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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NOS2 Gene

protein-coding GIFtS: 70
GCID: GC17M026083

Nitric Oxide Synthase 2, Inducible

(Previous names: nitric oxide synthase 2A (inducible, hepatocytes))
(Previous symbol: NOS2A)

Microbiology & Infectious Diseases Congress

358 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nitric Oxide Synthase 2, Inducible¹ ²		NOS Type II² ³
NOS2A¹ ² ³ ⁵		EC 1.14.13.39³ ⁸
Nitric Oxide Synthase 2A (Inducible, Hepatocytes)¹ ²		INOS²
Hepatocyte NOS² ³		NOS²
Inducible NO Synthase² ³		Nitric Oxide Synthase, Inducible²
Inducible NOS² ³		Nitric Oxide Synthase, Macrophage²
Peptidyl-Cysteine S-Nitrosylase NOS2² ³		NOS, Type II²
HEP-NOS² ³		iNOS³

External Ids:	HGNC: 7873¹	Entrez Gene: 4843²	Ensembl: ENSG00000007171⁷	OMIM: 163730⁵	UniProtKB: P35228³

Export aliases for NOS2 gene to outside databases

Previous GC identifers: GC17M023108 GC17M022290

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOS2 Gene:

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including

neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which

is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three

related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq,

Jul 2008)

GeneCards Summary for NOS2 Gene:

NOS2 (nitric oxide synthase 2, inducible) is a protein-coding gene. Diseases associated with NOS2 include virilizing ovarian tumor, and pityriasis lichenoides, and among its related super-pathways are Immune response IL-12-induced IFN-gamma production and Bacterial infections in CF airways. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is NOS3.

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In

macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates

cysteine S-nitrosylation of cytoplasmic target proteins such COX2

summary for NOS2 Gene:

Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial

nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and

molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active.

Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required

for catalytic activity. iNOS gene expression is regulated by various pathways including NF-kappaB, IFN-gamma

(signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-beta and interleukins

-4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS

homodimerization by NAP110. iNOS has roles in the innate immune system and displays antibacterial, antiviral

and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.

Gene Wiki entry for NOS2 (Nitric oxide synthase 2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.2 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NOS2 gene promoter:
p300 MyoD IRF-1 HNF-3beta HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOS2 promoter sequence

Search SABiosciences Chromatin IP Primers for NOS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2-q12

NOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOS2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M026083: view genomic region (about GC identifiers)

Start:	26,083,792 bp from pter	End:	26,127,555 bp from pter
Size:	43,764 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228 (See protein sequence)

Recommended Name: Nitric oxide synthase, inducible

Size: 1153 amino acids; 131117 Da

Cofactor: Heme group (By similarity)

Cofactor: Binds 1 FAD (By similarity)

Cofactor: Binds 1 FMN (By similarity)

Cofactor: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity)

Subunit: Homodimer. Binds SLC9A3R1

6/7 PDB 3D structures from and Proteopedia for NOS2 (see all 7):

1NSI (3D)

2LL6 (3D)

2NSI (3D)

3E7G (3D)

3EJ8 (3D)

3HR4 (3D)

Secondary accessions: A1L3U5 B7ZLY2 O60757 O94994 Q16263 Q16692 Q4TTS5 Q9UD42

Alternative splicing: 2 isoforms: P35228-1 P35228-2

Explore the universe of human proteins at neXtProt for NOS2: NX_P35228

Explore proteomics data for NOS2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P35228

4/43 DME Specific Peptides for NOS2 (P35228) (see all 43)

VLEEFPS

GWYMGTE

LDITTPP

LQVFDAR

NOS2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_000616.3

ENSEMBL proteins:

ENSP00000327251

Reactome Protein details: P35228
Human Recombinant Protein Products for NOS2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for NOS2
	OriGene Purified Protein for NOS2 OriGene Protein Over-expression Lysate for NOS2 OriGene MassSpec for NOS2 OriGene Custom Protein Services for NOS2
	GenScript Custom Purified and Recombinant Proteins Services for NOS2
	Novus Biologicals NOS2 Protein Novus Biologicals NOS2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for NOS2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	7544003
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	12085352
GO:0005777	peroxisome	IDA	12085352
GO:0005829	cytosol	TAS	--

