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NOTCH3 Gene

protein-coding   GIFtS: 69
GCID: GC19M015270

Notch 3

(Previous names: Notch (Drosophila) homolog 3, Notch homolog 3 (Drosophila))
(Previous symbol: CADASIL)
  See NOTCH3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Notch 31 2 3     Notch (Drosophila) Homolog 31
CADASIL1 2 5     Notch Homolog 3 (Drosophila)1
CASIL2 5     Neurogenic Locus Notch Homolog Protein 32
IMF22 5     Notch Homolog 32

External Ids:    HGNC: 78831   Entrez Gene: 48542   Ensembl: ENSG000000741817   OMIM: 6002765   UniProtKB: Q9UM473   

Export aliases for NOTCH3 gene to outside databases

Previous GC identifers: GC19M015649 GC19M015115 GC19M015131 GC19M014839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOTCH3 Gene:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein
notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an
intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands
have also been identified in human, but precise interactions between these ligands and the human notch homologues
remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal
dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (provided by RefSeq, Jul 2008)

GeneCards Summary for NOTCH3 Gene:
NOTCH3 (notch 3) is a protein-coding gene. Diseases associated with NOTCH3 include cadasil, and myofibromatosis, infantile 2. GO annotations related to this gene include enzyme binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
the implementation of differentiation, proliferation and apoptotic programs (By similarity)

Gene Wiki entry for NOTCH3 (Notch 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOTCH3 gene promoter:
         AP-2gamma   GATA-2   C/EBPalpha   CHOP-10   Pax-3   COMP1   STAT3   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOTCH3 promoter sequence
   Search Chromatin IP Primers for NOTCH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOTCH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2-p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.2-p13.1

NOTCH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOTCH3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M015270:  view genomic region     (about GC identifiers)

Start:
15,270,444 bp from pter      End:
15,311,792 bp from pter
Size:
41,349 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47 (See protein sequence)
Recommended Name: Neurogenic locus notch homolog protein 3 precursor  
Size: 2321 amino acids; 243631 Da
Subunit: Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by
disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators
for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN
Secondary accessions: Q9UEB3 Q9UPL3 Q9Y6L8

Explore the universe of human proteins at neXtProt for NOTCH3: NX_Q9UM47

Explore proteomics data for NOTCH3 at MOPED

Post-translational modifications: 

  • Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like
    convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible
    form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding,
    it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called
    notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to
    release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity)1
  • Phosphorylated (By similarity)1
  • Hydroxylated by HIF1AN1
  • Ubiquitination2 at Lys521, Lys1473, Lys1684
  • Glycosylation2 at Asn1179, Asn1336, Asn1438
  • Modification sites at PhosphoSitePlus

  • See NOTCH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000426.2  
    ENSEMBL proteins: 
     ENSP00000263388   ENSP00000470661   ENSP00000468879   ENSP00000473138  
    Reactome Protein details: Q9UM47

    NOTCH3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NOTCH3

     
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    antibodies-online peptides for NOTCH3

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    NOTCH3 Assay Products:

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    antibodies-online kits for NOTCH3 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 14):
     IPR010660 Notch_NOD_dom
     IPR024600 DUF3454_notch
     IPR001881 EGF-like_Ca-bd_dom
     IPR008297 Notch
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UM47

    ProtoNet protein and cluster: Q9UM47

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000800 LIN-12/notch repeat (LNR) signature
    IPB001881 EGF-like calcium-binding
    IPB002049 Laminin-type EGF-like domain
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
    Similarity: Belongs to the NOTCH family
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 34 EGF-like domains
    Similarity: Contains 3 LNR (Lin/Notch) repeats


    Find genes that share domains with NOTCH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOTC3_HUMAN, Q9UM47
    Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
    determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
    transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
    the implementation of differentiation, proliferation and apoptotic programs (By similarity)

         Genatlas biochemistry entry for NOTCH3:
    Drosophila Notch homolog 3,mediating cell-cell interactions that specify cell fate during development,undergoing a
    first proteolytic cleavage by furin (PACE1) in the Golgi during trafficking of Notch to the cell
    surface,undergoing further cleavage by gamma secretase (see PSEN1) releasing an intracellular domain (NICD) which
    translocates to the nucleus and modulates transcription of target genes,putatively involved in translocation with
    acute lymphoblastic/myeloblastic leukemia and in the decision between the endocrine and exocrine fates in the
    developing pancreas

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11101851
    GO:0019899enzyme binding IEA--
         
    Find genes that share ontologies with NOTCH3           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Notch3) (see all 20):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with NOTCH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NOTCH3: Notch3tm1Khan Notch3tm1Grid

       genOway: Develop your customized and physiologically relevant rodent model for NOTCH3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOTCH3:
    hsa-mir-1 (MIRT006550), hsa-mir-335-5p (MIRT017387), hsa-mir-484 (MIRT042194), hsa-mir-150-5p (MIRT007016), hsa-mir-206 (MIRT000665)

    Block miRNA regulation of human, mouse, rat NOTCH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOTCH3 (see all 25):
    hsa-miR-26a-2* hsa-miR-875-3p hsa-miR-3673 hsa-miR-136 hsa-miR-520d-5p hsa-miR-1263 hsa-miR-300 hsa-miR-24-1*
    SwitchGear 3'UTR luciferase reporter plasmidNOTCH3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOTCH3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for NOTCH3 

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    eBioscience FlowRNA Probe Sets ( VA1-12345 VA6-13809) for NOTCH3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOTC3_HUMAN, Q9UM47: Cell membrane; Single-pass type I membrane protein
    NOTC3_HUMAN, Q9UM47: Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is
    translocated to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    endoplasmic reticulum4
    extracellular4
    golgi apparatus4
    cytoskeleton1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with NOTCH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOTCH3 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling0.30
    Notch Signaling Pathway0.84
    Signaling by NOTCH30.00
    Delta-Notch Signaling Pathway0.33
    2Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Notch-HLH transcription pathway0.00
    Pre-NOTCH Transcription and Translation0.62
    Pre-NOTCH Processing in the Endoplasmic Reticulum0.00
    Pre-NOTCH Processing in Golgi0.00
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH0.64
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with NOTCH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOTCH3
        Notch Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOTCH3
        Notch Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for NOTCH3
        Wnt / Hedgehog / Notch
    Angiogenesis
    Neuroscience

    4 BioSystems Pathways for NOTCH3
        Notch Signaling Pathway
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    Notch signaling pathway

    5 Reactome Pathways for NOTCH3
        Pre-NOTCH Processing in Golgi
    Pre-NOTCH Transcription and Translation
    Notch-HLH transcription pathway
    Pre-NOTCH Processing in the Endoplasmic Reticulum
    Signaling by NOTCH3


    4 Kegg Pathways  (Kegg details for NOTCH3):
        Dorso-ventral axis formation
    Notch signaling pathway
    Thyroid hormone signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH3: 
              Notch Signaling Targets in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOTCH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOTCH3 (Q9UM471, 2, 3 ENSP000002633884) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253473 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253473 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253473 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0007220Notch receptor processing TAS--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with NOTCH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOTCH3 (NOTC3)

    3 Novoseek inferred chemical compound relationships for NOTCH3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 58.1 29 19043263 (2), 16256149 (2), 15714997 (1), 17331978 (1) (see all 18)
    arginine 14.1 3 15714997 (1), 11559313 (1)
    calcium 1.73 1 10024441 (1)



    Find genes that share compounds with NOTCH3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOTCH3 gene: 
    NM_000435.2  

    Unigene Cluster for NOTCH3:

    Notch 3
    Hs.8546  [show with all ESTs]
    Unigene Representative Sequence: U97669
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263388(uc002nan.3 uc002nao.1) ENST00000595514 ENST00000597756
    ENST00000601011 ENST00000600841 ENST00000595045
    miRNA
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    hsa-miR-26a-2* hsa-miR-875-3p hsa-miR-3673 hsa-miR-136 hsa-miR-520d-5p hsa-miR-1263 hsa-miR-300 hsa-miR-24-1*
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    Additional mRNA sequence: 

