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NOS2 Gene

protein-coding   GIFtS: 67
GCID: GC17M026083

Nitric Oxide Synthase 2, Inducible

(Previous names: nitric oxide synthase 2A (inducible, hepatocytes))
(Previous symbol: NOS2A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nitric Oxide Synthase 2, Inducible1 2     NOS Type II2 3
NOS2A1 2 3 5     EC 1.14.13.393 8
Nitric Oxide Synthase 2A (Inducible, Hepatocytes)1 2     INOS2
Hepatocyte NOS2 3     NOS2
Inducible NO Synthase2 3     Nitric Oxide Synthase, Inducible2
Inducible NOS2 3     Nitric Oxide Synthase, Macrophage2
Peptidyl-Cysteine S-Nitrosylase NOS22 3     NOS, Type II2
HEP-NOS2 3     iNOS3

External Ids:    HGNC: 78731   Entrez Gene: 48432   Ensembl: ENSG000000071717   OMIM: 1637305   UniProtKB: P352283   

Export aliases for NOS2 gene to outside databases

Previous GC identifers: GC17M023108 GC17M022290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOS2 Gene:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including
neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which
is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three
related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq,
Jul 2008)

GeneCards Summary for NOS2 Gene:
NOS2 (nitric oxide synthase 2, inducible) is a protein-coding gene. Diseases associated with NOS2 include malaria, and virilizing ovarian tumor. GO annotations related to this gene include calmodulin binding and protein homodimerization activity. An important paralog of this gene is NOS3.

UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In
macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates
cysteine S-nitrosylation of cytoplasmic target proteins such COX2

summary for NOS2 Gene:
Inducible nitric oxide synthase (iNOS), along with neuronal nitric oxide synthase (nNOS) and endothelial
nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and
molecular oxygen. It displays high affinity for Ca2+/calmodulin, thus appears to be constitutively active.
Tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH co-factors are required
for catalytic activity. iNOS gene expression is regulated by various pathways including NF-kappaB, IFN-gamma
(signaling through the JAK-STAT cascade) and HIF-1, which induce expression, and TGF-beta and interleukins
-4, -10 and -13, which inhibit expression. Post-translational regulation occurs by prevention of iNOS
homodimerization by NAP110. iNOS has roles in the innate immune system and displays antibacterial, antiviral
and antifungal activity. The human gene encoding iNOS is localized to chromosome 17q11.2-q12.

Gene Wiki entry for NOS2 (Nitric oxide synthase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NOS2 gene promoter:
         p300   MyoD   IRF-1   HNF-3beta   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOS2 promoter sequence
   Search Chromatin IP Primers for NOS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2-q12

NOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M026083:  view genomic region     (about GC identifiers)

Start:
26,083,792 bp from pter      End:
26,127,555 bp from pter
Size:
43,764 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228 (See protein sequence)
Recommended Name: Nitric oxide synthase, inducible  
Size: 1153 amino acids; 131117 Da
Cofactor: Heme group (By similarity)
Cofactor: Binds 1 FAD (By similarity)
Cofactor: Binds 1 FMN (By similarity)
Cofactor: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity)
Subunit: Homodimer. Binds SLC9A3R1
Selected PDB 3D structures from and Proteopedia for NOS2 (see all 7):
1NSI (3D)        2LL6 (3D)        2NSI (3D)        3E7G (3D)        3EJ8 (3D)        3HR4 (3D)    
Secondary accessions: A1L3U5 B7ZLY2 O60757 O94994 Q16263 Q16692 Q4TTS5 Q9UD42
Alternative splicing: 2 isoforms:  P35228-1   P35228-2   

Explore the universe of human proteins at neXtProt for NOS2: NX_P35228

Explore proteomics data for NOS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NOS2 (P35228) (see all 43)
     VLEEFPS  GWYMGTE  LDITTPP  LQVFDAR 


    See NOS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000616.3  
    ENSEMBL proteins: 
     ENSP00000327251  
    Reactome Protein details: P35228

    NOS2 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for NOS2
    OriGene Purified Protein for NOS2
    OriGene Protein Over-expression Lysate for NOS2
    OriGene MassSpec for NOS2
    OriGene Custom Protein Services for NOS2
    GenScript Custom Purified and Recombinant Proteins Services for NOS2
    Novus Biologicals NOS2 Protein
    Novus Biologicals NOS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOS2

    NOS2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NOS2
    R&D Systems Antibodies for NOS2 (iNOS)
    OriGene Antibodies for NOS2
    OriGene Custom Antibody Services for NOS2
    Novus Biologicals NOS2 Antibodies
    Abcam antibodies for NOS2 (P29475, P35228)
    Cloud-Clone Corp. Antibodies for NOS2
    ThermoFisher Antibody for NOS2
    LSBio Antibodies in human, mouse, rat for NOS2

    NOS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOS2
    R&D Systems ELISAs for NOS2 (iNOS)
    GenScript Custom Assay Services for NOS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOS2
    Cloud-Clone Corp. CLIAs for NOS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Inducible NOS
    Nitric oxide synthases

    Selected InterPro protein domains (see all 10):
     IPR017927 Fd_Rdtase_FAD-bd
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR012144 NOS_euk
     IPR004030 NO_synthase_oxygenase_dom

    Graphical View of Domain Structure for InterPro Entry P35228

    ProtoNet protein and cluster: P35228

    Selected Blocks protein domains (see all 6):
    IPB001094 Flavodoxin signature
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB003097 FAD-binding
    IPB004030 Nitric oxide synthase


    UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228
    Similarity: Belongs to the NOS family
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 flavodoxin-like domain


    NOS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOS2_HUMAN, P35228
    Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In
    macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates
    cysteine S-nitrosylation of cytoplasmic target proteins such COX2
    Catalytic activity: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O
    Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and
    effects may be exerted at the level of translational/post-translational modification and directly on the
    catalytic activity (By similarity)
    Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial
    lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta

         Enzyme Number (IUBMB): EC 1.14.13.391 2

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003958NADPH-hemoprotein reductase activity IBA--
    GO:0004517nitric-oxide synthase activity IDA7504305
    GO:0005102receptor binding IPI--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI12855682
         
    NOS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOS2:
     Decreased viability after Chla  Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nos2) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    NOS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOS2: Nos2tm1Mrl Nos2tm1Lau Nos2tm1Liew

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOS2:
    hsa-mir-26a-5p (MIRT007347)

    Block miRNA regulation of human, mouse, rat NOS2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NOS2:
    hsa-miR-485-3p hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidNOS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOS2
    Predesigned siRNA for gene silencing in human, mouse, rat NOS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOS2

    Clone
    Products:
         
    OriGene clones in human, mouse for NOS2 (see all 6)
    OriGene ORF clones in mouse, rat for NOS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol3
    nucleus3
    cytoskeleton2
    extracellular2
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA7544003
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA12085352
    GO:0005777peroxisome IDA12085352
    GO:0005829cytosol TAS--

    NOS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOS2 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Arginine and proline metabolism
    Arginine and proline metabolism
    citrulline-nitric oxide cycle0.00
    superpathway of citrulline metabolism0.00
    2IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Bacterial infections in CF airways0.78
    4Leishmaniasis
    Leishmaniasis0.35
    Toxoplasmosis0.35
    5Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NOS2 (see all 10)
        MIF Regulation of Innate Immune Cells
    MSP-RON Signaling
    Sertoli-Sertoli Cell Junction Dynamics
    Endothelin-1 Signaling Pathway
    Relaxin Pathway

    Selected GeneGo (Thomson Reuters) Pathways for NOS2 (see all 11)
        Immune response MIF-mediated glucocorticoid regulation
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

    Selected BioSystems Pathways for NOS2 (see all 12)
        Type II interferon signaling (IFNG)
    AGE/RAGE pathway
    Spinal Cord Injury
    Effects of nitric oxide
    citrulline-nitric oxide cycle

    2 Reactome Pathways for NOS2
        Phagosomal maturation (early endosomal stage)
    Nitric oxide stimulates guanylate cyclase

    2 PharmGKB Pathways for NOS2
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for NOS2) (see all 14):
        Arginine and proline metabolism
    Metabolic pathways
    Calcium signaling pathway
    HIF-1 signaling pathway
    Peroxisome


    NOS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOS2 (see all 14): 
              Insulin Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOS2 (P352283 ENSP000003272514) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM3P621583I2D: score=1 
    ACTN4O437073, ENSP000002526994I2D: score=4 STRING: ENSP00000252699
    RAC2P151533, ENSP000002490714I2D: score=4 STRING: ENSP00000249071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001912positive regulation of leukocyte mediated cytotoxicity TAS10450191
    GO:0002227innate immune response in mucosa NAS18390757
    GO:0006527arginine catabolic process IDA7504305
    GO:0006801superoxide metabolic process ISS--

    NOS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NOS2
      Browse compounds at ApexBio 

    Compounds for NOS2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BYK 191023 dihydrochloridePotent and selective inhibitor of iNOS[608880-48-4]
    L-NIL hydrochlorideSelective iNOS inhibitor[150403-89-7]
    1400W dihydrochloride Potent, highly selective iNOS inhibitor [180001-34-7]
    AMT hydrochloride Potent, selective iNOS inhibitor [21463-31-0]
    (S)-Methylisothiourea sulfateHighly selective iNOS inhibitor[867-44-7]

    10 HMDB Compounds for NOS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Citrulline(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)372-75-8--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Nitric oxideMononitrogen monoxide (see all 9)10102-43-9--
    Tetrahydrobiopterin(1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol (see all 11)17528-72-2--

    Selected DrugBank Compounds for NOS2 (see all 40)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17513447 17340133 16778961 17362916 17363779
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--12745988 10906994 11742852 10906995 10944418
    Aminoguanidine-- 79-17-4targetinhibitor17139284 11752352 17016423 10592235
    DexamethasoneDesametasone (see all 9)50-02-2targetnegative modulator17494951 17503181 11752352 17379310
    Miconazole-- 22916-47-8targetinhibitor7536941 7518297 7683652 9873034
    Triflusal-- --targetagonist9551715 19465361 16939630 10998082
    3-Bromo-7-Nitroindazole-- --target--17139284 17016423 10592235
    4r-Fluoro-N6-Ethanimidoyl-L-Lysine-- --target--17139284 17016423 10592235
    5-Nitroindazole-- --target--17139284 17016423 10592235
    6-Nitroindazole-- --target--17139284 17016423 10592235

    5 IUPHAR Ligands for NOS2 (Inducible NOS)    About this table
    LigandTypeActionAffinityPubmed IDs
    1400W
    InhibitorInhibition8.29030556
    2-amino-4-methylpyridine
    InhibitorInhibition7.48937711
    PIBTU
    InhibitorInhibition7.37523409
    NIL
    InhibitorInhibition5.57525961
    aminoguanidine
    InhibitorInhibition5.51378415

    Selected Novoseek inferred chemical compound relationships for NOS2 gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 97.5 18892 11680730 (10), 11342896 (8), 16957516 (8), 18554637 (8) (see all 99)
    citrulline 87.5 279 20148434 (3), 20148433 (3), 8561501 (3), 7527657 (2) (see all 99)
    l-nmma 87.3 488 9503327 (4), 12810424 (3), 17724209 (3), 18090547 (3) (see all 99)
    arginine 86.4 1048 16245240 (5), 11275358 (5), 8639550 (5), 7664438 (4) (see all 99)
    peroxynitrite 86.2 233 11788351 (4), 9180331 (3), 10383909 (3), 9122229 (3) (see all 99)
    aminoguanidine 84.9 363 9538001 (5), 16553284 (4), 18790185 (4), 11062159 (3) (see all 99)
    adma 83.5 234 8743168 (5), 15325021 (4), 19682580 (4), 10802528 (3) (see all 99)
    tetrahydrobiopterin 79.4 94 15565652 (2), 14609340 (2), 16052472 (2), 16172396 (2) (see all 67)
    cgmp 78.8 303 18606420 (5), 10802528 (4), 11181408 (4), 8633049 (4) (see all 99)
    n(g)-nitro-l-arginine methyl ester 76.8 176 11891189 (2), 7684763 (1), 7673269 (1), 8991992 (1) (see all 99)



    NOS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOS2 gene (2 alternative transcripts): 
    NM_000625.4  NM_153292.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313735(uc002gzu.3 uc010wab.1 uc010crh.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOS2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NOS2:
    hsa-miR-485-3p hsa-miR-323-5p
    SwitchGear 3'UTR luciferase reporter plasmidNOS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOS2
    Predesigned siRNA for gene silencing in human, mouse, rat NOS2
    Clone
    Products:
         
    OriGene clones in human, mouse for NOS2 (see all 6)
    OriGene ORF clones in mouse, rat for NOS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOS2 (NM_000625)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOS2
      QuantiTect SYBR Green Assays in human, mouse, rat NOS2
      QuantiFast Probe-based Assays in human, mouse, rat NOS2

    Selected AceView cDNA sequences (see all 75):

    NM_153292 AW445097 S75615 S76479 BM834810 AW297448 BE073577 NM_000625 
    X73029 BE073638 AI797675 AW449618 AI953734 AI738789 CD609259 AI991263 
    L24553 U31511 CD609257 BV207664 BV188741 AA877840 CD609248 H67843 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOS2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                    -                                                                                                                                       
    SP2:                    -                                                                                                                                       
    SP3:                                      -                                                                                                                     

    ExUns: 26 ^ 27 ^ 28
    SP1:                  
    SP2:                  
    SP3:                  


    ECgene alternative splicing isoforms for NOS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGCATTT
    NOS2 Expression
    About this image


    NOS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced 4D20.8 cells
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced 4D20.8 cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Brain (Nervous System)
             N2/LSB induced-cells
    NOS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOS2 Protein Expression

    UniProtKB/Swiss-Prot: NOS2_HUMAN, P35228
    Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not
    expressed in the platelets

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOS2 (see all 14): 
              Insulin Signaling Pathway in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOS2
    QuantiTect SYBR Green Assays in human, mouse, rat NOS2
    QuantiFast Probe-based Assays in human, mouse, rat NOS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NOS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nos21 , 5 nitric oxide synthase 2, inducible1, 5 82.4(n)1
    81.21(a)1
      11 (46.74 cM)5
    181261  NM_010927.31  NP_035057.11 
     789207875 
    chicken
    (Gallus gallus)
    Aves NOS21 nitric oxide synthase 2, inducible 68.43(n)
    70.46(a)
      395807  NM_204961.1  NP_990292.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOS26
    nitric oxide synthase 2, inducible
    56(a)
    1 ↔ 1
    GL343729.1(116369-178014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nos21 nitric oxide synthase 2, inducible 65.96(n)
    65.96(a)
      100494698  XM_002935296.2  XP_002935342.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nos2b1 nitric oxide synthase 2b, inducible 61.56(n)
    60.63(a)
      563654  NM_001113501.1  NP_001106973.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nos6
    Nitric oxide synthase
    38(a)
    1 → many
    2L(10804269-10838448)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NCP16
    NADP-cytochrome P450 reductase; involved in ergost...
    24(a)
    1 → many
    VIII(190543-192618) YHR042W


    ENSEMBL Gene Tree for NOS2 (if available)
    TreeFam Gene Tree for NOS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOS2 gene
    NOS32  POR2  MTRR2  NOS12  
    2 SIMAP similar genes for NOS2 using alignment to 1 protein entry:     NOS2_HUMAN:
    NOS1    NOS3

    NOS2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for NOS2 (see all 15)
    PGOHUM00000247699 PGOHUM00000248028 PGOHUM00000250807 PGOHUM00000237000 PGOHUM00000237005


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NOS2_HUMAN, P35228: Note=Genetic variations in NOS2 are involved in resistance to malaria [MIM:611162]


    Selected SNPs for NOS2 (see all 1440)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363024
    A breast cancer sample4--see VAR_0363022 A S mis40--------
    rs596857461,2
    C--26088338(+) CACGG-/CCCTCC 1 -- int13Minor allele frequency- C:0.00NA CSA 8
    rs58198211,2
    C,F--26106756(+) CAGAAA/-GCTGG 1 -- int17Minor allele frequency- -:0.31NS NA CSA 178
    rs1123369321,2
    C--26115222(+) GCGTGCACA/-  
            
    CACAC
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs594313571,2
    C,F--26115249(+) CACAC-/AC/ACAC/ACACAC
    ACAC
    /ACACACACACAC
    GAATG
    2 -- int1 cds12NA 4
    rs349927771,2
    C--26119841(+) CTACAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs289987991,2
    C,F--26126131(-) GGGGGG/-TTCAT 1 -- int16Minor allele frequency- -:0.07NS NA 184
    rs358348121,2
    C--26126817(+) AAAAA-/AGAAAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1462260231,2
    --26143243(+) TCCTTA/GGCCTG 1 -- ds50010--------
    rs1154286341,2
    F--26143250(+) CCTGCT/ACCAAA 1 -- ds50011Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for NOS2 (26083792 - 26127555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NOS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715781CNV Deletion23290073
    nsv9533CNV Gain18304495
    esv28579CNV Gain19812545
    dgv943e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NOS2
    Locus Specific Mutation Databases (LSDB): NOS2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOS2
    DNA2.0 Custom Variant and Variant Library Synthesis for NOS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 163730   
    OMIM disorders: 145500  611162  
    Selected diseases for NOS2 (see all 366):    
    About MalaCards
    malaria    virilizing ovarian tumor    pityriasis lichenoides    bladder carcinoma in situ
    borderline leprosy    hypertension    peyronie's disease    collagenous colitis
    peyronies disease    trigonitis    internal hemorrhoid    cytokine receptor deficiency
    hemorrhoid    lymphocytic colitis    lip cancer    idiopathic achalasia
    myocarditis    colonic disease    retinal vasculitis    warthin tumor

    3 diseases from the University of Copenhagen DISEASES database for NOS2:
    Vascular disease     Gastrointestinal system disease     Arthritis

    NOS2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NOS2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 76.7 531 14657339 (3), 17449036 (3), 16537027 (3), 12613978 (3) (see all 99)
    necrosis 75.9 590 16827641 (4), 17452936 (3), 9856818 (3), 10713108 (3) (see all 99)
    tumors 64.1 1265 11156233 (6), 17980097 (6), 16557582 (5), 20338478 (5) (see all 99)
    shock septic 63.8 96 7536056 (4), 12594864 (3), 14654318 (3), 10791377 (3) (see all 58)
    sepsis 54.4 152 12016107 (5), 17997414 (4), 12594864 (3), 10669117 (3) (see all 72)
    atherosclerosis 51.8 77 8683942 (3), 10073969 (3), 10334927 (2), 11139364 (2) (see all 47)
    neurodegenerative diseases 50.5 18 16144552 (1), 7523410 (1), 11246231 (1), 16807879 (1) (see all 11)
    inflammatory bowel diseases 46.6 44 17955236 (2), 12792224 (2), 10102942 (1), 10630438 (1) (see all 28)
    cell damage 46.4 28 11218753 (2), 9377819 (1), 11139364 (1), 11488434 (1) (see all 22)
    ischemia 46.1 102 15327760 (4), 16154689 (4), 11708836 (3), 8787213 (3) (see all 61)

    Genetic Association Database (GAD): NOS2
    Human Genome Epidemiology (HuGE) Navigator: NOS2 (192 documents)