NOS2 for ontologies About GeneDecksing

NOS2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NOS2
	R&D Systems Antibodies for NOS2 (iNOS)
	Browse OriGene Antibodies OriGene Custom Antibody Services for NOS2
	GenScript Custom Superior Antibodies Services for NOS2
	Novus Biologicals NOS2 Antibodies
	Abcam antibodies for NOS2
	Cloud-Clone Corp. Antibodies for NOS2
	ThermoFisher Antibody for NOS2
	LSBio Antibodies in human, mouse, rat for NOS2

Assay Products for NOS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NOS2
	R&D Systems ELISAs for NOS2 (iNOS)
	GenScript Custom Assay Services for NOS2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NOS2 Cloud-Clone Corp. CLIAs for NOS2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IUPHAR Guide to PHARMACOLOGY protein family classification: Inducible NOS

Nitric oxide synthases

5/11 InterPro protein domains (see all 11):

IPR026009 NOS

IPR017927 Fd_Rdtase_FAD-bd

IPR001094 Flavdoxin

IPR008254 Flavodoxin/NO_synth

IPR001433 OxRdtase_FAD/NAD-bd

Graphical View of Domain Structure for InterPro Entry P35228

ProtoNet protein and cluster: P35228

5/6 Blocks protein domains (see all 6):

IPB001094 Flavodoxin signature

IPB001433 Oxidoreductase FAD/NAD(P)-binding

IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature

IPB003097 FAD-binding

IPB004030 Nitric oxide synthase

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Similarity: Belongs to the NOS family

Similarity: Contains 1 FAD-binding FR-type domain

Similarity: Contains 1 flavodoxin-like domain

NOS2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOS2_HUMAN, P35228

Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In

macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates

cysteine S-nitrosylation of cytoplasmic target proteins such COX2

Catalytic activity: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O

Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and

effects may be exerted at the level of translational/post-translational modification and directly on the

catalytic activity (By similarity)

Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial

lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta

Enzyme Number (IUBMB): EC 1.14.13.39¹ ²

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003958	NADPH-hemoprotein reductase activity	IBA	--
GO:0004517	nitric-oxide synthase activity	IDA	7504305
GO:0005102	receptor binding	IPI	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	12855682

NOS2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for NOS2:

Decreased viability after Chla

Increased gamma-H2AX phosphory

15/23 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nos2) (see all 23):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

NOS2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for NOS2: Nos2^tm1Mrl Nos2^tm1Lau Nos2^tm1Liew

inGenious Targeting Laboratory - Custom generated mouse model solutions for NOS2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOS2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOS2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOS2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOS2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NOS2:
		hsa-miR-485-3p hsa-miR-323-5p
		SwitchGear 3'UTR luciferase reporter plasmid: NOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NOS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOS2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NOS2
			Sirion Biotech Customized adenovirus for overexpression of NOS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for NOS2 (see all 7) OriGene ORF clones in mouse, rat for NOS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2
		Sirion Biotech Customized lentivirus for stable overexpression of NOS2 Customized lentivirus expression plasmids for stable overexpression of NOS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOS2
		Search LifeMap BioReagents cell lines for NOS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for NOS2 About (see all 37)

See pathways by source

SuperPath

Contained pathways About

Immune response IL-12-induced IFN-gamma production

Immune response IL-12-induced IFN-gamma production

0.88

IL12-mediated signaling events

0.33

Immune response Bacterial infections in normal airways

Immune response Bacterial infections in normal airways

0.78

Bacterial infections in CF airways

0.78

Nitric oxide stimulates guanylate cyclase

Nitric oxide stimulates guanylate cyclase

0.75

Platelet homeostasis

0.34

Insulin receptor recycling

Latent infection of Homo sapiens with Mycobacterium tuberculosis

0.64

Phagosomal maturation (early endosomal stage)

0.64

Toll Comparative Pathway

Immune response MIF in innate immunity response

0.46

Immune response IL-1 signaling pathway

0.41

Pathways by source See SuperPaths
Show all pathways

5/6 EMD Millipore Pathways for NOS2 (see all 6)

	Immune response IL-12-induced IFN-gamma production
	G-protein signaling Rac2 regulation pathway
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Immune response CCR3 signaling in eosinophils

5/11 GeneGo (Thomson Reuters) Pathways for NOS2 (see all 11)

	Immune response MIF-mediated glucocorticoid regulation
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Development VEGF signaling via VEGFR2 - generic cascades
	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

