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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOSIP Gene

protein-coding   GIFtS: 55
GCID: GC19M050058

Nitric Oxide Synthase Interacting Protein
  See related diseases
at
MalaCards
 

Aliases
for NOSIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Nitric Oxide Synthase Interacting Protein1 2
ENOS-Interacting Protein2 3
Nitric Oxide Synthase-Interacting Protein2

External Ids:    HGNC: 179461   Entrez Gene: 510702   Ensembl: ENSG000001425467   UniProtKB: Q9Y3143   

Export aliases for NOSIP gene to outside databases

Previous GC identifers: GC19M050717 GC19M050427 GC19M054734 GC19M054751 GC19M054752 GC19M054753 GC19M046436


Summaries
for NOSIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NOSIP Gene:
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial
and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that
encode the same protein. (provided by RefSeq, Aug 2012)

GeneCards Summary for NOSIP Gene: 
NOSIP (nitric oxide synthase interacting protein) is a protein-coding gene. Diseases associated with NOSIP include alcoholic hepatitis, and endotheliitis, and among its related super-pathways are Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin
cytoskeleton and inhibiting their enzymatic activity

Gene Wiki entry for NOSIP Gene


Genomic Views
for NOSIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOSIP gene promoter:
         p53   STAT5A   RelA   NF-kappaB   Egr-4   Egr-2   HOXA5   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOSIP promoter sequence
   Search SABiosciences Chromatin IP Primers for NOSIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOSIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

NOSIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOSIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050058:  view genomic region     (about GC identifiers)

Start:
 50,058,968 bp from pter      End:
 50,093,519 bp from pter
Size:
 34,552 bases      Orientation:
 minus strand

Proteins
for NOSIP gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314 (See protein sequence)
Recommended Name: Nitric oxide synthase-interacting protein  
Size: 301 amino acids; 33172 Da
Subunit: Interacts with NOS1 and NOS3
Subcellular location: Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell
cycle
Secondary accessions: Q96FD2

Explore the universe of human proteins at neXtProt for NOSIP: NX_Q9Y314

Explore proteomics data for NOSIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y314

    • NOSIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOSIP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257889.1  NP_057037.1  

    ENSEMBL proteins: 
     ENSP00000470450   ENSP00000343497   ENSP00000470034   ENSP00000473109   ENSP00000471929  
     ENSP00000472103   ENSP00000471291   ENSP00000468974   ENSP00000375726  
    Reactome Protein details: Q9Y314
    Human Recombinant Protein Products for NOSIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NOSIP
    OriGene Protein Over-expression Lysate for NOSIP
    OriGene MassSpec for NOSIP 
    OriGene Custom Protein Services for NOSIP
    GenScript Custom Purified and Recombinant Proteins Services for NOSIP
    Novus Biologicals NOSIP Protein
    Novus Biologicals NOSIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOSIP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA15548660
    GO:0005829cytosol TAS--

    NOSIP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NOSIP gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR016818 Nitric_oxide_synth-interacting

    Graphical View of Domain Structure for InterPro Entry Q9Y314

    ProtoNet protein and cluster: Q9Y314

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
    Domain: The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not
    Similarity: Belongs to the NOSIP family


    NOSIP for domains           About GeneDecksing


    Function
    for NOSIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOSIP_HUMAN, Q9Y314
    Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin
    cytoskeleton and inhibiting their enzymatic activity

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11149895
         
    NOSIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOSIP:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOSIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOSIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOSIP 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of NOSIP 

    Cell Line
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    Search LifeMap BioReagents cell lines for NOSIP
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP


    Pathways & Interactions
    for NOSIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOSIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of nitric oxide
    		Metabolism of nitric oxide0.59
    		eNOS activation and regulation0.59
    2Nanog in Mammalian ESC Pluripotency
    		eNOS Signaling0.48
    3Metabolism
    		Metabolism0.40
    4NOSIP mediated eNOS trafficking
    		NOSIP mediated eNOS trafficking

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NOSIP
        eNOS Signaling


    4        Reactome Pathways for NOSIP
        eNOS activation and regulation
    Metabolism of nitric oxide
    Metabolism
    NOSIP mediated eNOS trafficking



    NOSIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOSIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for NOSIP (Q9Y3143 ENSP000003434974) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    EPORP192353, ENSP000002221394I2D: score=1 STRING: ENSP00000222139
    NOS3P294743, ENSP000002974944I2D: score=1 STRING: ENSP00000297494
    BCAR3O758153, ENSP000002605024I2D: score=1 STRING: ENSP00000260502
    LMLNQ96KR43I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043086negative regulation of catalytic activity IDA11149895
    GO:0044281small molecule metabolic process TAS--
    GO:0046209nitric oxide metabolic process TAS--
    GO:0050999regulation of nitric-oxide synthase activity TAS--
    GO:0051001negative regulation of nitric-oxide synthase activity IDA11149895

    NOSIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOSIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOSIP

    Search CenterWatch for drugs/clinical trials and news about NOSIP

    Transcripts
    for NOSIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOSIP gene (2 alternative transcripts): 
    NM_001270960.1  NM_015953.4  

    Unigene Cluster for NOSIP:

    Nitric oxide synthase interacting protein
    Hs.7236  [show with all ESTs]
    Unigene Representative Sequence: BC047314
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601015 ENST00000598820 ENST00000339093(uc002pol.3 uc010yay.1)
    ENST00000596358 ENST00000601340 ENST00000596477 ENST00000598550 ENST00000599537
    ENST00000598296 ENST00000594932 ENST00000600019 ENST00000598544 ENST00000599425
    ENST00000598839 ENST00000601107 ENST00000593345 ENST00000391853(uc002pok.3)

