Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NOTCH1 Gene

protein-coding   GIFtS: 70
GCID: GC09M139388

Notch 1

(Previous names: Notch (Drosophila) homolog 1 (translocation-associated),...)
(Previous symbol: TAN1)
  See NOTCH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Notch 11 2 3     Notch Homolog 1, Translocation-Associated (Drosophila)1
TAN11 2 3 5     Neurogenic Locus Notch Homolog Protein 12
Translocation-Associated Notch Protein TAN-12 3     Notch Homolog 1, Translocation-Associated2
hN12 3     EC 2.1.2.118
Notch (Drosophila) Homolog 1 (Translocation-Associated)1     EC 3.4.21.688

External Ids:    HGNC: 78811   Entrez Gene: 48512   Ensembl: ENSG000001484007   OMIM: 1901985   UniProtKB: P465313   

Export aliases for NOTCH1 gene to outside databases

Previous GC identifers: GC09M130458 GC09M131078 GC09M132829 GC09M134746 GC09M136664 GC09M138508 GC09M108848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOTCH1 Gene:
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share
structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like
(EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members
play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling
network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between
physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate)
establishes an intercellular signaling pathway that plays a key role in development. Homologues of the
notch-ligands have also been identified in human, but precise interactions between these ligands and the human
notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on
the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play
multiple roles during development. (provided by RefSeq, Jul 2008)

GeneCards Summary for NOTCH1 Gene:
NOTCH1 (notch 1) is a protein-coding gene. Diseases associated with NOTCH1 include invasive bladder transitional cell carcinoma, and nerve compression syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: NOTC1_HUMAN, P46531
Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively
regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of
both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection
within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in
the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role
in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be
involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering
HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the
subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the
balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)

Gene Wiki entry for NOTCH1 (Notch-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOTCH1 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NOTCH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOTCH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

NOTCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOTCH1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M139388:  view genomic region     (about GC identifiers)

Start:
139,388,896 bp from pter      End:
139,440,314 bp from pter
Size:
51,419 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOTC1_HUMAN, P46531 (See protein sequence)
Recommended Name: Neurogenic locus notch homolog protein 1 precursor  
Size: 2555 amino acids; 272505 Da
Subunit: Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by
disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3
which act as transcriptional coactivators for NOTCH1. Notch 1 intracellular domain interacts with SNW1; the
interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation
complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which
promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN
negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation.
Interacts (via NICD) with SNAI1 (via zinc fingers); the interaction induces SNAI1 degradation via MDM2-mediated
ubiquitination and inhibits SNAI1-induced cell invasion. Interacts (via NICD) with MDM2A. Interacts (via NICD)
with BCL6; the interaction decreases MAML1 recruitment by NOTCH1 NICD on target genes DNA and inhibits NOTCH1
transcractivation activity. Interacts with THBS4 (By similarity)
Selected PDB 3D structures from and Proteopedia for NOTCH1 (see all 12):
1PB5 (3D)        1TOZ (3D)        1YYH (3D)        2F8X (3D)        2F8Y (3D)        2HE0 (3D)    
Secondary accessions: Q59ED8 Q5SXM3

Explore the universe of human proteins at neXtProt for NOTCH1: NX_P46531

Explore proteomics data for NOTCH1 at MOPED

Post-translational modifications: 

  • Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like
    convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible
    form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding,
    it is cleaved by ADAM17 to yield a membrane-associated intermediate fragment called notch extracellular
    truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase
    to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity)1
  • Phosphorylated (By similarity)1
  • O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose. O-linked glycosylation
    by GALNT11 is involved in determination of left/right symmetry: glycosylation promotes activation of NOTCH1,
    possibly by promoting cleavage by ADAM17, modulating the balance between motile and immotile (sensory) cilia at
    the left-right organiser (LRO)1
  • Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. Monoubiquitination at Lys-1759 is
    required for activation by gamma-secretase cleavage, it promotes interaction with AAK1, which stabilizes it.
    Deubiquitination by EIF3F is necessary for nuclear import of activated Notch1
  • Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces
    affinity for HI1AN and may thus indirectly modulate negative regulation of NICD (By similarity)1
  • Ubiquitination2 at Lys1759
  • Glycosylation2 at Asn41, Ser65, Thr73, Thr116, Ser146, Thr194, Thr232, Ser341, Ser378, Ser458,
                                 Thr466, Ser496, Ser534, Ser609, Ser647, Ser722, Ser759, Thr767, Ser797, Thr805 (see all 35)
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NOTCH1 (P46531)
     CFNGGTC  INTLGSF 


    See NOTCH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060087.3  
    ENSEMBL proteins: 
     ENSP00000277541  
    Reactome Protein details: P46531

    NOTCH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NOTCH1 (Notch-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NOTCH1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NOTCH1
    GenScript Custom Purified and Recombinant Proteins Services for NOTCH1
    Novus Biologicals NOTCH1 Proteins
    Novus Biologicals NOTCH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for NOTCH1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NOTCH1 

    NOTCH1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NOTCH1
    R&D Systems Antibodies for NOTCH1 (Notch-1)
    Cell Signaling Technology (CST) Antibodies for NOTCH1  (Notch 1)
    OriGene Antibodies for NOTCH1
    OriGene Custom Antibody Services for NOTCH1
    Novus Biologicals NOTCH1 Antibodies
    Abcam antibodies for NOTCH1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NOTCH1
    LSBio Antibodies in human, mouse, rat for NOTCH1

    NOTCH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOTCH1
    R&D Systems ELISAs for NOTCH1 (Notch-1)         (see all)
    GenScript Custom Assay Services for NOTCH1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for NOTCH1 (Notch 1)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NOTCH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 14):
     IPR010660 Notch_NOD_dom
     IPR022362 Notch_1
     IPR024600 DUF3454_notch
     IPR001881 EGF-like_Ca-bd_dom
     IPR008297 Notch

    Graphical View of Domain Structure for InterPro Entry P46531

    ProtoNet protein and cluster: P46531

    4 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000800 LIN-12/notch repeat (LNR) signature
    IPB001881 EGF-like calcium-binding
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: NOTC1_HUMAN, P46531
    Similarity: Belongs to the NOTCH family
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 36 EGF-like domains
    Similarity: Contains 3 LNR (Lin/Notch) repeats


    Find genes that share domains with NOTCH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOTC1_HUMAN, P46531
    Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate
    determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a
    transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects
    the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively
    regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of
    both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection
    within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in
    the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role
    in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be
    involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering
    HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the
    subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the
    balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)

         Genatlas biochemistry entry for NOTCH1:
    Drosophila Notch homolog 1,mediating cell-cell interactions that specify cell fate during development,undergoing a
    first proteolytic cleavage by furin (PACE1) in the Golgi during trafficking of Notch to the cell
    surface,undergoing further cleavage by gamma secretase (see PSEN1) releasing an intracellular domain (NICD) which
    translocates to the nucleus and modulates transcription of target genes,involved in acute lymphocytic leukemia
    with translocation t(7;9)(q34;q34.3),expressed in CD34+ hematopoietic cells (see TAN1) and in the developing
    cochlear duct,inducing delay of hematopoietic differentiation and alteration of cell cycle kinetics

         Enzyme Numbers (IUBMB): EC 2.1.2.112 EC 3.4.21.682

         Summary: 
    During embryonic development, NOTCH1 as signaling molecule is secreted from the following cells:
          selected tissues (see all 4)      
    Epidermis: Intermediate Keratinocytes (Embryonic Epidermis), Spinous Keratinocytes (Stratified Epidermis)
    Cartilage: Intervertebral Disc Nucleus Pulposus Cells (Nucleus Pulposus)

