKB: Q9UM473   

Export aliases for NOTCH3 gene to outside databases

Previous GC identifers: GC19M015649 GC19M015115 GC19M015131 GC19M014839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOTCH3 Gene:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein
notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an
intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands
have also been identified in human, but precise interactions between these ligands and the human notch homologues
remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal
dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (provided by RefSeq, Jul 2008)

GeneCards Summary for NOTCH3 Gene:
NOTCH3 (notch 3) is a protein-coding gene. Diseases associated with NOTCH3 include myofibromatosis, infantile 2, and balo's concentric sclerosis. GO annotations related to this gene include enzyme binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
the implementation of differentiation, proliferation and apoptotic programs (By similarity)

Gene Wiki entry for NOTCH3 (Notch 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOTCH3 gene promoter:
         AP-2gamma   GATA-2   C/EBPalpha   CHOP-10   Pax-3   COMP1   STAT3   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOTCH3 promoter sequence
   Search Chromatin IP Primers for NOTCH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOTCH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2-p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.2-p13.1

NOTCH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOTCH3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015270:  view genomic region     (about GC identifiers)

Start:
15,270,444 bp from pter      End:
15,311,792 bp from pter
Size:
41,349 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47 (See protein sequence)
Recommended Name: Neurogenic locus notch homolog protein 3 precursor  
Size: 2321 amino acids; 243631 Da
Subunit: Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by
disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators
for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN
Secondary accessions: Q9UEB3 Q9UPL3 Q9Y6L8

Explore the universe of human proteins at neXtProt for NOTCH3: NX_Q9UM47

Explore proteomics data for NOTCH3 at MOPED

Post-translational modifications: 

  • Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like
    convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible
    form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding,
    it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called
    notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to
    release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity)1
  • Phosphorylated (By similarity)1
  • Hydroxylated by HIF1AN1
  • Ubiquitination2 at Lys521, Lys1473, Lys1684
  • Glycosylation2 at Asn1179, Asn1336, Asn1438
  • Modification sites at PhosphoSitePlus

  • See NOTCH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000426.2  
    ENSEMBL proteins: 
     ENSP00000263388   ENSP00000470661   ENSP00000468879   ENSP00000473138  
    Reactome Protein details: Q9UM47

    NOTCH3 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals NOTCH3 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NOTCH3

    NOTCH3 Antibody Products:

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    NOTCH3 Assay Products:

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    Cloud-Clone Corp. ELISAs for NOTCH3
    Cloud-Clone Corp. CLIAs for NOTCH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 14):
     IPR010660 Notch_NOD_dom
     IPR024600 DUF3454_notch
     IPR001881 EGF-like_Ca-bd_dom
     IPR008297 Notch
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UM47

    ProtoNet protein and cluster: Q9UM47

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000800 LIN-12/notch repeat (LNR) signature
    IPB001881 EGF-like calcium-binding
    IPB002049 Laminin-type EGF-like domain
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
    Similarity: Belongs to the NOTCH family
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 34 EGF-like domains
    Similarity: Contains 3 LNR (Lin/Notch) repeats


    NOTCH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOTC3_HUMAN, Q9UM47
    Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
    determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
    transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
    the implementation of differentiation, proliferation and apoptotic programs (By similarity)

         Genatlas biochemistry entry for NOTCH3:
    Drosophila Notch homolog 3,mediating cell-cell interactions that specify cell fate during development,undergoing a
    first proteolytic cleavage by furin (PACE1) in the Golgi during trafficking of Notch to the cell
    surface,undergoing further cleavage by gamma secretase (see PSEN1) releasing an intracellular domain (NICD) which
    translocates to the nucleus and modulates transcription of target genes,putatively involved in translocation with
    acute lymphoblastic/myeloblastic leukemia and in the decision between the endocrine and exocrine fates in the
    developing pancreas

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11101851
    GO:0019899enzyme binding IEA--
         
    NOTCH3 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Notch3) (see all 20):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  nervous system  normal 

    NOTCH3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOTCH3: Notch3tm1Khan Notch3tm1Grid

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOTCH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOTCH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOTCH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOTCH3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOTCH3:
    hsa-mir-1 (MIRT006550), hsa-mir-335-5p (MIRT017387), hsa-mir-484 (MIRT042194), hsa-mir-150-5p (MIRT007016), hsa-mir-206 (MIRT000665)

    Block miRNA regulation of human, mouse, rat NOTCH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOTCH3 (see all 25):
    hsa-miR-26a-2* hsa-miR-875-3p hsa-miR-3673 hsa-miR-136 hsa-miR-520d-5p hsa-miR-1263 hsa-miR-300 hsa-miR-24-1*
    SwitchGear 3'UTR luciferase reporter plasmidNOTCH3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOTCH3
    Predesigned siRNA for gene silencing in human, mouse, rat NOTCH3

