Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOTCH2 Gene

protein-coding   GIFtS: 69
GCID: GC01M120454

notch 2

(Previous names: Notch (Drosophila) homolog 2, Notch homolog 2 (Drosophila)...)
 Explore 60 diseases affiliated with
NOTCH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NOTCH2    

Aliases
for NOTCH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Notch 21 2 3     Notch Homolog 2 (Drosophila)1
HN21     HJCYS2
AGS22 5     Neurogenic Locus Notch Homolog Protein 22
Notch (Drosophila) Homolog 21     Notch Homolog 22

External Ids:    HGNC: 78821   Entrez Gene: 48532   Ensembl: ENSG000001342507   OMIM: 6002755   UniProtKB: Q047213   

Export aliases for NOTCH2 gene to outside databases

Previous GC identifers: GC01M120900 GC01M119292 GC01M119601 GC01M119800 GC01M120100 GC01M120256 GC01M118312


Summaries
for NOTCH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NOTCH2:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural
characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats,
and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a
variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an
evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent
cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular
signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in
human, but precise interactions between these ligands and the human notch homologues remain to be determined. This
protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein
functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721
Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the
implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling
and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates
RANKL-induced osteoclast differentiation

Gene Wiki entry for NOTCH2 (Notch-2)


Genomic Views
for NOTCH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOTCH2 gene promoter:
         Elk-1   AML1a   IRF-1   Tal-1beta   C/EBPalpha   MEF-2A   Nkx6-1   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): NOTCH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOTCH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOTCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13-p11   Ensembl cytogenetic band:  1p11.2   HGNC cytogenetic band: 1p13-p11

NOTCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOTCH2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M120454:  view genomic region     (about GC identifiers)

Start:
 120,454,176 bp from pter      End:
 120,612,276 bp from pter
Size:
 158,101 bases      Orientation:
 minus strand

Proteins
for NOTCH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721 (See protein sequence)
Recommended Name: Neurogenic locus notch homolog protein 2 precursor  
Size: 2471 amino acids; 265405 Da
Subunit: Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by
disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for
NOTCH2. Interacts with RELA/p65 (By similarity). Interacts with HIF1AN
Subcellular location: Cell membrane; Single-pass type I membrane protein
Subcellular location: Notch 2 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is
translocated to the nucleus
1 PDB 3D structure from and Proteopedia for NOTCH2:
2OO4 (3D)    
Secondary accessions: Q5T3X7 Q99734 Q9H240

Explore the universe of human proteins at neXtProt for NOTCH2: NX_Q04721

Post-translational modifications:

  • Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like
    • convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible
    form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is
    cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch
    extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a
    notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity)1
  • Hydroxylated by HIF1AN1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04721

    • NOTCH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186930.1  NP_077719.2  

    ENSEMBL proteins: 
     ENSP00000256646  
    Reactome Protein details: Q04721
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NOTCH2 (Notch-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for NOTCH2 
    GenScript Custom Purified and Recombinant Proteins Services for NOTCH2
    Novus Biologicals NOTCH2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NOTCH2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA1303260
    GO:0005654nucleoplasm TAS--
    GO:0005789endoplasmic reticulum membrane TAS--


    NOTCH2 for ontologies           About GeneDecksing



    NOTCH2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NOTCH2
    R&D Systems Antibodies for NOTCH2 (Notch-2)
    Cell Signaling Technology (CST) Antibodies for NOTCH2  (Notch 2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NOTCH2 
    GenScript Custom Superior Antibodies Services for NOTCH2
    Novus Biologicals NOTCH2 Antibodies
    Abcam antibodies for NOTCH2 
    Uscn Antibodies for NOTCH2
    ThermoFisher Antibodies for NOTCH2

    Assay Products for NOTCH2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOTCH2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NOTCH2

    Protein Domains /
    Families
    for NOTCH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOTCH2 for domains           About GeneDecksing

    5/13 InterPro domains/families (see all 13):
     IPR010660 Notch_NOD_dom
     IPR024600 DUF3454_notch
     IPR001881 EGF-like_Ca-bd
     IPR008297 Notch
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q04721