    AB209447.1 U97669.1 

    5 DOTS entries:

    DT.217396  DT.91963540  DT.100815125  DT.75121130  DT.91646701 

    Selected AceView cDNA sequences (see all 277):

    BI523794 BU553672 BQ919557 AI274902 T63511 BE764071 BI052410 CA433198 
    BF435534 CA446395 AW194070 AI091531 AI559175 AI473478 AI921030 AA301460 
    BU846477 BU956081 BM841037 CK904462 AI969777 BM021466 CB270591 CN483616 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOTCH3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^
    SP1:                                                                                                                    -                                       
    SP2:                                                                                      -                             -                                       
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for NOTCH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NOTCH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAATAGA
    NOTCH3 Expression
    About this image


    NOTCH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 40 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 32 entries
             Myoblasts Cervical Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Myoblasts Forelimb Ventral Muscles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    NOTCH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOTCH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8546

    UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
    Tissue specificity: Ubiquitously expressed in fetal and adult tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH3: 
              Notch Signaling Targets in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOTCH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOTCH3
    QuantiTect SYBR Green Assays in human, mouse, rat NOTCH3
    QuantiFast Probe-based Assays in human, mouse, rat NOTCH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NOTCH3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Notch31 , 5 Notch gene homolog 3 (Drosophila)5
    notch 31
    84.32(n)1
    90.99(a)1
      17 (17.37 cM)5
    181311  NM_008716.21  NP_032742.11 
     321208205 
    lizard
    (Anolis carolinensis)
    Reptilia NOTCH36
    notch 3
    63(a)
    1 ↔ 1
    2(103176116-103239023)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420334872   -- 76.95(n)    142033487 
    zebrafish
    (Danio rerio)
    Actinopterygii AF152001.12   -- 75.66(n)   58066  AF152001.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SP10703 Notch binding 38(a)
    (best of 2)
      27D2   --


    ENSEMBL Gene Tree for NOTCH3 (if available)
    TreeFam Gene Tree for NOTCH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOTCH3 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  DLL42  JAG22  CRB22  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    Selected SIMAP similar genes for NOTCH3 using alignment to 5 protein entries:     NOTC3_HUMAN (see all proteins) (see all similar genes):
    F9 p22    factor IX F9    CRB1    F9    SVEP1    SLIT3
    NOTCH2    PPP1R12A    SLIT2    FBLN7    NOTCH1    PROS1
    VCAN    DLL3    ACAN    GABPB1    SNED1    ANKRD44

    Find genes that share paralogs with NOTCH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOTCH3 (see all 1322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011180341,2,,4
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 --15229476(+) GTTGCA/GATCAC 2 R C mis10--------
    rs289336981,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115231165(-) TCACCC/TGTATC 2 R C mis1 ese30--------
    rs289336971,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115234256(-) CCTTCC/TGCTGC 2 R C mis1 ese30--------
    rs289336961,2,,4
    CCerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4 pathogenic115234295(-) CCTGCC/TGCCAT 2 R C mis1 ese30--------
    VAR_0443044
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443042 C Y mis40--------
    VAR_0442344
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442342 C S mis40--------
    VAR_0128904
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128902 C Y mis40--------
    VAR_0128964
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0128962 R C mis40--------
    VAR_0442864
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0442862 C R mis40--------
    VAR_0443134
    Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)4--see VAR_0443132 C R mis40--------

    HapMap Linkage Disequilibrium report for NOTCH3 (15270444 - 15311792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NOTCH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718225CNV Deletion23290073
    nsv911131CNV Loss21882294
    esv997404CNV Loss20482838
    esv34154CNV Loss18971310
    nsv521424CNV Loss19592680
    nsv911132CNV Loss21882294

    Human Gene Mutation Database (HGMD): NOTCH3
    Locus Specific Mutation Databases (LSDB): NOTCH3

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing NOTCH3:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing NOTCH3
    DNA2.0 Custom Variant and Variant Library Synthesis for NOTCH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600276   
    OMIM disorders: 125310  615293  
    UniProtKB/Swiss-Prot: NOTC3_HUMAN, Q9UM47
  • Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)
    [MIM:125310]: A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy,
    dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Myofibromatosis, infantile 2 (IMF2) [MIM:615293]: A rare mesenchymal disorder characterized by the
    development of benign tumors in the skin, striated muscles, bones, and, more rarely, visceral organs.
    Subcutaneous or soft tissue nodules commonly involve the skin of the head, neck, and trunk. Skeletal and muscular
    lesions occur in about half of the patients. Lesions may be solitary or multicentric, and they may be present at
    birth or become apparent in early infancy or occasionally in adult life. Visceral lesions are associated with
    high morbidity and mortality. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 14 diseases for NOTCH3:    
    About MalaCards
    cadasil    myofibromatosis, infantile 2    balo's concentric sclerosis    myofibromatosis, infantile, 1
    cerebrovascular disease    pseudobulbar palsy    hemiplegic migraine    migraine with aura
    infantile myofibromatosis    familial hemiplegic migraine    varicose veins    ossifying fibroma
    vascular dementia    migraine

    5 diseases from the University of Copenhagen DISEASES database for NOTCH3:
    Cadasil     Migraine     Vascular dementia     Cerebrovascular accident
    Pseudobulbar palsy

    Find genes that share disorders with NOTCH3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NOTCH3 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadasil 99.3 380 15857853 (5), 10766655 (5), 11391502 (5), 16580020 (5) (see all 99)
    infarct 87.7 115 18572291 (2), 12417361 (2), 16949066 (2), 16580020 (2) (see all 99)
    migraine 83 26 16492242 (6), 16426270 (3), 19018300 (2), 15313840 (1) (see all 12)
    dementia vascular 82 11 11757773 (1), 11706120 (1), 11102981 (1), 15857853 (1) (see all 10)
    dementia 76.1 27 11391502 (3), 11591842 (1), 10712431 (1), 10716263 (1) (see all 24)
    subcortical infarction 74.7 3 16580020 (1), 19242647 (1)
    infarction lacunar 74 2 17239802 (1), 12511775 (1)
    stroke 73.4 33 7783868 (2), 11591842 (1), 11757773 (1), 10712431 (1) (see all 31)
    cerebrovascular disease 66.2 13 11861701 (2), 11578869 (1), 19139365 (1), 12480758 (1) (see all 10)
    t-all 60.4 10 11891328 (2), 12524208 (1), 18032925 (1), 16838279 (1) (see all 7)

    GeneTests: NOTCH3
    GeneReviews: NOTCH3
    Genetic Association Database (GAD): NOTCH3
    Human Genome Epidemiology (HuGE) Navigator: NOTCH3 (67 documents)