5/11 BioSystems Pathways for NOS2 (see all 11)

	Type II interferon signaling (IFNG)
	Spinal Cord Injury
	AGE/RAGE pathway
	Prolactin Signaling Pathway
	citrulline-nitric oxide cycle

5/6 Reactome Pathways for NOS2 (see all 6)

	Hemostasis
	Phagosomal maturation (early endosomal stage)
	Latent infection of Homo sapiens with Mycobacterium tuberculosis
	Platelet homeostasis
	Nitric oxide stimulates guanylate cyclase

2 PharmGKB Pathways for NOS2

	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics

5/14 Kegg Pathways (Kegg details for NOS2) (see all 14):

	Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	HIF-1 signaling pathway
	Peroxisome

NOS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NOS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/60 Interacting proteins for NOS2 (P35228³ ENSP00000327251⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158³, ENSP00000272298⁴	I2D: score=1 STRING: ENSP00000272298
CALM1	P62158³, ENSP00000349467⁴	I2D: score=1 STRING: ENSP00000349467
CALM3	P62158³	I2D: score=1
ACTN4	O43707³, ENSP00000252699⁴	I2D: score=4 STRING: ENSP00000252699
RAC2	P15153³, ENSP00000249071⁴	I2D: score=4 STRING: ENSP00000249071

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001912	positive regulation of leukocyte mediated cytotoxicity	TAS	10450191
GO:0002227	innate immune response in mucosa	NAS	18390757
GO:0006527	arginine catabolic process	IDA	7504305
GO:0006801	superoxide metabolic process	ISS	--

NOS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NOS2 for compounds About GeneDecksing

EMD Millipore small molecules for NOS2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for NOS2

Compounds for NOS2 available from Tocris Bioscience About this table

Compound	Action	CAS #
BYK 191023 dihydrochloride	Potent and selective inhibitor of iNOS	[608880-48-4]
L-NIL hydrochloride	Selective iNOS inhibitor	[150403-89-7]
1400W dihydrochloride	Potent, highly selective iNOS inhibitor	[180001-34-7]
AMT hydrochloride	Potent, selective iNOS inhibitor	[21463-31-0]
(S)-Methylisothiourea sulfate	Highly selective iNOS inhibitor	[867-44-7]

10 HMDB Compounds for NOS2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Citrulline	(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)	372-75-8	--
FAD	1H-Purin-6-amine flavin dinucleotide (see all 21)	146-14-5	--
Flavin Mononucleotide	FMN (see all 19)	146-17-8	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
L-Arginine	(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)	74-79-3	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Nitric oxide	Mononitrogen monoxide (see all 9)	10102-43-9	--
Tetrahydrobiopterin	(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol (see all 11)	17528-72-2	--

10/40 DrugBank Compounds for NOS2 (see all 40) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Arginine	(S)-2-Amino-5-guanidinovaleric acid (see all 4)	74-79-3	target	--	17513447 17340133 16778961 17362916 17363779
L-Citrulline	2-Amino-5-uredovaleric acid (see all 8)	372-75-8	target	--	12745988 10906994 11742852 10906995 10944418
Aminoguanidine	--	79-17-4	target	inhibitor	17139284 11752352 17016423 10592235
Dexamethasone	Desametasone (see all 9)	50-02-2	target	negative modulator	17494951 17503181 11752352 17379310
Miconazole	--	22916-47-8	target	inhibitor	7536941 7518297 7683652 9873034
Triflusal	--	--	target	agonist	9551715 19465361 16939630 10998082
3-Bromo-7-Nitroindazole	--	--	target	--	17139284 17016423 10592235
4r-Fluoro-N6-Ethanimidoyl-L-Lysine	--	--	target	--	17139284 17016423 10592235
5-Nitroindazole	--	--	target	--	17139284 17016423 10592235
6-Nitroindazole	--	--	target	--	17139284 17016423 10592235

5 IUPHAR Ligands for NOS2 (Inducible NOS) About this table

Ligand	Type	Action	Affinity	Pubmed IDs
1400W	Inhibitor	Inhibition	8.2	9030556
2-amino-4-methylpyridine	Inhibitor	Inhibition	7.4	8937711
PIBTU	Inhibitor	Inhibition	7.3	7523409
NIL	Inhibitor	Inhibition	5.5	7525961
aminoguanidine	Inhibitor	Inhibition	5.5	1378415