    Export disorders for NOS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOS2 gene, integrated from 10 sources (see all 4100) (see top 10):
    (articles sorted by number of sources associating them with NOS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. (PubMed id 7682706)1, 2, 3, 9 Geller D.A....Billiar T.R. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (PubMed id 12433515)1, 2, 4, 9 Hobbs M.R.... Weinberg J.B. (Lancet 2002)
    3. Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS. (PubMed id 9160867)1, 2, 9 Luss H.... Billiar T.R. (J. Mol. Cell. Cardiol. 1997)
    4. Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis. (PubMed id 19327239)1, 4, 9 Gonzalez-Gay M.A....Martin J. (Clin. Exp. Rheumatol. 2009)
    5. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. (PubMed id 19996333)1, 4, 9 Islam T....Gilliland F.D. (Thorax 2010)
    6. Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. (PubMed id 19859740)1, 4, 9 Levesque M.C....Weinberg J.B. (Hum. Genet. 2010)
    7. The CCTTT pentanucleotide microsatellite in iNOS promoter influences the clinical outcome in P. falciparum infection. (PubMed id 19153766)1, 4, 9 Dhangadamajhi G....Ranjit M.R. (Parasitol. Res. 2009)
    8. Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. (PubMed id 19242068)1, 4, 9 Bohanec Grabar P....Dolzan V. (Dis. Markers 2009)
    9. NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis. (PubMed id 19635578)1, 4, 9 VaradAc J....Urcelay E. (Nitric Oxide 2009)
    10. Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. (PubMed id 10409685)1, 2, 9 Li H.... Poulos T.L. (J. Biol. Chem. 1999)
    11. Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172. (PubMed id 7531687)1, 2, 9 Hokari A.... Esumi H. (J. Biochem. 1994)
    12. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. (PubMed id 7692964)1, 2, 9 Sherman P.A.... Wood E.R. (Biochemistry 1993)
    13. EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity. (PubMed id 20028935)1, 4 Darrah R....Drumm M.L. (Physiol. Genomics 2010)
    14. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    15. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PubMed id 20953189)1, 4 Stuart P.E....Elder J.T. (Nat. Genet. 2010)
    16. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. (PubMed id 19395279)1, 4 Bagarolli R.A....Saad S.T. (J. Diabetes Complicat. 2010)
    17. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (Hum. Genet. 2009)
    18. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    19. Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease. (PubMed id 19624767)1, 4 Yoneda M....Nakajima A. (Hepatol. Res. 2009)
    20. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. ( a journal of cerebral circulation 2009)
    21. Role of inflammation gene polymorphisms on pain severity in lung cancer patients. (PubMed id 19773451)1, 4 Reyes-Gibby C.C....Shete S. (amp 2009)
    22. Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy. (PubMed id 19286578)1, 4 Yocum G.T....Heyer E.J. ( a journal of cerebral circulation 2009)
    23. Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors. (PubMed id 19505917)1, 4 Bhatti P....Rajaraman P. (amp 2009)
    24. Genetic variation in neuronal nitric oxide synthase (nNOS) gene and susceptibility to cerebral malaria in Indian adults. (PubMed id 19540363)1, 4 Dhangadamajhi G....Ranjit M. (Infect. Genet. Evol. 2009)
    25. Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease. (PubMed id 19309520)1, 4 Payton A....Carrol E.D. (BMC Med. Genet. 2009)
    26. Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis. (PubMed id 19225544)1, 4 McDougal K.E....Cutting G.R. (J. Invest. Dermatol. 2009)
    27. Functional single nucleotide polymorphism-1026C/A of inducible nitric oxide synthase gene with increased YY1-binding affinity is associated with hypertension in a Chinese Han population. (PubMed id 19402223)1, 4 Fu L....Li Y. (J. Hypertens. 2009)
    28. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    29. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    30. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PubMed id 19479237)1, 4 Song X.Y....Chan J.C. (Diabetologia 2009)
    31. A candidate gene association study of 77 polymorphisms in migraine. (PubMed id 19559392)1, 4 SchA1rks M....Zee R.Y. (J Pain 2009)
    32. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. (PubMed id 19263529)1, 4 Zee R.Y....Glynn R.J. ( international journal of clinical chemistry 2009)
    33. Genetic variation of polymorphic NOS STR locus in ten Indian population groups. (PubMed id 19334623)1, 4 Shazia A....Seshadri M. (Genetika 2009)
    34. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. (PubMed id 19723394)1, 4 Velez D.R....Scott W.K. (Int. J. Tuberc. Lung Dis. 2009)
    35. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    36. Suggested association of NOS2A polymorphism in idiopathic achalasia: no evidence in a large case-control study. (PubMed id 19337240)1, 4 Vigo A.G....Ruiz de LeA^n A. (Am. J. Gastroenterol. 2009)
    37. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PubMed id 19667218)1, 4 Comabella M....Montalban X. (Arch. Neurol. 2009)
    38. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    39. Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. (PubMed id 19423521)1, 4 Han X....Zhang Y. (amp 2009)
    40. Nitric oxide synthase gene polymorphisms and prostate cancer risk. (PubMed id 19168583)1, 4 Lee K.M....Hayes R.B. (Carcinogenesis 2009)
    41. Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population. (PubMed id 19147409)1, 4 MAPller M....Hoal E.G. (Tuberculosis (Edinb) 2009)
    42. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    43. Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis. (PubMed id 18974840)1, 4 Atik B....Dean D. (PLoS ONE 2008)
    44. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    45. Candidate genes and cerebral palsy: a population-based study. (PubMed id 18977990)1, 4 Gibson C.S....Nelson K.B. (Pediatrics 2008)
    46. TNFA locus is associated with beta degrees 39 thalassemia in Corsica and Sardinia. (PubMed id 19103526)1, 4 Giovannoni L. (Eur. Cytokine Netw. 2008)
    47. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    48. Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output. (PubMed id 12080081)1, 2 Glynne P.A.... Evans T.J. (J. Biol. Chem. 2002)
    49. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. (PubMed id 10074942)1, 2 Fischmann T.O....Weber P.C. (Nat. Struct. Biol. 1999)
    50. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. (PubMed id 7558036)1, 2 Bloch K.D.... Bloch D.B. (Genomics 1995)
    51. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. (PubMed id 7544004)1, 2 Guo F.H....Erzurum S.C. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    52. Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. (PubMed id 7522054)1, 2 Maier R.... Lotz M. (Biochim. Biophys. Acta 1994)
    53. Nitric oxide production by human proximal tubular cells: a novel immunomodulatory mechanism? (PubMed id 7532248)1, 2 McLay J.S....Hawksworth G.M. (Kidney Int. 1994)
    54. Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA. (PubMed id 7528017)1, 2 Park C.S.... Krishna G. (Biochem. Biophys. Res. Commun. 1994)
    55. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. (PubMed id 7504305)1, 2 Charles I.G.... Moncada S. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    56. Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors. (PubMed id 15601772)1, 9 Kolodziejski P.J....Eissa N.T. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    57. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. (PubMed id 12533668)1, 9 Ekmekcioglu S....Grimm E.A. (Mol. Cancer Ther. 2003)
    58. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. (PubMed id 15695237)1, 9 Nosho K....Imai K. (Carcinogenesis 2005)
    59. Expression of inducible nitric oxide synthase is significantly correlated with expression of vascular endothelial growth factor and dendritic cell infiltration in patients with advanced gastric carcinoma. (PubMed id 16020977)1, 9 Yamaguchi K....Tsujitani S. (Oncology 2005)
    60. Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. (PubMed id 16243805)1, 9 Zhang J....Chen X. (Clin. Cancer Res. 2005)
    61. Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells. (PubMed id 15242984)1, 9 Xia Y. and Krukoff T.L. (Endocrinology 2004)
    62. Expression of inducible nitric oxide synthase in human heart failure. (PubMed id 8653828)1, 9 Haywood G.A....Fowler M.B. (Circulation 1996)
    63. Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. (PubMed id 18567618)1, 9 Takahashi M....Wakabayashi K. (Carcinogenesis 2008)
    64. Binding of CAP70 to inducible nitric oxide synthase and implications for the vectorial release of nitric oxide in polarized cells. (PubMed id 17507652)1, 9 Navarro-LAcrida I....RodrA-guez-Crespo I. (Mol. Biol. Cell 2007)
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    71. Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. (PubMed id 19039588)1, 9 Johansson C.C....Kiessling R. (Cancer Immunol. Immunother. 2009)
    72. Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes. (PubMed id 18313411)1, 9 Kim H.S....Billiar T.R. (Nitric Oxide 2008)
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    75. Src-mediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase. (PubMed id 16116474)1, 9 Hausel P....Felley-Bosco E. (Oncogene 2006)
    76. Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: is there any correlation with angiogenesis or clinicopathologic parameters? (PubMed id 16681724)1, 9 Ozel E....Karaveli F.S. (Int. J. Gynecol. Cancer 2006)
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    79. Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. (PubMed id 15222024)1, 9 Li H.L....Ma F.C. (World J. Gastroenterol. 2004)
    80. Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. (PubMed id 12578118)1, 9 Collins J.L....Billiar T.R. (Shock 2003)
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    82. Ubiquitination of inducible nitric oxide synthase is required for its degradation. (PubMed id 12221289)1, 9 Kolodziejski P.J....Eissa N.T. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    83. Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features. (PubMed id 11978184)1, 9 Feng C.W....Xie X.J. (BMC Cancer 2002)
    84. Inducible nitric oxide synthase gene promoter polymorphism is associated with increased gastric mRNA expression of inducible nitric oxide synthase and increased risk of gastric carcinoma. (PubMed id 17272999)1, 9 Kaise M....Tajiri H. (amp 2007)
    85. NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. (PubMed id 19317804)1, 9 Zhang J. and Peng B. (Cell Prolif. 2009)
    86. Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. (PubMed id 17693978)1, 9 Maes M....Bosmans E. (Neuro Endocrinol. Lett. 2007)
    87. Regulation of inducible nitric oxide synthase in proinflammatory cytokine-stimulated human primary astrocytes. (PubMed id 15683721)1, 9 Jana M....Pahan K. (amp 2005)
    88. Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: correlation with tumor angiogenesis. (PubMed id 19497798)1, 9 Cianchi F....Masini E. (Dig Liver Dis 2010)
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    90. Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. (PubMed id 17404026)1, 9 Lee T.S....Song Y.S. (Ann. N. Y. Acad. Sci. 2007)
    91. Tumor iNOS predicts poor survival for stage III melanoma patients. (PubMed id 16557582)1, 9 Ekmekcioglu S....Grimm E.A. (Int. J. Cancer 2006)
    92. Contribution of inducible nitric oxide synthase and cyclooxygenase-2 to apoptosis induction in smooth chorion trophoblast cells of human fetal membrane tissues. (PubMed id 16442500)1, 9 Yuan B....Toyoda H. (Biochem. Biophys. Res. Commun. 2006)
    93. Significance of vascular endothelial growth factor expression and its correlation with inducible nitric oxide synthase in gastric cancer. (PubMed id 15112337)1, 9 Song Z.Y....Qian K.D. (World J. Gastroenterol. 2004)
    94. Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2. (PubMed id 18029351)1, 9 Xu L....Wu T. (J. Biol. Chem. 2008)
    95. Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. (PubMed id 18502573)1, 9 Sawa T....Ohshima H. (Cancer Lett. 2008)
    96. Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. (PubMed id 17189532)1, 9 Batra J....Ghosh B. (Thorax 2007)
    97. Inducible and endothelial nitric oxide synthase genes polymorphism in inflammatory bowel disease. (PubMed id 16634870)1, 9 Oliver J....MartA-n J. (Tissue Antigens 2006)
    98. Association between achalasia and nitric oxide synthase gene polymorphisms. (PubMed id 16848803)1, 9 Mearin F....Lanas A. (Am. J. Gastroenterol. 2006)
    99. [Expression of hypoxia-inducible factor-1alpha in nasal polyps and its correlation with vascular endothelial growth factor and inducible nitric oxide synthase]. (PubMed id 16229182)1, 9 Liu Y....Zhang P. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005)
    100. Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium. (PubMed id 15107292)1, 9 Zheng S....Erzurum S.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2004)
    101. Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II. (PubMed id 11880293)1, 9 Pechkovsky D.V....MA1ller-Quernheim J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2002)
    102. Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium. (PubMed id 9239710)1, 9 Telfer J.F....Cameron I.T. (Mol. Hum. Reprod. 1997)
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    104. Histo- and immunocytochemical detection of inducible NOS and TNF-alpha in the locus coeruleus of human opiate addicts. (PubMed id 19038328)1, 9 Dyuizen I. and Lamash N.E. (J. Chem. Neuroanat. 2009)
    105. Constitutive intracellular production of iNOS and NO in human melanoma: possible role in regulation of growth and resistance to apoptosis. (PubMed id 18472017)1, 9 Grimm E.A....Ekmekcioglu S. (Nitric Oxide 2008)
    106. Nasal mucosal expression of nitric oxide synthases in patients with allergic rhinitis and its relation to asthma. (PubMed id 18254476)1, 9 Yuksel H....Ozbilgin K. (amp 2008)
    107. Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2. (PubMed id 18753331)1, 9 Tsutsumi S....Mendelsohn M.E. (J. Endocrinol. 2008)
    108. Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. (PubMed id 17328085)1, 9 Li C....Wei Q. (Cancer 2007)
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    110. Mifepristone-induced nitric oxide release and expression of nitric oxide synthases in the human cervix during early pregnancy. (PubMed id 16684839)1, 9 VAoisAonen-Tommiska M....Mikkola T.S. (Hum. Reprod. 2006)
    111. UVB radiation-mediated expression of inducible nitric oxide synthase activity and the augmenting role of co-induced TNF-alpha in human skin endothelial cells. (PubMed id 15482484)1, 9 Suschek C.V....Kolb-Bachofen V. (J. Invest. Dermatol. 2004)
    112. Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria. (PubMed id 12552317)1, 9 Burgner D....Kwiatkowski D.P. (Hum. Genet. 2003)
    113. Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. (PubMed id 12490535)1, 9 Levecque C....Chartier-Harlin M.C. (Hum. Mol. Genet. 2003)
    114. Nitric oxide synthase expression in human bladder cancer and its relation to angiogenesis. (PubMed id 12937869)1, 9 Lin Z....Zhu S. (Urol. Res. 2003)
    115. Inducible nitric oxide, synthase in renal cell carcinoma: expression in tumor thrombi and induction under hypoxic conditions. (PubMed id 14981908)1, 9 Hara N....Tomita Y. (Anticancer Res. 2003)
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    117. (CCTTT)n repeat polymorphism in the NOS2 gene promoter is associated with atopy. (PubMed id 11692109)1, 9 Konno S....Nishimura M. (J. Allergy Clin. Immunol. 2001)
    118. Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. (PubMed id 20405237)1, 9 Shan Y....Wang S. (Cardiovasc. Toxicol. 2010)
    119. Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils. (PubMed id 20232214)1, 9 Saluja R....Dikshit M. (Cell Tissue Res. 2010)
    120. Nitric oxide synthase in gingival tissues of patients with chronic periodontitis and with and without diabetes. (PubMed id 20059423)1, 9 Pan Z....Bulut S. (J. Periodontol. 2010)
    121. Expression and prognostic significance of iNOS in uveal melanoma. (PubMed id 19847812)1, 9 Johansson C.C....Kiessling R. (Int. J. Cancer 2010)
    122. Delayed and acute effects of interferon-gamma on activity of an inwardly rectifying K+ channel in cultured human proximal tubule cells. (PubMed id 18945831)1, 9 Nakamura K....Kubokawa M. (Am. J. Physiol. Renal Physiol. 2009)
    123. Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity. (PubMed id 19837302)1, 9 Ratajczak-Wrona W....Piotrowski L. (J. Oral Maxillofac. Surg. 2009)
    124. [Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma]. (PubMed id 19799816)1, 9 Wang Y.Y....Li J.S. (Ai Zheng 2009)
    125. Widespread expression of inducible NOS and citrulline in lupus nephritis tissues. (PubMed id 19184355)1, 9 Bollain-y-Goytia J.J....Herrera-Esparza R. (Inflamm. Res. 2009)
    126. Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin. (PubMed id 19130609)1, 9 Fetz V....Knauer S.K. (Int. J. Cancer 2009)
    127. Cross-talk between inducible nitric oxide synthase and cyclooxygenase in Helicobacter-pylori-induced gastritis. (PubMed id 19797925)1, 9 Franco L. and Talamini G. (Med Princ Pract 2009)
    128. Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma. (PubMed id 17657783)1, 9 Brennan P.A....Thomas G.J. (amp 2008)
    129. Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species. (PubMed id 18091741)1, 9 Zhen J....Zhou X.J. (Am. J. Hypertens. 2008)
    130. Nitric oxide overproduction derived from inducible nitric oxide synthase increases cardiomyocyte apoptosis in human atrial fibrillation. (PubMed id 18585800)1, 9 Han W....Huo H. (Int. J. Cardiol. 2008)
    131. (CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study. (PubMed id 18714530)1, 9 Pascual M....Lorente F. (amp 2008)
    132. Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. (PubMed id 17849424)1, 9 Vaninetti N.M....Casson A.G. (Mol. Carcinog. 2008)
    133. Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease. (PubMed id 17675371)1, 9 TadiAc J.M....Delclaux C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008)
    134. Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. (PubMed id 18515325)1, 9 Alba G....Sobrino F. (J. Leukoc. Biol. 2008)
    135. Polymorphisms in angiogenesis-related genes and prostate cancer. (PubMed id 18398039)1, 9 Jacobs E.J....Rodriguez C. (amp 2008)
    136. Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion. (PubMed id 18024942)1, 9 Tsui J.C....Dashwood M.R. (Angiology 2007)
    137. Inducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma risk. (PubMed id 17482959)1, 9 Shen C.H....Chiou H.Y. (Urology 2007)
    138. Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility. (PubMed id 17955236)1, 9 MartA-n M.C....Urcelay E. (Immunogenetics 2007)
    139. Inducible nitric oxide synthase (iNOS) gene polymorphism in pre-eclampsia: a pilot study in North India. (PubMed id 17991113)1, 9 Bhatnagar S....Sarma P.U. (amp 2007)
    140. Dissociation between adipose nitric oxide synthase expression and tissue metabolism. (PubMed id 17456572)1, 9 Engeli S....Jordan J. (J. Clin. Endocrinol. Metab. 2007)
    141. Lack of association between NOS2 pentanucleotide repeat polymorphism and asthma phenotypes or exhaled nitric oxide concentration. (PubMed id 16703578)1, 9 Leung T.F....Wong G.W. (Pediatr. Pulmonol. 2006)
    142. Analysis of the inducible nitric oxide synthase gene polymorphisms in Czech patients with atopic diseases. (PubMed id 17177683)1, 9 Holla L.I....Vasku A. (Clin. Exp. Allergy 2006)
    143. Nitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes. (PubMed id 17070441)1, 9 Liao L....Lee K.O. (J. Diabetes Complicat. 2006)
    144. [Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus]. (PubMed id 15856945)1, 9 Zotova E.V....Nosikov V.V. (Mol. Biol. (Mosk.) 2005)
    145. Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter. (PubMed id 15617837)1, 9 Tatemichi M....Ohshima H. (Cancer Lett. 2005)
    146. Role of inducible nitric oxide synthase expression in aberrant crypt foci-adenoma-carcinoma sequence. (PubMed id 12800233)1, 9 Xu M.H....Lin J. (World J. Gastroenterol. 2003)
    147. A functional variant of the iNOS gene flanking region is associated with LAD coronary artery disease: an autopsy study. (PubMed id 14636285)1, 9 Kunnas T.A....Karhunen P.J. (Eur. J. Clin. Invest. 2003)
    148. Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis. (PubMed id 12598314)1, 9 Cianchi F....Masini E. (Am. J. Pathol. 2003)
    149. Immunocytochemical localization of cytokines and inducible nitric oxide synthase (iNOS) in oral mucosa and lymph nodes of patients with paracoccidioidomycosis. (PubMed id 12824008)1, 9 Neworal E.P....Blotta M.H. (Cytokine 2003)
    150. Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas. (PubMed id 12406306)1, 9 Kumamoto H....Ooya K. (amp 2002)
    151. Genetic determinants of rheumatoid arthritis: the inducible nitric oxide synthase (NOS2) gene promoter polymorphism. (PubMed id 12140750)1, 9 Pascual M....MartA-n J. (Genes Immun. 2002)
    152. Expression of nitric oxide synthase in human central nervous system tumors. (PubMed id 7531613)1, 9 Cobbs C.S....Israel M.A. (Cancer Res. 1995)
    153. The nongenomic effects of progesterone in repressing iNOS activation through P38MAPK pathways in gonococci-infected polymorphonuclear leukocytes and the clinical significance. (PubMed id 20155468)1, 9 Chen R....Chen H. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2010)
    154. Transient hyperoxic reoxygenation reduces cytochrome C oxidase activity by increasing superoxide dismutase and nitric oxide. (PubMed id 20086011)1, 9 Arab A....Hehrlein C. (J. Biol. Chem. 2010)
    155. [Polymorphism of eNOS and iNOS Genes and Chronic Heart Failure in Patients With Ischemic Heart Disease]. (PubMed id 20459417)1, 9 Tepliakov A.T....Karpov R.S. (Kardiologiia 2010)
    156. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. (PubMed id 19797159)1, 9 Brindicci C....Ito K. (Am. J. Respir. Crit. Care Med. 2010)
    157. Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase. (PubMed id 19539448)1, 9 Portugal-Cohen M. and Kohen R. (J. Dermatol. Sci. 2009)
    158. Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase. (PubMed id 19737939)1, 9 Xia C....Kim J.J. (J. Biol. Chem. 2009)
    159. Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase. (PubMed id 19828635)1, 9 Liu X.D....Eissa N.T. (J. Immunol. 2009)
    160. Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. (PubMed id 19291698)1, 9 Li W....Zhu Y. (Eur. J. Immunol. 2009)
    161. Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. (PubMed id 19238344)1, 9 Wang H....MacNaughton W.K. (J. Mol. Med. 2009)
    162. Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. (PubMed id 19912632)1, 9 Hoehn T....Wadsworth R.M. (Respir. Res. 2009)
    163. YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells. (PubMed id 18923065)1, 9 Liu X.M....Durante W. (Mol. Pharmacol. 2009)
    164. CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation. (PubMed id 19362296)1, 9 Chen L....Yin Z. (Cell. Immunol. 2009)
    165. Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes. (PubMed id 18390757)1, 9 Vareille M....Gobert A.P. (J. Immunol. 2008)
    166. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. (PubMed id 18849972)1, 9 Garcin E.D....Getzoff E.D. (Nat. Chem. Biol. 2008)
    167. Production of nitric oxide and expression of inducible nitric oxide synthase in ovarian cystic tumors. (PubMed id 19132106)1, 9 Nomelini R.S....Murta E.F. (Mediators Inflamm. 2008)
    168. Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (PubMed id 18349295)1, 9 Ferguson H.R....Hardie L.J. (amp 2008)
    169. Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression. (PubMed id 18077487)1, 9 Valvason C....Punzi L. (Rheumatology (Oxford) 2008)
    170. Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis. (PubMed id 18580885)1, 9 Barcellos L.F....Oksenberg J.R. (Genes Immun. 2008)
    171. Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis. (PubMed id 19381485)1, 9 FundovA! P....TlaskalovA!-HogenovA! H. (Folia Microbiol. (Praha) 2008)
    172. Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease. (PubMed id 18579559)1, 9 Calvisi D.F....Pascale R.M. (Carcinogenesis 2008)
    173. Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunction. (PubMed id 18571252)1, 9 MAoki-PetAojAo K.M....Wilkinson I.B. (Int. J. Cardiol. 2008)
    174. Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. (PubMed id 18474259)1, 9 Hammadi A....Kolb J.P. (Nitric Oxide 2008)
    175. Preliminary evidences of a NOS2A protective effect from relapsing-remitting multiple sclerosis. (PubMed id 17854833)1, 9 Manna I....Quattrone A. (J. Neurol. Sci. 2008)
    176. Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility. (PubMed id 17709521)1, 9 van de Sande W.W....van Belkum A. (J. Immunol. 2007)
    177. Early upregulation of iNOS mRNA expression and increase in NO metabolites in pressurized renal epithelial cells. (PubMed id 17881462)1, 9 Broadbelt N.V....Felsen D. (Am. J. Physiol. Renal Physiol. 2007)
    178. Genetic polymorphisms in the oxidative stress pathway and susceptibility to non-Hodgkin lymphoma. (PubMed id 17149600)1, 9 Lan Q....Chanock S. (Hum. Genet. 2007)
    179. Arginine and immunity. (PubMed id 17513447)7, 9 Popovic P.J....Ochoa J.B. (J. Nutr. 2007)
    180. IL-4 stimulates the expression of CXCL-8, E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells. (PubMed id 17494951)7, 9 Huang H....Lavoie J.P. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    181. Polymorphisms within inflammatory genes and colorectal cancer. (PubMed id 17062130)1, 9 Landi S....Moreno V. (J Negat Results Biomed 2006)
    182. Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS. (PubMed id 16326029)1, 9 Loibl S....Kaufmann M. (Pathol. Res. Pract. 2006)
    183. Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. (PubMed id 16456243)1, 9 Shehata S.M....Tibboel D. (Cell Biochem. Biophys. 2006)
    184. Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages. (PubMed id 16335796)1, 9 Woo C.W....O K. (Mol. Cell. Biochem. 2005)
    185. Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival. (PubMed id 15849807)1, 9 Li L.G. and Xu H.M. (World J. Gastroenterol. 2005)
    186. An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. (PubMed id 15856071)1, 9 Bugeja M.J....Stewart G.J. (Eur. J. Hum. Genet. 2005)
    187. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. (PubMed id 16260491)1, 9 Nathan C....Beal M.F. (J. Exp. Med. 2005)
    188. A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer. (PubMed id 15484300)1, 9 Shen J....Wang X.R. (World J. Gastroenterol. 2004)
    189. Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy. (PubMed id 15284293)1, 9 Qiu L.Q....Hsu S.I. (J. Am. Soc. Nephrol. 2004)
    190. Relationship between inducible nitric oxide synthase expression and angiogenesis in primary gallbladder carcinoma tissue. (PubMed id 14991947)1, 9 Niu X.J....Qing X.L. (World J. Gastroenterol. 2004)
    191. Inducible but not endothelial nitric oxide synthase polymorphism is associated with susceptibility to rheumatoid arthritis in northwest Spain. (PubMed id 15226517)1, 9 Gonzalez-Gay M.A....Martin J. (Rheumatology (Oxford) 2004)
    192. Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population. (PubMed id 15275951)1, 9 Tajouri L....Griffiths L.R. (Brain Res. Bull. 2004)
    193. Nitric oxide synthase in healthy and inflamed human dental pulp. (PubMed id 15044505)1, 9 Di Nardo Di Maio F....Felaco M. (J. Dent. Res. 2004)
    194. Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. (PubMed id 15174013)1, 9 Barcellos L.F....Oksenberg J.R. (Ann. Neurol. 2004)
    195. Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions. (PubMed id 14574328)1, 9 Tiscornia A.C....Pritsch O. (Leukemia 2004)