    Export disorders for NOTCH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOTCH3 gene, integrated from 10 sources (see all 366) (see top 10):
    (articles sorted by number of sources associating them with NOTCH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies. (PubMed id 16009764)1, 2, 4, 9 Peters N.... Dichgans M. (Arch. Neurol. 2005)
    2. CADASIL: extended polymorphisms and mutational analysis of the NOTCH3 gene. (PubMed id 19006080)1, 4, 9 Ungaro C....Quattrone A. (J. Neurosci. Res. 2009)
    3. Investigating the association between Notch3 polymorphism and migraine. (PubMed id 16492242)1, 4, 9 Borroni B....Padovani A. (Headache 2006)
    4. Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis. (PubMed id 12810003)1, 2, 9 Santa Y....Tabira T. (J. Neurol. Sci. 2003)
    5. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. (PubMed id 9388399)1, 2, 9 Joutel A.... Tournier-Lasserve E. (Lancet 1997)
    6. Population-specific spectrum of NOTCH3 mutations, MRI features and founder effect of CADASIL in Chinese. (PubMed id 19242647)1, 4, 9 Lee Y.C....Soong B.W. (J. Neurol. 2009)
    7. Notch3 gene polymorphism and ischaemic cerebrovascular disease. (PubMed id 11861701)1, 4, 9 Ito D....Fukuuchi Y. (J. Neurol. Neurosurg. Psychiatr. 2002)
    8. Investigation of the NOTCH3 and TNFSF7 genes on C19p13 as candidates for migraine. (PubMed id 19018300)1, 4, 9 Smith R.A....Griffiths L. (Open Neurol J 2008)
    9. Genetic variants of the NOTCH3 gene in migraine--a mutation analysis and association study. (PubMed id 16426270)1, 4, 9 Schwaag S....KuhlenbAoumer G. (Cephalalgia 2006)
    10. A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings. (PubMed id 11559313)1, 2, 9 Oliveri R.L.... Quattrone A. (Arch. Neurol. 2001)
    11. Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis. (PubMed id 12511775)1, 4, 9 Dong Y....Markus H.S. ( a journal of cerebral circulation 2003)
    12. [Monitoring cognitive characteristics in a population with hereditary cerebrovascular disease (CADASIL) in Colombia]. (PubMed id 18075987)1, 4, 9 Henao-Arboleda E....Lopera F. (Rev Neurol 2007)
    13. MRI correlates of cognitive decline in CADASIL: a 7-year follow-up study. (PubMed id 19139365)1, 4, 9 Liem M.K....van der Grond J. (Neurology 2009)
    14. Lack of association between NOTCH3 gene polymorphism and cerebrovascular disease in Japanese patients. (PubMed id 12480758)1, 4, 9 Mizuno T....Nakajima K. (Ann. N. Y. Acad. Sci. 2002)
    15. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. (PubMed id 8878478)1, 2, 9 Joutel A.... Tournier-Lasserve E. (Nature 1996)
    16. Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals. (PubMed id 20167921)1, 4 Adib-Samii P....Markus H.S. ( a journal of cerebral circulation 2010)
    17. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    18. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    19. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    20. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    21. [Periodontal disease as an early clinical sign of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)]. (PubMed id 19859875)1, 4 Luna-Maldonado E....Lopera F. (Rev Neurol 2009)
    22. Conserved signal peptide of Notch3 inhibits interaction with proteasome. (PubMed id 17292860)1, 2 Zhang Y.... Wang M.M. (Biochem. Biophys. Res. Commun. 2007)
    23. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. (PubMed id 17573339)1, 2 Coleman M.L.... Schofield C.J. (J. Biol. Chem. 2007)
    24. Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. (PubMed id 16899352)1, 4 Passos Gregorio S....Dias-Neto E. (Schizophr. Res. 2006)
    25. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    26. Detection of the founder effect in Finnish CADASIL families. (PubMed id 15378071)1, 2 Mykkaenen K....Peoyhoenen M. (Eur. J. Hum. Genet. 2004)
    27. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PubMed id 12370315)1, 2 Wu L.... Griffin J.D. (Mol. Cell. Biol. 2002)
    28. C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke. (PubMed id 12136071)1, 2 Arboleda-Velasquez J.F.... Kosik K.S. (Neurology 2002)
    29. Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL. (PubMed id 10802807)1, 2 Joutel A.... Tournier-Lasserve E. (Neurology 2000)
    30. Description of a simple test for CADASIL disease and determination of mutation frequencies in sporadic ischaemic stroke and dementia patients. (PubMed id 11032621)1, 4 Wang T....Sharma P. (J. Neurol. Neurosurg. Psychiatr. 2000)
    31. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. (PubMed id 11101851)1, 2 Wu L....Griffin J.D. (Nat. Genet. 2000)
    32. Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (Am. J. Pathol. 1999)
    33. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. (PubMed id 7835890)1, 3 Sugaya K.... Ikemura T. (Genomics 1994)
    34. An overview of Notch3 function in vascular smooth muscle cells. (PubMed id 17854869)1, 9 Wang T....Trump D. (Prog. Biophys. Mol. Biol. 2008)
    35. Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation. (PubMed id 19825845)1, 9 Takahashi K....Watanabe A. (Hum. Mol. Genet. 2010)
    36. Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain. (PubMed id 18273901)2, 9 Fouillade C.... Joutel A. (Hum. Mutat. 2008)
    37. Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway. (PubMed id 14714274)1, 9 Joutel A....Tournier-Lasserve E. (Am. J. Hum. Genet. 2004)
    38. Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients. (PubMed id 19174371)1, 9 Tikka S....Kalimo H. (Brain 2009)
    39. Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain. (PubMed id 19293235)1, 9 Monet-LeprA-tre M....Joutel A. (Brain 2009)
    40. The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. (PubMed id 17331978)1, 9 Monet M....Joutel A. (Hum. Mol. Genet. 2007)
    41. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. (PubMed id 10712431)1, 9 Joutel A....Tournier-Lasserve E. (J. Clin. Invest. 2000)
    42. Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia. (PubMed id 19966856)1, 9 Checquolo S....Screpanti I. (Oncogene 2010)
    43. Lysosome-dependent degradation of Notch3. (PubMed id 19735738)1, 9 Jia L....Wang M.M. (amp 2009)
    44. Notch3: from subtle structural differences to functional diversity. (PubMed id 18758477)1, 9 Bellavia D....Screpanti I. (Oncogene 2008)
    45. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. (PubMed id 11891328)1, 9 Bellavia D....Screpanti I. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    46. Notch3 signaling promotes the development of pulmonary arterial hypertension. (PubMed id 19855400)1, 9 Li X....Thistlethwaite P.A. (Nat. Med. 2009)
    47. A new de novo Notch3 mutation causing CADASIL. (PubMed id 16796587)1, 9 Coto E....Alvarez V. (Eur. J. Neurol. 2006)
    48. Functional analysis of a recurrent missense mutation in Notch3 in CADASIL. (PubMed id 16107360)1, 9 Haritunians T....Schanen C. (J. Neurol. Neurosurg. Psychiatr. 2005)
    49. Report of two Chinese families and a review of Mainland Chinese CADASIL patients. (PubMed id 19167727)1, 9 Yin X.Z....Zhao G.H. (J. Neurol. Sci. 2009)
    50. Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit? (PubMed id 18572291)1, 9 Guerrot D....Godin M. (Am. J. Kidney Dis. 2008)
    51. A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an octogenarian paucisymptomatic patient. (PubMed id 18022198)1, 9 Pescini F....Pantoni L. (J. Neurol. Sci. 2008)
    52. [A new Spanish family with CADASIL associated with 346C&gt;T mutation of NOTCH3 gene]. (PubMed id 17853970)1, 9 Avila A....GA^mez M.I. (Neurologia 2007)
    53. Arg332Cys mutation of NOTCH3 gene in the first known Taiwanese family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 15694192)1, 9 Tang S.C....Yip P.K. (J. Neurol. Sci. 2005)
    54. Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis. (PubMed id 11755616)2, 9 Joutel A.... Tournier-Lasserve E. (Lancet 2001)
    55. De novo mutation in the Notch3 gene causing CADASIL. (PubMed id 10716263)1, 9 Joutel A....Bousser M.G. (Ann. Neurol. 2000)