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NOSIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOSIP
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    OriGene ORF clones in mouse, rat for NOSIP
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSIP
    Sirion Biotech Customized lentivirus for stable overexpression of NOSIP 
                         Customized lentivirus expression plasmids for stable overexpression of NOSIP 
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    OriGene qSTAR qPCR primer pairs in human, mouse for NOSIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOSIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOSIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOSIP

    Additional mRNA sequence: 

    AF132959.1 AK092444.1 AK291535.1 AK300720.1 BC009299.2 BC010077.2 BC011249.1 BC047314.1 

    19 DOTS entries:

    DT.99975462  DT.452105  DT.101984796  DT.87001719  DT.95261373  DT.40196975  DT.91770602  DT.91770604 
    DT.91770607  DT.95261374  DT.100733542  DT.100825128  DT.102841623  DT.121408966  DT.95084180  DT.95327946 
    DT.97817414  DT.97849044  DT.100808047 

    24/372 AceView cDNA sequences (see all 372):

    AA147395 CB128803 BM995776 BM808037 BP372940 BM996788 BE782091 CA454253 
    BU556759 BM015960 BM694449 CF127048 CB109602 BM919394 AI148730 AA320721 
    BE743958 AI344201 BM558738 BU526794 CB126120 BM793482 BE560941 BC010077 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NOSIP (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -           -                 -     -     -                 -                                       
    SP2:              -           -           -                 -     -     -                 -                                       
    SP3:                          -           -                 -     -     -                                                         
    SP4:              -           -           -                                               -                                       
    SP5:              -           -           -                 -     -     -                                                         


    ECgene alternative splicing isoforms for NOSIP

    Expression
    for NOSIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOSIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGACCCTG
    NOSIP Expression
    About this image


    See NOSIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOSIP

    SOURCE GeneReport for Unigene cluster: Hs.7236

    UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
    Tissue specificity: Expressed in heart, brain and lung. Present in endothelial cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOSIP: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP

    Orthologs
    for NOSIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOSIP gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nosip1 , 5 nitric oxide synthase interacting protein1, 5 85.83(n)1
    90.7(a)1    		   7 (29.10 cM)5
    663941  NM_025533.31  NP_079809.11 
     450624295 
    lizard
    (Anolis carolinensis)    		 Reptilia NOSIP6
    		 Uncharacterized protein
    		 77(a)
    		 1 ↔ 1
    		 6(80453902-80464707)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA974674.12   -- 75.03(n)    CA974674.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570433912   -- 79.03(n)   323049  57043391 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG61791 , 3 CG61791 48(a)3
    60.02(n)1
    53.04(a)1    		   17A93
    328191  NM_133060.21  NP_573288.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea R05G6.41 Protein R05G6.4 48.39(n)
    48.28(a)    		   177526  NM_068813.5  NP_501214.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G616201 nitric oxide synthase-interacting protein 44.56(n)
    34.05(a)    		   842458  NM_104844.2  NP_564781.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g02799001 hypothetical protein 46.16(n)
    33.45(a)    		   4332437  NM_001056270.1  NP_001049735.1 


    ENSEMBL Gene Tree for NOSIP (if available)
    TreeFam Gene Tree for NOSIP (if available)

    Paralogs
    for NOSIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NOSIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/509 SNPs in NOSIP are shown (see all 509)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1500462631,2
    		--50058276(+) GCTGCC/GCACTT 2 -- ds50010--------
    rs771642621,2
    		C--50058337(+) AGACAC/TGTTCC 2 -- ds50010--------
    rs1395305821,2
    		C--50058339(+) ACACGC/TTCCTG 2 -- ds50010--------
    rs1178071161,2
    		F--50058430(+) AGTGGC/TGCACT 2 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1848490641,2
    		--50058441(+) CACACA/GGTCTT 2 -- ds50010--------
    rs1475587941,2
    		--50058601(+) ACCTCA/CGCCTC 2 -- ds50010--------
    rs1133427141,2
    		C,F--50058721(+) ATGTTA/GGCCAG 2 -- ds50011Minor allele frequency- G:0.33CSA 3
    rs1883739961,2
    		C--50058742(+) AACTCC/TTGACC 2 -- ut310--------
    rs1931593481,2
    		--50058782(+) AAGTGC/TTGGGA 2 -- ut310--------
    rs1845966781,2
    		--50058859(+) TAGCCC/GGCTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NOSIP (50058968 - 50093519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NOSIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912262CNV Loss21882294
    nsv912261CNV Loss21882294
    nsv912265CNV Loss21882294
    nsv833862CNV Loss17160897
    nsv833863CNV Loss17160897
    nsv828578CNV Loss20364138
    nsv833864CNV Gain17160897
    nsv9739CNV Gain+Loss18304495
    nsv833865CNV Gain+Loss17160897
    nsv469715CNV Complex16826518

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    Disorders / Diseases
    for NOSIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 6 diseases for NOSIP:    About MalaCards
    alcoholic hepatitis    endotheliitis    alcoholism    hypertension
    neuronitis    hepatitis


    NOSIP for disorders           About GeneDecksing


    Export disorders for NOSIP gene to outside databases

    Publications
    for NOSIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOSIP gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with NOSIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PubMed id 11149895)1, 2, 3 Dedio J....Mueller-Esterl W. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PubMed id 16135813)1, 2, 9 Schleicher M.... Oess S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. (PubMed id 15548660)1, 2 Dreyer J.... Kuner R. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for NOSIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOSIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51070 HGNC: 17946 AceView: NOSIP Ensembl:ENSG00000142546 euGenes: HUgn51070
    ECgene: NOSIP H-InvDB: NOSIP

    Other Databases showing NOSIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOSIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOSIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NOSIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOSIP gene:
    Search GeneIP for patents involving NOSIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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