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NOSIP Gene

protein-coding GIFtS: 58
GCID: GC19M050058

Nitric Oxide Synthase Interacting Protein

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nitric Oxide Synthase Interacting Protein¹ ²
ENOS-Interacting Protein² ³
Nitric Oxide Synthase-Interacting Protein²

External Ids:	HGNC: 17946¹	Entrez Gene: 51070²	Ensembl: ENSG00000142546⁷	UniProtKB: Q9Y314³

ORGUL members:

Export aliases for NOSIP gene to outside databases

Previous GC identifers: GC19M050717 GC19M050427 GC19M054734 GC19M054751 GC19M054752 GC19M054753 GC19M046436

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOSIP Gene:

The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial

and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that

encode the same protein. (provided by RefSeq, Aug 2012)

GeneCards Summary for NOSIP Gene:

NOSIP (nitric oxide synthase interacting protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314

Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin

cytoskeleton and inhibiting their enzymatic activity

Gene Wiki entry for NOSIP Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9 NT_011109.17 NC_018930.2

Regulatory elements:

Regulatory transcription factor binding sites in the NOSIP gene promoter:
p53 STAT5A RelA NF-kappaB Egr-4 Egr-2 HOXA5 c-Myb Zic3 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOSIP promoter sequence

Search Chromatin IP Primers for NOSIP

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOSIP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3

NOSIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOSIP gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M050058: view genomic region (about GC identifiers)

Start:	50,058,968 bp from pter	End:	50,093,519 bp from pter
Size:	34,552 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314 (See protein sequence)

Recommended Name: Nitric oxide synthase-interacting protein

Size: 301 amino acids; 33172 Da

Subunit: Interacts with NOS1 and NOS3

Secondary accessions: Q96FD2

Explore the universe of human proteins at neXtProt for NOSIP: NX_Q9Y314

Explore proteomics data for NOSIP at MOPED

Post-translational modifications:

Ubiquitination² at Lys117, Lys157, Lys253, Lys294

Modification sites at PhosphoSitePlus

See NOSIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001257889.1 NP_057037.1

ENSEMBL proteins:

ENSP00000470450 ENSP00000343497 ENSP00000470034 ENSP00000473109 ENSP00000471929

ENSP00000472103 ENSP00000471291 ENSP00000468974 ENSP00000375726

Reactome Protein details: Q9Y314

NOSIP Human Recombinant Protein Products:

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	OriGene Purified Protein for NOSIP OriGene Protein Over-expression Lysate for NOSIP OriGene MassSpec for NOSIP OriGene Custom Protein Services for NOSIP
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	Novus Biologicals NOSIP Protein Novus Biologicals NOSIP Lysates
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	Cloud-Clone Corp. Proteins for NOSIP
	Search eBioscience for Proteins for NOSIP
	antibodies-online proteins for NOSIP (8 products)
	antibodies-online peptides for NOSIP

NOSIP Antibody Products:

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	antibodies-online antibodies for NOSIP (22 products)

NOSIP Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NOSIP Cloud-Clone Corp. CLIAs for NOSIP
	Search eBioscience for ELISAs for NOSIP
	antibodies-online kits for NOSIP (8 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR016818 Nitric_oxide_synth-interacting

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q9Y314

ProtoNet protein and cluster: Q9Y314

1 Blocks protein domain: IPB003613 Zn-finger

UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314

Domain: The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not

Similarity: Belongs to the NOSIP family

Find genes that share domains with NOSIP About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NOSIP_HUMAN, Q9Y314

Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin

cytoskeleton and inhibiting their enzymatic activity

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11149895
GO:0044822	poly(A) RNA binding	IDA	--

Find genes that share ontologies with NOSIP About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for NOSIP:

Increased cell number in S and

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for NOSIP

miRNA Products:		miRTarBase miRNAs that target NOSIP: hsa-mir-124-3p (MIRT022321), hsa-mir-193b-3p (MIRT016289)

		Block miRNA regulation of human, mouse, rat NOSIP using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate NOSIP
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOSIP
		Predesigned siRNA for gene silencing in human, mouse, rat NOSIP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NOSIP

Clone Products:		OriGene clones in human, mouse for NOSIP (see all 8) OriGene ORF clones in mouse, rat for NOSIP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOSIP (NM_015953)
		Sino Biological Human cDNA Clone for NOSIP
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSIP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOSIP
		Browse ESI BIO Cell Lines and PureStem Progenitors for NOSIP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NOSIP_HUMAN, Q9Y314: Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell

cycle

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	4
golgi apparatus	4
extracellular	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	15548660
GO:0005829	cytosol	TAS	--

Find genes that share ontologies with NOSIP About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NOSIP About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Metabolism of nitric oxide