    ProtoNet protein and cluster: Q04721

    5 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000800 LIN-12/notch repeat (LNR) signature
    IPB001438 Type II EGF-like signature
    IPB001881 EGF-like calcium-binding
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721
    Similarity: Belongs to the NOTCH family
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 35 EGF-like domains
    Similarity: Contains 3 LNR (Lin/Notch) repeats


    Function
    for NOTCH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721
    Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
    determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
    transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the
    implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling
    and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates
    RANKL-induced osteoclast differentiation

         Genatlas biochemistry entry for NOTCH2:
    Drosophila Notch homolog 2,mediating cell-cell interactions that specify cell fate during development,undergoing a
    first proteolytic cleavage by furin (PACE1) in the Golgi during trafficking of Notch to the cell surface,undergoing
    further cleavage by gamma secretase (see PSEN1) releasing an intracellular domain (NICD) which translocates to the
    nucleus and modulates transcription of target genes,putatively involved in neoplasia associated translocations

         Summary:  
    During embryonic development, NOTCH2 as signaling molecule is secreted from the following cells: XX Germ Cells in Ovigerous Cord It affects the following cells: Pre-Granulosa Cells in Primordial Follicle

    miRNA
    Products:            		miRTarBase miRNAs that target NOTCH2:
    hsa-mir-16 (MIRT001437), hsa-mir-1 (MIRT001353), hsa-mir-34a (MIRT005029), hsa-mir-326 (MIRT004425), hsa-mir-181c (MIRT003209)

    OriGene 3'-UTR Clone: NOTCH2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOTCH2
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate NOTCH2 (see all 84):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-485-3p hsa-miR-374a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NOTCH2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTCH2 (see all 7)
    OriGene shRNA RFP: NOTCH2
    OriGene siRNA: NOTCH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTCH2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NOTCH2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NOTCH2 (NM_024408)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTCH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTCH2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NOTCH2
    Search LifeMap BioReagents cell lines for NOTCH2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS9244302
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI11101851


    NOTCH2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NOTCH2: Notch2tm3.1Grid Notch2tm2Grid Notch2tm1Grid Notch2tm2Hhi
         15/23 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Notch2) (see all 23):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    NOTCH2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NOTCH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mature NOTCH heterodimer traffics to the plasma membrane
    		Mature NOTCH heterodimer traffics to the plasma membrane1.00
    		A third proteolytic cleavage releases NICD0.44
    		Transport of fringe-modified NOTCH to plasma membrane1.00
    		NICD traffics to nucleus0.31
    		Transport of NOTCH precursor to Golgi1.00
    		Notch-HLH transcription pathway0.31
    		Pre-NOTCH Processing in the Endoplasmic Reticulum0.67
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    		NOTCH2 Activation and Transmission of Signal to the Nucleus1.00
    		Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor0.43
    		Signaling by NOTCH21.00
    3Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Delta-Notch Signaling Pathway0.27
    		Notch signaling pathway0.82
    4Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    5Pre-NOTCH Processing in Golgi
    		Pre-NOTCH Processing in Golgi1.00
    		Pre-NOTCH Expression and Processing0.55

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NOTCH2
        Notch Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Epithelial Adherens Junctions

    3 Cell Signaling Technology (CST) Pathways for NOTCH2
        Wnt / Hedgehog / Notch
    Angiogenesis
    Neuroscience

    4 BioSystems Pathways for NOTCH2 
        Neural Crest Differentiation
    Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Notch signaling pathway

    5/18        Reactome Pathways for NOTCH2 (see all 18)
        Pre-NOTCH Expression and Processing
    A third proteolytic cleavage releases NICD
    Notch-HLH transcription pathway
    Signaling by NOTCH2
    Signal Transduction


    2         Kegg Pathways  (Kegg details for NOTCH2):
        Dorso-ventral axis formation
    Notch signaling pathway


    NOTCH2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOTCH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for NOTCH2 (Q047212, 3 ENSP000002566464) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001709cell fate determination TAS9244302
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0002437inflammatory response to antigenic stimulus IEA--
    GO:0003184pulmonary valve morphogenesis IMP16773578


