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Aliases for NOTCH2NL Gene

Aliases for NOTCH2NL Gene

  • Notch 2 N-Terminal Like 2 3 5
  • N2N 3 4
  • Notch Homolog 2 (Drosophila) N-Terminal Like 2
  • Notch Homolog 2 N-Terminal Like Protein 3

External Ids for NOTCH2NL Gene

Previous GeneCards Identifiers for NOTCH2NL Gene

  • GC01P142699
  • GC01P143920
  • GC01P145209

Summaries for NOTCH2NL Gene

GeneCards Summary for NOTCH2NL Gene

NOTCH2NL (Notch 2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DLK1.

UniProtKB/Swiss-Prot for NOTCH2NL Gene

  • May function in the Notch signaling pathway and regulate neutrophil differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOTCH2NL Gene

Genomics for NOTCH2NL Gene

Regulatory Elements for NOTCH2NL Gene

Promoters for NOTCH2NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOTCH2NL on UCSC Golden Path with GeneCards custom track

Genomic Location for NOTCH2NL Gene

146,146,203 bp from pter
146,229,032 bp from pter
82,830 bases
Minus strand

Genomic View for NOTCH2NL Gene

Genes around NOTCH2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOTCH2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOTCH2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTCH2NL Gene

Proteins for NOTCH2NL Gene

  • Protein details for NOTCH2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Notch homolog 2 N-terminal-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5BKT8
    • Q5VTG9
    • Q5XG84
    • Q6P192
    • Q8NC23
    • Q8WUQ9
    • Q96FY1

    Protein attributes for NOTCH2NL Gene

    236 amino acids
    Molecular mass:
    25835 Da
    Quaternary structure:
    • Interacts with ELANE.
    • Sequence=AAH84572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11381.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NOTCH2NL Gene


neXtProt entry for NOTCH2NL Gene

Proteomics data for NOTCH2NL Gene at MOPED

Post-translational modifications for NOTCH2NL Gene

Other Protein References for NOTCH2NL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NOTCH2NL Gene

Domains & Families for NOTCH2NL Gene

Suggested Antigen Peptide Sequences for NOTCH2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EGF-like domains.
  • Belongs to the NOTCH family.
  • Contains 6 EGF-like domains.
  • Belongs to the NOTCH family.
genes like me logo Genes that share domains with NOTCH2NL: view

No data available for Gene Families for NOTCH2NL Gene

Function for NOTCH2NL Gene

Molecular function for NOTCH2NL Gene

UniProtKB/Swiss-Prot Function:
May function in the Notch signaling pathway and regulate neutrophil differentiation.
genes like me logo Genes that share phenotypes with NOTCH2NL: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOTCH2NL Gene

Localization for NOTCH2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTCH2NL Gene

Secreted. Cytoplasm.

Subcellular locations from

Jensen Localization Image for NOTCH2NL Gene COMPARTMENTS Subcellular localization image for NOTCH2NL gene
Compartment Confidence
extracellular 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NOTCH2NL Gene

Pathways & Interactions for NOTCH2NL Gene

SuperPathways for NOTCH2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOTCH2NL Gene


No data available for Pathways by source and SIGNOR curated interactions for NOTCH2NL Gene

Drugs & Compounds for NOTCH2NL Gene

No Compound Related Data Available

Transcripts for NOTCH2NL Gene

Unigene Clusters for NOTCH2NL Gene

Notch 2 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOTCH2NL Gene

No ASD Table

Relevant External Links for NOTCH2NL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOTCH2NL Gene

mRNA expression in normal human tissues for NOTCH2NL Gene

SOURCE GeneReport for Unigene cluster for NOTCH2NL Gene Hs.655156

mRNA Expression by UniProt/SwissProt for NOTCH2NL Gene

Tissue specificity: Widely expressed with higher levels in leukocytes and lymph nodes.
genes like me logo Genes that share expression patterns with NOTCH2NL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NOTCH2NL Gene

Orthologs for NOTCH2NL Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NOTCH2NL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOTCH2NL 35
  • 95.72 (n)
  • 93.58 (a)
Species with no ortholog for NOTCH2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOTCH2NL Gene

Gene Tree for NOTCH2NL (if available)
Gene Tree for NOTCH2NL (if available)

Paralogs for NOTCH2NL Gene

Paralogs for NOTCH2NL Gene

(12) SIMAP similar genes for NOTCH2NL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NOTCH2NL: view

Variants for NOTCH2NL Gene

Sequence variations from dbSNP and Humsavar for NOTCH2NL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10910779 - 146,164,850(-) CGACA(C/T)CTCAT reference, missense
rs8002 - 146,156,641(-) TGGCA(A/C/T)CTGCC reference, missense
rs4649852 - 146,156,528(-) GAGGC(A/T)CCTGT reference, missense
VAR_043604 -
rs391102 -- 146,170,926(-) CTACT(A/C/G)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOTCH2NL Gene

Variant ID Type Subtype PubMed ID
nsv428212 CNV Gain 18775914
nsv872203 CNV Gain 21882294
dgv104e1 CNV Complex 17122850
nsv7181 OTHER Inversion 18451855
nsv436028 CNV Insertion 17901297
esv2717206 CNV Deletion 23290073
dgv66e199 CNV Deletion 23128226
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
nsv510962 CNV Complex 20534489
nsv509457 CNV Insertion 20534489
dgv105e1 CNV Complex 17122850
dgv107e1 CNV Complex 17122850
dgv108e1 CNV Complex 17122850
nsv872222 CNV Gain 21882294
dgv111e1 CNV Complex 17122850
essv18481 CNV CNV 17122850
nsv2655 CNV Loss 18451855
nsv469755 CNV Loss 16826518
esv27127 CNV Gain 19812545
nsv824442 CNV Gain 20364138
nsv8091 CNV Gain 18304495
nsv831337 CNV Loss 17160897
nsv820512 CNV Duplication 20802225
nsv831348 CNV Loss 17160897
esv269263 CNV Insertion 20981092
nsv824453 CNV Gain 20364138
esv2422428 CNV Duplication 17116639
nsv2677 CNV Loss 18451855
esv2717385 CNV Deletion 23290073
nsv508582 CNV Loss 20534489

Variation tolerance for NOTCH2NL Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOTCH2NL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTCH2NL Gene

Disorders for NOTCH2NL Gene

Relevant External Links for NOTCH2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOTCH2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOTCH2NL Gene

Publications for NOTCH2NL Gene

  1. A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. (PMID: 14673143) Duan Z. … Horwitz M. (Mol. Cell. Biol. 2004) 2 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NOTCH2NL Gene

Sources for NOTCH2NL Gene

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