    196. Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma. (PubMed id 15259072)1, 9 Chang C.S....Wang C.J. (World J. Gastroenterol. 2004)
    197. JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes. (PubMed id 15115662)1, 9 Zhang B....Harbrecht B.G. (Cell. Signal. 2004)
    198. Nitric oxide synthase gene polymorphisms and diabetic nephropathy. (PubMed id 12687343)1, 9 Rippin J.D....Bain S.C. (Diabetologia 2003)
    199. No association of inducible nitric oxide synthase gene ( NOS2A) to multiple sclerosis. (PubMed id 12736741)1, 9 Blanco Y....Saiz A. (J. Neurol. 2003)
    200. Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. (PubMed id 12875991)1, 9 Gallo O....Capaccioli S. (Am. J. Pathol. 2003)
    201. Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains. (PubMed id 12777376)1, 9 Guan Z.W....Iyanagi T. (J. Biol. Chem. 2003)
    202. Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. (PubMed id 12590140)1, 9 Warke V.G....Tsokos G.C. (J. Biol. Chem. 2003)
    203. Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. (PubMed id 14677189)1, 9 Lamarque D....Claudepierre P. (J. Rheumatol. 2003)
    204. Human renal epithelial cells express iNOS in response to cytokines but not bacteria. (PubMed id 11849384)1, 9 Poljakovic M....Persson K. (Kidney Int. 2002)
    205. Hepatocyte growth factor induced human trophoblast motility involves phosphatidylinositol-3-kinase, mitogen-activated protein kinase, and inducible nitric oxide synthase. (PubMed id 12243747)1, 9 Cartwright J.E....Whitley G.S. (Exp. Cell Res. 2002)
    206. Immunohistochemical expression of cytokine induced nitric oxide synthase in colorectal carcinoma. (PubMed id 11956620)1, 9 Nozoe T....Korenaga D. (Oncol. Rep. 2002)
    207. Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis. (PubMed id 12445411)1, 9 Sanz-Cameno P....Moreno-Otero R. (J. Hepatol. 2002)
    208. Significant association of longer forms of CCTTT Microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand. (PubMed id 12195390)1, 9 Ohashi J....Tokunaga K. (J. Infect. Dis. 2002)
    209. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. (PubMed id 12374680)1, 9 Ikeguchi M....Kaibara N. (Clin. Cancer Res. 2002)
    210. Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity. (PubMed id 12097137)1, 9 Lanone S....Mebazaa A. (Biochem. J. 2002)
    211. Inducible nitric oxide synthase is expressed in synovial fluid granulocytes. (PubMed id 12296866)1, 9 Cedergren J....Skogh T. (Clin. Exp. Immunol. 2002)
    212. Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies. (PubMed id 11297817)1, 9 Singleton A.B....Morris C.M. (Neurosci. Lett. 2001)
    213. Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. (PubMed id 9873034)7, 9 Sennequier N....Stuehr D.J. (J. Biol. Chem. 1999)
    214. Nitric oxide inhibits HIV tat-induced NF-kappaB activation. (PubMed id 10393859)1, 9 Chen F....Demers L.M. (Am. J. Pathol. 1999)
    215. Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome. (PubMed id 10068656)1, 9 Hori K....Clouse K.A. (Blood 1999)
    216. Inducible nitric oxide synthase in the liver: regulation and function. (PubMed id 9721329)2, 9 Taylor B.S.... Billiar T.R. (Biokhimiia 1998)
    217. Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. (PubMed id 9284131)1, 9 Nozaki Y....Shimokata K. (Infect. Immun. 1997)
    218. Constitutive expression and structural diversity of inducible isoform of nitric oxide synthase in human tissues. (PubMed id 8699932)1, 9 Park C.S....Krishna G. (Life Sci. 1996)
    219. Inducible nitric oxide synthase in a human glioblastoma cell line. (PubMed id 7528267)2, 9 Fujisawa H.... Esumi H. (J. Neurochem. 1995)
    220. Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. (PubMed id 7561697)1, 9 Koka P....Merrill J.E. (J. Exp. Med. 1995)
    221. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. (PubMed id 7524082)1, 9 Asano K....Stamler J.S. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    222. Nitric oxide synthase gene polymorphisms in functional dyspepsia. (PubMed id 24114042)1 Park J.M....Choi M.G. (Dig. Dis. Sci. 2014)
    223. Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils. (PubMed id 22734893)1 Ratajczak-Wrona W....Iwaniuk A. (J Immunotoxicol 2013)
    224. Association analysis of nitric oxide synthases: NOS1, NOS2A and NOS3 genes, with multiple sclerosis. (PubMed id 23826716)1 AlFadhli S....Al Shubaili A. (Ann. Hum. Biol. 2013)
    225. Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. (PubMed id 23261943)1 Bhowmick R. and Girotti A.W. (amp 2013)
    226. Expressions of candidate molecules in the human fallopian tube and chorionic villi of tubal pregnancy exposed to levonorgestrel emergency contraception. (PubMed id 23687977)1 Huang C....Zhang J. (amp 2013)
    227. A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations. (PubMed id 23192595)1 Wang Z....Zhou G. (Hum. Genet. 2013)
    228. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    229. Protein nitration promotes inducible nitric oxide synthase transcription mediated by NF-I_B in high glucose-stimulated human lens epithelial cells. (PubMed id 23454417)1 Li Y....Qi J. (Mol. Cell. Endocrinol. 2013)
    230. Regulatory role of Glu546 in flavin mononucleotide-heme electron transfer in human inducible nitric oxide synthase. (PubMed id 23570607)1 Li W....Feng C. (Inorg Chem 2013)
    231. NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism. (PubMed id 23338972)1 Zhu H....Amin H.M. (J. Pathol. 2013)
    232. ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: up- and down-regulation of PGE2 + IFNI^-induced IL-6 and iNOS expressions. (PubMed id 24177007)1 Hosoi T....Ozawa K. (Biochem. Biophys. Res. Commun. 2013)
    233. Genetic and clinical contributions to cerebral palsy: a multi-variable analysis. (PubMed id 23773706)1 O'Callaghan M.E....Dekker G.A. (J Paediatr Child Health 2013)
    234. KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection. (PubMed id 23831683)1 Mgbemena V....Bose S. (Cell. Immunol. 2013)
    235. Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport. (PubMed id 23471078)1 Bollmann F....Pautz A. (Nitric Oxide 2013)
    236. Clinicopathological implications of the expression of hypoxia-related proteins in gastric cancer. (PubMed id 23935399)1 Jung J.H....Kang C.S. (Int J Med Sci 2013)
    237. Zinc ferrite nanoparticles activate IL-1b, NFKB1, CCL21 and NOS2 signaling to induce mitochondrial dependent intrinsic apoptotic pathway in WISH cells. (PubMed id 24035972)1 Saquib Q....Musarrat J. (Toxicol. Appl. Pharmacol. 2013)
    238. Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation. (PubMed id 23599434)1 Lee M. and Choy J.C. (J. Biol. Chem. 2013)
    239. In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes. (PubMed id 23764028)1 Price I....Vodovotz Y. (J. Theor. Biol. 2013)
    240. Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP). (PubMed id 23711718)1 Casper I....Pautz A. (Nitric Oxide 2013)
    241. Cell stress molecules in the skeletal muscle of GNE myopathy. (PubMed id 23496965)1 Fischer C....Schmidt J. (BMC Neurol 2013)
    242. Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells. (PubMed id 23233037)1 Nunes C....Laranjinha J. (amp 2013)
    243. Loss of methylation in CpG sites in the NF-I_B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes. (PubMed id 23239081)1 de AndrAcs M.C....Oreffo R.O. (Arthritis Rheum. 2013)
    244. TNF-I+ and IFN-I^ are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis. (PubMed id 22992806)1 Viard-Leveugle I....French L.E. (J. Invest. Dermatol. 2013)
    245. Inducible nitric oxide synthase (iNOS) in sinonasal polyp pathogenesis. (PubMed id 24273952)1 Muluk N.B....YalAsinozan E.T. (B-ENT 2013)
    246. Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis. (PubMed id 23452051)1 Petrtyl J....Bruha R. (Scand. J. Gastroenterol. 2013)
    247. Ciliated cultures from patients with primary ciliary dyskinesia do not produce nitric oxide or inducible nitric oxide synthase during early infection. (PubMed id 24189859)1 Smith C.M....O'Callaghan C. (Chest 2013)
    248. Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling. (PubMed id 23797095)1 Obermajer N....Kalinski P. (J. Exp. Med. 2013)
    249. Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy. (PubMed id 23266817)1 Oliveira-Paula G.H....Tanus-Santos J.E. (Gene 2013)
    250. Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans. (PubMed id 23572278)1 Montesanto A....Rose G. (Biogerontology 2013)
    251. Regulation of iNOS expression by NF-I_B in human lens epithelial cells treated with high levels of glucose. (PubMed id 23812491)1 Jia J....Qi J. (amp 2013)
    252. miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes. (PubMed id 22451906)1 Guo Z....Geller D.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    253. Single nucleotide polymorphisms in the NOS2 and NOS3 genes are associated with exhaled nitric oxide. (PubMed id 22368302)1 Dahgam S....Olin A.C. (J. Med. Genet. 2012)
    254. Why does the fallopian tube fail in ectopic pregnancy? The role of activins, inducible nitric oxide synthase, and MUC1 in ectopic implantation. (PubMed id 22425195)1 Refaat B....Ledger W. (Fertil. Steril. 2012)
    255. Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. (PubMed id 22409880)1 Seymour M....Taylor P.C. (Clin. Exp. Rheumatol. 2012)
    256. Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy. (PubMed id 21716319)1 Amaral L.M....Tanus-Santos J.E. (J Hum Hypertens 2012)
    257. Structure and dynamics of calmodulin (CaM) bound to nitric oxide synthase peptides: effects of a phosphomimetic CaM mutation. (PubMed id 22486744)1 Piazza M....Guillemette J.G. (Biochemistry 2012)
    258. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    259. Association of NOS2 and potential effect of VEGF, IL6, CCL2 and IL1RN polymorphisms and haplotypes on susceptibility to GCA--a simultaneous study of 130 potentially functional SNPs in 14 candidate genes. (PubMed id 22258388)1 Enjuanes A....Cid M.C. (Rheumatology (Oxford) 2012)
    260. Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. (PubMed id 22711891)1 Mgbemena V....Bose S. (J. Immunol. 2012)
    261. Formation of ternary complex of human biliverdin reductase-protein kinase CI'-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-I_B, and inducible nitric-oxidase synthase (iNOS). (PubMed id 22065579)1 Gibbs P.E....Maines M.D. (J. Biol. Chem. 2012)
    262. Expression of nitric oxide synthases in leukocytes in nasal polyps. (PubMed id 22374200)1 Yoshimura T....Befus A.D. (amp 2012)
    263. The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. (PubMed id 22331023)1 GaA8ecki P....Szemraj J. (J Affect Disord 2012)
    264. Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children. (PubMed id 22055874)1 Salam M.T....Gilliland F.D. (J. Allergy Clin. Immunol. 2012)
    265. Effects of Feiyanning Decoction, a compound traditional Chinese medicine, on iNOS and COX-2 expressions induced by tumor necrosis factor-I+ in lung adenocarcinoma cell line. (PubMed id 22704420)1 Wang J.Y....Wang Q. (Zhong Xi Yi Jie He Xue Bao 2012)
    266. Production of nitric oxide is lower in Shiga toxin-stimulated neutrophils of infants compared to those of children or adults. (PubMed id 23089636)1 Tsuji S....Kaneko K. (Tohoku J. Exp. Med. 2012)
    267. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. (PubMed id 22438824)1 Haag D....Lichter P. (PLoS Genet. 2012)
    268. Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk. (PubMed id 23002365)1 Rafiei A....Merrell D.S. (World J. Gastroenterol. 2012)
    269. Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS. (PubMed id 22349263)1 Reveneau S....Pance A. (Cell. Mol. Life Sci. 2012)
    270. Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: comparison with glutathione modifiers. (PubMed id 21710354)1 Ahmadi-Ashtiani H....Barkhordari E. (J Nat Med 2012)
    271. Expression levels of cyclooxygenase-2, tumor necrosis factor-I+ and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies. (PubMed id 22014124)1 Goksu Erol A.Y....Yildiz S.E. (amp 2012)
    272. Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteins. (PubMed id 22198200)1 Li W....Feng C. (FEBS Lett. 2012)
    273. [Construction of A eukaryotic expression vector carrying the iNOS gene and its effect on A549 lung cancer cells]. (PubMed id 22613330)1 Ye S....Zhu W. (Zhongguo Fei Ai Za Zhi 2012)
    274. Anti-inflammatory potential of an ethyl acetate fraction isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-I_B pathway. (PubMed id 22063737)1 Kumar K.S....Helen A. (Cell. Immunol. 2012)
    275. Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. (PubMed id 22957045)1 Ridnour L.A....Wink D.A. (PLoS ONE 2012)
    276. The role of inducible nitric oxide synthase and haem oxygenase 1 in growth and development of dental tissue'. (PubMed id 22147556)1 Speranza L....Grilli A. (Cell Biochem. Funct. 2012)
    277. [The expression and correlation of inducible nitric oxide synthase, Bax and Bcl-2 in nasal polyps]. (PubMed id 22675938)1 Liu Y....Wu W. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2012)
    278. Interaction among nitric oxide (NO)-related genes in migraine susceptibility. (PubMed id 22865486)1 GonAsalves F.M....Tanus-Santos J.E. (Mol. Cell. Biochem. 2012)
    279. Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small cell lung cancer patients following the definitive radiochemotherapy. (PubMed id 22862164)1 Zhang J....Huang W. (Neoplasma 2012)
    280. Helicobacter pylori regulates iNOS promoter by histone modifications in human gastric epithelial cells. (PubMed id 22215089)1 Angrisano T....Pero R. (Med. Microbiol. Immunol. 2012)
    281. Hypoxia induces nitric oxide synthase in rheumatoid synoviocytes: consequences on NADPH oxidase regulation. (PubMed id 22329647)1 Chenevier-Gobeaux C....Borderie D. (Free Radic. Res. 2012)
    282. Obesity, insulin resistance, and skeletal muscle nitric oxide synthase. (PubMed id 22797309)1 Kraus R.M....Hickner R.C. (J. Appl. Physiol. 2012)
    283. Acute pancreatitis is associated with Ser608Leu iNOS polymorphism. (PubMed id 23438852)1 A9zhan G....Alpertunga B. (Folia Biol. (Praha) 2012)
    284. Inducible nitric oxide synthase haplotype associated with migraine and aura. (PubMed id 22234503)1 de O S Mansur T....Tanus-Santos J.E. (Mol. Cell. Biochem. 2012)
    285. Nitric oxide synthase and tyrosine nitration in idiopathic asthenozoospermia: an immunohistochemical study. (PubMed id 22244784)1 Salvolini E....Balercia G. (Fertil. Steril. 2012)
    286. High glucose decreases expression and activity of p-glycoprotein in cultured human retinal pigment epithelium possibly through iNOS induction. (PubMed id 22363694)1 Zhang Y....Ruan X. (PLoS ONE 2012)
    287. The apoptosis pathway and the genetic predisposition to Achilles tendinopathy. (PubMed id 22588838)1 Nell E.M....September A.V. (J. Orthop. Res. 2012)
    288. Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation. (PubMed id 22209000)1 Leidi M....Maier J.A. (J. Nutr. Biochem. 2012)
    289. Arginine-nitric oxide-polyamine metabolism in periodontal disease. (PubMed id 20831369)1 Ozer L....Ozmeric N. (J. Periodontol. 2011)
    290. Association of the pentanucleotide repeat polymorphism in NOS2 promoter region with susceptibility to migraine in a Chinese population. (PubMed id 20874490)1 Jia S....Gao Y. (DNA Cell Biol. 2011)
    291. Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder. (PubMed id 20888049)1 GaA8ecki P....Szemraj J. (J Affect Disord 2011)
    292. Molecular and biochemical characterization of nitric oxide synthase isoforms and their intracellular distribution in human peripheral blood mononuclear cells. (PubMed id 21722677)1 Saluja R....Dikshit M. (Biochim. Biophys. Acta 2011)
    293. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. (PubMed id 21690090)1 Shin H.J....Yu D.Y. (J. Biol. Chem. 2011)
    294. Inducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patients. (PubMed id 21333324)1 Zhang W....Tao H.Q. (Hum. Pathol. 2011)
    295. Effect of solution viscosity on intraprotein electron transfer between the FMN and heme domains in inducible nitric oxide synthase. (PubMed id 21803041)1 Li W....Feng C. (FEBS Lett. 2011)
    296. [Expression of iNOS protein and gliacyte apoptosis in neonatal rats with white matter damage]. (PubMed id 21507301)1 Wang H.Q....Guo W.J. (Zhongguo Dang Dai Er Ke Za Zhi 2011)
    297. Analysis of inducible nitric oxide synthase gene polymorphisms in vitiligo in Han Chinese people. (PubMed id 22205923)1 Zhang Y....Gao T. (PLoS ONE 2011)
    298. Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability. (PubMed id 21535025)1 Forsyth C.B....Keshavarzian A. (Alcohol. Clin. Exp. Res. 2011)
    299. Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase. (PubMed id 21547253)1 Turpeinen T....Korhonen R. (Mediators Inflamm. 2011)
    300. Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells. (PubMed id 20713430)1 Lyn-Cook L.E....Hammons G.J. (Toxicol Ind Health 2011)
    301. Ser608Leu polymorphisms in the nitric oxide synthase-2 gene may influence urinary bladder cancer pathogenesis. (PubMed id 21612325)1 Ryk C....De Verdier P.J. (Scand. J. Urol. Nephrol. 2011)
    302. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    303. S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase. (PubMed id 21533769)1 Dunn J....Santhanam L. (Mol. Cell. Biochem. 2011)
    304. Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. (PubMed id 21729780)1 Eyler C.E....Rich J.N. (Cell 2011)
    305. Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS. (PubMed id 21744319)1 Mauro A....Gerbino A. (Folia Histochem. Cytobiol. 2011)
    306. Role of nitric oxide (NO) metabolism and inflammatory mediators in childhood obesity. (PubMed id 21874355)1 HrabA!k A....KAPrner A. (Inflamm. Res. 2011)
    307. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. (PubMed id 21700708)1 Tanioka T....Kaneki M. (J. Biol. Chem. 2011)
    308. NOS2A as a candidate gene in Relapsing-Remitting Multiple Sclerosis: a haplotype study using selected subsets of single nucleotide polymorphisms. (PubMed id 21376344)1 Manna I....Gambardella A. (J. Neurol. Sci. 2011)
    309. Curcumin promotes degradation of inducible nitric oxide synthase and suppresses its enzyme activity in RAW 264.7 cells. (PubMed id 21094287)1 Ben P....Yin Z. (Int. Immunopharmacol. 2011)
    310. The tissue microlocalisation and cellular expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 is correlated to clinical outcome in NSCLC. (PubMed id 21799753)1 Ohri C.M....Bradding P. (PLoS ONE 2011)
    311. Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in MAcniA"re's disease in a European Caucasian population. (PubMed id 21612410)1 Gazquez I....Lopez-Nevot M.A. (DNA Cell Biol. 2011)
    312. [Effects of hypoxia inducible factor-1 I+ siRNA on inducible nitric oxide synthase expression in HaCaT cells]. (PubMed id 22086003)1 Li Y....Wen H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011)
    313. NF-kappaB-mediated modulation of inducible nitric oxide synthase activity controls induction of the Epstein-Barr virus productive cycle by transforming growth factor beta 1. (PubMed id 21507981)1 Oussaief L....Joab I. (J. Virol. 2011)
    314. Expression of nitric oxide synthases in primary ciliary dyskinesia. (PubMed id 21663943)1 Degano B....Arnal J.F. (Hum. Pathol. 2011)
    315. The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. (PubMed id 21549100)1 Matsumoto K....Miwa S. (Biochem. Biophys. Res. Commun. 2011)
    316. Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase. (PubMed id 21481004)1 Karasneh J.A....Thornhill M. (amp 2011)
    317. Growth hormone releasing hormone induces the expression of nitric oxide synthase. (PubMed id 20518847)1 Barabutis N....Schally A.V. (J. Cell. Mol. Med. 2011)
    318. A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase. (PubMed id 20015194)1 Brovkovych V....Skidgel R.A. (J. Cell. Mol. Med. 2011)
    319. I9Np63I+/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure. (PubMed id 21129360)1 Ratovitski E.A. (Arch. Biochem. Biophys. 2011)
    320. PDE-5 and NOS II mRNA expression in menopausal women: a molecular biology study. (PubMed id 20177899)1 Pace G....Vicentini C. (World J Urol 2011)
    321. A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. (PubMed id 21630437)1 Schosser A....McGuffin P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    322. iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach. (PubMed id 20619687)1 Perrotta I....Cassese M. (Cardiovasc. Pathol. 2011)
    323. Expression of TLR 2, TLR 4 and iNOS in cervical monocytes of Chlamydia trachomatis-infected women and their role in host immune response. (PubMed id 21883620)1 Agrawal T....Mittal A. (Am. J. Reprod. Immunol. 2011)
    324. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)1 Nishiya T....Miwa S. (J. Biol. Chem. 2011)
    325. Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis. (PubMed id 21660141)1 Franko A....DolA3an V. (amp 2011)
    326. Mutation in the flavin mononucleotide domain modulates magnetic circular dichroism spectra of the iNOS ferric cyano complex in a substrate-specific manner. (PubMed id 21718007)1 Sempombe J....Feng C. (Inorg Chem 2011)
    327. Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children. (PubMed id 21039601)1 Salam M.T....Gilliland F.D. (Allergy 2011)
    328. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. (PubMed id 21052031)1 Grilo A....SA!ez M.E. (Pharmacogenet. Genomics 2011)
    329. mRNA expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and neuronal nitric oxide synthase genes in meningitis patients. (PubMed id 21204701)1 Oztuzcu S....Cakmak E.A. (Genet Test Mol Biomarkers 2011)
    330. Candidate genes and risk for CP: a population-based study. (PubMed id 21857382)1 Wu Y.W....Torres A.R. (Pediatr. Res. 2011)
    331. Cytotoxic and immune-sensitizing properties of nitric oxide-modified Saquinavir in iNOS-positive human melanoma cells. (PubMed id 21506111)1 Mijatovic S....Nicoletti F. (J. Cell. Physiol. 2011)
    332. Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degeneration. (PubMed id 20374233)1 Ayala-Haedo J.A....Scott W.K. (Ann. Hum. Genet. 2010)
    333. The (CCTTT)n microsatellite polymorphism in the nitric oxide synthase 2 gene may influence bladder cancer pathogenesis. (PubMed id 20850837)1 Ryk C....de Verdier P.J. (J. Urol. 2010)
    334. Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1 Wang Y....Chan J.C. (Diabet. Med. 2010)
    335. Differential roles of nitric oxide synthases in regulation of ultraviolet B light-induced apoptosis. (PubMed id 20547234)1 Liu W. and Wu S. (Nitric Oxide 2010)
    336. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    337. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. (PubMed id 20600019)1 Chaturvedi R....Wilson K.T. (Gastroenterology 2010)
    338. Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism. (PubMed id 20603037)1 Beckers M.M....Biesma D.H. (Eur. J. Intern. Med. 2010)
    339. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (Hum. Immunol. 2010)
    340. Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD. (PubMed id 20581851)1 Tu Y.C....Wang D.W. (Acta Pharmacol. Sin. 2010)
    341. Gastric cancer is associated with NOS2 -954G/C polymorphism and environmental factors in a Brazilian population. (PubMed id 20565800)1 Jorge Y.C....Silva A.E. (BMC Gastroenterol 2010)
    342. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
    343. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1 Ban H.J....Park K.J. (BMC Genet. 2010)
    344. Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. (PubMed id 21054877)1 Ned R.M....Dowling N.F. (BMC Med. Genet. 2010)
    345. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PubMed id 20459687)1 Eid N.A....Ibrahim M.E. (Malar. J. 2010)
    346. [Expression of iNOS and HIF-1I+ with angiogenesis in affected skin biopsies from patients with psoriasis]. (PubMed id 20871160)1 Li Y....Wen H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010)
    347. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. (PubMed id 20978357)1 Glynn S.A....Ambs S. (J. Clin. Invest. 2010)
    348. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (amp 2010)
    349. Genetic influence on baroreflex sensitivity in normotensive young men. (PubMed id 20300066)1 Xing-Sheng Y....Shu-Zheng L. (Am. J. Hypertens. 2010)
    350. Nitric oxide generation in children with malaria and the NOS2G-954C promoter polymorphism. (PubMed id 20811009)1 Planche T....Kremsner P.G. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010)
    351. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    352. Regulation of the expression of inducible nitric oxide synthase. (PubMed id 20438856)1 Pautz A....Kleinert H. (Nitric Oxide 2010)
    353. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    354. Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment. (PubMed id 20541418)1 Tseng I.J....Hu C.J. (J Clin Neurosci 2010)
    355. Reduced iNOS expression in adenoids from children with otitis media with effusion. (PubMed id 21073541)1 Granath A....Cardell L.O. (Pediatr Allergy Immunol 2010)
    356. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    357. Immunohistochemical evaluation of three nitric oxide synthase isoforms in human saphenous vein exposed to different degrees of distension pressures. (PubMed id 20060328)1 Viaro F....Evora P.R. (Cardiovasc. Pathol. 2010)
    358. Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction. (PubMed id 20542496)1 Speckmann B....Steinbrenner H. (amp 2010)
    359. Inducible nitric oxide synthase (iNOS) gene polymorphism and disease prevalence. (PubMed id 21039732)1 Qidwai T. and Jamal F. (Scand. J. Immunol. 2010)
    360. Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia. (PubMed id 20027603)1 Svec J....PA!cha J. (Inflamm. Bowel Dis. 2010)
    361. Correlation between inducible nitric oxide synthase and cyclooxygenase-2 expression in human colorectal adenocarcinoma: a cross-sectional study. (PubMed id 20069397)1 Habibollahi P....Ostad S.N. (Pathol. Oncol. Res. 2010)
    362. Two polypyrimidine tracts in the nitric oxide synthase 2 gene: similar regulatory sequences with different properties. (PubMed id 19669598)1 Motallebipour M....Wadelius C. (Mol. Biol. Rep. 2010)
    363. The expression of inducible nitric oxide synthase in the human fallopian tube during the menstrual cycle and in ectopic pregnancy. (PubMed id 19482272)1 Al-Azemi M....Ledger W. (Fertil. Steril. 2010)
    364. Clinical significance of a myeloperoxidase gene polymorphism and inducible nitric oxide synthase expression in cirrhotic patients with hepatopulmonary syndrome. (PubMed id 20714866)1 Wang Y....Yang D. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2010)
    365. Involvement of Ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells. (PubMed id 19495976)1 Cho S.O....Kim H. (Dig. Dis. Sci. 2010)
    366. Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists. (PubMed id 20711808)1 Schonfeld S.J....Sigurdson A.J. (amp 2010)
    367. Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13). (PubMed id 20634424)1 Mazumdar T....Eissa N.T. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    368. Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort. (PubMed id 21067489)1 Uthra S....Kumaramanickavel G. (Ophthalmic Genet. 2010)
    369. Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator. (PubMed id 20022949)1 Bui-Nguyen T.M....Kumar R. (J. Biol. Chem. 2010)
    370. An inducible nitric oxide synthase polymorphism is associated with the risk of recurrent depressive disorder. (PubMed id 20869428)1 GaA8ecki P....Szemraj J. (Neurosci. Lett. 2010)
    371. Inducible nitric oxide synthase in duodenum of children with Giardia lamblia infection. (PubMed id 20675273)1 Mokrzycka M....Wiszniewska B. (Folia Histochem. Cytobiol. 2010)
    372. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)- Pex5p affinities. (PubMed id 20178365)1 Ghosh D. and Berg J.M. (J. Am. Chem. Soc. 2010)
    373. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    374. Expression of inducible nitric oxide synthase (iNOS) in oral precancer and oral squamous cell carcinoma: an immunohistochemical study. (PubMed id 22012771)1 Varghese S.S....Madhavan R.N. (Cancer Biomark 2010-2011)
