Aliases for NOS2 Gene
External Ids for NOS2 Gene
Previous Symbols for NOS2 Gene
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for NOS2 Gene
NOS2 (Nitric Oxide Synthase 2, Inducible) is a Protein Coding gene. Diseases associated with NOS2 include borderline leprosy and bladder carcinoma in situ. Among its related pathways are Disease and Pathways in cancer. GO annotations related to this gene include protein homodimerization activity and calmodulin binding. An important paralog of this gene is NOS1.
UniProtKB/Swiss-Prot for NOS2 Gene
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on Cys-247 implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.
Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active. Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required for catalytic activity. iNOS gene expression is regulated by various pathways including NF-kappaB, IFN-gamma (signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-beta and interleukins -4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS homodimerization by NAP110. iNOS has roles in the innate immune system and displays antibacterial, antiviral and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.