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Aliases for NOSTRIN Gene

Aliases for NOSTRIN Gene

  • Nitric Oxide Synthase Trafficking 2 3
  • Nitric Oxide Synthase Trafficker 2 3 4
  • Nitric Oxide Synthase Traffic Inducer 3 4
  • ENOS-Trafficking Inducer 3 4
  • BM247 Homolog 3 4
  • Endothelial Nitric Oxide Synthase Traffic Inducer 3
  • Ortholog Of Mouse Disabled 2 Interacting Proein 2 3
  • ENOS Traffic Inducer 3
  • Nostrin 3
  • DaIP2 3

External Ids for NOSTRIN Gene

Previous GeneCards Identifiers for NOSTRIN Gene

  • GC02P168186
  • GC02P169607
  • GC02P169861
  • GC02P169469
  • GC02P169367
  • GC02P161522
  • GC02P169643

Summaries for NOSTRIN Gene

Entrez Gene Summary for NOSTRIN Gene

  • Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]

GeneCards Summary for NOSTRIN Gene

NOSTRIN (Nitric Oxide Synthase Trafficking) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Metabolism.

UniProtKB/Swiss-Prot for NOSTRIN Gene

  • Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOSTRIN Gene

Genomics for NOSTRIN Gene

Regulatory Elements for NOSTRIN Gene

Genomic Location for NOSTRIN Gene

Start:
168,786,539 bp from pter
End:
168,865,514 bp from pter
Size:
78,976 bases
Orientation:
Plus strand

Genomic View for NOSTRIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOSTRIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOSTRIN Gene

Proteins for NOSTRIN Gene

  • Protein details for NOSTRIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVI9-NOSTN_HUMAN
    Recommended name:
    Nostrin
    Protein Accession:
    Q8IVI9
    Secondary Accessions:
    • A8K2I9
    • B3KSF5
    • E7EPT9
    • Q27HG3
    • Q53S62
    • Q96CJ9

    Protein attributes for NOSTRIN Gene

    Size:
    506 amino acids
    Molecular mass:
    57660 Da
    Quaternary structure:
    • Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.

    Three dimensional structures from OCA and Proteopedia for NOSTRIN Gene

    Alternative splice isoforms for NOSTRIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOSTRIN Gene

Proteomics data for NOSTRIN Gene at MOPED

Post-translational modifications for NOSTRIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NOSTRIN Gene

Domains for NOSTRIN Gene

Suggested Antigen Peptide Sequences for NOSTRIN Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVI9

UniProtKB/Swiss-Prot:

NOSTN_HUMAN :
  • Q8IVI9
Domain:
  • The SH3 domain mediates interaction with NOS3, DNM2 and WASL
  • The F-BAR domain is necessary for membrane targeting
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with NOSTRIN: view

No data available for Gene Families for NOSTRIN Gene

Function for NOSTRIN Gene

Molecular function for NOSTRIN Gene

UniProtKB/Swiss-Prot Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.

Gene Ontology (GO) - Molecular Function for NOSTRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 12446846
genes like me logo Genes that share ontologies with NOSTRIN: view

Phenotypes for NOSTRIN Gene

genes like me logo Genes that share phenotypes with NOSTRIN: view

Animal Models for NOSTRIN Gene

MGI Knock Outs for NOSTRIN:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NOSTRIN Gene

Localization for NOSTRIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOSTRIN Gene

Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOSTRIN Gene COMPARTMENTS Subcellular localization image for NOSTRIN gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for NOSTRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with NOSTRIN: view

Pathways for NOSTRIN Gene

genes like me logo Genes that share pathways with NOSTRIN: view

Pathways by source for NOSTRIN Gene

1 Qiagen pathway for NOSTRIN Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for NOSTRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0046209 nitric oxide metabolic process TAS --
genes like me logo Genes that share ontologies with NOSTRIN: view

Compounds for NOSTRIN Gene

(1) Novoseek inferred chemical compound relationships for NOSTRIN Gene

Compound -log(P) Hits PubMed IDs
nitric oxide 44.5 8
genes like me logo Genes that share compounds with NOSTRIN: view

