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NOS2 Gene

protein-coding GIFtS: 67
GCID: GC17M026083

Nitric Oxide Synthase 2, Inducible

(Previous names: nitric oxide synthase 2A (inducible, hepatocytes))
(Previous symbol: NOS2A)

See NOS2-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nitric Oxide Synthase 2, Inducible¹ ²		NOS Type II² ³
NOS2A¹ ² ³ ⁵		EC 1.14.13.39³ ⁸
Nitric Oxide Synthase 2A (Inducible, Hepatocytes)¹ ²		INOS²
Hepatocyte NOS² ³		NOS²
Inducible NO Synthase² ³		Nitric Oxide Synthase, Inducible²
Inducible NOS² ³		Nitric Oxide Synthase, Macrophage²
Peptidyl-Cysteine S-Nitrosylase NOS2² ³		NOS, Type II²
HEP-NOS² ³		iNOS³

External Ids:	HGNC: 7873¹	Entrez Gene: 4843²	Ensembl: ENSG00000007171⁷	OMIM: 163730⁵	UniProtKB: P35228³

Export aliases for NOS2 gene to outside databases

Previous GC identifers: GC17M023108 GC17M022290

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOS2 Gene:

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including

neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which

is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three

related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq,

Jul 2008)

GeneCards Summary for NOS2 Gene:

NOS2 (nitric oxide synthase 2, inducible) is a protein-coding gene. Diseases associated with NOS2 include virilizing ovarian tumor, and borderline leprosy. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is NOS3.

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In

macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates

cysteine S-nitrosylation of cytoplasmic target proteins such COX2

summary for NOS2 Gene:

Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial

nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and

molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active.

Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required

for catalytic activity. iNOS gene expression is regulated by various pathways including NF-kappaB, IFN-gamma

(signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-beta and interleukins

-4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS

homodimerization by NAP110. iNOS has roles in the innate immune system and displays antibacterial, antiviral

and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.

Gene Wiki entry for NOS2 (Nitric oxide synthase 2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Regulatory transcription factor binding sites in the NOS2 gene promoter:
p300 MyoD IRF-1 HNF-3beta HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOS2 promoter sequence

Search Chromatin IP Primers for NOS2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2-q12

NOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOS2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M026083: view genomic region (about GC identifiers)

Start:	26,083,792 bp from pter	End:	26,127,555 bp from pter
Size:	43,764 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228 (See protein sequence)

Recommended Name: Nitric oxide synthase, inducible

Size: 1153 amino acids; 131117 Da

Cofactor: Heme group (By similarity)

Cofactor: Binds 1 FAD (By similarity)

Cofactor: Binds 1 FMN (By similarity)

Cofactor: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity)

Subunit: Homodimer. Binds SLC9A3R1

Selected PDB 3D structures from and Proteopedia for NOS2 (see all 7):

1NSI (3D)

2LL6 (3D)

2NSI (3D)

3E7G (3D)

3EJ8 (3D)

3HR4 (3D)

Secondary accessions: A1L3U5 B7ZLY2 O60757 O94994 Q16263 Q16692 Q4TTS5 Q9UD42

Alternative splicing: 2 isoforms: P35228-1 P35228-2

Explore the universe of human proteins at neXtProt for NOS2: NX_P35228

Explore proteomics data for NOS2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for NOS2 (P35228) (see all 43)

VLEEFPS

GWYMGTE

LDITTPP

LQVFDAR

See NOS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000616.3

ENSEMBL proteins:

ENSP00000327251

Reactome Protein details: P35228

NOS2 Human Recombinant Protein Products:

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	Enzo Life Sciences proteins for NOS2
	OriGene Purified Protein for NOS2 OriGene Protein Over-expression Lysate for NOS2 OriGene MassSpec for NOS2 OriGene Custom Protein Services for NOS2
	GenScript Custom Purified and Recombinant Proteins Services for NOS2
	Novus Biologicals NOS2 Protein Novus Biologicals NOS2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for NOS2
	Search eBioscience for Proteins for NOS2
	Search GeneTex for Proteins for NOS2
	antibodies-online proteins for NOS2 (18 products)
	antibodies-online peptides for NOS2

