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NOSIP Gene

protein-coding   GIFtS: 58
GCID: GC19M050058

Nitric Oxide Synthase Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nitric Oxide Synthase Interacting Protein1 2
ENOS-Interacting Protein2 3
Nitric Oxide Synthase-Interacting Protein2

External Ids:    HGNC: 179461   Entrez Gene: 510702   Ensembl: ENSG000001425467   UniProtKB: Q9Y3143   
ORGUL members:         

Export aliases for NOSIP gene to outside databases

Previous GC identifers: GC19M050717 GC19M050427 GC19M054734 GC19M054751 GC19M054752 GC19M054753 GC19M046436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOSIP Gene:
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial
and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that
encode the same protein. (provided by RefSeq, Aug 2012)

GeneCards Summary for NOSIP Gene:
NOSIP (nitric oxide synthase interacting protein) is a protein-coding gene. Diseases associated with NOSIP include alcoholic hepatitis, and endotheliitis.

UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin
cytoskeleton and inhibiting their enzymatic activity

Gene Wiki entry for NOSIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOSIP gene promoter:
         p53   STAT5A   RelA   NF-kappaB   Egr-4   Egr-2   HOXA5   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOSIP promoter sequence
   Search Chromatin IP Primers for NOSIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOSIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

NOSIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOSIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050058:  view genomic region     (about GC identifiers)

Start:
50,058,968 bp from pter      End:
50,093,519 bp from pter
Size:
34,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314 (See protein sequence)
Recommended Name: Nitric oxide synthase-interacting protein  
Size: 301 amino acids; 33172 Da
Subunit: Interacts with NOS1 and NOS3
Secondary accessions: Q96FD2

Explore the universe of human proteins at neXtProt for NOSIP: NX_Q9Y314

Explore proteomics data for NOSIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys117, Lys157, Lys253, Lys294
  • Modification sites at PhosphoSitePlus

  • See NOSIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257889.1  NP_057037.1  

    ENSEMBL proteins: 
     ENSP00000470450   ENSP00000343497   ENSP00000470034   ENSP00000473109   ENSP00000471929  
     ENSP00000472103   ENSP00000471291   ENSP00000468974   ENSP00000375726  
    Reactome Protein details: Q9Y314

    NOSIP Human Recombinant Protein Products:

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    Novus Biologicals NOSIP Protein
    Novus Biologicals NOSIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NOSIP

    NOSIP Antibody Products:

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    NOSIP Assay Products:

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    Cloud-Clone Corp. ELISAs for NOSIP
    Cloud-Clone Corp. CLIAs for NOSIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016818 Nitric_oxide_synth-interacting
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y314

    ProtoNet protein and cluster: Q9Y314

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
    Domain: The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not
    Similarity: Belongs to the NOSIP family


    NOSIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOSIP_HUMAN, Q9Y314
    Function: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin
    cytoskeleton and inhibiting their enzymatic activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11149895
    GO:0044822poly(A) RNA binding IDA--
         
    NOSIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOSIP:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOSIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOSIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOSIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOSIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOSIP:
    hsa-mir-124-3p (MIRT022321), hsa-mir-193b-3p (MIRT016289)

    Block miRNA regulation of human, mouse, rat NOSIP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NOSIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NOSIP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NOSIP

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    OriGene clones in human, mouse for NOSIP (see all 8)
    OriGene ORF clones in mouse, rat for NOSIP
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    GenScript: all cDNA clones in your preferred vector: NOSIP (NM_015953)
    Sino Biological Human cDNA Clone for NOSIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSIP

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOSIP_HUMAN, Q9Y314: Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell
    cycle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus4
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA15548660
    GO:0005829cytosol TAS--

    NOSIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOSIP About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of nitric oxide
    Metabolism of nitric oxide
    eNOS activation and regulation0.00
    NOSIP mediated eNOS trafficking0.00
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NOSIP
        eNOS Signaling


    1 Reactome Pathway for NOSIP
        NOSIP mediated eNOS trafficking



    NOSIP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOSIP: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOSIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NOSIP (Q9Y3143 ENSP000003434974) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    EPORP192353, ENSP000002221394I2D: score=1 STRING: ENSP00000222139
    NOS3P294743, ENSP000002974944I2D: score=1 STRING: ENSP00000297494
    BCAR3O758153, ENSP000002605024I2D: score=1 STRING: ENSP00000260502
    LMLNQ96KR43I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043086negative regulation of catalytic activity IDA11149895
    GO:0044281small molecule metabolic process TAS--
    GO:0046209nitric oxide metabolic process TAS--
    GO:0050999regulation of nitric-oxide synthase activity TAS--
    GO:0051001negative regulation of nitric-oxide synthase activity IDA11149895

    NOSIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOSIP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOSIP gene (2 alternative transcripts): 
    NM_001270960.1  NM_015953.4  

    Unigene Cluster for NOSIP:

    Nitric oxide synthase interacting protein
    Hs.7236  [show with all ESTs]
    Unigene Representative Sequence: BC047314
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601015 ENST00000598820 ENST00000339093(uc002pol.3 uc010yay.1)
    ENST00000596358 ENST00000601340 ENST00000596477 ENST00000598550 ENST00000599537
    ENST00000598296 ENST00000594932 ENST00000600019 ENST00000598544 ENST00000599425
    ENST00000598839 ENST00000601107 ENST00000593345 ENST00000391853(uc002pok.3)

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOSIP
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOSIP (NM_015953)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOSIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOSIP
    Primer
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    OriGene qPCR primer pairs and template standards for NOSIP
    OriGene qSTAR qPCR primer pairs in human, mouse for NOSIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOSIP
      QuantiTect SYBR Green Assays in human, mouse, rat NOSIP
      QuantiFast Probe-based Assays in human, mouse, rat NOSIP