    56. Evaluation of DHPLC analysis in mutational scanning of Notch3, a gene with a high G-C content. (PubMed id 11102981)2, 9 Escary J.-L.... Joutel A. (Hum. Mutat. 2000)
    57. A novel heterozygous mutation in the NOTCH3 gene causing CADASIL. (PubMed id 18941948)1, 9 Andreadou E....Sfagos C. (Swiss Med Wkly 2008)
    58. Two Japanese CADASIL families exhibiting Notch3 mutation R75P not involving cysteine residue. (PubMed id 19043263)1, 9 Mizuno T....Nakagawa M. (Intern. Med. 2008)
    59. Neuromuscular implications in CADASIL. (PubMed id 17878719)1, 9 Finsterer J. (Cerebrovasc. Dis. 2007)
    60. Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 17390743)1, 9 Kusaba T....Matsubara H. (Clin. Nephrol. 2007)
    61. Mitochondrial DNA sequence variation and mutation rate in patients with CADASIL. (PubMed id 16807713)1, 9 Annunen-Rasila J.... Majamaa K. (Neurogenetics 2006)
    62. Characteristics of CADASIL in Korea: a novel cysteine-sparing Notch3 mutation. (PubMed id 16717210)1, 9 Kim Y....Kim J.S. (Neurology 2006)
    63. Acute unilateral visual loss as the first symptom of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 15096408)1, 9 Rufa A....Federico A. (Arch. Neurol. 2004)
    64. Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients. Dutch CADASIL Research Group. (PubMed id 10371548)2, 9 Lesnik Oberstein S.A.J.... Haan J. (Neurology 1999)
    65. Different clinical phenotypes in monozygotic CADASIL twins with a novel NOTCH3 mutation. (PubMed id 19372454)1, 9 MykkAonen K....Viitanen M. ( a journal of cerebral circulation 2009)
    66. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy and right-to-left shunt: lack of evidence for an association in a prevalence study. (PubMed id 18948701)1, 9 Mazzucco S....Rizzuto N. (Eur. Neurol. 2009)
    67. Sporadic vascular dementia as clinical presentation of a new missense mutation within exon 7 of NOTCH3 gene. (PubMed id 18499132)1, 9 Pradotto L....Mauro A. (J. Neurol. Sci. 2008)
    68. Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients. (PubMed id 15364702)2, 9 Opherk C.... Dichgans M. (Brain 2004)
    69. A novel mutation (C67Y)in the NOTCH3 gene in a Korean CADASIL patient. (PubMed id 12589106)2, 9 Moon S.-Y.... Na D.L. (J. Korean Med. Sci. 2003)
    70. CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. (PubMed id 12146805)2, 9 Kalimo H.... Kalaria R.N. (Brain Pathol. 2002)
    71. No association between multiple sclerosis and the Notch3 gene responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 11413271)4, 9 Broadley S.A....Compston D.A. (J. Neurol. Neurosurg. Psychiatr. 2001)
    72. Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients. (PubMed id 20038773)1, 9 Pantoni L....Inzitari D. (Neurology 2010)
    73. NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells. (PubMed id 19835636)1, 9 Nagel S....Macleod R.A. (BMC Cancer 2009)
    74. High recurrence of the R1006C NOTCH3 mutation in central Italian patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 19576955)1, 9 Cappelli A....Pianese L. (Neurosci. Lett. 2009)
    75. Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells. (PubMed id 18483410)1, 9 Jin S....Lendahl U. (Circ. Res. 2008)
    76. Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis. (PubMed id 18069660)1, 9 Bhanot U....MAPller P. (J. Pathol. 2008)
    77. A novel Notch3 gene mutation not involving a cysteine residue in an Italian family with CADASIL. (PubMed id 15304596)1, 9 Mazzei R....Quattrone A. (Neurology 2004)
    78. Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 12861102)4, 9 Lesnik Oberstein S.A....Haan J. (Medicine (Baltimore) 2003)
    79. NOTCH3 mutation involving three cysteine residues in a family with typical CADASIL. (PubMed id 11706120)1, 9 Dichgans M....Gasser T. (Neurology 2001)
    80. Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains. (PubMed id 10854111)2, 9 Dichgans M....Gasser T. (Eur. J. Hum. Genet. 2000)
    81. Quantitative MRI in CADASIL: correlation with disability and cognitive performance. (PubMed id 10227618)2, 9 Dichgans M....Yousry T.A. (Neurology 1999)
    82. Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. (PubMed id 23637910)1 Kuang S.Q....Garcia-Manero G. (PLoS ONE 2013)
    83. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. (PubMed id 23747483)1 Tiyanont K....Blacklow S.C. (J. Mol. Biol. 2013)
    84. First deep intronic mutation in the NOTCH3 gene in a family with late-onset CADASIL. (PubMed id 23587639)1 Bianchi S....Federico A. (Neurobiol. Aging 2013)
    85. Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer. (PubMed id 23729168)1 Danza G....Tarantini F. (Int. J. Cancer 2013)
    86. Unusual clinical presentations in subjects carrying novel NOTCH3 gene mutations. (PubMed id 23465844)1 Spinicci G....Carboni N. (J Stroke Cerebrovasc Dis 2013)
    87. Human equilibrative nucleoside transporter 1 and Notch3 can predict gemcitabine effects in patients with unresectable pancreatic cancer. (PubMed id 23492684)1 Eto K....Sakamoto N. (Br. J. Cancer 2013)
    88. Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells. (PubMed id 23975424)1 Lu C....Zhou G.P. (Oncogene 2013)
    89. Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL. (PubMed id 23649698)1 Monet-LeprA-tre M....Joutel A. (Brain 2013)
    90. The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. (PubMed id 23468978)1 Zhou L....Dou K. (PLoS ONE 2013)
    91. Notch3 functions as a tumor suppressor by controlling cellular senescence. (PubMed id 23610446)1 Cui H....Zhang H. (Cancer Res. 2013)
    92. Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer. (PubMed id 23645556)1 Ye Y.Z....Zhang Y.B. (Med. Oncol. 2013)
    93. Parkinsonism is a late, not rare, feature of CADASIL: a study on Italian patients carrying the R1006C mutation. (PubMed id 23412372)1 Ragno M....De Michele G. ( a journal of cerebral circulation 2013)
    94. Novel MIR143-NOTCH fusions in benign and malignant glomus tumors. (PubMed id 23999936)1 Mosquera J.M....Antonescu C.R. (amp 2013)
    95. Aberrant expression of Notch3 predicts poor survival for hepatocellular carcinomas. (PubMed id 23836039)1 Hu L....Wei G. (Biosci Trends 2013)
    96. A NOTCH3 transcriptional module induces cell motility in neuroblastoma. (PubMed id 23649002)1 van Nes J....Versteeg R. (Clin. Cancer Res. 2013)
    97. A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. (PubMed id 23602593)1 Soong B.W....Lee Y.C. (J Chin Med Assoc 2013)
    98. Experimental studies of mitochondrial function in CADASIL vascular smooth muscle cells. (PubMed id 23036509)1 Viitanen M....Behbahani H. (Exp. Cell Res. 2013)
    99. Brain microvascular accumulation and distribution of the NOTCH3 ectodomain and granular osmiophilic material in CADASIL. (PubMed id 23584202)1 Yamamoto Y....Kalaria R.N. (J. Neuropathol. Exp. Neurol. 2013)
    100. Screening for NOTCH3 gene mutations among 151 consecutive Korean patients with acute ischemic stroke. (PubMed id 22133740)1 Choi J.C....Kang J.H. (J Stroke Cerebrovasc Dis 2013)
    101. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. (PubMed id 23444212)1 Hassan K.A....Wicha M.S. (Clin. Cancer Res. 2013)
    102. Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis. (PubMed id 23731542)2 Martignetti J.A....Hakonarson H. (Am. J. Hum. Genet. 2013)
    103. Genetically proven cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a 3-year-old. (PubMed id 23460375)1 Benabu Y....Boucher R.M. (Pediatr Radiol 2013)
    104. A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. (PubMed id 23845442)1 Zheng Y....Sweet-Cordero E.A. (Cancer Cell 2013)
    105. Diversity of stroke presentation in CADASIL: study from patients harboring the predominant NOTCH3 mutation R544C. (PubMed id 21852154)1 Choi J.C....Kang J.H. (J Stroke Cerebrovasc Dis 2013)
    106. Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer. (PubMed id 23010708)1 Rahman M.T....Miyazaki K. (Am. J. Clin. Pathol. 2012)
    107. Overexpression of the Notch3 receptor in non-functioning pituitary tumours. (PubMed id 22153798)1 Miao Z....Lu X. (J Clin Neurosci 2012)
