Aliases for NOSIP Gene
Aliases for NOSIP Gene
External Ids for NOSIP Gene
- HGNC: 17946
- Entrez Gene: 51070
- Ensembl: ENSG00000142546
- OMIM: 616759
- UniProtKB: Q9Y314
Previous GeneCards Identifiers for NOSIP Gene
- GC19M050717
- GC19M050427
- GC19M054734
- GC19M054751
- GC19M054752
- GC19M054753
- GC19M050058
- GC19M046436
Summaries for NOSIP Gene
-
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
GeneCards Summary for NOSIP Gene
NOSIP (Nitric Oxide Synthase Interacting Protein) is a Protein Coding gene. Among its related pathways are Metabolism and eNOS activation and regulation.
UniProtKB/Swiss-Prot for NOSIP Gene
-
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOSIP Gene
Genomics for NOSIP Gene
GeneHancer (GH) Regulatory Elements for NOSIP Gene
Regulatory Element Products
Genomic Locations for NOSIP Gene
- chr19:49,555,468-49,590,262
- (GRCh38/hg38)
- Size:
- 34,795 bases
- Orientation:
- Minus strand
- chr19:50,058,968-50,093,519
- (GRCh37/hg19)
Genomic View for NOSIP Gene
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC


RefSeq DNA sequence for NOSIP Gene
Proteins for NOSIP Gene
-
Protein details for NOSIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y314-NOSIP_HUMAN
- Recommended name:
- Nitric oxide synthase-interacting protein
- Protein Accession:
- Q9Y314
- Q96FD2
Protein attributes for NOSIP Gene
- Size:
- 301 amino acids
- Molecular mass:
- 33172 Da
- Quaternary structure:
-
- Interacts with NOS1 and NOS3 (PubMed:11149895, PubMed:15548660). Interacts with PP2A holoenzyme, containing PPP2CA, PPP2CB, PPP2R1A and PPP2R2A subunits (By similarity).
Protein Expression for NOSIP Gene
Post-translational modifications for NOSIP Gene
- Ubiquitination at Lys117, Lys157, isoforms=253, and Lys294
Other Protein References for NOSIP Gene
Antibody Products
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-
Santa Cruz Biotechnology (SCBT) Antibodies for NOSIP
Protein Products
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OriGene Purified Proteins for NOSIP
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-
Abcam proteins for NOSIP
Assay Products
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Cloud-Clone Corp. Assay Kits for NOSIP
- antibodies-online: Search results for 8 available NOSIP Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for NOSIP Gene
Domains & Families for NOSIP Gene
Gene Families for NOSIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NOSIP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NOSIP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y314UniProtKB/Swiss-Prot:
NOSIP_HUMAN :- The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
- Belongs to the NOSIP family.
- Domain:
-
- The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
- Family:
-
- Belongs to the NOSIP family.
Function for NOSIP Gene
Molecular function for NOSIP Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).
Enzyme Numbers (IUBMB) for NOSIP Gene
Phenotypes From GWAS Catalog for NOSIP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IDA,HDA | 22658674 |
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 11149895 |
GO:0016740 | transferase activity | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IBA,IEA | -- |
Phenotypes for NOSIP Gene
- GenomeRNAi human phenotypes for NOSIP:
Animal Model Products
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miRNA for NOSIP Gene
- miRTarBase miRNAs that target NOSIP
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NOSIP
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOSIP Gene
Localization for NOSIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for NOSIP Gene
- Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
- Nucleus (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005634 | nucleus | IDA | 15548660 |
GO:0005737 | cytoplasm | IEA,IDA | 15548660 |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NOSIP Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | eNOS activation and regulation | ||
2 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
3 | Metabolism |
.37
|
Pathways by source for NOSIP Gene
4 Reactome pathways for NOSIP Gene
1 Qiagen pathway for NOSIP Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0016567 | protein ubiquitination | IBA,IEA | -- |
GO:0043086 | negative regulation of catalytic activity | IDA | 11149895 |
GO:0050999 | regulation of nitric-oxide synthase activity | TAS | -- |
GO:0051001 | negative regulation of nitric-oxide synthase activity | IDA | 11149895 |
No data available for SIGNOR curated interactions for NOSIP Gene
Transcripts for NOSIP Gene
mRNA/cDNA for NOSIP Gene
- (8) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (372) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NOSIP Gene
CRISPR Products
-
OriGene CRISPR knockouts for NOSIP
- genomics-online: gRNA clones - Search results for 146 available NOSIP gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOSIP
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 146 available NOSIP gene related products
- Overview of 146 available NOSIP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NOSIP gene
Clone Products
- Sino Biological Human cDNA Clone for NOSIP
