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Aliases for NOTCH2NL Gene

Aliases for NOTCH2NL Gene

  • Notch 2 N-Terminal Like 2 3 5
  • N2N 3 4
  • Notch Homolog 2 (Drosophila) N-Terminal Like 2
  • Notch Homolog 2 N-Terminal-Like Protein 3
  • Notch Homolog 2 N-Terminal Like Protein 3

External Ids for NOTCH2NL Gene

Previous GeneCards Identifiers for NOTCH2NL Gene

  • GC01P142699
  • GC01P143920
  • GC01P145209

Summaries for NOTCH2NL Gene

GeneCards Summary for NOTCH2NL Gene

NOTCH2NL (Notch 2 N-Terminal Like) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino). GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DLK1.

UniProtKB/Swiss-Prot for NOTCH2NL Gene

  • May function in the Notch signaling pathway and regulate neutrophil differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOTCH2NL Gene

Genomics for NOTCH2NL Gene

Regulatory Elements for NOTCH2NL Gene

Enhancers for NOTCH2NL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F146209 1.5 FANTOM5 Ensembl ENCODE 25.1 +16.8 16832 5.2 ZNF146 RNF2 JUN ZNF318 ZNF316 SMARCA4 PRDM10 EMSY MAFK NOTCH2NL NBPF10 PIR33330 PIR39582
GH01F145976 1 FANTOM5 ENCODE 18.7 +247.0 247047 10.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR3C ANKRD35 NOTCH2NL HFE2 RBM8A LIX1L-AS1 PEX11B GNRHR2 LIX1L TXNIP
GH01F146034 0.6 Ensembl ENCODE 18 +191.5 191455 5.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 ZFP41 POLR3C NOTCH2NL ANKRD35 NUDT17 TXNIP GNRHR2 LINC01719 NBPF12 HFE2 TRG-TCC2-1
GH01F146248 1.5 FANTOM5 Ensembl 17.9 -19.1 -19070 1.8 KLF1 TAL1 CEBPB DPF2 ARID1B ZBTB48 NBN FOS ZNF600 PRDM1 NOTCH2NL NBPF10 LOC105371254 LOC105371249
GH01F146050 0.8 ENCODE 17.3 +177.3 177324 2.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D POLR3C NOTCH2NL ANKRD35 LINC01719 GC01M146050 RNVU1-6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NOTCH2NL on UCSC Golden Path with GeneCards custom track

Promoters for NOTCH2NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001039962 832 3201 HDGF SIN3A FEZF1 ZNF2 ZNF302 ZNF143 ZNF548 KLF13 SP3 REST

Genomic Location for NOTCH2NL Gene

Chromosome:
1
Start:
146,146,203 bp from pter
End:
146,229,032 bp from pter
Size:
82,830 bases
Orientation:
Minus strand

Genomic View for NOTCH2NL Gene

Genes around NOTCH2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOTCH2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOTCH2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTCH2NL Gene

Proteins for NOTCH2NL Gene

  • Protein details for NOTCH2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3S9-NT2NL_HUMAN
    Recommended name:
    Notch homolog 2 N-terminal-like protein
    Protein Accession:
    Q7Z3S9
    Secondary Accessions:
    • Q5BKT8
    • Q5VTG9
    • Q5XG84
    • Q6P192
    • Q8NC23
    • Q8WUQ9
    • Q96FY1

    Protein attributes for NOTCH2NL Gene

    Size:
    236 amino acids
    Molecular mass:
    25835 Da
    Quaternary structure:
    • Interacts with ELANE.
    SequenceCaution:
    • Sequence=AAH84572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11381.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NOTCH2NL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOTCH2NL Gene

Post-translational modifications for NOTCH2NL Gene

Other Protein References for NOTCH2NL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NOTCH2NL
  • Cloud-Clone Corp. Antibodies for NOTCH2NL

No data available for DME Specific Peptides for NOTCH2NL Gene

Domains & Families for NOTCH2NL Gene

Suggested Antigen Peptide Sequences for NOTCH2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3S9

UniProtKB/Swiss-Prot:

NT2NL_HUMAN :
  • Contains 6 EGF-like domains.
  • Belongs to the NOTCH family.
Domain:
  • Contains 6 EGF-like domains.
Family:
  • Belongs to the NOTCH family.
genes like me logo Genes that share domains with NOTCH2NL: view

No data available for Gene Families for NOTCH2NL Gene

Function for NOTCH2NL Gene

Molecular function for NOTCH2NL Gene

UniProtKB/Swiss-Prot Function:
May function in the Notch signaling pathway and regulate neutrophil differentiation.