    It affects the following cells:
          selected tissues (see all 8)      fully expand
    Epidermis: Granular Keratinocytes (Stratified Epidermis), Intermediate Keratinocytes (Embryonic Epidermis)      fully expand to see all 3 cells
    Primitive Streak: Hemangioblasts (Posterior Primitive Streak), Notochord Cells (Posterior Primitive Streak)      fully expand to see all 2 cells

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding ISS--
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0003682chromatin binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004857enzyme inhibitor activity ISS--
         
    Find genes that share ontologies with NOTCH1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NOTCH1:
     Synthetic lethal with cisplati 

         Selected MGI mutant phenotypes (inferred from 15 alleles(MGI details for Notch1) (see all 23):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with NOTCH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NOTCH1: Notch1tm1Con Notch1tm1Pst Notch1tm1Grid Notch1tm2.1Pst Notch1tm2Agt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOTCH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOTCH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOTCH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOTCH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOTCH1:
    hsa-mir-24-3p (MIRT001773), hsa-mir-30a-5p (MIRT002876), hsa-mir-181a-5p (MIRT035538), hsa-mir-34b-3p (MIRT006458), hsa-mir-10b-5p (MIRT006924), hsa-mir-27b-3p (MIRT001768), hsa-mir-326 (MIRT004424), hsa-mir-34c-5p (MIRT006459), hsa-mir-34a-5p (MIRT002875), hsa-mir-23b-3p (MIRT001775), hsa-mir-449a (MIRT006446), hsa-mir-129-5p (MIRT005412), hsa-mir-144-3p (MIRT005869)

    Block miRNA regulation of human, mouse, rat NOTCH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOTCH1 (see all 48):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-548k hsa-miR-25 hsa-miR-139-5p hsa-miR-30d hsa-miR-449a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidNOTCH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOTCH1
    Predesigned siRNA for gene silencing in human, mouse, rat NOTCH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOTCH1

    Clone
    Products:
         
    OriGene clones in human, mouse for NOTCH1 (see all 5)
    OriGene ORF clones in mouse, rat for NOTCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOTCH1 (NM_017617)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTCH1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NOTCH1
    Addgene plasmids for NOTCH1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOTCH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOTCH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12011) for NOTCH1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOTC1_HUMAN, P46531: Cell membrane; Single-pass type I membrane protein (By similarity)
    NOTC1_HUMAN, P46531: Notch 1 intracellular domain: Nucleus (By similarity). Note=Following proteolytical
    processing NICD is translocated to the nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    endoplasmic reticulum4
    extracellular4
    golgi apparatus4
    nucleus4
    cytoskeleton2
    endosome2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0002193MAML1-RBP-Jkappa- ICN1 complex IDA16510869
    GO:0005576extracellular region TAS--
    GO:0005634nucleus TAS10713164
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with NOTCH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NOTCH1 About   (see all 29)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    Notch Signaling0.30
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Notch-HLH transcription pathway0.00
    Pre-NOTCH Transcription and Translation0.62
    Pre-NOTCH Processing in the Endoplasmic Reticulum0.00
    Pre-NOTCH Processing in Golgi0.00
    4Signaling by NOTCH2
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant0.00
    5Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells0.00


    Find genes that share SuperPaths with NOTCH1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOTCH1
        Notch Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOTCH1
        Notch Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Epithelial Adherens Junctions
    Pancreatic Adenocarcinoma

    3 Cell Signaling Technology (CST) Pathways for NOTCH1
        Wnt / Hedgehog / Notch
    Angiogenesis
    Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for NOTCH1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    Selected BioSystems Pathways for NOTCH1 (see all 9)
        Heart Development
    Notch Signaling Pathway
    Gastric cancer network 1
    Cardiac Progenitor Differentiation
    Neural Crest Differentiation


    Selected Reactome Pathways for NOTCH1 (see all 12)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
    Notch-HLH transcription pathway
    Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells