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for NOTCH3 (see all 5)
    OriGene ORF clones in mouse, rat for NOTCH3
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    GenScript: all cDNA clones in your preferred vector: NOTCH3 (NM_000435)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTCH3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NOTCH3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NOTCH3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOTC3_HUMAN, Q9UM47: Cell membrane; Single-pass type I membrane protein
    NOTC3_HUMAN, Q9UM47: Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is
    translocated to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    endoplasmic reticulum4
    extracellular4
    golgi apparatus4
    cytoskeleton1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    NOTCH3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOTCH3 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling0.30
    Notch Signaling Pathway0.84
    Signaling by NOTCH30.00
    Delta-Notch Signaling Pathway0.33
    2Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Notch-HLH transcription pathway0.00
    Pre-NOTCH Transcription and Translation0.62
    Pre-NOTCH Processing in the Endoplasmic Reticulum0.00
    Pre-NOTCH Processing in Golgi0.00
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOTCH3
        Notch Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOTCH3
        Notch Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for NOTCH3
        Wnt / Hedgehog / Notch
    Angiogenesis
    Neuroscience

    4 BioSystems Pathways for NOTCH3
        Notch Signaling Pathway
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    Notch signaling pathway

    5 Reactome Pathways for NOTCH3
        Pre-NOTCH Processing in Golgi
    Pre-NOTCH Transcription and Translation
    Notch-HLH transcription pathway
    Pre-NOTCH Processing in the Endoplasmic Reticulum
    Signaling by NOTCH3


    4 Kegg Pathways  (Kegg details for NOTCH3):
        Dorso-ventral axis formation
    Notch signaling pathway
    Thyroid hormone signaling pathway
    MicroRNAs in cancer


    NOTCH3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH3: 
              Notch Signaling Targets in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOTCH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOTCH3 (Q9UM471, 2, 3 ENSP000002633884) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253473 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253473 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0007220Notch receptor processing TAS--
    GO:0007275multicellular organismal development ----

    NOTCH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOTCH3 (NOTC3)

    3 Novoseek inferred chemical compound relationships for NOTCH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 58.1 29 19043263 (2), 16256149 (2), 15714997 (1), 17331978 (1) (see all 18)
    arginine 14.1 3 15714997 (1), 11559313 (1)
    calcium 1.73 1 10024441 (1)



    NOTCH3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOTCH3 gene: 
    NM_000435.2  

    Unigene Cluster for NOTCH3:

    Notch 3
    Hs.8546  [show with all ESTs]
    Unigene Representative Sequence: U97669
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263388(uc002nan.3 uc002nao.1) ENST00000595514 ENST00000597756
    ENST00000601011 ENST00000600841 ENST00000595045

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NOTCH3 (see all 25):
    hsa-miR-26a-2* hsa-miR-875-3p hsa-miR-3673 hsa-miR-136 hsa-miR-520d-5p hsa-miR-1263 hsa-miR-300 hsa-miR-24-1*
    SwitchGear 3'UTR luciferase reporter plasmidNOTCH3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NOTCH3 (NM_000435)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NOTCH3
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      QuantiTect SYBR Green Assays in human, mouse, rat NOTCH3
      QuantiFast Probe-based Assays in human, mouse, rat NOTCH3

    Additional mRNA sequence: 

    AB209447.1 U97669.1 

    5 DOTS entries:

    DT.217396  DT.91963540  DT.100815125  DT.75121130  DT.91646701 

    Selected AceView cDNA sequences (see all 277):

    BI523794 BU553672 BQ919557 AI274902 T63511 BE764071 BI052410 CA433198 
    BF435534 CA446395 AW194070 AI091531 AI559175 AI473478 AI921030 AA301460 
    BU846477 BU956081 BM841037 CK904462 AI969777 BM021466 CB270591 CN483616 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOTCH3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^
    SP1:                                                                                                                    -                                       
    SP2:                                                                                      -                             -                                       
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for NOTCH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOTCH3 expression in normal human tissues (normalized intensities)      NOTCH3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAATAGA
    NOTCH3 Expression
    About this image


    NOTCH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 40 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 32 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Myoblasts Forelimb Ventral Muscles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    NOTCH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOTCH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8546

    UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
    Tissue specificity: Ubiquitously expressed in fetal and adult tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH3: 
              Notch Signaling Targets in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOTCH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOTCH3
    QuantiTect SYBR Green Assays in human, mouse, rat NOTCH3
    QuantiFast Probe-based Assays in human, mouse, rat NOTCH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NOTCH3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Notch31 , 5 Notch gene homolog 3 (Drosophila)5
    notch 31
    84.32(n)1
    90.99(a)1
      17 (17.37 cM)5
    181311  NM_008716.21  NP_032742.11 
     321208205 
    lizard
    (Anolis carolinensis)
    Reptilia NOTCH36
    notch 3
    63(a)
    1 ↔ 1
    2(103176116-103239023)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420334872   -- 76.95(n)    142033487 
    zebrafish
    (Danio rerio)
    Actinopterygii AF152001.12   -- 75.66(n)   58066  AF152001.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SP10703 Notch binding 38(a)
    (best of 2)
      27D2   --


    ENSEMBL Gene Tree for NOTCH3 (if available)
    TreeFam Gene Tree for NOTCH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for NOTCH3 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  DLL42  JAG22  CRB22  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    Selected SIMAP similar genes for NOTCH3 using alignment to 5 protein entries:     NOTC3_HUMAN (see all proteins) (see all similar genes):
    F9 p22    factor IX F9    CRB1    F9    SVEP1    SLIT3
    NOTCH2    PPP1R12A    SLIT2    FBLN7    NOTCH1    PROS1
    VCAN    DLL3    ACAN    GABPB1    SNED1    ANKRD44