    108. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. (PubMed id 23019585)1 McAuliffe S.M....Dinulescu D.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    109. Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. (PubMed id 22806125)1 Djudjaj S....Mertens P.R. (J. Pathol. 2012)
    110. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)
    111. Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. (PubMed id 23028706)1 Meng H....Wang M.M. (PLoS ONE 2012)
    112. Notch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma. (PubMed id 23226563)1 Mann C.D....Manson M.M. (PLoS ONE 2012)
    113. Multi-organ investigation in 16 CADASIL families from central Italy sharing the same R1006C mutation. (PubMed id 22079340)1 Ragno M....Trojano L. (Neurosci. Lett. 2012)
    114. Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm. (PubMed id 22310065)1 Biros E....Golledge J. (Atherosclerosis 2012)
    115. Acetylation controls Notch3 stability and function in T-cell leukemia. (PubMed id 22120716)1 Palermo R....Screpanti I. (Oncogene 2012)
    116. CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells. (PubMed id 22948298)1 Tikka S....Baumann M. (J. Cereb. Blood Flow Metab. 2012)
    117. The role of endothelial cell-bound Jagged1 in Notch3-induced human coronary artery smooth muscle cell differentiation. (PubMed id 22204979)1 Xia Y....Mequanint K. (Biomaterials 2012)
    118. Notch3 regulates the activation of hepatic stellate cells. (PubMed id 22493555)1 Chen Y.X....Zhang S.L. (World J. Gastroenterol. 2012)
    119. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration in association with CADASIL. (PubMed id 22367839)1 Kim H.J....Kim S.H. (Neurologist 2012)
    120. Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo. (PubMed id 22117196)1 Raimondi L....Rota R. (Cell Death Differ. 2012)
    121. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. (PubMed id 21743488)1 Pradeep C.R....Yarden Y. (Oncogene 2012)
    122. Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease. (PubMed id 22153900)1 Guerreiro R.J....Singleton A. (Neurobiol. Aging 2012)
    123. Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice. (PubMed id 22292737)1 Gu X....Zhao L.R. (Ultrastruct Pathol 2012)
    124. Human peripheral blood lymphocytes and fibroblasts as Notch3 expression models. (PubMed id 21702048)1 Di Maio G....Federico A. (J. Cell. Physiol. 2012)
    125. Transendocytosis is impaired in CADASIL-mutant NOTCH3. (PubMed id 22079830)1 Watanabe-Hosomi A....Mizuno T. (Exp. Neurol. 2012)
    126. The minimum prevalence of CADASIL in northeast England. (PubMed id 22422895)1 Narayan S.K....Chinnery P.F. (Neurology 2012)
    127. CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? (PubMed id 22218279)1 Chitnis T. and Hollmann T.J. (Neurology 2012)
    128. Silencing of Notch3 Using shRNA driven by survivin promoter inhibits growth and promotes apoptosis of human T-cell acute lymphoblastic leukemia cells. (PubMed id 21940234)1 Xiang J....Zhang H. (amp 2012)
    129. Mutational and haplotype map of NOTCH3 in a cohort of Italian patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 22664156)1 Testi S....Fabrizi G.M. (J. Neurol. Sci. 2012)
    130. Identification of a known mutation in Notch 3 in familiar CADASIL in China. (PubMed id 22623959)1 Tan Z.X....Liu S.L. (PLoS ONE 2012)
    131. CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma. (PubMed id 22705236)1 Giovannini C....Bolondi L. (Am. J. Pathol. 2012)
    132. Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary. (PubMed id 22526456)1 Krikelis D....Pavlidis N. (amp 2012)
    133. Defining NOTCH3 target genes in ovarian cancer. (PubMed id 22396495)1 Chen X....Wang T.L. (Cancer Res. 2012)
    134. The genetics of white matter lesions. (PubMed id 21951372)1 Assareh A....Sachdev P.S. (amp 2011)
    135. Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3. (PubMed id 21169401)1 Zhu J.H....Flavahan N.A. (Am. J. Physiol. Heart Circ. Physiol. 2011)
    136. NOTCH3 gene mutations in subjects clinically suspected of CADASIL. (PubMed id 21616505)1 Mosca L....Penco S. (J. Neurol. Sci. 2011)
    137. Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis. (PubMed id 21628316)1 Duering M....Opherk C. (Hum. Mol. Genet. 2011)
    138. Activation of Notch signaling in human tongue carcinoma. (PubMed id 20819128)1 Zhang T.H....Liao G.Q. (amp 2011)
    139. CADASIL with cord involvement associated with a novel and atypical NOTCH3 mutation. (PubMed id 21217157)1 Bentley P....Sharma P. (J. Neurol. Neurosurg. Psychiatr. 2011)
    140. Role of STRAP in regulating GSK3I^ function and Notch3 stabilization. (PubMed id 21502811)1 Kashikar N.D....Datta P.K. (Cell Cycle 2011)
    141. Notch3 activation promotes invasive glioma formation in a tissue site-specific manner. (PubMed id 21245095)1 Pierfelice T.J....Eberhart C.G. (Cancer Res. 2011)
    142. Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells. (PubMed id 21602525)1 Nwabo Kamdje A.H....Krampera M. (Blood 2011)
    143. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy affecting an African American man: identification of a novel 15-base pair NOTCH3 duplication. (PubMed id 22159056)1 Lee S.J....Wang M.M. (Arch. Neurol. 2011)
    144. Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling. (PubMed id 21705670)1 Pajaniappan M....Lilly B. (Am. J. Physiol. Heart Circ. Physiol. 2011)
    145. Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150. (PubMed id 21551231)1 Ghisi M....Zanovello P. (Blood 2011)
    146. NOTCH3 mutations and clinical features in 33 mainland Chinese families with CADASIL. (PubMed id 20935329)1 Wang Z....Wu S. (J. Neurol. Neurosurg. Psychiatr. 2011)
    147. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    148. A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors. (PubMed id 21890822)1 Ohashi S....Nakagawa H. (Cancer Res. 2011)
    149. Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 21940951)1 Wallays G....Dewerchin M. (Arterioscler. Thromb. Vasc. Biol. 2011)
    150. Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease. (PubMed id 22006983)1 Schmidt H....Schmidt R. (Brain 2011)
    151. Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta. (PubMed id 21726900)1 Herr F....Zygmunt M. (Placenta 2011)
    152. Notch signaling modulates MUC16 biosynthesis in an in vitro model of human corneal and conjunctival epithelial cell differentiation. (PubMed id 21508102)1 Xiong L....ArgA1eso P. (amp 2011)
    153. Association of a Notch 3 gene polymorphism with migraine susceptibility. (PubMed id 20813781)1 Menon S....Griffiths L.R. (Cephalalgia 2011)
    154. Association analysis of Notch pathway signalling genes in diabetic nephropathy. (PubMed id 21103979)1 Kavanagh D....Savage D.A. (Diabetologia 2011)
    155. HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro. (PubMed id 21920521)1 Liu Y....Alexander M.Y. (Atherosclerosis 2011)
    156. p.Arg332Cys mutation of NOTCH3 gene in two unrelated Japanese families with CADASIL. (PubMed id 22082899)1 Sano Y....Kanda T. (Intern. Med. 2011)
    157. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    158. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    159. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    160. Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study. (PubMed id 21471519)1 Aparicio L.M....BolA^s M.V. (amp 2011)
    161. First report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family. (PubMed id 21409506)1 Valenti R....Pantoni L. (J. Neurol. 2011)
    162. Evidence of the cross talk between Wnt and Notch signaling pathways in non-small-cell lung cancer (NSCLC): Notch3-siRNA weakens the effect of LiCl on the cell cycle of NSCLC cell lines. (PubMed id 20614134)1 Li C....Xue X. (J. Cancer Res. Clin. Oncol. 2011)
    163. Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP. (PubMed id 21673954)1 Iwai A....Miyazaki T. (PLoS ONE 2011)
    164. Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim. (PubMed id 19881544)1 Konishi J....Dang T.P. (Oncogene 2010)