    375. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1 Segat L....Crovella S. (Vaccine 2010)
    376. [The role of polymorphic variants of gene of inducible NO-synthase NOS2 in brain infarction in patients with acute ischemic stroke]. (PubMed id 20886685)1 Tupitsyna T.V....SlominskiA- P.A. (Mol. Gen. Mikrobiol. Virusol. 2010)
    377. Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia. (PubMed id 20562898)1 Yoo K.H....Chang S.G. (Asian J. Androl. 2010)
    378. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A. (PubMed id 20100830)1 Ohama T. and Brautigan D.L. (J. Biol. Chem. 2010)
    379. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1 Saus E....Estivill X. (J Psychiatr Res 2010)
    380. Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells. (PubMed id 20600009)1 Siamwala J.H....Chatterjee S. (FEBS Lett. 2010)
    381. The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. (PubMed id 20603330)1 Kuang Z....Nicholson S.E. (J. Cell Biol. 2010)
    382. Electron transfer in a human inducible nitric oxide synthase oxygenase/FMN construct co-expressed with the N-terminal globular domain of calmodulin. (PubMed id 20868689)1 Feng C....Tollin G. (FEBS Lett. 2010)
    383. Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation. (PubMed id 20959455)1 Huang Y. and Ratovitski E.A. (J. Biol. Chem. 2010)
    384. Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase. (PubMed id 20228252)1 Kuhr F.K....Skidgel R.A. (FASEB J. 2010)
    385. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    386. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    387. Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's disease. (PubMed id 20074466)1 Guida G....Bucca C. (Int J Immunopathol Pharmacol 2009)
    388. Triflusal: an old drug in modern antiplatelet therapy. Review of its action, use, safety and effectiveness. (PubMed id 19465361)7 Anninos H....Vardas P. (Hellenic J Cardiol 2009)
    389. Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. (PubMed id 19131335)1 Song W....Matalon S. (J. Biol. Chem. 2009)
    390. Inducible nitric oxide synthase in pityriasis lichenoides lesions. (PubMed id 19220629)1 Di Giunta G....Sotto M.N. (J. Cutan. Pathol. 2009)
    391. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. (PubMed id 19443702)1 Hamada T....Coito A.J. (Am. J. Pathol. 2009)
    392. Hypoxia regulates iNOS expression in human normal peritoneal and adhesion fibroblasts through nuclear factor kappa B activation mechanism. (PubMed id 18281043)1 Jiang Z.L....Saed G.M. (Fertil. Steril. 2009)
    393. Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM. (PubMed id 19358819)1 Chen P.F. and Wu K.K. (Arch. Biochem. Biophys. 2009)
    394. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. (PubMed id 19575238)1 Velez D.R....Scott W.K. (Hum. Genet. 2009)
    395. Effect of UVA irradiation on proliferation and NO/iNOS system of human skin fibroblast. (PubMed id 19734575)1 Chen M....Chen X. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2009)
    396. Nitrosative stress and inducible nitric oxide synthase expression in periventricular leukomalacia. (PubMed id 19415311)1 Haynes R.L....Kinney H.C. (Acta Neuropathol. 2009)
    397. NF-kappaB mediates mitogen-activated protein kinase pathway-dependent iNOS expression in human melanoma. (PubMed id 18668140)1 Uffort D.G....Ellerhorst J.A. (J. Invest. Dermatol. 2009)
    398. Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells. (PubMed id 19306295)1 Wang Y.C....Sun X.Q. (J. Cell. Biochem. 2009)
    399. Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells. (PubMed id 19135542)1 Chambellan A....Erzurum S.C. (Nitric Oxide 2009)
    400. [Time-order expression of caspase-3 and iNOS in contused human brain tissue]. (PubMed id 19788069)1 Cai H.X....Yin W.J. (Fa Yi Xue Za Zhi 2009)
    401. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. (PubMed id 19028820)1 Greisenegger S....Mannhalter C. (Clin. Chem. 2009)
    402. A critical role for CHIP in the aggresome pathway. (PubMed id 18955503)1 Sha Y....Eissa N.T. (Mol. Cell. Biol. 2009)
    403. Inducible and endothelial nitric oxide synthase expression in human atherogenesis: an immunohistochemical and ultrastructural study. (PubMed id 18835789)1 Perrotta I....Cassese M. (Cardiovasc. Pathol. 2009)
    404. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    405. Biochemistry of soluble guanylate cyclase. (PubMed id 19089323)1 Derbyshire E.R. and Marletta M.A. (Handb Exp Pharmacol 2009)
    406. [Significance of lipopolysaccharides, toll-like receptor and inducible nitric oxide synthase in hepatopulmonary syndrome]. (PubMed id 19953876)1 Yi H.M....Chen G.H. (Zhonghua Yi Xue Za Zhi 2009)
    407. A far-upstream Oct-1 motif regulates cytokine-induced transcription of the human inducible nitric oxide synthase gene. (PubMed id 19467240)1 Park K.S....Geller D.A. (J. Mol. Biol. 2009)
    408. Chagasic antibodies induce cardiac COX-2/iNOS mRNA expression with PGE2/NO production. (PubMed id 18579232)1 Ganzinelli S....Sterin-Borda L. (Int. J. Cardiol. 2009)
    409. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    410. LDL and UV-oxidized LDL induce upregulation of iNOS and NO in unstimulated J774 macrophages and HUVEC. (PubMed id 19161531)1 Persson K....Yuan X.M. (APMIS 2009)
    411. Pressure activates epidermal growth factor receptor leading to the induction of iNOS via NFkappaB and STAT3 in human proximal tubule cells. (PubMed id 19403642)1 Broadbelt N.V....Felsen D. (Am. J. Physiol. Renal Physiol. 2009)
    412. Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios. (PubMed id 18563708)1 Kim H.W....Yoo H.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    413. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)1 Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
    414. Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation. (PubMed id 19713467)1 Miki K....Delude R.L. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    415. The role of myeloperoxidase in the pathogenesis of postoperative adhesions. (PubMed id 19614918)1 Saed G.M....Abu-Soud H.M. (Wound Repair Regen 2009)
    416. Role of activins and inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection. (PubMed id 19692623)1 Refaat B....Ledger W. (Clin. Vaccine Immunol. 2009)
    417. Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination. (PubMed id 19376148)1 Chow J.M....Chen Y.C. (Toxicol. Appl. Pharmacol. 2009)
    418. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)
    419. Is apoptosis the cause of noninsertional achilles tendinopathy? (PubMed id 19741110)1 Pearce C.J....Calder J.D. (Am J Sports Med 2009)
    420. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. (PubMed id 18936436)1 Chang M.H....Khoury M.J. (Am. J. Epidemiol. 2009)
    421. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. (PubMed id 19074427)1 Pautz A....Kleinert H. (J. Biol. Chem. 2009)
    422. [Relationship between expression of inducible nitric oxide synthase in nasal mucosa and outcome after endoscopic sinus surgery]. (PubMed id 18476605)1 Lin L....Zheng Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008)
    423. Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions. (PubMed id 18287876)1 Canzian F....Kato I. (Eur. J. Cancer Prev. 2008)
    424. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    425. Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis. (PubMed id 18079278)1 Kiang J.G....Li Y. (Mol. Pharmacol. 2008)
    426. Genetic profiling of genes from the oxidative stress pathway among North and South Indians. (PubMed id 18720901)1 Tiwari A.K....Thelma B.K. (Hum. Biol. 2008)
    427. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. (PubMed id 19096157)1 Colton C.A....Vitek M.P. (J. Alzheimers Dis. 2008)
    428. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. (PubMed id 18676870)1 Hsing A.W....Chanock S.J. (Cancer Res. 2008)
    429. Mitochondrial localization of nitric oxide synthase in partially differentiated urothelial cells of urinary bladder lesions. (PubMed id 18301246)1 Romih R....Jezernik K. (amp 2008)
    430. Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma. (PubMed id 18184270)1 Segawa Y....Tsuneyoshi M. (Histopathology 2008)
    431. Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis. (PubMed id 17553719)1 Atik E....Doran F. (Int. J. Infect. Dis. 2008)
    432. Identification of critical amino acid residues for human iNOS functional activity. (PubMed id 18459037)1 Naureckiene S....Chanda P.K. (Protein J. 2008)
    433. Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction. (PubMed id 18828052)1 Giannubilo S.R....Tranquilli A.L. (amp 2008)
    434. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    435. High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. (PubMed id 18279675)1 Takamiya R....Perrella M.A. (FEBS Lett. 2008)
    436. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    437. Matrix metalloproteinase-2 matrix metalloproteinase-9 and inducible nitric oxide synthase in oral leukoplakia: immunohistochemistry and RT-PCR analysis. (PubMed id 18597705)1 Tortorici S....Tete S. (J. Biol. Regul. Homeost. Agents 2008)
    438. Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes. (PubMed id 18465682)1 Fritzsche K....Punkt K. (amp 2008)
    439. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)1 Ikeda S....Tsugane S. (Am. J. Gastroenterol. 2008)
    440. Global gene expression patterns and induction of innate immune response in human laryngeal epithelial cells in response to Acinetobacter baumannii outer membrane protein A. (PubMed id 18625015)1 Kim S.A....Lee J.C. (FEMS Immunol. Med. Microbiol. 2008)
    441. Long-term survival after ischemic stroke in postmenopausal women is affected by an interaction between smoking and genetic variation in nitric oxide synthases. (PubMed id 18648197)1 Oksala N.K....Karhunen P.J. (Cerebrovasc. Dis. 2008)
    442. Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide. (PubMed id 18675932)1 Rosa S.C....Mendes A.F. (Nitric Oxide 2008)
    443. Expression of endothelial and inducible nitric oxide synthase and caspase-3 in tonsillar cancer, chronic tonsillitis and healthy tonsils. (PubMed id 19178812)1 Lukes P....Astl J. (Folia Biol. (Praha) 2008)
    444. Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells. (PubMed id 18820242)1 Korneev S.A....O'Shea M. (RNA 2008)
    445. CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells. (PubMed id 19059114)1 Choy J.C....Pober J.S. (J. Heart Lung Transplant. 2008)
    446. iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. (PubMed id 18217711)1 Li F. and Mahato R.I. (Mol. Pharm. 2008)
    447. Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasia. (PubMed id 18500734)1 Davis C.W....Gow A.J. (Pediatr. Pulmonol. 2008)
    448. Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa. (PubMed id 19120907)1 Naito Y....Yoshikawa T. (J. Gastroenterol. Hepatol. 2008)
    449. Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues. (PubMed id 18774388)1 Tremblay K....Laprise C. (J. Allergy Clin. Immunol. 2008)
    450. 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats. (PubMed id 17503181)7 Nandi J....Levine R.A. (Dig. Dis. Sci. 2008)
    451. Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation. (PubMed id 18753139)1 Marjanovic J.A....Du X. (J. Biol. Chem. 2008)
    452. Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. (PubMed id 17362916)7 Devan B.D....Ingram D.K. (Eur. J. Pharmacol. 2007)
    453. A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. (PubMed id 17475563)1 GA^mez L.M....MartA-n J. (Tuberculosis (Edinb) 2007)
    454. NOS2 regulation of NF-kappaB by S-nitrosylation of p65. (PubMed id 17720813)1 Kelleher Z.T....Marshall H.E. (J. Biol. Chem. 2007)
    455. Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations. (PubMed id 17320454)1 Falchi A....Varesi L. (Leg Med (Tokyo) 2007)
    456. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1 Harris S.E....Deary I.J. (BMC Genet. 2007)
    457. Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes. (PubMed id 18050214)1 Chockalingam P.S....Majumdar M.K. (Arthritis Rheum. 2007)
    458. Regulation of the murine inducible nitric oxide synthase gene by dexamethasone involves a heterogeneous nuclear ribonucleoprotein I (hnRNPI) dependent pathway. (PubMed id 17379310)7 SAPderberg M....Lang M.A. (Mol. Immunol. 2007)
    459. Genetic polymorphisms associated with priapism in sickle cell disease. (PubMed id 17408468)1 Elliott L....Telen M.J. (Br. J. Haematol. 2007)
    460. Genetic polymorphisms of macrophage-mediators in Guillain-BarrAc syndrome. (PubMed id 17761309)1 Geleijns K....Jacobs B.C. (J. Neuroimmunol. 2007)
    461. Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (SjAPgren's syndrome). (PubMed id 17600738)1 CejkovA! J....BrA^novA! B. (Nitric Oxide 2007)
    462. Hemodynamic and molecular response to intermittent hypoxia (IH) versus continuous hypoxia (CH) in normal humans. (PubMed id 17240318)1 Rodway G.W....Sanders M.H. (Transl Res 2007)
    463. Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners. (PubMed id 17223386)1 Qu Y....Xia Z. (Int J Hyg Environ Health 2007)
    464. The NOS3 (27-bp repeat, intron 4) polymorphism is associated with susceptibility to osteomyelitis. (PubMed id 16889995)1 Asensi V....Celada A. (Nitric Oxide 2007)
    465. Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media. (PubMed id 17908769)1 Emonts M....Sanders E.A. (Pediatrics 2007)
    466. Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11. (PubMed id 17928287)1 Berg D.T....Grinnell B.W. (J. Biol. Chem. 2007)
    467. Skeletal muscle neuronal nitric oxide synthase micro protein is reduced in people with impaired glucose homeostasis and is not normalized by exercise training. (PubMed id 17884453)1 Bradley S.J....McConell G.K. (Metab. Clin. Exp. 2007)
    468. Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression. (PubMed id 17340133)7 Kagemann G....Schnorr O. (J. Mol. Med. 2007)
    469. iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis. (PubMed id 17233833)1 Hoki Y....Kawanishi S. (Cancer Sci. 2007)
    470. Genetic polymorphisms and spontaneous preterm birth. (PubMed id 17267840)1 Gibson C.S....Nelson K.B. (Obstet Gynecol 2007)
    471. Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport. (PubMed id 17363779)7 Rotoli B.M....Bussolati O. (Am. J. Respir. Cell Mol. Biol. 2007)
    472. Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. (PubMed id 17855767)1 Uno K....Yoshimura T. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    473. Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. (PubMed id 17674321)1 de Sousa R....Walker D.H. (J. Infect. Dis. 2007)
    474. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PubMed id 17355643)1 Huang H.Y....Helzlsouer K.J. (BMC Genet. 2007)
    475. Inducible nitric oxide synthase expression is upregulated in oral submucous fibrosis. (PubMed id 17687170)1 Rajendran R. and Varkey S. (Indian J Dent Res 2007)
    476. [Expression and significance of HIF-1alpha and iNOS in human middle ear cholesteatoma epithelium]. (PubMed id 17650819)1 Zhang E. and Gong S. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007)
    477. [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. (PubMed id 17953212)1 Xia Y....Su Y. (Wei Sheng Yan Jiu 2007)
    478. Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. (PubMed id 17322004)1 Korhonen R....Kleinert H. (Mol. Pharmacol. 2007)
    479. Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease. (PubMed id 17937610)7 van Guldener C....Stehouwer C.D. (Clin. Chem. Lab. Med. 2007)
    480. Nitric oxide synthase and superoxide dismutase gene polymorphisms in BehAset disease. (PubMed id 17296902)1 Nakao K....Sakamoto T. (Arch. Ophthalmol. 2007)
    481. Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood. (PubMed id 17492662)1 Muscari C....Guarnieri C. (J. Cell. Biochem. 2007)
    482. No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes. (PubMed id 17174475)1 Huerta C....Alvarez V. (Neurosci. Lett. 2007)
    483. [Influence of iNOS silencing by RNA interference on proliferation activity of Tca8113 cell]. (PubMed id 18070432)1 Yang L....Shao J. (Zhonghua Kou Qiang Yi Xue Za Zhi 2007)
    484. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. (PubMed id 17940019)1 Hasselblatt P....Wagner E.F. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    485. Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis. (PubMed id 16937436)1 Yu J.X....Ma H.Y. (World J. Gastroenterol. 2006)
    486. Comprehensive association analysis of the NOS2A gene with Parkinson disease. (PubMed id 17159127)1 Schulte C....Gasser T. (Neurology 2006)
    487. Triflusal: an antiplatelet drug with a neuroprotective effect? (PubMed id 16939630)7 GonzA!lez-Correa J.A. and De La Cruz J.P. (Cardiovasc Drug Rev 2006)
    488. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    489. Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. (PubMed id 16543247)1 Wang S.S....Rothman N. (Carcinogenesis 2006)
    490. Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene. (PubMed id 16464859)1 Yu Z....Kone B.C. (J. Biol. Chem. 2006)
    491. Involvement of endogenous nitric oxide in the regulation of K+ channel activity in cultured human proximal tubule cells. (PubMed id 17062169)1 Nakamura K....Kubokawa M. (J Physiol Sci 2006)
    492. [Restraint stress down-regulates L-Arg/NOS/NO pathway of platelet and aortic intima in rats]. (PubMed id 16778961)7 Cui Y.Y....Geng B. (Beijing Da Xue Xue Bao 2006)
    493. Up-regulation of Fas expression by Pseudomonas aeruginosa-infected endothelial cells depends on modulation of iNOS and enhanced production of NO induced by bacterial type III secreted proteins. (PubMed id 16820946)1 Assis M.C....Plotkowski M.C. (Int. J. Mol. Med. 2006)
    494. Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells. (PubMed id 17070777)1 Ulanova M....Befus A.D. (Biochem. Biophys. Res. Commun. 2006)
    495. Inducible nitric oxide synthase and apoptosis in human B cell lymphomas. (PubMed id 16924421)1 Atik E....Tuncer I. (Mol. Cell. Biochem. 2006)
    496. [Effect of urotensin II on iNOS expression in human umbilical vein endothelial cells]. (PubMed id 21158070)1 Xu D. and Liu C.H. (Zhongguo Ying Yong Sheng Li Xue Za Zhi 2006)
    497. The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. (PubMed id 16950790)1 Pautz A....Kleinert H. (J. Biol. Chem. 2006)
    498. NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. (PubMed id 16813666)1 Kawaguchi Y....Kamatani N. (amp 2006)
    499. N-terminal palmitoylation within the appropriate amino acid environment conveys on NOS2 the ability to progress along the intracellular sorting pathways. (PubMed id 16569659)1 Navarro-LAcrida I....RodrA-guez-Crespo I. (J. Cell. Sci. 2006)
    500. NF-kappaB activity and iNOS expression in monocytes from internal jugular blood of migraine without aura patients during attacks. (PubMed id 16919057)1 Sarchielli P....Calabresi P. (Cephalalgia 2006)
    501. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    502. Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population. (PubMed id 17072962)1 Goto Y....Hamajima N. (World J. Gastroenterol. 2006)
    503. Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. (PubMed id 16771679)1 Vitek M.P....Colton C.A. (amp 2006)
    504. Association analysis of common variants of ELN, NOS2A, APOE and ACE2 to intracranial aneurysm. (PubMed id 16574921)1 Mineharu Y....Koizumi A. ( a journal of cerebral circulation 2006)
    505. Astrocytic-inducible nitric oxide synthase in the ischemic developing human brain. (PubMed id 17065568)1 Askalan R....Hawkins C. (Pediatr. Res. 2006)
    506. Gene expression changes in SNAP-stimulated and iNOS-transfected tenocytes--expression of extracellular matrix genes and its implications for tendon-healing. (PubMed id 16865710)1 Molloy T.J....Murrell G.A. (J. Orthop. Res. 2006)
    507. 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion. (PubMed id 16290060)1 Ma N....Kawanishi S. (Nitric Oxide 2006)
    508. Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity. (PubMed id 16950998)1 Sheffield M....Truog W.E. (Pediatrics 2006)
    509. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    510. [Relationship between expression of inducible nitric oxide synthase and proliferative potency of endothelium in hemangioma in infants]. (PubMed id 16573167)1 Li J.S....Cheng H.L. (Zhonghua Zheng Xing Wai Ke Za Zhi 2006)
    511. [The relationship between resting heart rate and single nucleotide polymorphism at 3 sites of nitric oxide synthase gene in the Chinese Han nationality population]. (PubMed id 17160951)1 Ma H.X....Xie Z.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    512. NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. (PubMed id 16823855)1 Hancock D.B....Scott W.K. (Ann. Neurol. 2006)
    513. Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene. (PubMed id 16105645)1 Coia V....Kun J.F. (Biochem. Biophys. Res. Commun. 2005)
    514. The RNA binding protein TIAR is involved in the regulation of human iNOS expression. (PubMed id 16191398)1 Fechir M....Kleinert H. (Cell. Mol. Biol. (Noisy-le-grand) 2005)
    515. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. (PubMed id 16352737)1 Flores-Villanueva P.O.... Granados J. (J. Exp. Med. 2005)
    516. Association of a functional inducible nitric oxide synthase promoter variant with susceptibility to biopsy-proven giant cell arteritis. (PubMed id 16265698)1 Gonzalez-Gay M.A....Martin J. (J. Rheumatol. 2005)
    517. Inducible nitric oxide synthase polymorphism is associated with susceptibility to Henoch-SchAPnlein purpura in northwestern Spain. (PubMed id 15940772)1 Martin J....Gonzalez-Gay M.A. (J. Rheumatol. 2005)
    518. Expression of inducible nitric oxide synthase in human cutaneous leishmaniasis. (PubMed id 16311916)1 Serarslan G. and Atik E. (Mol. Cell. Biochem. 2005)
    519. Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells. (PubMed id 15631944)1 Cui Z....Baydoun A.R. (Nitric Oxide 2005)
    520. Expression of nitric oxide synthases in parathyroid gland adenoma and parathyroid gland hyperplasia. (PubMed id 16136006)1 Kucera T....Astl J. (Neuro Endocrinol. Lett. 2005)
    521. Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction. (PubMed id 15784171)1 Heltianu C....Simionescu M. (J. Cell. Mol. Med. 2005)
    522. Soluble amyloid beta-peptide and myelin basic protein strongly stimulate, alone and in synergism with combined proinflammatory cytokines, the expression of functional nitric oxide synthase-2 in normal adult human astrocytes. (PubMed id 16211247)1 Chiarini A....Armato U. (Int. J. Mol. Med. 2005)
    523. Ischemic preconditioning modulates the expression of several genes, leading to the overproduction of IL-1Ra, iNOS, and Bcl-2 in a human model of liver ischemia-reperfusion. (PubMed id 16195370)1 Barrier A....Lemoine A. (FASEB J. 2005)
    524. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. (PubMed id 16126846)1 Linker K....Kleinert H. (Nucleic Acids Res. 2005)
    525. Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (PubMed id 15654505)1 Liu Y....Tsugane S. (J. Hum. Genet. 2005)
    526. The promoter of inducible nitric oxide synthase implicated in glaucoma based on genetic analysis and nuclear factor binding. (PubMed id 16288199)1 Motallebipour M....Wadelius C. (Mol. Vis. 2005)
    527. Expression of mRNA for inducible NO synthase in human brain. (PubMed id 16282997)1 Smolina I.V....Rasskazov V.A. (Bull. Exp. Biol. Med. 2005)
    528. Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer. (PubMed id 15922861)1 FransAcn K....SAPderkvist P. (Cancer Lett. 2005)
    529. Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity. (PubMed id 15349722)1 Westerholt A....Heidecke C.D. (Transpl. Int. 2004)
    530. The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. (PubMed id 15054088)7 Fogli S....Breschi M.C. (FASEB J. 2004)
    531. iNOS promoter variants and severe malaria in Ghanaian children. (PubMed id 15482399)1 Cramer J.P....Bienzle U. (amp 2004)
    532. Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B. (PubMed id 15100320)1 Jaramillo M....Olivier M. (J. Immunol. 2004)
    533. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    534. Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors. (PubMed id 15205363)1 Nishikawa M....Inoue M. (Carcinogenesis 2004)
    535. Reduced expression of endothelial and inducible nitric oxide synthase in a multidrug resistant variant of the MCF-7 human breast cancer cell line. (PubMed id 15492785)1 Lahiri M. and Martin J.H. (Oncol. Rep. 2004)
    536. Relation of hypoxia-inducible factor-1alpha to vascular endothelial growth factor and vasoactive factors during healing of gastric ulcers. (PubMed id 15838334)1 Hashimoto H....Yamashito K. (J. Cardiovasc. Pharmacol. 2004)
    537. Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. (PubMed id 15271950)1 Keller C.C....Perkins D.J. (Infect. Immun. 2004)
    538. Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection. (PubMed id 14985675)1 Yee L.J....Thursz M.R. (Genes Immun. 2004)
    539. Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest. (PubMed id 15180967)1 Rudnick J....Blottner D. (FASEB J. 2004)
    540. Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity. (PubMed id 15285794)1 Walsh K.A....Hammond R.R. (J Neuroinflammation 2004)
    541. Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture. (PubMed id 15026539)1 Quattrone S....Bani D. (Mol. Hum. Reprod. 2004)
    542. Host polymorphisms and the incidence of malaria in Ugandan children. (PubMed id 15642965)1 Parikh S....Rosenthal P.J. (Am. J. Trop. Med. Hyg. 2004)
    543. [Polymorphism of NOS2A promoter -969(G&gt;C) is associated with portal hypertension of liver cirrhosis]. (PubMed id 15583989)1 Cheng Y.Q....Jiang X.D. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004)
    544. Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms. (PubMed id 14715665)1 Gao Y.T....Salerno J.C. (J. Biol. Chem. 2004)
    545. Down-regulation of inducible nitric oxide synthase by lysophosphatidic acid in human respiratory epithelial cells. (PubMed id 15532709)1 Kadowaki S....Shimizu E. (Mol. Cell. Biochem. 2004)
    546. Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men. (PubMed id 15494775)1 Imamura A....Murohara T. (Can J Cardiol 2004)
    547. Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease. (PubMed id 14764920)1 Yu X....Miyawaki T. (Pediatr. Res. 2004)
    548. Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. (PubMed id 12508391)1 Oates J.C....Gilkeson G.S. (J. Rheumatol. 2003)
    549. Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease. (PubMed id 12709136)1 Khajoee V....Hara T. (Pediatr Int 2003)
    550. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1 Lee J.K....Jo I. (J. Hum. Genet. 2003)
    551. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. (PubMed id 12816735)1 Barreiro E....Hussain S.N. (Am. J. Respir. Cell Mol. Biol. 2003)
    552. Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. (PubMed id 14740870)1 Boutlis C.S....Anstey N.M. (Am. J. Trop. Med. Hyg. 2003)
    553. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. (PubMed id 12641410)1 Mombo L.E....Krishnamoorthy R. (Am. J. Trop. Med. Hyg. 2003)
    554. Increased inducible nitric oxide synthase expression and nitric oxide concentration in patients with aplastic anemia. (PubMed id 12601489)1 Chung I.J....Kim H.J. (Ann. Hematol. 2003)
    555. Inducible nitric oxide synthase (NOS II) is constitutive in human neutrophils. (PubMed id 14616549)1 Cedergren J....Skogh T. (APMIS 2003)
    556. No significant correlation exists between nitric oxide production and apoptosis in myelodysplastic syndromes. (PubMed id 12486325)1 Choi J.W. (Acta Haematol. 2003)
    557. Expression of nitric oxide synthase isoforms in the human placenta is not altered by labor. (PubMed id 14614209)1 Kakui K....Fujii S. (Endocr. J. 2003)
    558. Fire ant venom alkaloid, isosolenopsin A, a potent and selective inhibitor of neuronal nitric oxide synthase. (PubMed id 12745988)7 Yi G.B....Rockhold R.W. (Int. J. Toxicol. 2003)