    5 Kegg Pathways  (Kegg details for NOTCH1):
        Dorso-ventral axis formation
    Notch signaling pathway
    Thyroid hormone signaling pathway
    Prion diseases
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH1 (see all 16): 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Lymphoma in human mouse rat
              Notch Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOTCH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOTCH1 (P465311, 2, 3 ENSP000002775414) via UniProtKB, MINT, STRING, and/or I2D (see all 311)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB1P198381, 2, 3, ENSP000002265744EBI-636374,EBI-300010 MINT-2738217 I2D: score=3 STRING: ENSP00000226574
    SNW1Q135731, 3, ENSP000002615314EBI-636374,EBI-632715 I2D: score=4 STRING: ENSP00000261531
    XRCC6P129562, 3, ENSP000003522574MINT-64468 I2D: score=4 STRING: ENSP00000352257
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2861240 I2D: score=3 STRING: ENSP00000344782
    MAML1Q925852, 3, ENSP000002925994MINT-8177109 I2D: score=3 STRING: ENSP00000292599
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 136):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001701in utero embryonic development IEA--
    GO:0001708cell fate specification IEA--
    GO:0001837epithelial to mesenchymal transition ISS--
    GO:0001889liver development IEA--

    Find genes that share ontologies with NOTCH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOTCH1 (NOTC1)

    1 HMDB Compound for NOTCH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for NOTCH1 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 37.9 1 16510599 (1)
    vegf 30 30 18182722 (8), 18056465 (3), 19923082 (3), 16510599 (3) (see all 10)
    asparagine 17.1 1 19245366 (1)
    rapamycin 16.2 3 16651424 (1), 20194733 (1)
    glycogen 9.93 4 10541869 (1), 17234779 (1), 16941152 (1), 19030935 (1)
    threonine 5.51 4 17901244 (1), 19635999 (1), 16282337 (1)
    nitric oxide 5.13 2 15887117 (1), 20147635 (1)
    dexamethasone 4.92 1 16914556 (1)
    oxygen 4.4 5 17179479 (1), 17804701 (1), 19143764 (1), 18924608 (1)
    lipid 2.38 9 18593473 (1), 18991739 (1), 19405120 (1), 19948478 (1) (see all 6)



    Find genes that share compounds with NOTCH1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NOTCH1 gene: 
    NM_017617.3  

    Unigene Cluster for NOTCH1:

    Notch 1
    Hs.495473  [show with all ESTs]
    Unigene Representative Sequence: NM_017617
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277541(uc004cia.1 uc004chz.3) ENST00000494783 ENST00000491649

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOTCH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOTCH1 (see all 48):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-548k hsa-miR-25 hsa-miR-139-5p hsa-miR-30d hsa-miR-449a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidNOTCH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOTCH1
    Predesigned siRNA for gene silencing in human, mouse, rat NOTCH1
    Clone
    Products:
         
    OriGene clones in human, mouse for NOTCH1 (see all 5)
    OriGene ORF clones in mouse, rat for NOTCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOTCH1 (NM_017617)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOTCH1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NOTCH1
    Addgene plasmids for NOTCH1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NOTCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOTCH1
      QuantiTect SYBR Green Assays in human, mouse, rat NOTCH1
      QuantiFast Probe-based Assays in human, mouse, rat NOTCH1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12011) for NOTCH1 

    Additional mRNA sequence: 

    AB209873.1 AF308602.1 AK000012.1 BC013208.1 BC039147.1 BC046127.1 BC049843.1 BC063597.1 
    CR457221.1 M73980.1 

    3 DOTS entries:

    DT.116684  DT.101967676  DT.92324288 

    Selected AceView cDNA sequences (see all 207):

    BC049843 AA460357 BX439805 AI244768 BM709403 AI493630 BU633949 BX281173 
    BI712771 AW505499 Z44046 AI364702 F04067 AI598175 BU733339 BM549261 
    BM680772 AA401031 BQ636034 BP381398 BF060687 AW503914 AA278939 BC039147 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NOTCH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAACTGTA
    NOTCH1 Expression
    About this image


