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NOSTRIN Gene

protein-coding   GIFtS: 59
GCID: GC02P169643

Nitric Oxide Synthase Trafficking

(Previous name: nitric oxide synthase trafficker)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nitric Oxide Synthase Trafficking1 2     DaIP22
Nitric Oxide Synthase Trafficker1 2 3     Endothelial Nitric Oxide Synthase Traffic Inducer2
Nitric Oxide Synthase Traffic Inducer2 3     ENOS Traffic Inducer2
BM247 Homolog2 3     nostrin2
ENOS-Trafficking Inducer2 3     Ortholog Of Mouse Disabled 2 Interacting Proein 22

External Ids:    HGNC: 202031   Entrez Gene: 1156772   Ensembl: ENSG000001630727   OMIM: 6074965   UniProtKB: Q8IVI93   

Export aliases for NOSTRIN gene to outside databases

Previous GC identifers: GC02P168186 GC02P169607 GC02P169861 GC02P169469 GC02P169367 GC02P161522


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOSTRIN Gene:
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and
vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM
163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures,
thereby attenuating ENOS-dependent NO production.(supplied by OMIM, Apr 2004)

GeneCards Summary for NOSTRIN Gene:
NOSTRIN (nitric oxide synthase trafficking) is a protein-coding gene.

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9
Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the
plasma membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOSTRIN gene promoter:
         MEF-2A   CREB   Sox5   deltaCREB   aMEF-2   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOSTRIN promoter sequence
   Search Chromatin IP Primers for NOSTRIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOSTRIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q31.1

NOSTRIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOSTRIN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P169643:  view genomic region     (about GC identifiers)

Start:
169,643,049 bp from pter      End:
169,722,024 bp from pter
Size:
78,976 bases      Orientation:
plus strand

1 alternative location:
Chr2+,NW_003315909 51-34,979     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9 (See protein sequence)
Recommended Name: Nostrin  
Size: 506 amino acids; 57660 Da
Subunit: Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1
1 PDB 3D structure from and Proteopedia for NOSTRIN:
2YUN (3D)    
Secondary accessions: A8K2I9 B3KSF5 E7EPT9 Q27HG3 Q53S62 Q96CJ9
Alternative splicing: 4 isoforms:  Q8IVI9-1   Q8IVI9-2   Q8IVI9-3   Q8IVI9-4   (No experimental confirmation available. Ref.3 (BAG52717) sequence is in conflict in position: 238:T->I)

Explore the universe of human proteins at neXtProt for NOSTRIN: NX_Q8IVI9

Explore proteomics data for NOSTRIN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOSTRIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001034813.2  NP_001165102.1  NP_001165103.1  NP_443178.2  

    ENSEMBL proteins: 
     ENSP00000402140   ENSP00000318921   ENSP00000415337   ENSP00000404413   ENSP00000380390  
     ENSP00000380392   ENSP00000401316   ENSP00000390383   ENSP00000388597   ENSP00000394051  
    Reactome Protein details: Q8IVI9

    NOSTRIN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NOSTRIN
    OriGene Protein Over-expression Lysate for NOSTRIN
    OriGene MassSpec for NOSTRIN
    OriGene Custom Protein Services for NOSTRIN
    GenScript Custom Purified and Recombinant Proteins Services for NOSTRIN
    Novus Biologicals NOSTRIN Protein
    Novus Biologicals NOSTRIN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOSTRIN

     
    Search eBioscience for Proteins for NOSTRIN 

     
    antibodies-online proteins for NOSTRIN (4 products) 

     
    antibodies-online peptides for NOSTRIN

    NOSTRIN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for NOSTRIN
    Novus Biologicals NOSTRIN Antibody
    Abcam antibodies for NOSTRIN
    Cloud-Clone Corp. Antibodies for NOSTRIN
    Search ThermoFisher Antibodies for NOSTRIN
    antibodies-online antibodies for NOSTRIN (25 products) 

    NOSTRIN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOSTRIN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOSTRIN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOSTRIN
    Cloud-Clone Corp. CLIAs for NOSTRIN
    Search eBioscience for ELISAs for NOSTRIN 
    antibodies-online kits for NOSTRIN (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028535 Nostrin
     IPR001060 FCH_dom
     IPR011072 HR1_rho-bd
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q8IVI9

    ProtoNet protein and cluster: Q8IVI9

    3 Blocks protein domains:
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9
    Domain: The SH3 domain mediates interaction with NOS3, DNM2 and WASL
    Domain: The FCH domain is necessary for membrane targeting
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with NOSTRIN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOSTN_HUMAN, Q8IVI9
    Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the
    plasma membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI12446846
         
    Find genes that share ontologies with NOSTRIN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOSTRIN:
     Decreased influenza A virus in  Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nostrin):
     cardiovascular system  vision/eye 