    NOTCH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NOTCH3 (see all 1322)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011180341,2,,4
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 --15229476(+) GTTGCA/GATCAC 2 R C mis10--------
    rs289336981,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115231165(-) TCACCC/TGTATC 2 R C mis1 ese30--------
    rs289336971,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115234256(-) CCTTCC/TGCTGC 2 R C mis1 ese30--------
    rs289336961,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115234295(-) CCTGCC/TGCCAT 2 R C mis1 ese30--------
    VAR_0443044
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443042 C Y mis40--------
    VAR_0442344
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442342 C S mis40--------
    VAR_0128904
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128902 C Y mis40--------
    VAR_0128964
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128962 R C mis40--------
    VAR_0442864
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442862 C R mis40--------
    VAR_0443134
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443132 C R mis40--------
    VAR_0442694
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442692 C S mis40--------
    VAR_0442614
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442612 C S mis40--------
    VAR_0442924
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442922 C S mis40--------
    VAR_0442504
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442502 C Y mis40--------
    VAR_0442524
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442522 C W mis40--------
    VAR_0128734
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128732 R C mis40--------
    VAR_0443154
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443152 Y C mis40--------
    VAR_0443164
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443162 D C mis40--------
    VAR_0442974
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442972 C Y mis40--------
    VAR_0442674
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442672 C F mis40--------
    VAR_0442484
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442482 S C mis40--------
    VAR_0128794
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128792 R C mis40--------
    VAR_0442774
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442772 C Y mis40--------
    VAR_0442514
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442512 C Y mis40--------
    VAR_0442354
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442352 C Y mis40--------
    VAR_0443004
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443002 C S mis40--------
    VAR_0442804
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442802 C Y mis40--------
    VAR_0442404
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442402 C R mis40--------
    VAR_0128934
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128932 R C mis40--------
    VAR_0442824
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442822 C Y mis40--------
    VAR_0442754
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442752 C Y mis40--------
    VAR_0442334
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442332 S C mis40--------
    VAR_0442954
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442952 R C mis40--------
    VAR_0128854
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128852 C S mis40--------
    VAR_0442564
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442562 C Y mis40--------
    VAR_0442994
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442992 C R mis40--------
    VAR_0442624
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442622 C S mis40--------
    VAR_0442574
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442572 S C mis40--------
    VAR_0442364
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442362 C R mis40--------
    VAR_0442464
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442462 C Y mis40--------
    VAR_0442554
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442552 C S mis40--------
    VAR_0442664
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442662 S C mis40--------
    VAR_0442644
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442642 C R mis40--------
    VAR_0128884
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128882 Y C mis40--------
    VAR_0442814
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442812 C S mis40--------
    VAR_0443084
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443082 C Y mis40--------
    VAR_0442964
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442962 C S mis40--------
    VAR_0442944
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442942 G C mis40--------
    VAR_0442684
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442682 C R mis40--------
    VAR_0442304
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442302 C G mis40--------
    VAR_0443014
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443012 R C mis40--------
    VAR_0129004
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0129002 C R mis40--------
    VAR_0442874
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442872 C Y mis40--------
    VAR_0442584
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442582 G C mis40--------
    VAR_0442324
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442322 R C mis40--------
    VAR_0443034
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443032 C F mis40--------
    VAR_0443054
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443052 C Y mis40--------
    VAR_0442984
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442982 C G mis40--------
    VAR_0443064