    165. Notch3 is critical for proper angiogenesis and mural cell investment. (PubMed id 20689064)1 Liu H....Lilly B. (Circ. Res. 2010)
    166. Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma. (PubMed id 20624166)1 Jung S.G....An H.J. (Cancer Sci. 2010)
    167. Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. (PubMed id 20472562)1 Meng H....Wang M.M. (J. Biol. Chem. 2010)
    168. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. (PubMed id 21124806)1 Del Bianco C....Blacklow S.C. (PLoS ONE 2010)
    169. Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws. (PubMed id 20040020)1 Zhang T.H....Zheng G.S. (amp 2010)
    170. High frequency of exon 10 mutations in the NOTCH3 gene in Italian CADASIL families: phenotypic peculiarities. (PubMed id 20169447)1 Bianchi S....Federico A. (J. Neurol. 2010)
    171. Genetically confirmed CADASIL in a pediatric patient. (PubMed id 21078731)1 Cleves C....Hussain M.S. (Pediatrics 2010)
    172. Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. (PubMed id 19603167)1 Ma D....Hou M. (Ann. Hematol. 2010)
    173. A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. (PubMed id 20069356)1 Wu J.K....Kitajewski J. (Angiogenesis 2010)
    174. Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. (PubMed id 20671266)1 Park J.T....Wang T.L. (Am. J. Pathol. 2010)
    175. Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. (PubMed id 20554499)1 Siar C.H....Kawakami T. (Eur. J. Med. Res. 2010)
    176. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. (PubMed id 20801121)1 Ohashi S....Nakagawa H. (Gastroenterology 2010)
    177. Notch3 in human breast cancer cell lines regulates osteoblast-cancer cell interactions and osteolytic bone metastasis. (PubMed id 20651241)1 Zhang Z....Hauschka P.V. (Am. J. Pathol. 2010)
    178. Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes. (PubMed id 20359736)1 Yeasmin S....Miyazaki K. (Gynecol. Oncol. 2010)
    179. Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway. (PubMed id 19816816)1 Yao J. and Qian C. (Med. Oncol. 2010)
    180. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. (PubMed id 21118965)1 Sullivan J.P....Minna J.D. (Cancer Res. 2010)
    181. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. (PubMed id 19503073)1 Schmidt M.H....Dikic I. (Nat. Cell Biol. 2009)
    182. Conventional MRI and NOTCH3 gene screening in sporadic CADASIL. (PubMed id 19056668)1 Liguori M....Quattrone A. (Neurology 2009)
    183. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    184. Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. (PubMed id 19208840)1 Indraccolo S....Amadori A. (Cancer Res. 2009)
    185. A case report about CADASlL: mutation in the NOTCH 3 receptor. (PubMed id 20329594)1 Delibas S....Comoglu S.S. (Acta Neurol Taiwan 2009)
    186. Expression and clinical significance of Notch receptors in human renal cell carcinoma. (PubMed id 19404845)1 Sun S....Fan D. (Pathology 2009)
    187. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. (PubMed id 19373490)1 Liu J....Hui R. (Hum. Genet. 2009)
    188. NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. (PubMed id 19150886)1 Liu H....Lilly B. (Circ. Res. 2009)
    189. CADASIL mutations enhance spontaneous multimerization of NOTCH3. (PubMed id 19417009)1 Opherk C....Dichgans M. (Hum. Mol. Genet. 2009)
    190. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. (PubMed id 18299578)2 Zheng X.... Poellinger L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    191. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. (PubMed id 18632624)1 Choi J.H....Wang T.L. (Cancer Res. 2008)
    192. Deregulated expression of Notch receptors in human hepatocellular carcinoma. (PubMed id 17920003)1 Gao J....Fan D. (Dig Liver Dis 2008)
    193. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Arabs. (PubMed id 18626519)1 Bohlega S.A. and Abu-Amero K.K. (Saudi Med J 2008)
    194. Cysteine-sparing notch3 mutations: cadasil or cadasil variants? (PubMed id 18765654)1 Scheid R....Froster U.G. (Neurology 2008)
    195. Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. (PubMed id 18974129)1 Park J.T....Wang T.L. (Cancer Res. 2008)
    196. NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. (PubMed id 18339869)1 Yamaguchi N....Watanabe S. (Cancer Res. 2008)
    197. CADASIL in Arabs: clinical and genetic findings. (PubMed id 17996090)1 Bohlega S....Abu-Amero K.K. (BMC Med. Genet. 2007)
    198. Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias. (PubMed id 18184405)1 Lee S.H....Lee S.H. (APMIS 2007)
    199. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. (PubMed id 17804716)1 Konishi J....Dang T.P. (Cancer Res. 2007)
    200. Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth muscle cell axis in response to pulp injury. (PubMed id 17939118)1 Lovschall H....Kjeldsen A.L. (Int. J. Dev. Biol. 2007)
    201. A study on Notch signaling in human breast cancer. (PubMed id 17822320)1 Zang S....Guo D. (Neoplasma 2007)
    202. Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway. (PubMed id 17822871)1 Wang T....Trump D. (Cell. Signal. 2007)
    203. p14ARF interacts with N-Myc and inhibits its transcriptional activity. (PubMed id 17289033)1 Amente S....Majello B. (FEBS Lett. 2007)
    204. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    205. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (PubMed id 18060036)1 Sansone P....BonafA" M. (J. Clin. Invest. 2007)
    206. Clinical presentation of CADASIL in an Italian patient with a rare Gly528Cys exon 10 NOTCH3 gene mutation. (PubMed id 17690848)1 Ragno M....Trojano L. (Neurol. Sci. 2007)
    207. p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. (PubMed id 17158237)1 Sansone P....BonafAc M. (Stem Cells 2007)
    208. Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. (PubMed id 17696940)1 Gramantieri L....Bolondi L. (Liver Int. 2007)
    209. Impaired expression of Notch signaling genes in aged human skeletal muscle. (PubMed id 17301032)1 Carey K.A....Cameron-Smith D. (J. Gerontol. A Biol. Sci. Med. Sci. 2007)
    210. Two novel Italian CADASIL families from Central Italy with mutation CGC-TGC at codon 1006 in the exon 19 Notch3 gene. (PubMed id 16998728)1 Ragno M....Trojano L. (Neurol. Sci. 2006)
    211. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 16833034)1 Guidetti D....Dotti M.T. (Clin. Exp. Hypertens. 2006)
    212. Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. (PubMed id 15987768)1 Morrow D....Cahill P.A. (Am. J. Physiol., Cell Physiol. 2005)
    213. Gene symbol: NOTCH3. Disease: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 15818833)2 Soong B.W.... Lu Y.-C. (Hum. Genet. 2005)
    214. The influence of genetic and cardiovascular risk factors on the CADASIL phenotype. (PubMed id 15229130)2 Singhal S.... Markus H.S. (Brain 2004)
    215. An Italian case of CADASIL with mutation CGC-TCG in codon 1006, exon 19 Notch3 gene. (PubMed id 14767686)1 Guidetti D....Brini M. (Neurol. Sci. 2004)
    216. Gene symbol: NOTCH3. Disease: CADASIL. (PubMed id 15300988)2 Rojas-Marcos I.... Garcia-Lozano J.R. (Hum. Genet. 2004)
    217. Mutation of the Notch 3 gene in a Thai cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy family. (PubMed id 12678157)1 Suwanwela N....Suwanwela N. (J Med Assoc Thai 2003)
    218. [Molecular basis and physiopathogenic mechanisms of CADASIL: a model of small vessel diseases of the brain]. (PubMed id 12134625)1 Joutel A. and Tournier-Lasserve E. (J. Soc. Biol. 2002)
    219. Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. (PubMed id 11978185)1 ThAclu J....Favier B. (BMC Dermatol. 2002)
    220. Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. (PubMed id 12210282)1 Ahearn E.P....Krishnan K.R. (Am. J. Med. Genet. 2002)
    221. Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL. (PubMed id 11810186)2 Feuerhake F.... Dichgans M. (Acta Neuropathol. 2002)