NOS2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NOS2
	R&D Systems Antibodies for NOS2 (iNOS)
	OriGene Antibodies for NOS2 OriGene Custom Antibody Services for NOS2
	Novus Biologicals NOS2 Antibodies
	Abcam antibodies for NOS2 (P29475, P35228)
	Cloud-Clone Corp. Antibodies for NOS2
	ThermoFisher Antibody for NOS2
	antibodies-online antibodies for NOS2 (191 products)

NOS2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NOS2
	R&D Systems ELISAs for NOS2 (iNOS)
	GenScript Custom Assay Services for NOS2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NOS2 Cloud-Clone Corp. CLIAs for NOS2
	Search eBioscience for ELISAs for NOS2
	antibodies-online kits for NOS2 (51 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: Inducible NOS

Nitric oxide synthases

Selected InterPro protein domains (see all 10):

IPR017927 Fd_Rdtase_FAD-bd

IPR001094 Flavdoxin

IPR008254 Flavodoxin/NO_synth

IPR012144 NOS_euk

IPR004030 NO_synthase_oxygenase_dom

Graphical View of Domain Structure for InterPro Entry P35228

ProtoNet protein and cluster: P35228

Selected Blocks protein domains (see all 6):

IPB001094 Flavodoxin signature

IPB001433 Oxidoreductase FAD/NAD(P)-binding

IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature

IPB003097 FAD-binding

IPB004030 Nitric oxide synthase

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Similarity: Belongs to the NOS family

Similarity: Contains 1 FAD-binding FR-type domain

Similarity: Contains 1 flavodoxin-like domain

Find genes that share domains with NOS2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOS2_HUMAN, P35228

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In

macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates

cysteine S-nitrosylation of cytoplasmic target proteins such COX2

Catalytic activity: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O

Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and

effects may be exerted at the level of translational/post-translational modification and directly on the

catalytic activity (By similarity)

Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial

lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta

Enzyme Number (IUBMB): EC 1.14.13.39¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003958	NADPH-hemoprotein reductase activity	IBA	--
GO:0004517	nitric-oxide synthase activity	IDA	7504305
GO:0005102	receptor binding	IPI	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	12855682

Find genes that share ontologies with NOS2 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for NOS2:

Decreased viability after Chla

Increased gamma-H2AX phosphory

Selected MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nos2) (see all 23):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	endocrine/exocrine gland	growth/size/body	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

Find genes that share phenotypes with NOS2 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for NOS2: Nos2^tm1Mrl Nos2^tm1Lau Nos2^tm1Liew

genOway: Develop your customized and physiologically relevant rodent model for NOS2

miRNA Products:		miRTarBase miRNAs that target NOS2: hsa-mir-26a-5p (MIRT007347)

		Block miRNA regulation of human, mouse, rat NOS2 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate NOS2:
		hsa-miR-485-3p hsa-miR-323-5p
		SwitchGear 3'UTR luciferase reporter plasmid: NOS2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOS2
		Predesigned siRNA for gene silencing in human, mouse, rat NOS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NOS2

Clone Products:		OriGene clones in human, mouse for NOS2 (see all 6) OriGene ORF clones in mouse, rat for NOS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOS2
		Browse ESI BIO Cell Lines and PureStem Progenitors for NOS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-11043) for NOS2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
peroxisome	5
cytosol	3
nucleus	3
cytoskeleton	2
extracellular	2
mitochondrion	2
plasma membrane	2
endoplasmic reticulum	1
lysosome	1
vacuole	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	7544003
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	12085352
GO:0005777	peroxisome	IDA	12085352
GO:0005829	cytosol	TAS	--

Find genes that share ontologies with NOS2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for NOS2 About (see all 38)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Arginine and proline metabolism

	superpathway of citrulline metabolism	0.00			Arginine and proline metabolism
	citrulline-nitric oxide cycle	0.00

IL12-mediated signaling events

Immune response IL-12-induced IFN-gamma production

0.31

IL12-mediated signaling events

0.31

Bacterial infections in CF airways

Immune response Bacterial infections in normal airways

0.78

Bacterial infections in CF airways

0.78

Leishmaniasis

Leishmaniasis

0.35

Toxoplasmosis

0.35

Immune response CCR3 signaling in eosinophils

Immune response CCR3 signaling in eosinophils

0.51

Find genes that share SuperPaths with NOS2 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOS2 (see all 10)

	MIF Regulation of Innate Immune Cells
	MSP-RON Signaling
	Sertoli-Sertoli Cell Junction Dynamics
	Endothelin-1 Signaling Pathway
	Relaxin Pathway