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443062 C R mis40--------
    VAR_0442764
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442762 C Y mis40--------
    VAR_0128784
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128782 C R mis40--------
    VAR_0442634
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442632 C F mis40--------
    VAR_0442444
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442442 C W mis40--------
    VAR_0128874
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128872 C Y mis40--------
    VAR_0699274
    Myofibromatosis, infantile 2 (IMF2)4--see VAR_0699272 L P mis40--------
    VAR_0443104
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443102 C S mis40--------
    VAR_0442494
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442492 C F mis40--------
    VAR_0442654
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442652 C Y mis40--------
    VAR_0442734
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442732 C R mis40--------
    VAR_0442454
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442452 C W mis40--------
    VAR_0442724
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442722 C F mis40--------
    VAR_0442904
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442902 S C mis40--------
    VAR_0442534
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442532 F C mis40--------
    VAR_0128944
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128942 R C mis40--------
    VAR_0443094
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443092 R C mis40--------
    VAR_0442854
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442852 C R mis40--------
    VAR_0442794
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442792 R K mis40--------
    VAR_0442314
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442312 C F mis40--------
    VAR_0442594
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442592 Y C mis40--------
    VAR_0442424
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442422 C F mis40--------
    VAR_0442844
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442842 C S mis40--------
    VAR_0442714
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442712 Y C mis40--------
    VAR_0128824
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128822 G C mis40--------
    VAR_0442934
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442932 C R mis40--------
    VAR_0442784
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442782 R C mis40--------
    VAR_0443174
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443172 C Y mis40--------
    VAR_0443124
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443122 F C mis40--------
    VAR_0128714
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128712 C Y mis40--------
    VAR_0442894
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442892 R C mis40--------
    VAR_0442914
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442912 Y C mis40--------
    VAR_0442434
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442432 C Y mis40--------
    VAR_0128914
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128912 R C mis40--------
    VAR_0128864
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128862 C G mis40--------
    VAR_0442374
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442372 C W mis40--------
    VAR_0442474
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442472 C F mis40--------
    VAR_0442744
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442742 C S mis40--------
    VAR_0442704
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442702 C G mis40--------
    VAR_0128954
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128952 R C mis40--------
    VAR_0128994
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128992 R C mis40--------
    VAR_0442544
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442542 C F mis40--------
    VAR_0128844
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128842 C R mis40--------
    VAR_0442884
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442882 A C mis40--------
    VAR_0128924
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128922 R C mis40--------
    VAR_0128774
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128772 R C mis40--------
    VAR_0128764
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128762 R C mis40--------
    VAR_0442414
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442412 C Y mis40--------
    VAR_0443114
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443112 G C mis40--------
    VAR_0128744
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128742 R C mis40--------
    rs1447084611,2
    Cuntested115216344(+) GCGCAG/AGATGG 2 /L syn11Minor allele frequency- A:0.00NA 2970
    rs1380929381,2
    Cuntested115221028(+) GACCCG/AGGCTA 2 /P /L mis11Minor allele frequency- A:0.00NA 3818
    rs357699761,2,,4
    C,Funknown115222927(-) ATAGGG/CCCCAG 2 /P /A mis111Minor allele frequency- C:0.22NA WA EU 5179
    rs1912832271,2
    --15201238(+) ACTCAA/CTTAAC 1 -- ds50010--------
    rs1838637211,2
    --15201270(+) GAGCCA/GAGATA 1 -- ds50010--------
    rs48090261,2
    C,F,A--15201294(+) TCAAGG/CAGCCA 1 -- ds50019Minor allele frequency- C:0.22NA CSA WA EA 369
    rs1391555221,2
    C--15201384(+) TCGAAC/TTGGCC 1 -- ds50010--------
    rs1499498001,2
    --15201467(+) AGAAAA/GTTCTC 1 -- ds50010--------
    rs1895595461,2
    --15201473(+) TTCTCA/GAGCAA 1 -- ds50010--------
    rs1820303051,2
    --15201528(+) CCAATC/TGGTAG 1 -- ds50010--------
    rs1876431371,2
    --15201536(+) TAGTCA/GTCTGC 1 -- ds50010--------
    rs116700451,2
    C,H--15201537(+) AGTCAC/TCTGCC 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs169803781,2