    NOTCH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Epithelial Cells
             Adult Corneal Basal Epithelial Cells Corneal Epithelium
     
     Hair
             Fetal Matrix Cells Hair Follicle
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Early Retinal Progenitor Cells Retinal Neuroblastic Layer
             Lens
     
     Epidermis (Integumentary System)    fully expand to see all 4 entries
             Basal Keratinocytes Embryonic Epidermis
     
     Tooth (Integumentary System)    fully expand to see all 7 entries
             Inner Enamel Epithelial Cells Dental Enamel
             Stem cells from human exfoliated deciduous teeth (family)
    NOTCH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOTCH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495473

    UniProtKB/Swiss-Prot: NOTC1_HUMAN, P46531
    Tissue specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult
    tissues where it is found mainly in lymphoid tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOTCH1 (see all 16): 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Stem Cell Signaling in human mouse rat
              Lymphoma in human mouse rat
              Notch Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOTCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOTCH1
    QuantiTect SYBR Green Assays in human, mouse, rat NOTCH1
    QuantiFast Probe-based Assays in human, mouse, rat NOTCH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NOTCH1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Notch11 , 5 Notch gene homolog 1 (Drosophila)5
    notch 11
    85.98(n)1
    91.64(a)1
      2 (18.91 cM)5
    181281  NM_008714.31  NP_032740.31 
     264579035 
    chicken
    (Gallus gallus)
    Aves NOTCH11 notch 1 79.79(n)
    81.23(a)
      395655  XM_415420.4  XP_415420.4 
    lizard
    (Anolis carolinensis)
    Reptilia NOTCH16
    notch 1
    73(a)
    1 ↔ 1
    AAWZ02036232(2523-29619)
    African clawed frog
    (Xenopus laevis)
    Amphibia notch1-A-prov2 Notch protein 76.65(n)    M33874.1 
    zebrafish
    (Danio rerio)
    Actinopterygii notch1a2 notch homolog 1a 76.68(n)   30718  NM_131441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta N1 Notch 55.85(n)
    49.64(a)
      31293  NM_001258581.1  NP_001245510.1 


    ENSEMBL Gene Tree for NOTCH1 (if available)
    TreeFam Gene Tree for NOTCH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NOTCH1 gene
    DLK22  SNED12  NOTCH42  DLL32  NOTCH32  JAG22  CRB22  DLL42  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    9 SIMAP similar genes for NOTCH1 using alignment to 8 protein entries:     NOTC1_HUMAN (see all proteins):
    NOTCH2    F9    NOTCH3    CNTNAP2    NOTCH2NL    DLK1
    DKFZp434N181    DLK2    NOTCH4

    Find genes that share paralogs with NOTCH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NOTCH1 (see all 2267)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs413097641,2
    Cpathogenic1139439260(-) CGCAGC/TGACAA 2 R * stg12Minor allele frequency- T:0.00NA 4
    rs29905831,2
    C,A--108901673(+) AGCCCC/TTCCCA 1 -- spa110Minor allele frequency- T:0.32NA CSA WA EA 371
    rs1152296561,2
    F--108901734(+) ACCCTG/CTGCCA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1923388451,2
    --108901882(+) CCGGCG/TCCCCT 1 -- int10--------
    rs1830986251,2
    --108901944(+) GGGACC/GTAGGA 1 -- int10--------
    rs1879213011,2
    --108901956(+) TGTGGA/GGGCCT 1 -- int10--------
    rs1131209501,2
    C,F--108901983(+) AAACCC/GCAGAG 1 -- int12Minor allele frequency- G:0.03CSA WA 119
    rs1433356551,2
    --108902119(+) CGCCCC/TTGTAG 1 -- int10--------
    rs765656701,2
    F--108902166(+) GAATCT/CGGCCT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1392003061,2
    --108902226(+) GAGGCA/GCCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOTCH1 (139388896 - 139440314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NOTCH1 (see all 49):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739363CNV Deletion23290073
    esv4392CNV Deletion18987735
    esv2739365CNV Deletion23290073
    esv2677489CNV Deletion23128226
    esv2739364CNV Deletion23290073
    esv2062576CNV Deletion18987734
    dgv1339e201CNV Deletion23290073
    esv2739366CNV Deletion23290073
    nsv6768CNV Insertion18451855
    nsv509334CNV Insertion20534489