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NOSIP
- Applied Biological Materials Clones for NOSIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - | - |
Expression for NOSIP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T-Cytotoxic Cells Peripheral Blood
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for NOSIP Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOSIP Gene
NURSA nuclear receptor signaling pathways regulating expression of NOSIP Gene:
NOSIPSOURCE GeneReport for Unigene cluster for NOSIP Gene:
Hs.7236mRNA Expression by UniProt/SwissProt for NOSIP Gene:
Q9Y314-NOSIP_HUMANEvidence on tissue expression from TISSUES for NOSIP Gene
- Nervous system(4.6)
- Liver(4.5)
- Lung(3)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for NOSIP
-
OriGene qPCR primer pairs and template standards for NOSIP
- genomics-online: primer clones - Search results for 146 available NOSIP gene related products
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOSIP Gene
Orthologs for NOSIP Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NOSIP 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | NOSIP 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | NOSIP 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nosip 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nosip 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | NOSIP 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | NOSIP 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nosip 33 |
|
||
MGC75989 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | nosip 33 34 |
|
||
-- 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG6179 35 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005654 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | R05G6.4 33 34 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G61620 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os03g0279900 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for NOSIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NOSIP Gene
No data available for Paralogs for NOSIP Gene
Variants for NOSIP Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000145770 | -- | 49,572,268(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
rs1000148676 | -- | 49,562,154(-) | T/C | intron_variant | |
rs1000256329 | -- | 49,566,342(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000273297 | -- | 49,567,254(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000332089 | -- | 49,580,610(-) | C/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1160655 | CNV | deletion | 26073780 |
nsv469715 | CNV | gain+loss | 16826518 |
nsv828578 | CNV | loss | 20364138 |
nsv833862 | CNV | loss | 17160897 |
nsv833863 | CNV | loss | 17160897 |
nsv833864 | CNV | gain | 17160897 |
nsv833865 | CNV | gain+loss | 17160897 |
nsv953600 | CNV | deletion | 24416366 |
nsv9739 | CNV | gain+loss | 18304495 |
Additional Variant Information for NOSIP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NOSIP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOSIP Gene
Disorders for NOSIP Gene
Additional Disease Information for NOSIP
No disorders were found for NOSIP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOSIP Gene
Publications for NOSIP Gene
- Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PMID: 16135813) Schleicher M … Oess S (Molecular and cellular biology 2005) 3 4 22 58
- NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PMID: 11149895) Dedio J … Müller-Esterl W (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001) 2 3 4 58
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. (PMID: 15548660) Dreyer J … Kuner R (The Journal of neuroscience : the official journal of the Society for Neuroscience 2004) 3 4 58
Products for NOSIP Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOSIP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NOSIP
- antibodies-online: Search results for 43 available NOSIP Antibodies ranked by validation data
- Compare Top NOSIP Antibodies
- antibodies-online: Search results for 8 available NOSIP Elisa Kits ranked by validation data
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- antibodies-online: Search results for 10 available NOSIP Proteins ranked by validation data
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- GeneTex NOSIP antibody for NOSIP
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- genomics-online: cdna clones - Search results for 146 available NOSIP gene related products
- Overview of 146 available NOSIP gene related products
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- Overview of 146 available NOSIP gene related products
- genomics-online: gRNA clones - Search results for 146 available NOSIP gene related products
- Overview of 146 available NOSIP gene related products
- genomics-online: primer clones - Search results for 146 available NOSIP gene related products
- Overview of 146 available NOSIP gene related products
- genomics-online: shRNA clones - Search results for 146 available NOSIP gene related products
- Overview of 146 available NOSIP gene related products
Sources for NOSIP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
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