Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NOSIP Gene

Aliases for NOSIP Gene

  • Nitric Oxide Synthase Interacting Protein 2 3
  • ENOS-Interacting Protein 3 4
  • Nitric Oxide Synthase-Interacting Protein 3
  • CGI-25 3

External Ids for NOSIP Gene

Previous GeneCards Identifiers for NOSIP Gene

  • GC19M050717
  • GC19M050427
  • GC19M054734
  • GC19M054751
  • GC19M054752
  • GC19M054753
  • GC19M050058
  • GC19M046436

Summaries for NOSIP Gene

Entrez Gene Summary for NOSIP Gene

  • The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]

GeneCards Summary for NOSIP Gene

NOSIP (Nitric Oxide Synthase Interacting Protein) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Metabolism.

UniProtKB/Swiss-Prot for NOSIP Gene

  • Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Gene Wiki entry for NOSIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOSIP Gene

Genomics for NOSIP Gene

Regulatory Elements for NOSIP Gene

Genomic Location for NOSIP Gene

49,555,468 bp from pter
49,590,262 bp from pter
34,795 bases
Minus strand

Genomic View for NOSIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOSIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOSIP Gene

Proteins for NOSIP Gene

  • Protein details for NOSIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nitric oxide synthase-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q96FD2

    Protein attributes for NOSIP Gene

    301 amino acids
    Molecular mass:
    33172 Da
    Quaternary structure:
    • Interacts with NOS1 and NOS3.

neXtProt entry for NOSIP Gene

Proteomics data for NOSIP Gene at MOPED

Post-translational modifications for NOSIP Gene

  • Ubiquitination at Lys117, Lys157, Lys253, and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for NOSIP Gene

Antibody Products

No data available for DME Specific Peptides for NOSIP Gene

Domains for NOSIP Gene

Protein Domains for NOSIP Gene

Suggested Antigen Peptide Sequences for NOSIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y314
  • The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not
  • Belongs to the NOSIP family.
genes like me logo Genes that share domains with NOSIP: view

No data available for Gene Families for NOSIP Gene

Function for NOSIP Gene

Molecular function for NOSIP Gene

UniProtKB/Swiss-Prot Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Gene Ontology (GO) - Molecular Function for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11149895
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOSIP: view

Phenotypes for NOSIP Gene

GenomeRNAi human phenotypes for NOSIP:
genes like me logo Genes that share phenotypes with NOSIP: view

Animal Model Products

CRISPR Products

miRNA for NOSIP Gene

miRTarBase miRNAs that target NOSIP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOSIP Gene

Localization for NOSIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOSIP Gene

Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.

Subcellular locations from

Jensen Localization Image for NOSIP Gene COMPARTMENTS Subcellular localization image for NOSIP gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 4
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15548660
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NOSIP: view

Pathways for NOSIP Gene

genes like me logo Genes that share pathways with NOSIP: view

Pathways by source for NOSIP Gene

PCR Array Products

Interacting Proteins for NOSIP Gene

Selected Interacting proteins: Q9Y314-NOSIP_HUMAN for NOSIP Gene via I2D

Gene Ontology (GO) - Biological Process for NOSIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IDA 11149895
GO:0044281 small molecule metabolic process TAS --
GO:0046209 nitric oxide metabolic process TAS --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
GO:0051001 negative regulation of nitric-oxide synthase activity IDA 11149895
genes like me logo Genes that share ontologies with NOSIP: view

Transcripts for NOSIP Gene

Unigene Clusters for NOSIP Gene

Nitric oxide synthase interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOSIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOSIP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP8: - - - -
SP9: -
SP10: - -

Relevant External Links for NOSIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOSIP Gene

mRNA expression in normal human tissues for NOSIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOSIP Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOSIP Gene

SOURCE GeneReport for Unigene cluster for NOSIP Gene Hs.7236

mRNA Expression by UniProt/SwissProt for NOSIP Gene

Tissue specificity: Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
genes like me logo Genes that share expressions with NOSIP: view

In Situ Assay Products

Orthologs for NOSIP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOSIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOSIP 35
  • 98.89 (n)
  • 99 (a)
  • 100 (a)
(Bos Taurus)
Mammalia NOSIP 35
  • 91.03 (n)
  • 94.68 (a)
  • 94 (a)
(Canis familiaris)
Mammalia NOSIP 35
  • 88.26 (n)
  • 92.69 (a)
  • 67 (a)
(Mus musculus)
Mammalia Nosip 35
  • 85.83 (n)
  • 90.7 (a)
Nosip 16
Nosip 36
  • 91 (a)
(Monodelphis domestica)
Mammalia NOSIP 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
-- 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Nosip 35
  • 85.94 (n)
  • 91.69 (a)
(Anolis carolinensis)
Reptilia NOSIP 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75989 35
nosip 35
  • 65.88 (n)
  • 72.82 (a)
(Danio rerio)
Actinopterygii -- 35
nosip 35
  • 63.41 (n)
  • 68.01 (a)
nosip 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005654 35
  • 58.97 (n)
  • 54.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6179 35
  • 59.8 (n)
  • 53.04 (a)
CG6179 36
  • 47 (a)
CG6179 37
  • 48 (a)
(Caenorhabditis elegans)
Secernentea R05G6.4 35
  • 48.51 (n)
  • 48.28 (a)
R05G6.4 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61620 35
  • 44.29 (n)
  • 33.57 (a)
(Oryza sativa)
Liliopsida Os03g0279900 35
  • 46.16 (n)
  • 33.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for NOSIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOSIP Gene

Gene Tree for NOSIP (if available)
Gene Tree for NOSIP (if available)

Paralogs for NOSIP Gene

No data available for Paralogs for NOSIP Gene

Variants for NOSIP Gene

Sequence variations from dbSNP and Humsavar for NOSIP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2379086 -- 49,574,615(+) aggct(G/T)gaagt intron-variant
rs2379087 -- 49,575,019(+) CACCA(C/T)GCCCG intron-variant
rs4316869 -- 49,571,900(+) gaatc(C/G)cttga intron-variant
rs4426453 -- 49,559,223(+) ttgag(C/T)ttcca intron-variant
rs4594362 -- 49,556,725(+) CAGGT(C/G)ACCGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for NOSIP Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv833862 CNV Loss 17160897
nsv912265 CNV Loss 21882294
nsv833863 CNV Loss 17160897
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897

Relevant External Links for NOSIP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOSIP Gene

Disorders for NOSIP Gene

No disorders were found for NOSIP Gene.

No data available for UniProtKB/Swiss-Prot for NOSIP Gene

Publications for NOSIP Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PMID: 11149895) Dedio J. … Mueller-Esterl W. (FASEB J. 2001) 2 3 4
  3. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PMID: 16135813) Schleicher M. … Oess S. (Mol. Cell. Biol. 2005) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. (PMID: 15548660) Dreyer J. … Kuner R. (J. Neurosci. 2004) 3 4

Products for NOSIP Gene

Sources for NOSIP Gene

Back to Top