Selected GeneGo (Thomson Reuters) Pathways for NOS2 (see all 11)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Development VEGF signaling via VEGFR2 - generic cascades
	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Selected BioSystems Pathways for NOS2 (see all 12)

	Type II interferon signaling (IFNG)
	AGE/RAGE pathway
	Spinal Cord Injury
	Effects of nitric oxide
	citrulline-nitric oxide cycle

2 Reactome Pathways for NOS2

	Phagosomal maturation (early endosomal stage)
	Nitric oxide stimulates guanylate cyclase

2 PharmGKB Pathways for NOS2

	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics

Selected Kegg Pathways (Kegg details for NOS2) (see all 14):

	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	HIF-1 signaling pathway
	Peroxisome

Pathway & Disease-focused RT² Profiler PCR Arrays including NOS2 (see all 14):

Insulin Signaling Pathway in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Interactions:

GeneGlobe Interaction Network for NOS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NOS2 (P35228³ ENSP00000327251⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158³, ENSP00000272298⁴	I2D: score=1 STRING: ENSP00000272298
CALM1	P62158³, ENSP00000349467⁴	I2D: score=1 STRING: ENSP00000349467
CALM3	P62158³	I2D: score=1
ACTN4	O43707³, ENSP00000252699⁴	I2D: score=4 STRING: ENSP00000252699
RAC2	P15153³, ENSP00000249071⁴	I2D: score=4 STRING: ENSP00000249071

About this table

Gene Ontology (GO): Selected biological process terms (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	TAS	10450191
GO:0002227	innate immune response in mucosa	NAS	18390757
GO:0006527	arginine catabolic process	IDA	7504305
GO:0006801	superoxide metabolic process	ISS	--

Find genes that share ontologies with NOS2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for NOS2

Browse compounds at ApexBio

Compounds for NOS2 available from Tocris Bioscience About this table

Compound	Action	CAS #
BYK 191023 dihydrochloride	Potent and selective inhibitor of iNOS	[608880-48-4]
L-NIL hydrochloride	Selective iNOS inhibitor	[150403-89-7]
1400W dihydrochloride	Potent, highly selective iNOS inhibitor	[180001-34-7]
AMT hydrochloride	Potent, selective iNOS inhibitor	[21463-31-0]
(S)-Methylisothiourea sulfate	Highly selective iNOS inhibitor	[867-44-7]

10 HMDB Compounds for NOS2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Citrulline	(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)	372-75-8	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Flavin Mononucleotide	FMN (see all 19)	146-17-8	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
L-Arginine	(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)	74-79-3	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Nitric oxide	Mononitrogen monoxide (see all 9)	10102-43-9	--
Tetrahydrobiopterin	(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol (see all 11)	17528-72-2	--

Selected DrugBank Compounds for NOS2 (see all 40) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Arginine	(S)-2-Amino-5-guanidinovaleric acid (see all 4)	74-79-3	target	--	17513447 17340133 16778961 17362916 17363779
L-Citrulline	2-Amino-5-uredovaleric acid (see all 8)	372-75-8	target	--	12745988 10906994 11742852 10906995 10944418
Aminoguanidine	--	79-17-4	target	inhibitor	17139284 11752352 17016423 10592235
Dexamethasone	Desametasone (see all 9)	50-02-2	target	negative modulator	17494951 17503181 11752352 17379310
Miconazole	--	22916-47-8	target	inhibitor	7536941 7518297 7683652 9873034
Triflusal	--	--	target	agonist	9551715 19465361 16939630 10998082
3-Bromo-7-Nitroindazole	--	--	target	--	17139284 17016423 10592235
4r-Fluoro-N6-Ethanimidoyl-L-Lysine	--	--	target	--	17139284 17016423 10592235
5-Nitroindazole	--	--	target	--	17139284 17016423 10592235
6-Nitroindazole	--	--	target	--	17139284 17016423 10592235

5 IUPHAR Ligands for NOS2 (Inducible NOS) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
1400W	Inhibitor	Inhibition	8.2	9030556
2-amino-4-methylpyridine	Inhibitor	Inhibition	7.4	8937711
PIBTU	Inhibitor	Inhibition	7.3	7523409
NIL	Inhibitor	Inhibition	5.5	7525961
aminoguanidine	Inhibitor	Inhibition	5.5	1378415