    Human Gene Mutation Database (HGMD): NOTCH1
    Selected Site Specific Mutation Identification with PCR Assays for NOTCH1 (see all 11):
    Cosmic IdAA Change
    12776p.Q2460*
    12772p.L1575P
    13047p.V1579del
    13048p.L1679P
    13046p.L1586P
    5 Site Specific Cancer Mutation PCR Panels containing NOTCH1:
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lymphoid Neoplasms
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    SeqTarget long-range PCR primers for resequencing NOTCH1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOTCH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 190198   
    OMIM disorders: 109730  
    UniProtKB/Swiss-Prot: NOTC1_HUMAN, P46531
  • Aortic valve disease 1 (AOVD1) [MIM:109730]: A common defect in the aortic valve in which two rather than
    three leaflets are present. It is often associated with aortic valve calcification, stenosis and insufficiency.
    In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in
    hypoplastic left heart syndrome. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for NOTCH1 (see all 25):    
    About MalaCards
    invasive bladder transitional cell carcinoma    nerve compression syndrome    left ventricular outflow tract obstruction    familial bicuspid aortic valve
    bladder transitional cell carcinoma    aortic valve disease    cutaneous neuroendocrine carcinoma    superficial basal cell carcinoma
    esophagus squamous cell carcinoma    cadasil    acute t cell leukemia    transitional cell carcinoma
    plasmablastic lymphoma    acute biphenotypic leukemia    neuroendocrine carcinoma    hypoplastic left heart syndrome
    alagille syndrome    spondylocostal dysostosis    nodular regenerative hyperplasia    ossifying fibroma

    16 diseases from the University of Copenhagen DISEASES database for NOTCH1:
    Alagille syndrome     Alzheimer's disease     Leukemia     Cadasil
    Congenital heart defect     Spondylocostal dysostosis     Lymphoma     Heart disease
    Osteochondritis dissecans     Breast cancer     Hypertension     Nerve compression syndrome
    Osteoarthritis     Otosclerosis     Malignant glioma     Cerebrovascular accident

    Find genes that share disorders with NOTCH1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NOTCH1 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 90.7 271 15548998 (6), 19245433 (5), 16707600 (5), 18414037 (5) (see all 80)
    leukemogenesis 61.7 17 20194733 (3), 18497996 (2), 15058751 (1), 15694671 (1) (see all 9)
    leukemia t-cell 60.1 13 16954387 (3), 17483057 (2), 19349467 (1), 15231576 (1) (see all 6)
    leukaemia lymphocytic 57.2 15 17008890 (1), 8642337 (1), 11964309 (1), 19091404 (1) (see all 11)
    alagille syndrome 51.3 1 10075489 (1)
    tumors 50.9 183 17874453 (5), 19479935 (5), 11964309 (4), 17344417 (4) (see all 84)
    gastrointestinal carcinoid tumor 50.1 1 16160079 (1)
    leukemia 49.4 56 19794083 (6), 18677410 (5), 18991739 (4), 17008890 (3) (see all 22)
    cancer 41.8 49 17534448 (5), 18184405 (4), 19923082 (3), 19151708 (2) (see all 22)
    lymphoma lymphoblastic 36 1 18663146 (1)

    Genetic Association Database (GAD): NOTCH1
    Human Genome Epidemiology (HuGE) Navigator: NOTCH1 (19 documents)
    Tumor Gene Database (TGDB): NOTCH1