    559. In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits. (PubMed id 12690222)1 Zanetti M....O'Brien T. ( a journal of cerebral circulation 2003)
    560. Intracellular formation of &quot;undisruptable&quot; dimers of inducible nitric oxide synthase. (PubMed id 14614131)1 Kolodziejski P.J....Eissa N.T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    561. A critical role for C/EBPbeta binding to the AABS promoter response element in the human iNOS gene. (PubMed id 12958187)1 Guo Z....Geller D.A. (FASEB J. 2003)
    562. Inducible nitric oxide synthase promoter polymorphism in human brucellosis. (PubMed id 14623011)1 Orozco G....MartA-n J. (Microbes Infect. 2003)
    563. Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells. (PubMed id 12948935)1 Kreiselmeier N.E....Kelley T.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003)
    564. Induction of nitric oxide synthase in RAW 264.7 macrophages by lipoteichoic acid from Staphylococcus aureus: involvement of protein kinase C- and nuclear factor-kB-dependent mechanisms. (PubMed id 12607534)1 Kuo C.T....Lin C.H. (J. Biomed. Sci. 2003)
    565. Hepatitis C virus core protein transactivates the inducible nitric oxide synthase promoter via NF-kappaB activation. (PubMed id 14638407)1 de Lucas S....CarreA+o V. (Antiviral Res. 2003)
    566. Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples. (PubMed id 14634838)1 Yoshimura K....Tsugane S. (J. Hum. Genet. 2003)
    567. Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations. (PubMed id 14551604)1 Burgner D....Kwiatkowski D.P. (Genes Immun. 2003)
    568. The inducible nitric oxide synthase promoter polymorphism does not confer susceptibility to systemic lupus erythematosus. (PubMed id 12509623)1 LA^pez-Nevot M.A....MartA-n J. (Rheumatology (Oxford) 2003)
    569. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. (PubMed id 12855682)1 Yoshida M. and Xia Y. (J. Biol. Chem. 2003)
    570. Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4. (PubMed id 12960352)1 Daniliuc S....Nitza L. (J. Immunol. 2003)
    571. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1 Watanabe I....Koga T. (Clin. Pharmacol. Ther. 2003)
    572. STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation. (PubMed id 12788789)1 Xu W....Erzurum S.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003)
    573. Undetectable levels of tumor necrosis factor-alpha, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism. (PubMed id 12799216)1 RodrA-guez-Arnao M.D....MuA+oz-FernA!ndez M.A. (Eur. Cytokine Netw. 2003)
    574. Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children. (PubMed id 12631094)1 VallAcs P.G....RA1ttler M. (Kidney Int. 2003)
    575. Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy. (PubMed id 12828935)1 Liu B. and Neufeld A.H. (Neurobiol. Dis. 2003)
    576. Helicobacter pylori infection activates NF-kappaB signaling pathway to induce iNOS and protect human gastric epithelial cells from apoptosis. (PubMed id 12919943)1 Kim J.M....Song I.S. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003)
    577. No evidence for association of the inducible nitric oxide synthase promoter polymorphism with Trypanosoma cruzi infection. (PubMed id 12135432)1 Calzada J.E....MartA-n J. (Tissue Antigens 2002)
    578. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. (PubMed id 12237122)1 Yanagita M....Murakami S. (Biochem. Biophys. Res. Commun. 2002)
    579. Nitric oxide synthase-cyclooxygenase interactions are involved in tumor cell angiogenesis and migration. (PubMed id 12462194)1 Davel L....Sales M.E. (J. Biol. Regul. Homeost. Agents 2002)
    580. Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. (PubMed id 12125143)1 Saunders J.R....Anstey N.M. (Methods Mol. Med. 2002)
    581. Detection of iNOS gene expression in cutaneous leishmaniasis biopsy tissue. (PubMed id 11985871)1 Arevalo I....Matlashewski G. (Mol. Biochem. Parasitol. 2002)
    582. Immunolocalization of inducible nitric oxide synthase in localized juvenile periodontitis patients. (PubMed id 12489192)1 Gaspirc B....Skaleric U. (Connect. Tissue Res. 2002)
    583. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: the role of NF-kappa B- repressing factor (NRF) in basal repression of the hiNOS gene. (PubMed id 12381793)1 Feng X....Geller D.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    584. Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia. (PubMed id 12167619)1 Liu X....Pahan K. (J. Biol. Chem. 2002)
    585. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    586. Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide. (PubMed id 12060397)1 Fecker L.F....Geilen C.C. (J. Invest. Dermatol. 2002)
    587. Association of a functional inducible nitric oxide synthase promoter variant with complications in type 2 diabetes. (PubMed id 11907646)1 Morris B.J....Wang L. (J. Mol. Med. 2002)
    588. Analysis of nitric oxide synthase genes in cluster headache. (PubMed id 12421162)1 SjAPstrand C....Hillert J. (Cephalalgia 2002)
    589. Citrulline is not the major product using the standard &quot;NOS activity&quot; assay on renal cortical homogenates. (PubMed id 11742852)7 Conrad K.P....Novak J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002)
    590. Prostacyclin enhances the expression of LPS/INF-gamma-induced nitric oxide synthase in human monocytes. (PubMed id 12119468)1 Plum J....Meyer-Kirchrath J. (Nephron 2002)
    591. Expression of nitric oxide synthase isoforms in human pregnant myometrium at term. (PubMed id 12445599)1 Bao S....Schreiber J. (J. Soc. Gynecol. Investig. 2002)
    592. Inducible nitric oxide synthase expression in chronic viral hepatitis and its relation with histological severity of disease. (PubMed id 12431203)1 Kandemir O....Kaya A. (J. Viral Hepat. 2002)
    593. Expression of inducible nitric oxide synthase in skin lesions of patients with american cutaneous leishmaniasis. (PubMed id 12117977)1 Qadoumi M....Bogdan C. (Infect. Immun. 2002)
    594. [A short tandem repeat polymorphism in the inducible nitric oxide synthase gene in Chinese population]. (PubMed id 11985259)1 LA1 X....Zheng X.F. (Yi Chuan Xue Bao 2002)
    595. Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas. (PubMed id 12459168)1 Gallo O....Franchi A. (Biochem. Biophys. Res. Commun. 2002)
    596. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
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    598. PKC-zeta prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity. (PubMed id 12223351)1 Banan A....Keshavarzian A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002)
    599. Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. (PubMed id 12085352)1 Stolz D.B....Watkins S.C. (Hepatology 2002)
    600. Endothelial nitric oxide synthase and caveolin-1 are co-localized in sinusoidal endothelial fenestrae. (PubMed id 11422783)1 Yokomori H....Ishii H. (Liver 2001)
    601. No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine. (PubMed id 11424980)1 Lea R.A....Griffiths L.R. (Am. J. Med. Genet. 2001)
    602. Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease. (PubMed id 11294696)1 Morris B.J....Wang X.L. (Clin. Sci. 2001)
    603. No linkage or association of the nitric oxide synthase genes to multiple sclerosis. (PubMed id 11525805)1 Modin H....Hillert J. (J. Neuroimmunol. 2001)
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    606. Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol. (PubMed id 11579140)1 Bruce-Keller A.J....Nath A. (J. Neurochem. 2001)
    607. The specific NOS2 inhibitor, 1400W, sensitizes HepG2 cells to genotoxic, oxidative, xenobiotic, and endoplasmic reticulum stresses. (PubMed id 11761338)1 Payne C.M....Garewal H. (amp 2001)
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    611. Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. (PubMed id 11050162)1 Hussain S.P....Harris C.C. (Proc. Natl. Acad. Sci. U.S.A. 2000)
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    613. Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. (PubMed id 11114180)1 Felley-Bosco E....Quest A.F. (Proc. Natl. Acad. Sci. U.S.A. 2000)
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    616. Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident. (PubMed id 10842192)1 Romanenko A....Fukushima S. (Int. J. Cancer 2000)
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    633. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. (PubMed id 7528106)1 Mannick J.B.... Stamler J.S. (Cell 1994)
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    637. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. (PubMed id 8383325)1 Corbett J.A....McDaniel M.L. (Proc. Natl. Acad. Sci. U.S.A. 1993)
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    643. Inducible nitric oxide synthase expression in various laryngeal lesions in relation to carcinogenesis, angiogenesis, and patients' prognosis. (PubMed id 17712678)9 Shigyo H....Harabuchi Y. (Acta Otolaryngol. 2007)
    644. Inducible nitric oxide synthase (iNOS) expression and its prognostic value in prostate cancer. (PubMed id 11712818)9 Aaltoma S.H....Kosma V.M. (Anticancer Res. 2001)
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    649. Increased expression of inducible nitric oxide synthase for human buccal squamous-cell carcinomas: immunohistochemical, reverse transcription-polymerase chain reaction (RT-PCR) and in situ RT-PCR studies. (PubMed id 12369071)9 Chen Y.K....Lin L.M. (amp 2002)
    650. Inducible nitric oxide synthase expression in benign and malignant cutaneous melanocytic lesions. (PubMed id 11400148)9 Massi D....Santucci M. (J. Pathol. 2001)
    651. Detection of an approximately 100 kD protein with strong immunoreactivity to antibodies specific for inducible nitric oxide synthase (iNOS) but without NOS activity in neutrophils of patients suffering from sepsis: results of a preliminary study. (PubMed id 10669117)9 Richter N....Schimke I. (Inflamm. Res. 1999)
    652. Inducible nitric oxide synthase (iNOS) in the human heart: expression and localization in congestive heart failure. (PubMed id 9689595)9 Vejlstrup N.G....Aldershvile J. (J. Mol. Cell. Cardiol. 1998)
    653. Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli. (PubMed id 18039960)9 Sareila O....Moilanen E. (J. Pharmacol. Exp. Ther. 2008)
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    656. Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. (PubMed id 16957516)9 Bonderup O.K....Teglbjaerg P.S. (amp 2006)
    657. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. (PubMed id 16900533)9 Chen C.N....Lee P.H. (J Surg Oncol 2006)
    658. Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets. (PubMed id 16581191)9 Mishra O.P....Delivoria-Papadopoulos M. (Neuroscience 2006)
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    660. Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma. (PubMed id 15743688)9 Connelly S.T....Schmidt B.L. (Oral Oncol. 2005)
    661. Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability. (PubMed id 15528042)9 Won J.S....Singh I. (amp 2004)
    662. Sequential expression of inducible nitric oxide synthase and cyclooxygenase-2 during DMBA-induced hamster buccal pouch carcinogenesis. (PubMed id 15523901)9 Kim S.A....Yoon J.H. (In Vivo 2004)
    663. Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor. (PubMed id 15133224)9 Ueda S....Ido M. (amp 2004)
    664. Inducible nitric oxide synthase in the bladder of spinal cord injured patients with a chronic indwelling urinary catheter. (PubMed id 11342896)9 Wall B.M....Cooke C.R. (J. Urol. 2001)
    665. Phorbol ester synergistically increases interferon regulatory factor-1 and inducible nitric oxide synthase induction in interferon-gamma-treated RAW 264.7 cells. (PubMed id 11042347)9 Momose I....Tanigawa Y. (Biochim. Biophys. Acta 2000)
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    667. Expression of inducible nitric oxide synthase in colorectal cancer and its association with prognosis. (PubMed id 11145294)9 Ropponen K.M....Kosma V.M. (Scand. J. Gastroenterol. 2000)
    668. Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors. (PubMed id 11076874)9 Cavicchi M....Whittle B.J. (Gut 2000)
    669. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. (PubMed id 10348815)9 Fu S....Wilson K.T. (Gastroenterology 1999)
    670. Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines. (PubMed id 9771406)9 Kolios G....Westwick J. (Gut 1998)
    671. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. (PubMed id 9679948)9 Wilson K.T....Meltzer S.J. (Cancer Res. 1998)
    672. Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. (PubMed id 9426743)9 Seftel A.D....Haas C. (Urology 1997)
    673. Regulation of nitric oxide synthesis in uraemia. (PubMed id 8538931)9 Arese M....Bussolino F. (Nephrol. Dial. Transplant. 1995)
    674. L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor. (PubMed id 16717106)9 Yang J....Zhang C. (J. Pharmacol. Exp. Ther. 2006)
    675. Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma. (PubMed id 16273602)9 Sun M.H....Jiang Y. (World J. Gastroenterol. 2005)
    676. Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes. (PubMed id 16172396)9 Loughran P.A....Billiar T.R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    677. Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells. (PubMed id 15718251)9 Chen J....Huang C. (Carcinogenesis 2005)
    678. Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: evidence for a transcriptional mechanism. (PubMed id 15282113)9 Davis R.L. and Syapin P.J. (Alcohol 2004)
    679. Stimulation of inducible nitric oxide synthase by monosodium urate crystals in macrophages and expression of iNOS in gouty arthritis. (PubMed id 15566969)9 Chen L....Tsai S.H. (Nitric Oxide 2004)
    680. Antifibrotic role of inducible nitric oxide synthase. (PubMed id 12009846)9 Ferrini M.G....Gonzalez-Cadavid N.F. (Nitric Oxide 2002)
    681. A specific method for measurement of nitric oxide synthase enzymatic activity in peritoneal biopsies. (PubMed id 10620216)9 Combet S....Devuyst O. (Kidney Int. 2000)
    682. Therapeutic stimulation of penile nitric oxide synthase (NOS) and related pathways. (PubMed id 12879114)9 Gonzalez-Cadavid N.F. and Rajfer J. (Drugs Today 2000)
    683. Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: influence of cell differentiation. (PubMed id 10516652)9 Cavicchi M. and Whittle B.J. (Br. J. Pharmacol. 1999)
    684. Induction of inducible nitric oxide synthase is an essential part of tumor necrosis factor-alpha-induced apoptosis in MCF-7 and other epithelial tumor cells. (PubMed id 10616218)9 Binder C....Oellerich M. ( a journal of technical methods and pathology 1999)
    685. Hemodialysis hypotension: interaction of inhibitors, iNOS, and the interdialytic period. (PubMed id 9892267)9 Kang E.S....Acchiardo S.R. (Am. J. Med. Sci. 1999)
    686. The detection and localization of inducible nitric oxide synthase production in the small intestine of patients with coeliac disease. (PubMed id 9744691)9 Beckett C.G....Ciclitira P.J. (amp 1998)
    687. Regulation of the urea cycle enzyme genes in nitric oxide synthesis. (PubMed id 9686345)9 Mori M....Sonoki T. (J. Inherit. Metab. Dis. 1998)
    688. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. (PubMed id 9754830)9 Darville M.I. and Eizirik D.L. (Diabetologia 1998)
    689. Expression of differential nitric oxide synthase isoforms in human normal gastric mucosa and gastric cancer tissue. (PubMed id 9328184)9 Rajnakova A....Moochhala S. (Carcinogenesis 1997)
    690. Nitric oxide synthase content of hypothalamic explants: increase by norepinephrine and inactivated by NO and cGMP. (PubMed id 8633049)9 Canteros G....McCann S.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    691. Nitric oxide synthase in circulating vs. extravasated polymorphonuclear leukocytes. (PubMed id 7595064)9 Miles A.M....Grisham M.B. (J. Leukoc. Biol. 1995)
    692. Expression of inducible nitric oxide synthase in conduits used in patients with diabetes mellitus undergoing coronary revascularization. (PubMed id 19811579)9 Lazar H.L....Chipkin S. (J Card Surg 2010)
    693. Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells. (PubMed id 19398497)9 Kang J.H....Kim M.J. (J. Endocrinol. 2009)
    694. Extracts of Magnoliae flos inhibit inducible nitric oxide synthase via ERK in human respiratory epithelial cells. (PubMed id 18976718)9 Baek J.A....Na D.J. (Nitric Oxide 2009)
    695. Overexpression of hepatic inducible nitric oxide synthase in biliary atresia. (PubMed id 18564140)9 Vejchapipat P....Poovorawan Y. (Hepatol. Res. 2008)
    696. Prognostic significance of iNOS in epithelial ovarian cancer. (PubMed id 17174383)9 Anttila M.A....Kosma V.M. (Gynecol. Oncol. 2007)
    697. Chemotherapy influences inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) activity on 3D breast cancer cell line. (PubMed id 17120617)9 Oktem G....Omay S.B. (Oncol. Res. 2006)
    698. Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma. (PubMed id 15750198)9 Li W....Fan B. (Med. Oncol. 2005)
    699. Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures. (PubMed id 16165295)9 Duport S. and Garthwaite J. (Neuroscience 2005)
    700. Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells. (PubMed id 16148131)9 Chan G.C....Marsden P.A. (J. Immunol. 2005)
    701. Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification. (PubMed id 15656623)9 Zhu Y....Silverman R.B. (J. Am. Chem. Soc. 2005)
    702. The influence of uropathogenic Escherichia coli and proinflammatory cytokines on the inducible nitric oxide synthase response in human kidney epithelial cells. (PubMed id 15711365)9 Poljakovic M....Persson K. (J. Urol. 2005)
    703. Palmitoylation of inducible nitric-oxide synthase at Cys-3 is required for proper intracellular traffic and nitric oxide synthesis. (PubMed id 15485846)9 Navarro-LAcrida I....RodrA-guez-Crespo I. (J. Biol. Chem. 2004)
    704. Phenotypic modulation of cultured bladder smooth muscle cells and the expression of inducible nitric oxide synthase. (PubMed id 14656765)9 Johansson R. and Persson K. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004)
    705. Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells. (PubMed id 15498507)9 Jang B.C....Suh S.I. (Biochem. Pharmacol. 2004)
    706. Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia. (PubMed id 14719508)9 Hong S.K....Seow H.F. (Asian J Surg 2004)
    707. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. (PubMed id 14984945)9 Raspollini M.R....Taddei G.L. (Gynecol. Oncol. 2004)
    708. Chronic gastritis with expression of inducible nitric oxide synthase is associated with high expression of interleukin-6 and hypergastrinaemia. (PubMed id 15191513)9 Kai H....Chayama K. (amp 2004)
    709. Inducible nitric oxide synthase expression is related to angiogenesis, bcl-2 and cell proliferation in hepatocellular carcinoma. (PubMed id 12659238)9 Peng J.P....Zhang S.Z. (J. Zhejiang Univ. Sci. 2003)
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    711. Nitric oxide in experimental joint inflammation. Benefit or detriment? (PubMed id 12784039)9 Wahl S.M....Orenstein J.M. (Cells Tissues Organs (Print) 2003)
    712. Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis. (PubMed id 12678336)9 Kankuri E....Moilanen E. (Scand. J. Gastroenterol. 2003)
    713. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. (PubMed id 12460898)9 Kisley L.R....Malkinson A.M. (Cancer Res. 2002)
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    715. Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus. (PubMed id 11589878)9 Abu El-Asrar A.M....Geboes K. (Am. J. Ophthalmol. 2001)
    716. Differential expression and regulation of inducible nitric oxide synthase (iNOS) mRNA in human trophoblasts in vitro. (PubMed id 11216878)9 Hambartsoumian E....Seibel M.M. (Am. J. Reprod. Immunol. 2001)
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    722. Identification of residues critical for enzymatic activity in the domain encoded by exons 8 and 9 of the human inducible nitric oxide synthase. (PubMed id 11350832)9 Eissa N.T....Moss J. (Am. J. Respir. Cell Mol. Biol. 2001)
    723. Expression of the inducible isoform of nitric oxide synthase in pigment cell lesions of the skin. (PubMed id 10735946)9 Ahmed B. and Van Den Oord J.J. (Br. J. Dermatol. 2000)
    724. Maturation-dependent sequential expression of interferon regulatory factor-1 and inducible nitric oxide synthase in cultured human enterocytes. (PubMed id 11092683)9 Bernstein T....Salzman A.L. (Shock 2000)
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    727. Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. (PubMed id 10589693)9 Datta P.K....Lianos E.A. (J. Am. Soc. Nephrol. 1999)
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    729. Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. (PubMed id 10073969)9 Baker C.S....Polak J.M. (Arterioscler. Thromb. Vasc. Biol. 1999)
    730. Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine. (PubMed id 9538001)9 Bryk R. and Wolff D.J. (Biochemistry 1998)
    731. Expression of inducible nitric oxide synthase in human burn wounds. (PubMed id 9776857)9 Paulsen S.M....Nanney L.B. (Wound Repair Regen 1998)
    732. Expression of inducible nitric oxide synthase (iNOS) mRNA in inflamed esophageal and colonic mucosa in a pediatric population. (PubMed id 9625130)9 Gupta S.K....Garcia J.G. (Am. J. Gastroenterol. 1998)
    733. Inducible nitric oxide synthase and tumor necrosis factor-alpha in myocardium in human dilated cardiomyopathy. (PubMed id 9091515)9 Satoh M....Hiramori K. (J. Am. Coll. Cardiol. 1997)
    734. Characterization of inducible nitric-oxide synthase by cytochrome P-450 substrates and inhibitors. Inhibition by chlorzoxazone. (PubMed id 8995391)9 Grant S.K....Kozarich J.W. (J. Biol. Chem. 1997)
    735. Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. (PubMed id 9096878)9 GarbA!n H....GonzA!lez-Cadavid N.F. (Biol. Reprod. 1997)
    736. Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells. (PubMed id 8751576)9 de Vera M.E....Geller D.A. (Surgery 1996)
    737. Proinflammatory agents, IL-8 and IL-10, upregulate inducible nitric oxide synthase expression and nitric oxide production in avian osteoclast-like cells. (PubMed id 8707887)9 Sunyer T....Collin-Osdoby P. (J. Cell. Biochem. 1996)
    738. Nitric oxide synthase in motor neurons after axotomy. (PubMed id 7510317)9 Yu W.H. (J. Histochem. Cytochem. 1994)
    739. Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. (PubMed id 19854161)9 Schmidt N....Kleinert H. (Biochem. Pharmacol. 2010)
    740. Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. (PubMed id 17936042)9 Habara K....Okumura T. (Nitric Oxide 2008)
    741. Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno-purified human monocytes. (PubMed id 17543124)9 Skorokhod O.A....Arese P. (Malar. J. 2007)
    742. Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. (PubMed id 17122636)9 Cunha I.W....Soares F.A. (amp 2006)
    743. [Expression of cyclooxygenase-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma]. (PubMed id 16552960)9 Xu G.X....Pan C.B. (Ai Zheng 2005)
    744. Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide. (PubMed id 15476266)9 Dijkstra G....Moshage H. (J. Pathol. 2004)
    745. Inducible nitric oxide synthase (iNOS) is expressed similarly in multiple aberrant crypt foci and colorectal tumors from the same patients. (PubMed id 11212223)9 Hao X.P....Pretlow T.P. (Cancer Res. 2001)
    746. Quercetin tetraacetyl derivative inhibits LPS-induced nitric oxide synthase (iNOS) expression in J774A.1 cells. (PubMed id 20417174)9 Ortega M.G....Chiabrando G.A. (Arch. Biochem. Biophys. 2010)
    747. Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. (PubMed id 19300368)9 Sappayatosok K....Chaisri U. (Med Oral Patol Oral Cir Bucal 2009)
    748. Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis. (PubMed id 18660796)9 Massi D....Miracco C. (Mod. Pathol. 2009)
    749. Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells. (PubMed id 20388956)9 Jang S.H....Kim H. (J. Physiol. Pharmacol. 2009)
    750. The effects of PDTC on interleukin-1beta-induced nitric oxide production in chondrocytes. (PubMed id 19513610)9 Liu J....Li X. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2009)
    751. Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial-derived S100B protein. (PubMed id 19558426)9 Cirillo C....Cuomo R. (Neurogastroenterol. Motil. 2009)
    752. Chitosomes loaded with cranberry proanthocyanidins attenuate the bacterial lipopolysaccharide-induced expression of iNOS and COX-2 in raw 264.7 macrophages. (PubMed id 19694605)9 Madrigal-Carballo S....Molina F. (J Liposome Res 2009)
    753. Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. (PubMed id 18567803)9 Lee H.C....Hong S.I. (Mol. Cancer Res. 2008)
    754. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. (PubMed id 18022235)9 Ashino T....Yoshida T. (Mol. Immunol. 2008)
    755. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. (PubMed id 18481332)9 Pae H.O....Chung H.T. (amp 2008)
    756. Sympathetic neurotransmission modulates expression of inflammatory markers in the rat retina. (PubMed id 17067575)9 Steinle J.J. (Exp. Eye Res. 2007)
    757. L-arginine prevents reduced expression of endothelial nitric oxide synthase (NOS) in pulmonary arterioles of broilers exposed to cool temperatures. (PubMed id 16169754)9 Tan X....Wang X.L. (Vet. J. 2007)
    758. The cardioprotective effects of thoracal epidural anestesia are induced by the expression of vascular endothelial growth factor and inducible nitric oxide synthase in cardiopulmonary bypass surgery. (PubMed id 17308528)9 Gonca S....Bayindir O. (J Cardiovasc Surg (Torino) 2007)
    759. [Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]. (PubMed id 17988548)9 Huo J.M....Shi Y.Z. (Zhonghua Jie He He Hu Xi Za Zhi 2007)
    760. [Ovarian steroid cell tumor, not otherwise specified: a clinicopathologic study]. (PubMed id 17980097)9 Ye L....Yang K.X. (Zhonghua Bing Li Xue Za Zhi 2007)
    761. Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells' degeneration induced by inflammatory processes after lipopolysaccharide injection. (PubMed id 16713109)9 Ruano D....CastaA+o A. (Neuroscience 2006)
    762. Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. (PubMed id 17179688)9 Kim K.H....Kim J.M. (J. Korean Med. Sci. 2006)
    763. Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure. (PubMed id 16803456)9 Dover A.R....Newby D.E. (Clin. Sci. 2006)
    764. [Inhibitory effect of cholecystokinin octapeptide on lipopolysaccharide-elicited inducible nitric oxide synthase expression in vascular endothelial cells]. (PubMed id 16512640)9 Yan J....Ling Y.L. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006)
    765. Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms. (PubMed id 16765486)9 Pannu R. and Singh I. (Neurochem. Int. 2006)
    766. Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle. (PubMed id 15563630)9 Schrage W.G....Joyner M.J. (J. Appl. Physiol. 2005)
    767. Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production. (PubMed id 15740980)9 Srisook K. and Cha Y.N. (Nitric Oxide 2005)
    768. Differential effects of anesthetics on endotoxin-induced liver injury. (PubMed id 15824646)9 Suliburk J.W....Mercer D.W. (J Trauma 2005)
    769. Catalase induced expression of inflammatory mediators via activation of NF-kappaB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia. (PubMed id 15683737)9 Jang B.C....Suh S.I. (Cell. Signal. 2005)
    770. Biochemical aspects of nitric oxide. (PubMed id 15134561)9 Mariotto S....Suzuki H. (Curr. Pharm. Des. 2004)
    771. Regulation of inducible nitric oxide synthase expression in advanced glycation end product-stimulated raw 264.7 cells: the role of heme oxygenase-1 and endogenous nitric oxide. (PubMed id 15220209)9 Sumi D. and Ignarro L.J. (Diabetes 2004)
    772. [The expression of VEGF and iNOS in laryngeal squamous cell carcinoma and its clinical significance]. (PubMed id 15831042)9 Sun N. and Ge R. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2004)