Selected Novoseek inferred chemical compound relationships for NOS2 gene (see all 124) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide	97.5	18892	11680730 (10), 11342896 (8), 16957516 (8), 18554637 (8) (see all 99)
citrulline	87.5	279	20148434 (3), 20148433 (3), 8561501 (3), 7527657 (2) (see all 99)
l-nmma	87.3	488	9503327 (4), 12810424 (3), 17724209 (3), 18090547 (3) (see all 99)
arginine	86.4	1048	16245240 (5), 11275358 (5), 8639550 (5), 7664438 (4) (see all 99)
peroxynitrite	86.2	233	11788351 (4), 9180331 (3), 10383909 (3), 9122229 (3) (see all 99)
aminoguanidine	84.9	363	9538001 (5), 16553284 (4), 18790185 (4), 11062159 (3) (see all 99)
adma	83.5	234	8743168 (5), 15325021 (4), 19682580 (4), 10802528 (3) (see all 99)
tetrahydrobiopterin	79.4	94	15565652 (2), 14609340 (2), 16052472 (2), 16172396 (2) (see all 67)
cgmp	78.8	303	18606420 (5), 10802528 (4), 11181408 (4), 8633049 (4) (see all 99)
n(g)-nitro-l-arginine methyl ester	76.8	176	11891189 (2), 7684763 (1), 7673269 (1), 8991992 (1) (see all 99)

2 PharmGKB related drug/compound annotations for NOS2 gene About this table

Drug/compound	PharmGKB Annotation
isoniazid	CA
rifampin	CA

Find genes that share compounds with NOS2 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for NOS2 gene (2 alternative transcripts):

NM_000625.4 NM_153292.1

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000313735(uc002gzu.3 uc010wab.1 uc010crh.1)

miRNA Products:		Block miRNA regulation of human, mouse, rat NOS2 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate NOS2:
		hsa-miR-485-3p hsa-miR-323-5p
		SwitchGear 3'UTR luciferase reporter plasmid: NOS2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOS2
		Predesigned siRNA for gene silencing in human, mouse, rat NOS2

Clone Products:		OriGene clones in human, mouse for NOS2 (see all 6) OriGene ORF clones in mouse, rat for NOS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NOS2
		QuantiTect SYBR Green Assays in human, mouse, rat NOS2
		QuantiFast Probe-based Assays in human, mouse, rat NOS2

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-11043) for NOS2

Selected AceView cDNA sequences (see all 75):

NM_153292 AW445097 S75615 S76479 BM834810 AW297448 BE073577 NM_000625

X73029 BE073638 AI797675 AW449618 AI953734 AI738789 CD609259 AI991263

L24553 U31511 CD609257 BV207664 BV188741 AA877840 CD609248 H67843

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NOS2 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:							-
SP2:							-
SP3:													-

ExUns:	26	^	27	^	28
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for NOS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGCATTT

About this image

NOS2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Bone (Muscoskeletal System)
HyStem+BMP4-induced 4D20.8 cells

Neural Ectoderm (Nervous System)
Neural ectoderm cells

Cartilage (Muscoskeletal System)
HyStem+BMP4-induced 4D20.8 cells

Neural Tube (Nervous System)
Floor plate-like cells

Brain (Nervous System)
N2/LSB induced-cells

NOS2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NOS2 Protein Expression

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not

expressed in the platelets

Pathway & Disease-focused RT² Profiler PCR Arrays including NOS2 (see all 14):

Insulin Signaling Pathway in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NOS2
		QuantiTect SYBR Green Assays in human, mouse, rat NOS2
		QuantiFast Probe-based Assays in human, mouse, rat NOS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOS2 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nos2^{1 , 5}	nitric oxide synthase 2, inducible^{1, 5}	82.4(n)¹ 81.21(a)¹		11 (46.74 cM)⁵ 18126¹ NM_010927.3¹ NP_035057.1¹ 78920787⁵
chicken (Gallus gallus)	Aves	NOS2¹	nitric oxide synthase 2, inducible	68.43(n) 70.46(a)		395807 NM_204961.1 NP_990292.1
lizard (Anolis carolinensis)	Reptilia	NOS2⁶	nitric oxide synthase 2, inducible	56(a)	1 ↔ 1	GL343729.1(116369-178014)
tropical clawed frog (Xenopus tropicalis)	Amphibia	nos2¹	nitric oxide synthase 2, inducible	65.96(n) 65.96(a)		100494698 XM_002935296.2 XP_002935342.2
zebrafish (Danio rerio)	Actinopterygii	nos2b¹	nitric oxide synthase 2b, inducible	61.56(n) 60.63(a)		563654 NM_001113501.1 NP_001106973.1
fruit fly (Drosophila melanogaster)	Insecta	Nos⁶	Nitric oxide synthase	38(a)	1 → many	2L(10804269-10838448)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NCP1⁶	NADP-cytochrome P450 reductase; involved in ergost...	24(a)	1 → many	VIII(190543-192618) YHR042W