10/124 Novoseek inferred chemical compound relationships for NOS2 gene (see all 124) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nitric oxide	97.5	18892	11680730 (10), 11342896 (8), 16957516 (8), 18554637 (8) (see all 99)
citrulline	87.5	279	20148434 (3), 20148433 (3), 8561501 (3), 7527657 (2) (see all 99)
l-nmma	87.3	488	9503327 (4), 12810424 (3), 17724209 (3), 18090547 (3) (see all 99)
arginine	86.4	1048	16245240 (5), 11275358 (5), 8639550 (5), 7664438 (4) (see all 99)
peroxynitrite	86.2	233	11788351 (4), 9180331 (3), 10383909 (3), 9122229 (3) (see all 99)
aminoguanidine	84.9	363	9538001 (5), 16553284 (4), 18790185 (4), 11062159 (3) (see all 99)
adma	83.5	234	8743168 (5), 15325021 (4), 19682580 (4), 10802528 (3) (see all 99)
tetrahydrobiopterin	79.4	94	15565652 (2), 14609340 (2), 16052472 (2), 16172396 (2) (see all 67)
cgmp	78.8	303	18606420 (5), 10802528 (4), 11181408 (4), 8633049 (4) (see all 99)
n(g)-nitro-l-arginine methyl ester	76.8	176	11891189 (2), 7684763 (1), 7673269 (1), 8991992 (1) (see all 99)

Search CenterWatch for drugs/clinical trials and news about NOS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NOS2 gene (2 alternative transcripts):

NM_000625.4 NM_153292.1

Unigene Cluster for NOS2:

Nitric oxide synthase 2, inducible

Hs.709191 [show with all ESTs]

Unigene Representative Sequence: NM_000625

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000313735(uc002gzu.3 uc010wab.1 uc010crh.1)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOS2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NOS2:
		hsa-miR-485-3p hsa-miR-323-5p
		SwitchGear 3'UTR luciferase reporter plasmid: NOS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NOS2
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		GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2
		Sirion Biotech Customized lentivirus for stable overexpression of NOS2 Customized lentivirus expression plasmids for stable overexpression of NOS2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOS2

Additional mRNA sequence:

AB022318.1 AF068236.1 AK304252.1 BC130283.1 BC144126.1 D26525.1 L09210.1 L24553.1

S75615.1 S76479.1 U05810.1 U20141.1 U31511.1 X73029.1

2 DOTS entries:

DT.412801 DT.95333286

24/75 AceView cDNA sequences (see all 75):

NM_000625 L24553 AI991263 X73029 AI738789 CD609259 BE073577 S76479

BE073638 AI797675 S75615 BM834810 AW297448 U31511 AW449618 AI953734

AW445097 NM_153292 U20141 U05810 CD609228 BG099280 CD609248 AA877840

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NOS2 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:							-
SP2:							-
SP3:													-

ExUns:	26	^	27	^	28
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for NOS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOS2 expression in normal human tissues (normalized intensities) NOS2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AATTGCATTT

About this image

NOS2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/4 selected tissues (see all 4) fully expand


Cartilage (Muscoskeletal System) fully expand to see all 2 entries
HyStem+BMP4-induced 4D20.8 cells
fetal cartilage

Bone (Muscoskeletal System)
HyStem+BMP4-induced 4D20.8 cells

Brain (Nervous System)
N2/LSB induced-cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...

Colon (Gastrointestinal Tract)

See NOS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOS2

SOURCE GeneReport for Unigene cluster: Hs.709191

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not

expressed in the platelets

SABiosciences Expression via Pathway-Focused PCR Arrays including NOS2 (see all 14):