    Find genes that share phenotypes with NOSTRIN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nostrintm1.1Oess for NOSTRIN

       genOway: Develop your customized and physiologically relevant rodent model for NOSTRIN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NOSTRIN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOSTRIN:
    hsa-miR-518a-5p hsa-miR-1182 hsa-miR-3914
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOSTRIN
    Predesigned siRNA for gene silencing in human, mouse, rat NOSTRIN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOSTRIN

    Clone
    Products:
         
    OriGene clones in human, mouse for NOSTRIN (see all 21)
    OriGene ORF clones in mouse, rat for NOSTRIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NOSTRIN (NM_052946)
    Sino Biological Human cDNA Clone for NOSTRIN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSTRIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSTRIN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOSTRIN
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOSTRIN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSTRIN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOSTN_HUMAN, Q8IVI9: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle.
    Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with NOSTRIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOSTRIN About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of nitric oxide
    Metabolism of nitric oxide
    eNOS activation and regulation0.00
    NOSTRIN mediated eNOS trafficking0.00
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with NOSTRIN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NOSTRIN
        eNOS Signaling


    1 Reactome Pathway for NOSTRIN
        NOSTRIN mediated eNOS trafficking


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOSTRIN: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOSTRIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for NOSTRIN (Q8IVI91, 2, 3 ENSP000003189214) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR1P113621, 2EBI-1391643,EBI-1028277 MINT-8404357 MINT-8404389 MINT-8404338 MINT-8404370 MINT-8403601
    NOS3P294741, 2, 3, ENSP000002974944EBI-1391643,EBI-1391623 MINT-7213409 MINT-7213465 I2D: score=2 STRING: ENSP00000297494
    DNM1Q051931, 2, ENSP000003620144EBI-1391643,EBI-713135 MINT-7213470 MINT-7213417 MINT-7213439 STRING: ENSP00000362014
    APCP250543, ENSP000002574304I2D: score=2 STRING: ENSP00000257430
    DAB2P980823, ENSP000003133914I2D: score=2 STRING: ENSP00000313391
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0045892negative regulation of transcription, DNA-templated IEA--
    GO:0046209nitric oxide metabolic process TAS--

    Find genes that share ontologies with NOSTRIN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOSTRIN (NOSTN)

    1 Novoseek inferred chemical compound relationship for NOSTRIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 44.5 9 16807357 (2), 15847871 (2), 12446846 (1), 16961293 (1) (see all 6)



    Find genes that share compounds with NOSTRIN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOSTRIN gene (4 alternative transcripts): 
    NM_001039724.3  NM_001171631.1  NM_001171632.1  NM_052946.3  

    Unigene Cluster for NOSTRIN:

    Nitric oxide synthase trafficker
    Hs.189780  [show with all ESTs]
    Unigene Representative Sequence: NM_001171631
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458381(uc002uef.3) ENST00000317647 ENST00000439509 ENST00000445023
    ENST00000397206 ENST00000471833 ENST00000397209 ENST00000421711 ENST00000447264
    ENST00000486873 ENST00000427068 ENST00000472260(uc002uek.3) ENST00000495202
    ENST00000444448(uc002ueg.3 uc002ueh.3 uc010fpu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOSTRIN using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOSTRIN:
    hsa-miR-518a-5p hsa-miR-1182 hsa-miR-3914
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOSTRIN
    Predesigned siRNA for gene silencing in human, mouse, rat NOSTRIN
    Clone
    Products:
         
    OriGene clones in human, mouse for NOSTRIN (see all 21)
    OriGene ORF clones in mouse, rat for NOSTRIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NOSTRIN (NM_052946)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSTRIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSTRIN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOSTRIN
    OriGene qSTAR qPCR primer pairs in human, mouse for NOSTRIN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOSTRIN
      QuantiTect SYBR Green Assays in human, mouse, rat NOSTRIN
      QuantiFast Probe-based Assays in human, mouse, rat NOSTRIN

    Additional mRNA sequence: 

    AJ532842.1 AK002203.2 AK093444.1 AK290254.1 BC014189.2 BC093072.1 DQ402497.1 

    12 DOTS entries:

    DT.100749575  DT.92419907  DT.100024433  DT.97818592  DT.100689724  DT.101964827  DT.91968115  DT.86856210 
    DT.92419904  DT.95256736  DT.95345143  DT.95113606 

    Selected AceView cDNA sequences (see all 67):

    AI381494 BG539611 AL709845 BM955544 BI767159 AI191150 AL541553 BM970865 
    AU139524 AL550371 BX470974 BI830617 BI772413 BI819475 CD359047 BX951045 
    BM923721 BP349598 BG481943 BX488387 AV704960 BG776865 BM795984 BP362251 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NOSTRIN    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22
    SP1:                                                                                                        -     -           -                                 
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                              -                                             
    SP4:                                                                                                                                                            


    ECgene alternative splicing isoforms for NOSTRIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOSTRIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACGCAG
    NOSTRIN Expression
    About this image


    NOSTRIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
    NOSTRIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOSTRIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.189780

    UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9
    Tissue specificity: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in
    brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from
    women with pre-eclampsia (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOSTRIN: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOSTRIN
    OriGene qSTAR qPCR primer pairs in human, mouse for NOSTRIN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOSTRIN
    QuantiTect SYBR Green Assays in human, mouse, rat NOSTRIN
    QuantiFast Probe-based Assays in human, mouse, rat NOSTRIN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSTRIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NOSTRIN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nostrin1 , 5 nitric oxide synthase trafficker1, 5 84.78(n)1
    82.61(a)1
      2 (39.58 cM)5
    3294161  NM_181547.31  NP_853525.31 
     691358005 
    lizard
    (Anolis carolinensis)
    Reptilia NOSTRIN6
    nitric oxide synthase trafficking
    50(a)
    1 ↔ 1
    1(245304092-245371522)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nostrin1 nitric oxide synthase trafficker 64.04(n)
    58.5(a)
      100489418  XM_002936754.2  XP_002936800.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nostrin1 nitric oxide synthase trafficker 56.45(n)
    47.18(a)
      100148449  NM_001113604.1  NP_001107076.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423881 CG42388 43.39(n)
    33.73(a)
      8673992  NM_001169240.2  NP_001162711.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C36E8.46
    Protein C36E8.4 (C36E8.4) mRNA, complete cds
    17(a)
    1 ↔ 1
    III(4012336-4015763) WBGene00007983


    ENSEMBL Gene Tree for NOSTRIN (if available)
    TreeFam Gene Tree for NOSTRIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOSTRIN gene
    17 SIMAP similar genes for NOSTRIN using alignment to 6 protein entries:     NOSTN_HUMAN (see all proteins):
    HINFP    PUS1    PPP2R5C    ARHGEF7    TUBA1C    SH3GL2
    SH3KBP1    SH3GL1    TFR2    SLC35E3    ATF1    ITSN1
    DYNC2LI1    LDLRAD3    PPP5D1    PFKFB3    NUP93

    Find genes that share paralogs with NOSTRIN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOSTRIN (see all 1757)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114084401,2
    C--169108991(+) GTCTT-/AAAAAA 4 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1147179931,2
    F--169645036(+) AGTTGG/TAGGAG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1911002851,2
    --169645056(+) AGAATC/GAAAGC 1 -- int10--------
    rs1836788041,2
    --169645182(+) AAGGCA/GTAAAT 1 -- int10--------
    rs1869891231,2
    --169645189(+) AAATAC/TATTAA 1 -- int10--------
    rs1457764581,2
    C--169645214(+) AGTTTC/TTCACT 1 -- int10--------
    rs1158425521,2
    F--169645238(+) GGTGTA/CAATAT 1 -- int11Minor allele frequency- C:0.05WA 118
    rs1481531531,2
    --169645300(+) TATCCA/GTGTAT 1 -- int10--------
    rs1162486161,2
    C,F--169645346(+) TGTTAA/GGTGTG 1 -- int12Minor allele frequency- G:0.01WA NA 238
    rs1917843751,2
    --169645380(+) GTGTGC/TGTATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOSTRIN (169643049 - 169722024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NOSTRIN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv227CNV Insertion15895083
    esv999271CNV Insertion20482838
    nsv3023CNV Insertion18451855
    nsv516627CNV Loss19592680
    nsv875381CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOSTRIN
    DNA2.0 Custom Variant and Variant Library Synthesis for NOSTRIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607496    OMIM disorders: --


    Find genes that share disorders with NOSTRIN           About GenesLikeMe

    Genetic Association Database (GAD): NOSTRIN
    Human Genome Epidemiology (HuGE) Navigator: NOSTRIN (3 documents)

    Export disorders for NOSTRIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOSTRIN gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with NOSTRIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. (PubMed id 12446846)1, 2, 3, 9 Zimmermann K....Oess S. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. (PubMed id 16234328)1, 2, 9 Icking A....Schilling K. (J. Cell Sci. 2005)
    3. Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. (PubMed id 16807357)1, 2, 9 Schilling K.... Icking A. (Mol. Biol. Cell 2006)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1, 4 Holt R....Monaco A.P. (Eur. J. Hum. Genet. 2010)
    6. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. (PubMed id 16376344)2, 9 Icking A.... Mueller-Esterl W. (FEBS Lett. 2006)
    9. NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. (PubMed id 18980613)1, 9 Wiesenthal A....Siehoff-Icking A. (Traffic 2009)
    10. Endothelial nitric oxide synthase traffic inducer in the umbilical vessels of the patients with pre-eclampsia. (PubMed id 19399414)1, 9 Xiang W....Xu X. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115677 HGNC: 20203 AceView: NOSTRIN Ensembl:ENSG00000163072 euGenes: HUgn115677
    ECgene: NOSTRIN H-InvDB: NOSTRIN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOSTRIN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOSTRIN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOSTRIN gene:
    Search GeneIP for patents involving NOSTRIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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