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Aliases for NOSTRIN Gene

Aliases for NOSTRIN Gene

  • Nitric Oxide Synthase Trafficking 2 3 5
  • Nitric Oxide Synthase Trafficker 2 3 4
  • Nitric Oxide Synthase Traffic Inducer 3 4
  • ENOS-Trafficking Inducer 3 4
  • BM247 Homolog 3 4
  • Endothelial Nitric Oxide Synthase Traffic Inducer 3
  • Ortholog Of Mouse Disabled 2 Interacting Proein 2 3
  • ENOS Traffic Inducer 3
  • DaIP2 3

External Ids for NOSTRIN Gene

Previous GeneCards Identifiers for NOSTRIN Gene

  • GC02P168186
  • GC02P169607
  • GC02P169861
  • GC02P169469
  • GC02P169367
  • GC02P161522
  • GC02P169643

Summaries for NOSTRIN Gene

Entrez Gene Summary for NOSTRIN Gene

  • Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

GeneCards Summary for NOSTRIN Gene

NOSTRIN (Nitric Oxide Synthase Trafficking) is a Protein Coding gene. Diseases associated with NOSTRIN include Pre-Eclampsia and Eclampsia. Among its related pathways are eNOS activation and regulation and Metabolism.

UniProtKB/Swiss-Prot for NOSTRIN Gene

  • Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOSTRIN Gene

Genomics for NOSTRIN Gene

Regulatory Elements for NOSTRIN Gene

Enhancers for NOSTRIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOSTRIN on UCSC Golden Path with GeneCards custom track

Genomic Location for NOSTRIN Gene

168,786,539 bp from pter
168,865,514 bp from pter
78,976 bases
Plus strand

Genomic View for NOSTRIN Gene

Genes around NOSTRIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOSTRIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOSTRIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOSTRIN Gene

Proteins for NOSTRIN Gene

  • Protein details for NOSTRIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K2I9
    • B3KSF5
    • E7EPT9
    • Q27HG3
    • Q53S62
    • Q96CJ9

    Protein attributes for NOSTRIN Gene

    506 amino acids
    Molecular mass:
    57660 Da
    Quaternary structure:
    • Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.

    Three dimensional structures from OCA and Proteopedia for NOSTRIN Gene

    Alternative splice isoforms for NOSTRIN Gene


neXtProt entry for NOSTRIN Gene

Proteomics data for NOSTRIN Gene at MOPED

Post-translational modifications for NOSTRIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOSTRIN Gene

Domains & Families for NOSTRIN Gene

Protein Domains for NOSTRIN Gene

Suggested Antigen Peptide Sequences for NOSTRIN Gene

Graphical View of Domain Structure for InterPro Entry



  • The SH3 domain mediates interaction with NOS3, DNM2 and WASL.
  • The SH3 domain mediates interaction with NOS3, DNM2 and WASL.
  • The F-BAR domain is necessary for membrane targeting.
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with NOSTRIN: view

No data available for Gene Families for NOSTRIN Gene

Function for NOSTRIN Gene

Molecular function for NOSTRIN Gene

UniProtKB/Swiss-Prot Function:
Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
genes like me logo Genes that share phenotypes with NOSTRIN: view

Animal Models for NOSTRIN Gene

MGI Knock Outs for NOSTRIN:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NOSTRIN Gene

Localization for NOSTRIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOSTRIN Gene

Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).
Isoform 3: Nucleus.

Subcellular locations from

Jensen Localization Image for NOSTRIN Gene COMPARTMENTS Subcellular localization image for NOSTRIN gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for NOSTRIN Gene

Pathways & Interactions for NOSTRIN Gene

genes like me logo Genes that share pathways with NOSTRIN: view

Pathways by source for NOSTRIN Gene

1 Qiagen pathway for NOSTRIN Gene

Gene Ontology (GO) - Biological Process for NOSTRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046209 nitric oxide metabolic process TAS --
genes like me logo Genes that share ontologies with NOSTRIN: view

No data available for SIGNOR curated interactions for NOSTRIN Gene

Drugs & Compounds for NOSTRIN Gene

(1) Drugs for NOSTRIN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NOSTRIN: view