    Export disorders for NOTCH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NOTCH1 gene, integrated from 10 sources (see all 1015):
    (articles sorted by number of sources associating them with NOTCH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. (PubMed id 1831692)1, 2, 3 Ellisen L.W.... Sklar J. (Cell 1991)
    2. Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. (PubMed id 19794083)1, 4, 9 Baldus C.D....Hofmann W.K. (Haematologica 2009)
    3. FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. (PubMed id 19245433)1, 4, 9 Park M.J....Hayashi Y. (Br. J. Haematol. 2009)
    4. The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. (PubMed id 19340001)1, 4, 9 Larson Gedman A....Matherly L.H. (Leukemia 2009)
    5. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. (PubMed id 16707600)1, 4, 9 Zhu Y.M....Chen S.J. (Clin. Cancer Res. 2006)
    6. NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study. (PubMed id 19109228)1, 4, 9 Asnafi V....Macintyre E. (Blood 2009)
    7. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4, 9 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
    8. Mutations in NOTCH1 cause aortic valve disease. (PubMed id 16025100)1, 2, 9 Garg V.... Srivastava D. (Nature 2005)
    9. Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. (PubMed id 21147854)1, 2 Mo J.S....Park H.S. (J. Cell Sci. 2011)
    10. Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. (PubMed id 22128911)1, 2 Lim S.O....Jung G. (BMC Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4851 HGNC: 7881 AceView: NOTCH1 Ensembl:ENSG00000148400 euGenes: HUgn4851
    ECgene: NOTCH1 Kegg: 4851 H-InvDB: NOTCH1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NOTCH1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOTCH1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NOTCH1 gene:
    Search GeneIP for patents involving NOTCH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of NOTCH1
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for NOTCH1 (Notch-1)   Browse Cell Culture Products  
     ELISAs for NOTCH1 (Notch-1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NOTCH1 (Notch-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for NOTCH1 (Notch-1)  
     OriGene Antibodies for NOTCH1   OriGene RNAi products in human, mouse, rat for NOTCH1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NOTCH1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NOTCH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOTCH1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NOTCH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOTCH1   OriGene Custom Protein Services for NOTCH1  

     
     
     Block miRNA regulation of human, mouse, rat NOTCH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NOTCH1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOTCH1 Predesigned siRNA for gene silencing in human, mouse, rat NOTCH1
     QuantiFast Probe-based Assays in human, mouse, rat NOTCH1 QuantiTect SYBR Green Assays in human, mouse, rat NOTCH1
     PCR Arrays including human, mouse, rat NOTCH1 Search Chromatin IP Primers for NOTCH1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOTCH1  GeneGlobe Interaction Network for NOTCH1
     Regulatory tfbs in NOTCH1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NOTCH1 GenScript cDNA clones with any tag delivered in your preferred vector for NOTCH1
     GenScript Custom Assay Services for NOTCH1 GenScript Custom overexpressing Cell Line Services for NOTCH1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NOTCH1 
    (Notch 1)

     Search Tocris compounds for NOTCH1 (NOTC1)
     Browse Sino Biological Proteins
     Cell Lysates for NOTCH1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NOTCH1 antibodies
     NOTCH1 proteins
     NOTCH1 lysates
     Antibodies for NOTCH1
     See all of Abcam's Antibodies, Kits and Proteins for NOTCH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NOTCH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOTCH1
     SwitchGear 3'UTR luciferase reporter plasmids for NOTCH1
     Browse SwitchGear Promoter luciferase reporter plasmids for NOTCH1
     ThermoFisher Antibody for NOTCH1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NOTCH1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOTCH1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOTCH1
     LSBio Antibodies in human, mouse, rat for NOTCH1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for NOTCH1
      Search eBioscience for proteins for NOTCH1
      Search eBioscience for elisas for NOTCH1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOTCH1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4