    222. A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. (PubMed id 12482954)1 KarlstrAPm H....Lundkvist J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    223. The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. (PubMed id 11404076)1 Beatus P....Lendahl U. (Mech. Dev. 2001)
    224. Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. (PubMed id 11518718)1 Saxena M.T....Kopan R. (J. Biol. Chem. 2001)
    225. [Report of a patient with CADASIL having a novel missense mutation of the Notch 3 gene--association with alopecia and lumbar herniated disk]. (PubMed id 11481859)4 Yamada H....Sunada Y. (Rinsho Shinkeigaku 2001)
    226. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PubMed id 11006133)1 Shimizu K....Hirai H. (Biochem. Biophys. Res. Commun. 2000)
    227. Identification of a novel mutation C144F in the Notch3 gene in an Australian CADASIL pedigree. (PubMed id 11058919)2 Grigg R....Griffiths L. (Hum. Mutat. 2000)
    228. Neurogenic genes and vertebrate neurogenesis. (PubMed id 8794055)1 Lewis J. (Curr. Opin. Neurobiol. 1996)
    229. The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation. (PubMed id 7698746)1 Larsson C.... Lendahl U. (Genomics 1994)
    230. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12. (PubMed id 8485581)1 Tournier-Lasserve E....Maciazek J. (Nat. Genet. 1993)
    231. CADASIL (PubMed id 20301673)1 Pagon R.A....Stephens K. (1993)
    232. Comparison of male and female kidney transplant survival rates. (PubMed id 4557798)1 Beleil O.M....Terasaki P.I. (Transplantation 1972)
    233. Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. (PubMed id 12756589)9 Lesnik Oberstein S.A....Haan J. (Acta Neuropathol. 2003)
    234. Two novel mutations of the NOTCH3 gene in Korean patients with CADASIL. (PubMed id 16256149)9 Kim Y....Yoo H.W. (Mutat. Res. 2006)
    235. Notch3 ectodomain is a major component of granular osmiophilic material (GOM) in CADASIL. (PubMed id 16871402)9 Ishiko A....Suzuki N. (Acta Neuropathol. 2006)
    236. Novel mutation of the Notch3 gene in a Japanese patient with CADASIL. (PubMed id 17389000)9 Oki K....Suzuki N. (Eur. J. Neurol. 2007)
    237. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: two novel mutations in the NOTCH3 gene in Chinese. (PubMed id 16580020)9 Lee Y.C....Soong B.W. (J. Neurol. Sci. 2006)
    238. CADASIL mutations impair Notch3 glycosylation by Fringe. (PubMed id 15857853)9 Arboleda-Velasquez J.F....Kosik K.S. (Hum. Mol. Genet. 2005)
    239. A novel NOTCH3 frameshift deletion and mitochondrial abnormalities in a patient with CADASIL. (PubMed id 15210536)9 Dotti M.T....Federico A. (Arch. Neurol. 2004)
    240. [NOTCH3 gene mutations in four Chinese families with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy]. (PubMed id 15387979)9 Wang Z.X....Yuan Y. (Zhonghua Yi Xue Za Zhi 2004)
    241. Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 12507916)9 Ruchoux M.M....Joutel A. (Am. J. Pathol. 2003)
    242. [Vascular hereditary dementia CADASIL type in Colombia. III. Linkage analysis to notch3 gene]. (PubMed id 11391502)9 Arcos-Burgos O.M....Lopera Restrepo F. (Rev Neurol 2001)
    243. [Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)]. (PubMed id 19363995)9 Ueda M....Ando Y. (Rinsho Byori 2009)
    244. Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. (PubMed id 17332745)9 Bellavia D....Screpanti I. (EMBO J. 2007)
    245. CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk. (PubMed id 15350543)9 Peters N....Dichgans M. (Exp. Cell Res. 2004)
    246. Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk. (PubMed id 17881497)9 ClAcment N....Limon I. (J. Cell. Sci. 2007)
    247. The R110C mutation in Notch3 causes variable clinical features in two Turkish families with CADASIL syndrome. (PubMed id 16730748)9 Uyguner Z.O....Wollnik B. (J. Neurol. Sci. 2006)
    248. CADASIL with a novel mutation in exon 7 of NOTCH3 (C388Y). (PubMed id 16974063)9 Ishida C....Yamada M. (Intern. Med. 2006)
    249. Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL. (PubMed id 14667809)9 Donahue C.P. and Kosik K.S. (Genomics 2004)
    250. [Clinical, radiological, histopathological and genetic findings in a Danish &quot;CADASIL&quot; family]. (PubMed id 10766655)9 Binzer M.N....Stenager E. (Ugeskr. Laeg. 2000)
    251. Identification of a Notch3 mutation in a Japanese CADASIL family. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 10609671)9 Kamimura K....Tabira T. (Alzheimer Dis Assoc Disord 1999)
    252. Identification of a key recombinant narrows the CADASIL gene region to 8 cM and argues against allelism of CADASIL and familial hemiplegic migraine. (PubMed id 8786108)9 Dichgans M....Gasser T. (Genomics 1996)
    253. Autosomal dominant migraine with MRI white-matter abnormalities mapping to the CADASIL locus. (PubMed id 7783868)9 Chabriat H....Tehindrazanarivelo A. (Neurology 1995)
    254. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. (PubMed id 18182388)9 Li K....Zhou B.B. (J. Biol. Chem. 2008)
    255. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. (PubMed id 18250475)9 Jurynczyk M....Selmaj K. (J. Immunol. 2008)
    256. Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL. (PubMed id 17235124)9 Low W.C....Kalaria R.N. (Brain 2007)
    257. A novel hereditary small vessel disease of the brain. (PubMed id 16404745)9 Verreault S....Chabriat H. (Ann. Neurol. 2006)
    258. The spectrum of Notch3 mutations in 28 Italian CADASIL families. (PubMed id 15834039)9 Dotti M.T....Quattrone A. (J. Neurol. Neurosurg. Psychiatr. 2005)
    259. Two Japanese CADASIL families with a R141C mutation in the Notch3 gene. (PubMed id 11757773)9 Murakami T....Abe K. (Intern. Med. 2001)
    260. A novel mitochondrial DNA mutation and a mutation in the Notch3 gene in a patient with myopathy and CADASIL. (PubMed id 11715067)9 FinnilAo S....Majamaa K. (J. Mol. Med. 2001)
    261. [CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy): clinical features and neuroimaging]. (PubMed id 11261256)9 Chabriat H....Bousser M.G. (Bull. Acad. Natl. Med. 2000)
    262. Notch signaling in pulmonary hypertension. (PubMed id 20204737)9 Thistlethwaite P.A....Zhang X. (Adv. Exp. Med. Biol. 2010)
    263. Apoptosis in CADASIL: an in vitro study of lymphocytes and fibroblasts from a cohort of Italian patients. (PubMed id 19180562)9 Formichi P....Federico A. (J. Cell. Physiol. 2009)
    264. Notch signaling and CADASIL. (PubMed id 19673359)9 Tang S.C....Yip P.K. (Acta Neurol Taiwan 2009)
    265. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. (PubMed id 19640841)9 Rauen T....Mertens P.R. (J. Biol. Chem. 2009)
    266. EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma. (PubMed id 18757425)9 Ban J....Kovar H. (Cancer Res. 2008)
    267. A novel mutation (C271F) in the Notch3 gene in a Chinese man with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 16949066)9 Au K.M....Chan A.Y. ( international journal of clinical chemistry 2007)
    268. Putative role of specific JAG1 gene exons in modulating clinical features in patients with leukoencephalopathy. (PubMed id 17368936)9 Ungaro C....Mazzei R. (Neurosci. Lett. 2007)
    269. CADASIL-causing mutations do not alter Notch3 receptor processing and activation. (PubMed id 16791082)9 Low W.C....Kalaria R.N. (Neuroreport 2006)
    270. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). (PubMed id 15876982)9 Lesnik Oberstein S.A. and Haan J. (Panminerva Med 2004)
    271. Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family. (PubMed id 11591842)9 de la PeA+a P....Garesse R. (Neurology 2001)
    272. Mutations of the notch3 gene in non-caucasian patients with suspected CADASIL syndrome. (PubMed id 11244211)9 Kotorii S....Tabira T. (Dement Geriatr Cogn Disord 2001)
    273. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy): an Australian perspective. (PubMed id 11535004)9 Chuah T.L....Lander C. (J Clin Neurosci 2001)
    274. Arg133Cys mutation of Notch3 in two unrelated Japanese families with CADASIL. (PubMed id 10969905)9 Uyama E....Uchino M. (Intern. Med. 2000)
    275. CADASIL: hereditary disease of arteries causing brain infarcts and dementia. (PubMed id 10476042)9 Kalimo H....Winblad B. (Neuropathol. Appl. Neurobiol. 1999)