    773. Effect of montelukast pretreatment on inducible nitric oxide synthase mRNA expression in the lungs of antigen-challenged allergic mice. (PubMed id 14656364)9 Sade K....Kivity S. (Clin. Exp. Allergy 2003)
    774. Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease. (PubMed id 12504936)9 Wang X....Trudinger B. (BJOG 2003)
    775. Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis. (PubMed id 12016107)9 Scott J.A....McCormack D.G. (Am. J. Respir. Crit. Care Med. 2002)
    776. Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage. (PubMed id 11597171)9 Vuolteenaho K....Moilanen E. (Osteoarthr. Cartil. 2001)
    777. Altered arterial expression patterns of inducible and endothelial nitric oxide synthase in pulmonary plexogenic arteriopathy caused by congenital heart disease. (PubMed id 11371423)9 Berger R.M....Mooi W.J. (Am. J. Respir. Crit. Care Med. 2001)
    778. Are myoepithelial cells responsible for the widespread expression of inducible nitric oxide synthase in pleomorphic adenoma? An immunohistochemical study. (PubMed id 10890559)9 Brennan P.A....Downie I.P. (amp 2000)
    779. Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. (PubMed id 11156233)9 Ekmekcioglu S....Grimm E.A. (Clin. Cancer Res. 2000)
    780. Mutations at lysine 525 of inducible nitric-oxide synthase affect its Ca2+-independent activity. (PubMed id 10978319)9 Lee S.J....Stull J.T. (J. Biol. Chem. 2000)
    781. Expression of the inducible NO synthase in human monocytic U937 cells allows high output nitric oxide production. (PubMed id 9886246)9 Bertholet S....MauAl J. (J. Leukoc. Biol. 1999)
    782. Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection. (PubMed id 9822514)9 Hsu C.D....Parkash V. (Am. J. Obstet. Gynecol. 1998)
    783. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. (PubMed id 9464988)9 Bhat N.R....Hogan E.L. (J. Neurosci. 1998)
    784. Transfection of inducible nitric oxide synthase gene causes apoptosis in vascular smooth muscle cells. (PubMed id 9743513)9 Iwashina M....Hirata Y. (Circulation 1998)
    785. Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. (PubMed id 9671763)9 Ambs S....Harris C.C. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    786. Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma. (PubMed id 9877390)9 Di Cesare P.E....Amin A.R. (J. Orthop. Res. 1998)
    787. Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo. (PubMed id 9118670)9 Liu S.F....Evans T.W. (Crit. Care Med. 1997)
    788. Relationships between NADPH diaphorase staining and neuronal, endothelial, and inducible nitric oxide synthase and cytochrome P450 reductase immunoreactivities in guinea-pig tissues. (PubMed id 9049638)9 Young H.M....Tracey W.R. (Histochem. Cell Biol. 1997)
    789. Tyrosine kinases are involved with the expression of inducible nitric oxide synthase in human articular chondrocytes. (PubMed id 7539812)9 Geng Y....Lotz M. (J. Cell. Physiol. 1995)
    790. Cerebral and peripheral changes occurring in nitric oxide (NO) synthesis in a rat model of sleeping sickness: identification of brain iNOS expressing cells. (PubMed id 20169057)9 Amrouni D....Cespuglio R. (PLoS ONE 2010)
    791. Expression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breast. (PubMed id 20174726)9 Atik E....Aban N. (Saudi Med J 2010)
    792. COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro. (PubMed id 19371268)9 Huang C.Y....Ho L.J. (Eur. J. Clin. Invest. 2009)
    793. The impact of intracellular generation of nitric oxide on the radiation response of human tumor cells. (PubMed id 19580492)9 Singh S....Stratford I.J. (Radiat. Res. 2009)
    794. The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine-stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells. (PubMed id 19961388)9 Kim Y.S....Kim E.C. (J. Periodontol. 2009)
    795. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. (PubMed id 19198806)9 Zhang X....Zhong L. (Naunyn Schmiedebergs Arch. Pharmacol. 2009)
    796. Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells. (PubMed id 17851925)9 Arai S....Yamashita T. (Acta Otolaryngol. 2008)
    797. Distinct inflammatory properties of late-activated macrophages in inflammatory myopathies. (PubMed id 19364061)9 Rostasy K.M....Schulz-Schaeffer J. (Acta Myol 2008)
    798. Gene therapy via inducible nitric oxide synthase: a tool for the treatment of a diverse range of pathological conditions. (PubMed id 18644193)9 McCarthy H.O....Hirst D.G. (J. Pharm. Pharmacol. 2008)
    799. [Relationship of nitric oxide and nitric oxide synthase with varicocele infertility]. (PubMed id 18572859)9 Xu Y....Peng Y.F. (Zhonghua Nan Ke Xue 2008)
    800. Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. (PubMed id 17913526)9 HAomAolAoinen M....Moilanen E. (amp 2008)
    801. Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets. (PubMed id 18606420)9 O'Kane P.D....Ferro A. (J. Mol. Cell. Cardiol. 2008)
    802. Estradiol 17-beta and progesterone modulate inducible nitric oxide synthase and high mobility group box 1 expression in human endometrium. (PubMed id 18483013)9 Zicari A....Ticconi C. (Reprod Sci 2008)
    803. Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. (PubMed id 18205920)9 Xing B....Bing G. (J Neuroinflammation 2008)
    804. Suppression of inducible nitric oxide synthase expression and nitric oxide production by macrolide antibiotics in sulfur mustard-exposed airway epithelial cells. (PubMed id 18684233)9 Gao X....Ray P. (amp 2008)
    805. Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells. (PubMed id 19131704)9 Choi S.K....Chang H.I. (J. Microbiol. Biotechnol. 2008)
    806. Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade. (PubMed id 17031850)9 Vaillancourt F....Benderdour M. (J. Cell. Biochem. 2007)
    807. Inflammatory cytokines promote inducible nitric oxide synthase-mediated DNA damage in hamster gallbladder epithelial cells. (PubMed id 18081227)9 Kitasato A....Kanematsu T. (World J. Gastroenterol. 2007)
    808. [Study on the inhibition of vascular endothelial growth factor expression in Tca8113 cell by inducible nitric oxide synthase gene RNA interference]. (PubMed id 17462148)9 Zeng S.G....Zhang J.R. (Zhonghua Kou Qiang Yi Xue Za Zhi 2007)
    809. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. (PubMed id 17291856)9 Bergeron C....Hamid Q. (J. Allergy Clin. Immunol. 2007)
    810. Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants. (PubMed id 17920533)9 Chaea H.J....Chang K.C. (Int. Immunopharmacol. 2007)
    811. Ciprofloxacin inhibits cytokine-induced nitric oxide production in human colonic epithelium. (PubMed id 16968468)9 Kolios G....Kouroumalis E. (Eur. J. Clin. Invest. 2006)
    812. Quiescent interplay between inducible nitric oxide synthase and tumor necrosis factor-alpha: influence on transplant graft vasculopathy in renal allograft dysfunction. (PubMed id 16827641)9 Elahi M.M....Hakim N.S. (Exp Clin Transplant 2006)
    813. Comparative effects of azelnidipine and other Ca2+-channel blockers on the induction of inducible nitric oxide synthase in vascular smooth muscle cells. (PubMed id 16495772)9 Ma J....Nakajima T. (J. Cardiovasc. Pharmacol. 2006)
    814. Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. (PubMed id 16216410)9 Ohta T....Ochiai A. (Cancer Lett. 2006)
    815. Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. (PubMed id 16508403)9 CAclAcrier E....Puig M.M. (Anesthesiology 2006)
    816. Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma- and bacterial lipopolysaccharide-stimulated macrophages. (PubMed id 16166270)9 Zhou R....Zuo J.P. (J. Pharmacol. Exp. Ther. 2006)
    817. Pulmonary hypertension triggered by lipopolysaccharide in ascites-susceptible and -resistant broilers is not amplified by aminoguanidine, a specific inhibitor of inducible nitric oxide synthase. (PubMed id 16553285)9 Bowen O.T....Wideman R.F. (Poult. Sci. 2006)
    818. Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding. (PubMed id 16609073)9 Deng W.G....Wu K.K. (Blood 2006)
    819. The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer. (PubMed id 16580304)9 Malone J.M....Munkarah A.R. (Am. J. Obstet. Gynecol. 2006)
    820. Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells. (PubMed id 15683746)9 Chen T.H....Lee H.M. (Pharmacol. Res. 2005)
    821. Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease. (PubMed id 16041799)9 Okuno T....Sakoda S. (J. Neurosci. Res. 2005)
    822. Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea. (PubMed id 16154689)9 Morizane I....Gyo K. (Neurosci. Lett. 2005)
    823. Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy. (PubMed id 16099602)9 Chen H.H....Lee W.Y. (Int. J. Radiat. Oncol. Biol. Phys. 2005)
    824. Endotoxin-induced acute renal failure in rats: effects of L-arginine and nitric oxide synthase inhibition on renal function. (PubMed id 16245240)9 Schramm L....Wanner C. (J. Nephrol. 2005)
    825. [Expression of inductive nitric oxide synthase and vascular endothelial growth factor in colonic carcinoma, and their effects on tumor angiogenesis]. (PubMed id 16299654)9 Yin P....Liu Z.C. (Zhonghua Wei Chang Wai Ke Za Zhi 2005)
    826. [Nitric oxide and nitric oxide synthase in patients with chronic hepatitis B]. (PubMed id 16027781)9 Wang K....Wang H.M. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2005)
    827. The effects of nitric oxide in acute lung injury. (PubMed id 16256443)9 Mehta S. (Vascul. Pharmacol. 2005)
    828. [Expression of nitric oxide synthase and its significance in nasal polyps]. (PubMed id 15362679)9 Sun J....Liu R. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2004)
    829. Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia. (PubMed id 15104249)9 Chen C.J....Chen S.Y. (Biochem. Pharmacol. 2004)
    830. Biphasic induction of heme oxygenase-1 expression in macrophages stimulated with lipopolysaccharide. (PubMed id 15450936)9 Srisook K. and Cha Y.N. (Biochem. Pharmacol. 2004)
    831. Inducible nitric oxide synthase and vascular endothelial growth factor are colocalized in the retinas of human subjects with diabetes. (PubMed id 15004583)9 Abu El-Asrar A.M....Geboes K. (Eye (Lond) 2004)
    832. 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. (PubMed id 15036657)9 Oh G.S....Chung H.T. (Cancer Lett. 2004)
    833. Effects of C-peptide on expression of eNOS and iNOS in human cavernosal smooth muscle cells. (PubMed id 15351621)9 Li H....Sima A.A. (Urology 2004)
    834. [Expression of neuronal nitric oxide synthase and inducible nitric oxide synthase in the erector spinal muscles in idiopathic scoliosis]. (PubMed id 15379275)9 Zhao Y. and Qiu G.X. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004)
    835. Localization of inducible nitric oxide synthase and endothelial constitutive nitric oxide synthase in airway mucosa of toluene diisocyanate-induced asthma. (PubMed id 12974195)9 Lee S.K....Park C.S. (Allergy Asthma Proc 2003)
    836. Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells. (PubMed id 14599552)9 Shen L.J....Shen W.C. (Biochem. Pharmacol. 2003)
    837. Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone. (PubMed id 12594587)9 Tabernero A....Andriantsitohaina R. (Intensive Care Med 2003)
    838. Evidences for iNOS expression and nitric oxide production in the human macrophages. (PubMed id 12871028)9 Panaro M.A....Mitolo V. (Curr. Drug Targets Immune Endocr. Metabol. Disord. 2003)
    839. Role of nitric oxide in D-galactosamine-induced cell death and its protection by PGE1 in cultured hepatocytes. (PubMed id 12620377)9 Siendones E....MuntanAc J. (Nitric Oxide 2003)
    840. The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. (PubMed id 14566822)9 Park S.W....Sung M.W. (Int. J. Cancer 2003)
    841. Role of protein kinase C in BSA-AGE-mediated inducible nitric oxide synthase expression in RAW 264.7 macrophages. (PubMed id 12826263)9 Wu C.H....Lee H.M. (Biochem. Pharmacol. 2003)
    842. Salicylate suppresses macrophage nitric-oxide synthase-2 and cyclo-oxygenase-2 expression by inhibiting CCAAT/enhancer-binding protein-beta binding via a common signaling pathway. (PubMed id 12379662)9 Cieslik K....Wu K.K. (J. Biol. Chem. 2002)
    843. The role of inducible nitric oxide synthase in aseptic loosening after total hip arthroplasty. (PubMed id 12188499)9 Suh K.T....Jung J.S. (J Bone Joint Surg Br 2002)
    844. Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. (PubMed id 11910358)9 Resta-Lenert S. and Barrett K.E. (Gastroenterology 2002)
    845. Comparison of tumor necrosis factor-alpha effect on the expression of iNOS in macrophage and cardiac myocytes. (PubMed id 11192310)9 Sanders D.B....Yang B. (Perfusion 2001)
    846. The expression of cyclooxygenase 2 and inducible nitric oxide synthase indicates no active inflammation in vulvar vestibulitis. (PubMed id 11437722)9 Bohm-Starke N....Hilliges M. (Acta Obstet Gynecol Scand 2001)
    847. Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. (PubMed id 11532247)9 LA1th H.J....Arendt T. (Brain Res. 2001)
    848. Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli. (PubMed id 11396931)9 Zamora R....Billiar T.R. (Arch. Biochem. Biophys. 2001)
    849. Inhibitory effects of 17beta-estradiol and progesterone on ovarian carcinoma cell proliferation: a potential role for inducible nitric oxide synthase. (PubMed id 11426974)9 Keith Bechtel M. and Bonavida B. (Gynecol. Oncol. 2001)
    850. Nitric oxide and nitric oxide synthase in Huntington's disease. (PubMed id 11288139)9 Deckel A.W. (J. Neurosci. Res. 2001)
    851. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. (PubMed id 11331078)9 Chen Y.C....Yang L.L. (Biochem. Pharmacol. 2001)
    852. Inducible nitric oxide synthase expression before and after eradication of Helicobacter pylori in different forms of gastritis. (PubMed id 11267845)9 Antos D....Hatz R.A. (FEMS Immunol. Med. Microbiol. 2001)
    853. Current roles of nitric oxide in gastrointestinal disorders. (PubMed id 11595446)9 Cho C.H. (J. Physiol. Paris 2001)
    854. Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. (PubMed id 11312402)9 Redington A.E....Polak J.M. (Thorax 2001)
    855. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. (PubMed id 11506818)9 Surh Y.J....Lee S.S. (Mutat. Res. 2001)
    856. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. (PubMed id 10713108)9 Akama K.T. and Van Eldik L.J. (J. Biol. Chem. 2000)
    857. Time course of nitric oxide synthase generation after gluten exposure in the rectal mucosa of gluten-sensitive patients. (PubMed id 11145285)9 Niveloni S....Goldin E. (Scand. J. Gastroenterol. 2000)
    858. Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. (PubMed id 11156228)9 Marrogi A.J....Harris C.C. (Clin. Cancer Res. 2000)
    859. Physical exercise-induced expression of inducible nitric oxide synthase and heme oxygenase-1 in human leukocytes: effects of RRR-alpha-tocopherol supplementation. (PubMed id 11232592)9 Niess A.M....Fehrenbach E. (amp 2000)
    860. [Nitric oxide synthase and vascular endothelial growth factor expression in hepatocellular carcinoma and their relation to angiogenesis]. (PubMed id 11778555)9 Wang L....Sun H. (Zhonghua Zhong Liu Za Zhi 2000)
    861. Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. (PubMed id 10751555)9 Chen Y....Lee T.J. (Biochem. Pharmacol. 2000)
    862. Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase. (PubMed id 10839591)9 Barbaro G....Barbarini G. (AIDS 2000)
    863. Tumor necrosis factor-alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma cells. (PubMed id 11095498)9 Macdonald N.J. and Taglialatela G. (Neuroreport 2000)
    864. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages. (PubMed id 10900231)9 Jeon Y.J....Kim H.M. (J. Pharmacol. Exp. Ther. 2000)
    865. Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. (PubMed id 9931117)9 LaPointe M.C. and IsenoviA8 E. (Hypertension 1999)
    866. Human dermal microvascular endothelial cells express inducible nitric oxide synthase in vitro. (PubMed id 10084320)9 Hoffmann G....Sepp N. (J. Invest. Dermatol. 1999)
    867. Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. (PubMed id 10531359)9 Chen C.C....Chen W.C. (J. Biol. Chem. 1999)
    868. Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide. (PubMed id 10592110)9 Panaro M.A....Brandonisio O. (amp 1999)
    869. Nitric oxide levels in exhaled air and inducible nitric oxide synthase immunolocalization in pulmonary sarcoidosis. (PubMed id 10573228)9 Moodley Y.P....Lalloo U.G. (Eur. Respir. J. 1999)
    870. Lipid hydroperoxides inhibit nitric oxide production in RAW264.7 macrophages. (PubMed id 10218641)9 Huang A....Stone W.L. (amp 1999)
    871. Intensity of myocardial expression of inducible nitric oxide synthase influences the clinical course of human immunodeficiency virus-associated cardiomyopathy. Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS (GISCA). (PubMed id 10468523)9 Barbaro G....Barbarini G. (Circulation 1999)
    872. Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells. (PubMed id 10535759)9 Cheung F....O K. (Biochem. Pharmacol. 1999)
    873. Neutrophil accumulation and damage to the gastric mucosa in resuscitated hemorrhagic shock is independent of inducible nitric oxide synthase. (PubMed id 10353536)9 Tsukada K....Billiar T.R. (Shock 1999)
    874. Phospholipase A2 metabolites regulate inducible nitric oxide synthase in myocytes. (PubMed id 9453306)9 LaPointe M.C. and Sitkins J.R. (Hypertension 1998)
    875. Cloning and characterization of human inducible nitric oxide synthase splice variants: a domain, encoded by exons 8 and 9, is critical for dimerization. (PubMed id 9636200)9 Eissa N.T....Moss J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    876. Expression of inducible nitric oxide synthase and formation of peroxynitrite in posttransplant obliterative bronchiolitis. (PubMed id 9703237)9 Mason N.A....Polak J.M. (J. Heart Lung Transplant. 1998)
    877. Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis. (PubMed id 9607210)9 Furusu A....Kohno S. (Kidney Int. 1998)
    878. Inhibition on inducible nitric oxide synthase. (PubMed id 19649818)9 Rimoldi J.M. and Chimote S.S. (amp 1998)
    879. Nitric oxide synthase activity in human renal cell carcinoma. (PubMed id 9679928)9 Jansson O.T....Wiklund N.P. (J. Urol. 1998)
    880. Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer. (PubMed id 9716040)9 Liu C.Y....Kuo H.P. (Br. J. Cancer 1998)
    881. Expression of nitric oxide synthase isoforms in normal human tracheobronchial epithelial cells in vitro: dependence on retinoic acid and the state of differentiation. (PubMed id 9635256)9 Norford D....Nettesheim P. (Exp. Lung Res. 1998)
    882. Bacterial infection induces nitric oxide synthase in human neutrophils. (PubMed id 9011564)9 Wheeler M.A....Sessa W.C. (J. Clin. Invest. 1997)
    883. Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis. (PubMed id 9252518)9 Rockey D.C. and Chung J.J. (Am. J. Physiol. 1997)
    884. Bryostatin-1 and IFN-gamma synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages. (PubMed id 9192827)9 Taylor L.S....Espinoza-Delgado I. (Cancer Res. 1997)
    885. Immunolocalization of nitric oxide synthases at the postsynaptic domain of human and rat neuromuscular junctions--light and electron microscopic studies. (PubMed id 9398448)9 Yang C.C....Askanas V. (Exp. Neurol. 1997)
    886. Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorption. (PubMed id 9112415)9 Sunyer T....Collin-Osdoby P. (Endocrinology 1997)
    887. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. (PubMed id 9281609)9 Lin Y.L. and Lin J.K. (Mol. Pharmacol. 1997)
    888. [Study of nitric oxide synthases, nitric oxide and tumor necrosis factor in different types of ascites]. (PubMed id 9592341)9 Lu F....Huo J. (Zhonghua Nei Ke Za Zhi 1996)
    889. The role of nitric oxide in ethanol-induced gastrointestinal dysfunction. (PubMed id 8986213)9 Keshavarzian A....Fields J.Z. (Alcohol. Clin. Exp. Res. 1996)
    890. Structural diversity in the 5'-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA. (PubMed id 7537735)9 Chu S.C....Moss J. (J. Biol. Chem. 1995)
    891. Effect of asymmetric dimethyl arginine on nitric oxide synthase activity in normal and pre-eclamptic placentae. (PubMed id 8743168)9 King R.G....Brennecke S.P. (Reprod. Fertil. Dev. 1995)
    892. Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells. (PubMed id 7516158)9 Park S.K....Murphy S. (Biochem. Biophys. Res. Commun. 1994)
    893. Inducible nitric-oxide-synthase mRNA is transiently expressed and destroyed by a cycloheximide-sensitive process. (PubMed id 7508391)9 Evans T....Cohen J. (Eur. J. Biochem. 1994)
    894. Extremely low frequency electromagnetic fields modulate expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and cyclooxygenase-2 in the human keratinocyte cell line HaCat: potential therapeutic effects in wound healing. (PubMed id 19799606)9 Patruno A....Reale M. (Br. J. Dermatol. 2010)
    895. Inhibition of iNOS and COX-2 in human whole blood ex vivo and monocyte-macrophage J774 cells by a new group of aminothiopyrimidone derivatives. (PubMed id 19200742)9 Cardile V....Santagati A. (amp 2009)
    896. Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases. (PubMed id 19285099)9 Huang T.Y....Liao C.L. (Toxicol. Appl. Pharmacol. 2009)
    897. Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia. (PubMed id 19776611)9 Nishizawa H....Udagawa Y. (Gynecol. Obstet. Invest. 2009)
    898. Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma. (PubMed id 19165019)9 Chen W.L....Wang J.G. (J Craniofac Surg 2009)
    899. Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model. (PubMed id 18502427)9 Xiong W....Johanning J. (Atherosclerosis 2009)
    900. iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells. (PubMed id 19925669)9 De Boo S....Riganti C. (Mol. Cancer 2009)
    901. Cellular ADMA: regulation and action. (PubMed id 19682580)9 Teerlink T....Wilcox C.S. (Pharmacol. Res. 2009)
    902. Influence of progesterone on endometrial nitric oxide synthase expression. (PubMed id 18710710)9 Khorram O. and Han G. (Fertil. Steril. 2009)
    903. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. (PubMed id 18325727)9 Kim K.M....Chung H.T. (amp 2008)
    904. The effect of pioglitazone on nitric oxide synthase in patients with type 2 diabetes mellitus. (PubMed id 19040587)9 Nishio K....Kobayashi Y. (J Cardiometab Syndr 2008)
    905. TGF beta 1 and TNF alpha potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2. (PubMed id 18035449)9 Hamby M.E....Hewett J.A. (Neurochem. Int. 2008)
    906. The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. (PubMed id 17997414)9 Xie X.Q....Hojo N. (J. Surg. Res. 2008)
    907. Effect of sildenafil citrate on interleukin-1beta-induced nitric oxide synthesis and iNOS expression in SW982 cells. (PubMed id 18587266)9 Kim K.O....Han J.S. (amp 2008)
    908. Smooth muscle cells, dendritic cells and mast cells are sources of TNFalpha and nitric oxide in human carotid artery atherosclerosis. (PubMed id 18561985)9 Bacci S....Romagnoli P. (Thromb. Res. 2008)
    909. Inducible nitric oxide synthase expressions in different lung injury models and the protective effect of aminoguanidine. (PubMed id 18790185)9 Yeh D.Y....Wang D. (Transplant. Proc. 2008)
    910. Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. (PubMed id 18559542)9 Mallery S.R....Stoner G.D. (Cancer Res. 2008)
    911. Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. (PubMed id 18644994)9 Chittezhath M....Agarwal R. (Mol. Cancer Ther. 2008)
    912. Inducible nitric oxide synthase (iNOS): role in asthma pathogenesis. (PubMed id 18341205)9 Batra J....Ghosh B. (amp 2007)
    913. Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. (PubMed id 17513437)9 Mori M. (J. Nutr. 2007)
    914. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. (PubMed id 17184768)9 GarcA-a-Mediavilla V....GonzA!lez-Gallego J. (Eur. J. Pharmacol. 2007)
    915. Inducible nitric oxide synthase mediates hypoxia-induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen-induced retinopathy. (PubMed id 18087198)9 He T....Xing Y.Q. (Pathobiology 2007)
    916. Expression of HIF-1alpha and iNOS in astrocytic gliomas: a clinicopathological study. (PubMed id 16724682)9 Giannopoulou E....Kardamakis D. (In Vivo 2006)
    917. Up-regulation of hypoxia inducible factor 1alpha by isoflurane in Hep3B cells. (PubMed id 17122584)9 Li Q.F....Su D.S. (Anesthesiology 2006)
    918. Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. (PubMed id 16801455)9 Topal G....David-Dufilho M. (J. Pharmacol. Exp. Ther. 2006)
    919. IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways. (PubMed id 16881054)9 Kim Y.J....Han I.O. (J. Neurosci. Res. 2006)
    920. Anti-inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via the NF-kappaB inactivation. (PubMed id 16520738)9 Won J.H....Lee K.T. (Br. J. Pharmacol. 2006)
    921. Nitric oxide synthases are associated with bronchial dysplasia. (PubMed id 16420964)9 Puhakka A.R....Kinnula V.L. (Lung Cancer 2006)
    922. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. (PubMed id 16000635)9 Martin L.J....Liu Z. (J. Neurosci. 2005)
    923. Hypoxia-induced expression of HIF-1alpha and its target genes in umbilical venous endothelial cells of Tibetans and immigrant Han. (PubMed id 15970466)9 Gao W....Shi J. (amp 2005)
    924. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages by sesquiterpene lactones. (PubMed id 16326428)9 Shin S.G....Choi W.S. (J. Toxicol. Environ. Health Part A 2005)
    925. A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. (PubMed id 15855318)9 Fujimoto M....Kaneki M. (Diabetes 2005)
    926. Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. (PubMed id 15647265)9 Connelly L....Hobbs A.J. (J. Biol. Chem. 2005)
    927. Expression of inducible nitric oxide synthase and effects of L-arginine on colonic nitric oxide production and fluid transport in patients with &quot;minimal colitis&quot;. (PubMed id 16165717)9 Perner A....Rask-Madsen J. (Scand. J. Gastroenterol. 2005)
    928. LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase. (PubMed id 15894110)9 Kim Y.H....Kwon T.K. (Immunol. Lett. 2005)
    929. Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. (PubMed id 15020063)9 Rose J.W....Carlson N.G. (J. Neuroimmunol. 2004)
    930. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. (PubMed id 15165031)9 Franco L....Bassi C. (amp 2004)
    931. Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction. (PubMed id 15325021)9 McCarty M.F. (Med. Hypotheses 2004)
    932. Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. (PubMed id 15088099)9 Hara A. and Okayasu I. (Acta Neuropathol. 2004)
    933. Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. (PubMed id 15023380)9 Dumond H....Jouzeau J.Y. (Osteoarthr. Cartil. 2004)
    934. Protective effect of pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, on ischemia-induced neuronal damage. (PubMed id 15327760)9 Kurosaki R....Araki T. (Neurol. Res. 2004)
    935. Expression of endothelial and inducible nitric oxide synthases is modulated in the endometrium of cyclic and early pregnant mares. (PubMed id 15740692)9 Welter H....Einspanier R. (Reprod. Fertil. Dev. 2004)
    936. Inflammatory mediators in autoimmune lacrimal gland disease in MRL/Mpj mice. (PubMed id 15223808)9 Jabs D.A....Whittum-Hudson J.A. (amp 2004)
    937. Aerosolized gamma interferon (IFN-gamma) induces expression of the genes encoding the IFN-gamma-inducible 10-kilodalton protein but not inducible nitric oxide synthase in the lung during tuberculosis. (PubMed id 14977928)9 Raju B....Weiden M.D. (Infect. Immun. 2004)
    938. High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. (PubMed id 15569052)9 Ichinoe M....Okayasu I. (Histopathology 2004)
    939. Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment: a cross-sectional study. (PubMed id 15673150)9 D'Attillio M....Perinetti G. (Angle Orthod 2004)
    940. [Expression and significance of nitric oxide synthase mRNAs and proteins in giant cell tumors of bone]. (PubMed id 14613648)9 Li H.G....Dong S.K. (Ai Zheng 2003)