ENSEMBL Gene Tree for NOS2 (if available)
TreeFam Gene Tree for NOS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for NOS2 gene

NOS3² POR² MTRR² NOS1²

2 SIMAP similar genes for NOS2 using alignment to 1 protein entry: NOS2_HUMAN:

NOS1 NOS3

Find genes that share paralogs with NOS2 About GenesLikeMe

Selected Pseudogenes.org Pseudogenes for NOS2 (see all 15)
PGOHUM00000247699 PGOHUM00000248028 PGOHUM00000250807 PGOHUM00000237000 PGOHUM00000237005

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Polymorphic Variants from UniProtKB/Swiss-Prot

NOS2_HUMAN, P35228: Note=Genetic variations in NOS2 are involved in resistance to malaria [MIM:611162]

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036302⁴		A breast cancer sample⁴	--	see VAR_036302	2	A S	mis⁴		0	--	--	--	--
rs59685746^1,2	C	--	26088338(+)	`CACGG-/CCCTCC`	1	--	int¹		3		NA CSA	8
rs5819821^1,2	C,F	--	26106756(+)	`CAGAAA/-GCTGG`	1	--	int¹		7		NS NA CSA	178
rs112336932^1,2	C	--	26115222(+)	`GCGTGCACA/- CACAC`	1	--	int¹		1		CSA	2
rs59431357^1,2	C,F	--	26115249(+)	`CACAC-/AC/ACAC/ACACAC ACAC/ACACACACACACGAATG`	2	--	int¹ cds¹		2		NA	4
rs34992777^1,2	C	--	26119841(+)	`CTACAA/-AAAAA`	1	--	int¹		1		NA	2
rs28998799^1,2	C,F	--	26126131(-)	`GGGGGG/-TTCAT`	1	--	int¹		6		NS NA	184
rs35834812^1,2	C	--	26126817(+)	`AAAAA-/AGAAAG`	1	--	int¹		1		NA	2
rs146226023^1,2		--	26143243(+)	`TCCTTA/GGCCTG`	1	--	ds500¹		0	--	--	--	--
rs115428634^1,2	F	--	26143250(+)	`CCTGCT/ACCAAA`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for NOS2 (26083792 - 26127555 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for NOS2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2715781	CNV	Deletion	23290073
nsv9533	CNV	Gain	18304495
esv28579	CNV	Gain	19812545
dgv943e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): NOS2
Locus Specific Mutation Databases (LSDB): NOS2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NOS2

DNA2.0 Custom Variant and Variant Library Synthesis for NOS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 163730
OMIM disorders: 145500  611162
Selected diseases for NOS2 (see all 34):
About MalaCards

virilizing ovarian tumor borderline leprosy warthin tumor pityriasis lichenoides

bladder carcinoma in situ malaria hypertension collagenous colitis

colitis peyronie's disease lip cancer hemorrhoid

internal hemorrhoid crohn's colitis colonic disease myocarditis

idiopathic achalasia sleeping sickness periapical granuloma retinal vasculitis

3 inferred disease relationships from the University of Copenhagen DISEASES database for NOS2:

Vascular disease Gastrointestinal system disease Arthritis

Find genes that share disorders with NOS2 About GenesLikeMe

96 Novoseek inferred disease relationships for NOS2 gene (see top 10) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	76.7	531	14657339 (3), 17449036 (3), 16537027 (3), 12613978 (3) (see all 99)
necrosis	75.9	590	16827641 (4), 17452936 (3), 9856818 (3), 10713108 (3) (see all 99)
tumors	64.1	1265	11156233 (6), 17980097 (6), 16557582 (5), 20338478 (5) (see all 99)
shock septic	63.8	96	7536056 (4), 12594864 (3), 14654318 (3), 10791377 (3) (see all 58)
sepsis	54.4	152	12016107 (5), 17997414 (4), 12594864 (3), 10669117 (3) (see all 72)
atherosclerosis	51.8	77	8683942 (3), 10073969 (3), 10334927 (2), 11139364 (2) (see all 47)
neurodegenerative diseases	50.5	18	16144552 (1), 7523410 (1), 11246231 (1), 16807879 (1) (see all 11)
inflammatory bowel diseases	46.6	44	17955236 (2), 12792224 (2), 10102942 (1), 10630438 (1) (see all 28)
cell damage	46.4	28	11218753 (2), 9377819 (1), 11139364 (1), 11488434 (1) (see all 22)
ischemia	46.1	102	15327760 (4), 16154689 (4), 11708836 (3), 8787213 (3) (see all 61)
colitis	45.7	61	19238344 (4), 16165717 (4), 19285099 (4), 11282554 (3) (see all 28)
shock endotoxic	43.6	9	7536934 (1), 9628258 (1), 11292370 (1), 9556848 (1) (see all 6)
shock	43.6	93	16937286 (3), 14654318 (2), 8751576 (2), 10385249 (2) (see all 66)
vascular diseases	43.5	24	12504936 (2), 10779466 (1), 15051034 (1), 15542378 (1) (see all 13)
lymphoma t-cell peripheral	43	12	16124164 (1), 12166895 (1), 19031731 (1), 17582237 (1) (see all 12)
peyronie disease	42.6	13	12454685 (2), 12446175 (1), 12009846 (1), 14996430 (1) (see all 7)
neurodegeneration	42.1	24	16165295 (2), 11240010 (2), 11324986 (1), 11689164 (1) (see all 15)
osteoarthritis	41	27	12856254 (2), 9236674 (2), 9870873 (2), 10419769 (1) (see all 17)
invasive ductal breast carcinoma	39.7	5	9012463 (1), 15883814 (1), 11592099 (1), 9651946 (1) (see all 5)
hypertension pulmonary	39.5	30	11371423 (3), 12904860 (2), 16169754 (2), 9486205 (1) (see all 19)
cardiovascular diseases	39.2	34	19463074 (3), 9703761 (2), 12233810 (2), 7546624 (1) (see all 21)
erectile dysfunction	38.5	12	9096878 (4), 11781741 (1), 16507050 (1), 9631946 (1) (see all 9)
malaria cerebral	38.5	16	10971704 (3), 12552317 (3), 15960706 (2), 19153766 (1) (see all 8)
gastritis	37.3	51	10348815 (5), 11267845 (5), 14760971 (4), 9926291 (3) (see all 21)
pathological processes	36.6	18	14599552 (1), 16540395 (1), 11553314 (1), 18287515 (1) (see all 11)
hypotension	36.2	37	9628258 (2), 7536934 (1), 9118670 (1), 9892267 (1) (see all 28)
colitis ulcerative	34.5	57	10901620 (6), 9771406 (4), 8831582 (3), 15753535 (3) (see all 31)
multiple sclerosis	32.2	36	15145615 (3), 9506556 (2), 9665945 (2), 11395383 (2) (see all 19)
rheumatoid arthritis	31.7	47	12826065 (3), 12621554 (2), 12140750 (2), 10614169 (2) (see all 27)
alzheimers disease	31.7	41	12384247 (3), 10789135 (2), 11556547 (2), 8879214 (2) (see all 23)
carcinoma ductal	30.5	43	8861838 (3), 8958553 (2), 7909010 (2), 20174726 (2) (see all 28)
cerebral vasospasm	29.9	6	17977265 (2), 18590437 (1), 12233810 (1), 18807216 (1)
adenocarcinoma	29.9	110	10970689 (4), 9679948 (3), 11373104 (3), 9921950 (2) (see all 69)
collagenous colitis	29.9	7	16957516 (2), 11511561 (2), 12229970 (1), 15641395 (1)
periapical granuloma	29.8	7	16507070 (2), 17258631 (2), 19037921 (1)
chromosome 8 trisomy	29.7	1	9283590 (1)
vasospasm	29.6	12	17369785 (2), 17053178 (2), 8875487 (1), 12800488 (1) (see all 9)
aids dementia complex	28.4	3	10199221 (1)
heart failure	28.3	111	16803456 (6), 15366433 (5), 8653828 (4), 9851365 (3) (see all 44)
astrocytoma	27.8	46	11866952 (4), 15088099 (4), 16724682 (4), 9223073 (2) (see all 21)
cancer	27.3	220	19875457 (5), 10331487 (4), 12374680 (3), 19164562 (3) (see all 99)
nasal polyps	27	56	15362679 (5), 9515595 (4), 8777951 (3), 15490564 (3) (see all 16)
breast carcinoma	26.9	38	10873093 (4), 1332483 (3), 1701960 (3), 9012463 (2) (see all 22)
diabetes autoimmune	26.6	2	8594615 (1), 9375806 (1)
