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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOS1AP Gene

protein-coding   GIFtS: 56
GCID: GC01P162039

Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein1 2     C-Terminal PDZ Domain Ligand Of Neuronal Nitric Oxide Synthase1
CAPON2 3 5     6330408P19Rik2
Nitric Oxide Synthase 1 Adaptor Protein2 3     C-Terminal PDZ Domain Ligand Of Neuronal Nitric Oxide Synthase (CAPON)2
C-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein2 3     Carboxyl-Terminal PDZ Ligand Of Neuronal Nitric Oxide Synthase Protein2
KIAA04643 5     Ligand Of Neuronal Nitric Oxide Synthase With Carboxyl-Terminal PDZ Domain2

External Ids:    HGNC: 168591   Entrez Gene: 97222   Ensembl: ENSG000001989297   OMIM: 6055515   UniProtKB: O750523   

Export aliases for NOS1AP gene to outside databases

Previous GC identifers: GC01P158772 GC01P160306 GC01P133284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOS1AP Gene:
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS).
This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal
phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related
mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific
targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Sep 2009)

GeneCards Summary for NOS1AP Gene: 
NOS1AP (nitric oxide synthase 1 (neuronal) adaptor protein) is a protein-coding gene. Diseases associated with NOS1AP include neuronitis, and long qt syndrome, and among its related super-pathways are Retrograde endocannabinoid signaling. GO annotations related to this gene include PDZ domain binding and nitric-oxide synthase binding. An important paralog of this gene is ENSG00000254706.

UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052
Function: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with
nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a
presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1
to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating
the interaction between NOS1 and DLG4 (By similarity)

Gene Wiki entry for NOS1AP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOS1AP gene promoter:
         Nkx3-1   Nkx3-1 v4   Lmo2   NF-AT   GATA-2   PPAR-alpha   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOS1AP promoter sequence
   Search SABiosciences Chromatin IP Primers for NOS1AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOS1AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

NOS1AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOS1AP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162039:  view genomic region     (about GC identifiers)

Start:
162,039,564 bp from pter      End:
162,353,321 bp from pter
Size:
313,758 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 (See protein sequence)
Recommended Name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein  
Size: 506 amino acids; 56150 Da
Subunit: Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts
with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and RASD1. Forms a
ternary complex with NOS1 and SYN1 (By similarity)
Sequence caution: Sequence=BAA32309.2; Type=Erroneous initiation;
Secondary accessions: B7ZLF5 O43564 Q3T551 Q5VU95
Alternative splicing: 3 isoforms:  O75052-1   O75052-2   O75052-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOS1AP: NX_O75052

Explore proteomics data for NOS1AP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75052

  • NOS1AP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOS1AP Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001119532.2  NP_001158229.1  NP_055512.1  

    ENSEMBL proteins: 
     ENSP00000431586   ENSP00000355133   ENSP00000396713   ENSP00000435711   ENSP00000434988  
     ENSP00000356909  

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    Cloud-Clone Corp. Proteins for NOS1AP 


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    Cloud-Clone Corp. CLIAs for NOS1AP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR006020 PTyr_interaction_dom

    Graphical View of Domain Structure for InterPro Entry O75052

    ProtoNet protein and cluster: O75052

    UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052
    Similarity: Contains 1 PID domain


    NOS1AP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAPON_HUMAN, O75052
    Function: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with
    nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a
    presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1
    to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating
    the interaction between NOS1 and DLG4 (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030165PDZ domain binding ISS9459447
    GO:0050998nitric-oxide synthase binding ISS9459447
         
    NOS1AP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOS1AP 
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate NOS1AP (see all 33):
    hsa-miR-219-1-3p hsa-miR-449a hsa-miR-330-3p hsa-miR-374b* hsa-miR-4324 hsa-miR-548am hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidNOS1AP 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS1AP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOS1AP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Circadian entrainment0.40
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NOS1AP
        SIDS Susceptibility Pathways



    1         Kegg Pathway  (Kegg details for NOS1AP):
        Circadian entrainment


    NOS1AP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOS1AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/16 Interacting proteins for NOS1AP (O750523 ENSP000003551334) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYN3O149943, ENSP000003516144I2D: score=3 STRING: ENSP00000351614
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    LRP2P981643, ENSP000002638164I2D: score=2 STRING: ENSP00000263816
    NOS1P294753, ENSP000003207584I2D: score=2 STRING: ENSP00000320758
    PTPRNQ168493, ENSP000002957184I2D: score=2 STRING: ENSP00000295718
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042981regulation of apoptotic process NAS--
    GO:0045428regulation of nitric oxide biosynthetic process NAS--
    GO:0050999regulation of nitric-oxide synthase activity NAS--