    Additional mRNA sequence: 

    AF132959.1 AK092444.1 AK291535.1 AK300720.1 BC009299.2 BC010077.2 BC011249.1 BC047314.1 

    19 DOTS entries:

    DT.99975462  DT.452105  DT.101984796  DT.87001719  DT.95261373  DT.40196975  DT.91770602  DT.91770604 
    DT.91770607  DT.95261374  DT.100733542  DT.100825128  DT.102841623  DT.121408966  DT.95084180  DT.95327946 
    DT.97817414  DT.97849044  DT.100808047 

    Selected AceView cDNA sequences (see all 372):

    CD723857 AU100192 AA335854 BE903059 BE252367 AI313481 BE792189 CB109602 
    CB147488 BM996788 BM981688 BQ647931 BI759415 BP372940 BM904048 BM560019 
    BQ686718 AA147395 CB128803 BM015960 BM708019 BM694708 BE743958 BE778275 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOSIP (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -           -                 -     -     -                 -                                       
    SP2:              -           -           -                 -     -     -                 -                                       
    SP3:                          -           -                 -     -     -                                                         
    SP4:              -           -           -                                               -                                       
    SP5:              -           -           -                 -     -     -                                                         


    ECgene alternative splicing isoforms for NOSIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOSIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGACCCTG
    NOSIP Expression
    About this image


    NOSIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Testis (Reproductive System)
    NOSIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOSIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7236

    UniProtKB/Swiss-Prot: NOSIP_HUMAN, Q9Y314
    Tissue specificity: Expressed in heart, brain and lung. Present in endothelial cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOSIP: 
              Hypertension in human mouse rat
              Neurotoxicity in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOSIP
    OriGene qSTAR qPCR primer pairs in human, mouse for NOSIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOSIP
    QuantiTect SYBR Green Assays in human, mouse, rat NOSIP
    QuantiFast Probe-based Assays in human, mouse, rat NOSIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOSIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOSIP gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nosip1 , 5 nitric oxide synthase interacting protein1, 5 85.83(n)1
    90.7(a)1
      7 (29.10 cM)5
    663941  NM_025533.31  NP_079809.11 
     450624295 
    lizard
    (Anolis carolinensis)
    Reptilia NOSIP6
    nitric oxide synthase interacting protein
    78(a)
    1 ↔ 1
    6(80453902-80464707)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA974674.12   -- 75.03(n)    CA974674.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570433912   -- 79.03(n)   323049  57043391 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61791 , 3 CG61791 48(a)3
    59.8(n)1
    53.04(a)1
      17A93
    328191  NM_133060.31  NP_573288.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R05G6.41 R05G6.4 48.51(n)
    48.28(a)
      177526  NM_068813.6  NP_501214.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G616201 AT1G61620 44.29(n)
    33.57(a)
      842458  NM_104844.2  NP_564781.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02799001 Os03g0279900 46.16(n)
    33.45(a)
      4332437  NM_001056270.1  NP_001049735.1 


    ENSEMBL Gene Tree for NOSIP (if available)
    TreeFam Gene Tree for NOSIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOSIP (see all 509)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500462631,2
    --50058276(+) GCTGCC/GCACTT 2 -- ds50010--------
    rs771642621,2
    C--50058337(+) AGACAC/TGTTCC 2 -- ds50010--------
    rs1395305821,2
    C--50058339(+) ACACGC/TTCCTG 2 -- ds50010--------
    rs1178071161,2
    F--50058430(+) AGTGGC/TGCACT 2 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1848490641,2
    --50058441(+) CACACA/GGTCTT 2 -- ds50010--------
    rs1475587941,2
    --50058601(+) ACCTCA/CGCCTC 2 -- ds50010--------
    rs1133427141,2
    C,F--50058721(+) ATGTTA/GGCCAG 2 -- ds50011Minor allele frequency- G:0.33CSA 3
    rs1883739961,2
    C--50058742(+) AACTCC/TTGACC 2 -- ut310--------
    rs1931593481,2
    --50058782(+) AAGTGC/TTGGGA 2 -- ut310--------
    rs1845966781,2
    --50058859(+) TAGCCC/GGCTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NOSIP (50058968 - 50093519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NOSIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912262CNV Loss21882294
    nsv912261CNV Loss21882294
    nsv912265CNV Loss21882294
    nsv833862CNV Loss17160897
    nsv833863CNV Loss17160897
    nsv828578CNV Loss20364138
    nsv833864CNV Gain17160897
    nsv9739CNV Gain+Loss18304495
    nsv833865CNV Gain+Loss17160897
    nsv469715CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for NOSIP:    
    About MalaCards
    alcoholic hepatitis    endotheliitis    hypertension    neuronitis
    malaria    hepatitis


    NOSIP for disorders           About GeneDecksing


    Export disorders for NOSIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOSIP gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NOSIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. (PubMed id 11149895)1, 2, 3 Dedio J....Mueller-Esterl W. (FASEB J. 2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. (PubMed id 16135813)1, 2, 9 Schleicher M.... Oess S. (Mol. Cell. Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. (PubMed id 15548660)1, 2 Dreyer J.... Kuner R. (J. Neurosci. 2004)
    6. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51070 HGNC: 17946 AceView: NOSIP Ensembl:ENSG00000142546 euGenes: HUgn51070
    ECgene: NOSIP H-InvDB: NOSIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOSIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NOSIP gene:
    Search GeneIP for patents involving NOSIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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