    C,F,H--15201771(+) TGACCA/GGAAGC 1 -- ut31 ese316Minor allele frequency- G:0.04NA NS EA 1540
    rs10441231,2
    C,F,A,H--15201818(-) AGCCTT/CATGGC 1 -- ut31 ese325Minor allele frequency- C:0.42MN NA NS EA WA CSA 2668
    rs120821,2
    C,F,A,H--15201871(-) AAGAAG/AAGGAG 1 -- ut31 ese3 trp323Minor allele frequency- A:0.06MN NA NS EA 2248
    rs10441161,2
    C,F,A,H--15201900(-) CCTTTA/GTGTCC 1 -- ut31 ese326Minor allele frequency- G:0.42MN NA NS EA WA CSA 2672
    rs1899698771,2
    --15202035(+) GAACAC/TGTCCC 1 -- ut310--------
    rs10440551,2
    C,F,A,H--15202040(-) CAGATG/TGGACA 1 -- ut31 ese328Minor allele frequency- N:0.00MN EA NA NS WA 2793
    rs797943521,2
    C--15202123(+) GTGCGA/CCCAAG 1 -- ut310--------
    rs776699831,2
    C,F--15202145(+) GGTACA/G/TTACCT 2 -- ut313NA CSA 123
    rs1450959991,2
    --15202245(+) CCCCAC/TGGGGG 1 -- ut310--------
    rs1397920651,2
    --15202338(+) TTTGTC/TTCTAT 1 -- ut310--------
    rs72479061,2
    C,H--15202370(+) AAAAAG/TAAAAA 1 -- ut317Minor allele frequency- T:0.11NA WA CSA EA 364
    rs1819309341,2
    --15202402(+) AGAGTA/GTAAGG 1 -- ut310--------
    rs1171657441,2
    C,F--15202612(+) AAGAGG/AATGAA 1 -- ut311Minor allele frequency- A:0.02NA 120
    rs1853103761,2
    C--15202623(+) AAAGAA/CTAAAA 1 -- ut310--------
    rs1901714361,2
    --15202630(+) AAAAGA/GAAGGA 1 -- ut310--------
    rs735040841,2
    C--15202685(+) CCCCAT/AGATCT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1821116551,2
    C--15202704(+) ACGAGC/TGTCTC 1 -- ut310--------
    rs2021574551,2
    C,F--15202705(+) CGAGCG/ATCTCA 1 -- ut311Minor allele frequency- A:0.00EU 1299
    rs794476911,2
    C--15202809(+) CTGGGC/GAGGCA 2 P A mis10--------
    rs617319741,2
    C,F--15202861(+) GGGCTA/GGGCGT 2 P syn13Minor allele frequency- G:0.02NS WA NA 4536
    rs1487169351,2
    C--15202865(+) TAGGCG/ATGGAT 2 /T /M mis11Minor allele frequency- A:0.00NA 4422
    rs2010736421,2
    --15202919(+) GCTCAG/TGGGAT 2 H P mis10--------
    rs617319751,2
    C,F--15202921(+) TCAGGA/C/GGATTC 3 S syn14NS CSA WA NA 4243
    rs1849965451,2
    --15202974(+) GAAGCA/GGGCCT 2 R C mis10--------
    rs129762681,2
    C--15202978(+) CGGGCC/TTTTGG 2 K syn1 ese33Minor allele frequency- T:0.00NA EA 322
    rs1911735591,2
    --15203005(+) CCAGCA/CGCCGG 2 A syn10--------
    rs10440091,2,,4
    C,F,H--15203006(-) CCCGGT/CGGCTG 2 /A /V mis1 ese326Minor allele frequency- C:0.41EA MN NA NS WA CSA 4193
    rs1466793271,2
    --15203050(+) GGCGGA/GGGCCG 2 P syn10--------
    rs2004156791,2
    --15203071(+) GAGACA/GGGGGT 2 P syn10--------
    rs10440081,2
    C,F--15203236(-) CGGGCG/AGGTCT 2 /A syn1 ese31Minor allele frequency- A:0.03NA 120
    rs1838397951,2
    --15203374(+) ACGGGC/TGACAG 2 S syn10--------
    rs1144473501,2
    C,F--15203453(+) CCTGCG/AGCCCC 2 /P /L mis11Minor allele frequency- A:0.08WA 118
    rs1892524351,2
    --15203472(+) CTTCCC/TGGGGG 2 R G mis10--------
    rs1148875701,2
    C,F--15203572(+) GGACCG/AGGGGG 2 /P syn11Minor allele frequency- A:0.03WA 118
    rs1996204761,2
    C--15203613(+) GCGCAC/TGATGT 2 M V mis10--------
    rs1420075751,2
    C--15203643(-) GGGACG/ATAGCC 2 /I /V mis11Minor allele frequency- A:0.00EU 511
    rs2011053351,2
    C--15203682(+) CTCACA/GGTTGG 2 R C mis10--------
    rs2006404061,2
    --15203795(+) GAAACC/TCCAGC 1 -- int10--------
    rs763894471,2
    C,F--15203849(+) CTATGA/TGTTTG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1143774851,2
    C,F--15203888(+) AATCCC/TGGCTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs735040881,2
    C,F--15203968(+) TCAAGG/ACCAGG 1 -- int11Minor allele frequency- A:0.14WA 118
    rs711685831,2
    C--15204029(+) TTTTT-/TGACAG 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1928140721,2
    --15204152(+) CCTCCC/TGAGCA 1 -- int10--------
    rs65120171,2
    C,A,H--15204178(+) GTGCAT/CCACTA 1 -- int111Minor allele frequency- C:0.05NA WA CSA 19
    rs7574711,2
    C,A,H--15204282(+) CTCGAT/CCTCCC 1 -- int110Minor allele frequency- C:0.00NA WA CSA 22
    rs1502599881,2
    --15204389(+) TTTTAA/TTCCAA 1 -- int10--------
    rs1830798941,2
    --15204403(+) TTGGGA/GTTTTA 1 -- int10--------
    rs7574721,2
    C,F,A,H--15204456(+) CTGGAC/TTGCAA 1 -- int115Minor allele frequency- T:0.22MN NA WA CSA EA 566
    rs1997359031,2
    C--15204465(+) AATGGC/TACTGT 1 -- int10--------
    rs48090281,2
    C,F,A,H--15204466(+) ATGGCG/ACTGTG 1 -- int116Minor allele frequency- A:0.09NA WA CSA EA 519
    rs48090291,2
    C,F,A,H--15204483(+) CTGACC/ACCCAG 1 -- int119Minor allele frequency- A:0.11NA EA WA CSA EU 1382
    rs1405671001,2
    F--15204529(+) ATGTCC/TTTATT 2 K syn11Minor allele frequency- T:0.00NA 4550
    rs1155822131,2
    C,F--15204570(+) TTCCAC/TGTTGT 2 M V mis13Minor allele frequency- T:0.01EU NA 5999
    rs1870581471,2
    C--15204614(+) CTGGAA/GGATGA 1 -- int10--------
    rs48090301,2
    C,F,A,H--15204616(+) GGAGGG/ATGAAG 1 -- int132Minor allele frequency- A:0.12NA NS EA WA CSA EU 4038
    rs2016008671,2
    --15204642(+) ACCAGG/TCACCT 1 -- int10--------
    rs1137428241,2
    C,F--15204659(+) GGGCCC/TCCATG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1470298521,2
    --15204775(+) AAAATC/GACTCT 1 -- int10--------
    rs1156663281,2
    F--15204785(+) TGTGCA/GATGGG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs2010777661,2
    --15204804(+) TTGTG-/TCTGTGT 1 -- int10--------
    rs766034701,2
    F--15204805(+) TGTGTG/CTGTGT 1 -- int11Minor allele frequency- C:0.50NA 4
    rs1399662301,2
    C--15204812(+) GTGTG-/TGT   
       GTGTT
    TGTGT
    1 -- int10--------
    rs1468134861,2
    --15204816(+) GTGTG-/TGTT  
            