    NOS1AP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOS1AP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOS1AP (CAPON)

    2 Novoseek inferred chemical compound relationships for NOS1AP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 53.6 19 18337493 (2), 19204306 (2), 15561099 (1), 18235038 (1) (see all 9)
    nmda 19 3 9459447 (1), 16146415 (1)

    2 PharmGKB related drug/compound annotations for NOS1AP gene    About this table
    Drug/compound PharmGKB Annotation
    amiodaroneCA  
    verapamilCA  

    Search CenterWatch for drugs/clinical trials and news about NOS1AP / CAPON

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOS1AP gene (3 alternative transcripts): 
    NM_001126060.1  NM_001164757.1  NM_014697.2  

    Unigene Cluster for NOS1AP:

    Nitric oxide synthase 1 (neuronal) adaptor protein
    Hs.731942  [show with all ESTs]
    Unigene Representative Sequence: AY841899
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530878(uc010pkr.1) ENST00000361897(uc001gbv.2 uc001gbw.2 uc010pks.1)
    ENST00000430120 ENST00000464284 ENST00000493151(uc009wut.1) ENST00000454693
    ENST00000367932
    miRNA
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    hsa-miR-219-1-3p hsa-miR-449a hsa-miR-330-3p hsa-miR-374b* hsa-miR-4324 hsa-miR-548am hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidNOS1AP 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS1AP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS1AP
    Sirion Biotech Customized lentivirus for stable overexpression of NOS1AP 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOS1AP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOS1AP

    Additional mRNA sequence: 

    AB007933.2 AF037070.1 AK024942.1 AY841899.1 BC041382.2 BC112295.1 BC143771.1 BC143780.1 

    5 DOTS entries:

    DT.101013  DT.431228  DT.95260314  DT.91928393  DT.97822347 

    24/58 AceView cDNA sequences (see all 58):

    AF037070 AI915161 AB007933 AI150129 NM_014697 BX952349 AA478926 AW339403 
    BG819229 BX281100 AW136439 BM999232 AA928879 BF342968 AI802226 AK023199 
    AU131738 AI559183 AI198232 AU125189 AI937609 AI480219 BC041382 AI683194 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOS1AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTTTCTT
    NOS1AP Expression
    About this image


    See NOS1AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOS1AP

    SOURCE GeneReport for Unigene cluster: Hs.731942
        SABiosciences Expression via Pathway-Focused PCR Arrays including NOS1AP: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS1AP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NOS1AP gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nos1ap1 , 5 nitric oxide synthase 1 (neuronal) adaptor protein1, 5 90.22(n)1
    96.01(a)1
      1 (76.84 cM)5
    707291  NM_001109985.11  NP_001103455.11 
     1703026685 
    chicken
    (Gallus gallus)
    Aves NOS1AP1 nitric oxide synthase 1 (neuronal) adaptor protein 80.18(n)
    82.48(a)
      424371  XM_422215.3  XP_422215.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    42(a)
    1 → many
    GL343405.1(27123-88040)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.305042 Xenopus laevis transcribed sequence with weak similarity more 80.21(n)    BG364067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nos1apa1 nitric oxide synthase 1 (neuronal) adaptor protein more 70.99(n)
    75.66(a)
      553539  XM_002662480.2  XP_002662526.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG426736
    --
    11(a)
    possible ortholog
    3L(9540320-9589813)
    worm
    (Caenorhabditis elegans)
    Secernentea dyc-16
    Dystrophin-like protein 1
    21(a)
    possible ortholog
    X(14049535-14063875)


    ENSEMBL Gene Tree for NOS1AP (if available)
    TreeFam Gene Tree for NOS1AP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOS1AP gene
    ENSG000002547062  

    NOS1AP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052
    Polymorphism: Genetic variation in NOS1AP influences the electrocardiographic QT interval [MIM:610141]. The QT
    interval is defined as the time from the beginning of the Q wave to the end of the T wave, representing the
    duration of ventricular electrical activity. The QT interval, a measure of cardiac repolarization, is a
    genetically influenced quantitative trait with considerable medical relevance: both high and low values are
    associated with increased risk of cardiovascular morbidity and mortality