    941. High expression of nitric oxide synthases is a favorable prognostic sign in non-small cell lung carcinoma. (PubMed id 14678024)9 Puhakka A....Soini Y. (APMIS 2003)
    942. [Influence of beta-endorphin on function of immune system of patients with cerebral hemorrhage]. (PubMed id 14521744)9 Jin X....Gao Y. (Zhonghua Yi Xue Za Zhi 2003)
    943. IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells. (PubMed id 12592345)9 Levesque M.C....Weinberg J.B. (Leukemia 2003)
    944. [Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts]. (PubMed id 12621554)9 Yao H.P....Zhang L.H. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003)
    945. Endothelial nitric oxide synthase (NOS) is upregulated in rapid progressive pulmonary hypertension of the newborn. (PubMed id 12904860)9 Hoehn T....Wadsworth R.M. (Intensive Care Med 2003)
    946. Estrogen increases inducible nitric oxide synthase gene expression. (PubMed id 12748480)9 Walsh L.S....Mershon J.L. (Am. J. Obstet. Gynecol. 2003)
    947. Expression of nitric oxide synthases in keratinocytes after UVB irradiation. (PubMed id 14615895)9 Chang H.R....Yu H.S. (Arch. Dermatol. Res. 2003)
    948. Up-regulation of inducible nitric oxide synthase in Helicobacter pylori-associated gastritis may represent an increased risk factor to develop gastric carcinoma of the intestinal type. (PubMed id 14760971)9 Rieder G....Enders G.A. (Int. J. Med. Microbiol. 2003)
    949. Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. (PubMed id 12637371)9 Salloum F....Kukreja R.C. (Circ. Res. 2003)
    950. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. (PubMed id 12507903)9 Bruch-Gerharz D....Kolb-Bachofen V. (Am. J. Pathol. 2003)
    951. Involvement of oxidative and nitrosative stress in promoting retinal vasculitis in patients with Eales' disease. (PubMed id 12849870)9 Rajesh M....Ramakrishnan S. (Clin. Biochem. 2003)
    952. Association of elevated glial expression of interleukin-1beta with improved survival in patients with glioblastomas multiforme. (PubMed id 11838804)9 Cuny E....Demotes-Mainard J. (J. Neurosurg. 2002)
    953. Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. (PubMed id 11939728)9 Nose F....Okayasu I. (Am. J. Clin. Pathol. 2002)
    954. Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. (PubMed id 11825662)9 Sasahara Y....Wakabayashi K. (Cancer Lett. 2002)
    955. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. (PubMed id 11788351)9 Cooke C.L. and Davidge S.T. (Am. J. Physiol., Cell Physiol. 2002)
    956. N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship. (PubMed id 11831907)9 Renodon-CorniA"re A....Mansuy D. (J. Med. Chem. 2002)
    957. Estrogen increases iNOS expression in the ovine coronary artery. (PubMed id 12181148)9 Mershon J.L....Clark K.E. (Am. J. Physiol. Heart Circ. Physiol. 2002)
    958. Expression of type 2 nitric oxide synthase and vascular endothelial growth factor in oral dysplasia. (PubMed id 12465010)9 Brennan P.A....Mellor T.K. (J. Oral Maxillofac. Surg. 2002)
    959. [The arginine paradox]. (PubMed id 11862757)9 Nakaki T. and Hishikawa K. (Nippon Yakurigaku Zasshi 2002)
    960. Altered mRNA expression of ecNOS and iNOS in myometrium and placenta from women with preeclampsia. (PubMed id 11327094)9 FaxAcn M....Kublickiene K.R. (Arch. Gynecol. Obstet. 2001)
    961. Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia. (PubMed id 11166745)9 Shaamash A.H....El-Dien H.M. (Int J Gynaecol Obstet 2001)
    962. Posttranscriptional regulation of human iNOS by the NO/cGMP pathway. (PubMed id 11181408)9 PAcrez-Sala D....Lamas S. (Am. J. Physiol. Renal Physiol. 2001)
    963. Nitric oxide synthase immunoreactivity in human bladder carcinoma. (PubMed id 11477140)9 Shochina M....Ariel I. (MP, Mol. Pathol. 2001)
    964. Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. (PubMed id 11310211)9 Uotila P....HAorkAPnen P. (Urol. Res. 2001)
    965. [A quantitative pathological study on angiogenesis, vascular endothelial growth factor and inducible nitric oxide synthase in astrocytomas]. (PubMed id 11866952)9 Bian X....Liu F. (Zhonghua Bing Li Xue Za Zhi 2001)
    966. Oxygen tension limits nitric oxide synthesis by activated macrophages. (PubMed id 10970783)9 McCormick C.C....Calero M. (Biochem. J. 2000)
    967. Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas. (PubMed id 10873093)9 Vakkala M....Soini Y. (Clin. Cancer Res. 2000)
    968. Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP. (PubMed id 10802528)9 Millatt L.J....Whitley G.S. (Eur. J. Endocrinol. 2000)
    969. Expression and relationship between endothelin-1 messenger ribonucleic acid (mRNA) and inducible/endothelial nitric oxide synthase mRNA isoforms from normal and preeclamptic placentas. (PubMed id 10852470)9 Napolitano M....Lanzone A. (J. Clin. Endocrinol. Metab. 2000)
    970. Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. (PubMed id 10874135)9 Fukuda K....Fujiwara H. (Biochem. Pharmacol. 2000)
    971. Expression of inducible nitric oxide synthase in healthy pleura and in malignant mesothelioma. (PubMed id 10970689)9 Soini Y....Kinnula V. (Br. J. Cancer 2000)
    972. Effects of XW630 on cell proliferation, iNOS activity, and cGMP content in human osteoblast-like cell line TE85. (PubMed id 11324428)9 Sun L....Liu J.S. (Acta Pharmacol. Sin. 2000)
    973. Site-specific lesion formation, inflammation and inducible nitric oxide synthase expression by indomethacin in the rat intestine. (PubMed id 10675738)9 Evans S.M....Whittle B.J. (Eur. J. Pharmacol. 2000)
    974. Variants of NOS1, NOS2, and NOS3 genes in asthmatics. (PubMed id 10673365)9 Gao P.S....Hopkin J.M. (Biochem. Biophys. Res. Commun. 2000)
    975. Nitric oxide sensitizes ovarian tumor cells to Fas-induced apoptosis. (PubMed id 10329044)9 GarbA!n H.J. and Bonavida B. (Gynecol. Oncol. 1999)
    976. Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma. (PubMed id 10188914)9 Tschugguel W....Pehamberger H. (Br. J. Cancer 1999)
    977. The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages. (PubMed id 10588517)9 Baek S.H....Kwun K.B. (Shock 1999)
    978. Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages. (PubMed id 10405759)9 Paul A....Plevin R. (Cell. Signal. 1999)
    979. Frequent expression of inducible nitric oxide synthase in esophageal squamous cell carcinomas. (PubMed id 10339659)9 Tanaka H....Makuuchi H. (Int. J. Oncol. 1999)
    980. Downregulation of endothelin-1 by interleukin-4 during gastric ulcer healing. (PubMed id 10491337)9 Slomiany B.L....Slomiany A. (Biochem. Biophys. Res. Commun. 1999)
    981. Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyp epithelium. (PubMed id 9515595)9 Watkins D.N....Thompson P.J. (Clin. Exp. Allergy 1998)
    982. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). (PubMed id 9837777)9 Kroll J. and Waltenberger J. (Biochem. Biophys. Res. Commun. 1998)
    983. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis. (PubMed id 9870873)9 Melchiorri C....Facchini A. (Arthritis Rheum. 1998)
    984. Differential expression of nitric oxide synthase isoforms in form-deprived chick eyes. (PubMed id 9663848)9 Fujii S....Saijoh K. (Curr. Eye Res. 1998)
    985. N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases. (PubMed id 9313865)9 Fast W....Silverman R.B. (amp 1997)
    986. Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes. (PubMed id 9065701)9 Shimizu Y....Ueda H. (J. Dermatol. 1997)
    987. An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. (PubMed id 9368047)9 Salerno J.C....Gross S.S. (J. Biol. Chem. 1997)
    988. Molecular pathology of cerebral ischemia: delayed gene expression and strategies for neuroprotection. (PubMed id 9616775)9 Iadecola C. and Ross M.E. (Ann. N. Y. Acad. Sci. 1997)
    989. Myocardial contractile effects of L-arginine in the human allograft. (PubMed id 9137232)9 Paulus W.J....Drexler H. (J. Am. Coll. Cardiol. 1997)
    990. Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains. (PubMed id 8631749)9 Siddhanta U....Stuehr D.J. (J. Biol. Chem. 1996)
    991. Removal of constitutive and inducible nitric oxide synthase-active compounds in a modified hemodiafiltration with on-line production of substitution fluid: the contribution of convection and diffusion. (PubMed id 9029246)9 Arese M....Canaud B. (Int J Artif Organs 1996)
    992. Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. (PubMed id 8700134)9 Duval D.L....Billings R.E. (Mol. Pharmacol. 1996)
    993. Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. (PubMed id 7559438)9 Abu-Soud H.M....Stuehr D.J. (J. Biol. Chem. 1995)
    994. Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. (PubMed id 7664438)9 Mehta S....Levy R.D. (Circulation 1995)
    995. Nitric oxide activates cyclooxygenase enzymes. (PubMed id 7688473)9 Salvemini D....Needleman P. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    996. Autoantibodies from schizophrenia patients induce cerebral cox-1/iNOS mRNA expression with NO/PGE2/MMP-3 production. (PubMed id 19835666)9 Ganzinelli S....Sterin-Borda L. (Int. J. Neuropsychopharmacol. 2010)
    997. Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. (PubMed id 20008515)9 DeNiro M....Al-Mohanna F.A. (Mol. Pharmacol. 2010)
    998. IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia. (PubMed id 20468050)9 Baker B.J....Benveniste E.N. (Glia 2010)
    999. Development of nitrergic neurons in the nervous system of the locust embryo. (PubMed id 20148434)9 Stern M....Bicker G. (J. Comp. Neurol. 2010)
    1000. Integrin-linked kinase is involved in TNF-alpha-induced inducible nitric-oxide synthase expression in myoblasts. (PubMed id 20135642)9 Tsou H.K....Chen Y.H. (J. Cell. Biochem. 2010)
    1001. Induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide. (PubMed id 19629394)9 Pullen N.A. and Fillmore H.L. (J. Neurooncol. 2010)
    1002. Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing. (PubMed id 20338478)9 Jiang H....Storme G.A. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    1003. Human skin-derived mesenchymal stem cells as a source of VEGF and nitric oxide. (PubMed id 20035428)9 Salvolini E....Di Primio R. (Arch. Dermatol. Res. 2010)
    1004. 3-Nitrotyrosine inhibits fibroblast-mediated collagen gel contraction and chemotaxis. (PubMed id 19443526)9 Sugiura H....Rennard S.I. (Eur. Respir. J. 2009)
    1005. Significant negative correlations between capillary expressed eNOS and Alzheimer lesion burden. (PubMed id 19660523)9 Jeynes B. and Provias J. (Neurosci. Lett. 2009)
    1006. Placental gene expression of calcitonin gene-related peptide and nitric oxide synthases in preeclampsia: effects of magnesium sulfate. (PubMed id 19441274)9 Ariza A.C....Halhali A. (Magnes Res 2009)
    1007. Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat. (PubMed id 19122291)9 Nagai N....Hirano K. (amp 2009)
    1008. Re and (99m)Tc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase. (PubMed id 19081984)9 Oliveira B.L....Freire A.P. (Dalton Trans 2009)
    1009. Phytochemicals from Flemingia vestita (Fabaceae) and Stephania glabra (Menispermeaceae) alter cGMP concentration in the cestode Raillietina echinobothrida. (PubMed id 18854226)9 Das B....Ferro V.A. (amp 2009)
    1010. Nitric oxide synthase gene therapy: progress and prospects. (PubMed id 19463074)9 O'Connor D.M. and O'Brien T. (Expert Opin Biol Ther 2009)
    1011. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. (PubMed id 19286931)9 North M.L....Scott J.A. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    1012. The protective effects of green tea extract against L-arginine toxicity to cultured human mesangial cells. (PubMed id 19194554)9 Shin B.C....Kim H.L. (J. Korean Med. Sci. 2009)
    1013. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. (PubMed id 19699788)9 Kim E.H....Chun M. (J Ethnopharmacol 2009)
    1014. Basal nitric oxide synthase activity is a major determinant of glomerular haemodynamics in humans. (PubMed id 18090547)9 Schlaich M.P....Schmieder R.E. (J. Hypertens. 2008)
    1015. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. (PubMed id 18559982)9 Stadler K....Kadiiska M.B. (Am. J. Physiol. Endocrinol. Metab. 2008)
    1016. Nitroglycerin enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via nitric oxide pathway. (PubMed id 18430366)9 Huang L....Xiao Z.S. (Acta Pharmacol. Sin. 2008)
    1017. Induction of nitric oxide synthases in primary human cultured mast cells by IgE and proinflammatory cytokines. (PubMed id 18387520)9 Yip K.H....Lau H.Y. (Int. Immunopharmacol. 2008)
    1018. Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats. (PubMed id 17882231)9 Kovanecz I....Gonzalez-Cadavid N. (Int. J. Impot. Res. 2008)
    1019. Intracerebroventricular injection of L-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks. (PubMed id 18163184)9 Suenaga R....Furuse M. (Amino Acids 2008)
    1020. Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia. (PubMed id 17298834)9 Ott C....Schmieder R.E. (Atherosclerosis 2008)
    1021. Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine. (PubMed id 18342305)9 Feng M....Xiong Y. (Eur. J. Pharmacol. 2008)
    1022. Analysis of NO-synthase expression and clinical risk factors in human diabetic nephropathy. (PubMed id 18065828)9 Hohenstein B....Schmieder R.E. (Nephrol. Dial. Transplant. 2008)
    1023. APOBEC and iNOS are not the main intracellular effectors of IFN-gamma-mediated inactivation of Hepatitis B virus replication. (PubMed id 18313151)9 Proto S....Naoumov N.V. (Antiviral Res. 2008)
    1024. Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOS-mediated neurotoxicity in a coculture of neurons and microglia. (PubMed id 18627024)9 Yu H.H....Shen L.J. (J. Neurosci. Res. 2008)
    1025. Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer. (PubMed id 18503779)9 Yasuda H. (Nitric Oxide 2008)
    1026. Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-kappaB inactivation. (PubMed id 18841975)9 Yun K.J....Lee K.T. (J. Agric. Food Chem. 2008)
    1027. NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions. (PubMed id 18441394)9 Czesnikiewicz-Guzik M....Korbut R. (J. Physiol. Pharmacol. 2008)
    1028. Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. (PubMed id 18348730)9 Chowdhury T.T....Lee D.A. (amp 2008)
    1029. Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase. (PubMed id 17615555)9 Kuo C.L....Lin W.W. (J. Cell. Biochem. 2008)
    1030. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III). (PubMed id 18325637)9 CarriA^n M.D....Entrena A. (Eur J Med Chem 2008)
    1031. Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. (PubMed id 18347075)9 Osorio Y....Travi B.L. (J. Leukoc. Biol. 2008)
    1032. Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. (PubMed id 18528866)9 Rotondo R....Frumento G. (Int. J. Cancer 2008)
    1033. [Endothelial and inducible nitric oxide synthase expression in Venezuelan patients with pre-eclampsia]. (PubMed id 18846773)9 AlemA!n I....RamA-rez C. (Invest Clin 2008)
    1034. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. (PubMed id 17592514)9 Esposito G....Steardo L. (Br. J. Pharmacol. 2007)
    1035. Opioids induce renal abnormalities in tumor-bearing mice. (PubMed id 17220637)9 Arerangaiah R....Gupta K. (Nephron Exp. Nephrol. 2007)
    1036. A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. (PubMed id 17684157)9 Chabannes D....Cuturi M.C. (Blood 2007)
    1037. Sustained activation of nuclear factor-kappaB by reactive oxygen species is involved in the pathogenesis of stress-induced gastric damage in rats. (PubMed id 17452936)9 Jia Y.T....Xia Z.F. (Crit. Care Med. 2007)
    1038. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. (PubMed id 17717202)9 Singh D....O'Connor B.J. (Am. J. Respir. Crit. Care Med. 2007)
    1039. Murine pre-eclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta. (PubMed id 17129602)9 Schmid M....Zenclussen A.C. (Placenta 2007)
    1040. Irradiation at 634 nm releases nitric oxide from human monocytes. (PubMed id 17120165)9 LindgAYrd A....Soussi B. (Lasers Med Sci 2007)
    1041. The enzymatic machinery for ADMA synthesis and degradation is fully expressed in human adipocytes. (PubMed id 17918140)9 Spoto B....Zoccali C. (J. Nephrol. 2007)
    1042. Focused antibody response in plasma cell-infiltrated non-medullary (NOS) breast cancers. (PubMed id 17393302)9 Wang Y....Junghans R.P. (Breast Cancer Res. Treat. 2007)
    1043. Anti-brain cholinergic auto antibodies from primary SjAPgren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis. (PubMed id 17920530)9 Orman B....Borda E. (Int. Immunopharmacol. 2007)
    1044. Attenuation of experimental subarachnoid hemorrhage--induced cerebral vasospasm by the adenosine A2A receptor agonist CGS 21680. (PubMed id 17367066)9 Lin C.L....Kwan A.L. (J. Neurosurg. 2007)
    1045. Influence of estrogen cycle on temporomandibular joint synovial membrane in rat with deviated mandible. (PubMed id 19845139)9 Kishimoto G....Soma K. (J. Med. Dent. Sci. 2007)
    1046. NOS evaluations in human dental pulp-capping with MTA and calcium-hydroxide. (PubMed id 17897498)9 D'Arcangelo C....Caputi S. (Int J Immunopathol Pharmacol 2007)
    1047. Role of nitric oxide and reactive oxygen species in arthritis. (PubMed id 17017948)9 Cuzzocrea S. (Curr. Pharm. Des. 2006)
    1048. Green tea polyphenol epigallocatechin-3-gallate inhibits the expression of nitric oxide synthase and generation of nitric oxide induced by ultraviolet B in HaCaT cells. (PubMed id 16537022)9 Song X.Z....Xu A.E. (Chin. Med. J. 2006)
    1049. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. (PubMed id 16427328)9 Whiteman M....Schantz J.T. (Osteoarthr. Cartil. 2006)
    1050. Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. (PubMed id 16685418)9 Kim Y.A....Choi Y.H. (Int. J. Mol. Med. 2006)
    1051. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. (PubMed id 16806998)9 Wang C.T....Hou S.M. (Osteoarthr. Cartil. 2006)
    1052. Adenoviral-mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation. (PubMed id 16921253)9 Cooney R....O'Brien T. (J. Vasc. Res. 2006)
    1053. Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages. (PubMed id 16421203)9 Weber T.J....Thrall B.D. (Am. J. Physiol., Cell Physiol. 2006)
    1054. [Highly selective inhibition of inducible nitric oxide synthase in vitro by a tripeptide as a new arginine analog]. (PubMed id 17062343)9 Sun F....Liu C.Q. (Nan Fang Yi Ke Da Xue Xue Bao 2006)
    1055. [Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical]. (PubMed id 17205823)9 Li J.X....Deng Z.H. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2006)
    1056. Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease. (PubMed id 17137520)9 Zhu F. and Qian C. (BMC Neurosci 2006)
    1057. Interrelated overexpression of endothelial and inducible nitric oxide synthases, endothelin-1 and angiogenic factors in human papillary thyroid carcinoma. (PubMed id 16712675)9 Donckier J.E....Van Beneden R. (Clin. Endocrinol. (Oxf) 2006)
    1058. Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice. (PubMed id 16941682)9 GarcA-a-Ruiz I....SolA-s-Herruzo J.A. (Hepatology 2006)
    1059. The peritoneal cavity is a distinct compartment of angiogenic molecular mediators. (PubMed id 16650862)9 Nachtsheim R....Howdieshell T.R. (J. Surg. Res. 2006)
    1060. Hydrogen peroxide acts as relaxing factor in human vascular smooth muscle cells independent of map-kinase and nitric oxide. (PubMed id 16720330)9 Palen D.I....Matrougui K. (Front. Biosci. 2006)
    1061. Reperfusion liver injury induces down-regulation of eNOS and up-regulation of iNOS in lung tissues. (PubMed id 16980043)9 Lin H.I....Chen C.F. (Transplant. Proc. 2006)
    1062. The role of Rho-associated kinase in differential regulation by statins of interleukin-1beta- and lipopolysaccharide-mediated nuclear factor kappaB activation and inducible nitric-oxide synthase gene expression in vascular smooth muscle cells. (PubMed id 16317111)9 Wei C.Y....Lin W.W. (Mol. Pharmacol. 2006)
    1063. Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review. (PubMed id 15993340)9 Willmot M....Bath P. (amp 2005)
    1064. Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. (PubMed id 15721623)9 Espinosa-Heidmann D.G....Cousins S.W. (Exp. Eye Res. 2005)
    1065. Catecholamines' enhancement of inducible nitric oxide synthase-induced nitric oxide biosynthesis involves CAT-1 and CAT-2A. (PubMed id 15976236)9 Lin W.C....Huang C.J. (Anesth. Analg. 2005)
    1066. Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells. (PubMed id 16144552)9 Thomas M.S....Taglialatela G. (J Neuroinflammation 2005)
    1067. Nitric oxide paradox in asthma. (PubMed id 15962094)9 Keller A.C....Russo M. (Mem. Inst. Oswaldo Cruz 2005)
    1068. Inducible nitric oxide synthase links NF-kappaB to PGE2 in polyunsaturated fatty acid altered fibroblast in-vitro wound healing. (PubMed id 16011805)9 Jia Y. and Turek J.J. (Lipids Health Dis 2005)
    1069. Beta-adrenergic receptor activation in immortalized human urothelial cells stimulates inflammatory responses by PKA-independent mechanisms. (PubMed id 16091148)9 Harmon E.B....Porter J.E. (Cell Commun. Signal 2005)
    1070. Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS. (PubMed id 15715934)9 Li D.X....Wu C.F. (Acta Pharmacol. Sin. 2005)
    1071. Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. (PubMed id 15723947)9 Soo R....Hsieh W.S. (amp 2005)
    1072. Regulation of nitric oxide synthase isoforms by estrogen in the human endometrium. (PubMed id 16210014)9 Han G....Khorram O. (Fertil. Steril. 2005)
    1073. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. (PubMed id 15778742)9 Alderton W.K....Knowles R.G. (Br. J. Pharmacol. 2005)
    1074. Steroid cell tumors, not otherwise specified (NOS), in an accessory ovary: a case report and literature review. (PubMed id 15790472)9 Liu A.X....Song W.Q. (Gynecol. Oncol. 2005)
    1075. Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages. (PubMed id 15316927)9 Lin H.Y....Chen Y.C. (J. Cell. Physiol. 2005)
    1076. The effect of intravesical Bacillus Calmette-Guerin instillations on the expression of inducible nitric oxide synthase in humans. (PubMed id 15964223)9 Mitropoulos D....Dimopoulos C. (Nitric Oxide 2005)
    1077. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia. (PubMed id 16174294)9 Ayasolla K.R....Singh I. (J Neuroinflammation 2005)
    1078. Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis. (PubMed id 15753535)9 Andresen L....Rask-Madsen J. (Gut 2005)
    1079. Differential induction of TNF-alpha and NOS2 by mitogen-activated protein kinase signaling pathways during Mycobacterium bovis infection. (PubMed id 14667793)9 MAcndez-Samperio P....RamA-rez F.A. (J. Infect. 2004)
    1080. Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. (PubMed id 15520210)9 Cook T....Blumberg D. (Cancer Res. 2004)
    1081. Expression of inducible nitric oxide synthase is increased in patients with heart failure due to ischemic disease. (PubMed id 15334196)9 Ferreiro C.R....da Luz P.L. (Braz. J. Med. Biol. Res. 2004)
    1082. NOS isoforms in adult human osteocytes: multiple pathways of NO regulation? (PubMed id 15148557)9 Caballero-AlA-as A.M....Reeve J. (Calcif. Tissue Int. 2004)
    1083. Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production. (PubMed id 15490111)9 Erdely A....Baylis C. (Diabetologia 2004)
    1084. Interferon-gamma cooperates with Helicobacter pylori to induce iNOS-related apoptosis in AGS gastric adenocarcinoma cells. (PubMed id 15142623)9 Perfetto B....Donnarumma G. (Res. Microbiol. 2004)
    1085. Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase. (PubMed id 15051034)9 Wang X....Trudinger B. (J. Soc. Gynecol. Investig. 2004)
    1086. [Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts]. (PubMed id 15067740)9 Shao X.T....Zhang L.H. (Zhejiang Da Xue Xue Bao Yi Xue Ban 2004)
    1087. Arginine metabolic enzymes, nitric oxide and infection. (PubMed id 15465793)9 Mori M. and Gotoh T. (J. Nutr. 2004)
    1088. Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection. (PubMed id 15504246)9 Matsubara S....Wakabayashi K. (Cancer Sci. 2004)
    1089. Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation. (PubMed id 15016631)9 Smirnova I.V....Goligorsky M.S. (Am. J. Physiol. Heart Circ. Physiol. 2004)
    1090. Acetylbritannilatone suppresses NO and PGE2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression. (PubMed id 15172177)9 Han M....Zhang D.Q. (Life Sci. 2004)
    1091. Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. (PubMed id 15179184)9 Zheng M....Grimm E.A. (Melanoma Res. 2004)
    1092. Nitric oxide synthase inhibition: therapeutic potential in asthma. (PubMed id 15182209)9 Mulrennan S.A. and Redington A.E. (Treat Respir Med 2004)
    1093. Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. (PubMed id 15693609)9 Murthy K.G....Salzman A.L. (Inflamm. Res. 2004)
    1094. Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes. (PubMed id 15030977)9 Teshima S....Okumura T. (J. Hepatol. 2004)
    1095. Antioxidative response for nitric oxide production in breast carcinoma. (PubMed id 15375496)9 Karihtala P....Soini Y. (Oncol. Rep. 2004)
    1096. [Expression related to vascular endothelial growth factor C and induced nitride oxide synthesizase in lymph node micrometastasis of oral squamous cell carcinoma]. (PubMed id 15656516)9 Xie Z.J....Zhang Y.K. (Hua Xi Kou Qiang Yi Xue Za Zhi 2004)
    1097. Production of arginine by the kidney is impaired in a model of sepsis: early events following LPS. (PubMed id 15308488)9 Lortie M.J....Munger K.A. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004)
    1098. Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase. (PubMed id 15380928)9 Jimenez-Feltstrom J....Salehi A. (Regul. Pept. 2004)
    1099. L-arginine promotes capacitation and acrosome reaction in cryopreserved bovine spermatozoa. (PubMed id 15374626)9 O'Flaherty C....Srivastava S. (Biochim. Biophys. Acta 2004)
    1100. Mechanisms underlying growth hormone effects in augmenting nitric oxide production and protein tyrosine nitration during endotoxin challenge. (PubMed id 15044352)9 Elsasser T.H....Li C. (Endocrinology 2004)
    1101. Dual effects of caspase-1, interleukin-1 beta, tumour necrosis factor-alpha and nerve growth factor receptor in inflammatory myopathies. (PubMed id 12673888)9 Mackiewicz Z....Konttinen Y.T. (Clin. Exp. Rheumatol. 2003)
    1102. [Expression of nuclear factor-kappa B mRNA, inducible nitric oxide synthase and interleukin-6 in nasal polyp and its role]. (PubMed id 15040111)9 Zhang H....Ma X.D. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2003)
    1103. Inducible nitric oxide synthase-mediated proliferation of a T lymphoma cell line. (PubMed id 12620374)9 Barreiro Arcos M.L....Cremaschi G.A. (Nitric Oxide 2003)
    1104. AQP1 and AQP3, psoriasin, and nitric oxide synthases 1-3 are inflammatory mediators in erythema toxicum neonatorum. (PubMed id 14521551)9 Marchini G....Nielsen S. (Pediatr Dermatol 2003)
    1105. Nuclear factor-kappa B activation in skeletal muscle of patients with chronic heart failure: correlation with the expression of inducible nitric oxide synthase. (PubMed id 14555882)9 Adams V....Hambrecht R. (amp 2003)
    1106. [Effect of magnesium supplementation on NO and NOS subtypes in cultured human umbilical vein endothelial Cells]. (PubMed id 15600206)9 LA1 X. and Ruishu W. (Sichuan Da Xue Xue Bao Yi Xue Ban 2003)
    1107. L-arginine metabolism in myeloid cells controls T-lymphocyte functions. (PubMed id 12810105)9 Bronte V....Zanovello P. (Trends Immunol. 2003)
    1108. Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy. (PubMed id 12485814)9 Bronzwaer J.G....Paulus W.J. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    1109. Expression of inducible nitric oxide synthase in bone metastases. (PubMed id 12943630)9 Brennan P.A....Umar T. (Eur J Surg Oncol 2003)
    1110. Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. (PubMed id 12847270)9 Chen C.W....Lin W.W. (J. Immunol. 2003)
    1111. Impaired tubulointerstitial expression of endothelin-1 and nitric oxide isoforms in donor kidney biopsies with postischemic acute renal failure. (PubMed id 12973116)9 Mitterbauer C....Oberbauer R. (Transplantation 2003)