Insulin Signaling Pathway in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NOS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOS2 gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nos2^{1 , 5}	nitric oxide synthase 2, inducible^{1, 5}	82.4(n)¹ 81.21(a)¹		11 (46.74 cM)⁵ 18126¹ NM_010927.3¹ NP_035057.1¹ 78920787⁵
chicken (Gallus gallus)	Aves	NOS2¹	nitric oxide synthase 2, inducible	68.43(n) 70.46(a)		395807 NM_204961.1 NP_990292.1
lizard (Anolis carolinensis)	Reptilia	NOS2⁶	nitric oxide synthase 2, inducible	56(a)	1 ↔ 1	GL343729.1(116369-178014)
zebrafish (Danio rerio)	Actinopterygii	nos2b¹	nitric oxide synthase 2b, inducible	61.56(n) 60.63(a)		563654 NM_001113501.1 NP_001106973.1
fruit fly (Drosophila melanogaster)	Insecta	Nos⁶ CG14882⁶	--	38(a) 24(a)	1 ↔ many possible ortholog	2L(10804269-10838448) 3R(12268966-12270526)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NCP1⁶	NADP-cytochrome P450 reductase; involved in ergost...	23(a)	1 → many	VIII(190543-192618)

ENSEMBL Gene Tree for NOS2 (if available)
TreeFam Gene Tree for NOS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NOS2 gene

NOS3² POR² MTRR² NOS1²

2 SIMAP similar genes for NOS2 using alignment to 1 protein entry: NOS2_HUMAN:

NOS1 NOS3

NOS2 for paralogs About GeneDecksing

5/15 Pseudogenes.org Pseudogenes for NOS2 (see all 15)
PGOHUM00000247699 PGOHUM00000248028 PGOHUM00000250807 PGOHUM00000237000 PGOHUM00000237005

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228

Polymorphism: Note=Genetic variations in NOS2 are involved in resistance to malaria [MIM:611162]

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_036302⁴		A breast cancer sample⁴	--	see VAR_036302	2	A S	mis⁴		0	--	--	--	--
rs59685746^1,2	C	--	26088338(+)	`CACGG-/CCCTCC`	1	--	int¹		3		NA CSA	8
rs5819821^1,2	C,F	--	26106756(+)	`CAGAAA/-GCTGG`	1	--	int¹		7		NS NA CSA	178
rs112336932^1,2	C	--	26115222(+)	`GCGTGCACA/- CACAC`	1	--	int¹		1		CSA	2
rs59431357^1,2	C,F	--	26115249(+)	`CACAC-/AC/ACAC/ACACAC ACAC/ACACACACACACGAATG`	2	--	int¹ cds¹		2		NA	4
rs34992777^1,2	C	--	26119841(+)	`CTACAA/-AAAAA`	1	--	int¹		1		NA	2
rs28998799^1,2	C,F	--	26126131(-)	`GGGGGG/-TTCAT`	1	--	int¹		6		NS NA	184
rs35834812^1,2	C	--	26126817(+)	`AAAAA-/AGAAAG`	1	--	int¹		1		NA	2
rs146226023^1,2		--	26143243(+)	`TCCTTA/GGCCTG`	1	--	ds500¹		0	--	--	--	--
rs115428634^1,2	F	--	26143250(+)	`CCTGCT/ACCAAA`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for NOS2 (26083792 - 26127555 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for NOS2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2715781	CNV	Deletion	23290073
nsv9533	CNV	Gain	18304495
esv28579	CNV	Gain	19812545
dgv943e1	CNV	Complex	17122850

Human Gene Mutation Database (HGMD): NOS2

Locus Specific Mutation Databases (LSDB): NOS2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOS2

DNA2.0 Custom Variant and Variant Library Synthesis for NOS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 163730
OMIM disorders: 145500  611162
20/358 diseases for NOS2 (see all 358):    About MalaCards

virilizing ovarian tumor pityriasis lichenoides bladder carcinoma in situ borderline leprosy

peyronie's disease peyronies disease collagenous colitis trigonitis

lymphocytic colitis internal hemorrhoid cytokine receptor deficiency hemorrhoid

warthin tumor idiopathic achalasia myocarditis colonic disease

retinal vasculitis lip cancer microscopic colitis choledochal cyst

3 diseases from the University of Copenhagen DISEASES database for NOS2:

Vascular disease Gastrointestinal system disease Arthritis

NOS2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

96 Novoseek inferred disease relationships for NOS2 gene (see top 10) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	76.7	531	14657339 (3), 17449036 (3), 16537027 (3), 12613978 (3) (see all 99)
necrosis	75.9	590	16827641 (4), 17452936 (3), 9856818 (3), 10713108 (3) (see all 99)
tumors	64.1	1265	11156233 (6), 17980097 (6), 16557582 (5), 20338478 (5) (see all 99)
shock septic	63.8	96	7536056 (4), 12594864 (3), 14654318 (3), 10791377 (3) (see all 58)
sepsis	54.4	152	12016107 (5), 17997414 (4), 12594864 (3), 10669117 (3) (see all 72)
atherosclerosis	51.8	77	8683942 (3), 10073969 (3), 10334927 (2), 11139364 (2) (see all 47)
neurodegenerative diseases	50.5	18	16144552 (1), 7523410 (1), 11246231 (1), 16807879 (1) (see all 11)
inflammatory bowel diseases	46.6	44	17955236 (2), 12792224 (2), 10102942 (1), 10630438 (1) (see all 28)
cell damage	46.4	28	11218753 (2), 9377819 (1), 11139364 (1), 11488434 (1) (see all 22)
ischemia	46.1	102	15327760 (4), 16154689 (4), 11708836 (3), 8787213 (3) (see all 61)
colitis	45.7	61	19238344 (4), 16165717 (4), 19285099 (4), 11282554 (3) (see all 28)
shock endotoxic	43.6	9	7536934 (1), 9628258 (1), 11292370 (1), 9556848 (1) (see all 6)
shock	43.6	93	16937286 (3), 14654318 (2), 8751576 (2), 10385249 (2) (see all 66)
vascular diseases	43.5	24	12504936 (2), 10779466 (1), 15051034 (1), 15542378 (1) (see all 13)
lymphoma t-cell peripheral	43	12	16124164 (1), 12166895 (1), 19031731 (1), 17582237 (1) (see all 12)
peyronie disease	42.6	13	12454685 (2), 12446175 (1), 12009846 (1), 14996430 (1) (see all 7)
neurodegeneration	42.1	24	16165295 (2), 11240010 (2), 11324986 (1), 11689164 (1) (see all 15)
osteoarthritis	41	27	12856254 (2), 9236674 (2), 9870873 (2), 10419769 (1) (see all 17)
invasive ductal breast carcinoma	39.7	5	9012463 (1), 15883814 (1), 11592099 (1), 9651946 (1) (see all 5)
hypertension pulmonary	39.5	30	11371423 (3), 12904860 (2), 16169754 (2), 9486205 (1) (see all 19)
cardiovascular diseases	39.2	34	19463074 (3), 9703761 (2), 12233810 (2), 7546624 (1) (see all 21)
erectile dysfunction	38.5	12	9096878 (4), 11781741 (1), 16507050 (1), 9631946 (1) (see all 9)
malaria cerebral	38.5	16	10971704 (3), 12552317 (3), 15960706 (2), 19153766 (1) (see all 8)
gastritis	37.3	51	10348815 (5), 11267845 (5), 14760971 (4), 9926291 (3) (see all 21)
pathological processes	36.6	18	14599552 (1), 16540395 (1), 11553314 (1), 18287515 (1) (see all 11)
hypotension	36.2	37	9628258 (2), 7536934 (1), 9118670 (1), 9892267 (1) (see all 28)
colitis ulcerative	34.5	57	10901620 (6), 9771406 (4), 8831582 (3), 15753535 (3) (see all 31)
multiple sclerosis	32.2	36	15145615 (3), 9506556 (2), 9665945 (2), 11395383 (2) (see all 19)
rheumatoid arthritis	31.7	47	12826065 (3), 12621554 (2), 12140750 (2), 10614169 (2) (see all 27)
alzheimers disease	31.7	41	12384247 (3), 10789135 (2), 11556547 (2), 8879214 (2) (see all 23)
carcinoma ductal	30.5	43	8861838 (3), 8958553 (2), 7909010 (2), 20174726 (2) (see all 28)
cerebral vasospasm	29.9	6	17977265 (2), 18590437 (1), 12233810 (1), 18807216 (1)
adenocarcinoma	29.9	110	10970689 (4), 9679948 (3), 11373104 (3), 9921950 (2) (see all 69)
collagenous colitis	29.9	7	16957516 (2), 11511561 (2), 12229970 (1), 15641395 (1)
periapical granuloma	29.8	7	16507070 (2), 17258631 (2), 19037921 (1)
chromosome 8 trisomy	29.7	1	9283590 (1)
vasospasm	29.6	12	17369785 (2), 17053178 (2), 8875487 (1), 12800488 (1) (see all 9)
aids dementia complex	28.4	3	10199221 (1)
heart failure	28.3	111	16803456 (6), 15366433 (5), 8653828 (4), 9851365 (3) (see all 44)
astrocytoma	27.8	46	11866952 (4), 15088099 (4), 16724682 (4), 9223073 (2) (see all 21)
cancer	27.3	220	19875457 (5), 10331487 (4), 12374680 (3), 19164562 (3) (see all 99)
nasal polyps	27	56	15362679 (5), 9515595 (4), 8777951 (3), 15490564 (3) (see all 16)
breast carcinoma	26.9	38	10873093 (4), 1332483 (3), 1701960 (3), 9012463 (2) (see all 22)
diabetes autoimmune	26.6	2	8594615 (1), 9375806 (1)