    276. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, genetic homogeneity, and mapping of the locus within a 2-cM interval. (PubMed id 8554054)9 Ducros A....Delrieu O. (Am. J. Hum. Genet. 1996)
    277. [CADASIL]. (PubMed id 19069156)9 Uchino M. (Brain Nerve 2008)
    278. Amplicon profiles in ovarian serous carcinomas. (PubMed id 17351921)9 Nakayama K....Wang T.L. (Int. J. Cancer 2007)
    279. Lacunar infarcts are the main correlate with cognitive dysfunction in CADASIL. (PubMed id 17272761)9 Liem M.K....Lesnik Oberstein S.A. ( a journal of cerebral circulation 2007)
    280. Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene. (PubMed id 16864835)9 Saiki S....Hirose G. (Neurology 2006)
    281. The prevalence of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) in the west of Scotland. (PubMed id 15834040)9 Razvi S.S....Muir K.W. (J. Neurol. Neurosurg. Psychiatr. 2005)
    282. Incipient CADASIL. (PubMed id 12756134)9 Lesnik Oberstein S.A....Haan J. (Arch. Neurol. 2003)
    283. Cerebral hemodynamics and white matter hyperintensities in CADASIL. (PubMed id 12771575)9 van den Boom R....van Buchem M.A. (J. Cereb. Blood Flow Metab. 2003)
    284. Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. (PubMed id 11745340)9 JAPnsson J.I....Nilsson G. (Eur. J. Immunol. 2001)
    285. [Two case reports of cerebral autosomal dominant arteriophaty with subcortical infarctions and leukoencephalopathy (CADASIL)]. (PubMed id 11675581)9 PellicanA^ S....Terra L. (Minerva Med. 2001)
    286. A CADASIL case with normal skin biopsy and without mutations in exons 3 and 4 of the Notch3 gene. (PubMed id 11718749)9 de Freitas G.R....Bogousslavsky J. (J. Neurol. Sci. 2001)
    287. [From gene to disease; from Notch3 to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy]. (PubMed id 11257815)9 Oberstein S.A....Haan J. (Ned Tijdschr Geneeskd 2001)
    288. An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). (PubMed id 11136906)9 Fryxell K.J....Jordan T.V. ( a journal of cerebral circulation 2001)
    289. Migraine with aura and white matter abnormalities: Notch3 mutation. (PubMed id 10802804)9 Ceroni M....Carrera P. (Neurology 2000)
    290. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 10717413)9 UnlA1 M....St Clair D. (Neurosci. Lett. 2000)
    291. [CADASIL: genetics and physiopathology]. (PubMed id 11261257)9 Joutel A....Tournier-Lasserve E. (Bull. Acad. Natl. Med. 2000)
    292. Acetazolamide improves cerebral hemodynamics in CADASIL. (PubMed id 20227091)9 Huang L....Wang H. (J. Neurol. Sci. 2010)
    293. Childhood-onset CADASIL: clinical, imaging, and neurocognitive features. (PubMed id 20197270)9 Hartley J....Yoon G. (J. Child Neurol. 2010)
    294. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a genetic cause of cerebral small vessel disease. (PubMed id 20386637)9 Choi J.C. (J Clin Neurol 2010)
    295. Evaluation of brain apoptosis in a CADASIL postmortem case. (PubMed id 19788051)9 Battisti C....Federico A. (Clin. Neuropathol. 2009)
    296. Molecular genetics of migraine. (PubMed id 19455354)9 de Vries B....van den Maagdenberg A.M. (Hum. Genet. 2009)
    297. On the diagnosis of CADASIL. (PubMed id 19542611)9 Ampuero I....de YAcbenes J.G. (J. Alzheimers Dis. 2009)
    298. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): a patient from Sri Lanka. (PubMed id 19683925)9 De Silva K.R....Mizuno T. (J Clin Neurosci 2009)
    299. Magnetic resonance findings in leucodystrophies and MS. (PubMed id 19671368)9 Labauge P. (Int MS J 2009)
    300. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy resulting in stroke in an 11-year-old male. (PubMed id 19207299)9 Granild-Jensen J....Hansen U.S. (Dev Med Child Neurol 2009)
    301. Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life? (PubMed id 19419383)9 Yuan P....Manji H.K. (Bipolar Disord 2009)
    302. Nerve conduction studies in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. (PubMed id 19488673)9 Kang S.Y....Lee J.S. (J. Neurol. 2009)
    303. Cadasil. (PubMed id 19539236)9 Chabriat H....Bousser M.G. (Lancet Neurol 2009)
    304. Glycogene expression in conjunctiva of patients with dry eye: downregulation of Notch signaling. (PubMed id 19011014)9 Mantelli F....ArgA1eso P. (amp 2009)
    305. Autosomal dominant leukoencephalopathy with mild clinical symptoms due to cerebrovascular dysfunctions: a new disease entity? (PubMed id 17656057)9 Hirabayashi S....Arima K. (amp 2008)
    306. Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL. (PubMed id 18537053)9 Peters N....Dichgans M. (J. Neurol. 2008)
    307. Homozygosity for a NOTCH3 mutation in a 65-year-old CADASIL patient with mild symptoms: a family report. (PubMed id 19153638)9 Liem M.K....Helderman-van den Enden A.T. (J. Neurol. 2008)
    308. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. (PubMed id 18156632)9 Bai S....Teitelbaum S.L. (J. Biol. Chem. 2008)
    309. Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL. (PubMed id 17620550)9 Viswanathan A....Chabriat H. (Neurology 2007)
    310. Neuropsychiatric manifestations in CADASIL. (PubMed id 17726918)9 Chabriat H. and Bousser M.G. (Dialogues Clin Neurosci 2007)
    311. Genetics of ischaemic stroke. (PubMed id 17239802)9 Dichgans M. (Lancet Neurol 2007)
    312. Notch and Ikaros: not only converging players in T cell leukemia. (PubMed id 18032925)9 Bellavia D....Screpanti I. (Cell Cycle 2007)
    313. Cytoskeletal structure in cells harboring two mutations: R133C in NOTCH3 and 5650G&gt;A in mitochondrial DNA. (PubMed id 17276737)9 Annunen-Rasila J....Majamaa K. (Mitochondrion 2007)
    314. Proteome analysis of cultivated vascular smooth muscle cells from a CADASIL patient. (PubMed id 17622327)9 Ihalainen S....Baumann M. (Mol. Med. 2007)
    315. A novel CADASIL-causing mutation in a stroke patient. (PubMed id 17629811)9 Vikelis M....Karageorgiou C.E. (Swiss Med Wkly 2007)
    316. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. (PubMed id 16688224)9 Palomero T....Ferrando A.A. (Leukemia 2006)
    317. Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis. (PubMed id 16368887)9 Talora C....Screpanti I. (Blood 2006)
    318. Skin biopsy findings and results of neuropsychological testing in the first confirmed cases of CADASIL in Norway. (PubMed id 16643313)9 Rein Gustavsen W....Schlosser A. (Eur. J. Neurol. 2006)
    319. The genetic studies of dementias in Taiwan. (PubMed id 16599291)9 Chen H.H. and Hu C.J. (Acta Neurol Taiwan 2006)
    320. Unexpected features of acute T lymphoblastic lymphomas in Notch1IC transgenic rats. (PubMed id 16838279)9 van den Brandt J....Reichardt H.M. (Eur. J. Immunol. 2006)
    321. Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers. (PubMed id 17008614)9 Opherk C....Dichgans M. ( a journal of cerebral circulation 2006)
    322. [Case of CADASIL showing spontaneous subcortical hemorrhage with a novel mutation of Notch3 gene]. (PubMed id 17260807)9 Kotorii S....Shibuya N. (Rinsho Shinkeigaku 2006)
    323. Genetic characteristics of dementia in Taiwan. (PubMed id 16995595)9 Chen H.H. and Hu C.J. (Acta Neurol Taiwan 2006)
    324. [CADASIL with minimal symptoms after 60 years]. (PubMed id 17028543)9 Mourad A....Chabriat H. (Rev. Neurol. (Paris) 2006)
    325. Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study. (PubMed id 16844717)9 Viswanathan A....Chabriat H. (Brain 2006)
    326. Electrocardiogram in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy patients without any clinical evidence of coronary artery disease: a case-control study. (PubMed id 16514092)9 Cumurciuc R....Vahedi K. ( a journal of cerebral circulation 2006)

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     antibodies-online antibodies for NOTCH3 (78 products)
     antibodies-online kits for NOTCH3 (3 products)
     antibodies-online peptides for NOTCH3
     antibodies-online proteins for NOTCH3
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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