cerebral ischemia	25.7	36	10079976 (2), 15228594 (2), 16395420 (2), 8875487 (1) (see all 17)
colon cancer	25.7	32	19925669 (4), 16216410 (2), 9443414 (2), 15476855 (2) (see all 20)
hyperplasia	25.7	58	16552960 (4), 9740187 (3), 15694929 (3), 11819093 (2) (see all 26)
encephalomyelitis	25.4	14	9510198 (2), 9762676 (1), 15856071 (1), 12203391 (1) (see all 10)
acute respiratory distress	25.2	4	11179131 (1), 20477340 (1), 20388761 (1)
airways disease	24.9	4	17979023 (1), 7546629 (1), 10767722 (1)
glomerulosclerosis, focal segmental	24.7	2	10198566 (1), 17021605 (1)
carcinoma	24.6	173	19701111 (7), 11930727 (4), 11956620 (4), 17663360 (3) (see all 81)
arthritis	24.5	48	14719189 (3), 12826065 (3), 12672181 (3), 8991992 (2) (see all 25)
adenoma basal cell	24.4	2	9684573 (1), 8986967 (1)
liposarcoma pleomorphic	24.3	1	20305534 (1)
adenoma pleomorphic	23.6	16	10890559 (6), 19799816 (2), 9684573 (1), 15880136 (1) (see all 10)
asthma	23.4	117	8680689 (4), 18341205 (4), 17189532 (4), 12974195 (3) (see all 57)
multiple organ failure	23	2	14556720 (1), 9444610 (1)
encephalitis	23	11	11282169 (2), 9951625 (1), 7491773 (1), 10320031 (1) (see all 6)
shock hemorrhagic	21.8	22	10353536 (5), 7537167 (2), 12578118 (2), 7678341 (1) (see all 9)
brain diseases	21.8	5	10395902 (1), 7530762 (1), 19519641 (1)
associated conditions	21.5	7	11532247 (1), 8842429 (1), 11282169 (1), 8779963 (1) (see all 5)
glioma	21.3	75	12617238 (4), 15683746 (4), 11693258 (4), 19629394 (3) (see all 34)
glomerulonephritis	21.1	30	12454221 (5), 10589693 (3), 1280702 (2), 7573358 (2) (see all 14)
preeclampsia	21	57	8743168 (5), 11327094 (4), 11166745 (4), 19776611 (4) (see all 21)
immunopathology	19.6	1	11748285 (1)
carcinoma adenoid cystic	19.3	12	16243805 (2), 15584054 (1), 19574086 (1), 8986967 (1) (see all 10)
salivary gland adenocarcinoma	19.3	1	7684204 (1)
carcinoma mucoepidermoid	19.3	8	9684573 (1), 15880136 (1), 16996786 (1), 7684204 (1) (see all 7)
respiratory distress syndrome	18.4	4	11179131 (1), 20477340 (1), 20388761 (1)
senile plaques	18.1	6	10560659 (2), 11716809 (1), 19660523 (1), 15571982 (1) (see all 5)
uremia	17.8	4	8734457 (2), 9029246 (1)
supraglottic squamous cell carcinoma	17.7	4	12508542 (2), 12969533 (1)
renal disease	17.2	26	17070441 (2), 7546625 (2), 9607210 (1), 11267247 (1) (see all 19)
metastasis	17.1	116	10188914 (4), 11400148 (3), 9237172 (3), 12943630 (3) (see all 63)
carcinoma squamous cell	16.8	87	16552960 (4), 12369071 (4), 12452003 (4), 10339659 (4) (see all 43)
myoepithelioma	16.7	2	8986967 (1), 9471611 (1)
occlusion middle cerebral artery	16.1	4	15228594 (2)
malignant fibrous histiocytoma	16	6	15702318 (2), 20368975 (1), 20464676 (1), 1309926 (1) (see all 5)
lymphocytic leukemia chronic b-cell	15.7	4	14574328 (1), 17642141 (1), 18474259 (1), 9680373 (1)
diabetic retinopathy	15.4	10	10506586 (2), 9292247 (1), 17337232 (1), 18065828 (1) (see all 7)
neovascularization	14.6	2	9921950 (1), 9846573 (1)
hypercholesterolemia	14.5	8	19505368 (2), 10377069 (1), 15524164 (1), 16228201 (1) (see all 7)
mpnst	13.9	1	11554386 (1)
demyelination	13.9	10	15145615 (1), 10190690 (1), 10494107 (1), 9058833 (1) (see all 7)
renal ischemia	13.9	4	16540395 (2), 11849438 (1), 16495814 (1)
glomerulosclerosis	13.8	4	10198566 (1), 8743536 (1), 15855741 (1)
hyperglycemia	13.7	22	15855318 (4), 17804300 (3), 19539448 (2), 15479219 (2) (see all 11)
edema	13.7	34	11245273 (2), 8799551 (2), 18854985 (2), 15015560 (1) (see all 17)
myocardial ischemia	13.6	30	9545547 (1), 9689595 (1), 11708836 (1), 12702642 (1) (see all 16)
gastritis chronic	13	4	9802453 (2), 15191513 (1), 19077474 (1)
malaria falciparum	12.9	9	12888113 (1), 12716455 (1), 17543124 (1), 9764323 (1) (see all 7)
carcinoma lobular	12.9	10	15365566 (1), 2173410 (1), 8861838 (1), 1346789 (1) (see all 7)
glioblastoma	12.8	20	8742473 (2), 10769671 (2), 10369188 (1), 14676405 (1) (see all 12)
myocarditis	12.8	12	8978317 (4), 9244230 (4), 11901182 (1), 7568904 (1)
asthma allergic	12.7	5	8590967 (1), 10556950 (1), 9655713 (1), 10330441 (1) (see all 5)