    TGTGT
    1 -- int10--------
    rs48090311,2
    C,A--15204819(+) TGTGTG/TTGTGT 1 -- int15Minor allele frequency- T:0.00WA NA CSA 8
    rs58272781,2
    C--15204819(+) tgtgt-/TTGT/ 
    TTGTGTGT
    gtgtg
    1 -- int11NA 2
    rs7574731,2
    C,A,H--15204840(+) GTGTGT/CGTGCA 1 -- int14Minor allele frequency- C:0.00NA CSA 6
    rs7574741,2
    C,F,H--15204859(+) ACTGTC/TTATAC 1 -- int122Minor allele frequency- T:0.10NA EA NS WA CSA 1130
    rs1176808091,2
    C,F--15204939(+) CATGTG/AGTTTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1916919121,2
    --15204952(+) TTTATA/CCATTT 1 -- int10--------
    rs7574751,2
    C,A,H--15204984(+) TTGTTT/CTGTCA 1 -- int113Minor allele frequency- C:0.10NA WA CSA EA 376
    rs1383285201,2
    C--15205084(+) AGCTGA/GGACTA 1 -- int10--------
    rs1438956321,2
    --15205240(+) GCCACC/TGTGCC 1 -- int10--------
    rs1442967071,2
    C--15205241(+) CCACCA/GTGCCC 1 -- int10--------
    rs755222371,2
    C--15205339(+) GTGCTA/GGAACA 1 -- int10--------
    rs104067541,2
    C,H--15205436(+) atataA/Tgagct 1 -- int114Minor allele frequency- T:0.10NA WA CSA EA 377
    rs1842874871,2
    --15205452(+) TATAGA/GACTAA 1 -- int10--------
    rs1181691241,2
    C,F--15205516(+) ATTCTT/GAGATG 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1163978251,2
    C,F--15205615(+) CTCACG/ACCTAT 1 -- int11Minor allele frequency- A:0.06WA 118
    rs72458141,2
    C,H--15205738(+) caggtG/Atgctg 1 -- int113Minor allele frequency- A:0.10NA WA CSA EA 375
    rs72458501,2
    C,H--15205820(+) TGCAGC/AGAGCC 1 -- int111Minor allele frequency- A:0.00NA WA CSA 21
    rs3751044791,2
    C--15205907(+) TCCATC/TACACA 1 -- int10--------
    rs1891328321,2
    --15205908(+) CCATCA/GACACA 1 -- int10--------
    rs1417406821,2
    --15205956(+) GTGAAA/CCTTGA 1 -- int10--------
    rs104260421,2
    C,F,A,H--15206005(+) accacG/Ctatca 1 -- int127Minor allele frequency- C:0.27NS EA NA CSA WA 2777
    rs1505736131,2
    C--15206092(+) CTGGAC/TAGATG 1 -- int10--------
    rs1928082231,2
    --15206158(+) TGTTCC/TAAAAT 1 -- int10--------
    rs1399710151,2
    --15206173(+) TGTGGC/TAATAG 1 -- int10--------
    rs1853731641,2
    --15206208(+) AGCCAC/TTGAAT 1 -- int10--------
    rs1435126031,2
    --15206250(+) TGTTAA/TTTATA 1 -- int10--------
    rs1115905831,2
    C--15206269(+) AAGCAGTTT    
       TTT
    /-
    GTTTT
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs584889181,2
    C--15206289(+) TTTTT-/TG    
       TTTTT
    AAAAA
    1 -- int11Minor allele frequency- TGTTTTT:0.00NA 2
    rs81039271,2
    C,A,H--15206423(+) tctacA/Taaaaa 1 -- int18Minor allele frequency- T:0.00NA WA CSA 17
    rs81024801,2
    C,F,A,H--15206441(+) aaataT/Gccagg 1 -- int19Minor allele frequency- G:0.24NA WA CSA 138
    rs81071801,2
    C,H--15206664(+) ttgccC/Tcagtc 1 -- int114Minor allele frequency- T:0.09NA WA CSA EA 443
    rs104073201,2
    C,H--15206949(+) tttctC/Ggagta 1 -- int114Minor allele frequency- G:0.09NA WA CSA EA 379
    rs129811581,2
    C,F--15206990(+) TGGCTA/CATCTT 1 -- int111Minor allele frequency- C:0.23NA WA CSA EA 375
    rs1449502841,2
    --15207050(+) TCCTGG/TCCTCA 1 -- int10--------
    rs1490694471,2
    --15207061(+) AGTCAA/TCCTCC 1 -- int10--------
    rs1479371381,2
    C--15207142(+) TATAAC/TAACTT 1 -- int10--------
    rs735041001,2
    C,F--15207174(+) TGTCCG/ATCTAA 1 -- int12Minor allele frequency- A:0.02WA 120
    rs28866981,2
    C,F,A,H--15207240(-) TTAGGT/GTGCCT 1 -- int115Minor allele frequency- G:0.37NS EA NA WA CSA 764
    rs20746171,2
    C,A--15207288(+) TGAAGG/CCTGGT 1 -- int113Minor allele frequency- C:0.09NA WA CSA EA 379
    rs1418390141,2
    --15207346(+) TTGCAA/CCAACA 1 -- int10--------
    rs1471178961,2
    --15207356(+) ATGACA/CCTCAG 1 -- int10--------
    rs20746181,2
    C,F--15207376(+) GACACT/CAACCC 1 -- int116Minor allele frequency- C:0.12EA NA WA CSA EU 2049
    rs1148130861,2
    --15207463(+) TTCCAC/ACATGC 2 /V /L mis11Minor allele frequency- A:0.01EA 198
    rs2010712481,2
    --15207468(+) CCATGC/TCCTCT 2 D G mis10--------
    rs1132301291,2
    C--15207562(+) AATCTA/GGGACA 1 -- int10--------
    rs1431713771,2
    C--15207855(+) CGGCT-/GGGG  
            