    NOTCH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOTCH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOTCH2
    Search CenterWatch for drugs/clinical trials and news about NOTCH2 / NOTC2 

    Transcripts
    for NOTCH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOTCH2 gene (2 alternative transcripts): 
    NM_001200001.1  NM_024408.3  

    Unigene Cluster for NOTCH2:

    Notch 2
    Hs.487360  [show with all ESTs]
    Unigene Representative Sequence: NM_024408
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256646(uc021osy.1 uc001eik.3 uc001eil.3 uc001eim.4)
    ENST00000493703 ENST00000478864 ENST00000479412 ENST00000489731

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NOTCH2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOTCH2
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate NOTCH2 (see all 84):
    hsa-miR-548j hsa-miR-579 hsa-miR-146a hsa-miR-15a hsa-miR-218-1* hsa-miR-485-3p hsa-miR-374a hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NOTCH2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTCH2 (see all 7)
    OriGene shRNA RFP: NOTCH2
    OriGene siRNA: NOTCH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTCH2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NOTCH2 (NM_024408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTCH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTCH2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTCH2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOTCH2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTCH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTCH2

    Additional cDNA sequence: 

    AF308601.1 AF315356.1 AK027869.1 AK307843.1 AL049386.1 AL133036.1 BC071562.1 GQ231534.1 
    U77493.1 

    22 DOTS entries:

    DT.97837624  DT.453995  DT.97859603  DT.91725275  DT.121448121  DT.95330154  DT.121448068  DT.91639065 
    DT.95118850  DT.95249493  DT.121435635  DT.121448048  DT.100645100  DT.100844596  DT.440461  DT.92468886 
    DT.95113504  DT.121435354  DT.121435400  DT.121435413  DT.121435859  DT.121448099 

    24/379 AceView cDNA sequences (see all 379):

    F03795 AW661928 BF797482 BE350245 H69945 AW468075 AW054433 CB043882 
    AI276327 BF887852 AA827551 BI038341 AW771162 AI784542 BP375766 AL042063 
    Z42377 BQ229392 AI093109 F13063 AF315356 BQ677636 AW075292 BQ678511 

    GeneLoc Exon Structure


    Expression
    for NOTCH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOTCH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCTCTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NOTCH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/57 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 57) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOutflow TractCardiomyocytesMyocardium
    KidneyRenal VesicleDistal Renal Vesicle CellsKidney
    KidneyRenal VesicleProximal Renal Vesicle CellsKidney
    KidneyS-shaped Body Distal SegmentS-shaped Body Distal CellsKidney
    KidneyS-shaped Body Medial SegmentS-shaped Body Medial CellsKidney
    KidneyS-shaped Body Proximal SegmentS-shaped Body Proximal CellsKidney
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Dorsal MusclesMyoblastsSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NOTCH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOTCH2

    SOURCE GeneReport for Unigene cluster: Hs.487360

    UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721
    Tissue specificity: Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in
    the embryo

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOTCH2 (see all 11): 
              Neurogenesis in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTCH2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOTCH2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTCH2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTCH2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH2

    Orthologs
    for NOTCH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NOTCH2 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NOTCH21 notch 2 74.11(n)
    77.16(a)    		   374031  NM_001252033.1  NP_001238962.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii notch21 notch homolog 2 61.05(n)
    58.89(a)    		   58065  NM_001115094.1  NP_001108566.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta N3 determination of glial fate transmembrane
    receptor    		 49(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea W02C12.13 EGF-like protein 38(a)
    (best of 9)    		   IV(4008218-4014159)   --


    ENSEMBL Gene Tree for NOTCH2 (if available)
    TreeFam Gene Tree for NOTCH2 (if available) 