Genetic Association Database (GAD): NOS2
Human Genome Epidemiology (HuGE) Navigator: NOS2 (192 documents)

Export disorders for NOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NOS2 gene, integrated from 10 sources (see all 4100):
(articles sorted by number of sources associating them with NOS2)

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. (PubMed id 7682706)^{1, 2, 3, 9} Geller D.A....Billiar T.R. (Proc. Natl. Acad. Sci. U.S.A. 1993)
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (PubMed id 12433515)^{1, 2, 4, 9} Hobbs M.R.... Weinberg J.B. (Lancet 2002)
Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. (PubMed id 9160867)^{1, 2, 9} Luss H.... Billiar T.R. (J. Mol. Cell. Cardiol. 1997)
Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis. (PubMed id 19327239)^{1, 4, 9} Gonzalez-Gay M.A....Martin J. (Clin. Exp. Rheumatol. 2009)
Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. (PubMed id 19996333)^{1, 4, 9} Islam T....Gilliland F.D. (Thorax 2010)
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. (PubMed id 19859740)^{1, 4, 9} Levesque M.C....Weinberg J.B. (Hum. Genet. 2010)
The CCTTT pentanucleotide microsatellite in iNOS promoter influences the clinical outcome in P. falciparum infection. (PubMed id 19153766)^{1, 4, 9} Dhangadamajhi G....Ranjit M.R. (Parasitol. Res. 2009)
Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. (PubMed id 19242068)^{1, 4, 9} Bohanec Grabar P....Dolzan V. (Dis. Markers 2009)
NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis. (PubMed id 19635578)^{1, 4, 9} VaradAc J....Urcelay E. (Nitric Oxide 2009)
Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. (PubMed id 10409685)^{1, 2, 9} Li H.... Poulos T.L. (J. Biol. Chem. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4843	HGNC: 7873	AceView: NOS2A	Ensembl:ENSG00000007171	euGenes: HUgn4843
ECgene: NOS2	Kegg: 4843	H-InvDB: NOS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NOS2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/nos2a/
Wikipedia	http://en.wikipedia.org/wiki/Nitric_oxide_synthase

Intellectual Property for NOS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NOS2 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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Nitric Oxide Synthase 2, Inducible

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NOS2 Gene

Nitric Oxide Synthase 2, Inducible

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