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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NOSTRIN Gene

protein-coding GIFtS: 56
GCID: GC02P169643

nitric oxide synthase trafficker

Explore 8 diseases affiliated with
NOSTRIN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nitric Oxide Synthase Trafficker¹ ² ³		Endothelial Nitric Oxide Synthase Traffic Inducer²
Nitric Oxide Synthase Traffic Inducer² ³		ENOS Traffic Inducer²
BM247 Homolog² ³		Nitric Oxide Synthase Trafficking²
ENOS-Trafficking Inducer² ³		Nostrin¹
MGC20702¹		Ortholog Of Mouse Disabled 2 Interacting Proein 2²
DaIP2²

External Ids:	HGNC: 20203¹	Entrez Gene: 115677²	Ensembl: ENSG00000163072⁷	OMIM: 607496⁵	UniProtKB: Q8IVI9³

Export aliases for NOSTRIN gene to outside databases

Previous GC identifers: GC02P168186 GC02P169607 GC02P169861 GC02P169469 GC02P169367 GC02P161522

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOSTRIN:

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and

vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM

163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures,

thereby attenuating ENOS-dependent NO production.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9

Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the

plasma membrane

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NOSTRIN gene promoter:
MEF-2A CREB Sox5 deltaCREB aMEF-2 RORalpha2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOSTRIN promoter sequence

Search SABiosciences Chromatin IP Primers for NOSTRIN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOSTRIN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q31.1

NOSTRIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOSTRIN gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P169643: view genomic region (about GC identifiers)

Start:	169,643,049 bp from pter	End:	169,722,024 bp from pter
Size:	78,976 bases	Orientation:	plus strand

1 alternative location:

Chr2+,PATCHES 169,678,429-169,713,357

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9 (See protein sequence)

Recommended Name: Nostrin

Size: 506 amino acids; 57660 Da

Subunit: Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm,

cytoskeleton. Note=Enriched in selected actin structures

1 PDB 3D structure from and Proteopedia for NOSTRIN:

2YUN (3D)

Secondary accessions: A8K2I9 B3KSF5 E7EPT9 Q27HG3 Q53S62 Q96CJ9

Alternative splicing: 4 isoforms: Q8IVI9-1 Q8IVI9-2 Q8IVI9-3 Q8IVI9-4 (No experimental confirmation available. Ref.3 (BAG52717) sequence is in conflict in position: 238:T->I)

Explore the universe of human proteins at neXtProt for NOSTRIN: NX_Q8IVI9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVI9

NOSTRIN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001034813.2 NP_001165102.1 NP_001165103.1 NP_443178.2

ENSEMBL proteins:

ENSP00000402140 ENSP00000318921 ENSP00000415337 ENSP00000404413 ENSP00000380390

ENSP00000380392 ENSP00000401316 ENSP00000390383 ENSP00000388597 ENSP00000394051

Reactome Protein details: Q8IVI9
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NOSTRIN OriGene Protein Over-expression Lysate (see all 2): NOSTRIN OriGene Custom Protein Services for NOSTRIN
	GenScript Custom Purified and Recombinant Proteins Services for NOSTRIN
	Novus Biologicals NOSTRIN Protein Novus Biologicals NOSTRIN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NOSTRIN

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0030666	endocytic vesicle membrane	TAS	--

NOSTRIN for ontologies About GeneDecksing

NOSTRIN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NOSTRIN
	GenScript Custom Superior Antibodies Services for NOSTRIN
	Novus Biologicals NOSTRIN Antibody
	Search for Antibodies for NOSTRIN at Abcam
	Uscn Antibodies for NOSTRIN
	Search ThermoFisher Antibodies for NOSTRIN

Assay Products for NOSTRIN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NOSTRIN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NOSTRIN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NOSTRIN for domains About GeneDecksing

2 InterPro domains/families:

IPR001060 FCH

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q8IVI9

ProtoNet protein and cluster: Q8IVI9

3 Blocks protein families:

IPB001060 Cdc15/Fes/CIP4

IPB001452 SH3 domain signature

IPB011072 Protein kinase PKN/PRK1

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9

Domain: The SH3 domain mediates interaction with NOS3, DNM2 and WASL

Domain: The FCH domain is necessary for membrane targeting

Similarity: Contains 1 FCH domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9

Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the

plasma membrane

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NOSTRIN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOSTRIN
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate NOSTRIN:
		hsa-miR-518a-5p hsa-miR-1182 hsa-miR-3914
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOSTRIN (see all 7) OriGene shRNA RFP: NOSTRIN OriGene siRNA: NOSTRIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOSTRIN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NOSTRIN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOSTRIN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOSTRIN (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): NOSTRIN (NM_052946)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSTRIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSTRIN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOSTRIN
		Search LifeMap BioReagents cell lines for NOSTRIN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSTRIN

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0005515	protein binding	IPI	12446846

NOSTRIN for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NOSTRIN:

Decreased influenza A virus in

Increased S DNA content

Animal Models:
Mouse knock-out Nostrin^tm1.1Oess for NOSTRIN
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nostrin):

cardiovascular system

vision/eye

NOSTRIN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism of nitric oxide

	eNOS activation and regulation	1.00			NOSTRIN mediated translocation of eNOS from plasma membrane	0.29
	Metabolism of nitric oxide	1.00			NOSTRIN mediated eNOS trafficking	0.29

Metabolism

Metabolism

1.00

Nanog in Mammalian ESC Pluripotency

eNOS Signaling

0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NOSTRIN

eNOS Signaling

5 Reactome Pathways for NOSTRIN

	NOSTRIN mediated eNOS trafficking
	eNOS activation and regulation
	Metabolism of nitric oxide
	Metabolism
	NOSTRIN mediated translocation of eNOS from plasma membrane

NOSTRIN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NOSTRIN

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/12 Interacting proteins for NOSTRIN (Q8IVI9^{1, 2, 3} ENSP00000318921⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOS3	P29474¹^,²^,³, ENSP00000297494⁴	EBI-1391643,EBI-1391623 MINT-7213409 MINT-7213465 I2D: score=2 STRING: ENSP00000297494
FGFR1	P11362²	MINT-8404357 MINT-8404389 MINT-8404338 MINT-8404370 MINT-8403601
DNM1	Q05193², ENSP00000362014⁴	MINT-7213470 MINT-7213417 MINT-7213439 STRING: ENSP00000362014
APC	P25054³, ENSP00000257430⁴	I2D: score=2 STRING: ENSP00000257430
DAB2	P98082³, ENSP00000313391⁴	I2D: score=2 STRING: ENSP00000313391

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0045892	negative regulation of transcription, DNA-dependent	--	--
GO:0046209	nitric oxide metabolic process	TAS	--
GO:0050999	regulation of nitric-oxide synthase activity	TAS	--

NOSTRIN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NOSTRIN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NOSTRIN
1 Novoseek chemical compound relationship for NOSTRIN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide	44.5	9	16807357 (2), 15847871 (2), 12446846 (1), 16961293 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about NOSTRIN / NOSTN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NOSTRIN gene (4 alternative transcripts):

NM_001039724.3 NM_001171631.1 NM_001171632.1 NM_052946.3

Unigene Cluster for NOSTRIN:

Nitric oxide synthase trafficker

Hs.189780 [show with all ESTs]

Unigene Representative Sequence: NM_001171631

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000458381(uc002uef.3) ENST00000317647 ENST00000439509 ENST00000445023

ENST00000397206 ENST00000471833 ENST00000397209 ENST00000421711 ENST00000447264

ENST00000486873 ENST00000427068 ENST00000472260(uc002uek.3) ENST00000495202

ENST00000444448(uc002ueg.3 uc002ueh.3 uc010fpu.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NOSTRIN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOSTRIN
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate NOSTRIN:
		hsa-miR-518a-5p hsa-miR-1182 hsa-miR-3914
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOSTRIN (see all 7) OriGene shRNA RFP: NOSTRIN OriGene siRNA: NOSTRIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOSTRIN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOSTRIN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOSTRIN (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): NOSTRIN (NM_052946)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSTRIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSTRIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOSTRIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NOSTRIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOSTRIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOSTRIN

Additional cDNA sequence:

AJ532842.1 AK002203.2 AK093444.1 AK290254.1 BC014189.2 BC093072.1 DQ402497.1

12 DOTS entries:

DT.100749575 DT.92419907 DT.100024433 DT.97818592 DT.100689724 DT.101964827 DT.91968115 DT.86856210

DT.92419904 DT.95256736 DT.95345143 DT.95113606

24/67 AceView cDNA sequences (see all 67):

BG539611 AI381494 AL541553 BI767159 AI191150 AL709845 BM955544 BM923721

BM795984 BG776865 BM970865 BX470974 CD359047 BI830617 AL550371 BM955549

CB266027 AV704960 BP362937 BX951045 BI768243 CD516145 BM908187 BG481943

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for NOSTRIN About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21	^	22
SP1:																																			-		-				-
SP2:																																									-
SP3:																																					-
SP4:

ECgene alternative splicing isoforms for NOSTRIN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOSTRIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACACGCAG

About this image

NOSTRIN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Endoderm progenitor-like cells (Generation and expan...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NOSTRIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOSTRIN

SOURCE GeneReport for Unigene cluster: Hs.189780

UniProtKB/Swiss-Prot: NOSTN_HUMAN, Q8IVI9

Tissue specificity: Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain,

thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with

pre-eclampsia (at protein level)

