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NOSIP Gene(Protein Coding)

Nitric Oxide Synthase Interacting Protein

GCID:
GC19M049555
GIFtS:
54
Genes Participants
UDN Logo

Aliases for NOSIP Gene

Aliases for NOSIP Gene

  • Nitric Oxide Synthase Interacting Protein 2 3 5
  • E3 Ubiquitin-Protein Ligase NOSIP 3 4
  • ENOS-Interacting Protein 3 4
  • EC 6.3.2.- 4
  • CGI-25 3

External Ids for NOSIP Gene

Previous GeneCards Identifiers for NOSIP Gene

  • GC19M050717
  • GC19M050427
  • GC19M054734
  • GC19M054751
  • GC19M054752
  • GC19M054753
  • GC19M050058
  • GC19M046436

Summaries for NOSIP Gene

Entrez Gene Summary for NOSIP Gene

  • The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

GeneCards Summary for NOSIP Gene

NOSIP (Nitric Oxide Synthase Interacting Protein) is a Protein Coding gene. Among its related pathways are eNOS activation and regulation and Metabolism. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NOSIP Gene

  • E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).

Gene Wiki entry for NOSIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOSIP Gene

Genomics for NOSIP Gene

Products:

  1. Regulatory Element

Regulatory Elements for NOSIP Gene

Enhancers for NOSIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOSIP on UCSC Golden Path with GeneCards custom track

Promoters for NOSIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOSIP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NOSIP gene promoter:

Genomic Location for NOSIP Gene

Chromosome:
19
Start:
49,555,468 bp from pter
End:
49,590,262 bp from pter
Size:
34,795 bases
Orientation:
Minus strand

Genomic View for NOSIP Gene

Genes around NOSIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOSIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOSIP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NOSIP Gene

Proteins for NOSIP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NOSIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y314-NOSIP_HUMAN
    Recommended name:
    Nitric oxide synthase-interacting protein
    Protein Accession:
    Q9Y314
    Secondary Accessions:
    • Q96FD2

    Protein attributes for NOSIP Gene

    Size:
    301 amino acids
    Molecular mass:
    33172 Da
    Quaternary structure:
    • Interacts with NOS1 and NOS3 (PubMed:11149895, PubMed:15548660). Interacts with PP2A holoenzyme, containing PPP2CA, PPP2CB, PPP2R1A and PPP2R2A subunits (By similarity).

neXtProt entry for NOSIP Gene

Proteomics data for NOSIP Gene at MOPED

Protein Expression for NOSIP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NOSIP Gene

  • Ubiquitination at Lys 117, Lys 157, Lys 253, and Lys 294
  • Modification sites at PhosphoSitePlus

Other Protein References for NOSIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NOSIP

No data available for DME Specific Peptides for NOSIP Gene

Domains & Families for NOSIP Gene

Protein Domains for NOSIP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOSIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y314

UniProtKB/Swiss-Prot:

NOSIP_HUMAN :
  • The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
  • Belongs to the NOSIP family.
Domain:
  • The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
Family:
  • Belongs to the NOSIP family.
genes like me logo Genes that share domains with NOSIP: view

No data available for Gene Families for NOSIP Gene

Function for NOSIP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for NOSIP Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).

Enzyme Numbers (IUBMB) for NOSIP Gene

Gene Ontology (GO) - Molecular Function for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NOSIP: view

Phenotypes for NOSIP Gene

GenomeRNAi human phenotypes for NOSIP:
genes like me logo Genes that share phenotypes with NOSIP: view

Animal Model Products

miRNA for NOSIP Gene

miRTarBase miRNAs that target NOSIP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOSIP Gene

Localization for NOSIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOSIP Gene

Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOSIP Gene COMPARTMENTS Subcellular localization image for NOSIP gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 4
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with NOSIP: view

Pathways & Interactions for NOSIP Gene

genes like me logo Genes that share pathways with NOSIP: view

Pathways by source for NOSIP Gene

1 Qiagen pathway for NOSIP Gene

Interacting Proteins for NOSIP Gene

Selected Interacting proteins: Q9Y314-NOSIP_HUMAN for NOSIP Gene via I2D

Gene Ontology (GO) - Biological Process for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008152 metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NOSIP: view