cerebral ischemia	25.7	36	10079976 (2), 15228594 (2), 16395420 (2), 8875487 (1) (see all 17)
colon cancer	25.7	32	19925669 (4), 16216410 (2), 9443414 (2), 15476855 (2) (see all 20)
hyperplasia	25.7	58	16552960 (4), 9740187 (3), 15694929 (3), 11819093 (2) (see all 26)
encephalomyelitis	25.4	14	9510198 (2), 9762676 (1), 15856071 (1), 12203391 (1) (see all 10)
acute respiratory distress	25.2	4	11179131 (1), 20477340 (1), 20388761 (1)
airways disease	24.9	4	17979023 (1), 7546629 (1), 10767722 (1)
glomerulosclerosis, focal segmental	24.7	2	10198566 (1), 17021605 (1)
carcinoma	24.6	173	19701111 (7), 11930727 (4), 11956620 (4), 17663360 (3) (see all 81)
arthritis	24.5	48	14719189 (3), 12826065 (3), 12672181 (3), 8991992 (2) (see all 25)
adenoma basal cell	24.4	2	9684573 (1), 8986967 (1)
liposarcoma pleomorphic	24.3	1	20305534 (1)
adenoma pleomorphic	23.6	16	10890559 (6), 19799816 (2), 9684573 (1), 15880136 (1) (see all 10)
asthma	23.4	117	8680689 (4), 18341205 (4), 17189532 (4), 12974195 (3) (see all 57)
multiple organ failure	23	2	14556720 (1), 9444610 (1)
encephalitis	23	11	11282169 (2), 9951625 (1), 7491773 (1), 10320031 (1) (see all 6)
shock hemorrhagic	21.8	22	10353536 (5), 7537167 (2), 12578118 (2), 7678341 (1) (see all 9)
brain diseases	21.8	5	10395902 (1), 7530762 (1), 19519641 (1)
associated conditions	21.5	7	11532247 (1), 8842429 (1), 11282169 (1), 8779963 (1) (see all 5)
glioma	21.3	75	12617238 (4), 15683746 (4), 11693258 (4), 19629394 (3) (see all 34)
glomerulonephritis	21.1	30	12454221 (5), 10589693 (3), 1280702 (2), 7573358 (2) (see all 14)
preeclampsia	21	57	8743168 (5), 11327094 (4), 11166745 (4), 19776611 (4) (see all 21)
immunopathology	19.6	1	11748285 (1)
carcinoma adenoid cystic	19.3	12	16243805 (2), 15584054 (1), 19574086 (1), 8986967 (1) (see all 10)
salivary gland adenocarcinoma	19.3	1	7684204 (1)
carcinoma mucoepidermoid	19.3	8	9684573 (1), 15880136 (1), 16996786 (1), 7684204 (1) (see all 7)
respiratory distress syndrome	18.4	4	11179131 (1), 20477340 (1), 20388761 (1)
senile plaques	18.1	6	10560659 (2), 11716809 (1), 19660523 (1), 15571982 (1) (see all 5)
uremia	17.8	4	8734457 (2), 9029246 (1)
supraglottic squamous cell carcinoma	17.7	4	12508542 (2), 12969533 (1)
renal disease	17.2	26	17070441 (2), 7546625 (2), 9607210 (1), 11267247 (1) (see all 19)
metastasis	17.1	116	10188914 (4), 11400148 (3), 9237172 (3), 12943630 (3) (see all 63)
carcinoma squamous cell	16.8	87	16552960 (4), 12369071 (4), 12452003 (4), 10339659 (4) (see all 43)
myoepithelioma	16.7	2	8986967 (1), 9471611 (1)
occlusion middle cerebral artery	16.1	4	15228594 (2)
malignant fibrous histiocytoma	16	6	15702318 (2), 20368975 (1), 20464676 (1), 1309926 (1) (see all 5)
lymphocytic leukemia chronic b-cell	15.7	4	14574328 (1), 17642141 (1), 18474259 (1), 9680373 (1)
diabetic retinopathy	15.4	10	10506586 (2), 9292247 (1), 17337232 (1), 18065828 (1) (see all 7)
neovascularization	14.6	2	9921950 (1), 9846573 (1)
hypercholesterolemia	14.5	8	19505368 (2), 10377069 (1), 15524164 (1), 16228201 (1) (see all 7)
mpnst	13.9	1	11554386 (1)
demyelination	13.9	10	15145615 (1), 10190690 (1), 10494107 (1), 9058833 (1) (see all 7)
renal ischemia	13.9	4	16540395 (2), 11849438 (1), 16495814 (1)
glomerulosclerosis	13.8	4	10198566 (1), 8743536 (1), 15855741 (1)
hyperglycemia	13.7	22	15855318 (4), 17804300 (3), 19539448 (2), 15479219 (2) (see all 11)
edema	13.7	34	11245273 (2), 8799551 (2), 18854985 (2), 15015560 (1) (see all 17)
myocardial ischemia	13.6	30	9545547 (1), 9689595 (1), 11708836 (1), 12702642 (1) (see all 16)
gastritis chronic	13	4	9802453 (2), 15191513 (1), 19077474 (1)
malaria falciparum	12.9	9	12888113 (1), 12716455 (1), 17543124 (1), 9764323 (1) (see all 7)
carcinoma lobular	12.9	10	15365566 (1), 2173410 (1), 8861838 (1), 1346789 (1) (see all 7)
glioblastoma	12.8	20	8742473 (2), 10769671 (2), 10369188 (1), 14676405 (1) (see all 12)
myocarditis	12.8	12	8978317 (4), 9244230 (4), 11901182 (1), 7568904 (1)
asthma allergic	12.7	5	8590967 (1), 10556950 (1), 9655713 (1), 10330441 (1) (see all 5)