SABiosciences Expression via Pathway-Focused PCR Arrays including NOSTRIN:

Hypertension in human mouse rat

Neurotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOSTRIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NOSTRIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOSTRIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOSTRIN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSTRIN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NOSTRIN gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	NOSTRIN⁶	--	50(a)	1 ↔ 1	1(245310501-245358205)
zebrafish (Danio rerio)	Actinopterygii	nostrin¹	nitric oxide synthase trafficker	56.99(n) 46.98(a)		100148449 NM_001113604.1 NP_001107076.1
fruit fly (Drosophila melanogaster)	Insecta	CG42388¹	CG42388	43.47(n) 33.73(a)		8673992 NM_001201638.1 NP_001188567.1
worm (Caenorhabditis elegans)	Secernentea	C36E8.4¹	Protein C36E8.4	39.4(n) 23.46(a)		183279 NM_065404.4 NP_497805.2

ENSEMBL Gene Tree for NOSTRIN (if available)
TreeFam Gene Tree for NOSTRIN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182260548^1,2		--	169641052(+)	`CAGACC/TGGAGT`	3	--	us2k¹ int¹		0	--	--	--	--
rs78150760^1,2	F,	--	169641081(+)	`TACTCA/TTTCTG`	3	--	us2k¹ int¹		1		WA	118
rs150309363^1,2		--	169641173(+)	`TTGGC-/TTTTTT`	3	--	us2k¹ int¹		0	--	--	--	--
rs186539726^1,2		--	169641181(+)	`TTTTTG/TTTAAT`	3	--	us2k¹ int¹		0	--	--	--	--
rs76702193^1,2	F,	--	169641439(+)	`ATAACC/TCAGAA`	3	--	int¹ us2k¹		1		WA	118
rs148205867^1,2		--	169641466(+)	`ACCAGC/TACAAG`	3	--	int¹ us2k¹		0	--	--	--	--
rs190947833^1,2		--	169641488(+)	`TTCAAA/TACATT`	3	--	int¹ us2k¹		0	--	--	--	--
rs141199959^1,2		--	169641552(+)	`TGGGTC/TTTAAG`	3	--	int¹ us2k¹		0	--	--	--	--
rs183760365^1,2		--	169641606(+)	`AGTAGA/GTGAGG`	3	--	int¹ us2k¹		0	--	--	--	--
rs3732030^1,2	C,F,H,	--	169641629(+)	`CAAAGC/TGAGTT`	3	--	us2k¹ int¹		7		NS EA NA	660

HapMap Linkage Disequilibrium report for NOSTRIN (169643049 - 169722024 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for NOSTRIN
7 CNVs: 35753 0533 35755 50330 35756 35754 35757

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOSTRIN

DNA2.0 Custom Variant and Variant Library Synthesis for NOSTRIN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NOSTRIN for disorders           About GeneDecksing

OMIM gene information: 607496    OMIM disorders: --

8 diseases for NOSTRIN:    About MalaCards

pre-eclampsia autism spectrum disorder eclampsia alcoholic hepatitis

alcoholism hepatitis hypertension cerebritis

Human Genome Epidemiology (HuGE) Navigator: NOSTRIN (3 documents)

Export disorders for NOSTRIN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NOSTRIN gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with NOSTRIN)

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NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. (PubMed id 12446846)^{1, 2, 3, 9} Zimmermann K....Oess S. (2002)
NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. (PubMed id 16234328)^{1, 2, 9} Icking A....Schilling K. (2005)
Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. (PubMed id 16807357)^{1, 2, 9} Schilling K.... Icking A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN. (PubMed id 16376344)^{2, 9} Icking A.... Mueller-Esterl W. (2006)
NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation. (PubMed id 18980613)^{1, 9} Wiesenthal A....Siehoff-Icking A. (2009)
Endothelial nitric oxide synthase traffic inducer in the umbilical vessels of the patients with pre-eclampsia. (PubMed id 19399414)^{1, 9} Xiang W....Xu X. (2009)
Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with pre-eclampsia. (PubMed id 15847871)^{2, 9} Xiang W.... Jiang R. (2005)
Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN. (PubMed id 15596140)^{1, 9} Choi Y.J....Park S.S. (2005)
Platelet-endothelial cell adhesion molecule-1 regulat es endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression. (PubMed id 21183735)¹ McCormick M.E....Tzima E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115677	HGNC: 20203	AceView: NOSTRIN	Ensembl:ENSG00000163072	euGenes: HUgn115677
ECgene: NOSTRIN	H-InvDB: NOSTRIN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NOSTRIN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NOSTRIN	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NOSTRIN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NOSTRIN gene:
Search GeneIP for patents involving NOSTRIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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nitric oxide synthase trafficker

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nitric oxide synthase trafficker

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