	Metabolism of nitric oxide			eNOS activation and regulation	0.00
	NOSIP mediated eNOS trafficking	0.00

Nanog in Mammalian ESC Pluripotency

eNOS Signaling

0.48

Metabolism

Metabolism

0.38

Find genes that share SuperPaths with NOSIP About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NOSIP

eNOS Signaling

1 Reactome Pathway for NOSIP

NOSIP mediated eNOS trafficking

Pathway & Disease-focused RT² Profiler PCR Arrays including NOSIP:

Hypertension in human mouse rat

Neurotoxicity in human mouse rat

Ubiquitin Ligases in human mouse rat

Interactions:

GeneGlobe Interaction Network for NOSIP

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for NOSIP (Q9Y314³ ENSP00000343497⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOS1	P29475³, ENSP00000320758⁴	I2D: score=1 STRING: ENSP00000320758
EPOR	P19235³, ENSP00000222139⁴	I2D: score=1 STRING: ENSP00000222139
NOS3	P29474³, ENSP00000297494⁴	I2D: score=1 STRING: ENSP00000297494
BCAR3	O75815³, ENSP00000260502⁴	I2D: score=1 STRING: ENSP00000260502
LMLN	Q96KR4³	I2D: score=5

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043086	negative regulation of catalytic activity	IDA	11149895
GO:0044281	small molecule metabolic process	TAS	--
GO:0046209	nitric oxide metabolic process	TAS	--
GO:0050999	regulation of nitric-oxide synthase activity	TAS	--
GO:0051001	negative regulation of nitric-oxide synthase activity	IDA	11149895

Find genes that share ontologies with NOSIP About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NOSIP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NOSIP gene (2 alternative transcripts):

NM_001270960.1 NM_015953.4

Unigene Cluster for NOSIP:

Nitric oxide synthase interacting protein

Hs.7236 [show with all ESTs]

Unigene Representative Sequence: BC047314

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000601015 ENST00000598820 ENST00000339093(uc002pol.3 uc010yay.1)

ENST00000596358 ENST00000601340 ENST00000596477 ENST00000598550 ENST00000599537

ENST00000598296 ENST00000594932 ENST00000600019 ENST00000598544 ENST00000599425

ENST00000598839 ENST00000601107 ENST00000593345 ENST00000391853(uc002pok.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat NOSIP using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate NOSIP
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOSIP
		Predesigned siRNA for gene silencing in human, mouse, rat NOSIP

Clone Products:		OriGene clones in human, mouse for NOSIP (see all 8) OriGene ORF clones in mouse, rat for NOSIP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOSIP (NM_015953)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSIP

Primer Products:		OriGene qPCR primer pairs and template standards for NOSIP OriGene qSTAR qPCR primer pairs in human, mouse for NOSIP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NOSIP
		QuantiTect SYBR Green Assays in human, mouse, rat NOSIP
		QuantiFast Probe-based Assays in human, mouse, rat NOSIP

Additional mRNA sequence:

AF132959.1 AK092444.1 AK291535.1 AK300720.1 BC009299.2 BC010077.2 BC011249.1 BC047314.1

19 DOTS entries:

DT.99975462 DT.452105 DT.101984796 DT.87001719 DT.95261373 DT.40196975 DT.91770602 DT.91770604

DT.91770607 DT.95261374 DT.100733542 DT.100825128 DT.102841623 DT.121408966 DT.95084180 DT.95327946

DT.97817414 DT.97849044 DT.100808047

Selected AceView cDNA sequences (see all 372):

CD723857 AU100192 AA335854 BE903059 BE252367 AI313481 BE792189 CB109602

CB147488 BM996788 BM981688 BQ647931 BI759415 BP372940 BM904048 BM560019

BQ686718 AA147395 CB128803 BM015960 BM708019 BM694708 BE743958 BE778275

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOSIP (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12a	·	12b
SP1:									-				-						-		-		-						-
SP2:					-				-				-						-		-		-						-
SP3:									-				-						-		-		-
SP4:					-				-				-																-
SP5:					-				-				-						-		-		-

ECgene alternative splicing isoforms for NOSIP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NOSIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGACCCTG

About this image

NOSIP expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Blood (Hematopoietic System) fully expand to see all 2 entries
T-Cytotoxic Cells Peripheral Blood

Testis (Reproductive System)

NOSIP Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NOSIP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.7236

UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314

Tissue specificity: Expressed in heart, brain and lung. Present in endothelial cells (at protein level)

Pathway & Disease-focused RT² Profiler PCR Arrays including NOSIP:

Hypertension in human mouse rat

Neurotoxicity in human mouse rat

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for NOSIP OriGene qSTAR qPCR primer pairs in human, mouse for NOSIP
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NOSIP
		QuantiTect SYBR Green Assays in human, mouse, rat NOSIP
		QuantiFast Probe-based Assays in human, mouse, rat NOSIP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for NOSIP gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nosip^{1 , 5}	nitric oxide synthase interacting protein^{1, 5}	85.83(n)¹ 90.7(a)¹		7 (29.10 cM)⁵ 66394¹ NM_025533.3¹ NP_079809.1¹ 45062429⁵
lizard (Anolis carolinensis)	Reptilia	NOSIP⁶	nitric oxide synthase interacting protein	78(a)	1 ↔ 1	6(80453902-80464707)
African clawed frog (Xenopus laevis)	Amphibia	CA974674.1²	--	75.03(n)		CA974674.1
zebrafish (Danio rerio)	Actinopterygii	57043391²	--	79.03(n)		323049 57043391
fruit fly (Drosophila melanogaster)	Insecta	CG6179^{1 , 3}	CG6179¹	48(a)³ 59.8(n)¹ 53.04(a)¹		17A9³ 32819¹ NM_133060.3¹ NP_573288.1¹
worm (Caenorhabditis elegans)	Secernentea	R05G6.4¹	R05G6.4	48.51(n) 48.28(a)		177526 NM_068813.6 NP_501214.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G61620¹	AT1G61620	44.29(n) 33.57(a)		842458 NM_104844.2 NP_564781.1
rice (Oryza sativa)	Liliopsida	Os03g0279900¹	Os03g0279900	46.16(n) 33.45(a)		4332437 NM_001056270.1 NP_001049735.1

ENSEMBL Gene Tree for NOSIP (if available)
TreeFam Gene Tree for NOSIP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150046263^1,2		--	50058276(+)	`GCTGCC/GCACTT`	2	--	ds500¹		0	--	--	--	--
rs77164262^1,2	C	--	50058337(+)	`AGACAC/TGTTCC`	2	--	ds500¹		0	--	--	--	--
rs139530582^1,2	C	--	50058339(+)	`ACACGC/TTCCTG`	2	--	ds500¹		0	--	--	--	--
rs117807116^1,2	F	--	50058430(+)	`AGTGGC/TGCACT`	2	--	ds500¹		1		EA	120
rs184849064^1,2		--	50058441(+)	`CACACA/GGTCTT`	2	--	ds500¹		0	--	--	--	--
rs147558794^1,2		--	50058601(+)	`ACCTCA/CGCCTC`	2	--	ds500¹		0	--	--	--	--
rs113342714^1,2	C,F	--	50058721(+)	`ATGTTA/GGCCAG`	2	--	ds500¹		1		CSA	3
rs188373996^1,2	C	--	50058742(+)	`AACTCC/TTGACC`	2	--	ut3¹		0	--	--	--	--
rs193159348^1,2		--	50058782(+)	`AAGTGC/TTGGGA`	2	--	ut3¹		0	--	--	--	--
rs184596678^1,2		--	50058859(+)	`TAGCCC/GGCTCT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NOSIP (50058968 - 50093519 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for NOSIP: About this table

Variant ID	Type	Subtype	PubMed ID
nsv912262	CNV	Loss	21882294
nsv912261	CNV	Loss	21882294
nsv912265	CNV	Loss	21882294
nsv833862	CNV	Loss	17160897
nsv833863	CNV	Loss	17160897
nsv828578	CNV	Loss	20364138
nsv833864	CNV	Gain	17160897
nsv9739	CNV	Gain+Loss	18304495
nsv833865	CNV	Gain+Loss	17160897
nsv469715	CNV	Complex	16826518

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NOSIP

DNA2.0 Custom Variant and Variant Library Synthesis for NOSIP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NOSIP gene, integrated from 10 sources (see all 29):
(articles sorted by number of sources associating them with NOSIP)

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NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PubMed id 11149895)^{1, 2, 3} Dedio J....Mueller-Esterl W. (FASEB J. 2001)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2, 3} Lai C.-H.... Lin W.-C. (Genome Res. 2000)
Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PubMed id 16135813)^{1, 2, 9} Schleicher M.... Oess S. (Mol. Cell. Biol. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. (PubMed id 15548660)^{1, 2} Dreyer J.... Kuner R. (J. Neurosci. 2004)
The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)¹ Lu L....Zhang L. (J. Biol. Chem. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51070	HGNC: 17946	AceView: NOSIP	Ensembl:ENSG00000142546	euGenes: HUgn51070
ECgene: NOSIP	H-InvDB: NOSIP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NOSIP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NOSIP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NOSIP gene:
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Nitric Oxide Synthase Interacting Protein

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