    Paralogs
    for NOTCH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOTCH2 gene
    NOTCH42  SNED12  NOTCH12  NOTCH32  DLL32  DLL42  JAG22  CRB22  
    JAG12  DNER2  CRB12  DLL12  
    12 SIMAP similar genes for NOTCH2 using alignment to 3 protein entries:     NOTC2_HUMAN (see all proteins):
    NOTCH2NL    NOTCH3    NOTCH1    F9    CUBN    CNTNAP2
    EFEMP1    PROS1    SNED1    NOTCH4    DLK2    EMR2

    NOTCH2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NOTCH2
    PGOHUM00000244876


    Genomic Variants
    for NOTCH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2191 NCBI SNPs in NOTCH2 are shown (see all 2191)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1110336321,2
    		Cpathogenic120510178(-) TGAGTA/GTCTGA 4 Y C mis10--------
    rs1396103741,2
    		--120453754(+) GGATCC/TACTGA 1 -- ds50010--------
    rs1876014041,2
    		--120453822(+) TCTGAA/GTGGCC 1 -- ds50010--------
    rs1922783991,2
    		--120453831(+) CCGGCC/TTGCAC 1 -- ds50010--------
    rs1493059931,2
    		--120453961(+) AATTAC/TGTTAA 1 -- ds50010--------
    rs170244871,2
    		C,F,H,--120454086(+) GACTGA/GTAAGT 1 -- ds500114Minor allele frequency- G:0.06NA NS EA WA CSA 810
    rs1848628371,2
    		--120454180(+) ATTCAC/TGTTCA 1 -- ut310--------
    rs1445548911,2
    		--120454525(+) TTATGA/TTCTAA 1 -- ut310--------
    rs1905520441,2
    		--120454564(+) CTAGGA/CTTTGT 1 -- ut310--------
    rs1484479011,2
    		--120454588(+) AAAAGA/TAAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NOTCH2 (120454176 - 120612276 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for NOTCH2
         9 CNVs: 84503 84502 74666 39005 3309 74667 30405 22949 64724
    Human Gene Mutation Database (HGMD): NOTCH2

    Locus Specific Mutation Databases (LSDB): NOTCH2

    1 SABiosciences Cancer Mutation PCR Assay for NOTCH2:
    Cosmic IdAA Change
    36210p.R2400*
    3 SABiosciences Cancer Mutation PCR Arrays containing NOTCH2:
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOTCH2
    DNA2.0 Custom Variant and Variant Library Synthesis for NOTCH2

    Disorders / Diseases
    for NOTCH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NOTCH2 for disorders           About GeneDecksing

    OMIM gene information: 600275   
    OMIM disorders: 610205  
    UniProtKB/Swiss-Prot: NOTC2_HUMAN, Q04721
  • Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2) [MIM:610205]. Alagille syndrome is an
    • autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association
    with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent
    clinical involvement of the renal and vascular systems
  • Defects in NOTCH2 are the cause of Hajdu-Cheney syndrome (HJCYS) [MIM:102500]. A rare skeletal disorder
    • characterized by the association of facial anomalies, acro-osteolysis, general osteoporosis, insufficient ossification
    of the skull, and periodontal disease (premature loss of permanent teeth). Other features include cleft palate,
    congenital heart defects, polycystic kidneys, orthopedic problems and anomalies of the genitalia, intestines and eyes.
    Note=NOTCH2 mutations associated with Hajdu-Cheney syndrome cluster to the last coding exon of the gene. This suggests
    that the mutant mRNA products may escape nonsense-mediated decay and the resulting truncated NOTCH2 proteins act in a
    gain-of-function manner

    20/60 diseases for NOTCH2 (see all 60):    About MalaCards
    hajdu-cheney syndrome    splenic marginal zone lymphoma    diffuse large b-cell lymphoma    nodular regenerative hyperplasia
    alagille syndrome    b-cell lymphomas    hepatitis    cutaneous malignant melanoma
    lymphocytic leukemia    squamous cell carcinoma    lung squamous cell carcinoma    basal cell carcinoma
    chronic lymphocytic leukemia    cholestasis    osteolysis    renal cell carcinoma
    sjogren's syndrome    diabetes mellitus    multiple myeloma    arteriosclerosis