    GTGAC
    2 A PS fra10--------
    rs761665181,2
    C--15207857(+) GGCTGG/TGACAG 2 T P mis10--------
    rs2001030091,2
    --15207873(+) TGCAGA/GGGAGT 2 P syn10--------
    rs2008832351,2
    C--15207928(+) GCAGCC/TGCTTG 2 Q R mis11Minor allele frequency- T:0.00EU 1119
    rs169803981,2
    C,F,H--15207972(+) TGCAAA/GGCAGT 2 A syn1 ese328Minor allele frequency- G:0.13NA NS EA WA CSA EU 8609
    rs1382658941,2
    C--15207988(+) CAGTAC/TGGTCA 2 H R mis11Minor allele frequency- T:0.00NA 4546
    rs1423435051,2
    C--15207990(+) GTACGA/GTCAGT 2 D syn10--------
    rs2020276321,2
    C--15207997(+) CAGTCC/TGTGCC 2 Q R mis10--------
    rs1480530281,2
    C--15208032(+) AGGTCG/AGAGAT 2 /S syn11Minor allele frequency- A:0.00NA 4550
    rs1146610661,2
    C,F--15208038(+) GAGATG/TATGCT 2 I syn12Minor allele frequency- T:0.01EA NA 428
    rs344803081,2
    C,F--15208098(+) GCCCCC/ACCACA 2 /G syn15Minor allele frequency- A:0.01NA WA 5176
    rs3748750841,2
    C--15208122(+) ATTAGC/TGGGGT 2 P syn10--------
    rs358874161,2
    C,F--15208128(+) GGGGTG/AAAGCC 2 /F syn16Minor allele frequency- A:0.00NA CSA WA 5164
    rs20746191,2
    C,F,A,H--15208152(+) GGAGTA/GTGTCA 1 -- int116Minor allele frequency- G:0.13EA NA WA CSA EU 2416
    rs104167771,2
    C,F,A--15208156(+) TGTGTT/CAGCAG 1 -- int115Minor allele frequency- C:0.11NA WA CSA EA EU 1124
    rs1162161911,2
    C,F--15208175(+) ACACAG/AGGCCT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs3768375551,2
    C--15208237(+) GAAAA-/ACGATGAC 2 -- int1 cds10--------
    rs455919351,2
    C--15208239(+) AAAAAC/TGACAA 1 -- int19Minor allele frequency- T:0.10NA WA CSA EA 369
    rs621137911,2
    C--15208242(+) AATGAT/CAATTA 1 -- int14Minor allele frequency- C:0.11NA WA EA 360
    rs455043931,2
    C--15208243(+) ATGACG/AATTAG 1 -- int14Minor allele frequency- A:0.11NA WA EA 360
    rs104154311,2
    C,H--15208260(+) CTCCTA/GTCTGC 1 -- int114Minor allele frequency- G:0.09NA WA CSA EA 379
    rs803532221,2
    --15208298(+) GGGCAC/TGTGAT 1 -- int10--------
    rs1151167681,2
    F--15208299(+) GGCACG/ATGATT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs72502321,2
    C,F,A,H--15208432(+) TGGAAT/CATGTG 1 -- int127Minor allele frequency- C:0.11NA NS EA WA CSA 2486
    rs587060681,2
    C--15208446(+) TACCC-/CAAGAGT 1 -- int10--------
    rs116720041,2
    C,F,A,H--15208515(+) GGAGCA/TGCCCC 1 -- int119Minor allele frequency- N:0.00EA NA NS CSA WA 972
    rs72495251,2
    C,H--15208542(+) TGAGTA/GTTTTA 1 -- int19Minor allele frequency- G:0.00NA WA CSA 18
    rs1473904381,2
    C--15208551(+) TAAAA-/GGGGGGG 1 -- int10--------
    rs104082541,2
    C--15208557(+) GGGGGA/GGAAAA 1 -- int1 trp30--------
    rs621137931,2
    C--15208568(+) AAAGAA/GCTGCC 1 -- int15Minor allele frequency- G:0.14NA EA 248
    rs621137941,2
    C--15208569(+) AAGAGA/CTGCCC 1 -- int15Minor allele frequency- C:0.14NA EA 248
    rs350581841,2
    C,F--15208572(+) AAATGC/TCCCCA 1 -- int11Minor allele frequency- T:0.44WA 118
    rs1493900601,2
    --15208642(+) CATAAA/GTACAG 1 -- int10--------
    rs3775140651,2
    C--15208653(+) GCCATC/TGGAGC 1 -- int10--------
    rs72542691,2
    C,F,H--15208661(+) GAGCAA/TAAGCA 1 -- int133Minor allele frequency- T:0.11NS EA NA WA CSA 2928
    rs1440176211,2
    --15208790(+) GGGAGC/TCACTT 1 -- int10--------
    rs1155132521,2
    C,F--15208801(+) GCATCC/TGGTTC 1 -- int11Minor allele frequency- T:0.08WA 118
    rs713347611,2
    C,F--15208802(+) CATCCG/AGTTCT 1 -- int15Minor allele frequency- A:0.08NA EA 246
    rs104168651,2
    C,H--15208833(+) GAGACC/TGACCT 1 -- int114Minor allele frequency- T:0.09NA WA CSA EA 381
    rs1145069931,2