    1112. Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. (PubMed id 14638548)9 Dayoub H....Cooke J.P. (Circulation 2003)
    1113. Interactions between the nitric oxide and prostaglandin E2 biosynthetic pathways in human amnion-like WISH cells. (PubMed id 14568676)9 Biondi C....Vesce F. (J. Reprod. Immunol. 2003)
    1114. Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. (PubMed id 12517740)9 Weber S.M....Corbett J.A. (Am. J. Physiol. Endocrinol. Metab. 2003)
    1115. Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats. (PubMed id 12826065)9 Yonekura Y....Utsumi H. (Nitric Oxide 2003)
    1116. Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis. (PubMed id 12810424)9 Yki-JAorvinen H....Leirisalo-Repo M. (Ann. Rheum. Dis. 2003)
    1117. [Expression changes of nitric oxide synthase mRNA of hypothalamus after sleep deprivation in rats]. (PubMed id 12934610)9 Liu C.Y....Ruan F.M. (amp 2003)
    1118. Protein kinase C-eta (PKC-eta) is required for the development of inducible nitric oxide synthase (iNOS) positive phenotype in human monocytic cells. (PubMed id 14732335)9 Pham T.N....Richardson V.J. (Nitric Oxide 2003)
    1119. Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line. (PubMed id 12628472)9 Kamimura Y....Kawashima K. (Life Sci. 2003)
    1120. Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression. (PubMed id 12574380)9 Park D.W....Baek S.H. (J. Immunol. 2003)
    1121. Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice. (PubMed id 12794844)9 de Hooge A.S....van den Berg W.B. (Arthritis Rheum. 2003)
    1122. L-Arginine increases ischemic injury in wild-type mice but not in iNOS-deficient mice. (PubMed id 12618354)9 Zhao X....Iadecola C. (Brain Res. 2003)
    1123. Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages. (PubMed id 14719189)9 Pham T.N....Richardson V.J. (J. Rheumatol. 2003)
    1124. Is inducible nitric oxide synthase a target for chemoprevention? (PubMed id 12939472)9 Crowell J.A....Fay J.R. (Mol. Cancer Ther. 2003)
    1125. Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. (PubMed id 12839867)9 MAcrial-Kieny C....FAclActou M. (Br. J. Pharmacol. 2003)
    1126. Estrogen reduces angiotensin II-induced nitric oxide synthase and NAD(P)H oxidase expression in endothelial cells. (PubMed id 12524222)9 Gragasin F.S....Davidge S.T. (Arterioscler. Thromb. Vasc. Biol. 2003)
    1127. Oxidative stress in gastric mucosa of asymptomatic humans infected with Helicobacter pylori: effect of bacterial eradication. (PubMed id 12485120)9 Felley C.P....Felley-Bosco E. (Helicobacter 2002)
    1128. P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production. (PubMed id 12421638)9 Lahti A....Moilanen E. (Eur. J. Pharmacol. 2002)
    1129. Nitric oxide directly impairs intestinal barrier function. (PubMed id 11837790)9 Xu D.Z....Deitch E.A. (Shock 2002)
    1130. Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats. (PubMed id 12473873)9 Kobayashi N....Matsuoka H. (J. Hypertens. 2002)
    1131. Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression. (PubMed id 12363386)9 Xing G....Post R.M. (Schizophr. Res. 2002)
    1132. [The effects of hypoxia on the expression of inducible isoform of nitric oxide syntheses in nasal mucosal epithelial cells]. (PubMed id 12412420)9 Jiang S....Zhao L. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2002)
    1133. Effect of magnesium lithospermate B on calcium and nitric oxide in endothelial cells upon hypoxia/reoxygenation. (PubMed id 12370098)9 Luo W.B....Wang Y.P. (Acta Pharmacol. Sin. 2002)
    1134. Expression of inducible nitric oxide synthase during cisplatin-based chemotherapy for gastric cancer. (PubMed id 12182114)9 Ikeguchi M....Kaibara N. (In Vivo 2002)
    1135. Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck. (PubMed id 12404284)9 Franchi A....Gallo O. (Cancer 2002)
    1136. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. (PubMed id 12144868)9 Banerjee T....Ziboh V.A. (Prostaglandins Leukot. Essent. Fatty Acids 2002)
    1137. [Expression of inducible nitric oxide synthase and basic fibroblast growth factor in supraglottic squamous cell carcinoma and their clinical significance]. (PubMed id 12508542)9 Huang Z....Xia L.P. (Ai Zheng 2002)
    1138. Characterization of neurotransmitters and dopamine attenuation of inducible nitric oxide synthase in glioma cells. (PubMed id 12458038)9 Mazzio E....Soliman K.F. (J. Neuroimmunol. 2002)
    1139. The role of nitric oxide in ocular surface diseases. (PubMed id 12613978)9 Kim J.C....Yoon H.Y. (Adv. Exp. Med. Biol. 2002)
    1140. Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. (PubMed id 11754077)9 Cassina P....Barbeito L. (J. Neurosci. Res. 2002)
    1141. Expression of endothelial and inducible nitric oxide synthase in benign and malignant lesions of the breast and measurement of nitric oxide using electron paramagnetic resonance spectroscopy. (PubMed id 12216084)9 Loibl S....Kaufmann M. (Cancer 2002)
    1142. Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells. (PubMed id 12376366)9 Abraham N.G....Wolin M.S. (Am. J. Physiol. Lung Cell Mol. Physiol. 2002)
    1143. Evidence of oxidative stress in human corneal diseases. (PubMed id 11850437)9 Buddi R....Brown D.J. (J. Histochem. Cytochem. 2002)
    1144. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism. (PubMed id 11342476)9 Ferreiro C.R....Lemos Da Luz P. (Circulation 2001)
    1145. Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. (PubMed id 11730812)9 Dulak J....Dulakk J. (Atherosclerosis 2001)
    1146. Localization of 3-nitrotyrosine to rheumatoid and normal synovium. (PubMed id 11465704)9 Mapp P.I....Blake D.R. (Arthritis Rheum. 2001)
    1147. The time course of tumor necrosis factor-alpha, inducible nitric oxide synthase and vascular endothelial growth factor expression in an experimental model of chronic myocardial infarction in rats. (PubMed id 11399901)9 Heba G....DembiA8ska-KieA8 A. (J. Vasc. Res. 2001)
    1148. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. (PubMed id 11472219)9 Hah J.M....Silverman R.B. (J. Med. Chem. 2001)
    1149. Mucinous differentiation in colonic adenocarcinoma is associated with a reduction in tumour-infiltrating lymphocytes. (PubMed id 11373104)9 Millar E.K....Lee C.S. (Eur J Surg Oncol 2001)
    1150. Inhibition of nitric oxide synthase abrogates lipopolysaccharides-induced up-regulation of L-arginine uptake in rat alveolar macrophages. (PubMed id 11375254)9 Hammermann R....RackAc K. (Br. J. Pharmacol. 2001)
    1151. Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia. (PubMed id 11605048)9 Hayashi H....Kagawa S. (Oncol. Rep. 2001)
    1152. Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase. (PubMed id 11595474)9 Szepes Z....Whittle B.J. (J. Physiol. Paris 2001)
    1153. 4-hydroxynonenal prevents NO production in vascular smooth muscle cells by inhibiting nuclear factor-kappaB-dependent transcriptional activation of inducible NO synthase. (PubMed id 11451748)9 Hattori Y....Kasai K. (Arterioscler. Thromb. Vasc. Biol. 2001)
    1154. [Expression of the inducible isoform of nitric oxide synthase mRNA and the role in nasal polyps]. (PubMed id 12762002)9 Jiang S....Yang Z. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2001)
    1155. iNOS expression by activated neutrophils from patients with sepsis. (PubMed id 11167591)9 Tsukahara Y....Tanaka M. (ANZ J Surg 2001)
    1156. Nitric oxide synthase inhibition as therapy for sepsis: a decade of promise. (PubMed id 12594864)9 Cobb J.P. (Surg Infect (Larchmt) 2001)
    1157. Mechanisms of synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells. (PubMed id 11730360)9 Kwon S....George S.C. (Nitric Oxide 2001)
    1158. [Relationship between expression of inducible nitric oxide synthase and of VEGF in oral carcinoma]. (PubMed id 11930727)9 Zhao S....Ping F. (Zhonghua Kou Qiang Yi Xue Za Zhi 2001)
    1159. Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats. (PubMed id 11255630)9 Niwa M....Yoshida J. (Neurol. Med. Chir. (Tokyo) 2001)
    1160. Increased expression of eNOS protein in omental versus subcutaneous adipose tissue in obese human subjects. (PubMed id 11439294)9 RydAcn M....Andersson K. (Int. J. Obes. Relat. Metab. Disord. 2001)
    1161. Inducible nitric oxide synthase expression is increased in the brain in fatal cerebral malaria. (PubMed id 10971704)9 Maneerat Y....Udomsangpetch R. (Histopathology 2000)
    1162. GnRH agonist-suppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis. (PubMed id 11098019)9 Kamada Y....Kudo T. (Hum. Reprod. 2000)
    1163. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages. (PubMed id 11077049)9 Pan M.H....Lin J.K. (Biochem. Pharmacol. 2000)
    1164. Oxygen regulation of rat hepatocyte iNOS gene expression. (PubMed id 10782904)9 Vargiu C....Colombatto S. (J. Hepatol. 2000)
    1165. Differential and constitutive expression of neuronal, inducible, and endothelial nitric oxide synthase mRNAs and proteins in pathologically normal human tissues. (PubMed id 11020335)9 Park C.S....Cha Y.N. (Nitric Oxide 2000)
    1166. Antagonism of LPS and IFN-gamma induced iNOS expression in human atrial endothelia by morphine, anandamide, and estrogen. (PubMed id 11324436)9 Fimiani C....Stefano G.B. (Acta Pharmacol. Sin. 2000)
    1167. Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates. (PubMed id 10860828)9 Ryu Y.S....Hur G.M. (Biochem. Biophys. Res. Commun. 2000)
    1168. Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis. (PubMed id 11465019)9 Phul R.K....Smith M.E. (Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2000)
    1169. The role of nitric oxide in neoplastic transformation of C3H 10T1/2 embryonic fibroblasts. (PubMed id 11062159)9 Burnett T....Cooney R.V. (Carcinogenesis 2000)
    1170. Coronary vasomotor dysfunction in the cardiac allograft: impact of different immunosuppressive regimens. (PubMed id 11117379)9 Weis M....von Scheidt W. (J. Cardiovasc. Pharmacol. 2000)
    1171. Normal circulating adult human red blood cells contain inactive NOS proteins. (PubMed id 10850643)9 Kang E.S....Acchiardo S.R. (J. Lab. Clin. Med. 2000)
    1172. Regulation of nitric oxide production by arginine metabolic enzymes. (PubMed id 10973788)9 Mori M. and Gotoh T. (Biochem. Biophys. Res. Commun. 2000)
    1173. Constitutive and inducible nitric oxide synthases after dynorphin-induced spinal cord injury. (PubMed id 10697245)9 Hu W.H....Jen M.F. (J. Chem. Neuroanat. 2000)
    1174. Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases. (PubMed id 10428379)9 Lee Y....Silverman R.B. (amp 1999)
    1175. Membrane stabilization in harvested vein graft storage: effects on adhesion molecule expression and nitric oxide synthesis. (PubMed id 10485412)9 Vural K.M....Pinsky D.J. (Eur J Cardiothorac Surg 1999)
    1176. Human recombinant erythropoietin inhibits interleukin-1beta-stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells. (PubMed id 10193805)9 Kusano E....Asano Y. (Nephrol. Dial. Transplant. 1999)
    1177. HIV-1 infection induces differentiation of immature neural cells through autocrine tumor necrosis factor and nitric oxide production. (PubMed id 10497105)9 ObregA^n E....MuA+oz-FernA!ndez M.A. (Virology 1999)
    1178. Nitric oxide synthase activity in human squamous cell carcinoma of the head and neck. (PubMed id 9917057)9 Gavilanes J....Alvarez-Vicent J.J. (Laryngoscope 1999)
    1179. Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase. (PubMed id 10352298)9 DA-az-Guerra M.J....BoscA! L. (J. Immunol. 1999)
    1180. Caspase-activation and induction of inducible nitric oxide-synthase during TNF alpha-triggered apoptosis. (PubMed id 10470105)9 Binder C....Oellerich M. (Anticancer Res. 1999)
    1181. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. (PubMed id 10067972)9 Tilton R.G....Williamson J.R. (amp 1999)
    1182. N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase. (PubMed id 10447959)9 Huang H....Silverman R.B. (J. Med. Chem. 1999)
    1183. Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. (PubMed id 10383909)9 Ahn B....Ohshima H. (Carcinogenesis 1999)
    1184. The 42-amino acid insert in the FMN domain of neuronal nitric-oxide synthase exerts control over Ca(2+)/calmodulin-dependent electron transfer. (PubMed id 10521442)9 Daff S....Shimizu T. (J. Biol. Chem. 1999)
    1185. Inducible nitric oxide synthase activity by interferon-gamma-producing cells in human radicular cysts. (PubMed id 10371908)9 Takeichi O....Saito T. (Int Endod J 1999)
    1186. Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing. (PubMed id 10407101)9 Blum-Degen D....Gerlach M. (Brain Res. 1999)
    1187. The role of nitric oxide in L-arginine-stimulated growth hormone release. (PubMed id 10442577)9 Fisker S....rgensen J.O. (J. Endocrinol. Invest. 1999)
    1188. Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients. (PubMed id 10199221)9 Vincent V.A....Van Dam A.M. (AIDS 1999)
    1189. Inhibition of nuclear factor kappa B attenuates proinflammatory cytokine and inducible nitric-oxide synthase expression in postischemic myocardium. (PubMed id 9545547)9 Chandrasekar B....Freeman G.L. (Biochim. Biophys. Acta 1998)
    1190. Heme oxygenase and nitric oxide synthase in the placenta of the guinea-pig during gestation. (PubMed id 9778124)9 Odrcich M.J....Brien J.F. (Placenta 1998)
    1191. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. (PubMed id 9554441)9 Gallo O....Ziche M. (J. Natl. Cancer Inst. 1998)
    1192. Structural requirements for human inducible nitric oxide synthase substrates and substrate analogue inhibitors. (PubMed id 9521739)9 Grant S.K....Kozarich J.W. (Biochemistry 1998)
    1193. Expression of inducible nitric oxide synthase and inflammatory cytokines in alveolar macrophages of ARDS following sepsis. (PubMed id 9631804)9 Kobayashi A....Ashihara T. (Chest 1998)
    1194. Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo. (PubMed id 9740187)9 Shears L.L....Tzeng E. (J. Am. Coll. Surg. 1998)
    1195. Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes: implications for the model of cutaneous wound repair. (PubMed id 9856818)9 Frank S....Pfeilschifter J. (J. Invest. Dermatol. 1998)
    1196. HMN-1180, a small molecule inhibitor of neuronal nitric oxide synthase. (PubMed id 9864293)9 Nishio M....Hidaka H. (J. Pharmacol. Exp. Ther. 1998)
    1197. Placental nitric oxide production and umbilical artery vascular impedance in early pregnancy. (PubMed id 9572226)9 Lees C....Campbell S. (Obstet Gynecol 1998)
    1198. Complete coding sequence of inducible nitric oxide synthase from human heart and skeletal muscle of patients with chronic heart failure. (PubMed id 9851365)9 Adams V....Hambrecht R. (Nitric Oxide 1998)
    1199. Enhanced expression of inducible nitric oxide synthase in chronic gastritis with intestinal metaplasia. (PubMed id 9802453)9 Tatemichi M....Esumi H. (J. Clin. Gastroenterol. 1998)
    1200. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. (PubMed id 9765278)9 Geng Y....Lotz M. (J. Biol. Chem. 1998)
    1201. Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. (PubMed id 9237172)9 DueA+as-Gonzalez A....Rodriguez-Commes J. (Mod. Pathol. 1997)
    1202. Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters. (PubMed id 9288162)9 Silverman R.B....Martasek P. (J. Med. Chem. 1997)
    1203. Aseptic loosening of total hip replacement. Macrophage expression of inducible nitric oxide synthase and cyclo-oxygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure. (PubMed id 9180331)9 Hukkanen M....Polak J.M. (J Bone Joint Surg Br 1997)
    1204. Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria. (PubMed id 9392005)9 BAccherel P.A....Arock M. (Mol. Med. 1997)
    1205. NO synthase isozymes have distinct substrate binding sites. (PubMed id 9376373)9 Fan B....Rousseau D.L. (Biochemistry 1997)
    1206. Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. (PubMed id 9122229)9 Hooper D.C....Koprowski H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    1207. Activated astrocytes induce nitric oxide synthase-2 in cerebral endothelium via tumor necrosis factor alpha. (PubMed id 9419012)9 Shafer R.A. and Murphy S. (Glia 1997)
    1208. Effect of nitric oxide synthase inhibition on renal hemodynamics in humans: reversal by L-arginine. (PubMed id 9124393)9 Wolzt M....Krejcy K. (Am. J. Physiol. 1997)
    1209. Differential induction of constitutive and inducible nitric oxide synthases by distinct inflammatory stimuli in bovine aortic endothelial cells. (PubMed id 9099990)9 Kaku Y....Ikeda M. (Biochim. Biophys. Acta 1997)
    1210. Renal and systemic nitric oxide synthesis in rats with renal mass reduction. (PubMed id 9211360)9 Aiello S....Remuzzi G. (Kidney Int. 1997)
    1211. Effect of cyclic GMP-dependent vasodilators on the expression of inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. (PubMed id 8904645)9 Boese M....Schini-Kerth V. (Br. J. Pharmacol. 1996)
    1212. Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kappa B and interferon regulatory factor 1. (PubMed id 8864559)9 Hecker M....Busse R. (Br. J. Pharmacol. 1996)
    1213. Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase. (PubMed id 8639550)9 Sennequier N. and Stuehr D.J. (Biochemistry 1996)
    1214. Differential activity of nitric oxide synthase in human nasal mucosa and polyps. (PubMed id 8777951)9 Ramis I....Bulbena O. (Eur. Respir. J. 1996)
    1215. Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometry. (PubMed id 8672462)9 Salerno J.C....Masters B.S. (Biochemistry 1996)
    1216. Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets. (PubMed id 8656650)9 Chen L.Y. and Mehta J.L. (J. Cardiovasc. Pharmacol. 1996)
    1217. Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. (PubMed id 8875487)9 Hino A....Macdonald R.L. (Neurosurgery 1996)
    1218. Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. (PubMed id 8770041)9 Rockey D.C. and Chung J.J. (Am. J. Physiol. 1996)
    1219. Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells. (PubMed id 8662883)9 Saura M....Lamas S. (J. Biol. Chem. 1996)
    1220. Transcriptional basis for hyporesponsiveness of the human inducible nitric oxide synthase gene to lipopolysaccharide/interferon-gamma. (PubMed id 8613707)9 Zhang X....Murphy W.J. (J. Leukoc. Biol. 1996)
    1221. Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system. (PubMed id 8608001)9 Ingi T....Ronnett G.V. (Neuron 1996)
    1222. Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. (PubMed id 8938184)9 Morales-Ruiz M....Arroyo V. (Hepatology 1996)
    1223. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. (PubMed id 7535818)9 Blanco F.J....Lotz M. (J. Immunol. 1995)
    1224. Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. (PubMed id 7536934)9 Wu C.C....Vane J.R. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    1225. Human placental and fetal membrane nitric oxide synthase activity before, during and after labour at term. (PubMed id 8743155)9 Di Iulio J.L....Brennecke S.P. (Reprod. Fertil. Dev. 1995)
    1226. N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases. (PubMed id 7540822)9 Reif D.W. and McCreedy S.A. (Arch. Biochem. Biophys. 1995)
    1227. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. (PubMed id 7500055)9 Amin A.R....Abramson S.B. (J. Exp. Med. 1995)
    1228. Vesnarinone inhibits induction of nitric oxide synthase in J774 macrophages and rat cardiac myocytes in culture. (PubMed id 7585804)9 Hattori Y....Shimoda S. (Cardiovasc. Res. 1995)
    1229. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. (PubMed id 7530002)9 Brouet I. and Ohshima H. (Biochem. Biophys. Res. Commun. 1995)
    1230. Cycloheximide induces nitric oxide synthase mRNA in vascular smooth muscle cells by prolonging mRNA lifetime. (PubMed id 8595383)9 Hattori Y. and Gross S.S. (Biochem. Mol. Biol. Int. 1995)
    1231. Regulation of human placental fetal vessel tone: role of nitric oxide. (PubMed id 8743139)9 King R.G....Brennecke S.P. (Reprod. Fertil. Dev. 1995)
    1232. Dexamethasone differentially affects interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase mRNA expression in renal mesangial cells. (PubMed id 7528007)9 Kunz D....Pfeilschifter J. (Biochem. J. 1994)
    1233. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. (PubMed id 7523409)9 Garvey E.P....Furfine E.S. (J. Biol. Chem. 1994)
    1234. Towards achieving the Health of the Nation target for cervical cancer: accuracy of cancer registration. (PubMed id 8037953)9 Lancaster G....Woodman C. (J Public Health Med 1994)
    1235. Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years. (PubMed id 1332483)9 Domagala W....Osborn M. (Am. J. Pathol. 1992)
    1236. Vimentin expression appears to be associated with poor prognosis in node-negative ductal NOS breast carcinomas. (PubMed id 1701960)9 Domagala W....Osborn M. (Am. J. Pathol. 1990)
    1237. (PubMed id 20148433)9 
    1238. Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production. (PubMed id 19932078)9 Sun J....Zweier J.L. (Arch. Biochem. Biophys. 2010)
    1239. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. (PubMed id 20482831)9 Wilms H....Lucius R. (J Neuroinflammation 2010)
    1240. Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy. (PubMed id 20215556)9 Sikora A.G....Overwijk W.W. (Clin. Cancer Res. 2010)
    1241. Proangiogenetic molecules, hypoxia-inducible factor-1alpha and nitric oxide synthase isoforms in ovarian endometriotic cysts. (PubMed id 20473769)9 Goteri G....Ciavattini A. (Virchows Arch. 2010)
    1242. Inhibition of L-arginine metabolizing enzymes by L-arginine-derived advanced glycation end products. (PubMed id 20216951)9 Lai Y.L....Ohshima H. (J Clin Biochem Nutr 2010)
    1243. Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. (PubMed id 20470258)9 Pi S.H....Kim E.C. (J. Periodont. Res. 2010)
    1244. Neurodegeneration and increased production of nitrotyrosine, nitric oxide synthase, IFN-gamma and S100beta protein in the spinal cord of IL-12p40-deficient mice infected with Trypanosoma cruzi. (PubMed id 19923851)9 Bombeiro A.L....Alvarez J.M. (Neuroimmunomodulation 2010)
    1245. Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. (PubMed id 20421938)9 Yeo T.W....Anstey N.M. (PLoS Pathog. 2010)
    1246. Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage. (PubMed id 20074562)9 Takeuchi K....Satoh H. ( international journal of clinical chemistry 2010)
    1247. Exposure to polychlorinated biphenyls enhances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: a potential role for myeloperoxidase. (PubMed id 20067832)9 Saed G.M....Abu-Soud H.M. (amp 2010)
    1248. A subcutaneous mandibulotomy approach for a salivary clear cell carcinoma of the retromolar trigone. (PubMed id 18696176)9 Fennessy B.G....Timon C. (Ir J Med Sci 2010)
    1249. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. (PubMed id 20004202)9 Thurston R.D....Ghishan F.K. (Gastroenterology 2010)
    1250. Production and scavenging of nitric oxide by barley root mitochondria. (PubMed id 20185408)9 Gupta K.J. and Kaiser W.M. (amp 2010)
    1251. The protective effects of Polygonum multiflorum stilbeneglycoside preconditioning in an ischemia/reperfusion model of HUVECs. (PubMed id 20228828)9 Liu L.P....He M. (Acta Pharmacol. Sin. 2010)
    1252. Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. (PubMed id 19673871)9 Tsutakawa S....Nakahata N. (Br. J. Dermatol. 2009)
    1253. Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma. (PubMed id 18830569)9 Campos A.H....Soares F.A. (Mol. Cell. Biochem. 2009)
    1254. Induction of endostatin expression in meniscal fibrochondrocytes by co-culture with endothelial cells. (PubMed id 18839188)9 Hoberg M....Rudert M. (Arch Orthop Trauma Surg 2009)
    1255. Galactosyl derivative of N(omega)-nitro-L-arginine: study of antiproliferative activity on human thyroid follicular carcinoma cells. (PubMed id 19650107)9 Melisi D....Rimoli M.G. (J. Cell. Physiol. 2009)
    1256. Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene. (PubMed id 19554613)9 Li F. and Mahato R.I. (J Gene Med 2009)
    1257. Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach. (PubMed id 19685003)9 Matsumoto Y....Chayama K. (J. Gastroenterol. 2009)
    1258. Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. (PubMed id 19663884)9 Jean Y.H....Wen Z.H. (Br. J. Pharmacol. 2009)
    1259. Mycobacterium bovis with different genotypes and from different hosts induce dissimilar immunopathological lesions in a mouse model of tuberculosis. (PubMed id 19659779)9 Aguilar LeA^n D....HernA!ndez Pando R. (Clin. Exp. Immunol. 2009)
    1260. Chronic endurance exercise induces quadriceps nitrosative stress in patients with severe COPD. (PubMed id 18835959)9 Barreiro E....Roca J. (Thorax 2009)
    1261. Bis-(3-hydroxyphenyl) diselenide inhibits LPS-stimulated iNOS and COX-2 expression in RAW 264.7 macrophage cells through the NF-kappaB inactivation. (PubMed id 19298695)9 Shin K.M....Lee K.T. (J. Pharm. Pharmacol. 2009)
    1262. A benzoxazine derivative induces vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 by elevating NADPH oxidase activity and reactive oxygen species levels. (PubMed id 19539746)9 Zhao J....Miao J. (Toxicol In Vitro 2009)
    1263. Rosuvastatin protects against angiotensin II-induced renal injury in a dose-dependent fashion. (PubMed id 19262227)9 Park J.K....Haller H. (J. Hypertens. 2009)
    1264. Anti-inflammatory properties of the plant Verbascum mallophorum. (PubMed id 19828096)9 Speranza L....Grilli A. (J. Biol. Regul. Homeost. Agents 2009)
    1265. [The protective effect of nourishing yin and promoting blood flow recipe on the aortic endothelium injury of diabetic rats]. (PubMed id 19960948)9 Li B....Cao D. (Zhong Yao Cai 2009)
    1266. Alternatively activated and immunoregulatory monocytes in human filarial infections. (PubMed id 19456233)9 Babu S....Nutman T.B. (J. Infect. Dis. 2009)
    1267. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. (PubMed id 19374401)9 Bonnefous C....Smith N.D. (J. Med. Chem. 2009)
    1268. Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. (PubMed id 19298861)9 Zhou L. and Zhu D.Y. (Nitric Oxide 2009)
    1269. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors. (PubMed id 19117642)9 LA^pez Cara L.C....Entrena A. (Eur J Med Chem 2009)
    1270. Beta-carotene prevents ozone-induced proinflammatory markers in murine skin. (PubMed id 19651793)9 Valacchi G....Davis P.A. (Toxicol Ind Health 2009)
    1271. Curcumin prevents shock-wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats. (PubMed id 19340419)9 Bas M....Tasci A.I. (Urol. Res. 2009)
    1272. Protective effects of kaempferol against endothelial damage by an improvement in nitric oxide production and a decrease in asymmetric dimethylarginine level. (PubMed id 19549512)9 Xiao H.B....Sun Z.L. (Eur. J. Pharmacol. 2009)
    1273. Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury. (PubMed id 19038279)9 Jung M....Sola A. (Toxicol. Appl. Pharmacol. 2009)
    1274. Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function. (PubMed id 19494147)9 Page A.J....Blackshaw L.A. (J. Neurosci. 2009)
    1275. Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells. (PubMed id 19478557)9 Lee J.A....Park J.S. (amp 2009)
    1276. Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. (PubMed id 18719059)9 Brindicci C....Kharitonov S.A. (Chest 2009)
    1277. Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. (PubMed id 19344390)9 Kato G.J....Hazen S.L. (Br. J. Haematol. 2009)
    1278. Association between color doppler vascularity index, angiogenesis-related molecules, and clinical outcomes in gastric cancer. (PubMed id 19418489)9 Chen C.N....Lee P.H. (J Surg Oncol 2009)
    1279. Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. (PubMed id 19617644)9 Konturek P.C....Konturek S.J. (J. Physiol. Pharmacol. 2009)
    1280. Hypercholesterolaemia induces early renal lesions characterized by upregulation of MMP-9 and iNOS and ET(A)R: alleviated by a dual endothelin receptor antagonist CPU0213 and simvastatin. (PubMed id 19505368)9 Luo L....Dai D.Z. (J. Pharm. Pharmacol. 2009)