    3 diseases from the University of Copenhagen DISEASES database for NOTCH2:
    Alagille syndrome     Hajdu-Cheney syndrome     Cancer

    6 Novoseek disease relationships for NOTCH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alagille syndrome 78.1 8 11861489 (3), 19914235 (1), 19551907 (1)
    lymphocytic leukemia chronic b-cell 33.9 1 15621797 (1)
    cholestasis 28.5 1 15307138 (1)
    tumors 13.6 18 17675579 (2), 15520184 (2), 18087195 (2), 19904829 (1) (see all 8)
    cancer 0.41 2 17675579 (1), 19445024 (1)
    breast cancer 0 12 15492845 (5), 18087195 (3), 17675579 (2)

    GeneTests: NOTCH2
    Alagille Syndrome

    Human Genome Epidemiology (HuGE) Navigator: NOTCH2 (44 documents)

    Export disorders for NOTCH2 gene to outside databases

    Publications
    for NOTCH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOTCH2 gene, integrated from 9 sources (see all 213):
    (articles sorted by number of sources associating them with NOTCH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis. (PubMed id 21378989)1, 2 Isidor B....Le Caignec C. (2011)
    2. Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss. (PubMed id 21378985)1, 2 Simpson M.A.... Trembath R.C. (2011)
    3. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. (PubMed id 17573339)1, 2 Coleman M.L....Schofield C.J. (2007)
    4. Structural basis for autoinhibition of Notch. (PubMed id 17401372)1, 2 Gordon W.R.... Blacklow S.C. (2007)
    5. NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. (PubMed id 16773578)1, 2 McDaniell R.... Spinner N.B. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PubMed id 12370315)1, 2 Wu L.... Griffin J.D. (2002)
    8. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. (PubMed id 11101851)1, 2 Wu L....Griffin J.D. (2000)
    9. Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (1999)
    10. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. (PubMed id 9244302)1, 2 Blaumueller C.M.... Artavanis-Tsakonas S. (1997)

    External Searches for NOTCH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOTCH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4853 HGNC: 7882 AceView: NOTCH2 Ensembl:ENSG00000134250 euGenes: HUgn4853
    ECgene: NOTCH2 Kegg: 4853 H-InvDB: NOTCH2

    Other Databases showing NOTCH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOTCH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOTCH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOTCH2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NOTCH2

    Intellectual Property
    for NOTCH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOTCH2 gene:
    Search GeneIP for patents involving NOTCH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NOTCH2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NOTCH2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NOTCH2 (Notch-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for NOTCH2 (Notch-2)  
     Browse OriGene Antibodies   OriGene shRNA RFP for NOTCH2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOTCH2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOTCH2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NOTCH2   OriGene 3'-UTR Clone for NOTCH2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOTCH2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOTCH2   OriGene Custom Protein Services for NOTCH2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOTCH2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOTCH2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOTCH2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOTCH2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOTCH2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOTCH2
     GenScript Custom Purified and Recombinant Proteins Services for NOTCH2 GenScript cDNA clones with any tag delivered in your preferred vector for NOTCH2
     GenScript Custom Assay Services for NOTCH2 GenScript Custom Superior Antibodies Services for NOTCH2
     GenScript Custom overexpressing Cell Line Services for NOTCH2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NOTCH2 
    (Notch 2)

     Regulatory tfbs in NOTCH2 promoter
     Search Chromatin IP Primers for NOTCH2
     RT2 qPCR Primer Assay in human, mouse, rat NOTCH2
     GNC Network for NOTCH2
     SABiosciences PCR Arrays including human, mouse, rat NOTCH2
     Search Tocris compounds for NOTCH2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NOTCH2 antibodies
     NOTCH2 proteins
     Antibodies for NOTCH2
     See all of Abcam's Antibodies, Kits and Proteins for NOTCH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NOTCH2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NOTCH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH2
     SwitchGear 3'UTR luciferase reporter plasmids for NOTCH2
     SwitchGear Promoter luciferase reporter plasmids for NOTCH2
     ThermoFisher Antibodies for NOTCH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOTCH2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NOTCH2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4