No data available for SIGNOR curated interactions for NOSIP Gene

Drugs & Compounds for NOSIP Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NOSIP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NOSIP Gene

(7) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(372) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOSIP Gene

Nitric oxide synthase interacting protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOSIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7:
SP8: - - - -
SP9: -
SP10: - -

Relevant External Links for NOSIP Gene

GeneLoc Exon Structure for
NOSIP
ECgene alternative splicing isoforms for
NOSIP

Expression for NOSIP Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NOSIP Gene

mRNA expression in normal human tissues for NOSIP Gene
mRNA expression by BioGPS for NOSIP GenemRNA expression by GTEx for NOSIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOSIP Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for NOSIP Gene

This gene is overexpressed in Breast (43.4) and Lymph node (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NOSIP Gene



SOURCE GeneReport for Unigene cluster for NOSIP Gene Hs.7236

mRNA Expression by UniProt/SwissProt for NOSIP Gene

Q9Y314-NOSIP_HUMAN
Tissue specificity: Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
genes like me logo Genes that share expression patterns with NOSIP: view

Protein tissue co-expression partners for NOSIP Gene

- Elite partner

Primer Products

Orthologs for NOSIP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOSIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia NOSIP 35
  • 91.03 (n)
  • 94.68 (a)
NOSIP 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia NOSIP 35
  • 88.26 (n)
  • 92.69 (a)
NOSIP 36
  • 67 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nosip 35
  • 85.83 (n)
  • 90.7 (a)
Nosip 16
Nosip 36
  • 91 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia NOSIP 35
  • 98.89 (n)
  • 99 (a)
NOSIP 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Nosip 35
  • 85.94 (n)
  • 91.69 (a)
oppossum
(Monodelphis domestica)
 Mammalia NOSIP 36
  • 84 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 38 (a)
 OneToMany
-- 36
  • 84 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia NOSIP 36
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia MGC75989 35
nosip 35
  • 65.88 (n)
  • 72.82 (a)
zebrafish
(Danio rerio)
 Actinopterygii -- 35
nosip 35
  • 63.41 (n)
  • 68.01 (a)
nosip 36
  • 64 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG6179 37
  • 48 (a)
CG6179 35
  • 59.8 (n)
  • 53.04 (a)
CG6179 36
  • 47 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005654 35
  • 58.97 (n)
  • 54.9 (a)
worm
(Caenorhabditis elegans)
 Secernentea R05G6.4 35
  • 48.51 (n)
  • 48.28 (a)
R05G6.4 36
  • 43 (a)
 OneToOne
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G61620 35
  • 44.29 (n)
  • 33.57 (a)
rice
(Oryza sativa)
 Liliopsida Os03g0279900 35
  • 46.16 (n)
  • 33.45 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 50 (a)
 OneToOne
Species with no ortholog for NOSIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOSIP Gene

ENSEMBL:
Gene Tree for NOSIP (if available)
TreeFam:
Gene Tree for NOSIP (if available)

Paralogs for NOSIP Gene

No data available for Paralogs for NOSIP Gene

Variants for NOSIP Gene

Sequence variations from dbSNP and Humsavar for NOSIP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17850728 - 49,556,909(+) CGGGC(A/G)TCAGC reference, missense
rs7258960 -- 49,578,115(+) taaat(C/T)atatc intron-variant, upstream-variant-2KB
rs12982495 -- 49,562,224(+) taaag(C/T)gattc intron-variant
rs8102979 -- 49,566,637(+) AACTG(A/G)TTCAA intron-variant
rs8103289 -- 49,566,790(+) atata(C/T)ataca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOSIP Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv833862 CNV Loss 17160897
nsv912265 CNV Loss 21882294
nsv833863 CNV Loss 17160897
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897

Variation tolerance for NOSIP Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOSIP Gene

Disorders for NOSIP Gene

Relevant External Links for NOSIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOSIP

No disorders were found for NOSIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOSIP Gene

Publications for NOSIP Gene

  1. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PMID: 11149895) Dedio J. … Mueller-Esterl W. (FASEB J. 2001) 2 3 4 67
  2. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PMID: 16135813) Schleicher M. … Oess S. (Mol. Cell. Biol. 2005) 3 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NOSIP Gene

Sources for NOSIP Gene

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