Gene Ontology (GO) - Molecular Function for NOTCH2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NOTCH2NL: view
genes like me logo Genes that share phenotypes with NOTCH2NL: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOTCH2NL Gene

Localization for NOTCH2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTCH2NL Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOTCH2NL Gene COMPARTMENTS Subcellular localization image for NOTCH2NL gene
Compartment Confidence
extracellular 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NOTCH2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NOTCH2NL: view

Pathways & Interactions for NOTCH2NL Gene

SuperPathways for NOTCH2NL Gene

SuperPathway Contained pathways
1 Notch Signaling Pathway (sino)
genes like me logo Genes that share pathways with NOTCH2NL: view

Pathways by source for NOTCH2NL Gene

1 Sino Biological pathway for NOTCH2NL Gene

Gene Ontology (GO) - Biological Process for NOTCH2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NOTCH2NL: view

No data available for SIGNOR curated interactions for NOTCH2NL Gene

Transcripts for NOTCH2NL Gene

Unigene Clusters for NOTCH2NL Gene

Notch 2 N-terminal like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOTCH2NL Gene

No ASD Table

Relevant External Links for NOTCH2NL Gene

GeneLoc Exon Structure for
NOTCH2NL
ECgene alternative splicing isoforms for
NOTCH2NL

Expression for NOTCH2NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOTCH2NL Gene

NURSA nuclear receptor signaling pathways regulating expression of NOTCH2NL Gene:

NOTCH2NL

SOURCE GeneReport for Unigene cluster for NOTCH2NL Gene:

Hs.655156

mRNA Expression by UniProt/SwissProt for NOTCH2NL Gene:

Q7Z3S9-NT2NL_HUMAN
Tissue specificity: Widely expressed with higher levels in leukocytes and lymph nodes.
genes like me logo Genes that share expression patterns with NOTCH2NL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NOTCH2NL Gene

Orthologs for NOTCH2NL Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NOTCH2NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOTCH2NL 34
  • 95.72 (n)
Species where no ortholog for NOTCH2NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOTCH2NL Gene

ENSEMBL:
Gene Tree for NOTCH2NL (if available)
TreeFam:
Gene Tree for NOTCH2NL (if available)

Paralogs for NOTCH2NL Gene

Paralogs for NOTCH2NL Gene

(12) SIMAP similar genes for NOTCH2NL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NOTCH2NL: view

Variants for NOTCH2NL Gene

Sequence variations from dbSNP and Humsavar for NOTCH2NL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10399807 -- 146,169,243(-) TAGAT(A/C/G/T)GGGAA intron-variant
rs10429826 -- 146,207,288(-) tggac(A/G)tggtg intron-variant
rs10429827 -- 146,207,725(-) ACCAC(A/G)AATGG intron-variant
rs1053710 --
rs1053717 -- 146,156,166(+) AGAAC(A/C/G)CGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NOTCH2NL Gene

Variant ID Type Subtype PubMed ID
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv3540367 CNV deletion 23714750
esv3540378 CNV deletion 23714750
esv3571119 CNV gain 25503493
esv3571231 CNV gain 25503493
esv3578143 CNV loss 25503493
esv3578144 CNV loss 25503493
esv3578145 CNV loss 25503493
esv3578146 CNV loss 25503493
esv3578147 CNV loss 25503493
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1077298 CNV duplication 25765185
nsv1132304 CNV duplication 24896259
nsv1132305 CNV duplication 24896259
nsv1132306 CNV duplication 24896259
nsv1147576 CNV duplication 26484159
nsv1151944 CNV duplication 26484159
nsv2677 CNV deletion 18451855
nsv508582 CNV deletion 20534489
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv8091 CNV gain 18304495
nsv831337 CNV loss 17160897
nsv831348 CNV loss 17160897

Variation tolerance for NOTCH2NL Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOTCH2NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOTCH2NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTCH2NL Gene

Disorders for NOTCH2NL Gene

Relevant External Links for NOTCH2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOTCH2NL

No disorders were found for NOTCH2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOTCH2NL Gene

Publications for NOTCH2NL Gene

  1. A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. (PMID: 14673143) Duan Z. … Horwitz M. (Mol. Cell. Biol. 2004) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for NOTCH2NL Gene

Sources for NOTCH2NL Gene

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