    10/6185 SNPs in NOS1AP are shown (see all 6185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774736231,2
    C,Fprobable-non-pathogenic1168876711(+) CTGTCC/TACTCA 4 S syn13Minor allele frequency- T:0.01NA EU 5925
    rs343985051,2
    C,Funknown1168886794(+) GGGCGC/TGGGCT 6 A V mis12Minor allele frequency- T:0.01NA 4516
    rs357569451,2
    C--133296464(+) ATTTG-/TTTTTT 2 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs22258471,2
    C,F,A,H--133321894(+) ATAAAG/ATTAGG 2 -- int111Minor allele frequency- A:0.39NA WA CSA EA 376
    rs3724762991,2
    C--133334996(+) AGGAT-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs741259111,2
    C,F--133342863(+) AAAAAG/ATCTGT 2 -- int13Minor allele frequency- A:0.50WA CSA 6
    rs2019899501,2
    --133404457(+) TTTAA-/ATTTTAT 2 -- int10--------
    rs112932451,2
    C,F--133417260(+) GGCTGT/-TTTTT 2 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs105517991,2
    C--133428363(+) GTTCG-/TTCA  
            
    TTCAT
    2 -- int11Minor allele frequency- TTCA:0.50CSA 2
    rs342692211,2
    C--133441020(+) TTTTT-/TAAATC 2 -- int10--------

    HapMap Linkage Disequilibrium report for NOS1AP (162039564 - 162289564 bp, first 250kb of NOS1AP)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for NOS1AP (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3877CNV Deletion18987735
    esv988854CNV Deletion20482838
    esv2653197CNV Deletion19546169
    esv2662394CNV Deletion23128226
    esv2718906CNV Deletion23290073
    esv1282003CNV Deletion17803354
    esv2718918CNV Deletion23290073
    esv2667219CNV Deletion23128226
    esv2951CNV Deletion18987735
    esv2055258CNV Deletion18987734


    Human Gene Mutation Database (HGMD): NOS1AP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605551    OMIM disorders: --

    10 diseases for NOS1AP:    About MalaCards
    neuronitis    long qt syndrome    schizophrenia    bipolar disorder
    insulin resistance    atherosclerosis    diabetes mellitus    obesity
    pancreatitis    breast cancer


    NOS1AP for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NOS1AP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    death sudden cardiac 60 2 19204306 (1)
    schizophrenia 40.4 25 19077434 (6), 16146415 (4), 15707951 (3), 18414510 (1)

    Genetic Association Database (GAD): NOS1AP
    Human Genome Epidemiology (HuGE) Navigator: NOS1AP (47 documents)

    Export disorders for NOS1AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOS1AP gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with NOS1AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. (PubMed id 9459447)1, 2, 3, 9 Jaffrey S.R.... Snyder S.H. (1998)
    2. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. (PubMed id 16648850)1, 2, 4 Arking D.E.... Chakravarti A. (2006)
    3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
    4. Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. (PubMed id 16146415)1, 2, 9 Xu B....Brzustowicz L.M. (2005)
    5. Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate. (PubMed id 19077434)1, 4, 9 Kremeyer B....Ruiz-Linares A. (2009)
    6. Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. (PubMed id 19204306)1, 4, 9 Kao W.H....Chakravarti A. (2009)
    7. Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish. (PubMed id 17565224)1, 4, 9 Post W....Shuldiner A.R. (2007)
    8. NOS1AP variant associated with incidence of type 2 di abetes in calcium channel blocker users in the Atherosclerosis Risk in Communit ies (ARIC) study. (PubMed id 19943157)1, 4, 9 Chu A.Y....Kao W.H. (2010)
    9. Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration. (PubMed id 18927126)1, 4, 9 Eijgelsheim M....Stricker B.H. (2009)
    10. Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. (PubMed id 18551039)1, 4, 9 Becker M.L....Stricker B.H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9722 HGNC: 16859 AceView: CAPON Ensembl:ENSG00000198929 euGenes: HUgn9722
    ECgene: NOS1AP Kegg: 9722 H-InvDB: NOS1AP

    (According to HUGE)
    About This Section
    HUGE: KIAA0464

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOS1AP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOS1AP gene:
    Search GeneIP for patents involving NOS1AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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