Transcripts for NOSTRIN Gene

Unigene Clusters for NOSTRIN Gene

Nitric oxide synthase trafficker:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOSTRIN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOSTRIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for NOSTRIN Gene

GeneLoc Exon Structure for
NOSTRIN
ECgene alternative splicing isoforms for
NOSTRIN

Expression for NOSTRIN Gene

mRNA expression in normal human tissues for NOSTRIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOSTRIN Gene

SOURCE GeneReport for Unigene cluster for NOSTRIN Gene Hs.189780

mRNA Expression by UniProt/SwissProt for NOSTRIN Gene

Q8IVI9-NOSTN_HUMAN
Tissue specificity: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
genes like me logo Genes that share expressions with NOSTRIN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NOSTRIN Gene

Orthologs for NOSTRIN Gene

This gene was present in the common ancestor of animals.

Orthologs for NOSTRIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOSTRIN 35
  • 99.54 (n)
  • 99.8 (a)
NOSTRIN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOSTRIN 35
  • 86.27 (n)
  • 81.98 (a)
NOSTRIN 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOSTRIN 35
  • 85.31 (n)
  • 82.02 (a)
NOSTRIN 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nostrin 35
  • 84.78 (n)
  • 82.61 (a)
Nostrin 16
Nostrin 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOSTRIN 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOSTRIN 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nostrin 35
  • 83.6 (n)
  • 82.2 (a)
lizard
(Anolis carolinensis)
Reptilia NOSTRIN 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nostrin 35
  • 64.04 (n)
  • 58.5 (a)
zebrafish
(Danio rerio)
Actinopterygii nostrin 35
  • 56.45 (n)
  • 47.18 (a)
nostrin 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010676 35
  • 44.2 (n)
  • 31.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42388 35
  • 43.39 (n)
  • 33.73 (a)
CG42388 36
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36E8.4 36
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for NOSTRIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOSTRIN Gene

ENSEMBL:
Gene Tree for NOSTRIN (if available)
TreeFam:
Gene Tree for NOSTRIN (if available)

Paralogs for NOSTRIN Gene

genes like me logo Genes that share paralogs with NOSTRIN: view

No data available for Paralogs for NOSTRIN Gene

Variants for NOSTRIN Gene

Sequence variations from dbSNP and Humsavar for NOSTRIN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3931 -- 168,864,871(-) CACCA(C/T)CCTCC reference, synonymous-codon
rs10181 -- 168,864,937(-) TTTGA(A/T)GGTAA synonymous-codon, reference
rs471087 -- 168,845,128(+) GCTCC(G/T)GGTAC intron-variant
rs472233 -- 168,832,237(-) TCCTC(C/T)TAGAA intron-variant
rs474538 -- 168,838,686(+) CCCAT(A/G)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOSTRIN Gene

Variant ID Type Subtype PubMed ID
nsv875381 CNV Loss 21882294
nsv516627 CNV Loss 19592680
nsv3023 CNV Insertion 18451855
esv999271 CNV Insertion 20482838
nsv227 CNV Insertion 15895083

Relevant External Links for NOSTRIN Gene

HapMap Linkage Disequilibrium report
NOSTRIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOSTRIN Gene

Disorders for NOSTRIN Gene

Relevant External Links for NOSTRIN

Genetic Association Database (GAD)
NOSTRIN
Human Genome Epidemiology (HuGE) Navigator
NOSTRIN
genes like me logo Genes that share disorders with NOSTRIN: view

No data available for UniProtKB/Swiss-Prot for NOSTRIN Gene

Publications for NOSTRIN Gene

  1. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. (PMID: 12446846) Zimmermann K. … Oess S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. (PMID: 16234328) Icking A. … Schilling K. (J. Cell Sci. 2005) 3 4 23
  3. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. (PMID: 16807357) Schilling K. … Icking A. (Mol. Biol. Cell 2006) 3 4 23
  4. NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. (PMID: 18980613) Wiesenthal A. … Siehoff-Icking A. (Traffic 2009) 3 4 23
  5. Endothelial nitric oxide synthase traffic inducer in the umbilical vessels of the patients with pre-eclampsia. (PMID: 19399414) Xiang W. … Xu X. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009) 3 23

Products for NOSTRIN Gene

Sources for NOSTRIN Gene

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