    F--15208834(+) AGACTG/AACCTC 1 -- int11Minor allele frequency- A:0.08WA 118
    rs3715118211,2
    C--15208837(+) CTGACC/GCCCCG 1 -- int10--------
    rs104105141,2
    C,F,A,H--15208842(+) CTCCCT/CGCTCC 1 -- int125Minor allele frequency- C:0.11NS EA WA NA CSA 2351
    rs20746221,2
    C,H--15208852(+) CACCAC/GCAGAC 1 -- int114Minor allele frequency- G:0.09NA WA CSA EA 381
    rs1906691801,2
    C--15208860(+) GACCCA/GACCCC 1 -- int10--------
    rs1814216341,2
    --15208955(+) GAGCAC/TGTGAC 1 -- int10--------
    rs1859564301,2
    --15208958(+) CACGTC/GACCCT 1 -- int10--------
    rs1387091611,2
    --15208978(+) AATCAA/GAATGC 1 -- int10--------
    rs1418169191,2
    --15208986(+) TGCATC/TCTGAG 1 -- int10--------
    rs1125188321,2
    C--15208997(+) ACTTTG/TCTGGA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs1441054371,2
    C--15208999(+) TTTTC-/GTGGAG 1 -- int10--------
    rs347407031,2
    C--15209003(+) TCTGGA/CGCATT 1 -- int13Minor allele frequency- C:0.17NA WA 6
    rs1890501351,2
    --15209050(+) AGGGGA/GAAACT 1 -- int10--------
    rs104173521,2
    C,F--15209125(+) GCTAGT/GCTGAG 1 -- int17Minor allele frequency- G:0.24NA WA CSA 248
    rs15485541,2
    C,F,A,H--15209171(+) GAATAT/CACACA 1 -- int135Minor allele frequency- C:0.13NA EA NS WA CSA 4349
    rs15485551,2
    C,F,H--15209290(+) TCACTG/AACCTG 1 -- int126Minor allele frequency- A:0.14EA NA NS WA CSA EU 3630
    rs1399834301,2
    C--15209332(+) ATCTGC/TGTCGC 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs1152621821,2
    C--15209336(+) GCGTCG/ACCCTG 2 /G syn12Minor allele frequency- A:0.00WA NA 4768
    rs1811502851,2
    C--15209393(+) ACCAGA/GTGGTG 2 H syn10--------
    rs1996841191,2
    --15209426(+) ACAGCC/TTCCTC 2 E syn10--------
    rs1112622481,2
    C,F--15209485(+) TCAGAC/TCTCAC 1 -- int13Minor allele frequency- T:0.50CSA 6
    rs2001542601,2
    --15209567(+) ACACA-/TTGAGCC 1 -- int10--------
    rs2009681961,2
    --15209570(+) ACAGA-/GCCCTG 1 -- int10--------
    rs2021467101,2
    --15209572(+) GAGCC-/ATCTGGG 1 -- int10--------
    rs2003857561,2
    C--15209606(+) GTTTTA/GTTTGT 1 -- int10--------
    rs1856433351,2
    C--15209643(+) GTCCCC/TCAGGC 1 -- int10--------
    rs20746231,2
    C,F--15209756(+) GCCACA/G/TGTGTC 1 -- int19NA WA CSA 17
    rs104186601,2
    C--15209872(+) TGCTGG/AGATTA 1 -- int111Minor allele frequency- A:0.10NA WA CSA EA 372
    rs1390482341,2
    --15209907(+) CCCAAG/TGAGGT 1 -- int10--------
    rs104163891,2
    C--15209911(+) AGGAGC/GTAATA 1 -- int112Minor allele frequency- G:0.09NA WA CSA EA 374
    rs104183051,2
    C--15210042(+) CAGTGG/CTGCAA 1 -- int19Minor allele frequency- C:0.10NA CSA WA EA 369
    rs1425044481,2
    --15210044(+) GTGCTA/GCAATC 1 -- int10--------
    rs1907764491,2
    C--15210103(+) TCAGCA/GGCCCA 1 -- int10--------
    rs1505213901,2
    --15210364(+) GGGTTA/GAGCAG 1 -- int10--------
    rs3755882471,2
    C--15210405(+) TTCCAC/TTCACA 1 -- int10--------
    rs1828738631,2
    --15210441(+) GGAGTC/TTGTAA 1 -- int10--------
    rs1870366941,2
    --15210541(+) CTCAGC/TAATGC 1 -- int10--------
    rs573691601,2
    C--15210645(+) ATGCCA/GAGGCG 1 -- int17Minor allele frequency- G:0.00NA WA CSA 13
    rs1497013551,2
    --15210710(+) CCCATC/TTCTAC 1 -- int10--------
    rs1923791961,2
    --15210735(+) TTAGCC/TGGGCA 1 -- int10--------
    rs1834870921,2
    --15210736(+) TAGCCA/GGGCAT 1 -- int10--------
    rs1874578761,2
    --15210773(+) ACTCGC/GGAGGC 1 -- int10--------
    rs129819571,2
    C--15210777(+) GGGAGA/GCTGAG 1 -- int12Minor allele frequency- G:0.00NA CSA 3
    rs1923145641,2
    --15210806(+) CCTGGA/GAGGTG 1 -- int1