Genetic Association Database (GAD): NOS2
Human Genome Epidemiology (HuGE) Navigator: NOS2 (192 documents)

Export disorders for NOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NOS2 gene, integrated from 9 sources (see all 4083):
(articles sorted by number of sources associating them with NOS2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. (PubMed id 7682706)^{1, 2, 3, 9} Geller D.A....Billiar T.R. (1993)
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (PubMed id 12433515)^{1, 2, 4, 9} Hobbs M.R....Weinberg J.B. (2002)
Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. (PubMed id 9160867)^{1, 2, 9} Luss H.... Billiar T.R. (1997)
Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis. (PubMed id 19327239)^{1, 4, 9} Gonzalez-Gay M.A....Martin J. (2009)
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. (PubMed id 19859740)^{1, 4, 9} Levesque M.C....Weinberg J.B. (2010)
Role of inducible nitric oxide synthase in asthma ris k and lung function growth during adolescence. (PubMed id 19996333)^{1, 4, 9} Islam T....Gilliland F.D. (2010)
The CCTTT pentanucleotide microsatellite in iNOS promoter influences the clinical outcome in P. falciparum infection. (PubMed id 19153766)^{1, 4, 9} Dhangadamajhi G....Ranjit M.R. (2009)
Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. (PubMed id 19242068)^{1, 4, 9} Bohanec Grabar P....Dolzan V. (2009)
NO role of NOS2A susceptibility polymorphisms in rheu matoid arthritis. (PubMed id 19635578)^{1, 4, 9} VaradAc J....Urcelay E. (2009)
Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. (PubMed id 10409685)^{1, 2, 9} Li H.... Poulos T.L. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4843	HGNC: 7873	AceView: NOS2A	Ensembl:ENSG00000007171	euGenes: HUgn4843
ECgene: NOS2	Kegg: 4843	H-InvDB: NOS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NOS2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/nos2a/
Wikipedia	http://en.wikipedia.org/wiki/Nitric_oxide_synthase

Intellectual Property for NOS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NOS2 gene:
Search GeneIP for patents involving NOS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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NOS2 Gene

Nitric Oxide Synthase 2, Inducible

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NOS2 Gene

Nitric Oxide Synthase 2, Inducible

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