Transcripts for NOSTRIN Gene

Unigene Clusters for NOSTRIN Gene

Nitric oxide synthase trafficker:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOSTRIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: - - -
SP2: -
SP3: -

Relevant External Links for NOSTRIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOSTRIN Gene

mRNA expression in normal human tissues for NOSTRIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOSTRIN Gene

This gene is overexpressed in Spleen (14.9), Lung (9.1), Placenta (8.8), Urine (7.0), and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOSTRIN Gene

SOURCE GeneReport for Unigene cluster for NOSTRIN Gene Hs.189780

mRNA Expression by UniProt/SwissProt for NOSTRIN Gene

Tissue specificity: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
genes like me logo Genes that share expression patterns with NOSTRIN: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for NOSTRIN Gene

Orthologs for NOSTRIN Gene

This gene was present in the common ancestor of animals.

Orthologs for NOSTRIN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOSTRIN 35
  • 86.27 (n)
  • 81.98 (a)
  • 82 (a)
(Canis familiaris)
Mammalia NOSTRIN 35
  • 85.31 (n)
  • 82.02 (a)
  • 76 (a)
(Mus musculus)
Mammalia Nostrin 35
  • 84.78 (n)
  • 82.61 (a)
Nostrin 16
Nostrin 36
  • 83 (a)
(Pan troglodytes)
Mammalia NOSTRIN 35
  • 99.54 (n)
  • 99.8 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Nostrin 35
  • 83.6 (n)
  • 82.2 (a)
(Monodelphis domestica)
Mammalia NOSTRIN 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NOSTRIN 36
  • 66 (a)
(Anolis carolinensis)
Reptilia NOSTRIN 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nostrin 35
  • 64.04 (n)
  • 58.5 (a)
(Danio rerio)
Actinopterygii nostrin 35
  • 56.45 (n)
  • 47.18 (a)
nostrin 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010676 35
  • 44.2 (n)
  • 31.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42388 35
  • 43.39 (n)
  • 33.73 (a)
CG42388 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea C36E8.4 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for NOSTRIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOSTRIN Gene

Gene Tree for NOSTRIN (if available)
Gene Tree for NOSTRIN (if available)

Paralogs for NOSTRIN Gene

genes like me logo Genes that share paralogs with NOSTRIN: view

No data available for Paralogs for NOSTRIN Gene

Variants for NOSTRIN Gene

Sequence variations from dbSNP and Humsavar for NOSTRIN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_032569 -
rs475808 -- 168,819,056(+) AAATG(C/G)AAAAG intron-variant
rs482435 -- 168,819,535(+) AAGCC(A/G)TTCAG intron-variant
rs486153 -- 168,826,456(-) GGAGG(A/G)AGGGA intron-variant
rs486838 -- 168,826,446(-) AGGGA(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOSTRIN Gene

Variant ID Type Subtype PubMed ID
nsv875381 CNV Loss 21882294
nsv516627 CNV Loss 19592680
nsv3023 CNV Insertion 18451855
esv999271 CNV Insertion 20482838
nsv227 CNV Insertion 15895083

Variation tolerance for NOSTRIN Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOSTRIN Gene

Disorders for NOSTRIN Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOSTRIN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • preeclampsia
  • eclampsia in puerperium
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NOSTRIN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NOSTRIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOSTRIN Gene

Publications for NOSTRIN Gene

  1. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. (PMID: 12446846) Zimmermann K. … Oess S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23 67
  2. NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. (PMID: 18980613) Wiesenthal A. … Siehoff-Icking A. (Traffic 2009) 3 23
  3. Endothelial nitric oxide synthase traffic inducer in the umbilical vessels of the patients with pre-eclampsia. (PMID: 19399414) Xiang W. … Xu X. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009) 3 23
  4. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. (PMID: 16807357) Schilling K. … Icking A. (Mol. Biol. Cell 2006) 3 23
  5. Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN. (PMID: 15596140) Choi Y.J. … Park S.S. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for NOSTRIN Gene

Sources for NOSTRIN Gene